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Dissertations / Theses on the topic 'ATP extracellulare'

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Published: 9 March 2023

Last updated: 31 July 2025

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1

PEGORARO, ANNA. "The P2X7 receptor modulates extracellular ATP levels cell to cell communication and chemoresistance in oncogenesis." Doctoral thesis, Università degli studi di Ferrara, 2020. http://hdl.handle.net/11392/2488306.

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ATP accumulates in the tumour microenvironment (TME) and via its receptor P2X7 is involved in immune response, cancer proliferation and metastasis formation. In this study we investigated ATP release, P2X7 expression and its function in acute myeloid leukemia (AML) and melanoma. In an in vivo AML model, treatment with daunorubicin causes the release of ATP in TME that is associated to tumour eradicating immune response. When we analysed the two functional P2X7 isoforms (P2X7A and P2X7B) in an AML population we observed that they are both overexpressed in patients affected by AML as compared to

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2

Thomas, Collin Ernest. "Extracellular ATP : transport, metabolism, and physiological significance /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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3

Kim, Sung-Yong Stacey Gary. "Extracellular ATP, apyrase and nodulation of non-legumes." Diss., Columbia, Mo. : University of Missouri--Columbia, 2008. http://hdl.handle.net/10355/7189.

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Title from PDF of title page (University of Missouri--Columbia, viewed on February 24, 2010). The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. Dissertation advisor: Dr. Gary Stacey. Vita. Includes bibliographical references.

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4

Morrison, Matthew Sam. "Osteoclast function : role of extracellular pH and ATP." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369218.

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5

McCarthy, C. "Extracellular ATP signalling pathways in detrusor smooth muscle." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444817/.

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Two neurotransmitters, ACh and ATP, initiate nerve-mediated contractions in detrusor smooth muscle from guinea-pigs and humans with bladder over-activity whereas only ACh has a role in muscle from stable human bladders. Both Acetylcholine and ATP are rapidly broken down, by acetylcholinesterases and ectonucleotidases respectively. The activity of ectonucleotidase has been shown to be reduced in the unstable human detrusor compared to stable. The reduced activity may contribute to the development of the purinergic component of the unstable human detrusor contraction. In vitro muscle strip exper

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6

VUERICH, Marta. "Extracellular ATP modulates Myeloid Derived Suppressor Cells functions." Doctoral thesis, Università degli studi di Ferrara, 2014. http://hdl.handle.net/11392/2389384.

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The main obstacle to the success of the immunotherapy is the well established tumor-induced tolerance. In 2007 a new cell population, Myeloid Derived Suppressor Cells (MDSCs), that accumulate under inflammatory conditions, especially in cancer, was identified. These cells are potent inhibitors of tumor immunity and are now considered a major contributor to the failure of the immunotherapy. Understanding the exact mechanism of immunosuppressive activity of MDSC is a crucial point in order to find new ways to improve anticancer therapies. In the last years several models of MDSC functions were

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7

Stevens, Beth. "Activity-dependent regulation of Schwann cell development by extracellular ATP." College Park, Md. : University of Maryland, 2003. http://hdl.handle.net/1903/91.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2003.<br>Thesis research directed by: Biology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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8

Hansson, Bergén Mattias. "ADENOSINTRIFOSFAT (ATP) SOM EXTRACELLULÄR SIGNALMOLEKYL I KOLONCANCERCELLINJEN HT-29." Thesis, Örebro universitet, Institutionen för läkarutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-36989.

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9

Lee, Jee Yeon. "ABCA1 Increases Extracellular ATP to Mediate Cholesterol Efflux to ApoA-I." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20519.

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ABCA1 is a key plasma membrane protein required for the efflux of cellular cholesterol to extracellular acceptors, particularly to apoA-I. This process is essential to maintain cholesterol homeostasis in the body. The detailed molecular mechanisms, however, are still insufficiently understood. Also, the molecular identity of ABCA1, i.e. channel, pump or flippase, remains unknown. In this study we analyzed the extracellular ATP levels in the medium of ABCA1-expressing BHK cells and RAW macrophages and compared them to the medium of relevant non-expressing cells. We found that the extracellular

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10

Parry, James. "Tissue transglutaminase & tumour progression : cell death & extracellular matrix stabilisation." Thesis, Nottingham Trent University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251267.

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11

Troadec, Jean-Denis. "Regulation du couplage stimulus-secretion par l'atp extracellulaire dans la neurohypophyse de rat." Nice, 1998. http://www.theses.fr/1998NICE5230.

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L'atp, molecule intracellulaire fondamentale du metabolisme energetique, peut egalement avoir un role de mediateur intercellulaire. Ses actions comme neurotransmetteur sont bien etablies au niveau du snp, alors que peu de donnees sont disponibles au niveau du snc. La neurohypophyse est un organe neuroendocrinien constitue principalement de terminaisons neurosecretrices et de cellules gliales appelees pituicytes. Nous avons etudie l'effet de l'atp extracellulaire sur deux modeles complementaires : les terminaisons nerveuses isolees et les pituicytes en culture primaire. L'atp entraine une augme

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12

Desuzinges-Mandon, Elodie. "Rôle du domaine extracellulaire d’ABCG2 dans l’homéostasie des porphyrines." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10236/document.

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ABCG2 est un transporteur de la famille ABC impliqué dans le phénotype de résistance aux drogues développé par certaines cellules, par exemple les cellules cancéreuses. Ce transporteur a aussi un rôle physiologique de détoxication de composés endogènes, notamment les porphyrines, molécules indispensables mais qui présentent une toxicité potentielle. Cette toxicité nécessite une prise en charge particulière, évitant à ces composés d’être libres en solution. Dans ce contexte, nous avons fait l’hypothèse qu’ABCG2 pourrait participer à cette détoxication en limitant l’accumulation des porphyrines

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13

Abu, Ali Rola. "Micromorphology of extracellular mucilage in wood decay fungi." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300442.

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14

Kelly, Douglas Robert. "The effect of extracellular ATP on spontaneous calcium waves in isolated rat cardiomyocytes /." Title page and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09SB/09sbk2963.pdf.

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15

Tome, Daniel Filipe Araujo. "Investigations into extracellular ATP signalling and FB1-induced cell death in Arabidopsis thaliana." Thesis, Durham University, 2011. http://etheses.dur.ac.uk/3356/.

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Extracellular ATP (eATP) is an important signalling molecule involved in regulation of plant growth and development, interactions with other organisms and responses to several environmental stimuli. The molecular targets mediating the physiological effects of eATP in plants remain to be identified. The work presented in this thesis focuses on identifying the signalling components that underlie the physiological roles of eATP in plants, with a strong emphasis on cell death control. An Arabidopsis thaliana (Arabidopsis) cell culture system combined with 2-dimensional difference in-gel electropho

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16

Ekokoski, Elina. "Extracellular ATP as a regulator of intracellular signaling in thyroid FRTL-5 cells." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/ekokoski/.

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17

Cardouat, Guillaume. "Rôle de l’autophagie et du métabolisme nucléotidique extracellulaire dans la régulation de la voie ecto-F1-ATPase d’endocytose des HDL." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30215.

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L'effet protecteur des HDL sur les pathologies cardio-vasculaires est principalement attribué à leur rôle central dans le Transport Retour du Cholestérol (TRC). Ce processus assure l'efflux du cholestérol excédentaire des cellules périphériques vers le foie, au niveau duquel il est éliminé dans les sécrétions biliaires. Dans ce contexte, notre équipe a identifié à la surface des cellules hépatiques la présence d’un complexe enzymatique, très proche de l’ATP synthase mitochondriale, comme étant un récepteur de haute affinité pour l’apoA-I (protéine majoritaire des HDL). Cette ATP synthase de su

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18

Kagenishi, Tomoko [Verfasser]. "Extracellular ATP Signaling is Linked to Endocytic Vesicle Recycling in Root Apex / Tomoko Kagenishi." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1133543170/34.

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19

Eldred, Julie Ann. "Role of extracellular ATP and adenosine in the human lens and retinal pigment epithelium." Thesis, University of East Anglia, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405383.

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Purpose: To detennine the potential impact through signalling, that A TP and its metabolites have on lenticular and retinal ceJJs. To achieve this, I aimed to detennine the levels of ATP and its metabolites in human ocular fluids and to examine the etTect of environmental stress on release of A TP and its metabolites into the extracellular medium. I also aimed to identify functional roles for A TP and its metabolites and for this end I studied growth control and activation of intraceJJular signalling pathways Methods: Two cell-lines were routinely cultured and used for these studies: FHL-124 a

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20

Gazzerro, Elisabetta [Verfasser]. "Role of Extracellular ATP in the Progression of Muscle Damage in Sarcoglycanopathies / Elisabetta Gazzerro." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2021. http://d-nb.info/1234982528/34.

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21

Chen, Christopher S. (Christopher Sao Bing). "Cell shape & integrins : determinants of extracellular matrix regulation of growth & survival." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/96448.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Whitaker College of Health Sciences and Technology, 1997.<br>Includes bibliographical references (leaves 201-215).<br>by Christopher S. Chen.<br>Ph.D.

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22

Burton, S. M. "Investigation of extracellular proteases produced by Beauveria bassiana." Thesis, Cranfield University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339884.

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23

Adriouch, Sahil. "Immunorégulation par le NAD extracellulaire : activation via les ADP-ribosyl transférases du récepteur cytolytique P2X7." Paris 7, 2003. https://tel.archives-ouvertes.fr/tel-00003698.

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De nombreux récepteurs aux purines ont été caractérisés à la surface des cellules de mammifères. Ces récepteurs sont impliqués dans la régulation de multiples fonctions biologiques mais leur participation dans la mise en place de la réponse immune reste encore à clarifier. Sur les cellules de l'immunité, il existe en plus des récepteurs purinergiques P1 sensibles à l'adénosine et P2 sensibles à l'ATP, des enzymes membranaires ayant pour substrat le NAD. Ces enzymes sont des NAD-glycohydrolases et ADP-ribose cyclases comme CD38 et CD157 et des mono ADP-ribosyl transférases (ART), apparentées à

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24

Wang, Xuan. "Internalization of Extracellular ATP by Cancer Cells and its Functional Roles in Cancer Drug Resistance." Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1505834714683835.

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25

Boyd, Tressler Andrea Michelle. "MECHANISMS OF EXTRACELLULAR NUCLEOTIDE ACCUMULATION DURING REGULATED CELL DEATH IN TUMOR CELLS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459441520.

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26

Bours, Martijn Jan Leo. "Role of extracellular ATP in immunity and intestinal defence effects on intestinal permeability and enterocyte-driven inflammatory response /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Universiteit Maastricht [host], 2007. http://arno.unimaas.nl/show.cgi?fid=9328.

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27

Ramanathan, Saumya. "Extracellular Regulation of Nitric Oxide Signaling via Soluble Guanylate Cyclase." Diss., The University of Arizona, 2012. http://hdl.handle.net/10150/223312.

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Nitric Oxide (NO) regulates cardiovascular homeostasis by binding to soluble guanylate cyclase (sGC), leading to cGMP production, reduced cytosolic calcium concentration ([Ca²⁺]ᵢ) and vasorelaxation. Thrombospondin-1 (TSP-1), a secreted matricellular protein, was recently discovered to inhibit NO signaling and sGC activity. Inhibition of sGC requires binding to cell-surface receptor CD47. Here, I show that a TSP-1 C-terminal fragment (E3CaG1) readily inhibits sGC in Jurkat T cells, and that inhibition requires an increase in [Ca²⁺]ᵢ. Using digital imaging microscopy on live cells, I furthe

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28

Cao, Yanyang. "Roles of Extracellular ATP in Induction of Epithelial-Mesenchymal Transition and Other Early Steps of Metastasis." Ohio University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou156984033112675.

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29

Mandon, Elodie. "Rôle du domaine extracellulaire d'ABCG2 dans l'homéostasie des porphyrines." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00868903.

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ABCG2 est un transporteur de la famille ABC impliqué dans le phénotype de résistance aux drogues développé par certaines cellules, par exemple les cellules cancéreuses. Ce transporteur a aussi un rôle physiologique de détoxication de composés endogènes, notamment les porphyrines, molécules indispensables mais qui présentent une toxicité potentielle. Cette toxicité nécessite une prise en charge particulière, évitant à ces composés d'être libres en solution. Dans ce contexte, nous avons fait l'hypothèse qu'ABCG2 pourrait participer à cette détoxication en limitant l'accumulation des porphyrines

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30

Hughes, Zoe Alexandra. "Modulation of extracellular noradrenaline in rate cortex by selective serotonin reuptake inhibitors (SSRIs)." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300168.

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31

Vincent-Héroux, Jonathan. "Extracellular matrix receptors in astrogliosis." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32608.

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Dystroglycan and the integrins are two types of extracellular matrix receptors involved in astrocyte adhesion and migration. The molecular mechanisms that control their distribution to signaling platforms of the plasma membrane remain poorly understood. In the present study, we define four cell spreading stages for adherent astrocytes, termed stage 1 to 4, and defined by the state of spreading of the cell in culture. Immunocytochemistry analysis reveals that DG and integrins distribute differentially depe

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32

El, Moatassim Billah Chakib. "Actions de l'adénosine 5'-Triphosphate (ATP) extracellulaire sur les lymphocytes murins : implication de récepteurs spécifiques à l'ATP4̄." Montpellier 2, 1990. http://www.theses.fr/1990MON20033.

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Nous avons vu au cours de ce travail que l'atp extracellulaire augmente la (ca#2#+)i dans les thymocytes de souris et stimule la blastogenese de la population medullaire (mature) traitee au pma. L'atp induit la formation et l'excretion de l'interleukine-2 (il2) et l'accumulation de l'il2 dans les surnageants de cellules stimulees est parallele a la proliferation cellulaire. Ce resultat suggere que la proliferation des thymocytes medullaires matures stimulee par l'atp opere par la voie connue de l'il2. L'augmentation de la (ca#2#+)i induite par l'atp est rapide, dose-dependante, strictement dep

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33

Qian, Yanrong. "Internalization of Extracellular ATP in Cancer Cells and Development of New Generations of Anticancer Glucose Transport Inhibitors." Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1416411921.

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34

Prosdocimo, Domenick A. "Extracellular Pyrophosphate Homeostasis and Regulation of Vascular Calcification in Vascular Smooth Muscle Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1266605413.

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35

ADRIOUCH, Sahil. "Immunorégulation par le NAD extracellulaire : activation via les ADP-ribosyl transférases du récepteur cytolytique P2X7." Phd thesis, Université Paris-Diderot - Paris VII, 2003. http://tel.archives-ouvertes.fr/tel-00003698.

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De nombreux récepteurs aux purines ont été caractérisés à la surface des cellules de mammifères. Ces récepteurs sont impliqués dans la régulation de multiples fonctions biologiques mais leur participation dans la mise en place de la réponse immune reste encore à clarifier. Sur les cellules de l'immunité, il existe en plus des récepteurs purinergiques P1 sensibles à l'adénosine et P2 sensibles à l'ATP, des enzymes membranaires ayant pour substrat le NAD. Ces enzymes sont des NAD-glycohydrolases et ADP-ribose cyclases comme CD38 et CD157 et des mono ADP-ribosyl transférases (ART), apparentées à

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36

Cardouat, Guillaume. "Rôle de l’autophagie et du métabolisme nucléotidique extracellulaire dans la régulation de la voie ecto-F1-ATPase d’endocytose des HDL." Electronic Thesis or Diss., Toulouse 3, 2017. http://www.theses.fr/2017TOU30215.

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L'effet protecteur des HDL sur les pathologies cardio-vasculaires est principalement attribué à leur rôle central dans le Transport Retour du Cholestérol (TRC). Ce processus assure l'efflux du cholestérol excédentaire des cellules périphériques vers le foie, au niveau duquel il est éliminé dans les sécrétions biliaires. Dans ce contexte, notre équipe a identifié à la surface des cellules hépatiques la présence d’un complexe enzymatique, très proche de l’ATP synthase mitochondriale, comme étant un récepteur de haute affinité pour l’apoA-I (protéine majoritaire des HDL). Cette ATP synthase de su

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37

Oliveira, Ludmila Corrêa Guimarães de. "Participação dos receptores de angiotensina II AT1 e AT2 no núcleo central da amígdala sobre a ingestão de sódio." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/8005.

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Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2017-11-30T11:54:27Z No. of bitstreams: 2 Dissertação - Ludmila Corrêa Guimarães de Oliveira - 2017.pdf: 1800128 bytes, checksum: 54cb8a55b9534c5187510046f3a4c8b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-11-30T12:52:29Z (GMT) No. of bitstreams: 2 Dissertação - Ludmila Corrêa Guimarães de Oliveira - 2017.pdf: 1800128 bytes, checksum: 54cb8a55b9534c5187510046f3a4c8b4 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f0

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Sano, Takeshi. "Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP." 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225467.

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39

Corinaldi, Jaime. "Troglitazone induces extracellular matrix & cytoskeleton remodeling in the IMCD-K2 & M1 renal collecting duct cell lines." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28122.

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TGF-beta activation has been inhibited with Troglitazone, a synthetic PPARgamma ligand (Peng, Liu et al. 2006). The fibrotic response in the collecting ducts of the nephron, particularly in terms of EMT, has only recently been established (Ivanova, Butt et al. 2008). The purpose of this study was to characterize a fibrotic response in the collecting duct with TGF-beta and to assess PPARgamma's role in the phenomenon. We hypothesized PPARgamma activation will have a protective effect in the collecting duct, preventing TGF-beta mediated EMT. TGF-beta was unable to initiate a fibrotic response in

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40

Mas, del Molino Ezequiel. "Is the extracellular ATP a key in X-linked Charcot-Marie-Tooth disease and in inherited non-syndromic deafness?" Doctoral thesis, Universitat de Barcelona, 2011. http://hdl.handle.net/10803/32018.

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El ATP es una molécula ampliamente conocida por su papel en muchas funciones como la homeostasis celular, el mantenimiento de gradientes iónicos, el mantenimiento del pH en gránulos secretores, el almacenamiento energético, regulador de la interacción actina-miosina, etc. Además, el ATP puede actuar como molécula señalizadora a través de los receptores purinérgicos P2. De receptores P2 hay de dos tipos, los P2X, que son ionotrópicos, y los P2Y que son metabotrópicos. Los primeros son una familia de canales iónicos permeables a cationes que se abren cuando se les une el ATP. Los segundos son re

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41

Wang, He 1965. "Extracellular matrix metabolism in injury-induced atherosclerosis." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40277.

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Remodelling of extracellular matrix (ECM) is a prominent feature of atherosclerotic lesions and contributes to lipoprotein retention as well as smooth muscle cell (SMC) activation. To gain further knowledge about ECM, certain ECM components and their degrading enzymes were studied in injury-induced arterial neointima, which shares features with early atherosclerotic lesions.<br>It has been shown that synthesis of collagen and syndecan-1, a hybrid heparan/chondroitin sulfate proteoglycan, is enhanced. In situ hybridization indicates that syndecan positive cells are restricted to the arterial ne

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42

Edginton, Ryan Stuart. "The multiscale biomechanics and mechanochemistry of the extracellular matrix protein fibres, collagen & elastin." Thesis, University of Exeter, 2018. http://hdl.handle.net/10871/34619.

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Collagen is the most abundant protein in the animal kingdom and, together with elastin, forms extensive fibrous networks that constitute the primary structure of the mammalian extracellular matrix, respectively endowing it with the tensile and elastic properties that fulfil its principal role as the passive framework of the body. The fibrous proteins are distinctly hierarchically organised from the molecular scale upwards; for example, the nanoscale tropocollagen monomer assembles in arrays that form the micrometer scale microfibrils and fibrils, and thence into collections of millimetre scale

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43

Rogman, Alberic. "The role of plasmin in estrogen-mediated extracellular matrix remodeling in the rat uterus." Click here for download, 2008. http://proquest.umi.com/pqdweb?did=1574153011&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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44

Lochter, André. "Control of neuronal differentiation by extracellular matrix constituents /." [S.l.] : [s.n.], 1993. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10325.

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45

Evers, Maria Danielle. "Extracellular ATP as an emerging master inducer and regulator of epithelial to mesenchymal transition (EMT) in human lung cancer cells." Ohio University Honors Tutorial College / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1587744041884785.

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46

Garcia, John Francis. "The role of extracellular matrix proteins in epithelial tumorigenesis /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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47

Pruitt, Freddie Lee III. "Chemoresistance of prostate cancer cells to docetaxel is modified by extracellular matrix substratum." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 92 p, 2008. http://proquest.umi.com/pqdweb?did=1459903001&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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48

Fan, Xiaolian. "Investigation of extracellular esterase activities from thermophilic fungi, and purification and characterization of novel small enzymes." Thesis, University of Strathclyde, 2001. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21421.

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The existence of naturally occurring, very small enzymes (<10 kDa, microenzymes) has been established with the findings that some enzyme activities are associated with proteins smaller than 10 kDa. This work investigated the extracellular esterase activities observed in some thermophilic fungi, and purified and characterised three novel thermostable microenzymes with esterase activities. Among the nine thermophilic fungi studied, two esterase-positive organisms, Emericella nidulans and Talaromyces emersonii, exhibited the enzyme activities in less than 10 kDa fraction when grown in either malt

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Lee, Hojoon. "On the extracellular network of interacting proteins that patterns the embryonic dorsal-ventral axis." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1317324081&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Bijian, Krikor. "Extracellular matrix regulates glomerular epithelial cell survival and proliferation." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85130.

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Abstract:

Glomerular epithelial cells (GECs) are intrinsic components of the kidney glomerulus and are in contact with extracellular matrix (ECM). Under normal conditions, there is little turnover of GECs, but in glomerular injury, apoptosis and proliferation of GECs, and expansion of ECM may lead to sclerosis and impaired glomerular function and/or permselectivity. In order to better understand how adhesion to ECM modulates GEC survival and proliferation, we monitored the activation of the intracellular signaling pathways activated by adhesion to ECM (collagen), along with their coordinate modul

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