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Dissertations / Theses on the topic 'Atp9'

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Published: 4 June 2021
Last updated: 17 February 2022

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1

Bietenhader, Maïlis. "Relocalisation nucléaire du gène mitochondrial ATP9 chez la levure Saccharomyces cerevisiae." Thesis, Bordeaux 2, 2009. http://www.theses.fr/2009BOR21691/document.

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L'ancêtre a-protéobactérie endosymbiotique à l'origine des mitochondries avait son propre génome, codant pour de nombreuses fonctions redondantes, voire totalement inutiles dans la cellule hôte. Ces informations ont disparu avec le temps, alors que les autres gènes indispensables ont en grande partie été transférés au noyau de la cellule eucaryote. Aujourd'hui, plus de quatre vingt quinze pourcents des protéines mitochondriales sont codées par le génome nucléaire. La question se pose de savoir pourquoi ces gènes sont maintenus dans les organites. Une manière de répondre expérimentalement à cet
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2

Pesce, Adam S. "RNA editing and mutagenesis of the soybean (Glycine max) mitochondrial atp9 gene." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-07292009-090345/.

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3

Drager, Robert Gray. "Structure and transcript processing of a Euglena gracilis chloroplast operon encoding genes rps2, atpI, atpH, atpF, atpA and rps18." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186334.

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A 9.8 kbp region of the Euglena gracilis chloroplast genome has been cloned, sequenced and analyzed. This region contains six genes, rps2, rps18, atpI, atpH, atpF and atpA which encode ribosomal proteins S2 and S18 and ATP synthase subunits CFₒIV, CFₒIII, CFₒI and CF₁α, respectively. The linear order of these genes, 5'-rps2-atpI-atpH-atpF-atpA-rps18-3', is similar to that of land plant chloroplasts. These six genes are co-transcribed with two tRNA genes which are 5' to rps2. A fully spliced, 5.5 kb transcript containing all six genes accumulates. The spliced hexa-cistronic transcript is proces
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4

Breuil, Norman. "Conséquences de dysfonctionnements mitochondriaux chez le nématode Caenorhabditis elegans : étude de trois gènes nucléaire ant-1.1, osgl-1 et atp-9." Paris 11, 2009. http://www.theses.fr/2009PA112363.

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Les maladies mitochondriales sont des pathologies qui se traduisent par des dysfonctionnements neuromusculaires graves. Au niveau moléculaire, ces mutations affectent in fine le fonctionnement de la chaîne respiratoire, la structure du réseau mitochondrial et la stabilité du génome mitochondrial. Une meilleure compréhension de la physiopathologie sous-jacente à ces maladies nécessite le développement de modèles expérimentaux. Le nématode Caenorhabditis elegans a été choisi comme organisme modèle pour étudier certaines de ces pathologies. La famille de gènes nucléaires codant pour le transporte
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5

Hernould, Michel. "Etude de l'expression chez des plantes transgéniques, d'un gène mitochondrial non-édité (atp9) : effet sur la fertilité." Bordeaux 2, 1993. http://www.theses.fr/1993BOR28229.

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6

Suharsono. "Effet du gène mitochondrial atp9 non-édité sur la fertilité, chez des plantes transgéniques de nicotiana tabacum." Bordeaux 2, 1993. http://www.theses.fr/1993BOR28256.

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7

Heisler, Helma. "Untersuchung des RNA-Editings in Pflanzenorganellen Entwicklung eines Verfahrens zur Identifizierung von cis-Elementen am Beispiel der atp9-RNA in In-vitro- und In-organello-Systemen /." [S.l. : s.n.], 2003. http://www.diss.fu-berlin.de/2003/54/index.html.

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8

Guelin, Emmanuel. "L'ATP synthase mitochondriale de levure : clonage et séquençage des gènes mitochondriaux ATP6 et ATP8. Clonage, séquençage et délétion du gène nucléaire ATP-E." Bordeaux 2, 1992. http://www.theses.fr/1992BOR28205.

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9

Su, Xin. "Yeast models of diseases linked to the mitochondrial ATP6 gene : molecular bases and therapeutic prospects." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0216.

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Par définition, les maladies mitochondriales résultent d’un défaut dans le processus des oxydations phosphorylantes (OXPHOS). Celui-ci permet aux cellules de se fournir en ATP, soit la principale source d’énergie qu’elles peuvent utiliser. Dans ce processus, quatre complexes (I-IV) insérés dans la membrane mitochondriale interne transfèrent à l’oxygène moléculaire les équivalents réducteurs libérés par l’oxydation de carbohydrates et d’acides gras. Cette activité génère une force proton motrice utilisée pour la synthèse d’ATP à partir d’ADP et de phosphate inorganique par le complexe V ou ATP
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10

RIMBAULT, BLANDINE. "Etude de l'expression des genes chloroplastiques atpa et atpb, codant pour les sous unites et de l'atp synthetase, dans l'algue verte c. Reinhardtii." Paris 11, 2001. http://www.theses.fr/2001PA112043.

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L'origine endosymbiotique des chloroplastes se manifeste par le transfert de nombreux genes, a partir de l'ancetre procaryote, dans le genome nucleaire. L'existence, pour chaque complexe de l'appareil photosynthetique, de sous unites codees par le genome nucleaire et d'autres codees par le chloroplaste implique une regulation de l'expression des genes, afin que les sous unites soient produites dans les proportions requises pour leur assemblage. Les travaux presentes dans notre these concernent la regulation de l'expression de deux genes chloroplastiques de l'algue verte c. Reinhardtii, atpa et
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11

Duong, Khanh Viet. "On Enhancing Deterministic Sequential ATPG." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/31283.

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This thesis presents four different techniques for improving the average-case performance of deterministic sequential circuit Automatic Test Patterns Generators (ATPG). Three techniques make use of information gathered during test generation to help identify more unjustifiable states with higher percentage of â donâ t careâ value. An approach for reducing the search space of the ATPG was introduced. The technique can significantly reduce the size of the search space but cannot ensure the completeness of the search. Results on ISCASâ 85 benchmark circuits show that all of the proposed tech
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12

Finegan, Brian H., and Gary Singer. "ADVANCED TELEMETRY PROCESSING SYSTEM (ATPS)." International Foundation for Telemetering, 1994. http://hdl.handle.net/10150/608547.

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International Telemetering Conference Proceedings / October 17-20, 1994 / Town & Country Hotel and Conference Center, San Diego, California<br>The Advanced Telemetry Processing System (ATPS) is the result of a joint development project between Harris Corporation and Veda Systems, Incorporated. The mission of the development team was to produce a high-performance, cost-effective, supportable telemetry system; one that would utilize commercial-off-the-shelf (COTS) hardware and software, thereby eliminating costly customization typically required for range and telemetry applications. A criti
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13

Harrington, R. A. "Evolution of ATP synthase." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603734.

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The hypothesis of modular evolution of the <i>atp</i> operon is re-evaluated by conducting a phylogenetic analysis of the <i>atp</i> operons and constituent genes of all fully sequenced genomes. Although the original hypothesis of modular evolution cannot be conclusively supported, a number of novel observations are made. Foremost is that the <i>atp</i> operon is a mosaic operon, a result of extensive horizontal transfer. In addition, two independent duplication events are proposed for subunits b/b’ of the enzyme, the transmembrane subunits I and z are shown to be more prevalent than previousl
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14

Sheldon, Jonathan Gary. "Control of ATP turnover." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627507.

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15

Schaffer, Veronika. "Bestimmung der ATP-Freisetzung und des ATP-Abbaus an peripheren Nerven mittels Lumineszenzmessung." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-94932.

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16

Hendon, Tyler. "IMPACT OF PHOSPHOINOSITIDES ON REGULATION OF K-ATP BY ATP AND HYDROGEN SULFIDE." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5556.

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Hydrogen sulfide (H2S) reduces ischemia reperfusion (IR) injury by stimulating adenosine triphosphate (ATP) sensitive potassium channels (KATP) [1-5]. Demonstrating H2S stimulation is unique to KATP, as other inwardly rectifying potassium (Kir) channels demonstrate inhibition or are unaffected [6]. We recently showed that H2S inhibits Kir2 and Kir3 by decreasing channel sensitivity to phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) [6]. Here, we test the hypothesis that H2S regulation of Kir6.2, a pore-forming subunit of the KATP channel, is also dependent on PIP2. Using whole-cell p
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17

Douglas, Corsten Perrie Louise Claire. "Studies of the assembly pathway of human ATP synthase." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267744.

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Human mitochondrial ATP synthase is an enzyme containing 18 unlike subunits located in the inner mitochondrial membrane (IMM), where the catalytic F1 domain extends into the mitochondrial matrix and the FO domain, which contains the c8-ring rotor, the a-subunit and the supernumerary subunits, is anchored in the IMM. All the subunits, apart from the a- and A6L-subunits, are encoded in the nucleus and require transport into the mitochondria before being assembled. The a- and A6L-subunits are encoded on the mitochondrial genome. The respiratory complexes generate the proton motive force (PMF), wh
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18

Ivanov, André. "Dynamic testibility measures and their use in ATPG." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=63324.

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19

Cota, Erika Fernandes. "ATPG para teste de circuitos analogicos e mistos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 1997. http://hdl.handle.net/10183/117097.

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Este trabalho tem como objetivo realizar um estudo do problema de teste de circuitos analógicos e mistos, propondo uma metodologia de teste e apresentando uma ferramenta para geração automática de vetores de teste (ATPG). A necessidade deste tipo de pesquisa torna-se clara no momento em que um número cada vez maior de aplicações requer algum tipo de interação entre dispositivos analógicos e digitais, não só em se tratando de placas de circuito impresso, mas também em um mesmo circuito integrado. A metodologia prevê a detecção de falhas paramétricas, de grandes desvios e catastróficas em circui
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20

Gupta, Puneet. "High Quality Transition and Small Delay Fault ATPG." Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/9725.

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Path selection and generating tests for small delay faults is an important issue in the delay fault area. A novel technique for generating effective vectors for delay defects is the first issue that we have presented in the thesis. The test set achieves high path delay fault coverage to capture small-distributed delay defects and high transition fault coverage to capture gross delay defects. Furthermore, non-robust paths for ATPG are filtered (selected) carefully so that there is a minimum overlap with the already tested robust paths. A relationship between path delay fault model and transitio
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21

Liu, Xiao. "ATPG and DFT Algorithms for Delay Fault Testing." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/11213.

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With ever shrinking geometries, growing metal density and increasing clock rate on chips, delay testing is becoming a necessity in industry to maintain test quality for speed-related failures. The purpose of delay testing is to verify that the circuit operates correctly at the rated speed. However, functional tests for delay defects are usually unacceptable for large scale designs due to the prohibitive cost of functional test patterns and the difficulty in achieving very high fault coverage. Scan-based delay testing, which could ensure a high delay fault coverage at reasonable development cos
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22

Vontela, Deepak Reddy. "Methodologies to Exploit ATPG Tools for De-camouflaging." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6597.

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Semiconductor supply chain is increasingly getting exposed to Reverse Engineering (RE) of Intellectual Property (IP). Camouflaging of gates in integrated circuits are typically employed to hide the gate functionality to prevent reverse engineering. The functionalities of these gates cannot be found by De-layering as they don’t leave any layout clues. Adversaries perform reverse engineering by replacing the camouflaged gate with the known gate and by developing custom software to determine test patterns. These test patterns are used to analyze the outputs and to conclude the functionality of th
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23

Kramarova, Tatiana. "Limiting factors in ATP synthesis." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-987.

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24

Shatarat, Amjad. "ATP as a sympathetic neurotransmitter." Thesis, University of Nottingham, 2011. http://eprints.nottingham.ac.uk/12069/.

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ATP has been shown to be a sympathetic neurotransmitter in blood vessels. However, its relative importance has been shown to be influenced by the experimental conditions employed such as alteration of the vascular tone. Thus the main aim was to raise the tone of vascular preparations and to further examine sympathetic neurotransmission in these preparations. Porcine whole mesenteries were perfused with physiological buffer and changes in pressure recorded or different sized mesenteric arteries were isolated and set up for isometric recording. Responses to electrical field stimulation (EFS) wer
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25

Wild, Julia Stephanie. "An Investigation into ATP Misses." Thesis, University of Canterbury. Engineering Management, 2014. http://hdl.handle.net/10092/8929.

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This project was carried out in order to complete the requirements of the Master of Engineering Management degree at the University of Canterbury. The project objective was to examine the reasons for Attainment to Plan (ATP) misses at the Meadow Fresh Christchurch plant, specifically the Fresh Beverages division. ATP is a measure of how closely the production team follows the daily packing plan, and is a site Key Performance Indicator (KPI). This report describes the action plans that were developed to decrease the number of misses to the target value, an analysis of the success of these plans
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26

Hamilton, Sara M. "ATP and peripheral sensory systems." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325538.

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27

Green-Petersen, Minna. "Mitochondrial alignment in ATP gradients." Thesis, KTH, Tillämpad fysik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-189551.

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28

Gent, Kelson Andrew. "High Quality Test Generation at the Register Transfer Level." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/73544.

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Integrated circuits, from general purpose microprocessors to application specific designs (ASICs), have become ubiquitous in modern technology. As our applications have become more complex, so too have the circuits used to drive them. Moore's law predicts that the number of transistors on a chip doubles every 18-24 months. This explosion in circuit size has also lead to significant growth in testing effort required to verify the design. In order to cope with the required effort, the testing problem must be approached from several different design levels. In particular, exploiting the Register
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29

Weber, Cornelia [Verfasser]. "The challenge of ATP biosensing - application, investigation and further development of ATP microbiosensors / Cornelia Weber." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 2014. http://d-nb.info/1049238877/34.

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30

Zheng, Jing-Sheng. "ATP receptors and regulation of the ATP-induced calcium ion mobilization response in cardiac myocytes." Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1056573774.

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31

Daher, Raed. "Implication de BMP6, GLRX5 et la H+/K+ ATPase dans les troubles du métabolisme de fer : de la physiologie à la pathologie." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC280.

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Le fer est un élément essentiel à de nombreux processus biologiques. Son homéostasie est maintenue par un mécanisme clos qui se base sur son absorption au niveau de l'intestin, son utilisation par les précurseurs érythroïdes pour produire l’hémoglobine, et son recyclage et stockage dans les macrophages du foie et de la rate. Le métabolisme du fer est sous le contrôle négatif de l'hepcidine, un peptide synthétisé essentiellement par le foie. L'hepcidine inhibe l'absorption intestinale du fer ainsi que son relargage des macrophages. Le déséquilibre du métabolisme du fer entraîne
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32

Fai͏̈sse, Bruno. "Effets de l'ATP sur le tonus veineux chez l'homme : évaluation par pléthysmographie d'occlusion." Montpellier 1, 1989. http://www.theses.fr/1989MON11126.

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33

Knust, Tobias [Verfasser], and Peter [Akademischer Betreuer] Graumann. "Regulation of SMC by associate proteins and ATP = Regulation von SMC durch assoziierte Proteine und ATP." Freiburg : Universität, 2011. http://d-nb.info/112345888X/34.

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34

Kowalke, Julia Maria. "Chemosensitivitätstestung beim primären Mammakarzinom : individuelle Kreuzaktivität üblicher Chemotherapeutika ermittelt mit Hilfe des ATP-Tumorchemosensitivitätsassay (ATP-TCA) /." Köln, 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000256392.

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35

Shanyour, Basim. "Testing and Security Considerations in Presence of Process Variations." OpenSIUC, 2020. https://opensiuc.lib.siu.edu/dissertations/1804.

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Process variations is one of the most challenging phenomena in deep submicron. Delay fault testing becomes more complicated because gate delays are not fixed but instead, they are statistical quantities due to the variations in the transistor characteristics. On the other hand, testing for hardware Trojan is also challenging in the presence of process variations because it can easily mask the impact of the inserted Trojan. This work consists of two parts. In the first part, an approach to detect ultra-low-power no-payload Trojans by analyzing IDDT waveforms at each gate in the presence of proc
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36

Tyagi, Dhawal. "TENOR : an ATPG for transition faults in combinational circuits /." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-06302009-040525/.

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37

Ford, Gregory Fick. "Hardware Emulation of Sequential ATPG-Based Bounded Model Checking." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1384265165.

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38

Young, A. R. J. "Characterisation of mammalian Atg9 and its role in autophagy." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445191/.

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Cells undergo autophagy or self-eating as a means of recycling their constituents in order to maintain homeostasis. Autophagy is up regulated by stress, including amino acid deprivation for which it is best characterised. Upon amino acid starvation double or multiple lamellar vesicles termed autophagic vacuoles (AV) or autophagosomes appear throughout the cell's cytoplasm. From their content they can be seen to have sequestered cytoplasm, often including organelles. Screens for autophagy defective mutants in Saccharomyces cerevisiae resulted in the AuTophaGy (ATG) genes. I have studied the ubi
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39

Ho, Wei Meng. "Single molecule characterisation of ATP Synthase." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533849.

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40

Klinker, Henrike. "ATP-dependent nucleosome sliding by ISWI." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-180992.

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41

Bowers, Keith Cyril. "Pathophysiology of ATP in single cardiomyocytes." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316576.

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42

Manning, Benjamin J. "ATP-Dependent Heterochromatin Remodeling: A Dissertation." eScholarship@UMMS, 2009. http://escholarship.umassmed.edu/gsbs_diss/795.

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Eukaryotic DNA is incorporated into the nucleoprotein structure of chromatin. This structure is essential for the proper storage, maintenance, regulation, and function of the genomes’ constituent genes and genomic sequences. Importantly, cells generate discrete types of chromatin that impart distinct properties on genomic loci; euchromatin is an open and active compartment of the genome, and heterochromatin is a restricted and inactive compartment. Heterochromatin serves many purposes in vivo, from heritably silencing key gene loci during embryonic development, to preventing aberrant DNA repea
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Manning, Benjamin J. "ATP-Dependent Heterochromatin Remodeling: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/795.

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Eukaryotic DNA is incorporated into the nucleoprotein structure of chromatin. This structure is essential for the proper storage, maintenance, regulation, and function of the genomes’ constituent genes and genomic sequences. Importantly, cells generate discrete types of chromatin that impart distinct properties on genomic loci; euchromatin is an open and active compartment of the genome, and heterochromatin is a restricted and inactive compartment. Heterochromatin serves many purposes in vivo, from heritably silencing key gene loci during embryonic development, to preventing aberrant DNA repea
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44

Lange, Ulf. "Elektrophysiologische Untersuchungen an rekombinanten kardiovaskulären K ATP -Kanälen Effekte von Nukleotiden, neuartigen K ATP -Kanalöffnern und Blockern /." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11947832.

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45

Kimura, Yasuhisa. "Analysis of ATP hydrolysis activities of ABC transporters involved in multidrug resistance and K[ATP] channel regulation." Kyoto University, 2005. http://hdl.handle.net/2433/59289.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第11833号<br>農博第1523号<br>新制||農||918(附属図書館)<br>学位論文||H17||N4082(農学部図書室)<br>UT51-2005-K499<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授 植田 和光, 教授 植田 充美, 教授 矢﨑 一史<br>学位規則第4条第1項該当
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Lenox, Joseph Daniel. "PARALLEL DELAY FAULT GRADING HEURISTIC AND TESTING APPROACHES TO TROJAN IC DETECTION." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1315.

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A method to perform implicit path delay fault grading on GPGPU architectures is presented. Experimentally it is shown that it is over 1200x faster than a single-core implicit path delay fault grading method previously in the literature for higher accuracy and can be shown to scale to multiple GPGPUs. A post-silicon test pattern generation strategy to maximize the efficiency of broadside tests applied to a sequential design for a limited test budget is presented. Arguments are made for this approach for detecting embedded Trojan ICs in the next-state functions of a sequential system; they are
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47

Samala, Keerthana. "Test Pattern Generation for Double Transition faults." OpenSIUC, 2018. https://opensiuc.lib.siu.edu/theses/2374.

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Keerthana Samala, for the Master of Science degree in Electrical and Computer, presented on 05/11/2018, at Southern Illinois University Carbondale. TITLE: Test Pattern Generation for Double Transition Faults MAJOR PROFESSOR: Dr. Spyros Tragoudas Under double transition fault model, a fault is associated with a pair of lines and a pair of transitions on these lines. The proposed double transition fault model includes set of cases where the increased delay of a single faulty line may be too small to cause the faulty behavior of the circuit. However, when this delay propagates through another fau
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48

Karunaratne, Maddumage Don Gamini. "An intelligent function level backward state justification search for ATPG." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184921.

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This dissertation describes an innovative approach to the state justification portion of the sequential circuit automatic test pattern generation (ATPG) process. Given the absence of a stored fault an ATPG controller invokes some combinational circuit test generation procedure, such as the D-algorithm, to identify a circuit state (goal state) and input vectors that will sensitize a selected fault. The state justification phase then finds a transfer sequence to the goal from the present state. A forward fault propogation search can be successfully guided through state space from the present sta
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49

Chandrasekar, Kameshwar. "ATPG based Preimage Computation: Efficient Search Space Pruning using ZBDD." Thesis, Virginia Tech, 2003. http://hdl.handle.net/10919/34218.

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Preimage Computation is a fundamental step in Formal Verification of VLSI designs. Conventional OBDD-based methods for Formal Verification suffer from spatial explosion, since large designs can blow up in terms of memory. On the other hand, SAT/ATPG based methods are less demanding on memory. But the run-time can be huge for these methods, since they must explore an exponential search space. In order to reduce this temporal explosion of SAT/ATPG based methods, efficient learning techniques are needed. <p> Conventional ATPG aims at computing a single solution for its objective. In preim
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Qiu, Feng. "Regulation of Pannexin 1 Channels by ATP." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/394.

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Pannexins represent a recently discovered second family of gap junction proteins in vertebrates. However, instead of forming intercellular gap junction channels like connexins, pannexins operate as unpaired pannexons, allowing the flux of molecules from the cytoplasm to the extracellular space and vice versa. Pannexins appear to play a vital role in the local control loop of blood perfusion and oxygen delivery. The properties of Panx1 channels indicate that this protein is the most probable candidate for an ATP release channel and is involved in the propagation of intercellular calcium waves.
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