Academic literature on the topic 'Autoimmune oral lesion'
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Journal articles on the topic "Autoimmune oral lesion"
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Pinheiro, Juliana Barchelli, Camila Tirapelli, Claudia Helena Lovato da Silva, et al. "Oral Nodular Lesions in Patients with Sjögren’s Syndrome: Unusual Oral Implications of a Systemic Disorder." Brazilian Dental Journal 28, no. 3 (2017): 405–12. http://dx.doi.org/10.1590/0103-6440201601013.
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Abstract Sjögren’s syndrome (SS) is a systemic chronic autoimmune disorder affecting the lacrimal and salivary glands. SS may manifest as primary SS (pSS) or secondary SS (sSS), the latter occurring in the context of another autoimmune disorder. In both cases, the dry eyes and mouth affect the patient’s quality of life. Late complications may include blindness, dental tissue destruction, oral candidiasis and lymphoma. This paper reports two cases of SS, each of them presenting unusual oral nodular lesion diagnosed as relapsed MALT lymphoma and mucocele. The importance of the diagnosis, treatment and management of the oral lesions by a dentist during the care of SS patients is emphasized, as the oral manifestations of SS may compromise the patient’s quality of life.
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Tarakji, Bassel. "Pemphigus Vulgaris in Old Patient." Case Reports in Dentistry 2021 (August 23, 2021): 1–3. http://dx.doi.org/10.1155/2021/3946161.
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Pemphigus vulgaris (PV) is a chronic, autoimmune, intraepidermal blistering disease of the skin and mucous membranes. The first clinical manifestation is often the development of intraoral lesions, and later, the lesions involve the other mucous membranes and skin. The etiological factors of this disease still remain unknown, although the presence of autoantibodies is consistent with an autoimmune disease. A 73-year-old man had bullous lesions on gingiva, oral mucosa first, then scalp, trunk, and face. An oral medicine specialist suspects the lesion in differential diagnosis in the first presentation of oral lesions and follows up the patient, and then these bullous lesions presented on the skin. In this article, a patient had received oral prednisolone (80 mg/kg/day) and azathioprine, then tapered oral prednisolone to 40 mg/day, with a reduction of 5 mg/day every three weeks. The patient shows remission of these lesions, and complication of this treatment includes osteoporosis, hyperglycemia, and hypertension.
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Kitakawa, Dárcio, Gabriela Máximo, Maria Clara Ferreira Coelho, Felipe da Silva Peralta, Dárcio Kitakawa, and Luis Felipe das Chagas e Silva de Carvalh. "Erythema multiforme: A case report with oral manifestations." International Journal of Case Reports and Images 13, no. 2 (2023): 61–65. http://dx.doi.org/10.5348/101328z01gm2022cr.
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Introduction: Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, which may be related to herpes simplex virus, use of certain medications, autoimmune disease, radiation, immunization, pregnancy, period, and food additives or chemicals. It is a condition that occurs predominantly in young adults, with a slight female preponderance and no predilection. Clinically, EM presents erosive and erythematous plaques, affecting mainly the lips and oral mucosa, called target lesions, which may progress to vesiculobullous lesions. The aim of this study is to report a case shown as a positive response to treatment. Case Report: This is a case of EM in a 50-year-old female patient with a persistent ulcer on the lower lip. The clinical presentation showed an ulcerated lesion that extended through the right labial vermilion, semi-mucosa and jugal mucosa, in addition to painful symptoms. Although the diagnostic hypothesis of EM, an incisional biopsy was performed, that confirmed the clinical diagnosis of EM. As treatment, topical use of 0.05% clobetasol propionate for 15 days was prescribed on the lesion. The patient returned in seven days with significant improvement of the site. It was decided to do only the follow-up and not to intervene with systemic corticosteroid therapy. The patient is followed up for 15 months without recurrence of the lesion. The histopathological analysis of this type of lesion is essential for the diagnosis of the lesion. In this way, we can rule out differential diagnoses, especially pemphigus vulgaris and in children, hands, feet, and mouths disease. In this work, it was observed how important the histopathological analysis is necessary in more complex cases, because in this way the therapeutic approach was effective. Conclusion: The present case report represents how important the histopathological analysis is necessary in more complex cases to conclude the diagnosis, therefore is possible conduce the best choose of treatment for patient.
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Anitua, Eduardo, Mohammad H. Alkhraisat, Asier Eguia, and Laura Piñas. "Oral Pemphigoid Recalcitrant Lesion Treated with PRGF Infiltration. Case Report." Dentistry Journal 9, no. 11 (2021): 137. http://dx.doi.org/10.3390/dj9110137.
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Mucous membrane pemphigoid (MMP) is a heterogeneous group of chronic autoimmune subepithelial blistering diseases. Oral involvement is present in almost all patients, may represent the onset of the disease, and causes different degrees of pain, dysphagia, soreness, and bleeding. Treatment is based on systemic and/or oral corticoids, or other immunosuppressants. Occasionally, oral lesions can show a poor response to standard treatments. We present the case of a 61-year-old female patient with a painful extensive MMP oral ulcerative lesion recalcitrant to previous systemic azathioprine and local triamcinolone treatment, which was successfully treated in a novel way using PRGF infiltrations as adjuvant. After four weekly infiltrations, pain was reduced from 10 to 0 in a VAS and the lesion was completely healed. The patient continued with a low dose maintenance immunosuppressive treatment (prednisone 5 mg/day PO), and after 13 months of follow-up, there was no relapse of the lesion and no side effects. Although future research is necessary to confirm these observations, PRGF could be a useful adjuvant for the management of extensive mucous membrane pemphigoid oral lesions.
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Cai, Q., and T. Yoo. "Oral Administration Decreases Autoimmune Hearing Loss Lesion in the Mice." Journal of Allergy and Clinical Immunology 117, no. 2 (2006): S18. http://dx.doi.org/10.1016/j.jaci.2005.12.073.
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Sadat, SM Anwar, and Akhter Imam. "Pemphigus Vulgaris as Oral Mucosal Ulcer Progressive to Skin Lesion:." Update Dental College Journal 3, no. 2 (2014): 43–47. http://dx.doi.org/10.3329/updcj.v3i2.17999.
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Among all the life threatening diseases, autoimmune diseases are among most notorious and complicated diseases. As these diseases have no specific cause or responsible organism, it is therefore very difficult to distinguish and diagnose and thus stands as a major threat for public health. It is assumed that the reason for these diseases may be from genetic to environmental factors, from stress to idiopathic origin. Pemphigus Vulgaris(PV) is such an autoimmune blistering disease that frequently affects the mucous membrane and skin. Very often it starts from oral cavity and Dentists therefore the first to recognize. This paper describes the case of a patient presenting with a one-year history of painful ulcerated gingiva, tongue, floor of the mouth and even on GIT who is finally diagnosed as having PV spreading to generalized skin. DOI: http://dx.doi.org/10.3329/updcj.v3i2.17999 Update Dent. Coll. j: 2013; 3 (2): 43-47
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Ohki, Masafumi, and Shigeru Kikuchi. "Nasal, Oral, and Pharyngolaryngeal Manifestations of Pemphigus Vulgaris: Endoscopic Ororhinolaryngologic Examination." Ear, Nose & Throat Journal 96, no. 3 (2017): 120–27. http://dx.doi.org/10.1177/014556131709600311.
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Pemphigus vulgaris is an autoimmune blistering disorder that involves the skin and mucous membranes. Few reports have described nasal and oropharyngolaryngeal lesions in pemphigus vulgaris using an endoscopic ororhinolaryngologic examination. We retrospectively reviewed the clinical records of 11 patients with pemphigus vulgaris between 2001 and 2013 with respect to their symptoms, lesion sites, lesion features, and treatments received. All patients had undergone an endoscopic ororhinolaryngologic examination. Their mucosa-related symptoms were sore throat, oral pain, odynophagia, gingival bleeding, hoarseness, and epistaxis. The most frequent sites were the oral cavity (gingiva and buccal mucosa), larynx (epiglottis and vocal fold), oropharynx (soft palate), and nasal cavity (nasal septum). Lesions were typically characterized by erosion, erosion with a whitish exudate, and erythematous patches. Thus, our study findings reveal that pemphigus vulgaris involves both the nasal and oropharyngolaryngeal regions. Patients with pemphigus vulgaris should undergo an endoscopic ororhinolaryngologic examination to determine the range of their lesions.
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Serpico, R., G. Pannone, A. Santoro, et al. "Report of a Case of Discoid Lupus Erythematosus Localised to the Oral Cavity: Immunofluorescence Findings." International Journal of Immunopathology and Pharmacology 20, no. 3 (2007): 651–53. http://dx.doi.org/10.1177/039463200702000325.
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Discoid Lupus Erythematosus (DLE) is a chronic disease with a typical cutaneous involvement. This pathology rarely involves mucosa: oral cavity is interested in 20% of DLE patients. We describe a case of oral DLE in a 50-year-old woman with an anamnesis for autoimmune disorders. This study shows the helpful role of immunofluorescence in the diagnosis of autoimmune diseases. The first diagnostic step was the clinical observation of the oral mucosa: the lesion area was erythematous, athrophic and hyperkeratotic. The patient then underwent laboratory examination. We utilized human epithelial cells (Hep-2010) for Indirect Immuno-Fluorescence (IIF). Moreover, the biopsy site for Direct Immuno-Fluorescence (DIF) and histopathological analysis was the untreated oral lesion. IIF detected an increase of Anti-Nuclear Antibody (ANA) and positivity for SSA-RO. By DIF, we observed IgG/IgA/fibrinogen along basal layer. Multiple biopsies reported signs of chronic basal damage. Steroid systemic therapy induced a considerable lesion regression. We suggest the use of immunofluorescence with the integration of further data to improve diagnosis of rare diseases and to establish a suitable therapy.
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Jimenez, Antonio, Paige Hoyer, and Michael Wilkerson. "An Atypical Presentation of Pemphigus Vegetans in the Umbilicus." SKIN The Journal of Cutaneous Medicine 4, no. 5 (2020): 452–55. http://dx.doi.org/10.25251/skin.4.5.12.
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Pemphigus is a chronic, autoimmune bullous disease that affects the skin and mucous membranes. Pemphigus vegetans is a rare variant of pemphigus and presents as oral ulcerations with associated verrucous lesions in intertriginous or flexural areas. A 38-year-old African American woman presented to the clinic with a chief complaint of oral ulcers. She carried a diagnosis of Behcet’s disease and was referred by rheumatology for evaluation of treatment-resistant mucosal ulcerations. At the time of her dermatology visit, she also reported an enlarging umbilical mass that had been present for several months. Further examination of the umbilical lesion identified an exophytic, vegetative mass. Histologic assessment of the lesion identified acanthosis and acantholysis with dermal eosinophils consistent with pemphigus vegetans. A pemphigus antibody panel was done and resulted positive for IgG desmoglein-3 antibodies. The patient was treated with prednisone and rituximab with improvement of her lesions. We present an atypical presentation of pemphigus vegetans involving the umbilicus. This diagnosis should be considered in patients who present with oral erosions and concomitant vegetative lesions, regardless of location or prior diagnoses.
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Setiadhi, Riani, and Kosterman Usri. "Oral Lesion Caused by Improper Removable Partial Denture." Jurnal Material Kedokteran Gigi 7, no. 1 (2018): 12. http://dx.doi.org/10.32793/jmkg.v7i1.275.
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Oral lesions are relatively common findings in clinical practice, can occur due to various factors such as trauma, systemic diseases, autoimmune disorders, malignancies. Local trauma as one of the cause of oral lesions majority due to poor dentures, fractured restorations and sharp edges of teeth. The lesions are commonly found on the mucosa that is subjected to the source of trauma such as buccal mucosa, lateral border of the tongue or lips. Removable partial denture is a denture that can be removed and reinserted without professional help. Poor removable denture which is an ill-fitting denture, rough/sharp/overextended flanges, or lack of retention/stability could cause oral lesions. This case report describes a 76 old year man complained of pain on his right lateral tongue since 6 months ago. He was wearing a removable upper right denture which cannot be remove for about a year. It was a rough and sharp self-curing acrylic denture. There was erythematous and pain on his lateral right of the tongue but no induration on palpation. Triamcinolone acetonide 0,1% in orabase was the given treatment for the right lateral of the tongue and referred him to the prosthodontic department for replacing the denture. The oral lesion was healed after one week of treatment and the poor denture was removed. As a conclusion dentures should be made properly by the expert in order to prevent oral lesions.
Dissertations / Theses on the topic "Autoimmune oral lesion"
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FRANCESCHINI, FABIO GIULIO. "Correlazioni esistenti tra parodontologia e medicina orale. Lesioni delle mucose orali versus malattia parodontale. Aspetti diagnostici e terapeutici." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19339.
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Our study describes the relationship between periodontal disease and oral mucosal lesions. At first we analysed classification criteria of oral lesions in order to provide a point of reference for an adequate description. In a second time we started to describe periodontal disease, that is a common pathology all over the world with high costs for therapy and rehabilitations. Also classification of periodontal disease is important, because there are different types of disease, with various clinical aspects. We used the AAP (American Academy of Periodontology) classification of 1999, that reports: gingivitis, chronic periodontitis, aggressive periodontitis, periodontitis related to systemic diseases, necrotizing periodontitis, periodontal abscess, periodontitis associated to endodontic lesions, acquired and developed deformities and conditions. In the second part we described oral mucosal lesions, starting with infective diseases on the basis of etiologic agents: bacterial, viral (with viral neoplasms), fungal, parasitic and syphilitic lesions. In the third part we described autoimmune lesions, in particular the erythema multiform. In the fourth part we analysed the neoplastic and pre-neoplastic diseases, in particular squamous cell carcinoma and leukoplakia. Fifth section is dedicated to “border lesions”, because they are studied both in periodontology and oral medicine. These diseases are the desquamative gingivitis, lichen planus, pemphigoid, pemphigus, linear IgA disease, chronic ulcerative stomatitis and epulid.
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Figueiredo, João Manuel Prata de. "Líquen plano : estudo de casos clínicos." Master's thesis, 2012. http://hdl.handle.net/10400.14/13665.
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O Líquen Plano é uma doença muco cutânea auto-imune que afecta a mucosa oral (Líquen Plano Oral) podendo também afectar pele, mucosa genital, escalpe e unhas. A etiologia exacta do Líquen Plano permanece desconhecida. Esta patologia afecta mais comummente mulheres de meia-idade e raramente afecta crianças. Clinicamente, as lesões de Líquen Plano Oral apresentam-se sob a forma de estrias brancas (estrias Wickham), pápulas brancas, placas brancas, lesões eritematosas, erosivas ou bulhosas. Estas lesões usualmente são simétricas e bilaterais. O diagnóstico do Líquen Plano Oral é efectuado através do exame clínico apenas, ou através do exame clínico e confirmação histopatológica. O tratamento do Líquen Plano Oral é efectuado principalmente com corticoesteróides tópicos, no entanto, outros fármacos têm-se demonstrado eficazes. A transformação maligna do Líquen Plano Oral e a sua incidência exacta permanecem controversas. Este trabalho pretende evidenciar a importância do conhecimento das manifestações orais e sistémicas do Líquen Plano de forma a contribuir para o seu correcto diagnóstico, de modo a proporcionar um melhor prognóstico e tratamento dos pacientes com esta patologia. Para além dos fundamentos teóricos será feita a apresentação de quatro casos clínicos.<br>The lichen planus is an autoimmune skin disease muco-cutaneous that affects the oral mucosa (oral lichen planus), and may also affect skin, genital mucosa, scalp and nails. The exact etiology of lichen planus remains unknown. This condition most commonly affects middle-aged women and rarely affects children. Clinically, lesions of oral lichen planus are presented in the form of white streaks (Wickham striae), white papules, white plates, erythematous, bullous or erosive. These lesions are usually bilateral and symmetrical. Diagnosis of oral lichen planus is made only by clinical examination or by clinical examination and histopathology. The treatment of oral lichen planus is realized mainly with topical corticosteroids, however, other drugs have proven effective. Malignant transformation of oral lichen planus and its exact incidence remains controversial. This paper aims to highlight the importance of knowledge of oral and systemic manifestations of lichen planus to contribute to its correct diagnosis, to provide a better prognosis and treatment of patients with this pathology. In addition to the theoretical foundations four clinical cases shall be presented
Books on the topic "Autoimmune oral lesion"
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Yurdakul, Sebahattin, Emire Seyahi, and Hasan Yazici. Behçet’s syndrome. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0135.
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Behçet's syndrome is a systemic inflammatory panvasculitis (affecting all sizes of vessels) of unknown aetiology. It is in vogue to include it among the systemic autoinflammatory conditions. Behçet's syndrome is more frequent along the ancient 'Silk Route' across Asia than it is in Western countries. The usual onset is the second or third decade, equally affecting either gender. However, young patients and male patients have more severe disease. Almost all patients have recurrent oral ulceration. Scar-forming genital ulcers, a variety of skin lesions including acneiform, erythema nodosum-like lesions, arthritis, potentially blinding panuveitis, thrombophlebitis, gastrointestinal disease, central nervous system (CNS) involvement, and life-threatening bleeding pulmonary artery aneurysms are seen. The pathergy phenomenon is a heightened tissue inflammatory response. The strongest genetic association is with HLA B51. There are immunological aberrations but not prominent enough to call it an autoimmune disease. Similarly, Behçet's syndrome does not fit easily into the broad concept of autoinflammatory diseases. The histopathology is also non-specific and the diagnosis is mainly clinical. Differentiation from Crohn's disease is very difficult. In more than one-half of the patients the disease burns out in time, thus only symptomatic therapy is indicated in some patients. However, eye involvement, pulmonary vascular disease, thrombophilic complications, CNS involvement, and gastrointestinal disease need prompt recognition and treatment. Brief courses of glucocorticosteroids along with immunosuppressives including the newer biologicals, interferon, and colchicine are commonly used. However, controlled clinical trials are not available for some of these medications especially when thrombophilia, CNS, and gastrointestinal disease are present.
Book chapters on the topic "Autoimmune oral lesion"
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SU Kucuk, Ozlem, and Nazan Taslidere. "Pemphigus Vulgaris." In Wound Healing - Recent Advances and Future Opportunities [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104814.
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Pemphigus vulgaris is a life-threatening bullous disease characterized by acantholysis resulting in the formation of intraepithelial blebs in the mucous membranes and skin. It is a chronic autoimmune bullous dermatosis caused by the production of autoantibodies against desmoglein 1 and 3. It often begins with blisters and erosions on the oral mucosa, followed by lesions on other mucous membranes and drooping blisters that may spread to the skin. If there is clinical suspicion, the diagnosis can be confirmed by cytological examination, histopathological examination, direct and indirect immunofluorescence tests. Before the introduction of corticosteroids, PV was fatal due to dehydration or secondary systemic infections. The mainstay of treatment is still systemic steroids. Immunosuppressants such as azathioprine, mycophenolate mofetil and methotrexate, high-dose intravenous immunoglobulins, CD20 monoclonal antibody Rituximab treatments are used as an adjuvant with steroids in suitable patients and successful results are obtained.
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Yurdakul, Sebahattin, Emire Seyahi, and Hasan Yazici. "Behçet’s syndrome." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0135_update_003.
Full textAbstract:
Behçet’s syndrome is a systemic inflammatory panvasculitis (affecting all sizes of vessels) of unknown aetiology. It is in vogue to include it among the systemic autoinflammatory conditions. Behçet’s syndrome is more frequent along the ancient ’Silk Route’ across Asia than it is in Western countries. The usual onset is the second or third decade, equally affecting either gender. However, young patients and male patients have more severe disease. Almost all patients have recurrent oral ulceration. Scar-forming genital ulcers, a variety of skin lesions including acneiform, erythema nodosum-like lesions, arthritis, potentially blinding panuveitis, thrombophlebitis, gastrointestinal disease, central nervous system (CNS) involvement, and life-threatening bleeding pulmonary artery aneurysms are seen. The pathergy phenomenon is a heightened tissue inflammatory response. The strongest genetic association is with HLA B51. There are immunological aberrations but not prominent enough to call it an autoimmune disease. Similarly, Behçet’s syndrome does not fit easily into the broad concept of autoinflammatory diseases. The histopathology is also non-specific and the diagnosis is mainly clinical. Differentiation from Crohn’s disease is very difficult. In more than one-half of the patients the disease burns out in time, thus only symptomatic therapy is indicated in some patients. However, eye involvement, pulmonary vascular disease, thrombophilic complications, CNS involvement, and gastrointestinal disease need prompt recognition and treatment. Brief courses of glucocorticosteroids along with immunosuppressives including the newer biologicals, interferon, and colchicine are commonly used. However, controlled clinical trials are not available for some of these medications especially when thrombophilia, CNS, and gastrointestinal disease are present.
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Yurdakul, Sebahattin, Emire Seyahi, and Hasan Yazici. "Behçet’s syndrome." In Oxford Textbook of Rheumatology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0135_update_004.
Full textAbstract:
Behçet’s syndrome is a systemic inflammatory panvasculitis (affecting all sizes of vessels) of unknown aetiology. It is in vogue to include it among the systemic autoinflammatory conditions. Behçet’s syndrome is more frequent along the ancient ’Silk Route’ across Asia than it is in Western countries. The usual onset is the second or third decade, equally affecting either gender. However, young patients and male patients have more severe disease. Almost all patients have recurrent oral ulceration. Scar-forming genital ulcers, a variety of skin lesions including acneiform, erythema nodosum-like lesions, arthritis, potentially blinding panuveitis, thrombophlebitis, gastrointestinal disease, central nervous system (CNS) involvement, and life-threatening bleeding pulmonary artery aneurysms are seen. The pathergy phenomenon is a heightened tissue inflammatory response. The strongest genetic association is with HLA B51. There are immunological aberrations but not prominent enough to call it an autoimmune disease. Similarly, Behçet’s syndrome does not fit easily into the broad concept of autoinflammatory diseases. The histopathology is also non-specific and the diagnosis is mainly clinical. Differentiation from Crohn’s disease is very difficult. In more than one-half of the patients the disease burns out in time, thus only symptomatic therapy is indicated in some patients. However, eye involvement, pulmonary vascular disease, thrombophilic complications, CNS involvement, and gastrointestinal disease need prompt recognition and treatment. Brief courses of glucocorticosteroids along with immunosuppressives including the newer biologicals, interferon, and colchicine are commonly used. However, controlled clinical trials are not available for some of these medications especially when thrombophilia, CNS, and gastrointestinal disease are present.