Log in

Relevant bibliographies by topics / Auxiliary channels / Journal articles

To see the other types of publications on this topic, follow the link: Auxiliary channels.

Journal articles on the topic 'Auxiliary channels'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Auxiliary channels.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Dvorak, Nolan M., Paul A. Wadsworth, Pingyuan Wang, Jia Zhou, and Fernanda Laezza. "Development of Allosteric Modulators of Voltage-Gated Na+ Channels: A Novel Approach for an Old Target." Current Topics in Medicinal Chemistry 21, no. 10 (2021): 841–48. http://dx.doi.org/10.2174/1568026621666210525105359.

Full text

Abstract:

Given their primacy in governing the action potential (AP) of excitable cells, voltage-gated Na+ (Nav) channels are important pharmacological targets of therapeutics for a diverse array of clinical indications. Despite historically being a traditional drug target, therapeutics targeting Nav channels lack isoform selectivity, giving rise to off-target side effects. To develop isoform-selective modulators of Nav channels with improved target-specificity, the identification and pharmacological targeting of allosteric sites that display structural divergence among Nav channel isoforms represents a

APA, Harvard, Vancouver, ISO, and other styles

2

Flockerzi, Veit, and Bernd Fakler. "TR(i)P Goes On: Auxiliary TRP Channel Subunits?" Circulation Research 134, no. 4 (2024): 346–50. http://dx.doi.org/10.1161/circresaha.123.323178.

Full text

Abstract:

Transient receptor potential (TRP) cation channels are a diverse family of channels whose members play prominent roles as cellular sensors and effectors. The important role of TRP channels (and mechanosensitive piezo channels) in the complex interaction of our senses with the environment was underlined by the award of the Nobel Prize in Physiology or Medicine to 2 pioneers in this field, David Julius and Ardem Patapoutian. There are many competent and comprehensive reviews on many aspects of the TRP channels, and there is no intention to expand on them. Rather, after an introduction to the nom

APA, Harvard, Vancouver, ISO, and other styles

3

Hoshi, Toshinori, Rong Xu, Shangwei Hou, Stefan H. Heinemann, and Yutao Tian. "A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid." Journal of General Physiology 142, no. 5 (2013): 507–22. http://dx.doi.org/10.1085/jgp.201311061.

Full text

Abstract:

Long-chain polyunsaturated omega-3 fatty acids such as docosahexaenoic acid (DHA) at nanomolar concentrations reversibly activate human large-conductance Ca2+- and voltage-gated K+ (Slo1 BK) channels containing auxiliary β1 or β4 subunits in cell-free patches. Here we examined the action of DHA on the Slo1 channel without any auxiliary subunit and sought to elucidate the biophysical mechanism and the molecular determinants of the DHA sensitivity. Measurements of ionic currents through human Slo1 (hSlo1) channels reveal that the stimulatory effect of DHA does not require activation of the volta

APA, Harvard, Vancouver, ISO, and other styles

4

Zhou, Zijing, Xiaonuo Ma, Yiechang Lin, et al. "MyoD-family inhibitor proteins act as auxiliary subunits of Piezo channels." Science 381, no. 6659 (2023): 799–804. http://dx.doi.org/10.1126/science.adh8190.

Full text

Abstract:

Piezo channels are critical cellular sensors of mechanical forces. Despite their large size, ubiquitous expression, and irreplaceable roles in an ever-growing list of physiological processes, few Piezo channel–binding proteins have emerged. In this work, we found that MyoD (myoblast determination)–family inhibitor proteins (MDFIC and MDFI) are PIEZO1/2 interacting partners. These transcriptional regulators bind to PIEZO1/2 channels, regulating channel inactivation. Using single-particle cryogenic electron microscopy, we mapped the interaction site in MDFIC to a lipidated, C-terminal helix that

APA, Harvard, Vancouver, ISO, and other styles

5

Jones, Lisa P., Shao-kui Wei та David T. Yue. "Mechanism of Auxiliary Subunit Modulation of Neuronal α1E Calcium Channels". Journal of General Physiology 112, № 2 (1998): 125–43. http://dx.doi.org/10.1085/jgp.112.2.125.

Full text

Abstract:

Voltage-gated calcium channels are composed of a main pore-forming α1 moiety, and one or more auxiliary subunits (β, α2δ) that modulate channel properties. Because modulatory properties may vary greatly with different channels, expression systems, and protocols, it is advantageous to study subunit regulation with a uniform experimental strategy. Here, in HEK 293 cells, we examine the expression and activation gating of α1E calcium channels in combination with a β (β1–β4) and/or the α2δ subunit, exploiting both ionic- and gating-current measurements. Furthermore, to explore whether more than on

APA, Harvard, Vancouver, ISO, and other styles

6

Jiao, Yunjing, Qijing Lin, Kun Yao, et al. "Design of High-Precision Parallel AWG Demodulation System." Micromachines 14, no. 9 (2023): 1662. http://dx.doi.org/10.3390/mi14091662.

Full text

Abstract:

Here, we present a high-precision demodulation method that supports the arrayed waveguide grating (AWG) system, which includes a 1 × 8 AWG as the primary filter with a 0.5 nm channel spacing and a 1 × 4 AWG as the auxiliary filter with a 1 nm channel spacing. The high precision is achieved through an innovative method of decoupling three channels, involving two adjacent channels of the primary filter and one channel of the secondary auxiliary filter. Simulation results show that the AWGs have a good transmission spectrum with crosstalk below −24.8 dB, non-uniformities below 0.8 dB, insertion l

APA, Harvard, Vancouver, ISO, and other styles

7

Dvorak, Nolan M., Cynthia M. Tapia, Aditya K. Singh, et al. "Pharmacologically Targeting the Fibroblast Growth Factor 14 Interaction Site on the Voltage-Gated Na+ Channel 1.6 Enables Isoform-Selective Modulation." International Journal of Molecular Sciences 22, no. 24 (2021): 13541. http://dx.doi.org/10.3390/ijms222413541.

Full text

Abstract:

Voltage-gated Na+ (Nav) channels are the primary molecular determinant of the action potential. Among the nine isoforms of the Nav channel α subunit that have been described (Nav1.1-Nav1.9), Nav1.1, Nav1.2, and Nav1.6 are the primary isoforms expressed in the central nervous system (CNS). Crucially, these three CNS Nav channel isoforms display differential expression across neuronal cell types and diverge with respect to their subcellular distributions. Considering these differences in terms of their localization, the CNS Nav channel isoforms could represent promising targets for the developme

APA, Harvard, Vancouver, ISO, and other styles

8

Sinha, Ashish, Haodong Gu, Namwoon Kim, and Renu Emile. "Signaling effects and the role of culture: movies in international auxiliary channels." European Journal of Marketing 53, no. 10 (2019): 2146–72. http://dx.doi.org/10.1108/ejm-09-2017-0587.

Full text

Abstract:

Purpose Given the high uncertainty in the quality perception of experiential products, manufacturers use signals to influence consumers’ decisions. In the movie industry, literature shows that performance of the main channel (e.g. cinema) strongly influences the performance of auxiliary channels (e.g. DVDs). The success of a movie in the home country is also to be resonated by its good performance in host countries. However, the cultural contingency of these success-breeds-success (SBS) effects has not been examined. This paper aims to test the influence of cultural values on the SBS effects a

APA, Harvard, Vancouver, ISO, and other styles

9

Brown, Austin L., Zhiwen Liao, and Miriam B. Goodman. "MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity." Journal of General Physiology 131, no. 6 (2008): 605–16. http://dx.doi.org/10.1085/jgp.200709910.

Full text

Abstract:

The ion channel formed by the homologous proteins MEC-4 and MEC-10 forms the core of a sensory mechanotransduction channel in Caenorhabditis elegans. Although the products of other mec genes are key players in the biophysics of transduction, the mechanism by which they contribute to the properties of the channel is unknown. Here, we investigate the role of two auxiliary channel subunits, MEC-2 (stomatin-like) and MEC-6 (paraoxonase-like), by coexpressing them with constitutively active MEC-4/MEC-10 heteromeric channels in Xenopus oocytes. This work extends prior work demonstrating that MEC-2 a

APA, Harvard, Vancouver, ISO, and other styles

10

Williams, Brittany, Josue A. Lopez, J. Wesley Maddox, and Amy Lee. "Functional impact of a congenital stationary night blindness type 2 mutation depends on subunit composition of Cav1.4 Ca2+ channels." Journal of Biological Chemistry 295, no. 50 (2020): 17215–26. http://dx.doi.org/10.1074/jbc.ra120.014138.

Full text

Abstract:

Voltage-gated Cav1 and Cav2 Ca2+ channels are comprised of a pore-forming α1 subunit (Cav1.1-1.4, Cav2.1-2.3) and auxiliary β (β1-4) and α2δ (α2δ−1−4) subunits. The properties of these channels vary with distinct combinations of Cav subunits and alternative splicing of the encoding transcripts. Therefore, the impact of disease-causing mutations affecting these channels may depend on the identities of Cav subunits and splice variants. Here, we analyzed the effects of a congenital stationary night blindness type 2 (CSNB2)-causing mutation, I745T (IT), in Cav1.4 channels typical of those in human

APA, Harvard, Vancouver, ISO, and other styles

11

Dolphin, Annette C. "Voltage-gated calcium channels: Their discovery, function and importance as drug targets." Brain and Neuroscience Advances 2 (January 2018): 239821281879480. http://dx.doi.org/10.1177/2398212818794805.

Full text

Abstract:

This review will first describe the importance of Ca2+ entry for function of excitable cells, and the subsequent discovery of voltage-activated calcium conductances in these cells. This finding was rapidly followed by the identification of multiple subtypes of calcium conductance in different tissues. These were initially termed low- and high-voltage activated currents, but were then further subdivided into L-, N-, PQ-, R- and T-type calcium currents on the basis of differing pharmacology, voltage-dependent and kinetic properties, and single channel conductance. Purification of skeletal muscle

APA, Harvard, Vancouver, ISO, and other styles

12

Kramer, Gerhard. "Information Rates for Channels with Fading, Side Information and Adaptive Codewords." Entropy 25, no. 5 (2023): 728. http://dx.doi.org/10.3390/e25050728.

Full text

Abstract:

Generalized mutual information (GMI) is used to compute achievable rates for fading channels with various types of channel state information at the transmitter (CSIT) and receiver (CSIR). The GMI is based on variations of auxiliary channel models with additive white Gaussian noise (AWGN) and circularly-symmetric complex Gaussian inputs. One variation uses reverse channel models with minimum mean square error (MMSE) estimates that give the largest rates but are challenging to optimize. A second variation uses forward channel models with linear MMSE estimates that are easier to optimize. Both mo

APA, Harvard, Vancouver, ISO, and other styles

13

Tian, Yutao, Florian Ullrich, Rong Xu, Stefan H. Heinemann, Shangwei Hou, and Toshinori Hoshi. "Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels." Journal of General Physiology 145, no. 4 (2015): 331–43. http://dx.doi.org/10.1085/jgp.201511363.

Full text

Abstract:

Phosphatidylinositol 4,5-bisphosphate (PIP2) plays a critical role in modulating the function of numerous ion channels, including large-conductance Ca2+- and voltage-dependent K+ (BK, Slo1) channels. Slo1 BK channel complexes include four pore-forming Slo1 (α) subunits as well as various regulatory auxiliary subunits (β and γ) that are expressed in different tissues. We examined the molecular and biophysical mechanisms underlying the effects of brain-derived PIP2 on human Slo1 BK channel complexes with different subunit compositions that were heterologously expressed in human embryonic kidney

APA, Harvard, Vancouver, ISO, and other styles

14

Gandini, María A., Alejandro Sandoval, Ricardo González-Ramírez, Yasuo Mori, Michel de Waard, and Ricardo Felix. "Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release." Journal of Biological Chemistry 286, no. 18 (2011): 15757–65. http://dx.doi.org/10.1074/jbc.m110.187757.

Full text

Abstract:

Insulin release by pancreatic β-cells is regulated by diverse intracellular signals, including changes in Ca2+ concentration resulting from Ca2+ entry through voltage-gated (CaV) channels. It has been reported that the Rab3 effector RIM1 acts as a functional link between neuronal CaV channels and the machinery for exocytosis. Here, we investigated whether RIM1 regulates recombinant and native L-type CaV channels (that play a key role in hormone secretion) and whether this regulation affects insulin release. Whole-cell patch clamp currents were recorded from HEK-293 and insulinoma RIN-m5F cells

APA, Harvard, Vancouver, ISO, and other styles

15

Malloy, Cole, Maisie Ahern, Lin Lin, and Dax A. Hoffman. "Neuronal Roles of the Multifunctional Protein Dipeptidyl Peptidase-like 6 (DPP6)." International Journal of Molecular Sciences 23, no. 16 (2022): 9184. http://dx.doi.org/10.3390/ijms23169184.

Full text

Abstract:

The concerted action of voltage-gated ion channels in the brain is fundamental in controlling neuronal physiology and circuit function. Ion channels often associate in multi-protein complexes together with auxiliary subunits, which can strongly influence channel expression and function and, therefore, neuronal computation. One such auxiliary subunit that displays prominent expression in multiple brain regions is the Dipeptidyl aminopeptidase-like protein 6 (DPP6). This protein associates with A-type K+ channels to control their cellular distribution and gating properties. Intriguingly, DPP6 ha

APA, Harvard, Vancouver, ISO, and other styles

16

Xu, Jia, and Min Li. "Auxiliary Subunits of Shaker-type Potassium Channels." Trends in Cardiovascular Medicine 8, no. 5 (1998): 229–34. http://dx.doi.org/10.1016/s1050-1738(98)00011-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Isom, L. "Auxiliary subunits of voltage-gated ion channels." Neuron 12, no. 6 (1994): 1183–94. http://dx.doi.org/10.1016/0896-6273(94)90436-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Li, Qin, Xin Guan, Karen Yen, Jiyuan Zhang та Jiusheng Yan. "The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit". Journal of General Physiology 147, № 4 (2016): 337–51. http://dx.doi.org/10.1085/jgp.201511551.

Full text

Abstract:

The large-conductance, calcium-activated potassium (BK) channels consist of the pore-forming, voltage- and Ca2+-sensing α subunits (BKα) and the tissue-specific auxiliary β and γ subunits. The BK channel γ1 subunit is a leucine-rich repeat (LRR)–containing membrane protein that potently facilitates BK channel activation in many tissues and cell types through a vast shift in the voltage dependence of channel activation by ∼140 mV in the hyperpolarizing direction. In this study, we found that the single transmembrane (TM) segment together with its flanking charged residues is sufficient to fully

APA, Harvard, Vancouver, ISO, and other styles

19

Felix, Ricardo, Alejandra Corzo-Lopez, and Alejandro Sandoval. "Voltage-Gated Ion Channels in Neuropathic Pain Signaling." Life 15, no. 6 (2025): 888. https://doi.org/10.3390/life15060888.

Full text

Abstract:

Neuropathic pain is a chronic and debilitating disorder of the somatosensory system that affects a significant proportion of the population and is characterized by abnormal responses such as hyperalgesia and allodynia. Voltage-gated ion channels, including sodium (NaV), calcium (CaV), and potassium (KV) channels, play a pivotal role in modulating neuronal excitability and pain signal transmission following nerve injury. This review intends to provide a comprehensive analysis of the molecular and cellular mechanisms by which dysregulation in the expression, localization, and function of specifi

APA, Harvard, Vancouver, ISO, and other styles

20

Tong, Mingjie, and R. Keith Duncan. "Tamoxifen inhibits BK channels in chick cochlea without alterations in voltage-dependent activation." American Journal of Physiology-Cell Physiology 297, no. 1 (2009): C75—C85. http://dx.doi.org/10.1152/ajpcell.00659.2008.

Full text

Abstract:

Large-conductance, Ca2+-activated, and voltage-gated potassium channels (BK, BKCa, or Maxi-K) play an important role in electrical tuning in nonmammalian vertebrate hair cells. Systematic changes in tuning frequency along the tonotopic axis largely result from variations in BK channel kinetics, but the molecular changes underpinning these functional variations remain unknown. Auxiliary β1 have been implicated in low-frequency tuning at the cochlear apex because these subunits dramatically slow channel kinetics. Tamoxifen (Tx), a (xeno)estrogen compound known to activate BK channels through the

APA, Harvard, Vancouver, ISO, and other styles

21

Vacher, Hélène, Jae-Won Yang, Oscar Cerda, Amapola Autillo-Touati, Bénédicte Dargent та James S. Trimmer. "Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting". Journal of Cell Biology 192, № 5 (2011): 813–24. http://dx.doi.org/10.1083/jcb.201007113.

Full text

Abstract:

Kv1 channels are concentrated at specific sites in the axonal membrane, where they regulate neuronal excitability. Establishing these distributions requires regulated dissociation of Kv1 channels from the neuronal trafficking machinery and their subsequent insertion into the axonal membrane. We find that the auxiliary Kvβ2 subunit of Kv1 channels purified from brain is phosphorylated on serine residues 9 and 31, and that cyclin-dependent kinase (Cdk)–mediated phosphorylation at these sites negatively regulates the interaction of Kvβ2 with the microtubule plus end–tracking protein EB1. Endogeno

APA, Harvard, Vancouver, ISO, and other styles

22

Jespersen, Thomas, Morten Grunnet, and Søren-Peter Olesen. "The KCNQ1 Potassium Channel: From Gene to Physiological Function." Physiology 20, no. 6 (2005): 408–16. http://dx.doi.org/10.1152/physiol.00031.2005.

Full text

Abstract:

The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.

APA, Harvard, Vancouver, ISO, and other styles

23

Carrillo, Elba D., Juan A. Alvarado, Ascención Hernández, Ivonne Lezama, María C. García та Jorge A. Sánchez. "Thyroid Hormone Upregulates Cav1.2 Channels in Cardiac Cells via the Downregulation of the Channels’ β4 Subunit". International Journal of Molecular Sciences 25, № 19 (2024): 10798. http://dx.doi.org/10.3390/ijms251910798.

Full text

Abstract:

Thyroid hormone binds to specific nuclear receptors, regulating the expression of target genes, with major effects on cardiac function. Triiodothyronine (T3) increases the expression of key proteins related to calcium homeostasis, such as the sarcoplasmic reticulum calcium ATPase pump, but the detailed mechanism of gene regulation by T3 in cardiac voltage-gated calcium (Cav1.2) channels remains incompletely explored. Furthermore, the effects of T3 on Cav1.2 auxiliary subunits have not been investigated. We conducted quantitative reverse transcriptase polymerase chain reaction, Western blot, an

APA, Harvard, Vancouver, ISO, and other styles

24

Sun, Wenhao, Yuchen He, Tianfeng Yan, Zhongdong Wu, and Yide Ma. "Training of Deep Joint Transmitter-Receiver Optimized Communication System without Auxiliary Tools." Electronics 13, no. 5 (2024): 831. http://dx.doi.org/10.3390/electronics13050831.

Full text

Abstract:

Deep Joint transmitter-receiver optimized communication system (Deep JTROCS) is a new physical layer communication system. It integrates the functions of various signal processing blocks into deep neural networks in the transmitter and receiver. Therefore, Deep JTROCS can approach the optimal state at the system level by the joint training of these neural networks. However, due to the non-differentiable feature of the channel, the back-propagation of Deep JTROCS training gradients is hindered which hinders the training of the neural networks in the transmitter. Although researchers have propos

APA, Harvard, Vancouver, ISO, and other styles

25

Gurnett, Christina A., and Kevin P. Campbell. "Transmembrane Auxiliary Subunits of Voltage-dependent Ion Channels." Journal of Biological Chemistry 271, no. 45 (1996): 27975–78. http://dx.doi.org/10.1074/jbc.271.45.27975.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Mohler, Peter J., and Xander H. T. Wehrens. "Mechanisms of Human Arrhythmia Syndromes: Abnormal Cardiac Macromolecular Interactions." Physiology 22, no. 5 (2007): 342–50. http://dx.doi.org/10.1152/physiol.00018.2007.

Full text

Abstract:

Many cardiac ion channels exist within macromolecular signaling complexes, comprised of pore-forming subunits that associate with auxiliary subunits, regulatory enzymes, and targeting proteins. This complex protein assembly ensures proper modulation of channel activity and ion homeostasis. The association of genetic defects in regulatory and targeting proteins to inherited arrhythmia syndromes has led to a better understanding of the critical role these proteins play in ion channel modulation.

APA, Harvard, Vancouver, ISO, and other styles

27

Vacher, Helene, Durga P. Mohapatra, and James S. Trimmer. "Localization and Targeting of Voltage-Dependent Ion Channels in Mammalian Central Neurons." Physiological Reviews 88, no. 4 (2008): 1407–47. http://dx.doi.org/10.1152/physrev.00002.2008.

Full text

Abstract:

The intrinsic electrical properties and the synaptic input-output relationships of neurons are governed by the action of voltage-dependent ion channels. The localization of specific populations of ion channels with distinct functional properties at discrete sites in neurons dramatically impacts excitability and synaptic transmission. Molecular cloning studies have revealed a large family of genes encoding voltage-dependent ion channel principal and auxiliary subunits, most of which are expressed in mammalian central neurons. Much recent effort has focused on determining which of these subunits

APA, Harvard, Vancouver, ISO, and other styles

28

Peng, Bo, Wenyi Zhang, Yuxin Hu, Qingwei Chu, and Qianqian Li. "LRFFNet: Large Receptive Field Feature Fusion Network for Semantic Segmentation of SAR Images in Building Areas." Remote Sensing 14, no. 24 (2022): 6291. http://dx.doi.org/10.3390/rs14246291.

Full text

Abstract:

There are limited studies on the semantic segmentation of high-resolution synthetic aperture radar (SAR) images in building areas due to speckle noise and geometric distortion. For this challenge, we propose the large receptive field feature fusion network (LRFFNet), which contains a feature extractor, a cascade feature pyramid module (CFP), a large receptive field channel attention module (LFCA), and an auxiliary branch. SAR images only contain single-channel information and have a low signal-to-noise ratio. Using only one level of features extracted by the feature extractor will result in po

APA, Harvard, Vancouver, ISO, and other styles

29

Han, Ye, Kyle Lyman, Matt Clutter, et al. "Identification of Small-Molecule Inhibitors of Hyperpolarization-Activated Cyclic Nucleotide–Gated Channels." Journal of Biomolecular Screening 20, no. 9 (2015): 1124–31. http://dx.doi.org/10.1177/1087057115589590.

Full text

Abstract:

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels function in the brain to limit neuronal excitability. Limiting the activity of these channels has been proposed as a therapy for major depressive disorder, but the critical role of HCN channels in cardiac pacemaking has limited efforts to develop therapies directed at the channel. Previous studies indicated that the function of HCN is tightly regulated by its auxiliary subunit, tetratricopeptide repeat–containing Rab8b interacting protein (TRIP8b), which is not expressed in the heart. To target the function of the HCN channel i

APA, Harvard, Vancouver, ISO, and other styles

30

Ancatén-González, Carlos, Ignacio Segura, Rosangelina Alvarado-Sánchez, Andrés E. Chávez, and Ramon Latorre. "Ca2+- and Voltage-Activated K+ (BK) Channels in the Nervous System: One Gene, a Myriad of Physiological Functions." International Journal of Molecular Sciences 24, no. 4 (2023): 3407. http://dx.doi.org/10.3390/ijms24043407.

Full text

Abstract:

BK channels are large conductance potassium channels characterized by four pore-forming α subunits, often co-assembled with auxiliary β and γ subunits to regulate Ca2+ sensitivity, voltage dependence and gating properties. BK channels are abundantly expressed throughout the brain and in different compartments within a single neuron, including axons, synaptic terminals, dendritic arbors, and spines. Their activation produces a massive efflux of K+ ions that hyperpolarizes the cellular membrane. Together with their ability to detect changes in intracellular Ca2+ concentration, BK channels contro

APA, Harvard, Vancouver, ISO, and other styles

31

Qin, Ning, Riccardo Olcese, Enrico Stefani та Lutz Birnbaumer. "Modulation of human neuronal α1E-type calcium channel by α2δ-subunit". American Journal of Physiology-Cell Physiology 274, № 5 (1998): C1324—C1331. http://dx.doi.org/10.1152/ajpcell.1998.274.5.c1324.

Full text

Abstract:

Calcium channels are composed of a pore-forming subunit, α1, and at least two auxiliary subunits, β- and α2δ-subunits. It is well known that β-subunits regulate most of the properties of the channel. The function of α2δ-subunit is less understood. In this study, the effects of the calcium channel α2δ-subunit on the neuronal α1E voltage-gated calcium channel expressed in Xenopus oocytes was investigated without and with simultaneous coexpression of either the β1b- or the β2a-subunit. Most aspects of α1E function were affected by α2δ. Thus α2δ caused a shift in the current-voltage and conductanc

APA, Harvard, Vancouver, ISO, and other styles

32

Hoshi, T., A. Pantazis, and R. Olcese. "Transduction of Voltage and Ca2+ Signals by Slo1 BK Channels." Physiology 28, no. 3 (2013): 172–89. http://dx.doi.org/10.1152/physiol.00055.2012.

Full text

Abstract:

Large-conductance Ca2+- and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism.

APA, Harvard, Vancouver, ISO, and other styles

33

Dshalalow, Jewgeni. "On a multi-channel transportation loss system with controlled input and controlled service." Journal of Applied Mathematics and Simulation 1, no. 1 (1987): 41–55. http://dx.doi.org/10.1155/s1048953388000048.

Full text

Abstract:

A multi-channel loss queueing system is investigated. The input stream is a controlled point process. The service in each of m parallel channels depends on the state of the system at certain moments of time when input and service may be controlled. To obtain explicitly the limiting distribution of the main process (Zt) (the number of busy channels) in equilibrium, an auxiliary three dimensional process with two additional components (one of them is a semi-Markov process) is treated as semi-regenerative process. An optimization problem is discussed. Simple expressions for an objective function

APA, Harvard, Vancouver, ISO, and other styles

34

Cohen, Risa M., Jason D. Foell, Ravi C. Balijepalli, Vaibhavi Shah, Johannes W. Hell та Timothy J. Kamp. "Unique modulation of L-type Ca2+ channels by short auxiliary β1d subunit present in cardiac muscle". American Journal of Physiology-Heart and Circulatory Physiology 288, № 5 (2005): H2363—H2374. http://dx.doi.org/10.1152/ajpheart.00348.2004.

Full text

Abstract:

Recent studies have identified a growing diversity of splice variants of auxiliary Ca2+ channel Cavβ subunits. The Cavβ1d isoform encodes a putative protein composed of the amino-terminal half of the full-length Cavβ1 isoform and thus lacks the known high-affinity binding site that recognizes the Ca2+ channel α1-subunit, the α-binding pocket. The present study investigated whether the Cavβ1d subunit is expressed at the protein level in heart, and whether it exhibits any of the functional properties typical of full-length Cavβ subunits. On Western blots, an antibody directed against the unique

APA, Harvard, Vancouver, ISO, and other styles

35

Dolphin, Annette C. "Voltage-gated calcium channel α2δ subunits: an assessment of proposed novel roles". F1000Research 7 (21 листопада 2018): 1830. http://dx.doi.org/10.12688/f1000research.16104.1.

Full text

Abstract:

Voltage-gated calcium (CaV) channels are associated with β and α2δ auxiliary subunits. This review will concentrate on the function of the α2δ protein family, which has four members. The canonical role for α2δ subunits is to convey a variety of properties on the CaV1 and CaV2 channels, increasing the density of these channels in the plasma membrane and also enhancing their function. More recently, a diverse spectrum of non-canonical interactions for α2δ proteins has been proposed, some of which involve competition with calcium channels for α2δ or increase α2δ trafficking and others which media

APA, Harvard, Vancouver, ISO, and other styles

36

Pancaroglu, Raika, and Filip Van Petegem. "Calcium Channelopathies: Structural Insights into Disorders of the Muscle Excitation–Contraction Complex." Annual Review of Genetics 52, no. 1 (2018): 373–96. http://dx.doi.org/10.1146/annurev-genet-120417-031311.

Full text

Abstract:

Ion channels are membrane proteins responsible for the passage of ions down their electrochemical gradients and across biological membranes. In this, they generate and shape action potentials and provide secondary messengers for various signaling pathways. They are often part of larger complexes containing auxiliary subunits and regulatory proteins. Channelopathies arise from mutations in the genes encoding ion channels or their associated proteins. Recent advances in cryo-electron microscopy have resulted in an explosion of ion channel structures in multiple states, generating a wealth of new

APA, Harvard, Vancouver, ISO, and other styles

37

Zhao, Juan, Michael E. O'Leary та Mohamed Chahine. "Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits". Journal of Neurophysiology 106, № 2 (2011): 608–19. http://dx.doi.org/10.1152/jn.00107.2011.

Full text

Abstract:

Voltage-gated Na+ (Nav) channels are composed of a pore-forming α-subunit and one or more auxiliary β-subunits. The present study investigated the regulation by the β-subunit of two Na+ channels (Nav1.6 and Nav1.8) expressed in dorsal root ganglion (DRG) neurons. Single cell RT-PCR was used to show that Nav1.8, Nav1.6, and β1–β3 subunits were widely expressed in individually harvested small-diameter DRG neurons. Coexpression experiments were used to assess the regulation of Nav1.6 and Nav1.8 by β-subunits. The β1-subunit induced a 2.3-fold increase in Na+ current density and hyperpolarizing sh

APA, Harvard, Vancouver, ISO, and other styles

38

Brown, Patricia M. G. E., Hugo McGuire, and Derek Bowie. "Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation." Journal of General Physiology 150, no. 1 (2017): 67–82. http://dx.doi.org/10.1085/jgp.201711895.

Full text

Abstract:

Most ligand- and voltage-gated ion channels assemble as signaling complexes consisting of pore-forming and auxiliary subunits. In the mammalian brain, AMPA-type ionotropic glutamate receptors (AMPARs) coassemble with several families of auxiliary subunits that regulate channel gating as well as ion channel block and permeation. Previous work has shown that auxiliary proteins stargazin (or γ2) and cornichon-3 (CNIH-3) attenuate the cytoplasmic polyamine channel block of AMPARs, although the underlying mechanism has yet to be established. Here, we show that γ2 and CNIH-3 relieve channel block by

APA, Harvard, Vancouver, ISO, and other styles

39

He, Yanjun, and Jianhua Li. "Stress Distribution and Optimum Spacing Determination of Double-Withdrawal-Channel Surrounding Rocks: A Case Study of Chinese Coal Mine." Shock and Vibration 2021 (July 3, 2021): 1–16. http://dx.doi.org/10.1155/2021/9973634.

Full text

Abstract:

In this study, the 31113 fully mechanised working face in the Lijiahao Coal Mine was selected as the project background. The failure characteristics and optimum spacing of a double-withdrawal-channel surrounding rock were extensively investigated through field measurements, theoretical analysis, and numerical simulations. The following results were obtained. The loading influence range of the working face was fixed. Under the influence of mining, the stress distribution variation in the double-withdrawal channels with spacing and the influence of stress distribution on the surrounding rock sta

APA, Harvard, Vancouver, ISO, and other styles

40

Sek, Aleksandra, Rafal P. Kampa, Bogusz Kulawiak, Adam Szewczyk, and Piotr Bednarczyk. "Identification of the Large-Conductance Ca2+-Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells." Molecules 26, no. 11 (2021): 3233. http://dx.doi.org/10.3390/molecules26113233.

Full text

Abstract:

Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane. Several hypotheses have been proposed to describe the important roles of mitochondrial potassium channels in cell survival and death pathways. In the current study, we identified two populations of mitochondrial large-conductance Ca2+-regulated potassium (mitoBKCa) channels in human bronchial epithelial (HBE) cells. The biophysical properties of the channels were character

APA, Harvard, Vancouver, ISO, and other styles

41

Cheng, Hao-Chung, and Min-Hsiu Hsieh. "Concavity of the Auxiliary Function for Classical-Quantum Channels." IEEE Transactions on Information Theory 62, no. 10 (2016): 5960–65. http://dx.doi.org/10.1109/tit.2016.2598835.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Andreozzi, Assunta, Oronzio Manca, and Vincenzo Naso. "Natural convection in vertical channels with an auxiliary plate." International Journal of Numerical Methods for Heat & Fluid Flow 12, no. 6 (2002): 716–34. http://dx.doi.org/10.1108/09615530210438364.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Garcia, M. L., H. G. Knaus, P. Munujos, R. S. Slaughter, and G. J. Kaczorowski. "Charybdotoxin and its effects on potassium channels." American Journal of Physiology-Cell Physiology 269, no. 1 (1995): C1—C10. http://dx.doi.org/10.1152/ajpcell.1995.269.1.c1.

Full text

Abstract:

Over the last few years, a considerable amount of information has been obtained regarding K+ channels. Different areas of research have contributed to knowledge in this field. Charybdotoxin (ChTX), a 37-amino acid peptide isolated from venom of the scorpion Leiurus quinquestriatus var. hebraeus, represents a remarkable tool for studying K+ channels. With its use, it has been possible to purify the high-conductance Ca(2+)-activated K+ (maxi-K) channel to homogeneity and determine the subunit composition of this channel. This has led to the discovery of an auxiliary beta-subunit that, when coexp

APA, Harvard, Vancouver, ISO, and other styles

44

Bao, Lin, та Daniel H. Cox. "Gating and Ionic Currents Reveal How the BKCa Channel's Ca2+ Sensitivity Is Enhanced by its β1 Subunit". Journal of General Physiology 126, № 4 (2005): 393–412. http://dx.doi.org/10.1085/jgp.200509346.

Full text

Abstract:

Large-conductance Ca2+-activated K+ channels (BKCa channels) are regulated by the tissue-specific expression of auxiliary β subunits. β1 is predominately expressed in smooth muscle, where it greatly enhances the BKCa channel's Ca2+ sensitivity, an effect that is required for proper regulation of smooth muscle tone. Here, using gating current recordings, macroscopic ionic current recordings, and unitary ionic current recordings at very low open probabilities, we have investigated the mechanism that underlies this effect. Our results may be summarized as follows. The β1 subunit has little or no

APA, Harvard, Vancouver, ISO, and other styles

45

Brager, Darrin H., Alan S. Lewis, Dane M. Chetkovich, and Daniel Johnston. "Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b." Journal of Neurophysiology 110, no. 10 (2013): 2350–57. http://dx.doi.org/10.1152/jn.00218.2013.

Full text

Abstract:

Hyperpolarization-activated cyclic nucleotide-gated nonselective cation channels (HCN or h-channels) are important regulators of neuronal physiology contributing to passive membrane properties, such as resting membrane potential and input resistance ( RN), and to intrinsic oscillatory activity and synaptic integration. The correct membrane targeting of h-channels is regulated in part by the auxiliary h-channel protein TRIP8b. The genetic deletion of TRIP8b results in a loss of functional h-channels, which affects the postsynaptic integrative properties of neurons. We investigated the impact of

APA, Harvard, Vancouver, ISO, and other styles

46

Guntur, Divya, Horst Olschewski, Péter Enyedi, Réka Csáki, Andrea Olschewski, and Chandran Nagaraj. "Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation." Biomolecules 11, no. 11 (2021): 1629. http://dx.doi.org/10.3390/biom11111629.

Full text

Abstract:

Potassium ion concentrations, controlled by ion pumps and potassium channels, predominantly govern a cell′s membrane potential and the tone in the vessels. Calcium-activated potassium channels respond to two different stimuli-changes in voltage and/or changes in intracellular free calcium. Large conductance calcium-activated potassium (BKCa) channels assemble from pore forming and various modulatory and auxiliary subunits. They are of vital significance due to their very high unitary conductance and hence their ability to rapidly cause extreme changes in the membrane potential. The pathophysio

APA, Harvard, Vancouver, ISO, and other styles

47

Maqoud, Fatima, Michela Cetrone, Antonietta Mele, and Domenico Tricarico. "Molecular structure and function of big calcium-activated potassium channels in skeletal muscle: pharmacological perspectives." Physiological Genomics 49, no. 6 (2017): 306–17. http://dx.doi.org/10.1152/physiolgenomics.00121.2016.

Full text

Abstract:

The large-conductance Ca2+-activated K+ (BK) channel is broadly expressed in various mammalian cells and tissues such as neurons, skeletal muscles (sarco-BK), and smooth muscles. These channels are activated by changes in membrane electrical potential and by increases in the concentration of intracellular calcium ion (Ca2+). The BK channel is subjected to many mechanisms that add diversity to the BK channel α-subunit gene. These channels are indeed subject to alternative splicing, auxiliary subunits modulation, posttranslational modifications, and protein-protein interactions. BK channels can

APA, Harvard, Vancouver, ISO, and other styles

48

Zuo, Hao, Ian Glaaser, Yulin Zhao, et al. "Structural basis for auxiliary subunit KCTD16 regulation of the GABABreceptor." Proceedings of the National Academy of Sciences 116, no. 17 (2019): 8370–79. http://dx.doi.org/10.1073/pnas.1903024116.

Full text

Abstract:

Metabotropic GABABreceptors mediate a significant fraction of inhibitory neurotransmission in the brain. Native GABABreceptor complexes contain the principal subunits GABAB1and GABAB2, which form an obligate heterodimer, and auxiliary subunits, known as potassium channel tetramerization domain-containing proteins (KCTDs). KCTDs interact with GABABreceptors and modify the kinetics of GABABreceptor signaling. Little is known about the molecular mechanism governing the direct association and functional coupling of GABABreceptors with these auxiliary proteins. Here, we describe the high-resolution

APA, Harvard, Vancouver, ISO, and other styles

49

Chen, Zijing, and Craig Montell. "A Family of Auxiliary Subunits of the TRP Cation Channel Encoded by the Complex inaF Locus." Genetics 215, no. 3 (2020): 713–28. http://dx.doi.org/10.1534/genetics.120.303268.

Full text

Abstract:

TRP channels function in many types of sensory receptor cells. Despite extensive analyses, an open question is whether there exists a family of auxiliary subunits, which could influence localization, trafficking, and function of TRP channels. Here, using Drosophila melanogaster, we reveal a previously unknown TRP interacting protein, INAF-C, which is expressed exclusively in the ultraviolet-sensing R7 photoreceptor cells. INAF-C is encoded by an unusual locus comprised of four distinct coding regions, which give rise to four unique single-transmembrane-containing proteins. With the exception o

APA, Harvard, Vancouver, ISO, and other styles

50

Zeng, Xu-Hui, J. P. Ding, Xiao-Ming Xia та Christopher J. Lingle. "Gating Properties Conferred on Bk Channels by the β3b Auxiliary Subunit in the Absence of Its Nh2- and Cooh Termini". Journal of General Physiology 117, № 6 (2001): 607–28. http://dx.doi.org/10.1085/jgp.117.6.607.

Full text

Abstract:

Both β1 and β2 auxiliary subunits of the BK-type K+ channel family profoundly regulate the apparent Ca2+ sensitivity of BK-type Ca2+-activated K+ channels. Each produces a pronounced leftward shift in the voltage of half-activation (V0.5) at a given Ca2+ concentration, particularly at Ca2+ above 1 μM. In contrast, the rapidly inactivating β3b auxiliary produces a leftward shift in activation at Ca2+ below 1 μM. In the companion work (Lingle, C.J., X.-H. Zeng, J.-P. Ding, and X.-M. Xia. 2001. J. Gen. Physiol. 117:583–605, this issue), we have shown that some of the apparent β3b-mediated shift i

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!