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Dissertations / Theses on the topic 'Atypical enteropathogenic E. coli'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Junior, Afonso Gomes Abreu. "Caracterização da proteína Pic (protein involved in colonization) em Escherichia coli enteropatogênica atípica." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-10062015-160611/.

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A serinoprotease Pic é uma proteína autotransportadora que apresenta papel importante na colonização da mucosa intestinal por E. coli enteroagregativa (EAEC). Uma cepa de E. coli enteropatogênica atípicas (aEPEC) albergando o gene pic foi detectada em um estudo prévio. O presente estudo teve como objetivo caracterizar a proteína Pic produzida por essa cepa de aEPEC (BA589). O gene pic em BA589 está presente em um plasmídeo de alto peso molecular (~98 kb) e o sequenciamento desse gene mostrou identidade de 99% com pic de EAEC 042. Pic da cepa BA589 (Pic589) foi capaz de clivar mucina bovina, he

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2

Kleta, Sylvia. "Einfluss des probiotischen Escherichia coli Nissle 1917 (EcN) auf die Infektion mit atypischen enteropathogenen E. coli (aEPEC) im porcinen in vitro-Modell." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/15941.

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In der vorliegenden Arbeit wurde in einem in vitro-Modell mit porcinen intestinalen Epithelzellen (IPEC-J2) der Einfluss des probiotischen E. coli Nissle 1917 (EcN) auf die Infektion mit atypischen EPEC (aEPEC) untersucht. EcN reduzierte bei Vorinkubation auf IPEC-J2 die aEPEC-Infektion drastisch. Konfokale Laserscanning- und Elektronenmikroskopie zeigten, dass EcN die Adhäsion und Mikrokoloniebildung inhibierte, jedoch nicht die Ausbildung von Attaching and Effacing-Läsionen adhärenter aEPEC. Der inhibierende Effekt von EcN wurde durch dessen sehr gute Adhäsionsfähigkeit an IPEC-J2 vermittelt

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3

Baldwin, Thomas John. "Disease mechanism of enteropathogenic Escherichia coli." Thesis, University of Leicester, 1990. http://hdl.handle.net/2381/34445.

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Colonization of gut mucosal surfaces by enteropathogenic Escherichia coli (EPEC) elicits a severe persistant diarrhoea in infants and young children without elaboration of enterotoxins or tissue invasion. The formation of a distinct ultrastructural lesion involving intimate adherence to cell surfaces, loss of microvilli and membrane perturbations, however, has for some time been recognized as an important component of pathogenesis, but the processes involved in lesion formation and its relevance to the disease state remained obscure. In this study intimate adherence of EPEC to surfaces of cult

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4

Singh, Mona P. "Type III secretion in enteropathogenic Escherichia coli." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486563.

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Type III secretion systems (T3SS) are complex multi-component structures that are utilised in two biological contexts: translocation ofbacterial effector proteins into eukaryotic cells and flagellar protein export. The two types ofT3SS share a conserved core set ofhomologous proteins which are integrated into a larger apparatus that includes a hol1'ow filamentous surface extension, which comprises the flagellar hook and filament, or the needle and the translocation apparatus in the case of flagellar or non-flagellar systems, respectively. Enteropathogenic Escherichia coli (EPEC) and enterohaem

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5

Vanmaele, Rosa Pauline. "Role of carbohydrates in enteropathogenic Escherichia coli adherence." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0003/NQ39602.pdf.

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6

Ramamurthy, Shylaja, and Shylaja Ramamurthy. "Role of EspZ in Enteropathogenic Escherichia coli Virulence." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/623145.

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Enteropathogenic Escherichia coli (EPEC) is a leading cause of infantile diarrhea, particularly in developing countries. EPEC belongs to the attaching and effacing (A/E) family of pathogens. All A/E pathogens harbor a type III secretion system (T3SS) that delivers virulence proteins directly into host epithelial cells. These proteins mediate diverse structural and functional alterations that likely facilitate pathogenesis. We recently demonstrated that EspZ, a secreted protein unique to A/E pathogens, is a critical virulence factor and that mutant strains lacking espZ are impaired for pathogen

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7

Kaur, Sumeet. "Some aspects of biofilm formation by enteropathogenic Escherichia coli." Thesis, London Metropolitan University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595305.

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Microorganisms growing as collective communities called 'biofilms' are widely recognised today. Biofilms impact almost all aspects of human life: personal, medical and industrial. Escherichia coli are model organisms for the study of biofi lms. In this work, eight enteropathogenic E. coli (EPEe) and three Shigella sonnei strains (a bacterium that is very similar to E. coli and is often implicated in diseases that are similar to those caused by EPEe) were investigated for their biofilm fonning abilities in relation to a number of factors. These included nutrient availabi lity, pH, temperature,

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8

Law, D. "Investigation of some virulence properties of enteropathogenic Escherichia coli." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233857.

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9

Amin, Elyas Oliver Muhammad. "Investigating how enteropathogenic Escherichia coli (EPEC) subverts AKT signalling." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3653.

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The phosphoinositide 3-kinase (PI3K) signalling pathway is activated in macrophages in response to many bacterial pathogens, triggering phagocytic uptake mechanisms and phosphorylation-associated activation of the serine/threonine kinase AKT. Enteropathogenic E. coli (EPEC) inhibits both PI3K mediated phagocytosis and AKT phosphorylation; dependent on a type 3-secretion system (T3SS) critical for delivering up to 24 known effector proteins into target cells. The efficient translocation of most EPEC effectors is dependent on the T3SS effector chaperone CesT. Although the effectors and mechanism

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10

Phillips, Neil. "Mimicry of cellular signalling pathways by enteropathogenic Escherichia coli." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613949.

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11

Haigh, Richard David. "Characterisation of phosphorylation-deficient mutants of enteropathogenic Escherichia coli." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/29792.

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EPEC infection of cultured epithelial cells causes rearrangements of the cytoskeleton resulting in the effacement of microvilli and the formation of characteristic lesions involving the accretion of actin at the site of bacterial attachment. Attaching and effacing (AE) lesion formation involves the subversion of host cell signalling systems including tyrosine and serine/threonine phosphorylation of proteins, activation of phospholipase C-1, and increases in the second messengers IP3 and Ca2+. In this study the transposon TnphoaA was used to isolate EPEC mutants which were unable to induce the

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12

Wu, Gilbert Kar Po. "Signal transduction responses to enteropathogenic Escherichia coli and Shiga toxin-producing Escherichia coli infections." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0007/MQ46054.pdf.

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13

Afset, Jan Egil. "Role of enteropathogenic Escherichia coli in childhood diarrhoea in Norway." Doctoral thesis, Norwegian University of Science and Technology, Department of Laboratory Medicine, Children's and Women's Health, 2007. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-1982.

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<p><b>Background</b></p><p>Diarrhoeal diseases are among the leading causes of illness and death among children in developing countries, and do also cause considerable morbidity in industrialized countries. Enteropathogenic <i>E. coli</i> (EPEC), characterized by its ability to induce “attaching and effacing” (A/E) lesions the intestinal epithelium, is recognized as an important diarrheagenic agent in developing countries. Recently, EPEC has also been reported to be prevalent in the industrialized part of the world. Two main classes of EPEC have been recognized: typical EPEC has the ability to

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14

Snape, Susan. "The role and regulation of luxS in enteropathogenic Escherichia coli." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403460.

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15

Fletcher, Jonathan Nigel. "Plasmid-encoded virulence determinants of an enteropathogenic (0111) Escherichia coli." Thesis, University of Liverpool, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316601.

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16

Farrant, Jayne Lisa. "Molecular characterisation of the virulence determinants of enteropathogenic Escherichia coli." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385084.

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17

Smith, Katherine. "Manipulation of the host actin cytoskeleton by enteropathogenic Escherichia coli." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608524.

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18

Madkour, Azzeldin Zaid Hamed. "Studies on virulence-critical proteins of enteropathogenic Escherichia coli (EPEC)." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3942.

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Enteropathogenic Escherichia coli (EPEC) virulence depends on a Type-3 Secretion System (T3SS) that transfers many ‘effector’ proteins into human gastrointestinal cells. The components for the effector-delivery apparatus (T3SS and translocator proteins), virulence-critical surface protein (Intimin) and seven effectors (EspG, EspF, Map, EspH, EspZ, Tir, EspB; latter also a translocator) are encoded on the Locus of Enterocyte Effacement (LEE) pathogenicity island. The EspA translocator protein extends the T3SS and is tipped with EspB and EspD which insert into the plasma membrane enabling effect

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19

Roxas, Jennifer Lising, and Jennifer Lising Roxas. "Novel Virulence Strategies of Enteropathogenic Escherichia Coli: An Integrated Study." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/625671.

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Enteropathogenic Escherichia coli (EPEC) is a Gram-negative bacteria responsible for significant morbidity and mortality in young children. EPEC elaborates a type III secretion system (T3SS), which translocates bacterial effector proteins into the host intestinal epithelial cell. To this date, 23 effector proteins are known to be secreted by EPEC. Over the past two decades, traditional studies uncovered the functions of some of these effector proteins. While there was an initial rise in the EPEC effector function discoveries, we now observe a plateau in the identification of host-EPEC interact

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20

Reece, Stephen Thomas. "Functional studies of Intimin a, an adhesin of enteropathogenic Escheria Coli." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405768.

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21

Adu-Bobie, Jeanette. "Characterisation of the C-terminal domain intimin from enteropathogenic Escherichia coli." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300436.

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22

Young, Joanna. "EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits receptor tyrosine phosphorylation." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18785.

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Enterohaemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) are enteric pathogens that cause disease through intimate attachment and subversion of intestinal epithelial cells. This strategy depends on a type III secretion system (T3SS) to translocate effector proteins into host cells. EspJ is a T3SS effector protein that inhibits opsono-phagocytosis through an unidentified mechanism. This study aimed to determine the mechanism of action of EspJ through analysis of the protein itself and its effects on eukaryotic cell signalling. Bioinformatic analysis of EspJ revealed a predicted

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23

Thomassin, Jenny-Lee. "Antimicrobial peptide resistance mechanisms used by Enteropathogenic and Enterohemorrhagic «Escherichia coli»." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121462.

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Enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) are Gram-negative pathogens that cause diarrheal disease in the developed and developing world. To cause infection, these pathogens must overcome innate host defenses, such as secreted cationic antimicrobial peptides (AMPs). There are two groups of human AMPs: cathelicidins (LL-37) and defensins (α-defensin 5). AMPs are expressed in specific locations of the human body. In the small intestine, the infectious niche for EPEC, human α-defensins 5 and 6 (HD-5 and HD-6) are abundant and there are low levels of LL-37. Conversely

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24

Patel, Amit. "Interaction of enteropathogenic 'Escherichia coli' (EPEC) tir with host cell proteins." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431869.

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25

Hajj, Hussein Inaya Abdallah. "Experimental colitis and enteropathogenic E. Coli in rats : A new approach." Strasbourg 1, 2008. http://www.theses.fr/2008STR13153.

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26

Clarke, Stuart Charles. "The role of TypA in the virulence of enteropathogenic Escherichia coli." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/29789.

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Enteropathogenic Escherichia coli (EPEC) remain an important cause of diarrhoeal disease in developing countries. EPEC adhere to cultured epithelial cells in a localised pattern resulting in the effacement of microvilli and subversion of the host cell signalling pathways leading to rearrangement to the cytoskeleton. This results in the 'attaching and effacing (AE) lesion'. This project is concerned with the characterisation of a novel gene, typA (tyrosine phosphoprotein A), and its role in virulence. TypA and its flanking regions were cloned form EPEC strain E2348/69 strain E2348/69 and sequen

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27

Goosney, Danika Louise. "Enteropathogenic Escherichia coli (EPEC) interactions with the host epithelial cell actin cytoskeleton." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61095.pdf.

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28

Whale, Andrew. "Mechanism of actin pedestal formation triggered by enterohaemorrhagic and enteropathogenic escherichia coli." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445340.

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29

Creasey, Elizabeth Anne. "Protein interactions in the Type III secretion system of Enteropathogenic Escherichia Coli." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410342.

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30

Fitzhenry, Robert James. "Interactions of enteropathogenic and enterohaemorrhagic escherichia coli with intestinal mucosae in vitro." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407237.

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31

Walsham, Alistair. "Determining the protective effects of Lactobacillus reuteri against enteropathogenic Escherichia coli infection." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/62666/.

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Enteropathogenic Escherichia coli (EPEC) are non-invasive foodborne diarrhoeal pathogens that are a leading cause of infant death in the developing world. As antibiotic resistance increases amongst pathogens, new treatments are required to reduce infant mortality. Probiotic bacteria could offer a solution, and Lactobacillus reuteri have been shown to alleviate diarrhoea and reduce EPEC colonisation in clinical studies. Here, we utilised mucus and non-mucus producing human intestinal epithelial cell lines as well as human duodenal biopsies to investigate the effects of L. reuteri ATCC PTA 6475

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32

Allen, Hilary Kaye. "The Effects of Enteropathogenic and Commensal Escherichia coli on Tight Junction Permeability." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1341611861.

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33

Wong, Alexander Ray Chong. "Subversion of the host cell by enteropathogenic Escherichia coli through effector interplay." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9585.

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Enteropathogenic Escherichia coli (EPEC) strains are diarrheagenic pathogens that colonize the gut mucosa via attaching-and-effacing (A/E) lesion formation. EPEC utilize a type III secretion system (T3SS) to translocate effector proteins, including Tir and EspH that subvert host cell signalling to sustain colonization and multiplication. In vitro, EPEC induces the formation of an actin-rich ‘pseudopod’-like structure, termed pedestals. My research focussed on EspH, which is implicated in the elongation of actin pedestals, and inactivation of Rho GTPase signalling. In the first study, I showed

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34

Neves, Bianca Cruz. "Orfâ‚‚â‚‡ LEE : a possible type III secretion chaperone from enteropathogenic 'escherichia coli'." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406443.

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35

Arnold, Louise. "Characterisation of factors involved in the secretion of EspC in enteropathogenic Escherichia coli." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404785.

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36

Shaw, Robert Kenneth. "Structural and functional characterisation of the enteropathogenic Escherichia coli type III secretion systems." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274329.

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37

Chong, Yuwen. "Intimate interactions between enteropathogenic and enterohemorrhagic Escherichia coli and intestinal epithelium in vitro." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/1445194/.

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Enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC) are diarrhoeagenic human pathogens that colonize intestinal epithelial cells via an attaching and effacing (A/E) lesion. Intimate adherence is mediated through binding of the intimin adhesin to the bacterial translocated intimin receptor, Tir. EPEC adheres to all regions of the human intestine in the in vitro organ culture (IVOC) system. In contrast, although EHEC is associated with colonic pathology in human infections, a prototypical strain of EHEC has shown a restricted tropism towards follicle-associated epithel

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38

Batchelor, Miranda Jayne. "Intimate attachment of enteropathogenic escheria coli : analysis of intimin and the translocated intimin receptor." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274928.

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39

Prasannan, Sunil. "NMR structural studies of the cell-binding fragment of Intimin from enteropathogenic E. coli." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395454.

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40

Warawa, Jonathan Mark. "Role of phosphorylation in the function of the enteropathogenic Escherichia coli (EPEC) Tir molecule." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394071.

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41

Campellone, Kenneth Geno. "Actin Pedestal Formation on Mammalian Cells by Enteropathogenic Escherichia coli: A Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/95.

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Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 (EHEC) form characteristic lesions on infected mammalian cells called actin pedestals. Each of these two pathogens injects its own translocated intimin receptor (Tir) molecule into the plasma membranes of host cells. Interaction of translocated Tir with the bacterial outer membrane protein intimin is required to trigger the assembly of actin into focused pedestals beneath bound bacteria. Despite similarities between the Tir molecules and the host components that associate with pedestals, recent work indicates that E

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42

Pramanik, N. "Contribution of the inflammasome-autophagy axis in host defense to enteropathogenic Escherichia coli (EPEC)." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1467271/.

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Enteropathogenic Escherichia coli (EPEC) is a non-invasive, gram-negative bacterium that causes acute and persistent diarrhoea in infants under the age of five. Infantile diarrhoea is the second leading cause of mortality in children recorded by the World Health Organization (WHO). At present the role of innate and adaptive immunity in providing protection or mediating pathology in response to EPEC remains less well studied. Herein, multiple facets of EPEC interaction with the immune system were explored in co-cultures utilising wild-type and bacterial isogenic mutants in murine and human mode

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43

Smollett, Katherine Louise. "Characterisation of the enteropathogenic E. coli type III secretion system effector proteins ESPG and ESPG2." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439818.

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44

Kerr, Paul Gerard. "Diagnostic application of monoclonal antibodies to surface antigens of enterohaemorrhagic and enteropathogenic Escherichia coli strains." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246540.

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45

Farris, Michele Anne. "BipA : a tyrosine phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266388.

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46

Al-Layla, Aseel Abdulmunem Husse. "Investigations on how the enteropathogenic Escherichia coli (EPEC) EspF effector inhibits PI-3 kinase-dependent phagocytosis." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3959.

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Enteropathogenic E. coli inhibits phosphoinositide 3 (PI-3) kinase dependent phagocytosis via a Type Three Secretion System (T3SS) that delivers up to twenty effector proteins into target cells. The T3SS components are encoded on the Locus of Enterocyte Effacement (LEE) pathogenicity island alongside genes for a surface protein, Intimin, and seven effectors (Tir, Map, EspF, EspG, EspZ, EspH and EspB; latter also needed to deliver effectors). Inhibiting phagocytosis is linked to EspB, EspH, EspG and EspF activities with inhibitory mechanisms described for all except EspF. The aim of this study

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47

Contreras, C. A., T. J. Ochoa, J. Ruiz, et al. "Genetic diversity of locus of enterocyte effacement genes of enteropathogenic Escherichia coli isolated from Peruvian children." Society for General Microbiology, 2014. http://hdl.handle.net/10757/314308.

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The aim of this study was to determine the frequency and allele associations of locus of enterocyte effacement encoded esp and tir genes among 181 enteropathogenic Escherichia coli (EPEC) strains (90 diarrhoea-associated and 91 controls) isolated from Peruvian children under 18 months of age. We analysed espA, espB, espD and tir alleles by PCR-RFLP. EPEC strains were isolated with higher frequency from healthy controls (91/424, 21.7 %) than from diarrhoeal samples (90/936, 9.6 %) (P,0.001); 28.9% of diarrhoeal and 17.6% of control samples were typical EPEC (tEPEC). The distribution of espA all

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48

Robinson, Keith Scott. "Characterisation and identification of binding partners of non-LEE-encoded protein H of enteropathogenic E. coli." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/61897.

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Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC respectively) are human, diarrhoeal pathogens that intimately adhere to host intestinal epithelia, characterised by effacement of brush border microvilli. Both pathogens encode a filamentous type 3 secretion system that is used to deliver virulence factors, termed effectors, into the host cell. These effectors disrupt a wide range of host signalling pathways including the immune response, cytoskeleton dynamics, phagocytosis, and apoptosis. Importantly, infected cells exhibit early stage, but not late stage, features of apo

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49

Barletta, Francesca, Theresa J. Ochoa, Erik H. Mercado, et al. "Quantitative real-time polymerase chain reaction for enteropathogenic Escherichia coli: a tool for investigation of asymptomatic versus symptomatic infections." Oxford University Press, 2015. http://hdl.handle.net/10757/556075.

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theresa.j.ochoa@uth.tmc.edu<br>Article<br>BACKGROUND: Enteropathogenic Escherichia coli (EPEC) strains are pediatric pathogens commonly isolated from both healthy and sick children with diarrhea in areas of endemicity. The aim of this study was to compare the bacterial load of EPEC isolated from stool samples from children with and without diarrhea to determine whether bacterial load might be a useful tool for further study of this phenomenon. METHODS: EPEC was detected by polymerase chain reaction (PCR) of colonies isolated on MacConkey plates from 53 diarrheal and 90 healthy children aged

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50

Allen, Natalie Louise. "Identification of genomic differences between enterohaemorrhagic Escheria coli O157:H7 and a closely related strain, enteropathogenic E.coli O55." Thesis, University of Birmingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289386.

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