Academic literature on the topic 'Average blood flow'

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Journal articles on the topic "Average blood flow"

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Srinivasan, Vivek J., and Harsha Radhakrishnan. "Total average blood flow and angiography in the rat retina." Journal of Biomedical Optics 18, no. 7 (2013): 076025. http://dx.doi.org/10.1117/1.jbo.18.7.076025.

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Twardowski, Z. J., and J. D. Haynie. "Measurements of Hemodialysis Catheter Blood Flow in Vivo." International Journal of Artificial Organs 25, no. 4 (2002): 276–80. http://dx.doi.org/10.1177/039139880202500405.

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The relationship between the blood flow and inflow and outflow pressures was determined in PermCath, dual lumen catheters during regular hemodialyses in vivo in eight patients with average hematocrit of 38%. From the luer lock connector the catheters had an average length of 32 cm to the outflow tip and 30 cm to the inflow tip. The catheters had an internal diameter of 0.2 cm and were straight before implantation. Dialyses were performed on Fresenius 2008 D or E machines with ReadySet™ blood lines with an 8 mm ID pump segment and a noncollapsible arterial chamber. Pressures and blood flows wer
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Finol, Ender A., and Cristina H. Amon. "Blood Flow in Abdominal Aortic Aneurysms: Pulsatile Flow Hemodynamics." Journal of Biomechanical Engineering 123, no. 5 (2001): 474–84. http://dx.doi.org/10.1115/1.1395573.

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Numerical predictions of blood flow patterns and hemodynamic stresses in Abdominal Aortic Aneurysms (AAAs) are performed in a two-aneurysm, axisymmetric, rigid wall model using the spectral element method. Physiologically realistic aortic blood flow is simulated under pulsatile conditions for the range of time-averaged Reynolds numbers 50⩽Rem⩽300, corresponding to a range of peak Reynolds numbers 262.5⩽Repeak⩽1575. The vortex dynamics induced by pulsatile flow in AAAs is characterized by a sequence of five different flow phases in one period of the flow cycle. Hemodynamic disturbance is evalua
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Gabriel, Sargon A., Yan Ding, and Yuqing Feng. "Modelling the period-average transport of species within pulsatile blood flow." Journal of Theoretical Biology 457 (November 2018): 258–69. http://dx.doi.org/10.1016/j.jtbi.2018.07.006.

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Fedorovich, Andrey A., Yulia I. Loktionova, Elena V. Zharkikh, et al. "Body Position Affects Capillary Blood Flow Regulation Measured with Wearable Blood Flow Sensors." Diagnostics 11, no. 3 (2021): 436. http://dx.doi.org/10.3390/diagnostics11030436.

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In this study we demonstrate what kind of relative alterations can be expected in average perfusion and blood flow oscillations during postural changes being measured in the skin of limbs and on the brow of the forehead by wearable laser Doppler flowmetry (LDF) sensors. The aims of the study were to evaluate the dynamics of cutaneous blood perfusion and the regulatory mechanisms of blood microcirculation in the areas of interest, and evaluate the possible significance of those effects for the diagnostics based on blood perfusion monitoring. The study involved 10 conditionally healthy volunteer
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Matta, Fadi, Abdo Yaekoub, Syed Ahsan, et al. "Effect of compression stockings on venous blood velocity and blood flow." Thrombosis and Haemostasis 103, no. 01 (2010): 138–44. http://dx.doi.org/10.1160/th09-06-0365.

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SummaryThe effects of graduated compression stockings (GCS) on venous blood velocity have not been established. In healthy subjects, most investigations showed no effect on blood velocity, but mixed results have been reported. In this investigation we to test the hypothesis that popliteal blood velocity is increased by properly fitted GCS. Time average peak velocity in the popliteal vein, as well as time average mean velocity, vein diameter and mean volumetric flow were measured by pulsed wave Doppler ultrasound in 25 healthy male volunteers without compression stockings and repeated with fitt
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Nabaa, Q. A., and M. A. Mariam. "Study of the Blood Flow average for Atherosclerosis using Ultrasound Doppler shift." Journal of Physics: Conference Series 1963, no. 1 (2021): 012107. http://dx.doi.org/10.1088/1742-6596/1963/1/012107.

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Davie, Peter S., and Craig E. Franklin. "Preliminary observations on blood flow in the coronary arteries of two school sharks (Galeorhinus australis)." Canadian Journal of Zoology 71, no. 6 (1993): 1238–41. http://dx.doi.org/10.1139/z93-169.

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Coronary arterial blood flow and pressure, intraventricular blood pressure, and ventral aortic blood velocity were measured in two anaesthetized school sharks (Galeorhinus australis) in order to examine the phasic relationships between these flows and pressures. Maximum instantaneous flow recorded in the ventral coronary artery was 0.37 mL∙min−1∙kg−1 body mass (estimated 0.63 mL∙min−1∙g−1 ventricular mass). The average mean coronary blood flow was estimated as 0.28 mL∙min−1∙g−1 ventricular mass during periods of high coronary blood flow. On average, 86% of coronary flow occurred during diastol
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Zouache, M. A., I. Eames, and P. J. Luthert. "Blood flow in the choriocapillaris." Journal of Fluid Mechanics 774 (June 2, 2015): 37–66. http://dx.doi.org/10.1017/jfm.2015.243.

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The choriocapillaris is a capillary bed located in a thin layer adjacent to the outer retina and is part of the oxygen delivery system to the photoreceptors of the eye. The blood flow is approximately planar and is serviced by microvessels, which join the choriocapillaris through inlets perpendicular to its plane. Capillaries are densely organised and separated by avascular septal posts, which direct the blood flow. The capillary bed is composed of a juxtaposition of tessellating vascular units called lobules, which are filled and drained independently from each other. A theoretical analysis o
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Tatagiba, Marcos, Shahram Mirzai, and Madjid Samii. "Peritumoral Blood Flow in Intracranial Meningiomas." Neurosurgery 28, no. 3 (1991): 400–404. http://dx.doi.org/10.1227/00006123-199103000-00010.

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Abstract Blood flow was measured in intratumoral tissue, the cerebral hemispheres and particularly in the peritumoral area of 12 patients with intracranial meningiomas using the stable xenon-enhanced computed tomographic scan. Tumor blood flow frequently showed a heterogeneous pattern of enhancement with high flow at the tumor periphery and a central area of hypoperfusion. Blood flow values were on average 28% lower in the peritumoral area than in the ipsilateral cerebral hemisphere. In individual cases, blood flow values in the peritumoral edematous area were very low. These findings suggest
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Dissertations / Theses on the topic "Average blood flow"

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Lerche, Phillip. "Pulmonary blood flow distribution and hypoxic pulmonary vasoconstriction in pentobarbital-anesthetized horses." The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1135278396.

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Books on the topic "Average blood flow"

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Bramham, Kate, and Catherine Nelson-Piercy. Pregnancy and renal physiology. Edited by Norbert Lameire and Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0294_update_001.

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Pregnancy is characterized by unique physiological changes within the kidney, resulting in a marked increase in renal blood flow and glomerular filtration, which are associated with successful pregnancy outcomes. Early in normal pregnancy there are increases in plasma volume and cardiac output, but a lowered peripheral resistance leads to average blood pressures being lower. A pregnancy-associated respiratory alkalosis occurs. Protein excretion tends to increase slightly in women without kidney disease. Kidney size is increased, and pelvicalyceal system dilatation is noticeable in most women i
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Vlachopoulos, Charalambos, and Nikolaos Ioakeimidis. Erectile dysfunction as a marker and predictor of cardiovascular disease. Edited by Charalambos Vlachopoulos. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0245.

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Erectile dysfunction (ED) is defined as the inability to obtain or maintain a penile erection to support satisfactory sexual performance. It is considered an early manifestation of generalized vascular disease and recognized as a marker of increased cardiovascular risk both acutely and chronically by predicting all-cause mortality, cardiovascular mortality, coronary events, stroke, and peripheral artery disease in men with and without known coronary artery disease. The link between ED and cardiovascular disease might reside in the interaction between androgen level, chronic inflammation, and c
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Book chapters on the topic "Average blood flow"

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Fujimura, Miki, and Teiji Tominaga. "Characteristic Pattern of the Cerebral Hemodynamic Changes in the Acute Stage After Combined Revascularization Surgery for Adult Moyamoya Disease: N-isopropyl-p-[123I] iodoamphetamine Single-Photon Emission Computed Tomography Study." In Acta Neurochirurgica Supplement. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63453-7_8.

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AbstractObjective: Surgical revascularization for moyamoya disease (MMD) prevents cerebral ischemic attack by improving cerebral blood flow (CBF) and could also reduce the risk of re-bleeding in hemorrhagic-onset patients. We sought to clarify the cerebral hemodynamic changes in the acute stage after revascularization surgery for adult MMD.Materials and methods: The present study includes 54 consecutive adult patients with MMD (21–76 years old, 43.1 average), undergoing superficial temporal artery-middle cerebral artery anastomosis with indirect pial synangiosis on 65 affected hemispheres. We prospectively performed single-photon emission computed tomography (SPECT) at postoperative day (POD) 1 and 7 of 65 surgeries. Perioperative management was conducted with strict blood pressure control (100–130 mmHg) and minocycline hydrochloride administration.Results: The outcome of 65 surgeries was favorable except for one (1.5%), which manifested as delayed intracerebral hemorrhage due to local hyperperfusion. The postoperative SPECT revealed the characteristic CBF improvement pattern with transient local hyperperfusion (POD1) and subsequent distribution of CBF in wider vascular territory (POD7) on 37 hemispheres (56.9%, 37/65).Conclusion: The revascularization surgery is a safe and effective treatment for adult MMD, while transient local hyperperfusion should be strictly managed by intensive perioperative care.
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Oki, S., Y. Katoh, K. Kurisu, et al. "Effects of Glycerol on Brain Function in Normal Volunteers — Study on Regional Cerebral Blood Flow, Average Topographic EEG and Significance Probability Mapping." In Intracranial Pressure VII. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73987-3_237.

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Magee, Patrick, and Mark Tooley. "Behaviour of Fluids (Liquids and Gases, Flow and Pressure)." In The Physics, Clinical Measurement and Equipment of Anaesthetic Practice for the FRCA. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199595150.003.0011.

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A fluid can be either a liquid or a gas. Fluids exhibit different flow behaviours depending on their physical properties, in particular viscosity and density. Flow characteristics also depend on the geometry of the pipes or channels through which they flow, and on the driving pressure regimes. These principles can be applied to any fluid, and the complexity of the analysis depends on the flow regimes described in this section [Massey 1970]. Fluid flow is generally described as laminar or turbulent. Laminar flow, demonstrated by Osborne Reynolds in 1867, is flow in which laminae or layers of fluid run parallel to each other. In a circular pipe, such as a blood vessel or a bronchus, velocity within the layers nearest the wall of the pipe is least; in the layer immediately adjacent to the wall it is probably actually zero. In fully developed laminar flow, the velocity profile across the pipe is parabolic, as shown in Figure 7.1, and as discussed in Chapter 1. Peak velocity of the fluid occurs in the mid line of the pipe, and is twice the average velocity across the pipe at equilibrium, and layers equidistant from the wall have equal velocity. The importance of laminar flow is that there is minimum energy loss in the flow, i.e. it is an efficient transport mode. This is in contrast to turbulent flow, where eddies and vortices (flow in directions other than the predominant one) mean that energy in fluid transport is wasted in production of heat, additional friction and noise. The result is that the pressure drop required to drive a given flow from one end of the pipe to the other is greater in turbulent than in laminar flow. The shear stress τ, which is the mechanical stress between layers of fluid and between the fluid and the tube wall, is proportional to the velocity gradient across the tube (dv/dr) of the fluid layers. The constant of proportionality between these two variables is the dynamic viscosity, η.
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Schmidt, Kathleen, and Louis Sokoloff. "Computationally Efficient Algorithms for Determining Weighted Average and Gray Matter Cerebral Blood Flow in Heterogeneous Tissues by Positron Emission Tomogr." In Brain Imaging Using PET. Elsevier, 2002. http://dx.doi.org/10.1016/b978-012636651-8/50015-5.

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Vlachopoulos, Charalambos, and Nikolaos Ioakeimidis. "Erectile dysfunction as a marker and predictor of cardiovascular disease." In ESC CardioMed, edited by Charalambos Vlachopoulos. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0245_update_001.

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Erectile dysfunction (ED) is defined as the inability to obtain or maintain a penile erection to support satisfactory sexual performance. It is considered an early manifestation of generalized vascular disease and recognized as a marker of increased cardiovascular risk both acutely and chronically by predicting all-cause mortality, cardiovascular mortality, coronary events, stroke, and peripheral artery disease in men with and without known coronary artery disease. The link between ED and cardiovascular disease might reside in the interaction between androgen level, chronic inflammation, and cardiovascular risk factors that determine endothelial dysfunction and atherosclerosis both in the penile and coronary circulation. Because penile artery size is smaller compared with coronary arteries, the same degree of endothelial dysfunction and atherosclerotic burden causes a more significant reduction of blood flow in erectile tissues compared with that in coronary circulation. From a clinical standpoint, because ED may precede cardiovascular disease, it can be used as an early marker to identify men at higher risk of cardiovascular events. The average 3-year time period between the onset of ED symptoms and a cardiovascular event offers the opportunity for detailed cardiological assessment and intensive treatment of risk factors.
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Farne, Hugo, Edward Norris-Cervetto, and James Warbrick-Smith. "Poor urinary output." In Oxford Cases in Medicine and Surgery. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780198716228.003.0028.

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You should ask the nurse: • What the trend is in urine output—has it been gradually decreasing, or suddenly stopped? If the latter, have they checked if the urinary catheter is blocked by flushing it? This is a rapidly reversible cause of poor urinary output. • What the observations are for the patient. Ask for the heart rate, blood pressure, respiratory rate, oxygen saturations, and temperature, so you can get an idea of how unwell the patient is. This will help you prioritize how soon you need to see the patient. Healthy adults have a urine output of about 1 mL/kg/hour. Oliguria refers to a reduced urine output and is defined variously as <400 mL/day, <0.5 mL/kg/hour, or <30 mL/hour. Anuria refers to the complete absence of urine output. Decreased urine output should be taken very seriously as it may be the first (and only) sign of impending acute renal failure. Untreated, patients may die from hyperkalaemia, profound acidosis, or pulmonary oedema due to the kidneys not performing their usual physiological role. Normal urine output requires: • adequate blood supply to the kidneys • functioning kidneys, and • flow of urine from the kidneys, down the ureters, into the bladder, and out via the urethra. Pathology affecting any of these requirements can result in poor urine output, which is why the differential diagnosis for poor urinary output is often classified as shown in Figure 22.1. In practice, as a junior doctor you want to diagnose and treat the prerenal and postrenal causes. If you come to the conclusion that it is a renal cause (by exclusion), call the renal physicians for an expert opinion. This is crucial in determining the diagnosis: • Adequate intake? Remember that an adult of average size will require about 3 L of fluid intake per 24 hours (30–50 mL/kg/day). Febrile patients will require an extra 500 mL for every 1 °C above 37.0 °C to compensate for increased loss of fluids from evaporation and increased respiratory rate.
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Li, Jie Jack. "Cholesterol." In Triumph of the Heart. Oxford University Press, 2009. http://dx.doi.org/10.1093/oso/9780195323573.003.0007.

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The story of statins starts with cholesterol because statins are a class of drugs that reduce low-density lipoprotein (LDL) cholesterol, the “bad” cholesterol. LDL cholesterol, in turn, is a major risk factor for coronary heart disease, the leading cause of death worldwide and projected to remain so through 2025. About 1.5 million Americans suffer heart attacks each year, and heart disease has emerged as the biggest cause of death in the United States, killing 911,000 people in 2003. Before the 1940s, the average lifespan in America was 47 years, and heart disease did not contribute to mortality to a large extent because people often died of infections. Currently, an average American lives to celebrate her 77th birthday. As a consequence, heart-related disease has risen to be the number one killer. Coronary heart disease manifests in many forms: angina, arrhythmia, atrial fibrillation, congestive heart failure, hypertension, atherosclerosis, myocardial infarction (heart attack), and sudden cardiac death. Atherosclerosis, or blockage in arteries, results when a buildup of cholesterol, inflammatory cells, and fibrous tissue called plaques forms on an artery wall. If these plaques rupture, they can block blood flow to critical organs such as the heart or brain and can lead to heart attack or stroke. Despite the many different forms of cardiovascular disease, the molecule cholesterol is a common denominator for most of them. Therefore, in order to understand coronary heart disease, we first need to take a look at the cholesterol molecule. According to Roman mythology, Janus is the guardian of portals and patron of beginnings and endings. Just like the two-faced Roman god, cholesterol is a double-edged sword for the human body. On the one hand, it is an essential building block for many crucial ingredients the body needs. On the other hand, it can be lethal when it forms plaques on the surface of the arteries and subsequently causes coronary heart disease. Make no mistake, cholesterol is vital to our existence. It is most abundant in our brains—23% of total body cholesterol resides there, making up 1/10th of the solid substance of the brain.
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Gill, Arshpal, Ra’ed Nassar, Ruby Sangha, et al. "Hepatorenal Syndrome." In Advances in Hepatology. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97698.

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Hepatorenal Syndrome (HRS) is an important condition for clinicians to be aware of in the presence of cirrhosis. In simple terms, HRS is defined as a relative rise in creatinine and relative drop in serum glomerular filtration rate (GFR) alongside renal plasma flow (RPF) in the absence of other competing etiologies of acute kidney injury (AKI) in patients with hepatic cirrhosis. It represents the end stage complication of decompensated cirrhosis in the presence of severe portal hypertension, in the absence of prerenal azotemia, acute tubular necrosis or others. It is a diagnosis of exclusion. The recognition of HRS is of paramount importance for clinicians as it carries a high mortality rate and is an indication for transplantation. Recent advances in understanding the pathophysiology of the disease improved treatment approaches, but the overall prognosis remains poor, with Type I HRS having an average survival under 2 weeks. Generally speaking, AKI and renal failure in cirrhotic patients carry a very high mortality rate, with up to 60% mortality rate for patients with renal failure and cirrhosis and 86.6% of overall mortality rates of patients admitted to the intensive care unit. Of the various etiologies of renal failure in cirrhosis, HRS carries a poor prognosis among cirrhotic patients with acute kidney injury. HRS continues to pose a diagnostic challenge. AKI can be either pre-renal, intrarenal or postrenal. Prerenal causes include hypovolemia, infection, use of vasodilators and functional due to decreased blood flow to the kidney, intra-renal such as glomerulopathy, acute tubular necrosis and post-renal such as obstruction. Patients with cirrhosis are susceptible to developing renal impairment. HRS may be classified as Type 1 or rapidly progressive disease, and Type 2 or slowly progressive disease. There are other types of HRS, but this chapter will focus on Type 1 HRS and Type 2 HRS. HRS is considered a functional etiology of acute kidney injury as there is an apparent lack of nephrological parenchymal damage. It is one several possibilities for acute kidney injury in patients with both acute and chronic liver disease. Acute kidney injury (AKI) is one of the most severe complications that could occur with cirrhosis. Up to 50% of hospitalized patients with cirrhosis can suffer from acute kidney injury, and as mentioned earlier an AKI in the presence of cirrhosis in a hospitalized patient has been associated with nearly a 3.5-fold increase in mortality. The definition of HRS will be discussed in this chapter, but it is characterized specifically as a form of acute kidney injury that occurs in patients with advanced liver cirrhosis which results in a reduction in renal blood flow, unresponsive to fluids this occurs in the setting of portal hypertension and splanchnic vasodilation. This chapter will discuss the incidence of HRS, recognizing HRS, focusing mainly on HRS Type I and Type II, recognizing competing etiologies of renal impairment in cirrhotic patients, and the management HRS.
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Conference papers on the topic "Average blood flow"

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N’Dri, Narcisse A., and Don P. Giddens. "Non-Newtonian Blood Flow in the Right Coronary Artery." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-60169.

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Understanding blood flow in the circulatory system and how it affects intimal thickening is important with respect to atherogenesis and also for the design of vascular treatment devices such as stents and arterial grafts. While the assumption of Newtonian blood flow in large arteries is widely accepted by many investigators, questions remain unanswered for blood flow in the coronaries. In this study we investigate Non-Newtonian blood flow behavior in both the right and the left coronaries. We use a commercial code (FIDAP) to compare the Newtonian model to four Non-Newtonian models (Power law,
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Taebi, Amirtahà, Catherine T. Vu, and Emilie Roncali. "Prediction of Blood Flow Distribution in Liver Radioembolization Using Convolutional Neural Networks." In ASME 2020 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/imece2020-24475.

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Abstract We have developed a new dosimetry approach, called CFDose, for liver cancer radioembolization based on computational fluid dynamics (CFD) simulation in the hepatic arterial tree. Although CFDose overcomes some of the limitations of the current dosimetry methods such as the unrealistic assumption of homogeneous distribution of yttrium-90 in the liver, it suffers from the expensive computational cost of CFD simulations. To accelerate CFDose, we introduce a deep learning model to predict the blood flow distribution between the liver segments in a patient with hepatocellular carcinoma. Th
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Xu, Qihang, and Ramesh K. Agarwal. "Blood Flow Simulations of Particle Trapping in Models of Arterial Bifurcations." In ASME 2020 Fluids Engineering Division Summer Meeting collocated with the ASME 2020 Heat Transfer Summer Conference and the ASME 2020 18th International Conference on Nanochannels, Microchannels, and Minichannels. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/fedsm2020-20042.

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Abstract This paper describes the particle trapping mechanism in blood flow in different arterial bifurcation models. For validation of CFD calculations, a T-junction model and a Y-junction model are analyzed. In both the models, there is one inlet pipe with two outlet pipes creating a symmetric bifurcation at some angle from the centerline of the inlet pipe. Naiver-Stokes (RANS) equations are solved for single phase laminar flow using the commercial CFD software ANSYS Fluent. After validation, Eulerian simulations are performed by using the Discrete Phase Model (DPM) for two-phase flow with p
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Finol, Ender A., Shoreh Hajiloo, Keyvan Keyhani, David A. Vorp, and Cristina H. Amon. "Flow-Induced Wall Pressure Under Average Resting Hemodynamic Conditions for Patient-Specific Abdominal Aortic Aneurysms." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32326.

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Abdominal Aortic Aneurysms (AAAs) are characterized by a continuous dilation of the infrarenal segment of the abdominal aorta. Despite significant improvements in surgical procedures and imaging techniques, the mortality and morbidity rates associated with untreated ruptured AAAs are still outrageously high. AAA disease is a health risk of significant importance since this kind of aneurysm is mostly asymptomatic until its rupture, which is frequently a lethal event with an overall mortality rate in the 80% to 90% range. From a purely biomechanical viewpoint, aneurysm rupture is a phenomenon th
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Rose, William C., David Johnson, Justin Spaeth, Jonathan Edwards, and Antony Beris. "Computational and Experimental Investigation of Arterial Hemodynamics." In ASME 2008 International Mechanical Engineering Congress and Exposition. ASMEDC, 2008. http://dx.doi.org/10.1115/imece2008-67860.

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Dynamic arterial blood pressure and blood flow are key determinants of normal or pathological functioning of the cardiovascular system. The measurement of these variables at multiple locations in the body is clinically and physiologically valuable, but difficult to achieve except with invasive methods which carry significant risk to the patient. We have developed and here present a computational model of systemic arterial hemodynamics. The model predicts dynamic pressures and flows throughout the systemic arterial vascular bed. The inputs to the model are pressure or flow measured at a single
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Asiruwa, John J., Aaron M. Propst, and Stephen P. Gent. "Assessing Near-Wall Hemodynamics of Blood Flow in the Left Anterior Descending Segment of the Left Coronary Artery Using Computational Fluid Dynamics." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-71432.

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The objective of this study was to computationally investigate the flow mechanics and the near-wall hemodynamics associated with the different take-off angles in the left coronary artery of the human heart. It is hypothesized that increasing the take-off angles of the left coronary artery will significantly increase or decrease the likelihood of plaque (atherosclerosis) buildup in the left coronary artery bifurcations. Specifically, this study quantified the effects of the varying take-off angles on the branches along the left anterior descending (LAD) of the left coronary artery using computa
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Peiffer, Véronique, Ethan M. Rowland, Stephanie G. Cremers, Peter D. Weinberg, and Spencer J. Sherwin. "Age-Related Differences in Haemodynamics of the Rabbit Aorta and Comparison With Average Maps of Atherosclerotic Lesion Prevalence." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80310.

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The focal occurrence of atherosclerotic lesions around branching points and in curved vessels has led to the hypothesis that haemodynamics plays an important role in the development of the disease. The spatial distribution of atherosclerosis is also age-dependent in humans and rabbits [1]; detailed maps of disease prevalence in aortas of immature and mature rabbits were presented recently [2]. Vincent et al. [3] applied computational fluid dynamics to study blood flow in the aorta of a mature rabbit, but they did not investigate age-dependent effects. The purpose of the present study was to qu
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Pramuanjaroenkij, Anchasa, Kannika Wongpanit, Gorrawis Phonong, Burin Chaiburi, and Sadık Kakaç. "Relationships Between Hematocrit and Sample Flows on Lab-on-a-Chip." In ASME 2013 4th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/mnhmt2013-22240.

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In this work, the reusable Lab-on-a-Chip or LOC was fabricated and developed to reduce its investment cost and to ease its operations. A sandwiched acrylic set was chosen to assemble the PDMS LOC which was aimed to investigate biological samples, especially the samples from animals. Chicken and sheep blood were chosen as the samples to implement two-phase flows with different red-blood-cell shapes. The chicken blood flow represented the viscous two-phase flow with the oval shape particles while the sheep blood flow represented the inadhesive samples with the round particles. The LOC electrodes
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Nievelstein, P. F. E. M., J. D. Banga, M. Ottenhof-Rovers, J. J. Zwaginga, P. G. de Groot, and J. J. Sixma. "ADHESION OF BLOOD PLATELETS FROM PATIENTS WITH DIABETES MELLITUS TYPE I, TO THE ENDOTHELIAL CELL MATRIX OF HUMAN VASCULAR ENDOTHELIAL CELLS, UNDER FLOW CONDITIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643105.

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Platelet activation in diabetes mellitus may precede vasculopathy. We have studied platelet adhesion and thrombus formation in flowing blood of diabetic patients without macro-and microvascular complications. Platelet function and release, bleeding time, fibrinogen, FVIII:RAg, Ri:Co, Triglycerides, Cholesterol and HDL Cholesterol levels, Apo A, Apo B and TK values were in the normal range. Glucose levels and HBA1 were increased. The matrix of cultured human umbilical vein endothelial cells (ECM) was used for adhesion studies.In an adhesion model with citrated blood (3.1%) and an untreated ECM,
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Fu, Gen, and Alexandrina Untaroiu. "A Computational Modelling for Hemodynamic Conditions Following Flow-Diverting Treatment in Cerebral Aneurysms." In ASME 2018 5th Joint US-European Fluids Engineering Division Summer Meeting. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/fedsm2018-83408.

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Abstract:
Cerebral aneurysms are abnormal dilations of blood vessels within the skull that, in some cases, may rupture and bleed. The rupture of an aneurysm can cause significant bleeding into or around the brain (a stroke). Flow diverters are specially designed low porosity stents that are deployed into the parent artery to cover the neck of the aneurysm. The dense mesh-like structure of flow diverters aims at redirecting flow from the aneurysm to the parent artery and vice versa, resulting in flow stasis in the aneurysm and promoting thrombus formation conditions. The thrombosed aneurysm is then resor
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