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Dissertations / Theses on the topic 'Avidity'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Wernecke, Norman. "Seroprävalenz von Masernvirus-IgG Antikörpern: Untersuchung zum Zusammenhang zwischen Avidität und In-Vitro-Neutralisationsfähigkeit." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-211333.

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Die vorliegende Arbeit hatte das Ziel, die Korrelation zwischen der Avidität der Anti-Masern-IgG-Antikörper und deren In-Vitro-Neutralisationsfähigkeit zu untersuchen, sowie mittels Datenbankanalyse die Seroprävalenz von schützenden Antikörpern gegen Masern und den Impfstatus der Kinder- und Jugendlichen festzustellen. Die lineare Korrelation zwischen Neutralisationsfähigkeit und Avidität war in dieser Stichprobe schwach (ρ=0,240, p=0,006). Für hohe IgG Konzentrationen über 1000 mIU/ml fand sich eine mittlere Korrelation zwischen Avidität und Neutralisationstiter (ρ=0,612; p<0,001). Bei den u

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2

Achilli, Silvia. "Production recombinante de récepteurs lectines de type C et identification de ligands sélectif : de nouveaux outils pour la modulation du système immunitaire." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV014/document.

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Les lectines de type C (CLRs) sont des récepteurs impliqués dans la reconnaissance d’oligosaccharides et principalement exprimés à la surface des cellules présentatrices d’antigène (APCs) et notamment des cellules dendritiques (DCs), véritable sentinelle de notre système immunitaire. Elles sont impliquées dans la reconnaissance de motifs spécifiques exprimés à la surface d’agents pathogènes et sont capables de stimuler le système immunitaire afin de déclencher une réponse adaptée. Ce rôle crucial joué par les CLRs dans l’équilibre de la réponse immunitaire confère aux interactions CLR/glycane

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3

Gagnon, Julien. "Les effets synergiques des cytokines pro-inflammatoires et des cytokines impliquées dans l’homéostasie sur les réponses des lymphocytes T CD8 aux antigènes." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8777.

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Résumé : L’IL-7 et l’IL-15 sont des cytokines impliquées dans l’homéostasie des lymphocytes T CD8 naïfs et mémoires respectivement. Lors d’une réponse immunitaire, certaines cytokines pro-inflammatoires, comme l’IL-6 et l’IL-21, sont produites par les cellules du système immunitaire inné. Nous avons observé que certaines cytokines de ces deux groupes (homéostasie et pro-inflammatoires), peuvent avoir un effet synergique sur la fonction des lymphocytes T CD8. Spécifiquement, l’incubation des lymphocytes T CD8 naïfs avec l’IL-6 ou l’IL-21, en présence d’IL-7 ou d’IL-15 cause une forte proliférat

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4

Canelle, Quentin. "Real Time Surface Plasmon Resonance Biosensors, a Powerful Technology to Assess Polyclonal Antibody Avidity." Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/216754.

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The present research focused on the development of a new methodology to assess the strength of the interaction between vaccine antigens and elicited polyclonal antibodies through SPR biosensors. Quantifying the binding strength of polyclonal antibodies is of first importance to evaluate the quality of the vaccine as well as to increase the scientific knowledge of immune protection mechanisms. To now the development of such tool has been complicated by the non-specific binding caused by high protein abundance in the blood and serum samples but also by the way of interpreting the data resulting

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5

Handl, Heather Lyn. "DEVELOPMENT AND EVALUATION OF REVERSE-ENGINEERED MULTIVALENT LIGANDS FOR CANCER IMAGING AND THERAPY." Diss., The University of Arizona, 2005. http://hdl.handle.net/10150/195974.

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Multimeric ligands have the potential to be developed as targeted imaging agents and therapeutics for the diagnosis and treatment of cancer. Multimeric ligands consist of multiple binding residues tethered together by a linker and are capable of simultaneous binding to multiple receptors. This dissertation details the proof-of-principle experiments that establish that multimeric ligands bind with an increased affinity and cooperativity compared to their monomeric counterparts. We have chosen to evaluate combinations of ligands for the human melanocortin 4 receptor (hMC4R), human delta-opioi

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6

Schoendorf, Diana Elisabeth. "Influence of peptide-MHC/TCR avidity on T-cell selection and activation using transgenic models." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369067.

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7

Griffiths, S. J. "Chronic cytomegalovirus infection drives the accumulation of memory T cells with low functional avidity during ageing." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1322698/.

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Immune senescence is associated with a predisposition to infections, poor vaccination responses and early mortality in older individuals. Furthermore, evidence that chronic cytomegalovirus (CMV) infection is a key driver of immune senescence is becoming increasingly recognised. This thesis aimed to investigate the hypothesis that large CD8+ T cell expansions (TCEs) caused by chronic CMV infection during ageing may be instrumental in this association. Data presented here shows CMV-specific CD8+ TCEs that accumulate during ageing are predominately of the CD45RA+ memory phenotype. However, these

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8

Vadakekolathu, J. "Characterisation of high and low avidity peptide specific CD8+ T cells using immunologic, transcriptomic and proteomic tools." Thesis, Nottingham Trent University, 2013. http://irep.ntu.ac.uk/id/eprint/228/.

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One of the hallmarks of successful immunotherapy is the generation of high avidity cytotoxic T cells which can recognise and respond to very low concentration of antigens. This sensitivity of T cells is usually determined by peptide titration ELISpot assays. Even though these assays are generally useful, they are laborious and sample demanding. The assays become even more difficult if the peptide(s) accountable for the generation of vaccine specific responses are unknown such as whole protein or cell vaccines. Therefore, there is a need to identify markers which can quickly and reliably identi

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9

Ashburn, David. "The relevance of IgA and IgE assays, IgG avidity and western blotting in the diagnosis of Toxoplasma infection." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361776.

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To improve diagnosis of <I>Toxoplasma gondii</I> in difficult patient groups, IgA- and IgE-immunosorbent agglutination assays (ISAGA), IgG avidity and Western blotting were developed and assessed. In the ISAGA, rabbit anti-human IgA or anti-human IgE (for the IgA-ISAGA and IgE-ISAGA respectively) was adsorbed onto microtitre plates; formaldehyde fixed tachyzoites were used to identify specific antibody. Both ISAGAs were specific; only 1/482 (0.2%) and 1/513 (0.19%) false positive results were recorded for the IgA and IgE-ISAGA respectively. Both were produced early in infection and were detect

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10

Chilcoat, Clayton Douglas. "Protein Kinase A Regulates β2 Integrin Avidity Activation and Subsequent Neutrophil Activation via Modulation of Myosin Light Chain Kinase". NCSU, 2005. http://www.lib.ncsu.edu/theses/available/etd-03312005-093042/.

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β2 integrins are adhesion molecules on the surface of neutrophils. Avidity activation of β2 integrins includes transportation of pre-formed integrins to the cell surface and a conformational change in the integrin to a high-binding state. Upon binding ligand, β2 integrins initiate a signaling cascade that results in activation of the neutrophil to a pro-inflammatory state, and the inhibition of this signal can prevent further activation of the neutrophil. cAMP and it effector protein kinase A (PKA) exert a generally inhibitory effect upon neutrophil activation. PKA has been shown to inactivate

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11

Galperin, Moran. "Molecular and functional characterization of high avidity T cell receptors preferentially expressed by HIV-specific CD4 + T cells from HIV controllers." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC251.

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Les « HIV controllers » (HICS) sont de rares patients qui contrôlent spontanément la réplication du VIH en absence de thérapie antirétrovirale. Ces patients sont caractérisés par un taux normal de Cellules T CD4+ et le maintien d'une charge virale indétectable (< 50 copies d'ARN viral / ml de plasma), et montrent un très faible risque de progression vers le sida, de nombreux travaux suggèrent que le contrôle de la réplication virale chez ces patients est dû à une réponse cellulaire antivirale. Particulièrement efficace, notre équipe a montré que ces hics maintiennent des réponses T CD4+ trè

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12

Porkolab, Vanessa. "Développement de ligands multivalents de nature glycomimétiques dirigés contre les récepteurs lectines de type-C." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV013/document.

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Les composantes innée et acquise de l'immunité travaillent ensemble pour assurer une protection efficace de l'organisme. Les cellules dendritiques, cellules sentinelles de l’immunité capturent via des récepteurs de surface les agents pathogènes et les présentent aux lymphocytes T pour stimuler les réponses immunitaires adaptatives spécifiques. Une famille de ces récepteurs, nommée Récepteurs Lectines de type C (CLRs) ont un rôle important dans la reconnaissance de motifs oligosaccharides des pathogènes. Leurs fonctions sont parfois détournées par certains pathogènes à leur avantage et notammen

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13

Nauerth, Magdalena [Verfasser], Dirk [Akademischer Betreuer] Busch, and Jörg [Akademischer Betreuer] Durner. "Development of a novel TCR avidity assay for human CD8+ T cells / Magdalena Nauerth. Gutachter: Jörg Durner ; Dirk Busch. Betreuer: Dirk Busch." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1024567419/34.

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14

Macre, Miriam de Souza. ""Avaliação da quantificação da avidez dos anticorpos maternos na abordagem laboratorial da toxoplasmose congênita"." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-02122004-094234/.

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A toxoplasmose é uma infecção mundial que é transmitida por carne contendo cistos teciduais, água ou legumes crus contaminados com oocistos, contato com felinos, ou transmissão vertical. A toxoplasmose é usualmente assintomática, mas pode causar doença severa no feto quando transmitida durante fase aguda na mãe. O rastreamento da toxoplasmose congênita é normalmente executado durante o pré-natal, pela detecção de anticorpos IgM específico ou pela demonstração de aumento dos títulos de anticorpos IgG para T.gondii. Neste trabalho, 160 mães IgM positivas em rastreamento externo foram avaliadas p

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15

Loschen, Stephan. "Antikörperreifung in der frühen HIV-Infektion und ihre Anwendung in Inzidenztesten." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16164.

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In dieser Arbeit wurden zwei serologische Teste zur Unterscheidung inzidenter und prävalenter Proben etabliert und validiert, welche auf der Reifung des Immunsystems in der frühen HIV-Infektion basieren. Im BED-ELISA werden anhand von anti-HIV-gp41-spezifischen IgG-Antikörperspiegeln die Proben klassifiziert. Die Aviditäts-Methode (AI) unterscheidet die Bindungsfähigkeit der Antikörper an spezifische Antigene. Das Probenpanel wurde in einem weiteren Inzidenztest, dem IDE-V3-ELISA (Kooperation F. Barin), gemessen welcher den Anstieg der Antikörperreaktivität gegen zwei verschiedene immundomina

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16

Mavin, Sally. "The development of an immunoblot IgG avidity assay to identify antigenic markers for the different stages of Borrelia burgdorferi infection in Scottish patients." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=229432.

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17

Isabel, Thais Ferreira. "Toxoplasmose aguda em gestantes de Araraquara-SP : avaliação da aplicabilidade do teste de avidez de IgG anti-toxoplasma /." Araraquara : [s.n.], 2006. http://hdl.handle.net/11449/91392.

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Resumo: A toxoplasmose na maioria dos casos é assintomática, porém pode causar seqüelas graves no feto, quando transmitida durante a fase aguda da infecção pela gestante. Diante disso, é de fundamental importância o acompanhamento sorológico de gestantes, a fim de definir o momento em que houve a aquisição da infecção por T. gondii, possibilitando assim, o tratamento precoce e diminuindo, portanto, o risco de transmissão congênita. No período de Janeiro a Novembro de 2005, avaliou-se a metodologia sorológica do teste de avidez de IgG anti-Toxoplasma gondii na rotina laboratorial entre as gesta

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18

Weißbrich, Bianca Verfasser], Dirk [Akademischer Betreuer] Busch, and Thorsten [Akademischer Betreuer] [Hugel. "T cell receptor binding avidity of antigen-specific CD8+ cytotoxic T cells in chronic infection / Bianca Weißbrich. Betreuer: Dirk Busch. Gutachter: Thorsten Hugel ; Dirk Busch." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1096459078/34.

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19

Cho, Yi-Li [Verfasser], Dirk [Akademischer Betreuer] Busch, Percy A. [Gutachter] Knolle, and Thomas [Gutachter] Korn. "Stochastic differentiation of single CD4+ T cells is modulated by T cell receptor avidity / Yi-Li Cho ; Gutachter: Percy A. Knolle, Thomas Korn ; Betreuer: Dirk Busch." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1139492896/34.

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20

Smolen, Kinga Krystyna. "Neonatal immunization with Listeria monocytogenes induces T cells with an adult-like avidity, sensitivity, and TCR-Vbeta repertoire, and does not adversely impact the response to boosting." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/21269.

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Neonates are highly susceptible to infection and respond suboptimally to most vaccines. However, our previous studies have shown that a protective Th1-type immune response to neonatal Listeria monocytogenes (Lm) immunization can be induced. In this study, we investigated the impact of neonatal Lm immunization and boosting on the key parameters of the T cell response. We found that immunized murine neonates reached maximum antigen-specific CD8⁺ T cell expansion after only a single immunization, while adults required a booster dose to reach their maximal response. Antigen-specific CD4⁺ expansion

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21

Mushens, Rosemary E. "Production, characterization and avidity measurement of novel mouse monoclonal antibodies against erythrocyte glycophorin C and c-myc using synthetic peptides for in vitro and in vivo immunization." Thesis, University of the West of England, Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392807.

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22

Isabel, Thais Ferreira [UNESP]. "Toxoplasmose aguda em gestantes de Araraquara-SP: avaliação da aplicabilidade do teste de avidez de IgG anti-toxoplasma." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/91392.

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Made available in DSpace on 2014-06-11T19:25:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-08-18Bitstream added on 2014-06-13T20:53:02Z : No. of bitstreams: 1 isabel_tf_me_arafcf.pdf: 1862116 bytes, checksum: d792133dba66b88c4e71af8a6e774544 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>A toxoplasmose na maioria dos casos é assintomática, porém pode causar seqüelas graves no feto, quando transmitida durante a fase aguda da infecção pela gestante. Diante disso, é de fundamental importância o acompanhamento sorológico de gestantes, a fim de definir

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23

Bachem, Gunnar. "Investigation of Cooperativity between Statistical Rebinding and the Chelate Effect on DNA Scaffolded Multivalent Binders as a Method for Developing High Avidity Ligands to target the C-type Lectin Langerin." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22787.

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Aufgrund der Fähigkeit von Langerhans Zellen, welche den C-Typ Lektin (CTL) Rezeptor Langerin exprimieren, Antigene zu internalisieren und T-Zellen zu präsentieren, wurde Langerin als attraktives Ziel für neue Immunotherapien erkannt. Langerin kann Pathogene wie z.B. Viren erkennen, die zur Erhöhung der Avidität Kohlenhydratliganden multivalent präsentieren, da die monovalenten Kohlenhydratliganden nur niedrige Affinitäten für Langerin aufweisen. Die natürlichen monovalenten Kohlenhydratliganden besitzen nur niedrige Affinitäten für Langerin. Inspiriert durch die Natur stellt Multivalenz eine

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24

Bachem, Gunnar [Verfasser]. "Investigation of Cooperativity between Statistical Rebinding and the Chelate Effect on DNA Scaffolded Multivalent Binders as a Method for Developing High Avidity Ligands to target the C-type Lectin Langerin / Gunnar Bachem." Berlin : Humboldt-Universität zu Berlin, 2021. http://d-nb.info/1232725986/34.

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Alvarenga, Fernanda Rassi. "Valor do teste de avidez da IgG como marcador de doença aguda ou crônica e de transmissão vertical na toxoplasmose." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tede/3517.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2014-11-03T20:17:54Z No. of bitstreams: 2 Dissertação - Fernanda Rassi Alvarenga - 2009.pdf: 1178426 bytes, checksum: 23c15006d0ef89ee6336d71ed66e974e (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2014-11-03T20:18:53Z (GMT) No. of bitstreams: 2 Dissertação - Fernanda Rassi Alvarenga - 2009.pdf: 1178426 bytes, checksum: 23c15006d0ef89ee6336d71ed66e974e (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b863

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Meireles, Luciana Regina. "Estudo das Fontes de Infecção da Toxoplasmose Humana em Diferentes localidades do Estado de São Paulo." Universidade de São Paulo, 2001. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-24112004-110833/.

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A toxoplasmose é uma protozoose de alta prevalência no Brasil, causada pelo Toxoplasma gondii, sendo transmitida pela ingestão de alimentos contaminados com oocistos, excretados em fezes de felinos, ou cistos, em carnes cruas ou mal cozidas. A doença é usualmente assintomática, mas em fetos ou pacientes com imunodepressão, pode ser devastadora. Neste trabalho, estudamos a prevalência sorológica da infecção em animais de diferentes regiões do estado de São Paulo, tanto de vida livre, cães (200/ABC) como indicadores ambientais, e gatos (100/São Paulo) como hospedeiros definitivos, e em animais d

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27

Newman, Peter Michael Pathology UNSW. "Antibody and Antigen in Heparin-Induced Thrombocytopenia." Awarded by:University of New South Wales. Pathology, 2000. http://handle.unsw.edu.au/1959.4/17485.

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Immune heparin-induced thrombocytopenia (HIT) is a potentially serious complication of heparin therapy and is associated with antibodies directed against a complex of platelet factor 4 (PF4) and heparin. Early diagnosis of HIT is important to reduce morbidity and mortality. I developed an enzyme immunoassay that detects the binding of HIT IgG to PF4-heparin in the fluid phase. This required techniques to purify and biotinylate PF4. The fluid phase assay produces consistently low background and can detect low levels of anti-PF4-heparin. It is suited to testing alternative anticoagulants because

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Rinaldi, Fabiana Mahylowski. "Imunogenicidade de antígenos de vesículas de membrana externa (OMVs) de Neisseria meningitidis B associada a lípide catiônico (DDA-BF)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-08122014-092828/.

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Neisseria meningitidis é um diplococo Gramnegativo, aeróbio e encapsulado, causador mais comum de meningite e septicemia. Este agente é o principal causador de infecções bacterianas invasivas no mundo. Apesar de existirem 13 sorogrupos de N. meningitidis, apenas 6 são capazes de causar infecção: A, B, C, W135, X e Y. O sorogrupo B difere dos outros sorogrupos patogênicos por sua cápsula polissacáride ter composição idêntica ao ácido policiálico, presente em muitas glicoproteínas humanas, particularmente encontrados no tecido cerebral fetal, e bioquimicamente homóloga com a estrutura molecular

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Guéret, Pierre. "Développement clinique de l'EP217609 et de son antidote l'avidine." Thesis, Brest, 2017. http://www.theses.fr/2017BRES0130.

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Les pentasaccharides sont des inhibiteurs indirects du facteur Xa ayant des profils pharmacocinétiques très prédictibles. En raison de la liaison de forte affinité des pentasaccharides à l'antithrombine, cette pharmacocinétique peut être prédite mais aussi transférée à d'autres molécules qui leur sont liées de manière covalente. L'EP42675 combine dans une seule molécule, une antithrombine directe réversible peptidomimétique (analogue de l'α-NAPAP), et un pentasaccharide inhibiteur indirect du facteur Xa antithrombine dépendant (analogue du fondaparinux). L'EP217609 est le dérivé biotinylé de l

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Kudó, Mônica Eriko. "Níveis e avidez de anticorpos IgG específicos para a porção de 19kDa da região C-terminal da proteína-1 de superfície de merozoítos de P. vivax (MSP1 19) em grupos populacionais expostos à malária." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-18042007-150029/.

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O objetivo deste trabalho foi estudar a resposta imune, quanto ao nível e à avidez dos anticorpos IgG, dirigidos contra o antígeno recombinante derivada da Proteína 1 de Superfície de Merozoíto de Plasmodium vivax (PvMSP119) em indivíduos residentes em diferentes áreas endêmicas do Brasil, empregando o teste ELISA. Para tanto, foram estudadas amostras de indivíduos expostos à malária, infectados ou não e em acompanhamento terapêutico. Na padronização das condições de reação, obteve-se uma sensibilidade de 95,00% em amostras de pacientes com gota espessa positiva para P. vivax e uma especificid

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SCHLERET, ROUSSEAU CHRISTINE. "Avidite des anticorps et application au diagnostic serologique de la toxoplasmose." Strasbourg 1, 1995. http://www.theses.fr/1995STR15030.

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Alemayehu, Amare Eshetu. "Analysis of HCV Coinfections among Newly Diagnosed HIV Cases in Germany." Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22502.

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In Anbetracht der enormen Verbesserung der HCV-Therapie durch die Entwicklung hochwirksamer und direkt wirkender Virostatika (DAA) dient diese Studie der Analyse von HCV-Koinfektionen unter den gemeldeten HIV-Neudiagnosen in Deutschland. Zunächst wurde die Eignung zweier kommerzieller HCV Ag/Ab ELISAs, dem Murex (Abbott) und dem Monolisa (Bio-Rad), zum Nachweis von HCV in getrockneten Serumspots (DSS) verglichen. Der Murex-ELISA zeigte sich sensitiver bei Antigen-positiven Plasma-HCV-Serokonversionsproben während der Monolisa eine höhere Sensitivität bei HCV-Antikörper-positiven DSS-Eluaten. D

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Duprat, Delphine. "Avidité des immunoglobulines G dans le diagnostic de la toxoplasmose : intérêt pour dater la contamination." Montpellier 1, 1997. http://www.theses.fr/1997MON11040.

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34

Durance, Timothy Douglas. "Isolation of avidin and lysozyme from egg albumen." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27297.

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A single column cation exchange method was developed which allowed simultaneous recovery of lysozyme and avidin from undiluted egg white using a unique elution sequence which involved accumulation of avidin on the column through several cycles of egg white application and lysozyme elution. Lysozyme was recovered with higher yields than reported for the isoelectric precipitation methods often used in the industry (86% vs 60 - 80%) and in high purity. Avidin recovery was also as good or better than that of previously reported ion exchange methods (74 - 80% vs 17 -80%). The purity of the avidin f

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Larrivée, Stéphane. "Autorité de la voix narrative : récit et commentaire dans les romans Lust et Avidité d'Elfriede Jelinek." Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/27811/27811.pdf.

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Santana, Silas Silva. "Análise cinética da resposta imune humoral contra a proteína recombinante SAG2A em pacientes com Toxoplasmose aguda." Universidade Federal de Uberlândia, 2011. https://repositorio.ufu.br/handle/123456789/16676.

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Fundação de Amparo a Pesquisa do Estado de Minas Gerais<br>Recombinant proteins from Toxoplasma gondii have been used in several experimental models, as well as for serodiagnosis of human toxoplasmosis, particularly to differentiate acute from chronic phases of the infection. In the present study, we evaluated the kinetics of IgM, IgA, and IgG isotypes, in addition to IgG1 and IgG3 subclasses, by testing sequential serum samples from patients with acute toxoplasmosis. It was carried out immunoassays by using SAG2A recombinant antigen and soluble antigen of Toxoplasma (STAg). The avidity of IgG

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PIGNATTO, M. "NANOASSEMBLATI DI AVIDINA E DNA COME STRUMENTI IN MEDICINA E DIAGNOSTICA." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3426589.

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This work originates from the recent discovery of the existence in nature of a high-affinity interaction between avidin and nucleic acids wich can be guided to give rise to discrete and solution stable polyavidin nanoassemblies. The interest towards these systems is due to the fact that, since the latter are composed by many avidin units stably assembled, they can potentially be used in several biotechnological and biomedical applications as an improvement of the classic avidin-biotin system. The work herein described had a two-fold purpose: a) to deepen the knowledge about the molecular ba

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Matheus, Séverine. "Méthodes innovantes pour le diagnostic d'infection par le virus de la dengue." Paris 6, 2008. http://www.theses.fr/2008PA066339.

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Les caractéristiques épidémiologiques de l’infection par le virus de la dengue nécessitaient la mise en place de nouveaux outils diagnostics afin de pouvoir poser un diagnostic différentiel de primo- ou de ré-infection par cet arbovirus, et d’effectuer des investigations de terrain. Les travaux présentés dans cette thèse apportent, par deux approches distinctes, des outils de diagnostic innovants pour une meilleure prise en charge des patients en zone d’endémie. De fait, alors que le test d’avidité des IgG permet de poser un diagnostic différentiel précoce d’infection par une approche immuno-e

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Hennessey, Hooman. "Development of an avidin and C-reactive protein electrochemical immunosensor." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101138.

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It has recently been shown that elevated C-reactive protein (CRP) levels are associated with a blunted systemic endothelial vasodilator function, indicative of a systemic inflammatory response. It has also been recognized that inflammation may contribute to all stages of the atherosclerotic process. Several prospective studies have shown that the level of CRP is a strong predictor of future myocardial dysfunction, stroke, peripheral arterial disease, and vascular death among individuals without known cardiovascular disease. CRP is also found in association with the senile plaques and neurofibr

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Jung, David. "Synthèse de cofacteurs métalliques pour l'élaboration de nouvelles enzymes artificielles : catalyse d'oxydation en solution homogène et construction de systèmes modèles immobilisés à la surface d'électrodes d'or." Paris 7, 2013. http://www.theses.fr/2013PA077186.

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La thèse s'est déroulée dans le contexte d'un projet ANR sur l'élaboration d'enzymes artificielles capables d'activer le dioxygène dans des réactions d'oxydation de molécules organiques. L'idée originale repose sur l'immobilisation de ces biocatalyseurs en liant d'une manière covalente le site catalytique à la surface d'une électrode afin de régénérer le catalyseur via un transfert d'électron direct. La première partie de la thèse traite la formation d'une enzyme artificielle basée sur l'interaction avidine-biotine pour catalyser énantiosélectivement des réactions de sulfoxydation. Selon la st

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Guy, Muriel. "Stratégie de vectorisation d'oligonucléotides antisens par la cobalamine modifiée : évaluation préliminaire sur la lignée cellulaire Caco-2." Nancy 1, 1998. http://www.theses.fr/1998NAN10338.

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Mechain, Bénédicte-Marie. "Intérêt de la mesure d'avidité des IGG dans le diagnostic et le suivi de la toxoplasmose évolutive chez les malades immunodéprimés." Paris 5, 1998. http://www.theses.fr/1998PA05P055.

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Canal, Barcala Ivan. "Funcionalització de superfícies amb lligands per a la seva interacció específica amb avidina i estreptavidina." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/383056.

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Se ha estudiado espectroscópicamente (UV-Vis, Raman, RMN) los equilibrios tautoméricos del ácido 2-(4'-hidroxifenilazo)benzoico (HABA) y el ácido 2-(4'-hidroxi-3',5'- dimetilfenilazo)benzoico. Estos equilibrios están influenciados fuertemente per el estado de protonación (neutro vs. monoaniónico) del compuesto, la polaridad del medio y la substitución en el anillo de hidroxifenilo. En el caso de les especies neutras tanto de HABA como del ácido 2-(4'-hidroxi-3',5'-dimetilfenilazo)benzoico en medios apolares, es predominante el tautómero azo. Aún así, en medios polares, mientras que el tautómer

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Frazzoni, Marcello. "Complessi metallici come “probes” luminescenti per avidina: design e sintesi di leganti bifunzionali piridintriazolo-biotina." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3023/.

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Studi recenti sull’utilizzo di sonde organometalliche per bioconiugazione sfruttano la possibilità di interazione di queste con una proteina, l’avidina, per la sua capacità di coordinarsi selettivamente ad una particolare molecola organica, la biotina. In questa tesi viene descritta la sintesi di due leganti bi-funzionali contenenti sia un’unità capace di fungere da legante per un opportuno metallo, che un’unità di biotina in grado di legarsi all’avidina. La differenza fra i due leganti risiede nello spaziatore che collega le due unità funzionali della molecola. Una volta ottenuti i leganti

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Hinchliffe, Gareth. "Novel biopesticides based on recombinant avidin for protection of crops against insect pests." Thesis, Durham University, 2012. http://etheses.dur.ac.uk/6907/.

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Farmers are required to increase their food productivity to meet the demand from a continually enlarging population. A major constraint on meeting this requirement is the damage created by insect pests. Agricultural pests and associated diseases destroy 30%-40% of the world’s crop produce. The withdrawal of broad-spectrum chemical insecticides, the threat of the development of resistance in insect pests to remaining compounds and the possibility of new pest species spreading into the UK as a result of environmental change have prompted research into alternative pesticides. Protein-based insect

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Mavré, François. "Electrodes enzymatiques bioaffines : modélisation et mise en oeuvre de stratégies d'amplification." Paris 7, 2007. http://www.theses.fr/2007PA077218.

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L'utilisation d'électrodes bioaffines mettant en jeu un principe de reconnaissance biomoléculaire directement à la surface d'une électrode ainsi que sa révélation à l'aide d'un marqueur enzymatique capable de générer un signal électrique est une voie très prometteuse pour la mise en œuvre de dosages performants. Ce travail a pour but de réaliser une étude détaillée des potentialités analytiques offertes par les électrodes enzymatiques bioaffines, en s'appuyant sur la modélisation théorique de leur fonctionnement et une confrontation avec l'expérience. Les paramètres clés qui gouvernent leur se

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González, García Jordi. "Síntesi d’anàlegs de la biotina i lligands divalents. Estudi de la interacció amb avidina i estreptavidina." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399920.

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En el present treball s’han sintetitzat dos lligands divalents i tres lligands monovalents per a les proteïnes avidina i estreptavidina, i s’han determinat les corresponents constants d’associació. Els lligands divalents estan formats per un espaiador semi-rígid que uneix dues entitats monovalents idèntiques amb capacitat per unir-se a aquestes proteïnes. L’entitat monovalent dels extrems consta d’una estructura bicíclica tipus [3.3.1] amb una urea a cada cicle i un grup isopropil al pont més curt, amb una cadena lateral de valerat sobre el carboni cap de pont. L’espaiador està format per u

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Rhönnstad, Sofie. "Biotinylation and high affinity avidin capture as a strategy for LC-MS based metabolomics." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56771.

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<p>Metabolites, small endogenous molecules existing in every living cell, tissue or organism, play a vital role for maintaining life. The collective group of all metabolites, the metabolome, is a consequence of the biochemistry and biochemical pathways that a cell or tissue uses to promote survival. Analysis of the metabolome can be done to reveal changes of specific metabolites which can be a manifestation, a reason or a consequence of for example a disease. The physical chemical diversity amongst these components is tremendous and it poses a large analytical challenge to measure and quantify

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Aubert, Dimitri G. L. "Synthesis of isomers and analogues of biotin to probe their affinity towards (strept)avidin." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405296.

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Pfeifer, Lukas Johannes [Verfasser], Dirk [Akademischer Betreuer] Busch, and Jürgen [Akademischer Betreuer] Ruland. "Analyse des Zusammenhangs zwischen struktureller T-Zell-Avidität und Immunodominanz / Lukas Pfeifer. Gutachter: Jürgen Ruland. Betreuer: Dirk Busch." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1022195816/34.

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