Relevant bibliographies by topics / Automatic Solid Phase Peptide Synthesis

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Academic literature on the topic 'Automatic Solid Phase Peptide Synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 5 February 2022

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Journal articles on the topic "Automatic Solid Phase Peptide Synthesis"

1

Mäde, Veronika, Sylvia Els-Heindl, and Annette G. Beck-Sickinger. "Automated solid-phase peptide synthesis to obtain therapeutic peptides." Beilstein Journal of Organic Chemistry 10 (May 22, 2014): 1197–212. http://dx.doi.org/10.3762/bjoc.10.118.

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The great versatility and the inherent high affinities of peptides for their respective targets have led to tremendous progress for therapeutic applications in the last years. In order to increase the drugability of these frequently unstable and rapidly cleared molecules, chemical modifications are of great interest. Automated solid-phase peptide synthesis (SPPS) offers a suitable technology to produce chemically engineered peptides. This review concentrates on the application of SPPS by Fmoc/t-Bu protecting-group strategy, which is most commonly used. Critical issues and suggestions for the s
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Maede, Veronika, Sylvia Els-Heindl, and Annette G. Beck-Sickinger. "ChemInform Abstract: Automated Solid-Phase Peptide Synthesis to Obtain Therapeutic Peptides." ChemInform 46, no. 6 (2015): no. http://dx.doi.org/10.1002/chin.201506294.

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NOKIHARA, Kiyoshi. "Highly Efficient Peptide Synthesis: Automated Simultaneous Multiple Solid-Phase Synthesis and Peptide Library." Journal of Synthetic Organic Chemistry, Japan 52, no. 5 (1994): 347–58. http://dx.doi.org/10.5059/yukigoseikyokaishi.52.347.

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Zieleniewski, Francis, Derek N. Woolfson, and Jonathan Clayden. "Automated solid-phase concatenation of Aib residues to form long, water-soluble, helical peptides." Chemical Communications 56, no. 80 (2020): 12049–52. http://dx.doi.org/10.1039/d0cc04698a.

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Cammish, Linda E., and Steven A. Kates. "ChemInform Abstract: Instrumentation for Automated Solid Phase Peptide Synthesis." ChemInform 31, no. 45 (2000): no. http://dx.doi.org/10.1002/chin.200045267.

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Stephenson, Karin A., Sangeeta Ray Banerjee, Nicole McFarlane, et al. "A convenient solid-phase synthesis methodology for preparing peptide-derived molecular imaging agents — Synthesis, characterization, and in vitro screening of Tc(I) – chemotactic peptide conjugates." Canadian Journal of Chemistry 83, no. 12 (2005): 2060–66. http://dx.doi.org/10.1139/v05-224.

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A versatile solid-phase synthesis strategy for preparing peptide–chelate conjugates was developed. The methodology was optimized using a series of ligands, designed to bind Tc(I)/Re(I), and a chemotactic peptide fMFL, which was exploited as a model targeting vector. The peptide derivatives were prepared in parallel using a conventional automated peptide synthesizer in multi-milligram quantities, which provided sufficient material to perform complete characterization, radiolabelling, and in vitro screening studies. Because of the robust nature of the metal–chelate complexes, the Re complex of a
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Hurevich, Mattan, and Peter H. Seeberger. "Automated glycopeptide assembly by combined solid-phase peptide and oligosaccharide synthesis." Chem. Commun. 50, no. 15 (2014): 1851–53. http://dx.doi.org/10.1039/c3cc48761j.

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Automated synthesis of glycopeptides was achieved using monosaccharide and amino acid building blocks. Using polystyrene beads equipped with photo-labile linker as solid support, all synthetic manipulations were performed using a single instrument.
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Buckman, Brad, Ameen Ghannam, Angela Li, Meina Liang, Raju Mohan, and Howard Ng. "Automated Parallel Solid-Phase Synthesis of Non-Peptide CCR1 Receptor Antagonists." Combinatorial Chemistry & High Throughput Screening 5, no. 3 (2002): 249–51. http://dx.doi.org/10.2174/1386207024607284.

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Zhang, Jing, and Ya Dong Zhang. "Solid Phase Synthesis of Novel Fullerene Nucleotides Conjugates." Advanced Materials Research 266 (June 2011): 200–203. http://dx.doi.org/10.4028/www.scientific.net/amr.266.200.

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N-substituted 3, 4-fullero pyrrolidine was synthesized according to 1, 3-dipolar cycloaddition of the azomethine ylide. Aspartic acid with protected α-amino and α-carboxyl groups was reacted with the activated hydroxyl group of N-substituted 3, 4-fullero pyrrolidine. The products were deprotected, affording the monofullerene aspartic acid (mFas). The conjugate FasT was synthesized by reaction of mFas containing protected amino group with the thymidylic acid derivatived controlled pore glass (CPG) using solid phase synthesis. All of the above fullerene derivatives were characterized by UV–vis,
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Ozerskay, A. V., K. V. Belugin, and O. N. Badmaev. "The use of prosthetic groups for synthesis of addressed RFLP molecules for positron emission tomography." Siberian Medical Review, no. 2 (2021): 84–86. http://dx.doi.org/10.20333/25000136-2021-2-84-86.

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The aim of the research. An intensive research is underway to create new methods for the synthesis of fl uorine-18 labeled radiopharmaceuticals. Th e aim of this work is to select iodoaliphatic carboxylic acids and esters for radiopharmaceuticals labeling. Material and methods. A simple way to obtain z-yodalifi c carbonic acids and complex esters from commercially available cyclic ketones has been developed. Automatic synthesis of 18F-fl uoroproprostatic groups and 18F fl uoride peptide agents is successfully carried out using new original materials and various purifi cation methods with solid
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Dissertations / Theses on the topic "Automatic Solid Phase Peptide Synthesis"

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Pahlke, Denis. "Synthesis, characterisation and sensor-functionalisation of transmembrane β-peptides". Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/21.11130/00-1735-0000-0003-C180-1.

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Adamson, R. "Solid phase peptide synthesis." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371460.

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Raphy, Gilles. "Solid phase peptide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/14254.

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A new method of purification has been developed for peptides synthesised by the Merrifield solid phase methodology. N<SUP>PROB*LEM</SUP>-17-Tetrabenzo(a,c,g,i)fluorenylmethoxycarbonyl glycine (Tbfmoc Gly OH) has been prepared, and coupled <i>via</i> its symmetrical anhydride or its HOBt ester to the N-terminus of a peptide at the final stage of the synthesis. The strong affinity of the Tbfmoc group for graphitised carbon (PGC) allows the retention of Tbfmoc-protected peptides on a column packed with this material, whilst incorrectly terminated sequences and other materials are washed away. Fol
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McInnes, Campbell. "New methodology for solid phase peptide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/12616.

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A novel linker for the solid phase synthesis of peptide amides is described. This linker based on 2-alkoxydibenzocycloheptadiene enables release of the peptide derivative under very mild conditions and is compatible with base labile N-alpha protecting groups. The efficacy of this linker in generating c-terminal peptide amides has been demonstrated in the synthesis of the natural products, little gastrin, big gastrin, substance P and bombesin. Modification of the linker allows peptide hydrazides to be prepared. The use of the linker in producing unprotected peptide hydrazides has been exemplifi
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Richards, Mark Ian. "Refined methods in solid (gel) phase peptide synthesis." Thesis, University of Wolverhampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343258.

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Dirscherl, Georg. "Solid-phase synthesis of peptide - metal-complex conjugates." kostenfrei, 2007. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/902/.

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Hewage, Gihan B. (Gihan Bhagye). "Advancements in polymer resins for solid-phase peptide synthesis." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105055.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 28-30).<br>The use of polymeric supports in solid-phase peptide synthesis has allowed for the facile, rapid synthesis of short peptides in a one bead/one sequence manner. This approach allows for screening peptide libraries for binding and catalytic activities. Once hits are found, the sequence of the active protein can be determined via mass spectrometry. However, problems arise when trying to create large libraries (on the
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Holland, David Richard. "Allylation of glycine equivalents during solid phase peptide synthesis." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311452.

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McIntyre, Denise Lynne. "Novel linkers for the solid-phase synthesis of peptide aldehydes." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11846.

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Serine and cysteine proteases are potently inhibited by peptide aldehydes. Compared with the plethora of methods available for solution synthesis of peptide aldehydes, there are relatively few methods for the solid phase synthesis of peptide aldehydes. The development of novel linkers for the solid phase synthesis of peptide aldehydes is reported (Scheme 1). When X = N, the aldehyde 4 can be cleaved in mild acid with 97% enantiomeric excess (e.e.). When X = O, base hydrolysis results in aldehyde 4 cleavage with complete epimerisation of the α-stereocentre. The use of <i>Mucor meihei</i> lipase
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Corrihons, Fabien. "Solid phase peptide synthesis of cyclic peptides for cancer oncology." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424312.

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Books on the topic "Automatic Solid Phase Peptide Synthesis"

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C, Sheppard R., ed. Solid phase peptide synthesis: A practical approach. IRL Press at Oxford University Press, 1989.

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Richards, Mark Ian. Refined methods in solid (gel) phase peptide synthesis. University of Wolverhampton, 2001.

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Coffey, Andrew Franklin. A new approach to computer controlled solid (gel) phase peptide synthesis. University of Wolverhampton, 1990.

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Life during a golden age of peptide chemistry: The concept and development of solid-phase peptide synthesis. American Chemical Society, 1993.

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Butwell, Francis G. W. A 13C n.m.r. study of ultra-high-load solid (gel) phase peptide synthesis. The Polytechnic, Wolverhampton, School of Applied Sciences, 1988.

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Mole, Edward John. Side chain protecting strategies in ultra-high load solid (gel) phase peptide synthesis. ThePolytechnic, Wolverhampton, School of Applied Sciences, 1988.

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Chan, W., and Peter White, eds. Fmoc Solid Phase Peptide Synthesis. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637256.001.0001.

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In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems outstanding at the time of publication of this earlier work have now been, for the most part, solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers not only the essential procedures for the production
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C, Chan Weng, and White Peter D, eds. Fmoc solid phase peptide synthesis: A practical approach. Oxford University Press, 2000.

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(Editor), W. C. Chan, and Peter D. White (Editor), eds. Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series). Oxford University Press, USA, 2000.

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Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series). Oxford University Press, USA, 2000.

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Book chapters on the topic "Automatic Solid Phase Peptide Synthesis"

1

Winkler, Dirk F. H. "Automated Solid-Phase Peptide Synthesis." In Methods in Molecular Biology. Springer US, 2019. http://dx.doi.org/10.1007/978-1-0716-0227-0_5.

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Gausepohl, Heinrich, and Christian Behn. "Automated Synthesis of Solid-Phase Bound Peptides." In Peptide Arrays on Membrane Supports. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-09229-3_4.

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de Bont, H. B. A., J. H. van Boom, and R. M. J. Liskamp. "Automatic synthesis of phosphopeptides on the solid phase." In Peptides 1990. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_187.

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Neimark, J., and J. P. Briand. "An automated device for solid-phase multiple peptide synthesis." In Peptides 1990. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_84.

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Fields, C. G., D. H. Lloyd, R. L. Macdonald, K. M. Otteson, and R. L. Noble. "Application of HBTU activation for automated Fmoc solid phase peptide synthesis." In Peptides 1990. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_23.

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Kates, S. A., S. B. Daniels, N. A. Solé, G. Barany, and F. Albericio. "Automated allyl chemistry for solid-phase peptide synthesis: Applications to cyclic and branched peptides." In Peptides. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-0683-2_32.

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Voelter, W., H. Kalbacher, H. Echner, B. Schmid, C. Schröder, and U. Treffer. "Isolation of a new thymosin from trout spleen and the automatic solid phase synthesis of its proposed sequence." In Peptides 1990. Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3034-9_87.

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Lee, Yeon Sun, Hyun Jin Lee, Doyoung Lee, and Hack-Joo Kim. "Nsc- and Fmoc-amino acids for automated solid-phase peptide synthesis: Comparative study of the stability in various conditions." In Peptides for the New Millennium. Springer Netherlands, 2002. http://dx.doi.org/10.1007/0-306-46881-6_17.

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Bodanszky, Miklos. "Solid Phase Peptide Synthesis." In Peptide Chemistry. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-97886-9_10.

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Bodanszky, Miklos. "Solid Phase Peptide Synthesis." In Peptide Chemistry. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-78206-0_10.

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Conference papers on the topic "Automatic Solid Phase Peptide Synthesis"

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Niethammer, Felix, Daniel Maisch, and Marcus Rothe. "Evaluation of the ”ResPep continuousflow synthesizer” with real-time UVmonitoring, automated feedback & heating in solid phase peptide synthesis." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.116.

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Barany, George. "Orthogonal Solid-Phase Peptide Synthesis." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.001.

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Turcotte, Stéphane, and William D. Lubell. "Solid-Phase Synthesis of Azasulfurylphenylalanine4-GHRP-6." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.040.

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de la Torre, Beatriz G., Ashish Kumar, Yahya Jad, et al. "Solid-phase peptide synthesis: the Greener, the Better." In 35th European Peptide Symposium. Prompt Scientific Publishing, 2018. http://dx.doi.org/10.17952/35eps.2018.099.

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Pomo-Villar, Esteban, Encarnacion Nogueira, Maria del Carmen Fernandez, et al. "Synthesis of Protected Thiophospho Amino Acids for Solid Phase Peptide Synthesis." In The 1st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02027.

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Merrifield, Bruce. "Solid phase peptide synthesis: New chemistry and new directions." In Future Aspect in Peptide Chemistry - Ringberg Conference. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199901012.

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Traore, Mariam, and William D. Lubell. "Solid-Phase Synthesis of Aza-Lysine Peptide Analogue of Trypsin Substrate." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.202.

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Ciencialová, Alice, Lenka Klasová, Jiří Jiráček, Jana Barthová, and Tomislav Barth. "Fluorescent labeled amino acid utilizable in solid phase peptide synthesis." In VIIth Conference Biologically Active Peptides. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2001. http://dx.doi.org/10.1135/css200104041.

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Fuente-Moreno, M., A. Oddo, M. Sheykhzade, D. S. Pickering, and P. R. Hansen. "Fmoc Solid-Phase Peptide Synthesis of Human alfa-Calcitonin Gene-Related Peptide and Two Fluorescent Analogs." In The 24th American Peptide Symposium. Prompt Scientific Publishing, 2015. http://dx.doi.org/10.17952/24aps.2015.264.

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Mahmoodi, Mohammad M., Tomohiro Kubo, Daniel Abate-Pella, Jane E. Wissinger, and Mark D. Distefano. "Solvent-Free Synthesis of Bhc-Cl and Application to Cysteine Protection in Solid Phase Peptide Synthesis." In The Twenty-Third American and the Sixth International Peptide Symposium. Prompt Scientific Publishing, 2013. http://dx.doi.org/10.17952/23aps.2013.248.

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Reports on the topic "Automatic Solid Phase Peptide Synthesis"

1

Vouros, Paul, and Terrance Black. Solid Phase Peptide Synthesis of Antimicrobial Peptides for cell Binding Studies: Characterization Using Mass Spectrometry. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada412571.

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