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Dissertations / Theses on the topic 'Autoimmune diseases'

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1

Schoonen, Wilma Marieke. "Pharmacoepidemiology of autoimmune diseases." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2007. http://researchonline.lshtm.ac.uk/4646551/.

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The current system in place to study safety of medicines after introduction on the market relies on spontaneous reporting. Adverse events occurring long after initiation or cessation of drug use are likely to be missed by this system. In this thesis we explore methods to identify signals of long-term, unexpected adverse events and methods to evaluate these signals. We utilised data from the UK General Practice Research Database (GPRD), a large primary care database. A systematic review investigating the validity of medical diagnoses recorded in this database illustrated that the GPRD is a powe
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2

Mustafa, Elwaleed Ibrahim. "Experimental autoimmune sialadenitis : studies of immunopathogenesis, cellular signaling and MHC genetics /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4791-0/.

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3

Madsen, Rasmus Kirkegaard. "Metabolic variation in autoimmune diseases." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-59475.

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The human being and other animals contain immensely complex biochemical processes that govern their function on a cellular level. It is estimated that several thousand small molecules (metabolites) are produced by various biochemical pathways in humans. Pathological processes can introduce perturbations in these biochemical pathways which can lead to changes in the amounts of some metabolites.Developments in analytical chemistry have made it possible measure a large number metabolites in a single blood sample, which gives a metabolic profile. In this thesis I have worked on establishing and un
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4

Gambelunghe, Giovanni. "Immunogenetic studies in autoimmune endocrine diseases /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-691-x/.

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5

Graaff, Wiebo Leendert van der. "T cell differentiation in autoimmune diseases." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/70775.

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6

Leeuw, Karina de. "Premature atherosclerosis in systemic autoimmune diseases." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.

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7

Pliushchyk, D. "Autoimmune diseases. How to prevent them?" Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45958.

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An autoimmune disease is a disease in which the immune system mistakenly attacks the body‘s own cells and tissues. Different body parts like digestive system, joints, nerves, blood vessels, red blood cells, connective tissues, skin and endocrine system can be affected. It‘s found that autoimmune diseases and conditions predominantly affect people during the childhood. Autoimmune disease and condition symptoms vary from individual to individual.
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8

Ning, Shunbin. "Interferon Regulatory Factors and Autoimmune Diseases." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/6542.

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9

Narayanan, Harish Anandha. "Molecular Understanding of Selected Autoimmune Diseases." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146614.

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Pathogens that affect the immune system, or defects in the immune system contribute to numerous autoimmune diseases. In this paper, we are going to review, analyze and understand recent findings in literature. The papers that are to be reviewed explore the observation of loss of regulatory T cells in individuals with multiple sclerosis, the importance of CD4+ during HIV infection, the role of CCR6 in the immune system and the importance of Pan-DR-Binding Hsp60 self-epitopes in rheumatoid arthritis. So this literary review is limited to understanding major defects in specific parts of the immun
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10

BORTOLOTTI, Daria. "HLA-G MOLECULES IN INFECTION AND AUTOIMMUNE DISEASES." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2389029.

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11

Ieronymaki, Matthaia. "Immunological and Conformational characterization of synthetic peptide probes for autoimmune diseases." Thesis, Cergy-Pontoise, 2016. http://www.theses.fr/2016CERG0831/document.

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Les maladies auto-immunes sont des maladies chroniques et hétérogènes caractérisées par des réactions du système immunitaire acquis contre les propres tissus sains de l'organisme. Ces maladies affectent presque 5% de la population mondiale et en particulier les jeunes adultes. La complexité de leur spectre est énorme et même si leur étiologie est encore incertaine, il a été démontré que des facteurs génétiques et environnementaux sont impliqués dans le déclenchement du mécanisme pathologique. Cependant, il est nécessaire d'utiliser des outils diagnostiques et / ou pronostiques fiables pour le
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12

Ye, Ping. "Autoimmunity in chronic periodontitis." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/4256.

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Profound perturbation of epithelial structure is a characteristic feature of the immunopatholoical response to bacterial antigens considered to be central in the pathogenesis of the destructive lesion of periodontitis. The pathological basis for the disturbance of epithelial structure is not understood. It was demonstrated that the structural integrity and functional differentiation of the lining epithelium is compromised in relation to inflammatory changes associated with destructive periodontitis. In the pathological lining epithelium of the periodontal pocket there was a marked reduction of
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13

Ye, Ping. "Autoimmunity in chronic periodontitis." University of Sydney, 2003. http://hdl.handle.net/2123/4256.

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Doctor of Philosophy<br>Profound perturbation of epithelial structure is a characteristic feature of the immunopatholoical response to bacterial antigens considered to be central in the pathogenesis of the destructive lesion of periodontitis. The pathological basis for the disturbance of epithelial structure is not understood. It was demonstrated that the structural integrity and functional differentiation of the lining epithelium is compromised in relation to inflammatory changes associated with destructive periodontitis. In the pathological lining epithelium of the periodontal pocket there w
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14

Wang, Chuan. "DNA Sequence Variants in Human Autoimmune Diseases." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-179189.

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Human autoimmune diseases are hallmarked by inappropriate loss-of-tolerance and self-attacking response of the immune system. Studies included in this thesis are focusing on the implication and functional impact of genetic factors in three autoimmune diseases rheumatoid arthritis (RA), asthma, and systemic lupus erythematosus (SLE). Using genetic association studies, we found in study I and II that sequence variants of the interferon regulatory factor 5 (IRF5) gene were associated with RA and asthma, and the associations were more pronounced in certain disease subtypes. Distinct association pa
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15

Emonts, M. "Polymorphisms in immune response genes in infectious diseases and autoimmune diseases." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2008. http://hdl.handle.net/1765/14316.

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16

Hall, Richard James, and n/a. "Chromosome 18 and autoimmune disease." University of Otago. Department of Biochemistry, 2005. http://adt.otago.ac.nz./public/adt-NZDU20070221.141018.

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The autoimmune diseases embody a diverse range of common human conditions that are caused by a loss of self-tolerance in the host immune system to a specific organ or tissue type. Approximately 5% of the general population are affected by autoimmune diseases which include type 1 diabetes (T1D), rheumatoid arthritis (RA) and Graves disease (GD). The majority of the autoimmune diseases are multifactorial in origin, brought about by a combination of both environmental and genetic factors. Numerous susceptibility loci have been identified for each autoimmune disease and a number of these loci have
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17

Halonen, Maria. "Monogenic model for autoimmune diseases : molecular basis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/halonen/.

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18

Prokunina, Ludmila. "Strategies for Identification of Susceptibility Genes in Complex Autoimmune Diseases." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4138.

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19

Adikari, Sanjaya Bandara. "Cytokine-modulated dendritic cell immunotherapy in autoimmune diseases /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-149-0/.

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20

Kazbay, Kasim. "Leu 1+B cells in autoimmune human diseases." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55681.

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21

Gupta, Yask [Verfasser]. "Systems genetics in polygenic autoimmune diseases / Yask Gupta." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2016. http://d-nb.info/1117169758/34.

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22

Motwani, Mona. "Cytosolic DNA sensing in autoimmune and autoinflammatory diseases." eScholarship@UMMS, 2020. https://escholarship.umassmed.edu/gsbs_diss/1074.

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Cytosolic DNA sensing plays a key role in autoimmune and autoinflammatory diseases. STING is a cytosolic adaptor protein which upon activation leads to induction of type I interferons and inflammatory cytokines. Recently, gain-of-function mutations in STING have been identified in patients with an autoinflammatory disease called STING-associated vasculopathy with onset in infancy (SAVI). We compared two independent SAVI mutant mouse models and revealed a hierarchy of immune abnormalities which were dependent on SAVI mutation in lymphocytes. We also showed that bone marrow from the V154M mutant
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23

Massey, Jonathan Peter. "Mapping the genes for complex canine autoimmune diseases." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/mapping-the-genes-for-complex-canine-autoimmune-diseases(5ea87f15-cfd6-4764-87b4-287cff05ed96).html.

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The aetiology of autoimmune disease is a complex interplay between genetics, environment and immunological regulation. Our understanding of the genetic aspects of autoimmunity has increased with recent findings from Genome Wide Association Studies (GWAS). There is now a movement towards meta-analyses of GWA studies in order to increase the number of genetic loci detected. There are also efforts to detect common genetic risk factors amongst groups of diseases that potentially share common aetiopathogenic pathways. Animal models have formed the basis of many genetic discoveries and the domestic
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24

Lee, Youjin. "Pathogenic Potential ofCD4 T Cells in Autoimmune Diseases." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17465319.

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The molecular mechanisms governing T helper (Th) cell differentiation and function have revealed a complex network of transcriptional and protein regulators. Cytokines not only initiate the differentiation of CD4 T helper into subsets, but also influence the identity, plasticity and effector function of a T cell. Th17 cells, named for producing interleukin 17 (IL-17) as their signature cytokine, secrete a cohort of other cytokines including IL-22, IL-21, IL-10, IL-9, IFNγ, and GM-CSF. In recent years, Th17 cells have emerged as a key player in host defense against both extracellular pathogen
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25

Minas, Konstantinos. "New approaches to autoimmune therapy through gene analysis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted no access until May 19, 2011. Online version available for University member only until May 19, 2012, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25620.

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26

Lövgren, Tanja. "Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases." Doctoral thesis, Uppsala University, Department of Medical Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7181.

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<p>Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. The IFN-α is a type I IFN, a family of cytokines counteracting especially viral infections, by acting directly on infected cells, and via many immunomodulatory effects. The latter may also contri
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27

Lövgren, Tanja. "Endogenous type I interferon inducers in systemic autoimmune diseases /." Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7181.

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28

Dahlman, Ingrid. "Genetic dissection of experimental autoimmune neuroinflammatory diseases in rats /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3768-0/.

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29

Almeida, Rita Alexandra Silva de. "Autoimmune blistering diseases: bullous Pemphigold, Pemphigus vulgaris and follaceus." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/22358.

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Mestrado em Biologia Molecular e Celular<br>Bullous pemphigoid and pemphigus belong to a group of autoimmune blistering diseases that attacks the body healthy tissue, causing blisters and erosions on the skin. Bullous pemphigoid is characterized by an attack to the basal keratinocytes, making them to lose adhesion to the basement membrane zone, whereas in pemphigus happens that keratinocytes in epidermis and mucous membranes lose cell-to-cell adhesion. A single mouse click on the topic pemphigus in PubMed reveals more than 9 000 articles providing one or the other information about this group
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30

Dumoitier, Nicolas. "Analysis of B lymphocytes in systemic autoimmune vascular diseases." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC304.

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Différents mécanismes de tolérance centraux et périphériques permettent la sélection négative des lymphocytes B auto-réactifs tout en préservant la sélection positive et la différenciation en plasmocytes producteurs d’anticorps de haute affinité. Ces mécanismes de tolérance sont altérés dans les pathologies auto-immunes et ces altérations conduisent à la production d’auto-anticorps. Ainsi, un ciblage thérapeutique des lymphocytes B autoréactifs, notamment avec les anticorps monoclonaux anti-CD20, donne des résultats prometteurs dans différentes pathologies auto-immunes. Si ces traitements ont
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31

TROTTA, ROSA. "A novel biomarker for cancer and autoimmune diseases: IGFBP6." Doctoral thesis, Università degli Studi di Foggia, 2019. http://hdl.handle.net/11369/382356.

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La temperatura corporea costituisce un importante meccanismo di difesa ed è il risultato di una complessa interazione che coinvolge numerosi fattori. Nell'uomo sano, la temperatura corporea è finemente regolata; deviazioni di 0.5°C oltre il limite superiore possono indicare una condizione patologica. Numerosi agenti possono indurre ipertermia, tra cui, insufficienza cardiaca acuta/cardiomiopatia acuta da stress [1] e infarto miocardico acuto [2] sindrome neurolettica maligna [3], endocrinopatie [4, 5], disturbi del sistema nervoso centrale (SNC) [6] e patologie oncologiche [7]. Le temperature
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32

Ekström, Smedby Karin. "Ultraviolet light, autoimmune disorders and the etiology of malignant lymphomas /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-313-2/.

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33

Gebre-Medhin, Gennet. "Clinical and experimental studies of organ-specific autoimmune diseases : With special reference to Addison's disease and autoimmune hepatitis : by Gennet Gebre-Medhin." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5043-1/.

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34

Mulcahy, Anthony Francis. "The molecular cloning and characterisation of autoantigens." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242453.

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35

Burfoot, Mark S. "Cloning of genes in the human major histocompatibility complex class III region by use of novel techniques." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308669.

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36

Duffy, Emeir. "An investigation of the influence of dietary supplementation of n-3 fish oil and/or copper on systemic lupus erythematosus." Thesis, University of Ulster, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273795.

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37

Caso-Pelaez, Enrique. "Analysis of the T cell receptor repertoire in autoimmune thyroid disease." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309142.

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38

O'Neill, Emma J. "An investigation of the role of interleukin-10 in the function of regulatory T cells induced by intranasal peptide administration within the context of experimental autoimmune encephalomyelitis." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274646.

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39

Chang, Thashi. "Autoimmune mechanisms underlying the stiff person syndrome." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670147.

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40

Atta, Mustafa S. "Investigation of the humoral and cellular features of autoimmune diseases." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281586.

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41

Bluvas, Peter J. (Peter Jan) 1979. "Identification of viral and bacterial triggers for human autoimmune diseases." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/87184.

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Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.<br>Includes bibliographical references (leaf 31).<br>by Peter J. Bluvas, Jr.<br>M.Eng.
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42

Imgenberg-Kreuz, Juliana. "Epigenetic and Gene Expression Signatures in Systemic Inflammatory Autoimmune Diseases." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-310388.

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Autoimmune diseases are clinical manifestations of a loss-of-tolerance of the immune system against the body’s own substances and healthy tissues. Primary Sjögren’s syndrome (pSS) and systemic lupus erythematosus (SLE) are two chronic inflammatory autoimmune diseases characterized by autoantibody production and an activated type I interferon system. Although the precise mechanisms leading to autoimmune processes are not well defined, recent studies suggest that aberrant DNA methylation and gene expression patterns may play a central role in the pathogenesis of these disorders. The aim of this
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43

Hu, Xinli. "Discovery and Functional Interpretation of Genetic Risk in Autoimmune Diseases." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467297.

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Autoimmune diseases are chronic and debilitating conditions arising from abnormal immune responses directed against normal body tissues; they collectively affect the lives of 5-10% of the world population. These diseases often show familial clustering, suggesting strong genetic heritability. For many of autoimmune diseases, variation in the human leukocyte antigen (HLA) genes is the primary modulator of genetic risk. Recently, genome-wide association studies (GWAS) identified hundreds of genomic regions outside the HLA that harbor additional risk-conferring variants. The ultimate goal is to id
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44

Maves, Lindsay. "The Role of T-lymphocyte Repertoire Selection in Autoimmune Diseases." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1249324194.

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Thesis (M.S.)--University of Toledo, 2009.<br>Typescript. "Submitted as partial fulfillment of the requirements for The Master of Science in Biology." "A thesis entitled"--at head of title. Bibliography: leaves 88-97.
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45

BUTTINI, SARA. "Genetic variations in autoimmune demyelinating diseases of the nervous system." Doctoral thesis, Università del Piemonte Orientale, 2014. http://hdl.handle.net/11579/45570.

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46

Yang, Min, and 杨敏. "Role of regulatory B cells in autoimmune disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48079832.

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Although B cells are well-known for their functions in antibody production and antigen presentation, certain B cell subsets have been recently identified as regulatory B cells to modulate immune responses through cytokine production. However, the microenvironmental factors involved in the induction of regulatory B cells remain largely uncharacterized. B cell-activating factor (BAFF), a member of TNF family cytokines produced by myeloid cells, is a key regulator for B cell maturation and function. However, it remains unknown whether BAFF plays a role in modulating the generation of regulatory
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47

Deng, Jun, and 鄧軍. "Leptin modulates T cells responses in autoimmune arthritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208601.

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Leptin, a protein hormone encoded by obese (ob) gene, is mainly produced by adipocytes. Leptin plays an important role in regulating neuroendocrine function and energy metabolism. As a cytokine, leptin is involved in modulating the hematopoiesis and lymphopoiesis. Although leptin has been found to promote T cells activation, it is largely unclear whether and how leptin regulates T cell differentiation and function. Leptin has been associated with disease severity in rheumatoid arthritis (RA). Elevated leptin levels have been detected in the sera and synovial fluid of active RA patients. Th1
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48

Zamzami, Omar M. "Epstein-Barr Virus (EBV) latent membrane protein 1 (LMP1) peptides as inducers of regulatory cells to treat autoimmune haemolytic anaemia." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University member only until May, 2014, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=59565.

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49

Ye, Ping. "Autoimmunity In Chronic Periodontitis." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/4872.

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50

Lai, Mei-chu. "Natural killer cell development and function in autoimmune arthritis." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B3197188X.

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