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Dissertations / Theses on the topic 'ATP'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Sperotto, Rita Leal. "Hidrólise de atp e adp em líquor humano." Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/11088.

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Adenine nucleotides hydrolysis is an important step of the neuromodulation of CNS and some of its breakdown products are able to protect the nervous tissue against brain injuries. The activity of NTPDase (EC 3.6.1.5, apyrase, CD39) was verified in cerebrospinal fluid (CSF) from patients without neural inflammatory process under different conditions and in the presence of several inhibitors. The samples were chose considering the low protein levels, normal glucose levels, low leukocyte count and CSF differential count. We chose use the supernatant 1 (S1) for enzyme assay due to the best enzymat

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2

HATIN, ISABELLE. "L'adenylate translocase : un adp/atp transporteur chez plasmodium falciparum." Paris 7, 1994. http://www.theses.fr/1994PA077245.

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L'adp/atp transporteur catalyse l'echange adp/atp a travers la membrane interne des mitochondries. La proteine fonctionnelle est un dimere de deux sous unites identiques de 30 a 34 kda chaque, codee par le genome nucleaire. Cette proteine appartient a une superfamille de transporteurs mitochondriaux. L'objectif de ce travail etait de montrer la presence d'un gene codant pour un adp atp transporteur chez p. Falciparum. L'utilisation repetee de la pcr, nous a permis d'etablir qu'une sequence nucleotidique chez p. Falciparum code pour un polypeptide de 301 acides amines, homologue aux adt mitocho

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3

Lange, Ulf. "Elektrophysiologische Untersuchungen an rekombinanten kardiovaskulären K ATP -Kanälen Effekte von Nukleotiden, neuartigen K ATP -Kanalöffnern und Blockern /." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11947832.

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4

Kramarova, Tatiana. "Limiting factors in ATP synthesis." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-987.

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5

Harrington, R. A. "Evolution of ATP synthase." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603734.

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The hypothesis of modular evolution of the <i>atp</i> operon is re-evaluated by conducting a phylogenetic analysis of the <i>atp</i> operons and constituent genes of all fully sequenced genomes. Although the original hypothesis of modular evolution cannot be conclusively supported, a number of novel observations are made. Foremost is that the <i>atp</i> operon is a mosaic operon, a result of extensive horizontal transfer. In addition, two independent duplication events are proposed for subunits b/b’ of the enzyme, the transmembrane subunits I and z are shown to be more prevalent than previousl

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6

Sheldon, Jonathan Gary. "Control of ATP turnover." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627507.

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7

Woźnicka-Misăilă, Aleksandra. "An investigation and characterization of different ADP/ATP Carrier homologs." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV011/document.

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L'objectif principal de ce projet de thèse était d'obtenir de nouvelles données structurales sur les transporteurs ADP/ATP mitochondriaux et de développer des outils pour les approches de micro- et nano-cristallographie appliquées à la biologie structurale des protéines membranaires.Le rôle principal du transporteur ADP/ATP (AAC) est d'importer et d'exporter respectivement de l’ADP3- et l’ATP4- à travers la membrane mitochondriale interne, entre l'espace intermembranaire et la matrice. AAC est le transporteur mitochondrial le mieux caractérisé de toute cette famille de protéines. De nombreuses

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8

Rey, Martial. "Transporteur mitochondrial d'ATP/ADP : étude par échange hydrogène / deutérium couplé à la spectrométrie de masse et caractérisation de mutations pathogènes." Grenoble 1, 2009. http://www.theses.fr/2009GRE10320.

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Le tran'sporteur d'ADP/ATP est une protéine de la membrane interne mitochondriale qui joue un rôle physiologique majeur en catalysant l'échange d'un ADP cytoplasmique contre un A TP néo-synthétisé dans la matrice mitochondriale. Cette protéine peut être inhibée de manière très spécifique par deux poisons naturels, le carboxyatractyloside (CATR) et l'acide bongkrekique (BA) qui stabilisent la protéine dans deux états conformationnels distincts adoptés au cours du mécanisme de transport. Afin de mieux appréhender cette dynamique fonctionnelle, une étude du transporteur d'ADP/ATP bovin en complex

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9

Schaffer, Veronika. "Bestimmung der ATP-Freisetzung und des ATP-Abbaus an peripheren Nerven mittels Lumineszenzmessung." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-94932.

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10

Hendon, Tyler. "IMPACT OF PHOSPHOINOSITIDES ON REGULATION OF K-ATP BY ATP AND HYDROGEN SULFIDE." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5556.

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Hydrogen sulfide (H2S) reduces ischemia reperfusion (IR) injury by stimulating adenosine triphosphate (ATP) sensitive potassium channels (KATP) [1-5]. Demonstrating H2S stimulation is unique to KATP, as other inwardly rectifying potassium (Kir) channels demonstrate inhibition or are unaffected [6]. We recently showed that H2S inhibits Kir2 and Kir3 by decreasing channel sensitivity to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) [6]. Here, we test the hypothesis that H2S regulation of Kir6.2, a pore-forming subunit of the KATP channel, is also dependent on PIP2. Using whole-cell p

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11

Ashton, Valerie Lauren. "Probing the conformational changes of the yeast mitochondrial ADP/ATP carrier." Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/245071.

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The mitochondrial ADP/ATP carrier in the inner mitochondrial membrane imports ADP and exports ATP by switching between two conformational states. In the cytoplasmic state, which can be locked by carboxy-atractyloside, the substrate binding site is accessible to the cytoplasm, whereas in the matrix state, which can be locked by bongkrekic acid, the substrate binding site is open to the mitochondrial matrix. Access to the substrate binding site is regulated by salt bridge networks on either side of the central cavity, called the matrix and cytoplasmic salt bridge network. It has been proposed th

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12

Shatarat, Amjad. "ATP as a sympathetic neurotransmitter." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12069/.

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ATP has been shown to be a sympathetic neurotransmitter in blood vessels. However, its relative importance has been shown to be influenced by the experimental conditions employed such as alteration of the vascular tone. Thus the main aim was to raise the tone of vascular preparations and to further examine sympathetic neurotransmission in these preparations. Porcine whole mesenteries were perfused with physiological buffer and changes in pressure recorded or different sized mesenteric arteries were isolated and set up for isometric recording. Responses to electrical field stimulation (EFS) wer

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13

Wild, Julia Stephanie. "An Investigation into ATP Misses." Thesis, University of Canterbury. Engineering Management, 2014. http://hdl.handle.net/10092/8929.

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This project was carried out in order to complete the requirements of the Master of Engineering Management degree at the University of Canterbury. The project objective was to examine the reasons for Attainment to Plan (ATP) misses at the Meadow Fresh Christchurch plant, specifically the Fresh Beverages division. ATP is a measure of how closely the production team follows the daily packing plan, and is a site Key Performance Indicator (KPI). This report describes the action plans that were developed to decrease the number of misses to the target value, an analysis of the success of these plans

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14

Hamilton, Sara M. "ATP and peripheral sensory systems." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325538.

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15

Green-Petersen, Minna. "Mitochondrial alignment in ATP gradients." Thesis, KTH, Tillämpad fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-189551.

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16

Johansson, Monika. "The role of nucleoside diphosphate kinase in plant mitochondria /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200674.pdf.

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17

Weber, Cornelia [Verfasser]. "The challenge of ATP biosensing - application, investigation and further development of ATP microbiosensors / Cornelia Weber." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2014. http://d-nb.info/1049238877/34.

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18

Zheng, Jing-Sheng. "ATP receptors and regulation of the ATP-induced calcium ion mobilization response in cardiac myocytes." Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1056573774.

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19

Bamber, Lisa. "Yeast mitochondrial ADP/ATP carriers are monomers in detergent and in function." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612861.

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20

Claes, Richard John. "Discovery of inhibitors of the mitosomal ADP/ATP carrier from Entamoeba histolytica." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648445.

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21

Cerson, Elizabeth. "Structural and functional studies on mitochondrial ADP/ATP carriers of thermophilic organisms." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648816.

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22

Plante, Hendrick. "Production d'anticorps polyclonaux contre les récepteurs AT1 humain et ATp de poulet." Sherbrooke : Université de Sherbrooke, 1997.

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23

Hinchy, Elizabeth. "How cellular ATP/ADP ratios and reactive oxygen species affect AMPK signalling." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/270029.

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Mitochondria are key generators of cellular ATP, vital to complex life. Historically, mitochondrial generation of reactive oxygen species (ROS) was considered to be an unregulated process, produced by dysfunctional mitochondria. More recently, mitochondrial ROS generated by complex I, particularly by the process of reverse electron transfer (RET), has emerged as a potentially biologically relevant signal that is tightly-regulated and dependent on mitochondrial status. ROS production by RET is reported to play a role in the innate immune response and lifespan extension in fruit flies. One way i

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24

Kowalke, Julia Maria. "Chemosensitivitätstestung beim primären Mammakarzinom : individuelle Kreuzaktivität üblicher Chemotherapeutika ermittelt mit Hilfe des ATP-Tumorchemosensitivitätsassay (ATP-TCA) /." Köln, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000256392.

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25

Knust, Tobias [Verfasser], and Peter [Akademischer Betreuer] Graumann. "Regulation of SMC by associate proteins and ATP = Regulation von SMC durch assoziierte Proteine und ATP." Freiburg : Universität, 2011. http://d-nb.info/112345888X/34.

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26

Douglas, Corsten Perrie Louise Claire. "Studies of the assembly pathway of human ATP synthase." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267744.

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Human mitochondrial ATP synthase is an enzyme containing 18 unlike subunits located in the inner mitochondrial membrane (IMM), where the catalytic F1 domain extends into the mitochondrial matrix and the FO domain, which contains the c8-ring rotor, the a-subunit and the supernumerary subunits, is anchored in the IMM. All the subunits, apart from the a- and A6L-subunits, are encoded in the nucleus and require transport into the mitochondria before being assembled. The a- and A6L-subunits are encoded on the mitochondrial genome. The respiratory complexes generate the proton motive force (PMF), wh

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27

Ho, Wei Meng. "Single molecule characterisation of ATP Synthase." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533849.

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28

Klinker, Henrike. "ATP-dependent nucleosome sliding by ISWI." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-180992.

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29

Bowers, Keith Cyril. "Pathophysiology of ATP in single cardiomyocytes." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316576.

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30

Manning, Benjamin J. "ATP-Dependent Heterochromatin Remodeling: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/795.

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Eukaryotic DNA is incorporated into the nucleoprotein structure of chromatin. This structure is essential for the proper storage, maintenance, regulation, and function of the genomes’ constituent genes and genomic sequences. Importantly, cells generate discrete types of chromatin that impart distinct properties on genomic loci; euchromatin is an open and active compartment of the genome, and heterochromatin is a restricted and inactive compartment. Heterochromatin serves many purposes in vivo, from heritably silencing key gene loci during embryonic development, to preventing aberrant DNA repea

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31

Manning, Benjamin J. "ATP-Dependent Heterochromatin Remodeling: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/795.

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Eukaryotic DNA is incorporated into the nucleoprotein structure of chromatin. This structure is essential for the proper storage, maintenance, regulation, and function of the genomes’ constituent genes and genomic sequences. Importantly, cells generate discrete types of chromatin that impart distinct properties on genomic loci; euchromatin is an open and active compartment of the genome, and heterochromatin is a restricted and inactive compartment. Heterochromatin serves many purposes in vivo, from heritably silencing key gene loci during embryonic development, to preventing aberrant DNA repea

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32

Kimura, Yasuhisa. "Analysis of ATP hydrolysis activities of ABC transporters involved in multidrug resistance and K[ATP] channel regulation." Kyoto University, 2005. http://hdl.handle.net/2433/59289.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第11833号<br>農博第1523号<br>新制||農||918(附属図書館)<br>学位論文||H17||N4082(農学部図書室)<br>UT51-2005-K499<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授植田充美, 教授矢﨑一史<br>学位規則第4条第1項該当

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33

Macedo, Denise Vaz de 1959. "Envolvimento do carreador ADP/ATP nos processos de permeabilização da membrana mitocondrial interna." [s.n.], 1993. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314434.

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Orientador : Lucia Pereira da Silva<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-18T12:24:41Z (GMT). No. of bitstreams: 1 Macedo_DeniseVazde_D.pdf: 4866200 bytes, checksum: 168aa5c20312bef638bfa207ebc599b4 (MD5) Previous issue date: 1993<br>Resumo: Neste trabalho, apresentamos evidências experimentais suficientes para propor o envolvimento direto do carreador ADP/ATP no processo de abertura do poro dependente de Ca2+, responsável pelo fenômeno de transição de permeabilidade da membrana mitocondrial interna. Comparando a

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34

Moiseeva, Vera. "Caractérisation de l'état oligomérique du transporteur mitochondrial ADP/ATP dans des membranes natives." Thesis, Grenoble, 2012. http://www.theses.fr/2012GRENY018.

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Le passage sélectif de molécules à travers la membrane interne des mitochondries est essentiel aux processus métaboliques des cellules eucaryotes. Cette communication cellulaire est assurée par des protéines transmembranaires de la famille des transporteurs mitochondriaux (MCF). Le transporteur ADP/ATP (AAC) est le membre le plus connu et le mieux caractérisé de cette famille. Il est responsable de l'import d'ADP dans la matrice mitochondriale et de l'export d'ATP après synthèse vers le cytosol. La structure d'AAC est connue mais plusieurs questions restent ouvertes concernant le mécanisme du

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35

DI, MARINO DANIELE. "Molecular dynamics and docking simulations of the ADP/ATP mitochondrial carrier: structural-dynamical insights for the inactivation of pathological mutants and detection of potential ATP binding sites." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2010. http://hdl.handle.net/2108/1174.

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Il carrier mitocondriale ADP/ATP (AAC) è stato cristallizato in complesso con il suo inibitore carboxyatractyloside (CATR). La proteina è composta da un fascio di sei eliche trans membrana che forma un canale all'interno della membrane mitocondriale interna che si presenta chiuso verso il lato matriciale ed aperto verso lo spazio intermembrana, conformazione dovuta alla presenza di una prolina sulle eliche dispari che forma una piegatura dell' elica. Il ruolo di questa proteina è di importare ADP nella matrice mitocondriale ed esportare ATP nel citosol. L' insorgenza di alcune patologie è st

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36

Taher, Mohammed Ahmed A. "Hormonal regulation of ATP binding cassette transporters." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971837139.

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37

Qiu, Feng. "Regulation of Pannexin 1 Channels by ATP." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/394.

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Pannexins represent a recently discovered second family of gap junction proteins in vertebrates. However, instead of forming intercellular gap junction channels like connexins, pannexins operate as unpaired pannexons, allowing the flux of molecules from the cytoplasm to the extracellular space and vice versa. Pannexins appear to play a vital role in the local control loop of blood perfusion and oxygen delivery. The properties of Panx1 channels indicate that this protein is the most probable candidate for an ATP release channel and is involved in the propagation of intercellular calcium waves.

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38

Yang, Yuanjing. "ATP modulatory actions on hippocampal synaptic transmission." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ59415.pdf.

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39

Hauser, Dominik Roland Johannes. "Purinderivate als mögliche ATP-kompetitive Kinase Inhibitoren /." [S.l. : s.n.], 2004. http://www.gbv.de/dms/bs/toc/396990371.pdf.

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40

Bélanger, Danny. "Heterologous functional interactions of P2X ATP receptors." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81596.

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Part I. In this work we show that P2X3 currents are acutely modulated by the GPCRs mGluR5 and P2Y2, and by the neurotrophin TrkA receptor, expressed in nociceptors, in the recombinant Xenopus oocyte system. The intracellular C-terminal domain of P2X 3 plays an important role in its functional coupling to TrkA. Preliminary studies suggest a role for PKC in the P2X3-TrkA cross-talk, but other routes may also contribute. Part II. Neurogenic and pharmacological stimulation of vascular smooth muscle P2X1 elicits a contractile response that we found was potentiated by serotonin acting through

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41

Chabot-Doré, Anne-Julie. "Metabotropic regulation of ATP-gated P2X3 receptors." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101708.

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Among the ATP-gated channels, the P2X3 subtype is exclusively expressed in nociceptors of dorsal root ganglia (DRG) and trigeminal ganglia, where it plays a major role in enhanced pain sensation observed in chronic pain states. We tested the hypothesis that P2X3 receptors are modulated by metabotropic receptors, such as 5-HT2A, mG1uR5 and trkA, leading to increased P2X3-mediated currents. Double fluorescence labeling confirmed that P2X3-expressing neurons are labeled by the lectin IB4 and we showed that 5-HT2A and mGluR5 receptors, but not trkA, are expressed in a fraction of IB4-positive neur

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42

Dyer, Mark Richard. "Nuclear genes for mammalian mitochondrial ATP synthase." Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.256750.

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43

Contin, Marco. "ATP concentration in the soil microbial biomass." Thesis, Coventry University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270692.

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44

Huckstepp, Robert T. R. "ATP and mechanisms of central CO2 chemosensitivity." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/2760/.

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ATP release from the surface of the ventro-lateral medulla (VLM) is integral to the hypercapnic response in vivo and can be seen in vitro. By employing horizontal slices of the ventral medulla containing the ventral chemosensitive nuclei, I have developed a model that consistently evokes hypercapnia-induced ATP release in vitro. Using this preparation I have studied CO2-triggered ATP release by means of microelectrode biosensors. I conclude that it is the change in PCO2 itself, and not associated pH changes that accompany it, that is directly responsible for eliciting ATP release from the surf

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45

Smith, Andrew James. "Membrane trafficking of ATP-sensitive potassium channels." Thesis, University of Leeds, 2005. http://etheses.whiterose.ac.uk/365/.

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ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is known how the number of channels at the cell surface is regulated. The number of channels in the plasma membrane could be regulated in two ways; firstly by regulating the overall population of channels within the cells by increasing/decreasing the rates of channel synthesis or degradation, and secondly by regulating the insertion and removal of

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46

Gray, Christopher H. "ATP-binding cassette transporters of Paracoccidiodes brasiliensis." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342042.

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47

Cozens, A. L. "ATP synthase genes in cyanobacteria and chloroplasts." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383121.

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48

Rabindran, Ray 1964. "Inhibition of tau kinase activity by ATP." Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/47691.

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49

Smith, Katherine Sue. "Autocrine/paracrine regulation of ATP citrate lyase /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487683401444039.

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50

Thomas, Collin Ernest. "Extracellular ATP : transport, metabolism, and physiological significance /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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