Relevant bibliographies by topics / ATPL

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Academic literature on the topic 'ATPL'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "ATPL"

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Das, Amaresh, and Lars G. Ljungdahl. "Clostridium pasteurianum F1Fo ATP Synthase: Operon, Composition, and Some Properties." Journal of Bacteriology 185, no. 18 (September 15, 2003): 5527–35. http://dx.doi.org/10.1128/jb.185.18.5527-5535.2003.

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ABSTRACT The atp operon encoding F1Fo ATP synthase in the fermentative obligate anaerobic bacterium Clostridium pasteurianum was sequenced. It consisted of nine genes arranged in the order atpI(i), atpB(a), atpE(c), atpF(b), atpH(δ), atpA(α), atpG(γ), atpD(β), and atpC(ε), which was identical to that found in many bacteria. Reverse transcription-PCR confirmed the presence of the transcripts of all nine genes. The amount of ATPase activity in the membranes of C. pasteurianum was low compared to what has been found in many other bacteria. The F1Fo complexes solubilized from membranes of C. pasteurianum and Escherichia coli had similar masses, suggesting similar compositions for the F1Fo complexes from the two bacteria. Western blotting experiments with antibodies raised against the purified subunits of F1Fo detected the presence of eight subunits, α, β, γ, δ, ε, a, b, and c, in the F1Fo complex from C. pasteurianum. The F1Fo complex from C. pasteurianum was activated by thiocyanate, cyanate, or sulfhydryl compounds; inhibited by sulfite, bisulfite, or bicarbonate; and had tolerance to inhibition by dicyclohexylcarbodiimide. The target of thiol activation of the F1Fo complex from C. pasteurianum was F1. Thiocyanate and sulfite were noncompetitive with respect to substrate Mg ATP but competitive with respect to each other. The F1 and Fo parts of the F1Fo complexes from C. pasteurianum and E. coli bound to each other, but the hybrid F1Fo complexes were not functionally active.
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Huitric, E., P. Verhasselt, A. Koul, K. Andries, S. Hoffner, and D. I. Andersson. "Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor." Antimicrobial Agents and Chemotherapy 54, no. 3 (December 28, 2009): 1022–28. http://dx.doi.org/10.1128/aac.01611-09.

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ABSTRACT R207910 (also known as TMC207) is an investigational drug currently in clinical studies for the treatment of multidrug-resistant (MDR) tuberculosis. It has a high degree of antimycobacterial activity and is equally effective against drug-susceptible and MDR Mycobacterium tuberculosis isolates. In the present study, we characterized the development of resistance to R207910 in vitro. Ninety-seven independent R207910-resistant mutants were selected from seven different clinical isolates of M. tuberculosis (three drug-susceptible and four MDR isolates) at 10×, 30×, and 100× the MIC. At a concentration of 0.3 mg/liter (10× the MIC), the mutation rates ranged from 4.7 × 10−7 to 8.9 × 10−9 mutations per cell per division, and at 1.0 mg/liter (30× the MIC) the mutation rate ranged from 3.9 × 10−8 to 2.4 × 10−9. No resistant mutants were obtained at 3 mg/liter (100× the MIC). The level of resistance ranged from 0.12 to 3.84 mg/liter for the mutants identified; these concentrations represent 4- to 128-fold increases in the MICs. For 53 of the resistant mutants, the atpE gene, which encodes a transmembrane and oligomeric C subunit of the ATP synthase and which was previously shown to be involved in resistance, was sequenced. For 15/53 mutants, five different point mutations resulting in five different amino acid substitutions were identified in the atpE gene. For 38/53 mutants, no atpE mutations were found and sequencing of the complete F0 ATP synthase operon (atpB, atpE, and atpF genes) and the F1 ATP synthase operon (atpH, atpA, atpG, atpD, and atpC genes) from three mutants revealed no mutations, indicating other, alternative resistance mechanisms. Competition assays showed no measurable reduction in the fitness of the mutants compared to that of the isogenic wild types.
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Huang, Qiuyuan, Li Deng, Dapeng Wu, Chang Liu, and Xiaodong He. "Attentive Tensor Product Learning." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 1344–51. http://dx.doi.org/10.1609/aaai.v33i01.33011344.

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This paper proposes a novel neural architecture — Attentive Tensor Product Learning (ATPL) — to represent grammatical structures of natural language in deep learning models. ATPL exploits Tensor Product Representations (TPR), a structured neural-symbolic model developed in cognitive science, to integrate deep learning with explicit natural language structures and rules. The key ideas of ATPL are: 1) unsupervised learning of role-unbinding vectors of words via the TPR-based deep neural network; 2) the use of attention modules to compute TPR; and 3) the integration of TPR with typical deep learning architectures including long short-term memory and feedforward neural networks. The novelty of our approach lies in its ability to extract the grammatical structure of a sentence by using role-unbinding vectors, which are obtained in an unsupervised manner. Our ATPL approach is applied to 1) image captioning, 2) part of speech (POS) tagging, and 3) constituency parsing of a natural language sentence. The experimental results demonstrate the effectiveness of the proposed approach in all these three natural language processing tasks.
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Barriuso-Iglesias, Mónica, Carlos Barreiro, Fabio Flechoso, and Juan F. Martín. "Transcriptional analysis of the F0F1 ATPase operon of Corynebacterium glutamicum ATCC 13032 reveals strong induction by alkaline pH." Microbiology 152, no. 1 (January 1, 2006): 11–21. http://dx.doi.org/10.1099/mic.0.28383-0.

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Corynebacterium glutamicum, a soil Gram-positive bacterium used for industrial amino acid production, was found to grow optimally at pH 7·0–9·0 when incubated in 5 litre fermenters under pH-controlled conditions. The highest biomass was accumulated at pH 9·0. Growth still occurred at pH 9·5 but at a reduced rate. The expression of the pH-regulated F0F1 ATPase operon (containing the eight genes atpBEFHAGDC) was induced at alkaline pH. A 7·5 kb transcript, corresponding to the eight-gene operon, was optimally expressed at pH 9·0. The same occurred with a 1·2 kb transcript corresponding to the atpB gene. RT-PCR studies confirmed the alkaline pH induction of the F0F1 operon and the existence of the atpI gene. The atpI gene, located upstream of the F0F1 operon, was expressed at a lower level than the polycistronic 7·5 kb mRNA, from a separate promoter (P-atp1). Expression of the major promoter of the F0F1 operon, designated P-atp2, and the P-atp1 promoter was quantified by coupling them to the pET2 promoter-probe vector. Both P-atp1 and P-atp2 were functional in C. glutamicum and Escherichia coli. Primer extension analysis identified one transcription start point inside each of the two promoter regions. The P-atp1 promoter fitted the consensus sequence of promoters recognized by the vegetative σ factor of C. glutamicum, whereas the −35 and −10 boxes of P-atp2 fitted the consensus sequence for σ H-recognized Mycobacterium tuberculosis promoters CC/GGGA/GAC 17–22 nt C/GGTTC/G, known to be involved in expression of heat-shock and other stress-response genes. These results suggest that the F0F1 operon is highly expressed at alkaline pH, probably using a σ H RNA polymerase.
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Stahl, Dietmar, Steven R. Rodermel, Alap R. Subramanian, and Lawrence Bogorad. "Nucleotide sequence of a 3.46 kb region of maize chloroplast DNA containing the gene clusterrpoC2-rps2-atpl-atpH." Nucleic Acids Research 18, no. 10 (1990): 3073–74. http://dx.doi.org/10.1093/nar/18.10.3073.

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Cece, Valérian, Emma Guillet-Descas, and Guillaume Martinent. "Revue de méthodes longitudinales pour examiner la dynamique des émotions en contexte compétitif." Movement & Sport Sciences - Science & Motricité, no. 105 (2019): 79–88. http://dx.doi.org/10.1051/sm/2019009.

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L’étude des émotions en sport s’est largement développée ces dernières années par l’exploration de leur dynamique et la reconnaissance du rôle du contexte social dans leur déclenchement. Le choix de l’utilisation d’une méthodologie appropriée au regard des objectifs de l’étude revêt ainsi une importance particulière. Cet article propose une revue des méthodes longitudinales permettant de modéliser les processus émotionnels en se centrant sur trois approches prometteuses et relativement récentes : les analyses de classe latente de courbes de croissances (ACLCC), les analyses de transitions de profils latents (ATPL) et les analyses multiniveaux. Les avantages et les inconvénients de chacune sont discutés en s’appuyant sur des exemples issus de la littérature scientifique. Tandis que les ATPL permettent de capturer la dynamique des profils en abordant le concept émotionnel dans son ensemble, les ACLCC sont davantage pertinentes pour modéliser l’hétérogénéité de la dynamique d’une émotion par l’identification de différentes trajectoires. Enfin, les analyses multiniveaux sont particulièrement utiles pour distinguer ce qui relève d’un contexte social (e.g., centre d’entraînement intensif) de ce qui relève de l’individu. Une attention particulière a été accordée à la pertinence de ces méthodes pour examiner le rôle du contexte social interpersonnel dans la complexité des processus émotionnels.
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Lee, Eung Gwan, Jeong Seock Seo, Min Ho Cha, Mi Chung Suh, and Woong Seop Sim. "Cytokinin stimulates expression of the chloroplast ATP synthase VI subunit gene (atpl)." Journal of Plant Biology 45, no. 2 (June 2002): 71–76. http://dx.doi.org/10.1007/bf03030286.

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Martín-Galiano, Antonio J., Luz Balsalobre, Asunción Fenoll, and Adela G. de la Campa. "Genetic Characterization of Optochin-Susceptible Viridans Group Streptococci." Antimicrobial Agents and Chemotherapy 47, no. 10 (October 2003): 3187–94. http://dx.doi.org/10.1128/aac.47.10.3187-3194.2003.

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ABSTRACT Two clinical isolates of viridans group streptococci (VS) with different degrees of susceptibility to optochin (OPT), i.e., fully OPT-susceptible (Opts) VS strain 1162/99 (for which the MIC was equal to that for Streptococcus pneumoniae, 0.75 μg/ml) and intermediate Opts VS strain 1174/97 (MIC, 6 μg/ml) were studied. Besides being OPT susceptible, they showed characteristics typical of VS, such as bile insolubility; lack of reaction with pneumococcal capsular antibodies; and lack of hybridization with rRNA (AccuProbe)-, lytA-, and pnl-specific pneumococcal probes. However, these VS Opts strains and VS type strains hybridized with ant, a gene not present in S. pneumoniae. A detailed characterization of the genes encoding the 16S rRNA and SodA classified isolates 1162/99 and 1174/97 as Streptococcus mitis. Analysis of the atpCAB region, which encodes the c, a, and b subunits of the F0F1 H+-ATPase, the target of optochin, revealed high degrees of similarity between S. mitis 1162/99 and S. pneumoniae in atpC, atpA, and the N terminus of atpB. Moreover, amino acid identity between S. mitis 1174/97 and S. pneumoniae was found in α helix 5 of the a subunit. The organization of the chromosomal region containing the atp operon of the two Opts VS and VS type strains was spr1284-atpC, with spr1284 being located 296 to 556 bp from atpC, whereas in S. pneumoniae this distance was longer than 68 kb. In addition, the gene order in S. pneumoniae was IS1239-74 bp-atpC. The results suggest that the full OPT susceptibility of S. mitis 1162/99 is due to the acquisition of atpC, atpA, and part of atpB from S. pneumoniae and that the intermediate OPT susceptibility of S. mitis 1174/97 correlates with the amino acid composition of its a subunit.
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Ventura, Marco, Carlos Canchaya, Douwe van Sinderen, Gerald F. Fitzgerald, and Ralf Zink. "Bifidobacterium lactis DSM 10140: Identification of the atp (atpBEFHAGDC) Operon and Analysis of Its Genetic Structure, Characteristics, and Phylogeny." Applied and Environmental Microbiology 70, no. 5 (May 2004): 3110–21. http://dx.doi.org/10.1128/aem.70.5.3110-3121.2004.

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ABSTRACT The atp operon is highly conserved among eubacteria, and it has been considered a molecular marker as an alternative to the 16S rRNA gene. PCR primers were designed from the consensus sequences of the atpD gene to amplify partial atpD sequences from 12 Bifidobacterium species and nine Lactobacillus species. All PCR products were sequenced and aligned with other atpD sequences retrieved from public databases. Genes encoding the subunits of the F1F0-ATPase of Bifidobacterium lactis DSM 10140 (atpBEFHAGDC) were cloned and sequenced. The deduced amino acid sequences of these subunits showed significant homology with the sequences of other organisms. We identified specific sequence signatures for the genus Bifidobacterium and for the closely related taxa Bifidobacterium lactis and Bifidobacterium animalis and Lactobacillus gasseri and Lactobacillus johnsonii, which could provide an alternative to current methods for identification of lactic acid bacterial species. Northern blot analysis showed that there was a transcript at approximately 7.3 kb, which corresponded to the size of the atp operon, and a transcript at 4.5 kb, which corresponded to the atpC, atpD, atpG, and atpA genes. The transcription initiation sites of these two mRNAs were mapped by primer extension, and the results revealed no consensus promoter sequences. Phylogenetic analysis of the atpD genes demonstrated that the Lactobacillus atpD gene clustered with the genera Listeria, Lactococcus, Streptococcus, and Enterococcus and that the higher G+C content and highly biased codon usage with respect to the genome average support the hypothesis that there was probably horizontal gene transfer. The acid inducibility of the atp operon of B. lactis DSM 10140 was verified by slot blot hybridization by using RNA isolated from acid-treated cultures of B. lactis DSM 10140. The rapid increase in the level of atp operon transcripts upon exposure to low pH suggested that the ATPase complex of B. lactis DSM 10140 was regulated at the level of transcription and not at the enzyme assembly step.
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Qi, Xiangying, Kaiqi Wang, Liping Yang, Zhenshan Deng, and Zhihong Sun. "The complete mitogenome sequence of the coral lily (Lilium pumilum) and the Lanzhou lily (Lilium davidii) in China." Open Life Sciences 15, no. 1 (December 31, 2020): 1060–67. http://dx.doi.org/10.1515/biol-2020-0102.

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AbstractBackgroundThe mitogenomes of higher plants are conserved. This study was performed to complete the mitogenome of two China Lilium species (Lilium pumilum Redouté and Lilium davidii var. unicolor (Hoog) cotton).MethodsGenomic DNA was separately extracted from the leaves of L. pumilum and L. davidii in triplicate and used for sequencing. The mitogenome of Allium cepa was used as a reference. Genome assembly, annotation and phylogenetic tree were analyzed.ResultsThe mitogenome of L. pumilum and L. davidii was 988,986 bp and 924,401 bp in length, respectively. There were 22 core protein-coding genes (including atp1, atp4, atp6, atp9, ccmB, ccmC, ccmFc, ccmFN1, ccmFN2, cob, cox3, matR, mttB, nad1, nad2, nad3, nad4, nad4L, nad5, nad6, nad7 and nad9), one open reading frame and one ribosomal protein-coding gene (rps12) in the mitogenomes. Compared with the A. cepa mitogenome, the coding sequence of the 24 genes and intergenic spacers in L. pumilum and L. davidii mitogenome contained 1,621 and 1,617 variable sites, respectively. In the phylogenetic tree, L. pumilum and L. davidii were distinct from A. cepa (NC_030100).ConclusionsL. pumilum and L. davidii mitogenomes have far distances from other plants. This study provided additional information on the species resources of China Lilium.
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Dissertations / Theses on the topic "ATPL"

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Šebesta, Jakub. "Strategie a koncepce leteckých dopravců pro nábor zaměstnanců na pozici pilot." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2015. http://www.nusl.cz/ntk/nusl-232003.

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This master´s thesis provides an overview of diferences between conventional way to obtain ATPL licence and MPL course. Next focus is on the flight schools providing this courses and air carriers requirements to their future pilots.
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Drager, Robert Gray. "Structure and transcript processing of a Euglena gracilis chloroplast operon encoding genes rps2, atpI, atpH, atpF, atpA and rps18." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186334.

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A 9.8 kbp region of the Euglena gracilis chloroplast genome has been cloned, sequenced and analyzed. This region contains six genes, rps2, rps18, atpI, atpH, atpF and atpA which encode ribosomal proteins S2 and S18 and ATP synthase subunits CFₒIV, CFₒIII, CFₒI and CF₁α, respectively. The linear order of these genes, 5'-rps2-atpI-atpH-atpF-atpA-rps18-3', is similar to that of land plant chloroplasts. These six genes are co-transcribed with two tRNA genes which are 5' to rps2. A fully spliced, 5.5 kb transcript containing all six genes accumulates. The spliced hexa-cistronic transcript is processed by intercistronic cleavage to mono-cistronic mRNAs. The 5' ends of the accumulated mono-cistronic transcripts map to single-stranded regions of the most stable secondary structure for each intercistronic sequence. There is no evidence for initiation of transcription in this region of the Euglena gracilis chloroplast genome. This Euglena chloroplast operon is interrupted by 17 introns. Nine of the introns are group III and seven are group II. All of the group III introns have potential secondary structures near their 3' ends which resemble domain VI of group II introns. The remaining intron is a complex twintron excised as four group III introns. This intron is comprised of two group III introns within the internal intron of a group III twintron. Two of the internal introns are excised from multiple splice sites. Two of the internal introns interrupt the domain VI-like structure of the host group III intron. The 16S rRNA sequence of Euglena chloroplasts is phylogenetically related to the 16S rRNA sequence of chromophyte chloroplasts, while the Euglena derived atpA amino acid sequence is more closely related to atpA sequences of chlorophyte chloroplasts than to atpA sequences of chromophyte chloroplasts. Too few chloroplast ribosomal protein sequences are available in the databases to perform meaningful phylogenetic analysis of rps2 or rps18. Although clustering of rps2 with the ATP synthase genes in chloroplasts of chlorophytes, rhodophytes, chromophytes and euglenophytes, but not prokaryotes, is evidence that chloroplasts are of mono-phyletic origin.
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Guelin, Emmanuel. "L'ATP synthase mitochondriale de levure : clonage et séquençage des gènes mitochondriaux ATP6 et ATP8. Clonage, séquençage et délétion du gène nucléaire ATP-E." Bordeaux 2, 1992. http://www.theses.fr/1992BOR28205.

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Su, Xin. "Yeast models of diseases linked to the mitochondrial ATP6 gene : molecular bases and therapeutic prospects." Thesis, Bordeaux, 2020. http://www.theses.fr/2020BORD0216.

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Par définition, les maladies mitochondriales résultent d’un défaut dans le processus des oxydations phosphorylantes (OXPHOS). Celui-ci permet aux cellules de se fournir en ATP, soit la principale source d’énergie qu’elles peuvent utiliser. Dans ce processus, quatre complexes (I-IV) insérés dans la membrane mitochondriale interne transfèrent à l’oxygène moléculaire les équivalents réducteurs libérés par l’oxydation de carbohydrates et d’acides gras. Cette activité génère une force proton motrice utilisée pour la synthèse d’ATP à partir d’ADP et de phosphate inorganique par le complexe V ou ATP synthase.Des maladies dont NARP (Neuropathy Ataxia Retinitis Pigmentosa) et MILS (Maternally Inherited Leigh Syndrome) ont été associées à des mutations de la sous-unité a de l’ATP synthase. Son gène (ATP6) est dans le génome mitochondrial. Celui-ci est présent jusqu’à plusieurs milliers de copies par cellule. Les mutations du gène ATP6 coexistent souvent avec des copies sauvages du génome mitochondrial dans les cellules et tissus des patients, ce qui rend leur étude difficile. La levure Saccharomyces cerevisiae dont on peut modifier à loisir le génome mitochondrial permet de s’affranchir de cette hétérogénéité génétique (appelée hétéroplasmie). De plus, grâce à sa bonne capacité fermentaire, elle est capable de survivre à l’inactivation du système OXPHOS.J’ai au cours de ma thèse exploité ces caractéristiques pour mieux définir les conséquences sur l’ATP synthase de cinq mutations du gène ATP6 identifiées chez des patients : m.8993T>G, m.9191T>C, m.8969G>A, m.8909T>C, et m.9166T>C. Le pouvoir pathogène des trois premières a été établi. Les deux dernières sont des nouveaux variants de l’ADN mitochondrial. Via l’identification de suppresseurs intragéniques, et à la lumière de structures à haute résolution de l’ATP synthase décrites récemment, j’ai pu définir les bases moléculaires des mécanismes pathogènes induits par les mutations m.8993T>G, m.9191T>C, et m.8969G>A. Le variant m.8909T>C a été identifié en combinaison avec une mutation pathogène bien connue dans un ARN de transfert (m.3243A>G). Nous avons trouvé qu’un équivalent de cette nouvelle mutation a en levure des effets délétères sur l’assemblage ou la stabilité de la sous-unité a comparables à ceux induits par des mutations du gène ATP6 (m.8993T>C, m.9176T>C) dont le pouvoir pathogène a été établi, et qu’elle a donc potentiellement la capacité d’affecter seule la santé humaine. Mes études en levure sont cohérentes avec des études ayant conclu récemment à la pathogénicité du variant m.9166T>C et permettent de mieux comprendre comment il impacte l’ATP synthase.J’ai identifié un mécanisme de suppression actif sur des modèles levure de mutations pathogènes de la sous-unité a. Il implique le transporteur des oxodicarboxylates (Odc1) localisé dans la membrane mitochondriale interne. J’ai trouvé que la surexpression d’Odc1 permet une plus grande activité du cycle de Krebs (ou TCA). Ce cycle intervient dans l’oxydation de substrats organiques dont les équivalents réducteurs sont ensuite transférés à l’oxygène par la chaîne respiratoire. Il tourne à bas régime dans les mutants de l’ATP synthase dont l’activité canal à protons est altérée. La suppression-Odc1 dépendante entraîne un découplage partiel de la membrane interne, de sorte que le cycle TCA est stimulé malgré le défaut en ATP synthase. Cet effet permet une plus grande production d’ATP via la phosphorylation d’ADP couplée directement à une des réactions du cycle de Krebs. Ces résultats ouvrent des perspectives intéressantes pour le traitement des maladies associées à des altérations de l’ATP synthase, et possiblement d’autres désordres métaboliques. Cette étude apporte de plus un éclairage nouveau sur le contrôle de la biogenèse du complexe IV par l’ATP synthase
By definition, mitochondrial diseases result from a defect in the process of oxidative phosphorylation (OXPHOS). This is responsible for the production of ATP, the main source of cellular energy. In this process, four multiprotein complexes (I-IV) inserted into the inner mitochondrial membrane transfer to molecular oxygen the reducing equivalents released by the oxidation of carbohydrates and fatty acids. This activity generates a proton motive force used for the synthesis of ATP from ADP and inorganic phosphate by the Complex V or ATP synthase.Diseases including NARP (Neuropathy Ataxia Retinitis Pigmentosa) and MILS (Maternally Inherited Leigh Syndrome) have been associated with mutations in the subunit a of ATP synthase. Its gene (ATP6) is in the mitochondrial genome. This genome is present in up to several thousand copies per cell. Mutations in the ATP6 gene often coexist with wild-type copies of the mitochondrial genome in patients' cells and tissues (heteroplasmy), which makes their study difficult. The yeast Saccharomyces cerevisiae, whose mitochondrial genome can be modified at will, makes it possible to overcome this genetic heterogeneity owing to its incapacity to stably maintaining heteroplasmy. In addition, thanks to its good fermentation capacity, this organism is able to survive mutations that inactivate the OXPHOS system.During my thesis, I exploited these characteristics to better define the consequences on ATP synthase of five ATP6 gene mutations identified in patients: m.8969G>A, m.9191T>C, m.8993T>G, m.8909T>C, and m.9166T>C. The pathogenicity of the first three has been established. The last two are new mitochondrial DNA variants. Through the identification of intragenic suppressors, and in the light of high-resolution structures of ATP synthase described recently, I was able to define the molecular bases of the pathogenic mechanisms induced by the m.8993T>G, m.9191T>C and m.8969G>A mutations. The m.8909T>C variant was identified in combination with a well-known pathogenic mutation in tRNALeu (m.3243A>G). We have found that an equivalent of this new mutation in yeast has deleterious effects on the assembly/stability of the subunit a comparable to those induced by mutations of the ATP6 gene (m.8993T>C, m.9176T>C) with a well-established pathogenicity, and therefore has the potential to affect human health on its own. My studies in yeast are consistent with studies that recently concluded on the pathogenicity of the m.9166T>C variant and allow to better understand how it impacts ATP synthase.I have identified an active suppressor mechanism in yeast models of pathogenic subunit a mutations. It involves the oxodicarboxylate transporter (Odc1) located in the inner mitochondrial membrane. I have found that artificially overexpressing Odc1 allows for greater Krebs cycle (or TCA) activity. This cycle is involved in the oxidation of organic substrates whose reducing equivalents are then transferred to oxygen by the respiratory chain. It runs low in ATP synthase mutants with impaired proton channel activity. The Odc1-dependent suppressor activity results from a partial uncoupling of the inner membrane so that the TCA cycle is stimulated despite the presence of defect in ATP synthase. This effect allows a greater production of ATP via ADP phosphorylation coupled with one of the reactions of the Krebs cycle. These results open interesting perspectives for the treatment of diseases associated with alterations in ATP synthase, and possibly other metabolic disorders. This study also sheds new light on the control of complex IV biogenesis by ATP synthase
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RIMBAULT, BLANDINE. "Etude de l'expression des genes chloroplastiques atpa et atpb, codant pour les sous unites et de l'atp synthetase, dans l'algue verte c. Reinhardtii." Paris 11, 2001. http://www.theses.fr/2001PA112043.

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L'origine endosymbiotique des chloroplastes se manifeste par le transfert de nombreux genes, a partir de l'ancetre procaryote, dans le genome nucleaire. L'existence, pour chaque complexe de l'appareil photosynthetique, de sous unites codees par le genome nucleaire et d'autres codees par le chloroplaste implique une regulation de l'expression des genes, afin que les sous unites soient produites dans les proportions requises pour leur assemblage. Les travaux presentes dans notre these concernent la regulation de l'expression de deux genes chloroplastiques de l'algue verte c. Reinhardtii, atpa et atpb, codant pour les sous unites et du complexe de l'atp synthetase. La majeure partie des genes chloroplastiques sont transcrits separement et de maniere independante. Le gene atpa fait cependant partie d'une des rares unites de transcription qui comprend trois autres genes : psbl cema et atph. Huit transcrits sont accumules. Le gene atpa occupe une position privilegiee, en tant que gene situe le plus en amont de l'unite de transcription. L'efficacite de sa traduction ne depend ni de la nature, mono ou polycistronique des transcrits contenant la phase codante de atpa, ni de leur accumulation. Le gene atpb est plus representatif de l'ensemble des genes demeures dans le chloroplaste. Un facteur nucleaire specifique, mdb1p, agit au niveau de la stabilite du transcrit. Ce facteur agit en stabilisant le transcrit, peut-etre en le rendant competent pour la traduction. Le transcrit subit de plus une maturation de la region 5 qui depend de la nature, chloroplastique ou bacterienne, de sa phase codante. Meme si le transcrit atpb possede trois codons d'initiation possibles, la traduction s'effectue a partir d'un seul aug : c'est uniquement la position du codon qui determine la traduction. Enfin nous avons mis en evidence que la traduction de atpa et atpb est coordonnee en fonction de l'assemblage de l'enzyme. L'absence d'une sous-unite du couple perturbe la synthese de l'autre sous unite: nous avons montre que des intermediaires dans la voie de biogenese de l'atp synthetase regulent negativement la synthese des deux sous unites.
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Breuil, Norman. "Conséquences de dysfonctionnements mitochondriaux chez le nématode Caenorhabditis elegans : étude de trois gènes nucléaire ant-1.1, osgl-1 et atp-9." Paris 11, 2009. http://www.theses.fr/2009PA112363.

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Les maladies mitochondriales sont des pathologies qui se traduisent par des dysfonctionnements neuromusculaires graves. Au niveau moléculaire, ces mutations affectent in fine le fonctionnement de la chaîne respiratoire, la structure du réseau mitochondrial et la stabilité du génome mitochondrial. Une meilleure compréhension de la physiopathologie sous-jacente à ces maladies nécessite le développement de modèles expérimentaux. Le nématode Caenorhabditis elegans a été choisi comme organisme modèle pour étudier certaines de ces pathologies. La famille de gènes nucléaires codant pour le transporteur mitochondrial de nucléotides adényliques, dont des dysfonctions sont à l'origine de l'ophtalmoplégie externe progressive, a été caractérisée chez le nématode. Les résultats établis ont permis l'obtention de souches transgéniques exprimant certains allèles mutants de l'homologue humain. Nous avons par ailleurs cherché à identifier le rôle joué par la protéine universelle OSGL-1 dans la physiologie mitochondriale. Nos résultats indiquent que cette protéine est impliquée dans la stabilité du génome mitochondrial. Ce gène pourrait donc constituer un nouveau gène-candidat pour les maladies associées à des altérations du génome mitochondrial. Enfin, une souche présentant une mutation dominante du gène nucléaire atp-9, codant pour l'une des sous-unités du complexe V de la chaîne respiratoire, a pu être isolée. Ce mutant récapitule la plupart des phénotypes observés chez des patients présentant des défauts du complexe V, et constitue donc un nouveau modèle d'étude pour les pathologies associées à un dysfonctionnement de l'ATP synthétase
Mitochondrial diseases result in alterations of neuromuscular functions. At the molecular level these changes affect in fine the mitochondrial respiratory chain, the mitochondrial network and the mitochondrial genome stability. A better understanding of the mechanisms underlying the physiopathology of these diseases requires the development of novel animal experimental models. The nematode Caenorhabditis elegans was used as a model organism to elucidate the mechanistic bases of some of these pathologies and to provide new animal model for these human diseases. The family of nuclear genes encoding the mitochondrial adenine nucleotide translocator, whose dysfunctions could cause the progressive external ophthalmoplegia has been functionally characterized in the nematode. Results obtained allowed us to generate transgenic C. Elegans strains expressing mutant alleles of the human homologue. We also explored the role of the universal protein OSGL-1 in the mitochondrial physiology. Our results indicate that this protein is involved in mitochondrial genome stability and could therefore be a new candidate gene for human diseases associated with alterations of the mitochondrial genome. Finally, a C. Elegans strain with a dominant mutation in the nuclear gene atp-9 encoding a subunit of the respiratory chain complex V, has been isolated. This mutant summarizes most of the phenotypes observed in patients with mitochondrial disorders (alteration of mitochondrial network, increased oxidative stress and apoptosis) and could therefore, constitute a novel model to study diseases associated with ATP synthase deficiency
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Duong, Khanh Viet. "On Enhancing Deterministic Sequential ATPG." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/31283.

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This thesis presents four different techniques for improving the average-case performance of deterministic sequential circuit Automatic Test Patterns Generators (ATPG). Three techniques make use of information gathered during test generation to help identify more unjustifiable states with higher percentage of â donâ t careâ value. An approach for reducing the search space of the ATPG was introduced. The technique can significantly reduce the size of the search space but cannot ensure the completeness of the search. Results on ISCASâ 85 benchmark circuits show that all of the proposed techniques allow for better fault detection in shorter amounts of time. These techniques, when used together, produced test vectors with high fault coverages. Also investigated in this thesis is the Decision Inversion Problem which threatens the completeness of ATPG tools such as HITEC or ATOMS. We propose a technique which can eliminate this problem by forcing the ATPG to consider search space with certain flip-flops untouched. Results show that our technique eliminated the decision inversion problem, ensuring the soundness of the search algorithm under the 9-valued logic model.
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Finegan, Brian H., and Gary Singer. "ADVANCED TELEMETRY PROCESSING SYSTEM (ATPS)." International Foundation for Telemetering, 1994. http://hdl.handle.net/10150/608547.

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International Telemetering Conference Proceedings / October 17-20, 1994 / Town & Country Hotel and Conference Center, San Diego, California
The Advanced Telemetry Processing System (ATPS) is the result of a joint development project between Harris Corporation and Veda Systems, Incorporated. The mission of the development team was to produce a high-performance, cost-effective, supportable telemetry system; one that would utilize commercial-off-the-shelf (COTS) hardware and software, thereby eliminating costly customization typically required for range and telemetry applications. A critical element in the 'cost-effective, supportable' equation was the ability to easily incorporate system performance upgrades as well as future hardware and software technology advancements. The ATPS combines advanced hardware and software technology that includes a high-speed, top-down data management environment; a mature man-machine interface; a B1-level Trusted operating system and network; and stringent real-time multiprocessing capabilities into a single, fully integrated, 'open' platform. In addition, the system incorporates a unique direct memory transfer feature that allows incoming data to pass directly into local memory space where it can be displayed and analyzed, thereby reducing I/O bottleneck and freeing processors for other specialized tasks.
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Harrington, R. A. "Evolution of ATP synthase." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603734.

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The hypothesis of modular evolution of the atp operon is re-evaluated by conducting a phylogenetic analysis of the atp operons and constituent genes of all fully sequenced genomes. Although the original hypothesis of modular evolution cannot be conclusively supported, a number of novel observations are made. Foremost is that the atp operon is a mosaic operon, a result of extensive horizontal transfer. In addition, two independent duplication events are proposed for subunits b/b’ of the enzyme, the transmembrane subunits I and z are shown to be more prevalent than previously thought, and an α/β gene pair is proposed as a putative ancestral gene duplication for these catalytic subunits. Further studies investigate the evolution and current importance of the P-loop domain, the nucleotide binding domain found with the α and β subunits of ATP synthase. A database has been developed to annotate the structure-function relationships of protein structural domains on a large-scale basis, including a novel facility to describe these relationships in terms of their taxonomic distribution. It is used in conjunction with the previously created PSIMAP structural interaction database and taxonomy databases to describe the P-loop as consistently one of the most diverse domains in the proteome. It is also represented by nodes at critical positions within both the structural interaction network, and a novel protein structure-function bipartite network, which supports the proposal that it is among the oldest and most successful of all domains. The final chapter presents case studies of three P-loop families, and explains the diversity of function, interaction partners and taxonomic distribution exhibited in terms of their structures and sequences. In particular a novel study comparing and contrasting the pore structures of all P-loop rings is presented, and partially conserved motifs in the G-proteins are described to explain their interactivity.
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Sheldon, Jonathan Gary. "Control of ATP turnover." Thesis, University of Cambridge, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627507.

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Books on the topic "ATPL"

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Desbenoit, Jean-Pierre. Circulation aérienne: [module] 010 : JAR-FCL, CPL-IR-ATPL. 5th ed. Rungis (43 rue de la Grosse-Pierre, Silic 444, 94593 Cedex): Institut aéronautique Jean Mermoz, 2003.

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Daw, Prasanta. Atul Bose. Calcutta: Indian Society of Oriental Art, 1990.

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Dodiya, Atul. Atul Dodiya. New York, NY: Bose Pacia Mo̲dern, 2003.

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Mishra, Ram Prasad. Mister Atal. Delhi: Mittal Book Agency, 2001.

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Niz̤āmī, Asad Allāh. Millī atal. Kābul: Shahīd Masʻūd Bunyād, 2008.

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Gallery, Vadehra Art, ed. Atul Dodiya. New Delhi: Vadehra Art Gallery, 2013.

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Atul Bhalla. Noida: Anant Art, 2007.

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González, Manuel Lourenzo. Atl. Vigo: Edición Xerais de Galicia, 2012.

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Da qalam atal. Koṭah: Da Ghaznawī Khprandwiye ṬolanayTakhnīkī Ṡāngah, 2008.

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Sibai, Yousuf al. Bayna al-atal. Cairo: Maktaba-e-Misr, 1994.

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Book chapters on the topic "ATPL"

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Scharnagl, Hubert, Winfried März, Markus Böhm, Thomas A. Luger, Federico Fracassi, Alessia Diana, Thomas Frieling, et al. "ATLL." In Encyclopedia of Molecular Mechanisms of Disease, 173. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-540-29676-8_8449.

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Kunz, Wolfgang, and Dominik Stoffel. "Combinational ATPG." In Reasoning in Boolean Networks, 17–47. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4757-2572-8_2.

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Harter, Thomas D. "Atul Gawande." In Contemporary Physician-Authors, 80–94. London: Routledge, 2021. http://dx.doi.org/10.4324/9781003079712-8.

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Olson, Fredrik, Mikael Brosché, Niamh Roche, and Åke Strid. "Search for the atp Operon URF6 Gene in Rhodobacter sphaeroides and Paracoccus denitrificans and Partial Sequencing of the Corresponding atpD and atpG Genes." In Photosynthesis: Mechanisms and Effects, 1731–34. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-3953-3_405.

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Harding, Aidan, Mark Ryan, and Pierre-Yves Schobbens. "Approximating ATL* in ATL." In Lecture Notes in Computer Science, 289–301. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-47813-2_20.

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Miyakawa, Shin. "ATP." In Encyclopedia of Astrobiology, 123. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_134.

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Salthe, Stanley N. "ATP." In Encyclopedia of Sciences and Religions, 161–62. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-1-4020-8265-8_201124.

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Miyakawa, Shin. "ATP." In Encyclopedia of Astrobiology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_134-2.

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Bährle-Rapp, Marina. "ATP." In Springer Lexikon Kosmetik und Körperpflege, 50. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-71095-0_876.

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Karow, Julia. "ATP." In Biochemie 2, 17–19. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-55064-9_5.

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Conference papers on the topic "ATPL"

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Petríková, Michaela, and František Jůn. "Implementation of SMS into theoretical and practical MCC training." In Práce a štúdie. University of Zilina, 2021. http://dx.doi.org/10.26552/pas.z.2021.2.33.

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The main goal of my paper is to implement safety management system into theoretical and practical MCC training. I was inspired for finishing this paper by my own integrated ATPL training at University of Žilina. Work is divided into three main parts. The first part of the paper is theory of safety management system, safety in aviation, loss of control and controlled flight into terrain. Five air accidents are characterized and analyzed in the next section. This part contains air accident Air Dubnica of two aircraft L410 in Dubnica nad Váhom, Air Accident OSSR An-24 Aircraft in Košice, Aviompanija Tatarstan accident in Kazan, accident of cypriot airline Helios and Pakistan International Airlines accident in Karachi, Pakistan. In the last part of the paper is designed implementation of the safety management system into MCC training.
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Stendel, C. "Klinisches und genetisches Spektrum MT-ATP6- und MT-ATP8-assoziierter Erkrankungen." In 24. Kongress des Medizinisch-Wissenschaftlichen Beirates der Deutschen Gesellschaft für Muskelkranke (DGM) e.V. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1685016.

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Lin, Shan, Jingbin Zhang, Gang Zhou, Lin Gu, John A. Stankovic, and Tian He. "ATPC." In the 4th international conference. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1182807.1182830.

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Gorringe, Chris, Ion A. Neag, and Ron Taylor. "ATML demonstration." In 2009 IEEE AUTOTESTCON. IEEE, 2009. http://dx.doi.org/10.1109/autest.2009.5314020.

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Biere, Armin, and Wolfgang Kunz. "SAT and ATPG." In the 2002 IEEE/ACM international conference. New York, New York, USA: ACM Press, 2002. http://dx.doi.org/10.1145/774572.774687.

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"ATPC 2008 Message." In 2008 Sixth Annual IEEE International Conference on Pervasive Computing and Communications (PerCom). IEEE, 2008. http://dx.doi.org/10.1109/percom.2008.136.

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Gorringe, Chris, Teresa Lopes, and Dan Pleasant. "ATML capabilities explained." In 2007 IEEE Autotestcon. IEEE, 2007. http://dx.doi.org/10.1109/autest.2007.4374218.

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Gorringe, Chris, Mike Seavey, and Teresa Lopes. "ATML completed status." In 2009 IEEE AUTOTESTCON. IEEE, 2009. http://dx.doi.org/10.1109/autest.2009.5314023.

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Gorringe, Chris, Mike Seavey, and Teresa Lopes. "ATML completion status." In 2010 IEEE AUTOTESTCON. IEEE, 2010. http://dx.doi.org/10.1109/autest.2010.5613574.

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"ATPC 2008 Organization." In 2008 Sixth Annual IEEE International Conference on Pervasive Computing and Communications (PerCom). IEEE, 2008. http://dx.doi.org/10.1109/percom.2008.137.

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Reports on the topic "ATPL"

1

Scharlemann, E. Extending ATP to High Frequencies. Office of Scientific and Technical Information (OSTI), November 2011. http://dx.doi.org/10.2172/1107294.

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Russell, V. K. Cleanup MAC and MBA code ATP. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/10192501.

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Chekanov, S., and J. Boomsma. ATLAS note ATL-COM-PHYS-2009. Office of Scientific and Technical Information (OSTI), December 2009. http://dx.doi.org/10.2172/970380.

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McGowen, John. FINAL CLOSEOUT REPORT THE ALGAE TESTBED PUBLIC PRIVATE PARTNERSHIP - ATP3. Office of Scientific and Technical Information (OSTI), March 2019. http://dx.doi.org/10.2172/1780639.

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Ho, Winston Z., Stephen Lee, and John Weimaster. Rapid ATP-Glow for Biological Decontamination Efficacy Test. Fort Belvoir, VA: Defense Technical Information Center, April 2003. http://dx.doi.org/10.21236/ada413266.

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Huff, J., and S. Ochsner. Update Analysis Implementation (UAI) Advanced Technical Prototype (ATP). Fort Belvoir, VA: Defense Technical Information Center, April 2001. http://dx.doi.org/10.21236/ada387653.

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Gruenhagen, Jason Alan. Bioanalytical Applications of Real-Time ATP Imaging Via Bioluminescence. Office of Scientific and Technical Information (OSTI), January 2003. http://dx.doi.org/10.2172/822057.

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Montemagno, Carlo. Development of a Generator to Power ATP-Driven Molecular Motors. Office of Scientific and Technical Information (OSTI), October 2002. http://dx.doi.org/10.2172/900245.

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Chang, Connie K. N. ATP eligibility criteria for U.S. subsidiaries of foreign-owned companies:. Gaithersburg, MD: National Institute of Standards and Technology, 1998. http://dx.doi.org/10.6028/nist.ir.6099.

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Keller, C. M. ATP for the portable 500 CFM exhauster POR-006 skid D. Office of Scientific and Technical Information (OSTI), July 1997. http://dx.doi.org/10.2172/325394.

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