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Relevant bibliographies by topics / Autologous chondrocyte implantation Articular cartilage Cartilage repair Review Systemic

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Academic literature on the topic 'Autologous chondrocyte implantation Articular cartilage Cartilage repair Review Systemic'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Autologous chondrocyte implantation Articular cartilage Cartilage repair Review Systemic"

1

Dewan, Ashvin K., Matthew A. Gibson, Jennifer H. Elisseeff, and Michael E. Trice. "Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques." BioMed Research International 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/272481.

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Articular cartilage defects have been addressed using microfracture, abrasion chondroplasty, or osteochondral grafting, but these strategies do not generate tissue that adequately recapitulates native cartilage. During the past 25 years, promising new strategies using assorted scaffolds and cell sources to induce chondrocyte expansion have emerged. We reviewed the evolution of autologous chondrocyte implantation and compared it to other cartilage repair techniques.Methods. We searched PubMed from 1949 to 2014 for the keywords “autologous chondrocyte implantation” (ACI) and “cartilage repair” i

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2

Mistry, Hema, Martin Connock, Joshua Pink, et al. "Autologous chondrocyte implantation in the knee: systematic review and economic evaluation." Health Technology Assessment 21, no. 6 (2017): 1–294. http://dx.doi.org/10.3310/hta21060.

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BackgroundThe surfaces of the bones in the knee are covered with articular cartilage, a rubber-like substance that is very smooth, allowing frictionless movement in the joint and acting as a shock absorber. The cells that form the cartilage are called chondrocytes. Natural cartilage is called hyaline cartilage. Articular cartilage has very little capacity for self-repair, so damage may be permanent. Various methods have been used to try to repair cartilage. Autologous chondrocyte implantation (ACI) involves laboratory culture of cartilage-producing cells from the knee and then implanting them

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3

Ahmadpoor, Xenab, Jessie Sun, Nerone Douglas, Weimin Zhu, and Hang Lin. "Hydrogel-Enhanced Autologous Chondrocyte Implantation for Cartilage Regeneration—An Update on Preclinical Studies." Bioengineering 11, no. 11 (2024): 1164. http://dx.doi.org/10.3390/bioengineering11111164.

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Autologous chondrocyte implantation (ACI) and matrix-induced ACI (MACI) have demonstrated improved clinical outcomes and reduced revision rates for treating osteochondral and chondral defects. However, their ability to achieve lasting, fully functional repair remains limited. To overcome these challenges, scaffold-enhanced ACI, particularly utilizing hydrogel-based biomaterials, has emerged as an innovative strategy. These biomaterials are intended to mimic the biological composition, structural organization, and biomechanical properties of native articular cartilage. This review aims to provi

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Furkan, Ozan. "Improving orthopedic use of stem cell engineering: A mini-review." Ulus Medical Journal 1, no. 1 (2023): 9–11. https://doi.org/10.5281/zenodo.7905315.

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Cell-based therapies for cartilage regeneration have gained popularity as a potential solution to the ongoing problem of articular cartilage repair in orthopedic surgery. There have been some successes with autologous chondrocyte implantation, but there are also some drawbacks. These include limited donor sites, donor site morbidity, dedifferentiation of isolated chondrocytes during monolayer expansion, and poor integration of repair tissue into the native cartilage. The potential of mesenchymal stem cells (MSCs) as a replacement cell source has so gained popularity. Self-renewing, highly expa

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Rehnitz, Christoph, Marc-André Weber, and Felix Wuennemann. "Imaging of the Knee Following Repair of Focal Articular Cartilage Lesions." Seminars in Musculoskeletal Radiology 22, no. 04 (2018): 377–85. http://dx.doi.org/10.1055/s-0038-1667301.

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AbstractFocal chondral or osteochondral lesions of the knee are common lesions involving either the cartilage layers or the cartilage layers and the subchondral bone. Despite their heterogeneous clinical presentation, they are important risk factors for the premature development of osteoarthritis. Therefore, early detection of osteochondral lesions and focal cartilage defects is crucial. In symptomatic (osteo-)chondral lesions, numerous therapeutic strategies, ranging from conservative treatment to surgical procedures such as marrow stimulation, osteochondral autograft transplantation, or auto

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6

Bailey, Andrea, Nicola Goodstone, Sharon Roberts, et al. "Rehabilitation After Oswestry Autologous-Chondrocyte Implantation: The OsCell Protocol." Journal of Sport Rehabilitation 12, no. 2 (2003): 104–18. http://dx.doi.org/10.1123/jsr.12.2.104.

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Objective:To develop a postoperative rehabilitation protocol for patients receiving autologous-chondrocyte implantation (ACI) to repair articular-cartilage defects of the knee.Data Sources:careful review of both basic science and clinical literature, personal communication with colleagues dealing with similar cases, and the authors’ experience and expertise in rehabilitating numerous patients with knee pathologies, injuries, and trauma.Data Synthesis:Postoperative rehabilitation of the ACI patient plays a critical role in the outcome of the procedure. The goals are to improve function and redu

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7

Ogura, Takahiro, Tim Bryant, Gergo Merkely, Brian A. Mosier, and Tom Minas. "Survival Analysis of Revision Autologous Chondrocyte Implantation for Failed ACI." American Journal of Sports Medicine 47, no. 13 (2019): 3212–20. http://dx.doi.org/10.1177/0363546519876630.

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Background: Autologous chondrocyte implantation (ACI) provides a successful outcome for treating articular cartilage lesions. However, there have been very few reports on the clinical outcomes of revision ACI for failed ACI. Purpose: To evaluate clinical outcomes in patients who underwent revision ACI of the knee for failure of an initial ACI and to determine the factors affecting the survival rate. Study Design: Case series; Level of evidence, 4. Methods: A review of a prospectively collected data set was performed from patients who underwent revision ACI of the knee for failure of an initial

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8

Willers, Craig, David J. Wood, and Ming H. Zheng. "A CURRENT REVIEW ON THE BIOLOGY AND TREATMENT OF ARTICULAR CARTILAGE DEFECTS (PART I & PART II)." Journal of Musculoskeletal Research 07, no. 03n04 (2003): 157–81. http://dx.doi.org/10.1142/s0218957703001125.

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Osteochondral injury occurs predominantly in physically active young adult males. Injury to the articular cartilage and/or subchondral bone may not only cause acute joint disease resulting in osseous intracapsular (synovitis) or extracapsular pain, but may also act to spawn arthritic conditions in later life. Since the 18th century, such injury has proven difficult to treat clinically, and much therapy has been essentially palliative. Past treatments such as abrasion arthroplasty, drilling, microfracture and arthroscopic lavage have been useful in removing articular debris and promoting the fo

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9

Dziewic, Jakub, Maria Przygoda, Joanna Śnieżna, et al. "Advancements in Regenerative Medicine for Articular Cartilage Repair in the Management of Osteoarthritis: A Review of Modern Treatment Methods." Quality in Sport 37 (January 19, 2025): 57092. https://doi.org/10.12775/qs.2025.37.57092.

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Osteoarthritis (OA) is the most common form of chronic joint diseases, and its treatment still remains difficult with the current state of medicine. In this review, modern regenerative methods used in the repair of articular cartilage, both traditional techniques and innovative cellular therapies, are described. It focuses on the most updated treatment modalities, discussing, among other methods, microfracture, osteochondral grafts, autologous chondrocyte implantation (ACI), novel approaches of matrix-assisted autologous chondrocyte transplantation (MACT) and mesenchymal stem cell (MSC) treatm

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10

Pasic, Nicholas, Hannah L. Bradsell, Andres Barandiaran, et al. "Rate of Conversion to Matrix-Induced Autologous Chondrocyte Implantation After a Biopsy: A Multisurgeon Study." Orthopaedic Journal of Sports Medicine 11, no. 5 (2023): 232596712311607. http://dx.doi.org/10.1177/23259671231160732.

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Background: Autologous chondrocyte implantation (ACI) and matrix-induced autologous chondrocyte implantation (MACI) are performed to treat focal chondral defects (FCDs); both are 2-step procedures involving a biopsy, followed by transplantation. There is little published research evaluating ACI/MACI in patients who undergo a biopsy alone. Purpose: To determine (1) the value of ACI/MACI cartilage biopsies and concomitant procedures in patients with FCDs of the knee and (2) the conversion rate to cartilage transplantation as well as the rate of reoperation. Study Design: Case series; Level of ev

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