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Dissertations / Theses on the topic 'Automatic Solid Phase Peptide Synthesis'

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Published: 4 June 2021

Last updated: 5 February 2022

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1

Pahlke, Denis. "Synthesis, characterisation and sensor-functionalisation of transmembrane β-peptides". Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://hdl.handle.net/21.11130/00-1735-0000-0003-C180-1.

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2

Adamson, R. "Solid phase peptide synthesis." Thesis, University of Bradford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371460.

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3

Raphy, Gilles. "Solid phase peptide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/14254.

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A new method of purification has been developed for peptides synthesised by the Merrifield solid phase methodology. N<SUP>PROB*LEM</SUP>-17-Tetrabenzo(a,c,g,i)fluorenylmethoxycarbonyl glycine (Tbfmoc Gly OH) has been prepared, and coupled <i>via</i> its symmetrical anhydride or its HOBt ester to the N-terminus of a peptide at the final stage of the synthesis. The strong affinity of the Tbfmoc group for graphitised carbon (PGC) allows the retention of Tbfmoc-protected peptides on a column packed with this material, whilst incorrectly terminated sequences and other materials are washed away. Fol

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4

McInnes, Campbell. "New methodology for solid phase peptide synthesis." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/12616.

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A novel linker for the solid phase synthesis of peptide amides is described. This linker based on 2-alkoxydibenzocycloheptadiene enables release of the peptide derivative under very mild conditions and is compatible with base labile N-alpha protecting groups. The efficacy of this linker in generating c-terminal peptide amides has been demonstrated in the synthesis of the natural products, little gastrin, big gastrin, substance P and bombesin. Modification of the linker allows peptide hydrazides to be prepared. The use of the linker in producing unprotected peptide hydrazides has been exemplifi

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5

Richards, Mark Ian. "Refined methods in solid (gel) phase peptide synthesis." Thesis, University of Wolverhampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343258.

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6

Dirscherl, Georg. "Solid-phase synthesis of peptide - metal-complex conjugates." kostenfrei, 2007. http://www.opus-bayern.de/uni-regensburg/volltexte/2009/902/.

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7

Hewage, Gihan B. (Gihan Bhagye). "Advancements in polymer resins for solid-phase peptide synthesis." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/105055.

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Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 28-30).<br>The use of polymeric supports in solid-phase peptide synthesis has allowed for the facile, rapid synthesis of short peptides in a one bead/one sequence manner. This approach allows for screening peptide libraries for binding and catalytic activities. Once hits are found, the sequence of the active protein can be determined via mass spectrometry. However, problems arise when trying to create large libraries (on the

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8

Holland, David Richard. "Allylation of glycine equivalents during solid phase peptide synthesis." Thesis, University of Bath, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311452.

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9

McIntyre, Denise Lynne. "Novel linkers for the solid-phase synthesis of peptide aldehydes." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11846.

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Serine and cysteine proteases are potently inhibited by peptide aldehydes. Compared with the plethora of methods available for solution synthesis of peptide aldehydes, there are relatively few methods for the solid phase synthesis of peptide aldehydes. The development of novel linkers for the solid phase synthesis of peptide aldehydes is reported (Scheme 1). When X = N, the aldehyde 4 can be cleaved in mild acid with 97% enantiomeric excess (e.e.). When X = O, base hydrolysis results in aldehyde 4 cleavage with complete epimerisation of the α-stereocentre. The use of <i>Mucor meihei</i> lipase

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10

Corrihons, Fabien. "Solid phase peptide synthesis of cyclic peptides for cancer oncology." Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424312.

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11

Longstaff, Peter A. "Novel side chain protecting groups for solid phase peptide synthesis." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/15232.

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12

Staveren, Dave Richard van. "Robust transition metal markers for labelling of peptides via solid phase synthesis methods." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962393665.

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13

Selim, Erik. "Solid-phase synthesis of Avian β-Defensin 8". Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-32076.

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Differences in the expression of antimicrobial peptides in vivo have been proposed as underlying factors influencing susceptibility to infection. In this context, the role of avian b-defensins in inhibiting avian influenza infections is a study object in an ongoing collaboration with the Zoonotic Ecology and Epidemiology group at Lnu. In this report, an attempt to synthesize two variants of the peptide Anas Platyrhynchos AvBD-8, using Fmoc-based SPPS, is described. The length of AvBD-8 (43 aa) necessitated peptide synthesis in two segments to subsequently be ligated using native chemical ligat

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14

Poma, Alessandro. "Automatic solid-phase synthesis of molecularly imprinted nanoparticles (MIP NPs)." Thesis, Cranfield University, 2012. http://dspace.lib.cranfield.ac.uk/handle/1826/7911.

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Molecularly Imprinted Polymers (MIPs) are potential generic alternatives to antibodies in diagnostics and separations. To compete with biomolecules in these technological niches, MIPs need to share the characteristics of antibodies (solubility, size, specificity and affinity) whilst maintaining the advantages of MIPs (low cost, short development time and high stability). For this reason the interest in preparing MIPs as nanoparticles (MIP NPs) has increased exponentially in the last decade. Cont/d.

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15

Egner, Bryan James. "Solid phase synthesis of lysobactin analogues and reaction monitoring by SPIMS." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242298.

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16

Urquhart, Kirstie. "Investigation of the interleukin-1β converting enzyme : solid phase peptide synthesis studies". Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/11488.

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An investigation of the substrate requirements of the interleukin-1β (IL-1β) converting enzyme (ICE) has been carried out. Solid phase peptide synthesis has been used to synthesise sequences from precursor IL-1β, a cowpox inhibitor crmA, and the pro region of ICE. The peptides have been assayed to ascertain their inhibitory properties. In the course of this work an attempt has been made to establish a simple way of introducing β-turns into peptides. This has been carried out by the formation of a disulphide bridged species in which cystine formation was facilitated by the use of the turn-induc

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17

Knauer, Sascha [Verfasser], Harald [Akademischer Betreuer] Kolmar, Katja [Akademischer Betreuer] Schmitz, and Oliver [Akademischer Betreuer] Seitz. "Aqueous solid-phase peptide synthesis (ASPPS): A novel concept of peptide synthesis / Sascha Knauer ; Harald Kolmar, Katja Schmitz, Oliver Seitz." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://d-nb.info/1206688696/34.

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18

Knauer, Sascha [Verfasser], Harald Akademischer Betreuer] Kolmar, Katja [Akademischer Betreuer] Schmitz, and Oliver [Akademischer Betreuer] [Seitz. "Aqueous solid-phase peptide synthesis (ASPPS): A novel concept of peptide synthesis / Sascha Knauer ; Harald Kolmar, Katja Schmitz, Oliver Seitz." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2020. http://d-nb.info/1206688696/34.

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19

Parekh, Harendra S. "Development of a novel carboxy linker for solid phase peptide and glycopeptide synthesis." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395581.

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20

Butwell, F. G. W. "A '1'3C n.m.r. study of ultra-high-load solid (gel) phase peptide synthesis." Thesis, University of Wolverhampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383515.

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21

Umeobika, Ugochukwu Christian. "Solid phase peptide synthesis of substrates for the chemoenzymatic generation of cyanobactins analogues." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=233678.

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Ribosomal synthesized and post translational modified peptide natural products have attracted a lot of interest in the past decade. Backbone cyclization of the translated linear peptides is generally catalysed by specific enzymes giving them peptidase resistance, thermodynamic stability and various other physiological activities. These features have made backbone cyclic peptide to become an attractive resource for drug discovery. Here, we described the synthesis of linear peptides containing natural and unnatural residues and its biosynthetic mechanism to generate man-made cyclic peptides. In

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22

Carswell, Robert John. "Synthesis of liquid crystalline oligopeptides and discotic molecules designed for additional structure formation." Thesis, University of Strathclyde, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366800.

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23

Rosés, Subirós Cristina. "Solid-phase synthesis of cell-penetrating γ-peptide/antimicrobial peptide conjugates and of cyclic lipodepsipeptides derived from fengycins". Doctoral thesis, Universitat de Girona, 2016. http://hdl.handle.net/10803/393895.

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This thesis is focused on the development of synthetic approaches to obtain new bioactive peptides. The first part deals with the design of new antimicrobial peptide/cell-penetrating peptide conjugates as anticancer agents. Their conjugation enhanced the activity of the antimicrobial peptides against cancer cells while maintained their low toxicity. These compounds are interesting for the design of new anticancer agents. On the second part, a new versatile methodology for the synthesis of natural fengycin derivatives is described. Our strategy represents the first synthetic approach for the to

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24

Hone, Neal. "The synthesis of atypical amino acids and peptides utilizing solid phase peptide synthesis and novel amine protection." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357925.

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25

Baker, Philip Andrew. "Synthesis, evaluation and application of functionally modified supports for ultra-high load solid (gel) phase peptide synthesis." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237678.

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26

Mellor, Sarah Louise. "Development of novel solid-phase chemistry and building blocks for the synthesis of antimicrobial peptides." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243473.

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27

Sasubilli, Ramakrishna Gutheil William G. "Solid-phase synthesis of peptides and peptide mimetics using urethane and backbone amide linker strategies." Diss., UMK access, 2006.

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Thesis (M.S.)--School of Pharmacy. University of Missouri--Kansas City, 2006.<br>"A thesis in pharmaceutical sciences." Typescript. Advisor: William G. Gutheil. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 9, 2007. Includes bibliographical references (leaves 63-73). Online version of the print edition.

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28

Ruda, Marcus. "Design and synthesis of steroid mimetic libraries using solid phase techniques /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-049-4/.

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29

Johnson, Tony. "Ultra-high load solid (gel) phase peptide synthesis using a combination of acid labile and base labile N-terminal protecting groups." Thesis, University of Wolverhampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328036.

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30

Gupta, Chitrak. "Peptide Bond Geometry Studied by Solid-State NMR Spectroscopy." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385331897.

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31

Voglmeir, Josef. "Expression of Peptide- and Glycopeptide Modifying Glycosyltransferases for Applications in Liquid- and Solid Phase Carbohydrate Synthesis." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508597.

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32

Nash, Ian Alun. "The development of solid phase strategies and methodologies : the synthesis of polyamine toxins and peptide nucleic acids." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321373.

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33

Kellam, Barrie. "The development of novel solid phase methodologies for the synthesis of atypical peptides and non-peptide entities." Thesis, University of Nottingham, 1996. http://eprints.nottingham.ac.uk/10381/.

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Solid phase peptide synthesis (SPPS) of branched/cyclic peptides, multiple antigenic peptides (MAPs), pseudopeptide toxins etc. requires amine protection orthogonal to the established Fmoc/Boc protocols. It was envisaged that progression from Dde to N-1-(4-Nitro-l,3-dioxoindan-2-ylidene)ethyl (Nde) amino acid protection would maintain the stipulated orthogonality, whilst improving the hydrazine mediated deprotection. A selection of Nα-Nde-amino acids were efficiently synthesised and their compatibility with SPPS conditions demonstrated by the synthesis of a number of peptides. The Nde group di

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34

Xu, Jingjing. "Solid-phase synthesis of molecularly imprinted polymer nanoparticles for protein recognition." Thesis, Compiègne, 2017. http://www.theses.fr/2017COMP2349/document.

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Cette thèse décrit la synthèse de nanoparticules de polymères à empreintes moléculaires (MIP, de l’anglais molecularly imprinted polymer) pour la reconnaissance de protéines, par une approche de synthèse en phase solide. Les polymères à empreintes moléculaires sont des récepteurs biomimétiques synthétisés sur mesure par un processus de nanomoulage du polymère autour de la molécule unique. Ils possèdent ainsi des cavités de reconnaissance spécifiques pour leur molécule cible. La technique de l'impression moléculaire pour les petites molécules cibles est bien établie, alors que l'impression de p

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35

Alzakhem, Nicola [Verfasser], Michael [Gutachter] Seitz, and Martin [Gutachter] Feigel. "Stable lanthanide cryptates as building blocks for solid phase peptide synthesis / Nicola Alzakhem ; Gutachter: Michael Seitz, Martin Feigel." Bochum : Ruhr-Universität Bochum, 2013. http://d-nb.info/1136131213/34.

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36

Jones, David Anthony. "The use of amino acid silyl esters in solid-phase peptide synthesis in the N-to-C direction." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296268.

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37

Jackson, Marcus J. "DESIGN OF A SCREENING PROCESS FOR THE DEVELOPMENT." Master's thesis, Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/202826.

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Chemistry<br>M.A.<br>We have initiated the development of a screening platform to design a library of small molecules on the same solid support surface. This solid support surface, and the chemistry involved, can be utilized as a means of developing lead target molecules, namely ligands and catalysts. Evidence shows the successful assembly of both simple amino acids, as well as successful employment of our synthetic compounds. We support our efforts by showing compatibility for binding studies with larger macromolecules. Thus, intrigue remains by the prospects of this project. Challenges withi

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38

Osborn, Nigel John. "Characterisation of two antipeptide antibodies and the synthesis and implementation of a novel linker for use in Fmoc solid-phase peptide synthesis." Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386763.

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39

Jarikote, Dilip Venkatrao. "Solid phase synthesis of thiazole orange labeled peptide nucleic acids for homogeneous detection of single base mutation in DNA." Doctoral thesis, [S.l.] : [s.n.], 2007. http://deposit.ddb.de/cgi-bin/dokserv?idn=983553203.

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40

Drew, Daniel L. Jr. "Investigating the Structure and Dynamic Properties of Bacteriophage S21 Pinholin Using Solid-State Nuclear Magnetic Resonance and Electron Paramagnetic Resonance Spectroscopy." Miami University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=miami1610187893016095.

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41

Lindgren, Joel. "Chemical Engineering of Small Affinity Proteins." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-141014.

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Small robust affinity proteins have shown great potential for use in therapy, in vivo diagnostics, and various biotechnological applications. However, the affinity proteins often need to be modified or functionalized to be successful in many of these applications. The use of chemical synthesis for the production of the proteins can allow for site-directed functionalization not achievable by recombinant routes, including incorporation of unnatural building blocks. This thesis focuses on chemical engineering of Affibody molecules and an albumin binding domain (ABD), which both are three-helix bu

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42

Pudelko, Maciej. "Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides." Doctoral thesis, Umeå : Department of Chemistry, Umeå Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1630.

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43

Nordström, Peter. "Minimizing Liquid Waste in Peptide Synthesis : A New Application for the Rotating Bed Reactor." Thesis, Umeå universitet, Institutionen för fysik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-184016.

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Peptide drugs are used to treat a broad spectrum of diseases such as cancer and HIV and have many more promising applications, such as new vaccines against SARS-CoV-2. The most popular manufacturing method for peptides is solid-phase peptide synthesis (SPPS). The main drawback of SPPS is that it is a costly and wasteful process. SpinChem is a company that provides technology solutions for chemical processes. Recently, SpinChem has started investigating if their Rotating Bed Reactor (RBR) is suitable for peptide synthesis. The goal of this project is to investigate how the RBR can make process

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44

Yu, Ruixuan Ryan. "Hybrid-Phase Native Chemical Ligation Approaches to Overcome the Limitations of Protein Total Synthesis." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1469191712.

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45

Kheirabadi, Mahboubeh. "Inside-out design and synthesis of spiroligomers for transesterification reactions." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/304046.

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Chemistry<br>Ph.D.<br>This work describes the application of spiroligomers as serine hydrolases mimetics. Through collaboration with Kendall Houk's group, for the first time in the Schafmeister lab, we demonstrate that "theozymes" can be successfully used as models to design highly functionalized spiroligomer constructs for organocatalysis. We demonstrate a structure-function relationship between the structure of a series of bi-functional and tri-functional spiroligomer based transesterification catalysts and their catalytic activity. First, we designed and synthesized a series of stereochemic

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46

Sani, Marc-Antoine. "Apoptosis Regulation via the Mitochondrial Pathway : Membrane Response upon Apoptotic Stimuli." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1883.

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The aim of this thesis was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of lipids in the context of apoptotic regulation occurring at the mitochondrion and its complex membrane systems. The BH4 domain is an anti-apoptotic specific domain of the Bcl-2 protein. Solid phase peptide synthesis was used to produce large amount of the peptide for biophysical studies. A protocol has been established and optimized, guarantying the required purity for biophysica

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47

Shah, Kinjalkumar K. "Design, Synthesis and Characterization of Heme-proteins: Developing Potential Catalysts for Bio-remediation." Thesis, Virginia Tech, 2004. http://hdl.handle.net/10919/31187.

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The next generation of toxic chemicals and hazardous wastes from sophisticated chemical industries will demand the environmental agencies to employ biological methods over the conventional physical and chemical remediation methods. Over the past decade, natural metallo-enzymes have been identified to degrade some of the major chemical contaminants through electron transfer pathways. However, these natural enzymes are less stable in organic solvents and they are not effective for the degradation of toxic compounds such as polychlorinated biphenyls or dioxins. This thesis explores the use of pro

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48

Joo, Sang Hoon. "Synthesis and screening of support-bound combinatorial cyclic peptide and free C-terminal peptide libraries." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195561420.

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49

Nygren, Patrik. "Bioorganisk fastfas syntes för att skapa intelligenta ytor." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-2272.

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<p>This thesis investigates three different surface modifications, and the route to design and synthesize them. The thesis is therefore divided into three sub- projects. (i.) Design and synthesis of a peptide which secondary structure could be controlled by a negatively charged surface. (ii.) Design and synthesis of a cyclic peptide, that would self-organize prior to surface interaction, using the type I anti-freeze protein of a winter flounder as template. (iii.) The use of solid-phase synthesis to make the synthesis of SAM-molecules easier.</p>

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50

Josan, Jatinder Singh. "Heteromultivalent Ligands Directed Targeting of Cell-Surface Receptors - Implications in Cancer Diagnostics and Therapeutics." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193592.

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Effective detection and treatment of tumor malignancies depends upon identifying targets – molecular markers that differentiate cancer cells from healthy cells. Current cancer therapies involve targeting overexpressed specific gene products. An alternative approach is proposed here: to specifically target combinations of cell-surface receptors using heteromultivalent ligands (htMVLs). There are about 2500 genes encoding for cellsurface proteins in the human genome that can potentially be targeted. Taken as sets, there can be ~ 10⁶ two-receptor combinations and ~ 10⁹ three-receptor combinations

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