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Journal articles on the topic 'Atropinization'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Mohamad, Abeer, Hind Mahdi, and Majid Younis. "THE COMPARISON BETWEEN THE EFFECT OF TWO HOURS ATROPINIZATION VERSUS THREE DAYS ATROPINIZATION ON THE CYCLOPLEGIC OUTCOME IN CHILDREN." Iraqi Journal of Medical Sciences 16, no. 4 (2018): 372–77. http://dx.doi.org/10.22578/ijms.16.4.3.

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Background: Cycloplegia abolishes the accommodative power by causing paralysis of ciliary muscle by anticholinergic drugs, which will inhibit stimulation of both ciliary muscle and sphincter pupillae causing cycloplegia and mydriasis. Atropine is widely used in cycloplegic refraction despite its potential toxicity. Objective:To evaluate the possible role of two hours atropinization versus three days atropinization on the cycloplegic outcome in children. Methods: This is a clinical interventional study that included fifty children aged two to seven years' old who attended Ibn Alhaitham Teaching

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2

Auffarth, Gerd, and Wilfried Hunold. "Cycloplegic refraction in children: Single-dose-atropinization versus three-day-atropinization." Documenta Ophthalmologica 80, no. 4 (1992): 353–62. http://dx.doi.org/10.1007/bf00154384.

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3

Park, Jong-uk, Young-gi Min, Sangcheon Choi, Dong-wan Ko, and Eun Jung Park. "Assessment and Methods of Nutritional Support during Atropinization in Organophosphate and Carbamate Poisoning Cases." Journal of The Korean Society of Clinical Toxicology 18, no. 2 (2020): 123–29. http://dx.doi.org/10.22537/jksct.2020.18.2.123.

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Purpose: Atropine is an antidote used to relieve muscarinic symptoms in patients with organophosphate and carbamate poisoning. Nutritional support via the enteral nutrition (EN) route might be associated with improved clinical outcomes in critically ill patients. This study examined the administration of nutritional support in patients undergoing atropinization, including methods of supply, outcomes, and complications. Methods: A retrospective observational study was conducted in a tertiary care teaching hospital from 2010 to 2018. Forty-five patients, who were administered with atropine and o

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4

Bark, Sang U., Jeong Mi Moon, and Byeng Jo Chun. "Enteral nutrition in mechanically ventilated patients after organophosphate poisoning." Journal of The Korean Society of Clinical Toxicology 22, no. 1 (2024): 1–9. http://dx.doi.org/10.22537/jksct.2024.00001.

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Purpose: Nutritional therapy is a crucial component of therapy for critically ill patients, but there is a lack of nutritional support guidelines for organophosphate (OP) poisoning, likely due to the gastrointestinal effects of atropine, the main antidote for OP. This study investigated whether enteral nutrition (EN) during atropinization is acceptable for mechanically ventilated patients after OP poisoning.Methods: This retrospective study classified 82 patients with OP poisoning according to whether they were fed during atropinization while on mechanical ventilation (MV). Data on the baselin

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Muzaffar, Ali Shaikh Muhammad Iqbal* Mumtaz Ali Lakho Syed Jahanghir Sadia Shaikh and Hamid Nawaz Ali Memon. "CASUAL COMPARATIVE ANALYSIS OF SPEED OF INITIAL ATROPINIZATION AND RATE OF SYMPTOM RESOLUTION AMONG PATIENTS OF ACCIDENTAL ORGANOPHOSPHATE POISONING." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3445–50. https://doi.org/10.5281/zenodo.1001730.

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Objective: This study hopes to compare the rate of symptom resolution achieved with different recommended speeds of initial atropinization as part of treatment of patients presenting with accidental organophosphate insecticide poisoning. Methodology: The casual-comparative analysis was conducted at the department of medicine, Liaquat university hospital, upon a total of 117 patients from October 2016 to July 2017. Informed consent was acquired from each patient before administering each of the recommended dosage regimens. Results: The best performing regimen was administration of a beginning b

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Ninomiya, I., K. Matsukawa, T. Honda, N. Nishiura, and M. Shirai. "Cardiac sympathetic nerve activity and heart rate during coronary occlusion in awake cats." American Journal of Physiology-Heart and Circulatory Physiology 251, no. 3 (1986): H528—H537. http://dx.doi.org/10.1152/ajpheart.1986.251.3.h528.

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Responses in efferent cardiac sympathetic nerve activity (CSNA) and heart rate (HR) to a 100-s anterior descending coronary artery occlusion were measured in cats under awake, atropinized, anesthetized, or anesthetized and atropinized states. In the conscious state, at 20 and 90 s of occlusion, CSNA increased by 23% and then decreased by 7%, respectively, whereas HR decreased by 5 and 17%, respectively. With atropinization and/or anesthesia, the initial increase in CSNA was inhibited and the later decrease in CSNA was enhanced, whereas the bradycardia was diminished. HR changed in proportion t

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7

SVENNERSTEN, K., L. NELSON, and K. JUVNÄS-MOBERG. "Atropinization decreases oxytocin secretion in dairy cows." Acta Physiologica Scandinavica 145, no. 2 (1992): 193–94. http://dx.doi.org/10.1111/j.1748-1716.1992.tb09355.x.

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8

Dr., Digbijay Kumar Thakur, Rameshwar Mahaseth Dr., and SidhiDatri Jha Dr. "Predictors of Morbidities in Organophosphate Poisoning." International Journal of Innovative Science and Research Technology 7, no. 3 (2022): 878–94. https://doi.org/10.5281/zenodo.6421676.

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Organophosphate compounds are the most common pesticides with high potential for producing acute and sub-acute toxicities. As we know, debates continue over indicators of poor prognosis and mortality.we intended to observe if morbidity in terms of requirement of ventilation, complications developed, prolongation of QTc interval, derangement in liver and renal functions, hospital stay and need of ICU admission can be assessed from clinical parameters at presentation.This might enable clinicians to identify patients needing intensive monitoring and treatment. Methods: This is a cross sectional o

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9

Buckley, Nicholas A., Andrew H. Dawson, and Ian M. Whyte. "Organophosphate Poisoning: Peripheral Vascular Resistance – A Measure of Adequate Atropinization." Journal of Toxicology: Clinical Toxicology 32, no. 1 (1994): 61–68. http://dx.doi.org/10.3109/15563659409000431.

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10

Connors, Nicholas J., Zachary H. Harnett, and Robert S. Hoffman. "Comparison of Current Recommended Regimens of Atropinization in Organophosphate Poisoning." Journal of Medical Toxicology 10, no. 2 (2013): 143–47. http://dx.doi.org/10.1007/s13181-013-0324-9.

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11

Rauhofer, E. A., D. Greenberg, and G. P. Smith. "Peripheral atropinization does not change meal size controlled by prepyloric mechanisms." Physiology & Behavior 59, no. 2 (1996): 237–40. http://dx.doi.org/10.1016/0031-9384(95)02132-9.

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12

Sudhan Devkota, Sanjog Kandel, Bhawana Giri, et al. "Sigmoid Volvulus: A Rare Complication of Atropine Therapy in a Patient with Organophosphorus Poisoning: A Case Report." Journal of Universal College of Medical Sciences 12, no. 01 (2024): 65–68. http://dx.doi.org/10.3126/jucms.v12i01.65661.

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Various complications of atropine therapy in cases of organophosphorus poisoning have been reported. Among them, atropine induced paralytic ileus is a serious gastrointestinal complication with very few cases published worldwide. The tendency of over atropinization in organophosphorus poisoning despite regular monitoring is common and may develop life threatening complications as well. This necessitates knowledge, thorough examination, and an experienced approach to aid in treatment and complications management. We have discussed a case of organophosphorus poisoning, with symptoms of atropine

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13

Singh, Supriya, Bidri RC, and Veeresh Badiger. "COMPARATIVE STUDY OF COMMONLY PRACTICED ATROPINIZATION REGIMENS IN ACUTE ORGANOPHOSPHORUS COMPOUND POISONING." International Journal of Clinical and Biomedical Research 4, no. 2 (2018): 56. http://dx.doi.org/10.5455/ijcbr.2018.42.13.

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14

Sah, Arun Kumar, and Rajesh Kumar Mandal. "Prognostic Value of Serum Cholinesterase in Acute Organophosphate Poisoning." International Journal of Health Sciences and Research 12, no. 2 (2022): 125–31. http://dx.doi.org/10.52403/ijhsr.20220217.

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Background: Organophosphorus (OP) compounds are anti acetylcholinesterase, used abundantly as pesticides and often misused as poisoning agents. Irreversible inhibition of cholinesterase enzymes is attributed to the serious clinical outcomes in these patients. This study aims to identify the relationship between the serum cholinesterase (SChE) activity and outcome. Material and Methods: A descriptive cross-sectional study conducted in the Department of Internal Medicine of Bir Hospital, Kathmandu from July 2019 to December 2019. 50 patients of OP poisoning were studied. Laboratory investigation

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15

Wang, W., Q.-F. Chen, H.-L. Ruan, K. Chen, B. Chen, and J.-M. Wen. "Can anisodamine be a potential substitute for high-dose atropine in cases of organophosphate poisoning?" Human & Experimental Toxicology 33, no. 11 (2014): 1186–90. http://dx.doi.org/10.1177/0960327114532382.

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A case of organophosphate (OP) poisoning was admitted to the emergency room. The patient accepted treatment with pralidoxime (PAM), atropine, and supporting therapy. It was observed that even after 22 h after treatment, 960 mg of atropine was not enough for the patient to be atropinized. However, a 160-mg follow-up treatment of anisodamine was quite enough for atropinization after 4 h. As a case report, more studies are required before any definite conclusion can be reached regarding the use of anisodamine as a potential substitute for high-dose atropine in cases of OP poisoning.

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16

Vieira De Melo Junior, E., I. Natalia Solarte Agredo, S. B. D. Oliveira, et al. "PNS9 BUDGET IMPACT OF NEW RECOMMENDATION FOR ATROPINIZATION IN BRAZILIAN GUIDELINES FOR ANTICOLINESTARASIS INTOXICATION." Value in Health Regional Issues 19 (October 2019): S64. http://dx.doi.org/10.1016/j.vhri.2019.08.357.

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17

Whatham, Andrew R., Daniel Lunn, and Stuart J. Judge. "Effects of Monocular Atropinization on Refractive Error and Eye Growth in Infant New World Monkeys." Investigative Opthalmology & Visual Science 60, no. 7 (2019): 2623. http://dx.doi.org/10.1167/iovs.18-24490.

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18

Garcia, S. I., S. M. Dabsys, D. Santajuliana, et al. "Interaction between thyrotrophin-releasing hormone and the muscarinic cholinergic system in rat brain." Journal of Endocrinology 134, no. 2 (1992): 215–19. http://dx.doi.org/10.1677/joe.0.1340215.

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ABSTRACT TRH increases the pressor response to acetylcholine through an increment in muscarinic receptors. As chronic atropinization produces a similar effect, we hypothesized that both phenomena may be related. The effect of chronic atropine treatment on the TRH content of several brain areas in Wistar rats was studied. Atropine produced significant increases in TRH content in the preoptic and septal areas, while decreases were observed in the hypothalamus and hypophysis. The concentration of TRH in cerebrospinal fluid rose significantly in atropine-treated rats compared with controls. A simi

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19

Wang, Wei, Quan-Fang Chen, Qi-Bin Li, et al. "Efficiency of anisodamine for organophosphorus-poisoned patients when atropinization cannot be achieved with high doses of atropine." Environmental Toxicology and Pharmacology 37, no. 2 (2014): 477–81. http://dx.doi.org/10.1016/j.etap.2013.12.016.

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20

Pierzynowski, S. G., R. Zabielski, P. Podgurniak, et al. "Effects of reversible cold vagal blockade and atropinization on exocrine pancreatic function during liquid food consumption in calves." Journal of Animal Physiology and Animal Nutrition 67, no. 1-5 (1992): 268–73. http://dx.doi.org/10.1111/j.1439-0396.1992.tb00609.x.

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21

Zabielski, R., S. Kato, SG Pierzynowski, H. Mineo, P. Podgurniak, and W. Barej. "Effect of intraduodenal HCl and soybean extract on pancreatic juice secretion during atropinization and cold vagal blockade in calves." Experimental Physiology 77, no. 6 (1992): 807–17. http://dx.doi.org/10.1113/expphysiol.1992.sp003647.

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22

Allen, D. A., E. R. Schertel, S. E. Weisbrode, and P. D. Myerowitz. "Acute lung injury isolated to an in situ lung preparation causes sustained reflex cardiovascular depression in dogs." Journal of Applied Physiology 77, no. 4 (1994): 1850–57. http://dx.doi.org/10.1152/jappl.1994.77.4.1850.

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We tested the hypothesis that acute lung injury (ALI) isolated to a perfused in situ left lung preparation results in sustained reflex cardiovascular depression. Phorbol myristate acetate (PMA), an agent that activates neutrophils, administered into the isolated lung preparation of chloralose-anesthetized dogs resulted in ALI, as assessed by wet-to-dry weight ratios and histopathology, and significant decreases in heart rate (43%), mean arterial pressure (27%), aortic blood flow (29%) and maximum rate of change in left ventricular pressure (30%). Significant reflex effects occurred by 20 min a

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23

NINOMIYA, Ishio, Kanji MATSUKAWA, Toshihiro HONDA, Naoki NISHIURA, and Akihiro NABUCHI. "Effects of baroceptor reflex on cardiac and renal sympathetic nerve activity before and after atropinization in awake cats at rest." Japanese Journal of Physiology 38, no. 4 (1988): 491–506. http://dx.doi.org/10.2170/jjphysiol.38.491.

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24

Ackermann, Uwe, Julie Khanna, and Terumi G. Irizawa. "Atrial natriuretic factor alters autonomic interactions in the control of heart rate in conscious rats." Canadian Journal of Physiology and Pharmacology 66, no. 7 (1988): 930–36. http://dx.doi.org/10.1139/y88-151.

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Regulation of heart rate was studied in rats receiving either i. v. saline at 64 μL/min or synthetic 28-residue rat atrial natriuretic peptide (ANF) at a dose sufficient to decrease mean arterial blood pressure by 10%. Autonomic influences were deduced from steady-state heart rate responses of each group to propranolol, atropine, or propranolol and atropine combined. A multiplicative model of heart rate control was used to derive quantitatively from the data the modulation of intrinsic heart rate by sympathetic and parasympathetic mechanisms. Animals receiving ANF showed a lower heart rate tha

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Perera, PMS, S. Shahmy, I. Gawarammana, and AH Dawson. "Comparison of two commonly practiced atropinization regimens in acute organophosphorus and carbamate poisoning, doubling doses vs. ad hoc: a prospective observational study." Human & Experimental Toxicology 27, no. 6 (2008): 513–18. http://dx.doi.org/10.1177/0960327108091861.

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There is a wide variation and lack of evidence in current recommendations for atropine dosing schedules leading to subsequent variation in clinical practice. Therefore, we sought to examine the safety and effectiveness of a titrated vs. ad hoc atropine treatment regimen in a cohort of patients with acute cholinesterase inhibitor pesticide poisoning. A prospective cohort study was conducted in three district secondary referral hospitals in Sri Lanka using a structured data collection form that collected details of clinical symptoms and outcomes of cholinesterase inhibitor pesticide poisoning, a

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Proskurina, O. V. "STATIC STREAK SKIASCOPY (RETINOSCOPY) UNDER NATURAL CONDITIONS AND IN CYCLOPLEGIA." Russian Pediatric Ophthalmology 9, no. 1 (2014): 33–36. https://doi.org/10.17816/rpoj37567.

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This study was designed to estimate the accuracy of results obtained by static streak skiascopy. It included 58 children at the age from 5 to 18 years with refraction studied under natural conditions and 79 children at the age varying from 1 to 18 years with refraction evaluated within 3 days after atropinization. The results of static streak skiascopy were compared with the data obtained by skiascopy performed using a plane mirror or by a subjective study and autorefractometry. It was shown that the results of the measurement of sphere equivalent refraction under natural conditions and by sta

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27

Koirala, Deepak Prasad, Kalipatnam Seshagiri Rao, Kalpana K. Malla, and Tejesh Malla. "A Study of Clinical Features, Management and Outcome of Organophosphate and Carbamate Poisoning in Children." Journal of Nepal Paediatric Society 33, no. 2 (2013): 85–90. http://dx.doi.org/10.3126/jnps.v33i2.7799.

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Introduction: Organophosphates (OP) are commonly used pesticides in rural agricultural regions of Nepal and carbamates are popular household insecticides. Because of poor legislation these poisons are easily accessible and are the most popular suicidal poisons. Materials and Methods: This was a retrospective study done in poisoning cases admitted in PICU of Manipal Teaching Hospital (MTH) over a seven year period. Results: Out of 187 cases of poisoning, 30 (16.04%) were OPs and 4 (2.13%) were Carbamates. The male to female ratio was 56:44 and these poisonings were more common in rural areas (5

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Junapati, I. Kadek Ludi, and Fabianus Anugrah Pratama. "Effectiveness of Atropine Sulfate and Diazepam in Organophosphate Poisoning in Remote Area: A Case Report." Solo Journal of Anesthesi, Pain and Critical Care (SOJA) 4, no. 2 (2024): 139. http://dx.doi.org/10.20961/soja.v4i2.77914.

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<strong>Background</strong>: Organophosphate poisoning is a significant public health concern in developing countries, including Indonesia, largely due to the widespread use of pesticides and insecticides. These chemicals, while effective for agricultural purposes, have been linked to severe health issues, including acute poisoning. One of the major health risks associated with organophosphate exposure is its potential link to suicide attempts. The toxic effects of organophosphates primarily stem from their inhibition of acetylcholinesterase, an enzyme crucial for the proper functi

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Kumar Thakur, Dr Digbijay, Dr Sidhi Datri Jha, Dr Rameshwar Mahaseth, and Dr Manish Pande. "Clinical consequences of Hypotension in patient with organophosphate poisoning." International Journal of Medical Science and Clinical Invention 8, no. 12 (2021): 5858–64. http://dx.doi.org/10.18535/ijmsci/v8i12.04.

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Objective: Aim of study is to describe the clinical consequences of hypotension in patient with organophosphate poisoning. Method: In the retrospective cohort study, we analyzed data of 66 patients with organophosphate poisoning who were treated at Bir Hospital, Nams Kathmandu. Data from those with hypotension and normal blood pressure were compared to identify significant clinical consequences. Results: All together 66 patients were enrolled in this study out of which 44(66.7%) were female and 22(33.3%) were male. After analyzing data, we found 18.2% of case with severe poisoning (ACHE < 7

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Khanum, Easnem, Md Ashraful Islam, Mohammad Salim, SM Rafiqul Islam, and Md Rezaul Haque PK. "Management of OPC and Carbamate Poisoning in Intensive Care Unit of Enam Medical College & Hospital, Savar, Dhaka." Journal of Enam Medical College 8, no. 3 (2018): 144–52. http://dx.doi.org/10.3329/jemc.v8i3.38364.

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Background: Bangladesh is an agriculture-dependent country. Organophosphorus insecticides are widely used for the better outcome of cultivation. It is used for suicidal purpose due to its easy availability all over the country. Worldwide, acute pesticide poisoning is causing major health problems with high mortality in developing countries.Objective: The objective of our study was to establish that early management of acute poisoning with organophosphorus and carbamate in ICU along with ventilatory support in severe respiratory distress reduces the mortality rate.Materials and Methods: This st

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М.Р., Мадиева, Тусупжанова А.К. та Жаркимбаева А.Д. "КЛИНИЧЕСКИЙ СЛУЧАЙ: ВОЗМОЖНОСТИ РЕНТГЕНОЛОГИЧЕСКОГО МЕТОДА В ДИАГНОСТИКЕ ВРОЖДЕННОГО ГИПЕРТРОФИЧЕСКОГО ПИЛОРОСТЕНОЗА". Наука и здравоохранение, № 2(23) (30 квітня 2021): 170–75. http://dx.doi.org/10.34689/sh.2020.22.6.019.

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В данной статье представлен клинический случай врожденного гипертрофического пилоростеноза (ВГП), диагностика которого основывается на рентгенологическом методе, до сих пор являющимся «золотым стандартом» для данной патологии у детей. Этиология до сих пор до конца не изучена. По-видимому, существуют генетические, семейные и экологические факторы предрасположенности, необходимые для развития ВГП [7]. Проведенный анализ демонстрируемой истории болезни показывает тактику ведения пациентов с врожденным пилоростенозом, основанный на клинико-диагностическом наблюдении, и свидетельствует о роли рентг

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Yuksel Elgin, Cansu, Ahmet Fırat Atseven, Ofeliya Mammadzada, and Özcan Ocakoğlu. "Daratumumab-induced acute angle closure glaucoma: bone marrow transplantation as a possible risk factor and atropinization as a potential solution." BMC Ophthalmology 25, no. 1 (2025). https://doi.org/10.1186/s12886-025-04214-5.

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Abstract This case report describes a 29-year-old female with recurrent T-cell Acute Lymphoblastic Leukemia who developed acute angle closure glaucoma (AACG) following daratumumab infusion. The patient, with a history of bone marrow transplantation and head-neck radiotherapy, experienced sudden eye pain and blurred vision minutes after treatment initiation. Ophthalmological examination revealed bilateral closed angles and elevated intraocular pressure. Ultrasound biomicroscopy showed ciliary malrotation and effusion, suggesting choroidal effusion secondary to daratumumab. The condition was suc

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Ye, Changqing, Qiang Zhang, Yongsheng Chao, and Chun Yin. "Case Report: Effective Treatment for Acute Chlorpyrifos Poisoning Complicated by a Non-ST-Segment Elevation Myocardial Infarction." Frontiers in Cardiovascular Medicine 8 (April 30, 2021). http://dx.doi.org/10.3389/fcvm.2021.623708.

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Background: Acute myocardial infarction (AMI) is a rare complication of acute organophosphorus pesticide poisoning. Although chlorpyrifos has been widely used as an organophosphate insecticide, a few cases of AMI complicated by chlorpyrifos poisoning have been reported thus far. Hence, a suitable treatment strategy remains to be explored.Case Presentation: Based on the clinical manifestations, medical history, results of an auxiliary examination, and serum biomarkers, a 65-year-old male farmer with complaints of nausea, vomiting, chest tightness, and pain was clearly diagnosed as having a seve

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Kunlun, Wang, Yuan Jun, Xu Shiming, et al. "Case report: Treatment of severe phorate poisoning." Frontiers in Toxicology 7 (May 9, 2025). https://doi.org/10.3389/ftox.2025.1581362.

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BackgroundPhorate is a highly toxic organophosphorus pesticide. Owing to its low cost and insecticidal potency, it is still widely used in parts of China, resulting in cases of occupational and life poisoning. This article presents the treatment process for phorate poisoning and monitoring the toxic metabolites terminology in the body.Case reportA 23-year-old male patient ingested about 300 mL (180 g) of 60% phorate emulsion 4 h before admission at our hospital. The patient had ingested over 300 times the lethal dose. During hospitalization, the patient’s levels of cholinesterase, phorate and

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Kaymak, Hakan, Ann-Isabel Mattern, Birte Graff, et al. "Sicherheit von Brillengläsern mit DIMS-Technologie und Atropin in der Kombinationstherapie der Myopieprogresssion." Klinische Monatsblätter für Augenheilkunde, August 25, 2022. http://dx.doi.org/10.1055/a-1930-7116.

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Hintergrund: Es soll die Sicherheit im Straßenverkehr beim Tragen von Brillengläsern mit Defocus Incorporated Multiple Segments (DIMS) Technologie in der Kombination mit Atropin evaluiert werden. Patienten und Methoden: An 12 jungen Erwachsenen (Alter: 24 bis 45; 30,1 ± 5,7 Jahre) wurde der Fernvisus und die Kontrastempfindlichkeit (KE), sowie Blendempfindlichkeit bei Versorgung mit DIMS-Brillengläsern allein und in der Kombination mit 0,01% Atropin untersucht. Ergebnisse: Durch Atropineinwirkung vermindert sich der Fernvisus beim Blick durch den zentralen Bereich des DIMS-Brillenglases nicht;

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