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Journal articles on the topic 'Autopsy brain'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Swerdlow, Russell H., Mony J. de Leon, and David L. Marcus. "Betahydroxybutyrate Consumption in Autopsy Brain Tissue from Alzheimer’s Disease Subjects." Journal of Alzheimer's Disease Reports 5, no. 1 (2021): 135–41. http://dx.doi.org/10.3233/adr-210002.

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Background: Alzheimer’s disease (AD) features perturbed brain glucose utilization, which could contribute to brain bioenergetic failure. This led some to consider using ketone bodies to enhance AD brain bioenergetics and treat AD. Objective: We evaluated the rate at which brain homogenates from persons with Alzheimer’s disease (AD) metabolize D-β-hydroxybutyrate (BHB). Methods: We homogenized pieces of temporal cortex from frozen autopsy brains obtained from recently deceased AD subjects (n = 4), and age-matched subjects that did not have clinical AD (n = 3). Measuring the rate of CO2 producti

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Kibayashi, Kazuhiko, Paul M. Ng’walali, Martin P. Mbonde, et al. "Neuropathology of Human Immunodeficiency Virus 1 Infection." Archives of Pathology & Laboratory Medicine 123, no. 6 (1999): 519–23. http://dx.doi.org/10.5858/1999-123-0519-nohivi.

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Abstract Objective.—In sub-Saharan Africa, only a few studies of neurologic complications of human immunodeficiency virus 1 (HIV-1) infection have been done. The authors studied neuropathology of HIV-1 infection in Tanzania. Design.—Forensic autopsy study at Dar es Salaam, Tanzania. Setting.—A joint research project between Dar es Salaam, Tanzania, and Kumamoto, Japan. Patients.—Thirty patients with risk factors for HIV-1 infection. Main Outcome Measures.—Human immunodeficiency virus 1 infection was evaluated by HIV-1 antibody test on postmortem serum samples. The brains of HIV-1–infected pers

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Salami, A., M. Ajani, I. Orhorho, et al. "Brain weights in adult africans." Journal of Morphological Sciences 34, no. 04 (2017): 223–25. http://dx.doi.org/10.4322/jms.106316.

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Abstract Introduction: The average brain weight of adult humans, using Caucasian figures, is said to be between 1300g to 1400g. Few studies have however been done to make actual evaluations of brain weights in adult Africans. This study seeks to examine the weight of brains from people of African descent with respect to variations in sex and age in decades using autopsy specimens. Materials and Methods: Analysis of the weight of brains removed from both male and female adult patients during fresh autopsy of their bodies in our center over a ten year period was done. The study criteria required

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Kandel, Jwala, and Dikshanta Pokharel. "Mean Brain Weight among Autopsy Cases at the Department of Forensic Medicine of a Tertiary Care Centre: A Descriptive Cross-sectional Study." Journal of Nepal Medical Association 60, no. 247 (2022): 274–77. http://dx.doi.org/10.31729/jnma.7162.

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Introduction: Weight of the brain is an important diagnostic criterion during autopsy. Normal variations in brain weight among various population demands for population-specific study. The aim of this study was to find the mean brain weight among autopsy cases at a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among autopsy cases in the Department of Forensic Medicine of a tertiary care hospital from July 2019 to July 2021. The approval for the study was obtained from the Institutional Review Committee (Reference number: 550/2019). Convenience sampling was do

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Klinken, L., and P. Arlien-Søborg. "Brain autopsy in organic solvent syndrome." Acta Neurologica Scandinavica 87, no. 5 (2009): 371–75. http://dx.doi.org/10.1111/j.1600-0404.1993.tb04120.x.

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Provias, John, and Brian Jeynes. "Immunohistochemical Detection of Receptor-Associated Protein in Normal Human Brain and Alzheimer's Disease." Pathology Research International 2010 (December 20, 2010): 1–5. http://dx.doi.org/10.4061/2010/173496.

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This study is one of the few to characterize immunohistochemically the distribution and localization of Receptor-Associated Protein (RAP) in human autopsy brain. The results show prominent cortical neuronal localization. RAP is clearly identified in large neuronal dendritic/axonal processes. RAP is expressed in both large pyramidal and smaller interneurons. Occasional, much less frequent RAP is detectable in glial cells in white matter, which appear to be predominantly astrocytic. Although RAP is detectable immunohistochemically in Alzheimer's disease autopsy brain, the level of expression app

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Carlos, Durão H., Veiga G. Marcos, Nina Pedro, Gonçalves M. Manuela, and Frederico Pedrosa. "Sudden death associated with melanoma brain metastases." Journal of Pathology of Nepal 8, no. 2 (2018): 1412–15. http://dx.doi.org/10.3126/jpn.v8i2.20896.

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A 48-year-old male Caucasian, with no relevant medical history except for a mild depression, was found by the partner, passed out on the bedroom floor. Since he was found in cardiac arrest, cardiopulmonary resuscitation was attempted, without success. Initially, it was suspected to be a suicide attempt and autopsy findings revealed coronary atherosclerosis of about 40%, with no other recoverable cardiac findings.The brain showed multiple probable neoplastic lesions, associated with cerebral and cerebellar hemorrhage. The primary tumor was not identified, but the victim had multiple cutaneous n

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Conces, Miriam R., Anna Hughes, and Christopher R. Pierson. "Neuropathology of Mowat–Wilson Syndrome." Pediatric and Developmental Pathology 23, no. 4 (2020): 322–25. http://dx.doi.org/10.1177/1093526620903956.

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Mowat–Wilson syndrome (MWS) is a syndromic form of Hirschsprung disease that is characterized by variable degrees of intellectual disability, characteristic facial dysmorphism, and a diverse set of other congenital malformations due to haploinsufficiency of ZEB2. A variety of brain malformations have been described in neuroimaging studies of MWS patients, and the role of ZEB2 in the brain has been studied in a multitude of genetically engineered mouse models that are now available. However, a paucity of autopsy information limits our ability to correlate data from neuroimaging studies and anim

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Sonnemans, Lianne J. P., Bela Kubat, Mathias Prokop, and Willemijn M. Klein. "Can virtual autopsy with postmortem CT improve clinical diagnosis of cause of death? A retrospective observational cohort study in a Dutch tertiary referral centre." BMJ Open 8, no. 3 (2018): e018834. http://dx.doi.org/10.1136/bmjopen-2017-018834.

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ObjectiveTo investigate whether virtual autopsy with postmortem CT (PMCT) improves clinical diagnosis of the immediate cause of death.DesignRetrospective observational cohort study. Inclusion criteria: inhospital and out-of-hospital deaths over the age of 1 year in whom virtual autopsy with PMCT and conventional autopsy were performed. Exclusion criteria: forensic cases, postmortal organ donors and cases with incomplete scanning procedures. Cadavers were examined by virtual autopsy with PMCT prior to conventional autopsy. The clinically determined cause of death was recorded before virtual aut

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Minami, Seigo, Hideyasu Okada, Shoichi Ihara, Hiromi Tsuji, Misaki Yamadera, and Hironao Yasuoka. "Pembrolizumab-Induced Meningoencephalitis: A Brain Autopsy Case." Journal of Medical Cases 12, no. 9 (2021): 359–65. http://dx.doi.org/10.14740/jmc3748.

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Taherian, Mehran, Joseph Jones, Caroline Williams, Linda Duque, and Deborah C. Mash. "Brain biomarkers of alcohol abuse at autopsy." Drug and Alcohol Dependence 146 (January 2015): e114. http://dx.doi.org/10.1016/j.drugalcdep.2014.09.678.

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Scott, Ian Stuart, and Alastair Wray MacDonald. "An evaluation of overnight fixation to facilitate neuropathological examination in Coroner's autopsies: our experience of over 200 cases." Journal of Clinical Pathology 66, no. 1 (2012): 50–53. http://dx.doi.org/10.1136/jclinpath-2012-200839.

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AimsFollowing recent changes in Coroner's Rules, there has been a desire to examine brains at the time of autopsy, rather than after a prolonged period of immersion fixation. Examination of the fresh brain at postmortem can yield unsatisfactory results where detailed histological examination is required. We aim to provide a compromise, where detailed examination of the brain is possible, without the requirement for prolonged fixation, interference with funeral arrangements and delay in the Coronial process.MethodsA retrospective audit of over 200 neuropathology cases requested by HM Coroner fo

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Soleimani-Meigooni, David N., Leonardo Iaccarino, Renaud La Joie, et al. "18F-flortaucipir PET to autopsy comparisons in Alzheimer’s disease and other neurodegenerative diseases." Brain 143, no. 11 (2020): 3477–94. http://dx.doi.org/10.1093/brain/awaa276.

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Abstract Few studies have evaluated the relationship between in vivo18F-flortaucipir PET and post-mortem pathology. We sought to compare antemortem 18F-flortaucipir PET to neuropathology in a consecutive series of patients with a broad spectrum of neurodegenerative conditions. Twenty patients were included [mean age at PET 61 years (range 34–76); eight female; median PET-to-autopsy interval of 30 months (range 4–59 months)]. Eight patients had primary Alzheimer’s disease pathology, nine had non-Alzheimer tauopathies (progressive supranuclear palsy, corticobasal degeneration, argyrophilic grain

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Rajput, Ali H., and Alex Rajput. "Saskatchewan Movement Disorders Program." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 42, no. 2 (2015): 74–87. http://dx.doi.org/10.1017/cjn.2015.13.

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AbstractWe review the Saskatchewan Movement Disorders Program, which started in 1968 and has had the dual goals of patient care and research. The clinics are structured to collect research-worthy data including videos, longitudinal follow-up, and autopsy studies of patients seen in the clinics. At every clinic visit, the patient is evaluated by one or both authors. A total of 25% to 30% of the deceased come to autopsy. Frozen half-brain and formalin-fixed remnants from autopsy are preserved in our laboratories. Patients not seen in our clinic are not included in research, which makes it differ

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Konakov, A. S., Yu S. Brikova, and E. M. Koludarova. "Method of autopsy study of thalamus and basal nuclei." Forensic Medical Expertise 68, no. 3 (2025): 43. https://doi.org/10.17116/sudmed20256803143.

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Thalamus and basal nuclei are deep structures of the brain which play a crucial role in regulating consciousness level. Traumatic injuries in them occur in craniocerebral injury (CCI), post-traumatic alterations — at the 2nd stage of dislocation syndrome. Non-traumatic hemorrhages are most often located in these structures. The existing methods of the brain autopsy study have not been effective enough for their focused detailed examination. Objective. To develop the rational and effective method of thalamus and basal nuclei autopsy examination for identification of pathomorphological changes a

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Bigio, Eileen H. "Making the Diagnosis of Frontotemporal Lobar Degeneration." Archives of Pathology & Laboratory Medicine 137, no. 3 (2013): 314–25. http://dx.doi.org/10.5858/arpa.2012-0075-ra.

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Context.—Autopsy evaluation of the brain of a patient with frontotemporal dementia (FTD) can be daunting to the general pathologist. At some point in their training, most pathologists learn about Pick disease, and can recognize Pick bodies, the morphologic hallmark of Pick disease. Pick disease is a type of frontotemporal lobar degeneration (FTLD), the general category of pathologic process underlying most cases of FTD. The 2 major categories of pathologic FTLD are tauopathies (FTLD-tau) and ubiquitinopathies (FTLD-U). Pick disease is one of the FTLD-tau subtypes and is termed FTLD-tau (PiD).

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DESAI, A., S. K. SHANKAR, P. N. JAYAKUMAR, et al. "Co-existence of cerebral cysticercosis with Japanese encephalitis: a prognostic modulator." Epidemiology and Infection 118, no. 2 (1997): 165–71. http://dx.doi.org/10.1017/s0950268896007327.

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In this study, we investigated the frequency of co-existence of cerebral cysticercosis (CC) in Japanese encephalitis (JE) cases with special emphasis on its role in predicting the final clinical outcome. Amongst the 163 confirmed cases of JE, 37·42% (61/163) had co-existent CC. This was confirmed by antibody detection in the CSF of 45 cases, CT scan of the brain in 6 cases and at autopsy in 3 cases. In 2 cases confirmation was possible by CT scan as well as at autopsy, in 4, CSF antibody levels and CT scan were suggestive of CC while in 1, CSF antibodies and autopsy were suggestive of CC. The

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Cohen, Marta C., Martyn N. Paley, Paul D. Griffiths, and Elspeth H. Whitby. "Less Invasive Autopsy: Benefits and Limitations of the Use of Magnetic Resonance Imaging in the Perinatal Postmortem." Pediatric and Developmental Pathology 11, no. 1 (2008): 1–9. http://dx.doi.org/10.2350/07-01-0213.1.

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The decline in the postmortem (PM) autopsy rate in the United Kingdom paralleled the change in public perception of this procedure after the organ retention crisis in 2000. The introduction of magnetic resonance imaging (MRI) in the fetal, perinatal, and pediatric autopsy led some investigators to propose that MRI could replace the conventional PM. We assessed the role of MRI in fetal autopsy as an addition or a potential replacement method to the conventional PM and to evaluate the benefits and limitations of each technique. We retrospectively reviewed the PM and MRI examination of 100 fetuse

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Fullerton, Josie L., Jennifer Hay, Charlotte Bryant-Craig, Josephine Atkinson, Douglas H. Smith, and William Stewart. "Pediatric Traumatic Brain Injury and Microvascular Blood-Brain Barrier Pathology." JAMA Network Open 7, no. 11 (2024): e2446767. http://dx.doi.org/10.1001/jamanetworkopen.2024.46767.

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ImportancePediatric traumatic brain injury (TBI) is a major cause of morbidity and mortality, with an increased risk of catastrophic outcome compared with adult TBI, including diffuse brain swelling and so-called second impact syndrome. Nevertheless, the biological substrates driving adverse outcomes in pediatric TBI remain poorly described.ObjectiveTo compare neuropathological evidence of brain swelling and blood-brain barrier (BBB) disruption after moderate or severe acute TBI in adult vs pediatric case material.Design, Setting, and ParticipantsIn this retrospective case series, cases of ped

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Wright-Nadkarni, Mariah, Megan Schaefer, Emily Moscato, et al. "EOLP-01. PROPOSED FRAMEWORK FOR A PILOT MULTIDISCIPLINARY BEREAVEMENT FOLLOW-UP AND BRAIN AUTOPSY REVIEW FOR BEREAVED CAREGIVERS IN PEDIATRIC NEURO-ONCOLOGY." Neuro-Oncology 26, Supplement_8 (2024): viii137. http://dx.doi.org/10.1093/neuonc/noae165.0535.

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Abstract INTRODUCTION Brain tumors remain the leading cause of cancer-related death in children. The death of a child is distressing for caregivers and often associated with negative psychosocial outcomes. Bereaved caregivers frequently desire ongoing support after their child’s death. At our institution, brain autopsies with the option for tissue donation to research are offered to all families after the death of a child. Specific follow-up conducted to date and review of autopsy results have varied widely. We propose a pilot study to (1) evaluate feasibility of a comprehensive, multidiscipli

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Diaconescu, Ioana, Sorin Hostiuc, and George Cristian Curca. "Brain Banking – Bioethical Implications." Studia Universitatis Babeş-Bolyai Bioethica 66, Special Issue (2021): 68. http://dx.doi.org/10.24193/subbbioethica.2021.spiss.39.

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"Novel biotechnologies like brain banking pose a challenge in neurodegenerative diseases research, being not only a step towards a better understanding for these diseases, but also from a bioethical point of view. Brain banks collect tissue for research purposes from deceased persons suffering from neurodegenerative diseases such as Parkinson’s or Alzheimes’s disease. In order to improve the quality in this research field, confidentiality and a detailed informed consent are aspects that should be emphasized. Moreover, given the fact that the brain collecting takes place during an autopsy, lega

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Kinako, Sam Ewune, Narugayam Claudius Izein, kelachi Thankgod Wala, and Obioha Solomon. "Acute Pyogenic Meningitis: An Autopsy Case Report." International Multispeciality Journal of Health 9, no. 1 (2023): 11–14. https://doi.org/10.5281/zenodo.7590042.

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<strong>Abstract</strong><strong>—</strong> Acute pyogenic meningitis may be complicated by tonsillar herniation and this makes the clinical management of the patient very arduous and may to death. We report a case of a 13-year-old female admitted to the children emergency unit due to meningitis secondary to lobar pneumonia. The autopsy showed central cyanosis, lobar pneumonia, cerebral oedema, exudate around the brain, cerebral oedema and tonsillar herniation. Brain smear revealed numerous gram-positive cocci in chains. The cause of death was tonsillar herniation secondary to acute pyog

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Bhatia, Ravjot Singh, and Jasvinder Kaur Bhatia. "Neurological Involvement in Dengue: An Autopsy Study." Medical Journal of Dr. D.Y. Patil Vidyapeeth 17, no. 2 (2023): 485–88. http://dx.doi.org/10.4103/mjdrdypu.mjdrdypu_840_22.

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ABSTRACT Dengue is a mosquito-borne disease that is a public health concern and outbreaks have increased in India. The virus produces fever, hemorrhagic fever, and shock syndrome. Dengue may cause encephalopathy. Few autopsies in individuals with neurological complaints have been documented. Our paper reports on an adult with dengue and neurological symptoms with postmortem findings. Thirty-six-year-old presented with a 2-day fever. He was febrile with a normal systemic exam. By evening, he was stuporous. His platelet count was moderately decreased to about 80,000/cumm. His serum and cerebrosp

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Hooshmand, Babak, Tuomo Polvikoski, Miia Kivipelto, et al. "Plasma homocysteine, Alzheimer and cerebrovascular pathology: a population-based autopsy study." Brain 136, no. 9 (2013): 2707–16. http://dx.doi.org/10.1093/brain/awt206.

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TAMURA, Masaru, Chihiro OHYE, and Yoichi NAKAZATO. "Pathological Anatomy of Autopsy Brain with Malignant Glioma." Neurologia medico-chirurgica 33, no. 2 (1993): 77–80. http://dx.doi.org/10.2176/nmc.33.77.

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Mori, S., N. H. Sternberger, M. M. Herman, and L. A. Sternberger. "Variability of laminin immunoreactivity in human autopsy brain." Histochemistry 97, no. 3 (1992): 237–41. http://dx.doi.org/10.1007/bf00267633.

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Chatzaraki, Vasiliki, Stephan A. Bolliger, Michael J. Thali, Sebastian Eggert, and Thomas D. Ruder. "Unexpected brain finding in pre-autopsy postmortem CT." Forensic Science, Medicine and Pathology 13, no. 3 (2017): 367–71. http://dx.doi.org/10.1007/s12024-017-9880-7.

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Riederer, P., M. Weiser, I. Wichart, et al. "Preliminary brain autopsy findings in progredient rett syndrome." American Journal of Medical Genetics 25, S1 (1986): 305–15. http://dx.doi.org/10.1002/ajmg.1320250530.

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Jenkins, H. G., and H. S. Bachelard. "Glycosaminoglycans in Cortical Autopsy Samples from Alzheimer Brain." Journal of Neurochemistry 51, no. 5 (1988): 1641–45. http://dx.doi.org/10.1111/j.1471-4159.1988.tb01135.x.

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Galbatsov, D. F., M. B. Borisenko, N. N. Soloviev, A. M. Emelin, and R. V. Deev. "Autopsy observations of sporadic Creutzfeldt-Jakob disease." CLINICAL AND EXPERIMENTAL MORPHOLOGY 14, no. 3 (2025): 80–85. https://doi.org/10.31088/cem2025.14.3.80-85.

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Introduction. Creutzfeldt-Jakob disease is a fatal neurodegenerative disorder caused by deposited prion protein in neurons, which is resistant to human cell proteases. This disease manifests as polymorphic neurological symptoms, progressive dementia, and impaired breathing and swallowing. The fatal outcome is observed within 6–12 months. Postmortem morphological examination reveals spongiform degeneration of brain tissue, neuronophagia, and amyloid-like protein conglomerates. This paper describescharacteristic changes identified on histological examination of brain tissue of a patient with Cre

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IOV, Tatiana, Cristina FURNICĂ, Sofia Mihaela DAVID, and Diana BULGARU-ILIESCU. "Medical, Forensic and Social Quandaries of Sudden Infant Death Syndrome Today." BRAIN. Broad Research in Artificial Intelligence and Neuroscience 11, no. 3 Sup.1 (2020): 20–30. https://doi.org/10.18662/brain/11.3Sup1/118.

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 Sudden Infant Death Syndrome (SIDS) is described as thesudden, unexplained death (with no attributable cause, during sleep) of aseemingly healthy child before reaching the first year of life. Statistically,SIDS is recognized today as a leading cause of death in infants aged 1 to12 months. In the present article the authors have analyzed known riskfactors, classifications and current standards of forensic investigation whilehighlighting the necessity of detailed clinical history, autopsy, scene ofdeath examination and lab findings (radiology, metabolic anomalies,infectious diseases and to

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Castañeyra-Perdomo, Agustin, Jose Luis Gonzalez-Mora, Emilia Maria Carmona-Calero, Nikos Makris, and Jose Luis Carrasco-Juan. "A Narrative Review on the Clinical Relevance of Imaging the Circumventricular Brain Organs and Performing Their Anatomical and Histopathological Examination in Acute and Postacute COVID-19." American Journal of Forensic Medicine & Pathology 45, no. 2 (2024): 151–56. http://dx.doi.org/10.1097/paf.0000000000000939.

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Abstract Autopsy followed by histopathological examination is foundational in clinical and forensic medicine for discovering and understanding pathological changes in disease, their underlying processes, and cause of death. Imaging technology has become increasingly important for advancing clinical research and practice, given its noninvasive, in vivo and ex vivo applicability. Medical and forensic autopsy can benefit greatly from advances in imaging technology that lead toward minimally invasive, whole-brain virtual autopsy. Brain autopsy followed by histopathological examination is still the

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Dumitrescu, Logan, Lisa L. Barnes, Madhav Thambisetty, et al. "Sex differences in the genetic predictors of Alzheimer’s pathology." Brain 142, no. 9 (2019): 2581–89. http://dx.doi.org/10.1093/brain/awz206.

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Abstract Autopsy measures of Alzheimer’s disease neuropathology have been leveraged as endophenotypes in previous genome-wide association studies (GWAS). However, despite evidence of sex differences in Alzheimer’s disease risk, sex-stratified models have not been incorporated into previous GWAS analyses. We looked for sex-specific genetic associations with Alzheimer’s disease endophenotypes from six brain bank data repositories. The pooled dataset included 2701 males and 3275 females, the majority of whom were diagnosed with Alzheimer’s disease at autopsy (70%). Sex-stratified GWAS were perfor

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Solomon, David A., Huimin Geng, Raymond A. Sobel, Lakshmi Subbaraj, Mazie Tsang, and James L. Rubenstein. "Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies." Blood 134, Supplement_1 (2019): 1494. http://dx.doi.org/10.1182/blood-2019-131302.

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While the genomic landscape of CNS lymphomas at diagnosis has largely been defined, there remains a significant gap in our understanding of the molecular pathways that mediate therapeutic resistance and disease progression. CNS lymphomas generally exhibit multifocal dissemination as an end-stage manifestation. To elucidate key genetic and pathophysiologic pathways of CNS lymphoma that mediate resistance, we have conducted what may be the first study to apply next generation sequencing to compare the genetic features of PCNSL and SCNSL at the time of diagnosis with multifocal lesions isolated f

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Reed, B. R., D. M. Mungas, J. H. Kramer, et al. "Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease." Brain 130, no. 3 (2007): 731–39. http://dx.doi.org/10.1093/brain/awl385.

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Del Ser, Teodoro, Vladimir Hachinski, Harold Merskey, and David G. Munoz. "An autopsy-verified study of the effect of education on degenerative dementia." Brain 122, no. 12 (1999): 2309–19. http://dx.doi.org/10.1093/brain/122.12.2309.

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Iov, Tatiana, Cristina Furnică, Sofia Mihaela David, and Diana Bulgaru-Iliescu. "Medical, Forensic and Social Quandaries of Sudden Infant Death Syndrome Today." BRAIN. Broad Research in Artificial Intelligence and Neuroscience 11, no. 3sup1 (2020): 20–30. http://dx.doi.org/10.18662/brain/11.3sup1/118.

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Sudden Infant Death Syndrome (SIDS) is described as the sudden, unexplained death (with no attributable cause, during sleep) of a seemingly healthy child before reaching the first year of life. Statistically, SIDS is recognized today as a leading cause of death in infants aged 1 to 12 months. In the present article the authors have analyzed known risk factors, classifications and current standards of forensic investigation while highlighting the necessity of detailed clinical history, autopsy, scene of death examination and lab findings (radiology, metabolic anomalies, infectious diseases and

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Meryem, Karima, and Mustafa Yussef. "The Role of Enzymatic Molecular Autopsy for Law Enforcement in Cyanide Poisoning Cases in Rabat, Morocco." Sriwijaya Journal of Forensic and Medicolegal 2, no. 1 (2024): 66–72. http://dx.doi.org/10.59345/sjfm.v2i1.125.

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Introduction: Cyanide poisoning is a serious public health problem throughout the world, including in Morocco. Enzymatic molecular autopsy offers a powerful method for detecting and quantifying cyanide levels in body tissue, which can assist law enforcement in poisoning cases. Methods: This observational study was conducted on 112 research subjects who died from cyanide poisoning in Rabat, Morocco. An enzymatic molecular autopsy was performed to measure cyanide levels in the blood, liver, and brain. Data were analyzed to determine the relationship between cyanide levels and demographic, clinic

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Shannon, P., J. R. Wherrett, and S. Nag. "A Rare Form of Adult Onset Leukodystrophy: Orthochromatic Leukodystrophy with Pigmented Glia." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 24, no. 2 (1997): 146–50. http://dx.doi.org/10.1017/s0317167100021491.

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ABSTRACT:Background:Orthochromatic leukodystrophy with pigmented glia and scavenger cells is a rare leukodystrophy of unknown etiology. This report describes a 42-year-old man with a history of depression, dementia and parkinsonism having the pathological features of orthochromatic leukodystrophy with pigmented glia.Methods:We reviewed the clinical history and pathology of autopsy and brain biopsy material.Results:Imaging revealed bilateral cerebral white matter hypodensities. At autopsy, the brain demonstrated a leukodystrophy affecting predominantly the cerebral hemispheres and characterized

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Flach, Patricia M., Steffen G. Ross, Stephan A. Bolliger, Ulrich S. Preiss, Michael J. Thali, and Danny Spendlove. "Postmortem Whole-Body Computed Tomography Angiography Visualizing Vascular Rupture in a Case of Fatal Car Crash." Archives of Pathology & Laboratory Medicine 134, no. 1 (2010): 115–19. http://dx.doi.org/10.5858/2008-0503-crr3.1.

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Abstract In addition to the increasingly significant role of multislice computed tomography in forensic pathology, the performance of whole-body computed tomography angiography provides outstanding results. In this case, we were able to detect multiple injuries of the parenchymal organs in the upper abdomen as well as lesions of the brain parenchyma and vasculature of the neck. The radiologic findings showed complete concordance with the autopsy and even supplemented the autopsy findings in areas that are difficult to access via a manual dissection (such as the vasculature of the neck). This c

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Oakley, Derek H., Mirra Chung, Naomi Klickstein, Caitlin Commins, Bradley T. Hyman та Matthew P. Frosch. "The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue". Journal of Neuropathology & Experimental Neurology 79, № 6 (2020): 592–604. http://dx.doi.org/10.1093/jnen/nlaa025.

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Abstract Familial Alzheimer disease-causing mutations in Presenilin 1 (PSEN1) are generally thought to shift the processing of APP toward longer, more amyloidogenic Aβ fragments. However, certain PSEN1 mutations cause severe reduction in gamma secretase function when expressed in the homozygous state, thus challenging the amyloid hypothesis. We sought to evaluate the effects of one such mutation, PSEN1 L435F, in more physiologic conditions and genetic contexts by using human induced pluripotent stem cell (iPSC)-derived neurons from an individual with familial AD (fAD) linked to the PSEN1 L435F

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BIGLER, ERIN D. "Neuropsychological results and neuropathological findings at autopsy in a case of mild traumatic brain injury." Journal of the International Neuropsychological Society 10, no. 5 (2004): 794–806. http://dx.doi.org/10.1017/s1355617704105146.

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Autopsy studies were undertaken in a 47-year-old college-educated male patient who, 7 months prior to an unexpected death, had sustained a mild traumatic brain injury (TBI) as manifested by brief loss of consciousness and an initial Glasgow Coma Scale score of 14. The patient died from cardiac arrest secondary to an undiagnosed and unknown arteriosclerotic cardiovascular disease as assessed by the coroner's office at the time of autopsy. Gross inspection of the brain at autopsy was normal; however, microscopic analysis demonstrated what were considered trauma findings of hemosiderin-laden macr

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Ahmed, Samrah, Anne-Marie F. Haigh, Celeste A. de Jager, and Peter Garrard. "Connected speech as a marker of disease progression in autopsy-proven Alzheimer’s disease." Brain 136, no. 12 (2013): 3727–37. http://dx.doi.org/10.1093/brain/awt269.

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Hynd, Matthew R., Joanne M. Lewohl, Heather L. Scott, and Peter R. Dodd. "Biochemical and molecular studies using human autopsy brain tissue." Journal of Neurochemistry 85, no. 3 (2003): 543–62. http://dx.doi.org/10.1046/j.1471-4159.2003.01747.x.

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Burke, C. J. "Prenatal ischaemic brain injury and placental infarction: Autopsy studies." Placenta 19, no. 8 (1998): 683–84. http://dx.doi.org/10.1016/s0143-4004(98)90035-2.

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Niizato, Kazuhiro, Tetsuaki Arai, Noriomi Kuroki, Koichi Kase, Shuji Iritani, and Kenji Ikeda. "Autopsy study of Alzheimer's disease brain pathology in schizophrenia." Schizophrenia Research 31, no. 2-3 (1998): 177–84. http://dx.doi.org/10.1016/s0920-9964(98)00028-0.

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Burke, Christopher J., and Anthony E. Tannenberg. "PRENATAL BRAIN DAMAGE AND PLACENTAL INFARCTION -AN AUTOPSY STUDY." Developmental Medicine & Child Neurology 37, no. 6 (2008): 555–62. http://dx.doi.org/10.1111/j.1469-8749.1995.tb12042.x.

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Ansari, Mohammed Q., Carol A. Chincanchan, and Dawna L. Armstrong. "Brain calcification in hypoxic-ischemic lesions: An autopsy review." Pediatric Neurology 6, no. 2 (1990): 94–101. http://dx.doi.org/10.1016/0887-8994(90)90041-x.

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Jang, Jinhyeok, Minhwa Kim, Yangsuk Park, Jeongrim Lee, and Insung Moon. "P3.6: Analysis of autopsy cases of brain death subjects." Transplantation 107, no. 10S1 (2023): 86. http://dx.doi.org/10.1097/01.tp.0000993508.87760.27.

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Nair, Govind, Roy Sun, Hellmut Merkle, et al. "A method to image brain tissue frozen at autopsy." NeuroImage 296 (August 2024): 120680. http://dx.doi.org/10.1016/j.neuroimage.2024.120680.

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