Academic literature on the topic 'Atmospheric Nitrogen Gas Plasma Sterilization'
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Journal articles on the topic "Atmospheric Nitrogen Gas Plasma Sterilization"
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Hideharu, Shintani, N. Shimizu, Y. Imanishi, A. Sakudo, U. Takuya, and E. Hotta. "Efficiency of Atmospheric Pressure Nitrogen Gas Remote Plasma Sterilization and the Clarification of Sterilization Major Factors." International Journal of Clinical Pharmacology & Toxicology (IJCPT) 4, no. 2 (2015): 150–60. https://doi.org/10.19070/2167-910X-1500027.
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Experiments reported here were conducted using atmospheric nitrogen gas remote plasma with a pulsed power source. The sterilization efficiency, major sterilization factors and most appropriate sterilization conditions were determined. By varying several factors such as hotplate temperature, relative humidity, water vapor supply location, etc., the most appropriate sterilization conditions were identified. The temperature of the hotplate was varied from 55°C to 75°C and with this 20°C increase in temperature, sterilization was completed in half the time. In this experiment, it was confirmed that the combined effect of a relative humidity (RH) of 0.5% and nitrogen gas was superior to the use of nitrogen gas alone. Furthermore, it was clarified that the optimal humidity was in the range of 0-5 % RH. When RHs of 0, 0.5 and 5% were tested, 0.5% RH was found to be optimal for sterilization. The location of the water vapor supply was changed relative to the hotplate, and use of the most remote port upstream of the reactor resulted in the most efficient sterilization. In addition, the results correlated with the amount of NO radicals generated. The NO radical is the precursor of OONO • - (peroxynitrite anion radical). The sterilization factors associated with this experiment were NO radicals, H2O2, OH radicals, O2• - (superoxide anion radicals) and OONO • -. Only OONO • - production correlated with sterilization efficiency. Therefore, OONO • - is thought to be the major factor for nitrogen gas plasma sterilization. In addition, as already described, the highest sterilization efficiency was with 0.5% RH and the amount of OONO • - produced correlated with the RH. These data support the idea that OONO • - is the major contributing factor for nitrogen gas plasma sterilization. The D values for this experiment were approximately 10 min.
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Sharma, Vinita, Katsuhiko Hosoi, Tamio Mori, and Shin-ichi Kuroda. "Electrical and Optical Characterization of Cold Atmospheric Pressure Plasma Jet and the Effects of N2 Gas on Argon Plasma Discharge." Applied Mechanics and Materials 268-270 (December 2012): 522–28. http://dx.doi.org/10.4028/www.scientific.net/amm.268-270.522.
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In this study, we conducted experiments to investigate the electrical and optical characteristics of a non-equilibrium Ar-N2 plasma discharge at atmospheric pressure. To obtain the plasma discharge we used our indigenously designed plasma generating device named CAPPLAT (Cold Atmospheric Pressure Plasma Torch) which was manufactured by Cresur Corporation. The plasma discharge obtained with only Ar gas was quite filamentary. So, to achieve a homogeneous discharge N2 gas was admixed. The effects of different volumes of admixed N2 gas were also studied. The optical emission spectroscopy was used to study the active charged species in the plasma discharges. The further increased volume of N2 gas further suppressed the emission intensity of Ar metastables but at the same time the emission intensity of the second positive system of nitrogen molecules (N2(C3Πu) enhanced significantly. It can be concluded that in Ar- plasma discharge, argon metastables are the main energy carriers but when N2 gas is added to the feeding gas (Ar) for plasma generation, the second positive system of nitrogen molecules (N2(C3Πu) become the main energy carriers. On the other hand the addition of the N2 gas doesn’t change the electrical characteristics of plasma discharge significantly. To identify the effectiveness of the CAPPLAT as a tool for sterilization, highly environmental stress resistant bacterial (Bacillus subtilis) endospores were treated for different durations. We could successfully deactivate the population of 1.0X107 to 4.0X107 Bacillus endospores/ml. The details of this experiment are discussed in our next paper.
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Zhang, Xinying, Runze Fan, Miao Qi, et al. "Studies on a sinusoidally driven gas–liquid two-phase plasma discharge and its application to sterilization." AIP Advances 12, no. 11 (2022): 115218. http://dx.doi.org/10.1063/5.0100815.
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Atmospheric pressure cold plasmas are widely used in the biomedical field as evidenced by developments in recent years. In this study, a quartz tube-guided gas–liquid two-phase discharge has been configured with a hollow needle-water structure. The power source for the device was sinusoidal, and switching between a gas–liquid miscible discharge and a pure gaseous discharge was simple. It was discovered that the gas–liquid discharge was beneficial in terms of reactant species generation and reaction efficiency in terms of processing water. The types of particles, the physicochemical properties, and the concentrations of reactive oxygen and nitrogen species in the discharge were studied spectroscopically. The discharge was discovered to have high levels of H2O2 and NO2−, and the activated water was proven to be effective at sterilizing samples that were contaminated with micro-organisms. Key experimental parameters including the driving voltage and the air flow rate were optimized to achieve the best sterilization conditions. The membrane potential changes in the treated bacteria were also studied to explore the causes of bacterial inactivation. The results showed that the device exhibited a strong bactericidal effect for the gas–liquid mixed phase discharge operating at 17 kV for 5 min with a gas flow rate of 0.3 SLM. In addition, the present device offers enhanced sterilization efficiency relative to the efficiency of conventional plasma sterilization equipment and, therefore, has a wide range of applications.
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Vasilets, Victor N. "PLASMACHEMICAL GENERATION OF NITRIC OXIDES IN AIR PLASMAS FOR MEDICAL APPLICATIONS." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 62, no. 5 (2019): 4–13. http://dx.doi.org/10.6060/ivkkt.20196205.5958.
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Nitric oxide is well known as a poly functional regulator of different physiological processes in human body and therefore could be used for therapeutic purposes in different medical applications. In this review mechanism of nitric oxide generation in gas plasma and biological mechanisms of nitric oxide containing plasma gas treatment of tissues are described. In addition to nitric oxide the other biologically active species like hydrogen peroxide and nitrogen dioxide are formed in air plasma at atmospheric pressure. Synergetic action of molecules NO/H2O2 и NO/O2, generated in plasma gas results to manifold increase of sterilization activity of plasma mixture to bacteria and at the same time the toxicity of these species to living cells is low. Plasma gas exhibits therapeutic action on human tissues. On the one hand plasma gas contains molecules Н2О2, NO and NO2 acting as a antimicrobial agents and promoting sterilization, on the other hand the presence of significant concentration of NO leads to effective regeneration of damaged tissue. These processes are complementary and finally result to effective healing of diabetic trophic ulcer and other diseases in the oncology, ophthalmology, dentistry, purulent surgery, battlefield surgery and so on. Peculiarities of different discharges which could be used for generation of nitric oxide, like arc discharge, gliding arc discharge, microwave discharge, radiofrequency and pulsed discharges are discussed. The production of nitric oxide depending on type of discharge and plasma parameters like discharge power, gas flow rate and electrode configuration are analyzed. The efficacy of nitric oxide generation in different discharges is compared.
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Akishev, Yuri, Michail Grushin, Vladimir Karalnik, et al. "Atmospheric-pressure, nonthermal plasma sterilization of microorganisms in liquids and on surfaces." Pure and Applied Chemistry 80, no. 9 (2008): 1953–69. http://dx.doi.org/10.1351/pac200880091953.
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Gas discharge plasma inactivation of microorganisms at low (close to ambient) temperature is a promising area of investigation that is attracting widespread interest. This paper describes atmospheric-pressure, nonthermal plasma (NTP) methods for cold sterilization of liquids and thermal sensitive surfaces. These methods are based on the use of direct current (DC) gas discharge plasma sources fed with steady-state high voltage. Parameters characterizing the plasma sources used (plasma-forming gas, gas flow rate, electric power consumed, etc.) are given. The results for plasma sterilization of different microorganisms (vegetative cells, spores, fungi, biofilms) are presented. An empirical mathematical approach is developed for describing NTP inactivation of microorganisms. This approach takes into account not only the destruction of different components of the cells, but their reparation as well.
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Hauser, Joerg, Stefan-Alexander Esenwein, Peter Awakowicz, Hans-Ulrich Steinau, Manfred Köller, and Helmut Halfmann. "Sterilization of Heat-Sensitive Silicone Implant Material by Low-Pressure Gas Plasma." Biomedical Instrumentation & Technology 45, no. 1 (2011): 75–79. http://dx.doi.org/10.2345/0899-8205-45.1.75.
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Abstract Background: In recent years, plasma treatment of medical devices and implant materials has gained more and more acceptance. Inactivation of microorganisms by exposure to ultraviolet (UV) radiation produced by plasma discharges and sterilization of medical implants and instruments is one possible application of this technique. The aim of this study was to evaluate the effectiveness of this sterilization technique on silicone implant material. Methods: Bacillus atrophaeus spores (106 colony-forming units [CFUs]) were sprayed on the surfaces of 12 silicone implant material samples. Four plasma sets with different gas mixtures (argon [Ar], argon–oxygen [Ar:O2], argon–hydrogen [Ar:H2] and argon–nitrogen [Ar:N2]) were tested for their antimicrobial properties. Post-sterilization mechanical testing of the implant material was performed in order to evaluate possible plasma-induced structural damage. Results: The inductively coupled low-pressure plasma technique can achieve fast and efficient sterilization of silicone implant material without adverse materials effects. All four gas mixtures led to a significant spore reduction, and no structural damage to the implant material could be observed.
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Feng, Fada, Xianjun He, Yingying Liang, et al. "Ar plasma jet generation and its application for water and surface sterilization." E3S Web of Conferences 78 (2019): 02020. http://dx.doi.org/10.1051/e3sconf/20197802020.
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Microorganisms are widely distributed in the living environment of human, animals and plants. Some of the microorganisms are harmful for their pathogenic effects. Non-thermal plasma technology, especially, the atmospheric pressure plasma jet, is considered to be one of the promising technologies for sterilization. This work proposes a double-dielectric barrier discharge reactor for Ar plasma jet generation. Charteristics of discharge and temperature thermogram of plasma jet are investigated by the means of U-P curve and infrared image, respectively. Performance of the plasma jet is evaluated by surface and water sterilization. The results show that, Ar plasma jet is generated stable with double-dielectric barrier discharge. The length of plasma jet increases as the applied voltage, frequency or gas flow increased, but the plasma jet generation can be restricted in high frequency or gas flow. For E. coli in the water and surface, high sterilization efficiency is observed for a short time treatment by Ar plasma jet.
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Sakudo, Akikazu, Risa Yamashiro, and Takashi Onodera. "Recent Advances in Prion Inactivation by Plasma Sterilizer." International Journal of Molecular Sciences 23, no. 18 (2022): 10241. http://dx.doi.org/10.3390/ijms231810241.
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Prions, which cause transmissible spongiform encephalopathies (TSEs), are a notorious group of infectious agents with possibly the highest resistance to complete inactivation. Although various gas plasma instruments have been developed, studies on prion inactivation using gas plasma instruments are limited. Among them, the hydrogen peroxide gas plasma instrument, STERRAD® (Advanced Sterilization Products; ASP, Johnson & Johnson, Irvine, CA, USA), is recommended for prion inactivation of heat-sensitive medical devices. However, STERRAD® is not a plasma sterilizer but a hydrogen peroxide gas sterilizer. In STERRAD®, plasma generated by radio frequency (RF) discharge removes excess hydrogen peroxide gas and does not contribute to sterilization. This is also supported by evidence that the instrument was not affected by the presence or absence of RF gas plasma. However, recent studies have shown that other gas plasma instruments derived from air, nitrogen, oxygen, Ar, and a mixture of gases using corona, dielectric barrier, microwave, and pulse discharges can inactivate scrapie prions. As inactivation studies on prions other than scrapie are limited, further accumulation of evidence on the effectiveness of gas plasma using human-derived prion samples is warranted for practical purposes.
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Raad, Alaa, and Hanaa Essa. "The Impact of Argon Flow Rates on Plasma Behavior in Plasma Jet Systems for Medical Applications." Journal for Research in Applied Sciences and Biotechnology 3, no. 1 (2024): 99–108. http://dx.doi.org/10.55544/jrasb.3.1.17.
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This research presents a thorough spectroscopic investigation of atmospheric- plasma generated by a plasma jet. The study examines the plasma behavior under varying flow rates of argon gas. A primary objective is to identify the optimal flow rate that facilitates the application of the generated plasma in sterilization and bacterial eradication operations. The findings establish a correlation between argon flow and critical plasma parameters, specifically noting variations in electron temperature (Te) & electron number density (ne). Crucially, the study demonstrates that lower argon flow rates are more effective in generating active species such as hydroxyl and NO reactive species. The results of this investigation hold significant promise for advancing our comprehension of plasma jet technology's utility in sterilization or medical treatment processes, emphasizing the importance of gas flow optimization for these applications.
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Xu, Dehui, Xinying Zhang, Jin Zhang, Rui Feng, Shuai Wang, and Yanjie Yang. "Metabolomics of Pseudomonas aeruginosa Treated by Atmospheric-Pressure Cold Plasma." Applied Sciences 11, no. 22 (2021): 10527. http://dx.doi.org/10.3390/app112210527.
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With increasing drug resistance of Pseudomonas aeruginosa, a new sterilization method is needed. Plasma has been shown to be an effective method of sterilization, but no researchers have studied the effect of plasma on bacterial metabolism. In this paper, we studied the emission spectrum, liquid phase active particles, and other physical and chemical properties of a portable plasma device. Pseudomonas aeruginosa were then treated with activated water generated by surface plasma discharge. Using gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, we obtained the differential metabolite pathways. The results showed that, after plasma activated water treatment, the carbohydrate metabolism of the bacteria was inhibited and the metabolic processes of protein and amino acid decomposition were enhanced. Therefore, water activated by atmospheric-pressure cold plasma can significantly change bacterial metabolites, thus promoting bacterial death.
Dissertations / Theses on the topic "Atmospheric Nitrogen Gas Plasma Sterilization"
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Tyl, Clémence. "Study of the memory effect in atmospheric pressure townsend discharges in nitrogen with addition of oxidizing gas : temporally and spatially resolved electrical and optical characterizations." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30296.
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Les procédés plasma utilisant des décharges à barrières diélectriques (DBD) à pression atmosphérique sont une bonne alternative aux plasmas froids à basse pression pour de nombreuses applications comme le traitement de surface, le dépôt de couches minces, la stérilisation etc. En effet, ils permettent de s'affranchir des systèmes de pompage et donc de réaliser des traitements sur de grandes surfaces directement implantables sur des lignes de production. Cependant, les DBD sont généralement filamentaires, ce qui conduit à des dépôts non homogènes. Dans certaines conditions expérimentales (géométrie, nature du gaz, excitation etc.), on peut néanmoins obtenir une décharge homogène conduisant à un traitement homogène des surfaces. Néanmoins, les caractéristiques des DBD homogènes ne sont pas identiques en tout point de l'espace, notamment en raison du flux de gaz, mais aussi dans le cas de matériaux diélectriques avec un gradient de propriétés ou dans le cas de décharges auto-organisées. Afin de mieux caractériser la distribution spatiale de la décharge, un outil de mesure de densités locales de courant a été développé au cours de cette thèse. En effet, les mesures électriques sont un bon outil de caractérisation de la décharge donnant accès à de nombreux paramètres (courant de décharge, tension gaz, puissance dissipée etc.). Néanmoins, le courant mesuré est intégré sur toute la surface des électrodes. Pour pouvoir mesurer les courants localement, l'électrode de masse de la cellule de décharge de dimension 3×3 cm2 a été divisée en 64 segments, et un système d'acquisition a été développé afin de pouvoir acquérir les 64 courants mesurés simultanément avec une fréquence d'échantillonnage suffisante pour le traitement des données. Ce nouvel outil de diagnostics électriques peut être corrélé temporellement et spatialement à des mesures optiques par caméra intensifiée iCCD couplée à différents filtres optiques, donnant des informations sur les densités de certaines espèces dans le plasma. L'objectif de cette thèse est de mieux comprendre la dissipation de puissance locale et de caractériser plus finement les espèces mises en jeu et les différents régimes de décharge, notamment l'obtention d'un régime homogène. Les DBD homogènes sont initiées par un claquage de type Townsend. Pour cela, une source de production d'électrons est nécessaire entre deux décharges, quand le champ électrique est inférieur au champ de claquage. Ce claquage est lié à un effet mémoire d'une décharge à l'autre, visible sur les mesures électriques, avec un saut du courant de décharge. Les hypothèses sur l'origine de cet effet mémoire peuvent être séparées en deux catégories.[...]<br>Plasma processes at atmospheric pressure using Dielectric Barrier Discharges (DBD) are a good alternative to low pressure non-thermal plasma processes for various applications such as surface treatment, thin-film coating, sterilization etc. Indeed, they can be operated without complex vacuum facilities and allow the treatment of large surfaces that can be implemented directly into assembly lines. However, DBDs are usually filamentary, leading to non-homogeneous depositions on the treated surfaces. In certain condition depending on the experimental parameters (geometry, gas nature, power supply, etc.), a homogeneous discharge can be obtained leading to a uniform surface treatment. Nevertheless, even in the homogeneous mode, the DBDs properties are not necessarily the same at any point on the discharge surface, because of the gas flow circulation in particular, but also in case of materials with a properties gradient, or in case of self-organization phenomena. In order to better characterize the spatial distribution of the discharge, a new local electrical diagnostic tool to measure the local current densities has been developed during this thesis. Indeed, electrical measurements are widely used to characterize the DBDs as they give access to various parameters such as the gas voltage, discharge current, dissipated power etc. However, the measured current is integrated on all the surface of the electrodes. To be able to measure the local currents, the 3×3 cm2 ground electrode from the discharge cell has been divided into 64 segments, and a data acquisition system has been developed in order to simultaneously acquire the 64 measured currents with a high enough sampling rate for the data processing. This new electrical diagnostic tool can be correlated in time and space with optical measurements with an intensified iCCD camera, coupled with optical filters, to obtain information on the densities of some species in the plasma. The aim of this thesis is to better understand to local power dissipation, and to refine the characterization of the involved species in the different discharge regimes, especially to obtain a homogeneous regime. Homogeneous DBDs are ignited by a Townsend breakdown. For a Townsend breakdown to occur, a production source of seed electrons is necessary between two discharges, when the electric field is lower than the breakdown voltage. This breakdown is related to a memory effect from one discharge to the following one, that is visible on the electrical measurements with a discharge current jump. The hypotheses on the memory effect origin can be separated into two categories.[...]
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Limam, Soukayna. "La bio décontamination de surface par plasma froid : Contribution par l’étude de procédés de traitement de surface à pression atmosphérique." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLC106.
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Dans le cadre de cette thèse, des travaux sur la bio décontamination de surface ont été entrepris, en s’intéressant tout particulièrement aux problématiques d’infections nosocomiales en milieu hospitalier. Dans cet objectif, deux sources de plasma froid ont été caractérisées et leurs effets biocides sur des micro-organismes tels qu’Escherichia coli et Bacillus stearothermophilus (micro-organismes de référence dans les procédures de stérilisation) ont été étudiés<br>Non thermal plasma technologies have recently been receiving attention as an alternative technology for surface decontamination of thermally sensitive medical materials. This work focuses on two atmospheric pressure discharges. Bacteria exposure (contaminated samples with Escherichia coli and Bacillus stearothermophilus ) and spectroscopic measurements were made simultaneously
Books on the topic "Atmospheric Nitrogen Gas Plasma Sterilization"
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Capitelli, M., C. M. Ferreira, and B. F. Gordiets. Plasma Kinetics in Atmospheric Gases. Springer, 2014.
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Capitelli, M., C. M. Ferreira, B. F. Gordiets, and A. I. Osipov. Plasma Kinetics in Atmospheric Gases (Springer Series on Atomic, Optical, and Plasma Physics). Springer, 2000.
Find full textBook chapters on the topic "Atmospheric Nitrogen Gas Plasma Sterilization"
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Shintani, Hideharu, Naohiro Shimizu, Yuichiro Imanishi, Akikazu Sakudo, Takuya Uyama, and Eiki Hotta. "Current Progress in Advanced Technology of Nitrogen Gas Plasma for Remote Sterilization and Clarification of Sterilization." In Gas Plasma Sterilization in Microbiology: Theory, Applications, Pitfalls and New Perspectives. Caister Academic Press, 2016. http://dx.doi.org/10.21775/9781910190258.04.
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Sakudo, Akikazu. "Current Progress in Advanced Research into the Inactivation of Viruses by Gas Plasma: Influenza Virus Inactivation by Nitrogen Gas Plasma." In Gas Plasma Sterilization in Microbiology: Theory, Applications, Pitfalls and New Perspectives. Caister Academic Press, 2016. http://dx.doi.org/10.21775/9781910190258.10.
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"Combinations with Cold Atmospheric Pressure Plasma Therapy." In Combination Therapies Involving Photodynamic Therapy. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781837672226-00274.
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Achieved under ambient conditions when a gas is passed through an electric field, cold plasma, consisting of reactive gas species, has found biomedical applications similar to those of photodynamic therapy; it kills cancer and bacterial cells and biofilms, and is effective in wound healing through infusion of the affected disease area with the reactive gas species. Most of these species are reactive oxygen and reactive nitrogen species, not unlike those generated in the type II mechanism of photodynamic therapy. This has created increasing interest in this rapidly growing therapeutic technology because it is effective and because the plasma can be administered directly against disease cells or the reactive gas species generated can be stored in suitable stabilizing media for subsequent administration. The technology has been combined with chemotherapy, electro-chemotherapy, magnetic and photothermal therapy, and photodynamic therapy for wound healing, tissue regeneration, wound closure, and bacterial antiseptic sanitization, together with an increasing number of non-invasive combination applications. It has stimulated the development of a wide range of clinical applicator devices. It has also been combined with electro-chemotherapy with additive enhancement of the efficacy of bone fracture rehabilitation. Enhancement of the efficacy of the combinations with photodynamic therapy may be rationalized in terms of the enhancement of reactive gas species. Immunotherapy combinations were demonstrated by the delivery of a checkpoint protein inhibitor and a cold atmospheric pressure plasma activated fluid directly to cancer xenografts using microneedles.
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"Basic Reflections on Cold Atmospheric Pressure Plasma Therapy." In Combination Therapies Involving Photodynamic Therapy. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781837672226-00103.
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When a pure gas or gas mixture is passed through an electrical field, of fixed or alternating amplitude, cold plasma is produced. Cold plasma is a charged gas that consists of electrons, radicals, ions and high energy light photons. It includes and has been compared to reactive oxygen and reactive nitrogen species using gas chromatography and emission spectroscopy. It is applied directly to disease sites such as cancerous lesions, bacterially infected wounds, and burns. There are two cold atmospheric pressure plasma device types. With indirect discharge, the active plasma species are carried by a gas flow from the discharge arcs. In direct discharge, the sample is one of the electrodes as an active part of the discharge. In indirect discharge, the sample is treated with a plasma jet. With direct discharge, the cold atmospheric pressure plasma will not be generated until the sample is close enough to the electrode. Therefore, the plasma jet device may be suitable for treating a small area on a sample, while, in contrast, the dielectric barrier discharge may be more suitable for a more intense treatment on a large area of a sample. Indirect treatment with cold atmospheric pressure plasma is achieved by application of a liquid medium, in which the components of the plasma are dissolved by first applying the plasma jet to the liquid medium. Antibacterial, antifungal, and antiviral applications have been reported, including SARS-CoV-2 viral and pneumococcus bacterial infections. Reports on combinations with photodynamic therapy are increasing.
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Shintani, Hideharu. "Current Progress in the Inactivation of Endotoxin and Lipid A by Exposure to Nitrogen Gas Plasma." In Gas Plasma Sterilization in Microbiology: Theory, Applications, Pitfalls and New Perspectives. Caister Academic Press, 2016. http://dx.doi.org/10.21775/9781910190258.05.
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Ruchel Khanikar, Rakesh, and Heremba Bailung. "Cold Atmospheric Pressure Plasma Technology for Biomedical Application." In Plasma Science and Technology. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.98895.
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Cold plasma generated in an open environment with a temperature nearly around room temperature has recently been a topic of great importance. It has unlocked the door of plasma application in a new direction: biomedical applications. Cold atmospheric pressure (CAP) plasma comprises various neutral and charged reactive species, UV radiations, electric current/fields etc., which have several impactful effects on biological matter. Some of the significant biological effects of CAP plasma are inactivation of microorganism, stimulation of cell proliferation and tissue regeneration, destruction of cells by initializing apoptosis etc. Although the detailed mechanism of action of plasma on biomaterials is still not completely understood, some basic principles are known. Studies have indicated that the reactive oxygen species and nitrogen species (ROS, RNS) play a crucial role in the observed biological effects. In this perspective, this chapter first provides a brief discussion on the fundamentals of CAP plasma and its generation methods. Then a discussion on the optical diagnostics methods to characterize the plasma is provided. Optical emission spectroscopy (OES) is used to identify the reactive species and to measure their relative concentration. Other important plasma parameters such as gas temperature, electron/excitation temperature and electron density measurement methods using OES have also been discussed. Then a discussion on the application of CAP plasma in biomedical field is provided. A thorough understanding of biochemical reaction mechanisms involving highly reactive plasma species will further improve and extend CAP plasma technology in biomedical applications.
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Yagyu, Yoshihito, and Akikazu Sakudo. "Current Technology and Applications of Gas Plasma for Disinfection of Agricultural Products: Disinfection of Fungal Spores on Citrus unshiu by Atmospheric Pressure Dielectric Barrier Discharge." In Gas Plasma Sterilization in Microbiology: Theory, Applications, Pitfalls and New Perspectives. Caister Academic Press, 2016. http://dx.doi.org/10.21775/9781910190258.11.
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Thiyagarajan Magesh, Sarani Abdollah, and Gonzales Xavier F. "Characterization of an Atmospheric Pressure Plasma Jet and its Applications for Disinfection and Cancer Treatment." In Studies in Health Technology and Informatics. IOS Press, 2013. https://doi.org/10.3233/978-1-61499-209-7-443.
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In this work an atmospheric pressure non-thermal resistive barrier (RB) plasma jet was constructed, characterized and was applied for biomedical applications. The RB plasma source can operate in both DC (battery) as well as in standard 60/50 Hz low frequency AC excitation, and it functions effectively in both direct and indirect plasma exposure configurations. The characteristics of the RB plasma jet such as electrical properties, plasma gas temperature and nitric oxides concentration were determined using voltage-current characterization, optical emission spectroscopy and gas analyzer diagnostic techniques. Plasma discharge power of 26.33 W was calculated from voltage-current characterization. An optical emission spectroscopy was applied and the gas temperature which is equivalent to the nitrogen rotational (Trot) temperatures was measured. The concentrations of the reactive oxygen species at different spatial distances from the tip of the plasma jet were measured and the ppm concentration of NO is at the preferred level for a wide range of standard biomedical treatment applications. The ppm values of nitric oxides after the cooling unit are observed to be of the same order of magnitude as compared to plasma jet. The portable RB plasma source was tested to be very effective for decontamination and disinfection of a wide range of foodborne and opportunistic nosocomial pathogens such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus and the preliminary results are presented. The effects of indirect exposure of the portable RBP source on monocytic leukemia cancer cells (THP-1) were also tested and the results demonstrate that a preference for apoptosis in plasma treated THP-1 cells under particular plasma parameters and dosage levels.
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Rasouli, Milad, Nadia Fallah, and Kostya (Ken) Ostrikov. "Lung Cancer Oncotherapy through Novel Modalities: Gas Plasma and Nanoparticle Technologies." In Lung Cancer - Modern Multidisciplinary Management. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95494.
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Cold atmospheric pressure plasma (CAP) is emerging as new healthcare technology and it has a high potential through physical and chemical effects for cancer treatment. Recently, CAP, plasma activated liquid (PAL), and nanomaterial have been significant advances in oncotherapy. Reactive oxygen-nitrogen species (RONS), electrical field, and other agents generated by CAP interact with cells and induce selective responses between the malignant and normal cells. Nanomedicine enhances therapeutic effectiveness and decreases the side effects of traditional treatments due to their target delivery and dispersion in tumor tissue. There are various nanocarriers (NCs) which based on their properties can be used for the delivery of different agents. The combination of gas plasma and nanomaterials technologies is a new multimodal treatment in cancer treatment, therefore, is expected that the conjunction of these technologies addresses many of the oncology challenges. This chapter provides a framework for current research of NC and gas plasma therapies for lung cancer. Herein, we focus on the application of gas plasmas and nanotechnology to drug and gene delivery and highlight several outcomes of its. The types and features of the mentioned therapeutics strategy as novel classes for treating lung cancer individually and synergistic were examined.
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M. Iqbal, Muhammad, and Mark M. Turner. "Interaction and Transport of Liquid Droplets in Atmospheric Pressure Plasmas (APPs)." In Fundamental Research and Application of Droplet Dynamics [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105010.
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The transport of liquid droplets in atmospheric pressure plasma (APP) has been recognized as a two-phase flow. The liquid droplet introduces a perturbation in APP and under several constraints, the behavior of this perturbation is not clear during transport. As soon as the droplets interact with the APP, they become charged, which causes the droplets to evaporate. Using 1D normalized fluid model, we first describe how the liquid droplets charge and interact with helium APP. The impact of this droplet-plasma interaction is then discussed and described using 2D coupled fluid-droplet model. The numerical modeling outcomes suggested that the evaporation of droplets has emerged as a primary mechanism in plasma; however, the mutual interactions, such as grazing and coalescence between the droplets, are dominant at higher precursor flow rates (>100 μl min−1). To demonstrate the importance of different liquid precursors during droplet-plasma interaction, we analyzed the spatiotemporal patterns of discharge plasma while considering the effects of HMDSO, n-hexane, TEOS, and water. Variable gas and liquid precursor flow rates are used to further examine the features of discharge plasma. Comparing penning ionization to other ionization processes, it is found to be the prime activity along the pulse of droplets, demonstrating the significance of small nitrogen impurities. Using a laser diffraction particle size analysis approach as part of an APP jet deposition system, the validation of the numerical simulations is proven by comparison with experimental observations of droplet size distributions.
Conference papers on the topic "Atmospheric Nitrogen Gas Plasma Sterilization"
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Kholodenko, V. P., V. A. Chugunov, I. A. Irkhina, et al. "Investigation of Influence of Biofilms on Microbiologically Induced Corrosion in Oil- and Gas-Processing Industries." In CORROSION 2005. NACE International, 2005. https://doi.org/10.5006/c2005-05496.
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Abstract Oil-and gas- pipelines and processing equipment are usually attacked by different microorganisms that can result with time in damage of the equipment leading to serious technological incidences and environmental contamination. The direction and speed of the processes responsible for bio-damages and bio-corrosion are determined by vital activity of microorganisms. Namely bio-films presenting complex associations of the microorganisms and their metabolites are among the main reasons providing such incidences. From other side, bio-films can be protective agents against corrosion as well. In this context, far and wide investigation of the role of biofilms in the development of bio-damages is relevant task. We have developed the method to culture biofilms on the surface of metallic coupons by using natural microbial consortium isolated from soils of oil-processing sites. There were aerobic heterotrophs, acid-producing and sulfate-reducing bacteria in the composition of the biofilm. Besides, simple and reliable methods for measuring microbiological parameters of biofilms to monitor biocorrosion processes were elaborated. Using these methods, we studied the dynamics of corrosion processes depending on quantitative and qualitative compositions of biofilms, aeration conditions and duration of experiments. It was shown that due to changing aeration conditions from microaerophilic to anaerobic, SRB grew better, thereby stimulating biocorrosion. At the same time, the biofilm cultured in the presence of kerosene as a sole source of carbon, produced a protective effect. The results obtained can be useful for an elaboration of new approaches to protect the pipelines and processing equipment against microbially induced corrosion and bio-damages, for instance by using the biocides. Additionally it was proved an existence of another effective approach for destroying the bio-films and sterilization of different surfaces (metallic and polymeric) sensitive to bio-damages and bio-corrosion. This method is based on the use of non-thermal (or cold) plasma created by gas discharge at atmospheric pressure either in ambient air (or other gases) or in liquids activated with gas bubbles. Plasma processing leads to total death of microorganisms constituting the biofilm. In particular, after a cycle of cold plasma treatment of liquid, more than 99.9% of bacteria of Bacillus sp. died.
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Matsui, Kei, Noriaki Ikenaga, and Noriyuki Sakudo. "Sterilization of microorganism spores with plasma-excited neutral gas at atmospheric pressure." In 2015 IEEE International Conference on Plasma Sciences (ICOPS). IEEE, 2015. http://dx.doi.org/10.1109/plasma.2015.7179789.
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Lin, Zhi-Hua, Jong-Shinn Wu, Chen-Yon Tobias Tschang, et al. "Development and Characterization of a Portable Atmospheric-Pressure Argon Plasma Jet for Sterilization." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-51117.
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In this study, we would like to develop a portable round argon atmospheric-pressure plasma jet (APPJ) which can be applied for general use of bacteria inactivation. The APPJ was characterized electrically and optically, which include measurements of absorption power, gas temperature and optical properties of plasma generated species. Measured OH* number density at 5 mm downstream was estimated to be 5.8 × 1015 cm−3 and the electron density and electron temperature were estimated to be 2.4 × 1015 cm−3 and 0.34 eV, respectively, in the discharge region. This APPJ was demonstrated to effectively inactivate E. coli within seconds of treatment, which shows its great potential in the future use of general bacteria inactivation and sterilization.
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Ermolaev, G. V., and A. V. Zaitsev. "IGNITION CONDITIONS OF A SINGLE BORON PARTICLE IN HOT GAS FLOW." In 8TH INTERNATIONAL SYMPOSIUM ON NONEQUILIBRIUM PROCESSES, PLASMA, COMBUSTION, AND ATMOSPHERIC PHENOMENA. TORUS PRESS, 2020. http://dx.doi.org/10.30826/nepcap2018-2-08.
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The basic experimental studies on boron combustion are done with the same general scheme of the experiment. Boron particles are injected into flat-flame burner products with the help of the transporting jet of cold nitrogen. Boron particle combustion process is registered with a number of optical methods. It is proposed that boron particle is injected into the main hot gas flow instantly, combustion takes place at the flame temperature and predefined oxygen concentration, and the influence of the transporting cold nitrogen jet is ignored. Recent combustion models are based mostly on this type of experiments and characterized with high complexity and low prediction level. In our study, we reconstruct the particle injection conditions for several basic experimental papers. It is shown that in all experimental setups, ignition, combustion, and even total particle burnout take place in the wake of the cold nitrogen jet. This zone is characterized with a much lower gas temperature and oxygen concentration than the main flat burner flow. The total temperature decrease can be about several hundred degrees, oxygen concentration can be 30%-50% lower than that used in the previous analysis of the experimental results. The temperatures of ignition and transition to the second stage of combustion are found with the help of the test particle trajectory and temperature tracking. It is shown that analysis of the influence of boron particles injection on gas temperature and oxygen concentration is mandatory for the development of future combustion models.
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КУЗНЕЦОВ, Н. М., С. Н. МЕДВЕДЕВ, С. М. ФРОЛОВ, Ф. С. ФРОЛОВ, Б. БАСАРА та К. ПАХЛЕР. "СВЕРХКРИТИЧЕСКОЕ ИСТЕЧЕНИЕ КРИОГЕННОЙ СТРУИ АЗОТА". У 9th International Symposium on Nonequilibrium Processes, Plasma, Combustion, and Atmospheric Phenomena. TORUS PRESS, 2020. http://dx.doi.org/10.30826/nepcap9b-27.
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Using the wide-range real-gas equation of state (EOS) of nitrogen, the gasdynamic calculations of the supercritical injection of a submerged turbulent jet of cryogenic nitrogen into a chamber filled with nitrogen at normal temperature are performed. The results of calculations are compared with available experimental data on nitrogen density variation in the jet. Satisfactory agreement of the results is obtained.
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KUZNETSOV, N. M., S. N. MEDVEDEV, S. M. FROLOV, F. S. FROLOV, B. BASARA, and K. PACHLER. "THERMAL AND CALORIC EQUATIONS OF STATE FOR NITROGEN: APPLICATION TO CRYOGENIC INJECTION CONDITIONS." In 9TH INTERNATIONAL SYMPOSIUM ON NONEQUILIBRIUM PROCESSES, PLASMA, COMBUSTION, AND ATMOSPHERIC PHENOMENA. TORUS PRESS, 2020. http://dx.doi.org/10.30826/nepcap9a-44.
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The real-gas analytical equation of state (EoS) for nitrogen is developed. The applicability domain of the EoS is verified in a wide range of density (from 0 to the value at the triple point, 0.867 g/cm3) and temperature (from 100 to 5000 K). The obtained EoS is introduced into the gasdynamic code for calculating multidimensional turbulent reactive flows.
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Andoh, Y., S. Tobe, H. Tahara, and T. Yoshikawa. "Nitriding of Titanium Plate and Atmospheric Plasma Sprayed Titanium Coating using Nitrogen Plasma Jets Under a Low Pressure Environment." In ITSC 1999, edited by E. Lugscheider and P. A. Kammer. Verlag für Schweißen und verwandte Verfahren DVS-Verlag GmbH, 1999. http://dx.doi.org/10.31399/asm.cp.itsc1999p0234.
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Abstract In this paper, as a basic study of the plasma jet process under a low pressure, the nitriding of titanium plates and atmospheric plasma sprayed titanium coatings are carried out using nitrogen and hydrogen added nitrogen plasma jets at 30Pa. The plasma torch used in this paper is equipped with a supersonic expansion nozzle to improve the acceleration efficiency of plasma jets. The effects of ambient pressures and supersonic expansion nozzles on transformation of plasma particles are examined from gas-dynamical viewpoints. It was observed that from the results, the supersonic plasma jet process under a low pressure was proved to have a high potential for nitriding. Paper includes a German-language abstract.
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Birk, Luka, Ita Junkar, and Ksenija Rener-Sitar. "Use of Gaseous Plasma for Dental Applications." In Socratic lectures 10. University of Lubljana Press, 2024. http://dx.doi.org/10.55295/psl.2024.i15.
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Abstract: Plasma technology is a rapidly growing field of science that permeates various branches of medicine and dental medicine. In dental medicine, cold or nonthermal gaseous plasma can be used directly in the oral cavity for the surface treatment of hard dental tissues, periodontal tissues, or oral mucosa or indirectly for treating dental ma-terials before intraoral use or placement. Simplified atmospheric-pressure plasma de-vices in plasma pencils or jets have broadened the spectrum of plasma technology ap-plications for safe plasma treatment of living tissues. Cold gaseous plasma also allows surface treatment of various heat-sensitive materials. Dental alloys, polymers, waxes, and ceramics can be decontaminated or disinfected with plasma treatment. Antimi-crobial properties of cold atmospheric plasma have been demonstrated to facilitate the treatment of oral mucosa infections, dental caries, and endodontic space infections. Various dental materials can also be functionalized through plasma surface treatment to improve their biocompatibility, adhesive properties, wettability, or permeability. Promising results of cold plasma treatment have also been shown in the bleaching of teeth with external or internal staining and the enhancement of the adhesion of dental composites to dentin. Plasma may also serve as a method of dental armamentarium cleaning and sterilization. Although the use of cold gas plasma is not yet part of the standard procedures in the daily clinical practice of dentists, promising results from preclinical and clinical research are encouraging further development and exploration of this technology. Keywords: cold gaseous plasma; atmospheric pressure plasma; plasma technology; dental medicine; surface treatment
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Bulat, P. V., M. P. Bulat, P. V. Denissenko, V. V. Upyrev, and I. A. Volobuev. "MULTIFOCAL IGNITION OF COMBUSTION CHAMBER BY SUBCRITICAL STREAMER MICROWAVE DISCHARGE." In 8TH INTERNATIONAL SYMPOSIUM ON NONEQUILIBRIUM PROCESSES, PLASMA, COMBUSTION, AND ATMOSPHERIC PHENOMENA. TORUS PRESS, 2020. http://dx.doi.org/10.30826/nepcap2018-2-17.
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The challenges facing engine developers, aimed at improving the technical and operational characteristics, more stringent environmental standards, make the work aimed at increasing the efficiency of ignition, systems highly relevant. Technologies of prechamber, arc ignition, and ignition by corona discharge known to date require significant energy costs. In addition, ignition of a fuel mixture by such systems is local which leads to the limitation in the burning rate, incomplete combustion of fuel, and formation of harmful impurities in combustion products. Volumetric or multipoint ignition may significantly increase the effectiveness of the use of ignition systems. The use of a subcritical streamer microwave discharge, which is a network of thin hot channels propagating in the volume of the combustion chamber, seems promising because it provides virtually instantaneous ignition of the mixture in the entire volume. In this paper, the results of experiments using a subcritical streamer microwave discharge are presented. The possibility of volumetric ignition and a substantial increase in the completeness of fuel combustion is demonstrated. A number of indirect evidences indicate the absence of nitrogen oxides in combustion products. The results can be applied to the development of multivolumetric ignition systems in internal combustion engines, gas pumping units, power gas turbines, low-emission combustion chambers, etc.
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Czernichowski, Albin, Piotr Czernichowski, and Krystyna Wesolowska. "Plasma-Catalytical Partial Oxidation of Various Carbonaceous Feeds Into Synthesis Gas." In ASME 2004 2nd International Conference on Fuel Cell Science, Engineering and Technology. ASMEDC, 2004. http://dx.doi.org/10.1115/fuelcell2004-2537.
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We propose a sulfur-resistant process in which a gaseous or liquid carbonaceous matter is converted into the Synthesis Gas in a presence of high-voltage cold-plasma (“GlidArc”) that assists the exothermal Partial Oxidation. This process is performed in our 0.6 to 2-Liter reactors using atmospheric air. The reactants are mixed at the reactor entry without use of vaporizers or nozzles. Our process is initiated in the discharges’ zone in presence of active electrons, ions, and radicals generated directly in the entering mixture. Then the partially reacted steam enters a post-plasma zone of the same reactor. This zone is filled with a metallic and/or mineral material. We found several solids that present some catalytic properties enhanced by high temperatures and active species generated in the cold plasma. Atmospheric pressure reforming is presently studied. This paper recalls our earlier tests with natural gas, propane, cyclohexane, heptane, toluene, various gasolines, diesel oils (including logistic ones), and the Rapeseed oil. New experiments are then presented on the reforming of heavy naphtha and an aviation fuel. The synthesis gas issued from the last one has been successfully converted into electric energy in an on-line inserted Solid Oxide fuel Cell. All tested feeds are totally reformed into Hydrogen, Carbon Monoxide and some Methane. Other components are Steam and Carbon Dioxide. All these products are diluted in Nitrogen coming from the air. No soot, coke or tars are produced even from highly aromatic liquids. The output Synthesis Gas power issued as the result of our tests can presently reach 11 kW (accounted as the Lower Heating Value of produced H2 + CO stream). Only 0.05–0.2 kW of electric power is necessary to drive such cold-plasma-assisted reformer. Up to 45 vol.% of H2 + CO mixture (dry basis) is produced in long runs. We obtain a better than 70% thermal efficiency of the process (defined as the output combustion enthalpy of H2 + CO at 25°C concerning the Lower Heating Value of the feed). However a large part of remaining percentage of the energy leaving the reformer (the sensitive heat and CH4 at 2–3 vol.% level) can be further reused in the high-temperature Fuel Cells.