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Journal articles on the topic 'Atractylis gummifera'

Author: Grafiati

Published: 27 July 2024

Last updated: 31 July 2025

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1

Boumaza, Awatif, Ali Ergüç, and Hilmi Orhan. "The cytotoxic, genotoxic and mitotoxic effects of Atractylis gummifera extract in vitro." African Health Sciences 24, no. 1 (2024): 295–306. http://dx.doi.org/10.4314/ahs.v24i1.35.

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Background: The Mediterranean thistle Atractylis gummifera L. (Asteraceae; AG) has diterpenoid glucosides; atractyloside andcarboxyatractyloside that interact with mitochondrial protein adenine nucleotide translocator (ANT) and resulted in ATP inhibition.Despite its well-known toxicity, acute poisonings still occur with this plant. Although most symptoms are attributed toANT and diterpenoids interaction, in-depth investigation of the effects of AG extract on various cellular processes has not beenperformed. Objective/method: We tested in vitro induction of mitochondrial permeability transition

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2

Georgiou, M., Biol D., L. Sianidou, T. Hatzis, J. Papadatos, and A. Koutselinis. "Hepatotoxicity due to atractylis gummifera-L." Journal of Toxicology: Clinical Toxicology 26, no. 7 (1988): 487–93. http://dx.doi.org/10.3109/15563658809038564.

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3

Daniele, C., S. Dahamna, O. Firuzi, N. Sekfali, L. Saso, and G. Mazzanti. "Atractylis gummifera L. poisoning: an ethnopharmacological review." Journal of Ethnopharmacology 97, no. 2 (2005): 175–81. http://dx.doi.org/10.1016/j.jep.2004.11.025.

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4

Bouabid, Khadija, Fatima Lamchouri, Toufik Hamid, and My El Abbes Faouzi. "Inventory of poisonings and toxicological studies carried out on Atractylis gummifera L.: A review." Plant Science Today 6, no. 4 (2019): 457–64. http://dx.doi.org/10.14719/pst.2019.6.4.582.

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Atractylis gummifera L. belongs to the family Asteraceae is widely used in traditional Moroccan medicine for its therapeutic effects (diuretic, purgative, emetic, abortive), but it causes serious and fatal poisonings, hence the objective of this work is to describe the current state of intoxication caused by A. gummifera in the Mediterranean and to summarize the toxicological studies carried out on this plant. The working methodology we adopted consisted in collecting data published in Arabic, French and English in specialized articles, books and on websites. Research results showed that the C

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5

Ahid, Samir, Mina Ait El Cadi, Bouchra Meddah, and Yahia Cherrah. "Atractylis gummifera: from poisoning to the analytic methods." Annales de biologie clinique 70, no. 3 (2012): 263–68. http://dx.doi.org/10.1684/abc.2012.0699.

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6

Achour, S., N. Rhalem, S. Elfakir, et al. "Prognostic factors of Atractylis gummifera L. poisoning, Morocco." Eastern Mediterranean Health Journal 19, no. 11 (2013): 953–59. http://dx.doi.org/10.26719/2013.19.11.953.

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7

Achour, S., A. Berdai, I. Iken, A. Attari, A. Amarti, and M. Harandou. "P49: Collective poisoning by Atractylis gummifera L., Morocco." Toxicologie Analytique et Clinique 26, no. 2 (2014): S50. http://dx.doi.org/10.1016/s2352-0078(14)70110-6.

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8

Chaboud, Annie, Georgette Dellamonica, and Jean Raynaud. "Neocorymboside, a di-C-glycosylflavone from Atractylis gummifera." Phytochemistry 27, no. 7 (1988): 2360–61. http://dx.doi.org/10.1016/0031-9422(88)80165-1.

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9

Naccari, Clara, Giulia Donato, Vincenzo Naccari, Ernesto Palma, and Pietro Paolo Niutta. "Poisoning by Atractylus gummifera L. Roots in Grazing Cattle of a Sicilian Farm." Veterinary Sciences 12, no. 4 (2025): 305. https://doi.org/10.3390/vetsci12040305.

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Background: In farm animals, the main poisonings are due to the ingestion of toxic plants present in pastures, but their incidence is underestimated, even though they are responsible for serious damage to animal health and livestock production. Atractylis gummifera L. is a plant widespread in Mediterranean countries and in southern Italy that is responsible for serious and often fatal poisonings in both humans and animals. This investigation reports grazing cattle poisoning due to the ingestion of Atractylis gummifera L. roots present in a recently plowed pasture of a Sicilian farm. Methods: T

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10

Bouabid, Khadija, Fatima Lamchouri, Hamid Toufik, Mohamed Boulfia, Souad Senhaji, and My El Abbes Faouzi. "In vivo anti-diabetic effect of aqueous and methanolic macerated extracts of Atractylis gummifera." Bangladesh Journal of Pharmacology 14, no. 2 (2019): 67–73. http://dx.doi.org/10.3329/bjp.v14i2.38870.

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The anti-diabetic effect of Atractylis gummifera (plant used in traditional Moroccan medicine) has been evaluated in type 2 diabetic mice model. The mice were divided into five groups: Normal control, diabetic control, diabetic treated with aqueous macerate (500 mg/kg), diabetic treated with methanol macerate (500 mg/kg) and diabetic treated with metformin (300 mg/kg). The treatment of the mice was performed by daily gastric gavage for 5 weeks. The monitoring of the mice was carried out weekly by fasting glucose and measurement of biochemical parameters at the end of treatment. The aqueous mac

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11

Bouabid, Khadija, Fatima Lamchouri, Hamid Toufik, Karima Sayah, Yahia Cherrah, and My El Abbes Faouzi. "Phytochemical screening and in vitro evaluation of alpha amylase, alpha glucosidase and beta galactosidase inhibition by aqueous and organic Atractylis gummifera L. extracts." Plant Science Today 5, no. 3 (2018): 103–12. http://dx.doi.org/10.14719/pst.2018.5.3.393.

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Diabetes is a chronic condition which is increasingly progressing throughout the world. To treat it, several methods are used, among which is medicinal plants that still have an unknown mechanism of action. The objective of this work is to evaluate the in vitro hypoglycemic effect of the extracts of the underground part of Atractylis gummifera, a member of Asteraceae used in traditional Moroccan medicine. A phytochemical study of the aqueous extracts (decocted, infused and macerated) and organic extracts (methanol, methanol macerate, chloroformic, ethyl acetate and petroleum ether), and a phyt

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12

Zaim, Nadia, Laïla Guemouri, Driss Lamnaouer, and Abdelaziz Benjouad. "Étude de quatre cas d’intoxication par Atractylis gummifera L. au Maroc." Therapies 63, no. 1 (2008): 49–54. http://dx.doi.org/10.2515/therapie:2008008.

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13

Masri, Wafa, Abderrazek Hedhili, and Mouldi Amamou. "Intoxication par Atractylis gummifera L : à propos de deux cas cliniques." Revue Francophone des Laboratoires 2009, no. 413 (2009): 87–91. http://dx.doi.org/10.1016/s1773-035x(09)74252-2.

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14

Hmimou, Soumaia, Hinde Hami, Abderrahim Chebat, et al. "Acute Poisoning by Atractylis Gummifera L. in Morocco: a Retrospective Review." Annals of Epidemiology 27, no. 8 (2017): 534. http://dx.doi.org/10.1016/j.annepidem.2017.07.107.

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15

Mejdoub, Kenza, Imane R. Mami, Rania Belabbes, et al. "Chemical Variability of Atractylis gummifera Essential Oils at Three Developmental Stages and Investigation of Their Antioxidant, Antifungal and Insecticidal Activities." Current Bioactive Compounds 16, no. 4 (2020): 489–97. http://dx.doi.org/10.2174/1573407215666190126152112.

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Background: Atractylis gummifera is a cosmopolitan species that is particularly abundant in the Mediterranean regions. It has been used to treat many diseases, including intestinal parasites, ulcers, snakebite poisoning, hydrops and drowsiness. As part of our research program on natural compounds with biological activities, the objective of this study was to determine for the first time the chemical composition and biological activities of essential oils of Atractylis gummifera during beginning of the vegetative cycle (March), beginning of the flowering stage (April) and full bloom (May/June).

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16

Kephalas, T., F. Alikaridis, K. Pantelia, and D. Papadakis. "Production of carboxyatractyloside and atractyloside by cell suspension cultures of Atractylis gummifera." Phytochemistry 51, no. 1 (1999): 53–54. http://dx.doi.org/10.1016/s0031-9422(98)00710-9.

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17

Calmes, M., F. Crespin, C. Maillard, E. Ollivier, and G. Balansard. "High-performance liquid chromatographic determination of atractyloside and carboxyatractyloside from Atractylis gummifera L." Journal of Chromatography A 663, no. 1 (1994): 119–22. http://dx.doi.org/10.1016/0021-9673(94)80503-2.

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18

Haslan, Haszianaliza, Farihah Haji Suhaimi, and Srijit Das. "Herbal Supplements and Hepatotoxicity: A Short Review." Natural Product Communications 10, no. 10 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001035.

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Herbal products have gained popularity over the past few decades. The reasons attributed to the rise in popularity are cheaper costs, easy availability, patient compliance and fewer side effects. However, liver toxicity following consumption of herbal remedies is on the increase. Thus, there is an urgent need to understand the mechanism of action of the herbal supplements on the liver. Occasionally, herbal supplements may also interact with conventional drugs. The present review focusses on a few herbs such as Aloe barbadensis, Atractylis gummifera, Centella asiatica, Mitragyna speciosa, Morin

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19

Hami, H., A. Soulaymani, S. Skalli, A. Mokhtari, H. Sefiani, and R. Soulaymani. "Intoxication par Atractylis gummifera L. Données du centre antipoison et de pharmacovigilance du Maroc." Bulletin de la Société de pathologie exotique 104, no. 1 (2011): 53–57. http://dx.doi.org/10.1007/s13149-010-0102-8.

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20

Vallejo, J. R., D. Peral, P. Gemio, M. C. Carrasco, M. Heinrich, and M. Pardo-de-Santayana. "Atractylis gummifera and Centaurea ornata in the Province of Badajoz (Extremadura, Spain)—Ethnopharmacological importance and toxicological risk." Journal of Ethnopharmacology 126, no. 2 (2009): 366–70. http://dx.doi.org/10.1016/j.jep.2009.08.036.

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21

Bouabid, Khadija, Fatima Lamchouri, Hamid Toufik, and My El Abbes Faouzi. "Phytochemical investigation, in vitro and in vivo antioxidant properties of aqueous and organic extracts of toxic plant: Atractylis gummifera L." Journal of Ethnopharmacology 253 (May 2020): 112640. http://dx.doi.org/10.1016/j.jep.2020.112640.

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22

Ferreira, Ariston Almeida, and Tiberio Cesar Lima de Vasconcelos. "O uso irracional de plantas medicinais: uma revisão integrativa." Research, Society and Development 11, no. 8 (2022): e59711831295. http://dx.doi.org/10.33448/rsd-v11i8.31295.

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O aumento de consumidores de produtos naturais e medicinais para profilaxia e tratamento, justifica-se tanto pelo seu potencial terapêutico, quanto pela acessibilidade de custo quando comparado aos produtos industrializados. Entretanto, o uso irracional de plantas medicinais que seguem a formulação de preparos ineficientes e estocagem errônea destes vegetais, podem provocar grandes prejuízos à saúde de um indivíduo. Realizou-se uma revisão integrativa nas bases de dados da Biblioteca Virtual em Saúde, utilizando a inserção dos descritores em Ciências da Saúde “Fitoterapia” e o termo “Uso irrac

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23

Carlier, Jérémy, Ludovic Romeuf, Jérôme Guitton, et al. "A Validated Method for Quantifying Atractyloside and Carboxyatractyloside in Blood by HPLC-HRMS/MS, a Non-Fatal Case of Intoxication with Atractylis gummifera L." Journal of Analytical Toxicology 38, no. 9 (2014): 619–27. http://dx.doi.org/10.1093/jat/bku078.

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24

Eddouks, Mohamed, Mohammed Ajebli, and Morad Hebi. "New Indices for Ethnotoxicological Assessment of Medicinal Plants: Example of Tafilalet Region, Morocco." Current Drug Safety 14, no. 2 (2019): 127–39. http://dx.doi.org/10.2174/1574886314666190206184436.

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Background:Several botanical species are poisonous and are used for medicinal purposes in traditional medicine. In fact, a relationship between toxicity and phytotherapeutic potential of medicinal plants exists. Objective:Until now, there is no ethnopharmacological indices evaluating mathematically the toxic property of any medicinal plant used traditionally. Consequently, it is important to find this link through the establishment and development of novel indices that put into consideration the relationship between toxicity and phytotherapy. Two essential objectives were targeted in the prese

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25

Stickel, Felix, Gerlinde Egerer, and Helmut Karl Seitz. "Hepatotoxicity of botanicals." Public Health Nutrition 3, no. 2 (2000): 113–24. http://dx.doi.org/10.1017/s1368980000000161.

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AbstractObjectiveHepatic impairment resulting from the use of conventional drugs is widely acknowledged, but there is less awareness of the potential hepatotoxicity of herbal preparations and other botanicals, many of which are believed to be harmless and are commonly used for self-medication without supervision. The aim of this paper is to examine the evidence for hepatotoxicity of botanicals and draw conclusions regarding their pathology, safety and applications.DesignCurrent literature on the hepatotoxicity of herbal drugs and other botanicals is reviewed. The aetiology, clinical picture an

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26

Carlier, J., L. Romeuf, J. Guitton, F. Bevalot, L. Fanton, and Y. Gaillard. "O27: A validated method for quantifying atractyloside and carboxyatractyloside in blood and urine by HPLC-HRMS/MS, a non-fatal case of intoxication with Atractylis gummifera L." Toxicologie Analytique et Clinique 26, no. 2 (2014): S16—S17. http://dx.doi.org/10.1016/s2352-0078(14)70035-6.

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27

El Qabissi, Oumaima. "Hepatic Cytolysis Induced by Percutaneous Application of Atractylis Gummifera." International Journal of Clinical Studies and Medical Case Reports 28, no. 5 (2023). http://dx.doi.org/10.46998/ijcmcr.2023.28.000696.

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28

Khanfri, Leila, Aya Madi, Hafsa Hajji, Salma Naji, Salma E El Kettani, and Fadila A. Boughima. "Fatal Atractylis gummifera L. poisoning: A case report of an autopsy." Medico-Legal Journal, June 20, 2023. http://dx.doi.org/10.1177/00258172231160316.

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Atractylis gummifera L. is a wild poisonous plant found in rural areas around the Mediterranean. It is also available from herbalists. This plant has a liver tropism which can be fatal whether taken orally or transcutaneously. In this case report, we report and discuss the clinical, biological and autopsy data of one case of poisoning of a small child in Morocco with a view to raising awareness of this dangerous poisonous glue thistle especially when used transcutaneously.

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29

Benlamkaddem, Said, Yasmina Ouedghiri, Hasnae Hoummani, Mohamed Adnane Berdai, Sanae Achour, and Mustapha Harandou. "A fatal case of cutaneous “Atractylis gummifera L.” poisoning: Case report." Toxicologie Analytique et Clinique, May 2023. http://dx.doi.org/10.1016/j.toxac.2023.05.001.

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30

Nya, Samir, Hind Abouzahir, Abdellah Dami, et al. "Death in Children After Atractylis gummifera L. Poisoning in Morocco—Report of Three Cases and Review of Literature." American Journal of Forensic Medicine & Pathology Publish Ahead of Print (October 29, 2020). http://dx.doi.org/10.1097/paf.0000000000000633.

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