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1

Tavares, K. A., and K. M. Silva. "Evaluation of Power Transformer Differential Protection Using the ATP Software." IEEE Latin America Transactions 12, no. 2 (2014): 161–68. http://dx.doi.org/10.1109/tla.2014.6749533.

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2

Aditya Pandey, Sachin Tiwari,. "Current Transformer Sizing & Saturation Calculation with Transient Performance Analysis of CT Using ATP Software." International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering 04, no. 05 (2015): 3853–60. http://dx.doi.org/10.15662/ijareeie.2015.0405009.

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3

Aditya Pandey, Sachin Tiwari,. "Current Transformer Sizing & Saturation Calculation with Transient Performance Analysis of CT Using ATP Software." International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering 04, no. 05 (2015): 3911–18. http://dx.doi.org/10.15662/ijareeie.2015.0405018.

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4

Colqui, Jaimis Sajid Leon, Luis Carlos Timana Eraso, Pablo Torrez Caballero, Jose Pissolato Filho, and Sergio Kurokawa. "Implementation of Modal Domain Transmission Line Models in the ATP Software." IEEE Access 10 (2022): 15924–34. http://dx.doi.org/10.1109/access.2022.3146880.

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5

Jasika, Ranko, Jovan Mrvic, Ninoslav Simic, and Ljubisa Cickaric. "Optimization of dynamic MOSA model parameters using ATP/EMTP software tool." Zbornik radova, Elektrotehnicki institut Nikola Tesla 27, no. 27 (2017): 47–56. http://dx.doi.org/10.5937/zeint27-15534.

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6

Banjanin, Mladen, Urban Taljan, Peter Kanduč, Matevž Lavtar, and Boško Radović. "EMTP-ATP and MATLAB-Based Parameter Variation Calculations – Case Study of Lightning Protection of 110 kV Substation at the Wind Park." B&H Electrical Engineering 19, no. 1 (2025): 45–51. https://doi.org/10.2478/bhee-2025-0007.

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Abstract Detection of the worst-case scenario and calculation of the highest amplitudes of lightning transients in different points of analysed system is important in lightning-related calculations. In the software EMTP-ATP, this can be done using the parameters variation calculation, which results in hundreds or thousands of output files containing the calculated results. Analyses and graphical presentations of such results in the software EMTPATP are complicated and time-consuming. This paper presents the solution to this problem based on MATLAB software. The application of the implemented procedure is illustrated in the example of lightning protection of the 110 kV substation at the wind park against transients caused by direct lightning strikes into the connected overhead line. Software EMTP-ATP is used to make the parameters variation calculations, while software MATLAB is used to analyse and graphically present the calculated results.
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7

Vujević, Slavko, and Petar Sarajčev. "Dangerous Voltages due to Direct Lightning Strike into the Communication Tower." Journal of Communications Software and Systems 3, no. 1 (2007): 44. http://dx.doi.org/10.24138/jcomss.v3i1.268.

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This paper presents a novel technique for computing dangerous voltages due to direct lightning strike into the communication tower and associated earthing system, which is based on the use of the well-known ATP-EMTP software package. The earthing grid and the communication tower structure are approximated by the circular cross section conductors. In numerical model, conductors are subdivided into segments (1D finite elements) and Clark's model with distributed constant parameters is then applied. Because of the limitations of ATP-EMTP software package, the leakage resistance of buried segments is modelled as additional lumped parameter. Analytical expressions for distributed and lumped segment parameters are derived using the average potential method. Mutual electromagnetic coupling between segments is neglected due to the limitations imposed by the ATP-EMTP software package, which is based on transmission line approach. Separate computer program is developed for obtaining the earth surface transient potential distribution, from which step and touch voltages are then computed.
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Preobrazhenskaya, Y. V., A. I. Stenko, M. V. Shvarts, and V. Y. Lugovtsev. "Binding Stoichiometry of a Recombinant Selenophosphate Synthetase with One Synonymic Substitution E197D to a Fluorescent Nucleotide Analog of ATP, TNP-ATP." Journal of Amino Acids 2013 (January 30, 2013): 1–8. http://dx.doi.org/10.1155/2013/983565.

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The transformation of the strain DH5αTM-T1R with plasmid vector pET11a containing the cloned gene of bacterial selenophosphate synthetase (SPS), selD, from the E. coli BL21-Gold (DE3) strain gives an overproducing strain of SPS with one synonymic substitution, E197D. The transformation efficiency was estimated as 8 × 108 CFU/μg plasmid DNA. 28 mg of highly purified preparation of recombinant SPS capable of binding TNP-ATP was eluted from DEAE-Sephadex column in amount of 15 % from the total soluble protein in crude extract. The fluorescent derivative of ATP, 2′(3′)-O-(2,4,6-trinitrophenyl)adenosine-5′-triphosphate (TNP-ATP), was used as a synthetic analog of the substrate for the monitoring and quantitative analysis of the functional activity of SPS. The non-linear regression analysis of the saturation curve of TNP-ATP binding to D197 SPS with GraphPad Prism software fits to a model with 2 distinct binding sites with KDs different in order. The SPS existence in a form of tetramer in given reaction conditions, in accordance with the concentration stoichiometry of 4 moles of TNP-ATP to 1 mole of recombinant protein, is being discussed. The tetramer structure was predicted with molecular modelling software YASARA and modelled in vacuum using steepest descent minimization energy method. We hypothesize here the recombinant SPS exists as a dimer in solution with two active sites capable of ATP binding in each subunit.
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9

Síťař, Vladislav, and Jan Veleba. "Modelling of Metal Oxide Surge Arresters in Simulation Software DYNAST." TRANSACTIONS ON ELECTRICAL ENGINEERING 6, no. 1 (2020): 21–27. http://dx.doi.org/10.14311/tee.2017.1.021.

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This paper describes the possibilities for mathematical modelling of gap-less surge arresters in simulation software DYNAST. This tool does not belong to standard modelling softwares in the field of electric power engineering. However, it may provide some key advantages when compared to more frequently used softwares such as EMTP-ATP and MATLAB-Simulink. Description of the metal oxide varistor modelling at temporary and switching overvoltages, fast-front states, and lightning strokes is presented. More information about the defined internal structure of surge arrester models and ways for implementing respective V-I characteristics are provided. To verify the correct behaviour of the models, both slow and fast overvoltage scenarios are simulated and evaluated.
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10

Wirasari, Riza Ria, Surya Hardi, Rohana Rohana, and Muchsin Harahap. "ANALISA SAMBARAN PETIR TERHADAP SISTEM PROTEKSI TOWER TELEKOMUNIKASI MENGGUNAKAN SIMULASI SOFTWARE ATP DRAW." Rang Teknik Journal 5, no. 2 (2022): 373–78. http://dx.doi.org/10.31869/rtj.v5i2.3416.

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The increase in the telecommunications network was accompanied by the addition of the number of BTS (Base Transceiver Station) in various regions. The BTS (Base Transceiver Station) tower is built with a minimum height of 25-100 meters. BTS towers are equipped with external and internal grounding protection systems that are designed and installed in accordance with SNI. The protection system is a unified protection system for towers and telecommunications equipment from lightning strikes. Lightning strikes occur randomly which cannot be ascertained and their occurrence is controlled and lightning strikes also cause damage to the object that is struck. ATP Draw is a graphical program from the Electromagnetic Transient Program (EMTP) for Windows. Software Alternating Transient Program (ATP Draw) is used for digital simulation of impulse waves. In this software a lightning protection system is modeled in the form of an electrical circuit, and a lightning impulse waveform against a lightning protection system circuit. analyzed the lightning protection system on the BTS tower by performing simulations using ATP Draw software with a power line model with Standard IEC 1.2 x 50 s showing the simulation results of a lightning surge current of 30389 A. for a lightning surge input current of 80 kA, 36088 A for a lightning current input lightning surge of 95 kA, and 37987 A for lightning surge input current of 100 kA. For modeling the standard CIGRE 3.3x77.5μs power line, the simulation results for a lightning surge current of 40644 A for a lightning surge input current of 80 kA, 48264 A for a lightning surge input current of 95 kA, and 50805 A for a lightning surge input current of 100 kA.
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11

Sarajcev, Petar, Slavko Vujevic, and Dino Lovric. "Interfacing harmonic electromagnetic models of grounding systems with the EMTP-ATP software package." Renewable Energy 68 (August 2014): 163–70. http://dx.doi.org/10.1016/j.renene.2014.02.017.

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12

Moura, Adriano Aron Freitas de. "Modelagem para Simulação Dinâmica do DFIG no ATP-EMTP." Revista Eletrônica de Engenharia Elétrica e Engenharia Mecânica 6, no. 2 (2024): 31–42. https://doi.org/10.21708/issn27635325.v6n2.a12936.2024.

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O gerador de indução duplamente alimentado (DFIG) possibilita um controle das potências ativa, reativa e fator de potência do estator da máquina. A principal contribuição do presente trabalho está em analisar matematicamente o DFIG através de modelos que reflitam os mesmos cálculos realizados pelo software ATP-EMTP em regime dinâmico, conhecendo o comportamento transitório das grandezas elétricas em vários pontos do DFIG e posteriormente comparando os resultados das simulações obtidos com os modelos matemáticos desenvolvidos. Realizaram-se simulações computacionais para obter a operação do DFIG, e por fim, foi realizada uma análise dos efeitos que produzem cada tipo de operação da máquina, analisando valores de correntes em regime dinâmico. Para atingir os objetivos, a modelagem do sistema foi simulada no software ATP-EMTP e comparada com as equações implementadas em MATLAB®. Os resultados obtidos pela simulação validaram a modelagem matemática adotada, comprovando a eficiência do modelo em representar as correntes do estator e do rotor nos eixos d e q obtidas nas simulações. Os resultados obtidos neste trabalho mostraram a funcionalidade do ATP-EMTP para a simulação de um DFIG, tornando possíveis diversos estudos de melhoria no desempenho do sistema através da modelagem matemática desenvolvida.
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13

Akinrinde, Ajibola, Andrew Swanson, and Remy Tiako. "Effect of Ferroresonance on Wind Turbine: Comparison of Atp/Emtp and Matlab/Simulink." Indonesian Journal of Electrical Engineering and Computer Science 14, no. 3 (2019): 1581. http://dx.doi.org/10.11591/ijeecs.v14.i3.pp1581-1594.

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Different developers have produced several software packages as solutions to model electrical power systems for the purpose of carrying out diverse analyses to solve immediate and unforeseen problems in power systems. In this study, ATP/EMTP and Matlab/Simulink packages were compared in regards to their capability to give accurate results, time of simulation and ease of simulation when modeling DFIG wind turbine. Furthermore, ferroresonance caused by one stuck pole during switching operations were analyzed on both software. Characterization of resulting ferroresonance was done using Fast Fourier Transformation (FFT) analysis, phase plane diagram and Poincaré mapping. Chaotic mode ferroresonance was found in both ferroresonance events. However, ATP could only perform FFT analysis while other analyses were performed on Matlab/Simulink. There are differences in the results obtained from the two packages; overvoltage of 4.22 P.U. and 3.77 P.U. was experienced during opening and closing operation on ATP/EMTP model while 6.36 P.U. and 4.63 P.U. respectively was obtained on Matlab. However, ATP is faster in regards to time of simulation with CPU time of 110.58 secs and simulink simulation time was 130.81 secs. Finally, it was easier to carry out the simulation on Simulink.
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14

SUTCLIFFE, GEOFF. "SEMANTIC DERIVATION VERIFICATION: TECHNIQUES AND IMPLEMENTATION." International Journal on Artificial Intelligence Tools 15, no. 06 (2006): 1053–70. http://dx.doi.org/10.1142/s0218213006003119.

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Automated Theorem Proving (ATP) systems are complex pieces of software, and thus may have bugs that make them unsound. In order to guard against unsoundness, the derivations output by an ATP system may be semantically verified by trusted ATP systems that check the required semantic properties of each inference step. Such verification needs to be augmented by structural verification that checks that inferences have been used correctly in the context of the overall derivation. This paper describes techniques for semantic verification of derivations, and reports on their implementation and testing in the GDV verifier.
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15

Xiao, Gang, Quansen Rong, Miaoran Yang, et al. "Research on VFTO Identification of GIS Based on Wavelet Transform and Singular Value Decomposition." Energies 15, no. 9 (2022): 3367. http://dx.doi.org/10.3390/en15093367.

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The accurate identification of Very Fast Transient Overvoltage (VFTO) is the key of overvoltage control in modern smart grids. In order to accurately identify VFTO generated by the operation of a disconnector in Gas Insulated Substation (GIS), a VFTO identification method based on Wavelet Transform (WT) and Singular Value Decomposition (SVD) is proposed. The simulation model of VFTO is established in ATP-EMTP software first, and then wavelet decomposition is used in MATLAB software for VFTO simulation of the waveform from the ATP-EMTP software. Then, the feature matrix is composed of the coefficients of each frequency layer of the wavelet. The SVD is used to decompose the feature matrix, and finally the characteristic parameters of the VFTO are obtained. The simulation results in Matlab software indicate that the characteristic parameters of VFTO have an obvious difference compared with those of power frequency AC voltage, especially in the load-side, which verifies the effectiveness of the VFTO identification method based on WT and SVD proposed in this paper.
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16

Rita, Rauza S., Kevin N. Cuandra, Salsabila P. Khairani, et al. "Bioinformatic investigation of Lytechinus variegatus coelomic fluid peptides as multiple oncogenic proteins inhibitors of colorectal cancer." Journal of Pharmacy & Pharmacognosy Research 13, no. 1 (2025): 341–55. http://dx.doi.org/10.56499/jppres24.2085_13.1.341.

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Context: Colorectal cancer (CRC) remains a significant global health challenge despite advances in treatment modalities. The coelomic fluid of Lytechinus variegatus emerges as a rich source of bioactive peptides with the potential as a new therapeutic anticancer agent. Aims: To analyze the toxicity, allergenicity, and potential of L. variegatus coelomic fluid peptides as multitarget inhibitor agents of CRC cancer cells through an in silico study. Methods: Ten peptides from L. variegatus coelomic fluid were processed using UCSF Chimera software to model the three-dimensional structure. ToxinPred and AllerTop web servers were used to analyze the toxicity and allergenicity of peptides, respectively. The 3D structures of EGFR, AKT1, GSK3B, VEGFR2, and JAK3 were retrieved from the PDBJ database. MOE Software was used to perform molecular docking. Results: Peptide 4 binds to the ATP binding pocket of GSK3B protein with the strongest binding affinity value (-8,68 kcal/mol). The docking results between EGFR and peptides showed that peptide 10 binds to the ATP binding pocket with the lowest binding affinity (-9.52 kcal/mol). Peptide 2 binds to the ATP binding pocket of AKT1 with the lowest binding affinity value (-9.16 kcal/mol). Peptide 3 has the lowest binding affinity value of the JAK3 ATP binding pocket (-8,67 kcal/mol). Peptide 7 binds to the ATP binding pocket of VEGFR2 with the strongest binding affinity (-9,67 kcal/mol). Conclusions: The L. variegatus peptides have the potential as multitarget anti-CRC agents by inhibiting the activity of GSK3B, EGFR, AKT1, JAK3, and VEGFR2 proteins through the ATP competitive inhibitor action based on in silico study.
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17

Intan Sustiawan, Sahabuddin Hay, Mustamin, et al. "Analisis Unjuk Kerja Peralatan Gardu Induk 70 KV Nii Tanasa Menggunakan Software ATP Draw." Jurnal Fokus Elektroda : Energi Listrik, Telekomunikasi, Komputer, Elektronika dan Kendali) 9, no. 4 (2024): 248–54. https://doi.org/10.33772/jfe.v9i4.264.

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Indonesia merupakan daerah yang terletak di garis Katulistiwa dengan iklim tropis dan kelembaban yang tinggi, sehingga menyebabkan potensi surja petir di Indonesia jauh lebih besar dibandingkan dengan negara lainnya. surja petir dapat menyebabkan kerusakan terhadap sistem dan peralatan listrik yang dapat berdampak terhadap kualitas dan keandalan penyaluran sistem tenaga listrik. Untuk meningkatkan kinerja proteksi surja petir dan mengurangi jumlah kegagalan dalam jalur transmisi sehingga pada Gardu Induk terdapat beberapa alat proteksi, salah satunya yaitu Arrester. Penelitian ini bertujuan untuk menganalisis kinerja sistem proteksi pada gardu induk 70 kV Nii Tanasa terhadap tegangan lebih akibat sambaran petir. Simulasi dilakukan menggunakan software ATP Draw, dengan pemodelan gardu induk dan beberapa skenario pemasangan arrester: tanpa menggunakan arrester, arrester di pintu masuk gardu, arrester dekat transformator, serta kombinasi arrester di kedua lokasi. Hasil simulasi menunjukkan bahwa pemasangan arrester secara bersamaan di pintu masuk gardu dan dekat transformator memberikan perlindungan optimal, mampu mereduksi tegangan lebih pada arus petir 3 kA dan 5 kA sehingga peralatan berada dalam batas aman. Namun, pada arus petir lebih tinggi, yaitu 10 kA dan 20 kA, arrester kurang mampu menahan seluruh lonjakan tegangan, sehingga potensi risiko kerusakan tetap ada. Penelitian ini menegaskan pentingnya strategi penempatan arrester untuk meningkatkan keandalan dan keamanan operasi gardu induk dalam menghadapi gangguan tegangan lebih akibat petir.
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Yang, Zhe, Juan Wang, Jia Yang, Zhi Qi, and Jiahao He. "Recognizing Proteins with Binding Function in Elymus nutans Based on Machine Learning Methods." Combinatorial Chemistry & High Throughput Screening 23, no. 6 (2020): 554–62. http://dx.doi.org/10.2174/1386207323666200330120154.

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Background: We research the binding function proteins in Elymus nutans. Recognition for proteins is essential for study of biology. Machine learning methods have been widely used for the prediction of proteins. Methods: We used BLAST software for the function annotations of Elymus nutans. Besides, we used machine learning methods to recognize proteins which are not annotated by the software. In the process, we focused on identifying the proteins with binding functions. In our research, features are extracted by four algorithms, and then selected by mutual information estimator. Here three classifiers are constructed based on K-nearest neighbour algorithm and gradient boosting algorithm. Results and Conclusion: Experimental results show that there are 848 proteins with ATP binding function, 113 proteins with heme binding function, 315 proteins with zinc-ion binding function, 135 proteins with GTP binding function and 21 proteins with ADP binding function. Furthermore, we have successfully predicted the functions of 10 special protein sequences whose function annotations cannot be obtained by making sequence alignment with seven famous protein databases. Among them, seven sequences have ATP binding functions, one sequence has heme binding function, one sequence has zinc-ion binding function and the other one has GTP binding function.
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19

Stojković, Saša, Miroslav Bjekić, and ŽArko Janda. "Educational simulation model for studying the impact of distributed generation on distribution networks using ATP-EMTP software." International Journal of Electrical Engineering & Education 51, no. 4 (2014): 292–305. http://dx.doi.org/10.7227/ijeee.0002.

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This work presents the use of the modern software tool Alternative Transients Program (ATP) in the teaching of power engineering, within the course Computer Aided Engineering. A simulation model is presented through which it is possible to analyse the effects of distributed generators (DG) on the operation of a distribution network in both a steady and a transient state, with the objective of fulfilling the conditions for connection. This problem was selected not only because it allows students to gain proper insight into the phenomena within a distribution network with a connected distributed generator, but also because it has been shown that the problem of educating engineers is often a constraining factor for implementing distributed generation (DG). It is shown that by using the software tool ATP-EMTP, very complex phenomena in large networks can be studied without great difficulty or the need for analytical methods. The problem-based learning (PBL) method was applied.
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20

Pinton, Mariangela, and Alvair Silveira Torres Jr. "THE AGILE TRANSITION PROCESS OF ORGANIZATIONS IN SOFTWARE DEVELOPMENT PROJECT MANAGEMENT." REPAE - Revista de Ensino e Pesquisa em Administração e Engenharia 9, no. 3 (2023): 16–37. http://dx.doi.org/10.51923/repae.v9i3.302.

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Organizations which use Traditional Project Management Models face the great challenge to transform their processes and their culture. In this context, this research aimed to develop a set of recommendations to be adopted by the organizations to facilitate the transition from the traditional to the agile model in software development project management. Exploratory qualitative research was carried out in two steps: a Systematic Literature Review and semi-structured interviews. The conclusion was that the ATP causes great impact on people and the main practices should aim to reduce team resistance. In addition, it should be an initiative of the whole organization.
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21

Gulov, A. M., and A. V. Kolychev. "Study of influence of corona effect on 110 kV overhead line, lightning protection cable on energy characteristics of linear surge arresters during lightning overvoltages." Vestnik IGEU, no. 1 (February 28, 2024): 60–65. http://dx.doi.org/10.17588/2072-2672.2024.1.060-065.

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The corona effect has a significant impact on calculations of lightning protection of the high-voltage overhead transmission line. The corona effect in the calculation of the transient process during a lightning overvoltages is often neglected due to the complexity of modeling the corona effect. The issue of the corona effect influence on the operation of non-linear surge suppressors installed on overhead lines hasn’t been sufficiently studied. The aim of the research is to evaluate the energy characteristics of linear surge arresters considering the corona effect on the overhead line. Simulation of the transient process on the overhead line during lightning overvoltages is carried out in the EMTP-ATP software. There is no corona model among the basic models in EMTP-ATP software. Thus, the corona model on overhead line wires using dynamic capacitances is under consideration. A model of corona on overhead line wires in EMTP-ATP is developed. Calculations of energy characteristics of linear surge arresters on an overhead line model considering the corona and without corona effect are carried out. The comparison of the obtained energy characteristics is carried out. The corona has a significant effect on the energy absorbed by the linear surge arresters during lightning strikes to the ground-wire if the front time of the lightning current impulse has a value near 1 s. When lightning strikes to the phase wire, the energy absorbed by the linear surge arresters is so great that the influence of the corona effect is insignificant. The corona model used in calculations in EMTP-ATP software has several limitations. Therefore, in future research it’s advisable to improve the model and simplify it, when calculating lightning protection of overhead lines.
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Abbaszadeh, Amir, Mehrdad Abedi, and Ali Doustmohammadi. "Comparison of transformer modeling on riser pole arresters behavior during switching transients." Archives of Electrical Engineering 66, no. 4 (2017): 717–30. http://dx.doi.org/10.1515/aee-2017-0054.

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Abstract Arresters are widely used in power systems to protect other equipment against overvoltages. However, in some conditions, they can’t operate successfully. One of the disturbances leading to the failure of the riser pole arresters is the ferroresonance overvoltages. In this paper, at first the influence of different transformer simulation models of ATP software on the occurrence of ferroresonance is studied and then the effect of ferroresonance on the riser pole arrester has been scrutinized through the thermal and electrical performance of the arrester in an underground distribution system. The results show that the arrester temperature rises due to energy dissipation in a ferroresonance circumstance, which indeed may result into the explosion of the arrester. Also, applying different models of the transformer in the ATP software and comparing the results, it is shown that the available models do not show the same effect on the arrester.
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Nachtigall, Petr, and Erik Tischer. "Simulation assessment of the headway under the ETCS L3." Acta Polytechnica CTU Proceedings 43 (November 22, 2023): 81–85. http://dx.doi.org/10.14311/app.2023.43.0081.

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This paper deals with a simulation assessment of the impact of the introduction of ETCS L2 and L3 on the capacity of railway lines. The simulation itself is carried out in the OpenTrack simulation software, especially in the tool headway calculator. For this research, an infrastructure model has been built, which represents a typical layout of lines and stations in the Czech Republic. By successive modifications of the model, the significance of the impact of the implementation of ATP systems on the capacity of lines can be simulated. In the paper, the influence of the implementation of different application levels of ATP systems on the capacity of railway lines is evaluated.
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Nicollin, Xavier, Joseph Sifakis, and Sergio Yovine. "From ATP to timed graphs and hybrid systems." Acta Informatica 30, no. 2 (1993): 181–202. http://dx.doi.org/10.1007/bf01178579.

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Lwin, Wint, Ken Park, Matt Wauson, Qin Gao, David Perkins, and Ajai Khanna. "Applying systems biology to develop T cell tolerance: Jurkat cell responses to knockdown hub genes using siRNA in-vitro transfection (169.47)." Journal of Immunology 186, no. 1_Supplement (2011): 169.47. http://dx.doi.org/10.4049/jimmunol.186.supp.169.47.

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Abstract Introduction: Systems biology is increasingly gaining importance in studying complex genome wise associations and will, in future, integrate into personalized medicine. Aim: To study the effect of T cell lipotransfection by certain hub genes and evaluate their role in inducing T cell anergy. Methods: Using publically available gene-gene interactions, we constructed a network using an open bioinformatics software platform for visualizing molecular interaction networks to identify the following upregulated hub genes: ATP5C1, IL6ST, PRKCZ, MYC, FOS, JUN and MAPK1. We hypothesized that suppression of hub genes in the gene network would result in significant phenotypic effects on T cells resulting in T cell hyporesponsiveness and examined this in-vitro. Jurkat and HeLa cells were transfected with siRNA for the selected hub genes. Cell proliferation was measured using ATP luminescence and BRDU labeling. Results: We found a significant decrease in ATP production by Jurkat cells (P<0.05) when the hub genes ATP5C1 and PRKCZ were knocked down using siRNA transfection. No difference in ATP production was observed in siRNA transfected HELA cells. However, these cells showed a significant (P<0.05) decrease in cell proliferation when the genes MAPK1, IL6ST, ATP5C1, JUN and FOS were knocked down using siRNA. This experiment provides proof of principle of applying a systems biology approach in identifying hub genes for targeted therapeutics in transplant immunology.
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Shue Liu, and Dashe Li. "Research of ATP System in the Atmospheric Turbulence at Sea." International Journal of Digital Content Technology and its Applications 5, no. 5 (2011): 95–100. http://dx.doi.org/10.4156/jdcta.vol5.issue5.10.

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Li, Xiao Gang, Li Xue Li, Yi Hui Zheng, Xin Wang, Jian You Yu, and Jing Bo Yang. "Study on the Identification of Lightning Over-Voltage Based on ATP-EMTP." Applied Mechanics and Materials 672-674 (October 2014): 799–802. http://dx.doi.org/10.4028/www.scientific.net/amm.672-674.799.

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Lightning overvoltage often leads to transmission lines trip, which is the weak link of power system. In this paper, 110-kV transmission line model is studied on the basis of the EMTP software. Several simulation models are established for back flashover lightning, induced lightning, shield failure. The transient process of lightning stroke is studied. According to the contrast of simulation results of three kinds of lightning, a set of discriminant basis to distinguish lightning on transmission line is put forward.
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DENNEY, EWEN, BERND FISCHER, and JOHANN SCHUMANN. "AN EMPIRICAL EVALUATION OF AUTOMATED THEOREM PROVERS IN SOFTWARE CERTIFICATION." International Journal on Artificial Intelligence Tools 15, no. 01 (2006): 81–107. http://dx.doi.org/10.1142/s0218213006002576.

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We describe a system for the automated certification of safety properties of NASA software. The system uses Hoare-style program verification technology to generate proof obligations which are then processed by an automated first-order theorem prover (ATP). We discuss the unique requirements this application places on the ATPs, focusing on automation, proof checking, traceability, and usability, and describe the resulting system architecture, including a certification browser that maintains and displays links between obligations and source code locations. For full automation, the obligations must be aggressively preprocessed and simplified, and we demonstrate how the individual simplification stages, which are implemented by rewriting, influence the ability of the ATPs to solve the proof tasks. Our results are based on 13 comprehensive certification experiments that lead to 366 top-level safety obligations and ultimately to more than 25,000 proof tasks which have been used to determine the suitability of the high-performance provers DCTP, E-Setheo, E, Gandalf, Otter, Setheo, Spass, and Vampire, and our associated infrastructure. The proofs found by Otter have been checked by Ivy.
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Vaca González, Juan Jairo, Claudia Marcela Ramírez Espinosa, Ingrid Carolina Guayan Ardila, Julieth Yadira Serrano Riaño, and Diana Paola Torres Gil. "Monitoring the effectiveness of surgical handwashing in healthcare workers of a fourth level operating room using bioluminescence assays." Ingeniería Solidaria 18, no. 3 (2022): 1–24. http://dx.doi.org/10.16925/2357-6014.2022.03.08.

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Aims: To assesses the effectiveness of surgical handwashing (S-HW) in healthcare workers (HCWs) in terms of organic material and bacteria elimination by means of bioluminescence assays.
 Methods: 62-HCWs were subjected to bioluminescence analyses to determine adenosine triphosphate (ATP) and colony forming units (CFU) of Enterobacteriaceae (EB) and E. coli before and after S-HW. A checklist to evaluate adherence to hand hygiene (HH) protocol was implemented.
 Results: ATP before HH (510.9/RLU) was reduced after S-HW (54.6/RLU), evidencing a significant decrease (p=0.001). Regarding the bacteria, 26.6/CFU and 4/CFU for EB and E. coli were reported before S-HW, respectively. After S-HW, CFU decreased for EB (21.8/CFU) and E. coli (3.5/CFU) without showing a significant reduction (p=0.679). Low ATP did not evidence a direct relation with EB (p=0.082) and E. coli (p=0.680) reduction. Surgical instrument professionals (p=0.001), general surgeons (p=0.001), residents (p=0.017), orthopedists (p=0.029) and otolaryngologists (p=0.029) evidenced a reduction in ATP after S-HW. Factors such as S-HW direction, surgical soap, moments and time of S-HW implemented showed a statistically significant difference in reduction of ATP, but not in CFU.
 Conclusion: Although there was a reduction in elimination of ATP, there was no evidence of a decrease in bacteria. This finding not only allowed to identify potential errors in S-HW processes, but also permitted to generate strategies to improve HH to prevent healthcare-associated infections.
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Moore, J. Strother. "Introduction to the OBDD algorithm for the ATP community." Journal of Automated Reasoning 12, no. 1 (1994): 33–45. http://dx.doi.org/10.1007/bf00881842.

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Halim, M. I. A. M., N. K. H. Rohani, N. Rosle, A. S. C. Rosmi, C. Yii, and W. A. Mustafa. "Location Technique based on Multiple Partial Discharge Signal in 11kV Underground Power Cable using EMTP-ATP Software." Journal of Physics: Conference Series 1793, no. 1 (2021): 012071. http://dx.doi.org/10.1088/1742-6596/1793/1/012071.

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Safitri, Novita, and Wahyu Anggraini. "Trust on Sharia M-Banking: Evidance on Milenials Generations." Journal of Islamic Economic Scholar 2, no. 1 (2021): 10. http://dx.doi.org/10.14421/jies.2021.2.1.1429.

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This study aims to examine the trust of millennial generation in the role of sharia mobile banking in the ease of solving their financial problems. The increased use of smartphones has made the banking industry provide mobile banking services to facilitate and increase customer productivity. The level of trust in sharia mobile banking is measured using the Technology Acceptance Model (TAM). Based on TAM, trust is determined by Perceived Easy of Use (PEoU), Perceived Usefulness (PU), Attitude to Product (ATP), and Intention to Use (ITU). This study uses an independent survey, with a total sample of 330 sharia mobile banking users spread throughout Indonesia. Data analysis techniques used in this study used SB-SEM (Covariance Based-Structural Equation Modeling) with AMOS software. The results showed that PEoU had a positive effect on PU, PEoU had a positive effect on ATP, PU had a positive effect on ATP, ATP had a positive effect on ITU, and ITU had a positive effect on Trust. Overall millennial generation has a high level of trust in sharia mobile banking, because sharia mobile banking is easy to use and makes it easy to solve their financial problems.
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Safitri, Novita, and Wahyu Anggraini. "Trust on Sharia M-Banking: Evidance on Milenials Generations." Journal of Islamic Economic Scholar 2, no. 1 (2021): 10. http://dx.doi.org/10.14421/jies.2021.2.1.10-23.

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This study aims to examine the trust of millennial generation in the role of sharia mobile banking in the ease of solving their financial problems. The increased use of smartphones has made the banking industry provide mobile banking services to facilitate and increase customer productivity. The level of trust in sharia mobile banking is measured using the Technology Acceptance Model (TAM). Based on TAM, trust is determined by Perceived Easy of Use (PEoU), Perceived Usefulness (PU), Attitude to Product (ATP), and Intention to Use (ITU). This study uses an independent survey, with a total sample of 330 sharia mobile banking users spread throughout Indonesia. Data analysis techniques used in this study used SB-SEM (Covariance Based-Structural Equation Modeling) with AMOS software. The results showed that PEoU had a positive effect on PU, PEoU had a positive effect on ATP, PU had a positive effect on ATP, ATP had a positive effect on ITU, and ITU had a positive effect on Trust. Overall millennial generation has a high level of trust in sharia mobile banking, because sharia mobile banking is easy to use and makes it easy to solve their financial problems.
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Ardo Cahya, Pratama, Nadaa Karuniasari, Agnia Fadillah Rahmadini, et al. "Phylogenetic Study of Several Parasitic Plant Species Based on The atp-1 Gene Sequence." JSMARTech 5, no. 2 (2024): 57–63. http://dx.doi.org/10.21776/ub.jsmartech.2024.005.02.57.

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The distinction between parasitic and non-parasitic plants can be determined by analyzing the atp-1 gene, which plays a vital role in respiration and is known for its high mutation rate. This study analyzed the kinship of parasitic plant subclass species through the construction of a phylogenetic tree based on atp-1 gene sequences. The atp-1 gene sequences of parasitic and non-parasitic plants with a total of 29 species were obtained from NCBI. The sequences were then aligned with ClustalW and analyzed for mutation patterns. Sequences that have been aligned, phylogenetic trees were made with MEGA11 software with the Maximum Likelihood method and analyzed using the iTOL website. The sequences were analyzed for similarity and kinship with Matrix Coefficient and Haplotype Construction. The atp-1 gene proved that parasitic plants (hemiparasites) are furthermore related to non-parasitic plants compared to holoparasite parasitic plants. Besides that, the kinship of parasitic plants can be analyzed by several methods, namely matrix coefficient to measure similarity, DnaSP to analyzing haplotype, and haplotype network to find out detailed information on mutations that occur. Matrix coefficients can also be used to measure specific similarities between species. It was found that the same subclass had high similarities, for example the species Santalum album and Heisteria parvifolia with a genetic distance value of 0.00574. Meanwhile, different subclasses have low similarity, such as Cassytha filiformis and Ombrophytum with a genetic distance value of 0.07871. This study shows that the atp-1 gene is effective in analyzing the kinship between parasitic and non-parasitic plants. Hemiparasites are genetically closer to non-parasitic plants than holoparasites, with higher genetic similarity within the same subclass.
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Al-Tak, Mazyed A., Mohd Fadzil Ain, Omar Sh. Al-Yozbaky, and Mohamad Kamarol Mohd Jamil. "Impact of grading capacitor on transient recovery voltage due to shunt reactor de-energization for different values of current chopping." International Journal of Power Electronics and Drive Systems (IJPEDS) 15, no. 2 (2024): 1300–1307. https://doi.org/10.11591/ijpeds.v15.i2.pp1300-1307.

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This paper investigates the impact of grading capacitors on transient recovery voltage (TRV) during shunt reactor switching in high voltage systems, considering different levels of current chopping. Shunt reactor de-energization can result in voltage surges and instability due to current chopping effects. The study utilizes simulation models using ATP-Draw software to assess the effectiveness of grading capacitors in mitigating TRV under various operating conditions as well as of using a proposed method to mitigate the excessive TRV across the circuit breaker. The findings provide valuable insights into managing TRV during shunt reactor switching, enhancing power system stability and reliability. The results obtained showed that the TRV across the circuit breaker decreased by 61.5% by using circuit modification as well as adding a grading capacitor.
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Linn, Kyaw Zaw, Ong Chong Hui Clara, Sharifah Farhanah, et al. "SG-APSIC1091: Assessment of compliance to cleaning of computers by healthcare workers (HCWs) using adenosine triphosphate (ATP) measurement." Antimicrobial Stewardship & Healthcare Epidemiology 3, S1 (2023): s12—s13. http://dx.doi.org/10.1017/ash.2023.38.

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Objectives: HCWs are recommended to wipe the computers with alcohol wipes before clinical use. Compliance assessment by direct observation is resource intensive. We used ATP measurement as a surrogate to assess the compliance to preutilization cleaning of computers. Methods: We conducted a pilot study to determine the median relative light unit (RLU) value reflective of preutilization cleaning of the computers. We identified values of <250, 250–500, and >500 RLU to reflect cleaned, probably cleaned, and not cleaned computers, respectively. Subsequently, we conducted a cross-sectional study of the computers in the inpatient wards in Tan Tock Seng Hospital and National Centre for Infectious Diseases. Using 3M Clean-Trace ATP swabs, we tested 5 computers in each ward: 2 computers on wheels, 2 from the nursing station, and 1 at the patients’ room entrance. All analyses were conducted using STATA version 15 software. Results: Between October 4 and 10, 2021, we collected 219 samples from 219 computers. Among them, 44 (20.1%) were cleaned, 49 (22.4%) were probably cleaned, and 126 (57.5%) computers were not cleaned. Higher compliance to computer cleaning was observed in COVID-19 wards [85 ATP samples; cleaned, 37 (43.5%); probably cleaned, 26 (30.6%); not cleaned, 22 (25.9%)] compared with non–COVID-19 wards [134 ATP samples; cleaned, 7 (5.2%); probably cleaned, 23 (17.2%); not cleaned, 104 (77.6%)] (P < .01). No significant difference was observed in compliance with cleaning computers between the ICU [30 ATP samples; cleaned, 7 (23.3%); probably cleaned, 4 (13.3%); not cleaned, 19 (63.3%)] and general wards [189 ATP samples; cleaned, 37 (19.6%); probably cleaned, 45 (23.8%); not cleaned, 107 (56.6%)] (P = .47). Conclusions: ATP swab tests can be used as a surrogate marker to assess compliance to pre-utilization cleaning of computers. Enhanced awareness of environmental hygiene may explain the higher compliance to computer cleaning observed in COVID-19 wards.
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Richey, Kendall D., Culler Hannah, Matt J. Hersom, William C. Bridges, and Celina M. Checura. "PSIII-4 Effect of Photobiomodulation Treatment on Atp Concentrations in Bovine Oocytes During Maturation." Journal of Animal Science 101, Supplement_3 (2023): 389–90. http://dx.doi.org/10.1093/jas/skad281.461.

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Abstract Oocyte cytoplasmic maturation is critical in determining the success of subsequent embryo development. It has been proposed that light in the red-to-near infrared optical region (~600–1000 nm) enhances cellular metabolic activity through activation of the mitochondrial respiratory chain, increasing intracellular ATP concentrations, and has the potential to modify the oocyte metabolome. Previous research indicated a greater cleavage rate and similar blastocyst rates for bovine oocytes treated with photobiomodulation at hours 16 and 20 from the start of maturation compared with control. For the present study, two separate experiments were conducted to determine ATP concentration in oocytes during maturation after photobiomodulation treatment. A standardized in vitro maturation (IVM) protocol and commercial media (IVF Bioscience) were used. Briefly, bovine ovaries were obtained at a local slaughterhouse, cumulus oocyte complexes (COCs) were collected by aspiration of small (2 to 6 mm) follicles. For experiment 1, compact COCs were cultured in in vitro maturation media (n = 30/well) and treated with no light (control); light (660-665nm) for 10 minutes at hour 16 from start of maturation (L-16) and light for 10 minutes at hour 20 from the start of maturation (L-20). At hour 24 of in vitro maturation, COCs were vortexed to remove cumulus, stained with BioTracker ATP-Red Live Cell Dye (Sigma-Aldrich SCT045), imaged with Cytation-1 (Agilent Technologies Inc.) in 6 replicates. For experiment 2, COCs were cultured in in vitro maturation media (n = 40/well) and treated with no light (control) and light (660-665nm) for 10 minutes at hour 16 from start of maturation (L-16). At hours 18, 20, 22 and 24 of in vitro maturation, COCs were vortexed to remove cumulus, stained with BioTracker ATP-Red Live Cell Dye, and imaged with Cytation-1 in 4 replicates. For experiment 1, one-way ANOVA and Student’s T-Test were performed (JMP software 16.0); in experiment 2, each well was considered as an experimental unit in a model of repeated measures, main effects of time and treatment, blocked by replicate (Mixed procedure, SAS Institute Inc.). In experiment 1, there was a significant (P < 0.05) effect of treatment; ATP concentrations were greater in L-16 than control, and L-20 was intermediate. ATP concentrations were 19,579.3a ± 596.5, 21,652.0b ± 602.7 and 19,710.9ab ± 570.6 relative fluorescence units (RFU) for control, L-16, and L-20 respectively. In experiment 2, there was a significant (P < 0.05) effect of treatment and no significant effect of time. Overall ATP concentrations were 25,668 ± 894.6 and 28,332 ± 894.6 RFU for control and L-16 respectively. In conclusion, photobiomodulation treatment with LED 660-665nm for 10 minutes at hour 16 from start of oocyte maturation increases intracellular ATP concentrations from hour 18 to 24 of maturation.
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Sundaresan, K., V. Anantharaman, Hung-Yun Hsieh, and A. R. Sivakumar. "ATP: a reliable transport protocol for ad hoc networks." IEEE Transactions on Mobile Computing 4, no. 6 (2005): 588–603. http://dx.doi.org/10.1109/tmc.2005.81.

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39

Widyananda, Muhammad Hermawan, Setyaki Kevin Pratama, Rizky Senna Samoedra, et al. "Molecular docking study of sea urchin (Arbacia lixula) peptides as multi-target inhibitor for non-small cell lung cancer (NSCLC) associated proteins." Journal of Pharmacy & Pharmacognosy Research 9, no. 4 (2021): 484–96. http://dx.doi.org/10.56499/jppres21.1047_9.4.484.

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Context: Lung cancer is a type of cancer that causes the most deaths worldwide. The most common type of lung cancer is non-small cell lung cancer (NSCLC). Sea urchin (Arbacia lixula) has high potential as an anti-NSCLC agent. Aims: To analyze the anticancer activity of peptides from A. lixula coelomic fluid in inhibiting the activity of NSCLC-related proteins. Methods: Peptide modeling was performed using the PEP-FOLD3 web server. Proteins that have a crucial role in NSCLC progression were determined using KEGG pathway database. 3D protein structures such as EGFR, PI3K, BRAF V600E, and JAK3 were taken from the RCSB PDB database. Docking was performed using Autodock Vina software. Docking results analysis was carried out using Discovery Studio 2019 software. Results: Some peptides bind to the active sites with low binding affinity. Peptide 10 binds to the active site of the EGFR with a binding affinity of -9 kcal/mol. Peptide 5 binds to the active sites of PI3K and BRAF V600E with binding affinity of -8.2 and -8.1 kcal/mol, respectively. Peptide 11 binds to the active site of JAK3 with a binding affinity of -8.1 kcal/mol. All of these peptides have lower binding affinity than ATP as the native ligand. Besides, these peptides also produce more hydrogen bonds than ATP, so they are predicted to be more stable. Conclusions: Peptides 10, 5, and 11 have high potential as anti-NSCLC agents because they can inhibit the activity of proteins that play an essential role in the growth of NSCLC, namely EGFR, PI3K, BRAF V600E, and JAK3 through the competitive ATP inhibitor mechanism.
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Nazerian, Vahdat, Mohammad Esmail Zakerifar, Mahmoud Zadehbagheri, Mohammad Javad Kiani, and Tole Sutikno. "Comparative detection and fault location in underground cables using Fourier and modal transforms." International Journal of Electrical and Computer Engineering (IJECE) 12, no. 6 (2022): 5821. http://dx.doi.org/10.11591/ijece.v12i6.pp5821-5839.

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<span>In this research, we create a single-phase to ground synthetic fault by the simulation of a three-phase cable system and identify the location using mathematical techniques of Fourier and modal transforms. Current and voltage signals are measured and analyzed for fault location by the reflection of the waves between the measured point and the fault location. By simulating the network and line modeling using alternative transient programs (ATP) and MATLAB software, two single-phase to ground faults are generated at different points of the line at times of 0.3 and 0.305 s. First, the fault waveforms are displayed in the ATP software, and then this waveform is transmitted to MATLAB and presented along with its phasor view over time. In addition to the waveforms, the detection and fault location indicators are presented in different states of fault. Fault resistances of 1, 100, and 1,000 ohms are considered for fault creation and modeling with low arch strength. The results show that the proposed method has an average fault of less than 0.25% to determine the fault location, which is perfectly correct. It is varied due to changing the conditions of time, resistance, location, and type of error but does not exceed the above value.</span>
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Vahdat, Nazerian, Esmail Zakerifar Mohammad, Esmail Zakerifar Mohammad, Javad Kiani Mohammad, and Sutikno Tole. "Comparative detection and fault location in underground cables using Fourier and modal transforms." International Journal of Electrical and Computer Engineering (IJECE) 12, no. 6 (2022): 5821–39. https://doi.org/10.11591/ijece.v12i6.pp5821-5839.

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In this research, we create a single-phase to ground synthetic fault by the simulation of a three-phase cable system and identify the location using mathematical techniques of Fourier and modal transforms. Current and voltage signals are measured and analyzed for fault location by the reflection of the waves between the measured point and the fault location. By simulating the network and line modeling using alternative transient programs (ATP) and MATLAB software, two single-phase to ground faults are generated at different points of the line at times of 0.3 and 0.305 s. First, the fault waveforms are displayed in the ATP software, and then this waveform is transmitted to MATLAB and presented along with its phasor view over time. In addition to the waveforms, the detection and fault location indicators are presented in different states of fault. Fault resistances of 1, 100, and 1,000 ohms are considered for fault creation and modeling with low arch strength. The results show that the proposed method has an average fault of less than 0.25% to determine the fault location, which is perfectly correct. It is varied due to changing the conditions of time, resistance, location, and type of error but does not exceed the above value.
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42

Kang, Jun, Shen Jie, Yu Hai Li, Jun Hao Li, and Yan Ming Li. "Influence Factor Study of Oscillating Impulse Voltage Generator." Advanced Materials Research 860-863 (December 2013): 2190–93. http://dx.doi.org/10.4028/www.scientific.net/amr.860-863.2190.

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Abstract. The aperiodic impulse voltage generator is huge and difficult to move in field, thereby limits its application in field significantly. For this problem, the oscillating impulse voltage (OIV) is recommended in standard IEC60060-3. In order to study the influence factor of oscillating impulse voltage generator, the simulation circuit is set up using ATP software. The influence of parameters such as shaping resistors, load capacitance and shaping inductance are study in this paper.
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Agrawal, Aditi, Sanjay Gehlot, Ashok Singhal, and Amandeep . "Effect of clinical rotation on attitude of medical students towards psychiatry and mental patients: a cross-sectional study from Western Rajasthan." International Journal of Research in Medical Sciences 9, no. 10 (2021): 2981. http://dx.doi.org/10.18203/2320-6012.ijrms20213919.

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Background: People with mental illnesses experience extreme stigmatization and discrimination despite their ubiquitous presentation. Studies have reported that these negative stereotypes are shared by health care professionals too. Attitude of undergraduate medical students towards psychiatry is vital as it reflects their willingness to deal with psychiatric and behavioral disorders in general practice.Methods: A descriptive cross-sectional study was conducted in a government medical college in Rajasthan to explore the impact of sociodemographic variables and undergraduate psychiatry training on the attitude of medical students towards mental illness and psychiatry. 105 first year MBBS students and 75 interns participated in the study. Attitude towards mental illness (AMI) scale and attitude towards psychiatry-30 (ATP-30) scale were used to document AMI and ATP respectively. Data collected were analyzed using SPSS statistical software and appropriate tests were used to compare mean scores of both groups.Results: There was no statistically significant difference on AMI and ATP scores between the undergraduate medical students and interns. Females, students belonging to urban setting and more educated families had a favorable attitude towards psychiatric patients. A notable shift in scores on ATP scale towards positive side was reflected between male MBBS students and interns and among students coming from rural background with exposure to medical curriculum.Conclusions: No attitude change was observed in majority of participants indicating need for greater emphasis on mental health and psychiatry.
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Arisanty, Dessy, Kevin N. Cuandra, Andani E. Putra, Rauza S. Rita, Cimi Ilmiawati, and Fika T. Anggraini. "Exploring the potential of Arbacia lixula coelomic fluid peptides as cell cycle and angiogenesis inhibitor for triple-negative breast cancer therapy: In silico study." Journal of Pharmacy & Pharmacognosy Research 13, no. 1 (2025): 242–53. http://dx.doi.org/10.56499/jppres24.1991_13.1.242.

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Context: Triple-negative breast cancer (TNBC) is a breast malignancy with a high degree of heterogeneity. Currently, low treatment efficacy remains a challenge in dealing with TNBC. Arbacia lixula has the potential to become a new therapeutic agent in TNBC. Aims: To analyze the toxicity, allergenicity, and potential of A. lixula coelomic fluid peptides as agents that inhibit cell cycle progression and angiogenesis in TNBC cancer cells in silico. Methods: Eight A. lixula coelomic fluid peptides were modeled with UCSF Chimera software. All peptides were screened using the ToxinPred and AllerTop webserver to predict their toxicity and allergenicity. The 3D structures of GSK3B, CDK2, and VEGFR2 proteins were taken from the PDBJ database. Molecular docking was carried out using the MOE application. Results: Peptides 2, 4, 6, and 7 were non-toxic and non-allergen. Peptide 4 has the strongest binding affinity value for binding the ATP binding pocket proteins GSK3β (-11.57 kcal/mol) and VEGFR2 (-11.18 kcal/mol). Peptide 4 interacts similarly with ATP, as a native ligand, on the amino acid residues of GSK3B and VEGFR2. Peptide 1 has a binding affinity value of -10.16 kcal/mol, much stronger than ATP in the CDK2 protein, and forms the same two interactions as ATP at the amino acid residues Asp86 and Lys129. Conclusions: Peptide 1 and peptide 4 of A. lixula coelomic fluid have great potential as anti-TNBC by inhibiting the activity of proteins that play a crucial role in cell cycle progression and TNBC angiogenesis via an ATP competitive inhibitor mechanism through an in silico approach.
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Михейцева, І. М., Ахмед Амаієд, and Сергій Коломійчук. "Retinal energy state in rats with experimental diabetes and axial myopia." Oftalmologicheskii Zhurnal, no. 4 (September 4, 2023): 61–66. http://dx.doi.org/10.31288/oftalmolzh202346166.

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Background: Elucidating the pathogenesis of diabetic retinopathy (DR) for further development of methods of treatment and prevention of the disease is an important medical and social task for ophthalmologists. The development of DR in the presence of myopia has some special features. In the presence of myopia, the diabetic complications in the retina are less severe than in emmetropia. The mechanisms of this paradoxical impact of eye myopization on the severity of these complications are, however, still unknown. Purpose: To examine the state of retinal energy metabolism based on evaluation of biochemical markers of mitochondrial function (lactate, pyruvate, adenosine triphosphate (ATP) and adenosine diphosphate (ADP) levels and succinate dehydrogenase activity) in rats with streptozotocin (STZ)-induced diabetes that developed in the presence of axial myopia, compared to rats with diabetes alone and those with myopia alone. Material and Methods: High axial myopia was produced in two-week animals by surgically fusing the eyelids of both eyes and maintaining these animals under conditions of reduced illumination for two weeks. A 15 mg/kg intraperitoneal streptozotocin injection for 5 days was used for inducing diabetes mellitus in rats with induced axial myopia and intact rats. Animals in the control group were maintained under conditions of natural illumination. In two months, all rats were euthanized under anesthesia, and their eyes were enucleated. ATP, ADP, lactate, and pyruvate levels were measured in blood and retinal specimens and ATP/ADP ratio and lactate/pyruvate ratio were determined. Succinate dehydrogenase activity was determined in isolated retinal mitochondria. For statistical analysis of biochemical results, Student’s t-test was conducted (Statistica software). Results: Rats with diabetes alone exhibited lower retinal and plasma energy metabolism characteristics (ATP, ADP, and succinate dehydrogenase activity), and developed retinal hypoxia, with retinal lactate and pyruvate levels being 1.838-fold and 1.455-fold higher, respectively, and their ratio, 26.5% higher, compared to controls. In animals with STZ-induced diabetes in the presence of axial hypoxia, retinal lactate and pyruvate levels were 20.2% and 15.5% lower, respectively, and their ratio was lower (36.5 versus 38.7), compared to rats with diabetes alone, indicating lower hypoxia in the setting of eye myopization. In addition, in rats with diabetes in the presence of axial hypoxia, plasma and retinal ATP levels were 21.8% and 21.2% higher, respectively, and retinal succinate dehydrogenase activity, 20.8% higher, compared to rats with diabetes alone. Conclusion: In experimental diabetes, an increase in the axial length of the eye (i.e., eye myopization) is accompanied by activation of energy processes and the development of hypoxia adaptation in retinal cells.
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Bhattarai, S., SC Kohli, and S. Sapkota. "Prevalence of metabolic syndrome in type 2 diabetes mellitus patients using NCEP/ATP III and IDF criteria in Nepal." Nepal Journal of Medical Sciences 1, no. 2 (2012): 79–83. http://dx.doi.org/10.3126/njms.v1i2.6604.

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Background: With increasing trends towards sedentary life style, obesity, diabetes mellitus, hypertension, and dyslipidaemia, the prevalence of metabolic syndrome (MetS) is rising in our country. In view of importance of diagnosis of MetS in day to day medical practice for early institution of life style therapies to reduce the atherosclerotic cardiovascular disease risk in susceptible population like in diabetes mellitus, this study has been undertaken to study the prevalence of metabolic syndrome in Nepalese diabetes by applying National Cholesterol Education Programme/Adult Treatment panel (NCEP/ATP) III and International Diabetes Federation (IDF) criteria. Methods: This is a hospital based cross sectional study conducted in diabetes patients aged between 25-75 years of age presenting to Manipal Teaching Hospital, Pokhara. Different components of MetS were studied in diabetes subjects and prevalence of metabolic syndrome was obtained by applying NCEP/ATP III and IDF criteria respectively. The data were collected as per preformed proforma and results analyzed by SPSS-16 software. Results: The prevalence of metabolic syndrome in diabetes patients as per NCEP/ATP III and IDF criteria were 71% and 82% respectively. A higher number of cases with metabolic syndrome were detected using IDF criteria as opposed to NCEP/ATP III criteria in diabetes patients. Nepalese diabetes subjects showed high prevalence of abdominal obesity followed by hypertension. Conclusions: The results of the present study show high prevalence of Mets in Nepalese diabetes patients and more number of cases can be diagnosed by applying IDF criteria as compared to NCEP/ATP III criteria. DOI: http://dx.doi.org/10.3126/njms.v1i2.6604 Nepal Journal of Medical Sciences. 2012;1(2): 78-83
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Cheng, Hsin Yu, Jo Peng Tsai, and Yung Chou Kao. "The Development of an APT Program Interpreter for 5-Axis Machining." Advanced Materials Research 482-484 (February 2012): 2247–52. http://dx.doi.org/10.4028/www.scientific.net/amr.482-484.2247.

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As there are various machine configuration and frequent changes of cutter orientation in 5-axis machining, the standard NC codes are not inter-exchangeable among machines. This phenomenon induces a lot of cutting difficulties and machining problems such as the inconvenient working process for operators and very low cutting efficiency. At present, some advanced machine controllers already can accept the APT code besides NC code to increase the cutting flexibility. They also offer some advanced machining functions such as tool center point control and spatial compensations of tool, etc. By way of APT interpreting, the common controller can also implement these advanced functions. Besides, CAD/CAM software also supports APT post-processor to generate NC code for different machine configurations. This means the application of ATP program has played an important role in five-axis machining. However, although CAD/CAM software supports the interpretation of APT program as a core key technology of five-axis machining, the manufacturers of controller with advanced functions are unwilling to open their system. Up to now, there has been few related research papers published on this topic. In this paper, we proposed an APT interpretation method for five-axis machining. This method includes seven functional modules and related implementing procedures. A case study has been adopted to demonstrate the feasibility of the proposed method. The research result could be adopted as a reference to develop the value-added technology in 5-axis machine tool application for academy and industry.
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48

Galvan, A., and V. Cooray. "Analysis of lightning-induced voltages in a network of conductors using the ATP-EMTP program." Computer Standards & Interfaces 20, no. 6-7 (1999): 489–90. http://dx.doi.org/10.1016/s0920-5489(99)91118-2.

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49

Mull, Makenzy, Stephen Pratt, Rachel Lee, et al. "Abstract 2425: Mechano-response via ATP alters calcium signaling in breast epithelial cells with oncogenic KRas mutation." Cancer Research 82, no. 12_Supplement (2022): 2425. http://dx.doi.org/10.1158/1538-7445.am2022-2425.

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Abstract The majority of breast cancer patient deaths occur when tumor cells migrate away from the primary tumors and disseminate metastatically. Cancer cells at the invasive front mimic the behaviors of non-tumorigenic epithelial cells at wound edges but show less coordinated migration comparatively. While most wound healing studies use a timeframe of 24-48 hours, our previous studies have shown that ATP released from wounded cells initiates a calcium (Ca2+) signal within seconds that spreads to neighboring cells through activation of the P2Y2 surface receptor. RNAseq data of MCF10A mammary epithelial cells with stepwise mutations of PTEN knockout and KRas activation alone or in combination, demonstrate that P2Y2 is downregulated specifically by active KRas. Fluorescence microscopy was used to measure Ca2+ signaling and mitochondrial membrane potential in parental and mutant MCF10A cells. Change in total fluorescence was measured and compared to baseline using Fluo-4, a Ca2+ fluorescent indicator, and TMRM (tetramethylrhodamine, methyl ester), a fluorescent mitochondrial membrane potential dye on Nikon analysis software. We show that KRas activation disrupts ATP stimulation and Ca2+ signaling. This change was further quantified using a FlexStation III plate reader with Fluo-4 to read specific fluorescent changes in Ca2+ after ATP addition. ATP-stimulated Ca2+ was also disrupted in other breast tumor cell lines harboring Ras activating mutations, MDA-MB-231 and MDA-MB-436, both showing a similar decrease in P2Y2 expression. These data show that ATP stimulation can be used to further understand the differences in Ca2+ signaling and mechanical-response between normal breast epithelial cells and cancer cells. Clarifying these molecular mechanisms could reveal targets for new cancer treatments, especially since 90% of human tumors are epithelial carcinomas. Citation Format: Makenzy Mull, Stephen Pratt, Rachel Lee, Abanoub Gad, Katarina Chang, David Annis, Keyata Thompson, Michele Vitolo, Liron Boyman, Stuart Martin. Mechano-response via ATP alters calcium signaling in breast epithelial cells with oncogenic KRas mutation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2425.
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50

Hongtao, Ren, and Zhang Ying. "Research on identification of cable sheath defects based on current analysis of cable sheath." Journal of Physics: Conference Series 2260, no. 1 (2022): 012061. http://dx.doi.org/10.1088/1742-6596/2260/1/012061.

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Abstract This paper presents a method to detect the different types of defects in cross connected cable sheath in a flat 500kV three leaf high voltage cable system with sheath current as input data. Three different defects are analyzed: the loss of electrical continuity of grounding, the short circuit between metal sheath of cable joint segment and the immersion of junction box. The model of cable system is simulated by theoretical analysis and ATP software. The results obtained by these two methods have achieved good consistency.
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