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Journal articles on the topic 'Axoltl'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Wanderer, Emily. "The Axolotl in Global Circuits of Knowledge Production: Producing Multispecies Potentiality." Cultural Anthropology 33, no. 4 (2018): 650–79. http://dx.doi.org/10.14506/ca33.4.09.

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The axolotl is a noteworthy species of salamander, one both biologically remarkable and culturally significant. Native to the canals of Xochimilco, a neighborhood in Mexico City, the charismatic species has deep connections to Mexican history and identity, as well as serving as an important model organism for scientists studying regenerative biology. Drawing on fieldwork in Mexico with restoration ecologists engaged in conserving axolotl habitats, as well as on scientific papers and informal communications among scientists who use axolotls as model organisms, I examine the fate of the axolotl

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Ramos, Alejandra G., Horacio Mena, David Schneider, and Luis Zambrano. "Movement ecology of captive-bred axolotls in restored and artificial wetlands: Conservation insights for amphibian reintroductions and translocations." PLOS ONE 20, no. 4 (2025): e0314257. https://doi.org/10.1371/journal.pone.0314257.

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Amphibians are among the most endangered vertebrates globally due to habitat loss, environmental degradation, and urban expansion. The axolotl (Ambystoma mexicanum), a critically endangered aquatic species endemic to Lake Xochimilco, exemplifies these challenges. This study evaluates the viability of restored and artificial wetlands for axolotl conservation by comparing movement patterns, home range sizes, and habitat use. Using VHF telemetry, we tracked captive-bred axolotls released into both environments. Axolotls survived and foraged successfully in both sites, with those in an artificial

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González-Orozco, Juan Carlos, Itzel Escobedo-Avila, and Iván Velasco. "Transcriptome Profiling after Early Spinal Cord Injury in the Axolotl and Its Comparison with Rodent Animal Models through RNA-Seq Data Analysis." Genes 14, no. 12 (2023): 2189. http://dx.doi.org/10.3390/genes14122189.

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Background: Traumatic spinal cord injury (SCI) is a disabling condition that affects millions of people around the world. Currently, no clinical treatment can restore spinal cord function. Comparison of molecular responses in regenerating to non-regenerating vertebrates can shed light on neural restoration. The axolotl (Ambystoma mexicanum) is an amphibian that regenerates regions of the brain or spinal cord after damage. Methods: In this study, we compared the transcriptomes after SCI at acute (1–2 days after SCI) and sub-acute (6–7 days post-SCI) periods through the analysis of RNA-seq publi

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4

Barr, L. "Hypersensitivity to light of the iris (Sphincter pupillae) of the albino axolotl (Ambystoma mexicanum)." Journal of Experimental Biology 137, no. 1 (1988): 589–96. http://dx.doi.org/10.1242/jeb.137.1.589.

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As is common for amphibians, the sphincter pupillae of the axolotl contracts in vitro in response to illumination with visible light. 1. In a comparison of photomechanical responses of albino and normally pigmented axolotls, similar time courses and maxima of force development were found. 2. The dependence of isometric active force development on the length of the sphincter pupillae is similar to that of other smooth muscles. 3. The action spectrum of the axolotl is similar to the absorption spectrum of frog rhodopsin. 4. At low stimulus strengths, the increase of normalized, isometric, active

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Valerio-Holguín, Fernando. "The Animal Gaze in Julio Cortázar´s “Axolotl”." Theory in Action 15, no. 4 (2022): 103–17. http://dx.doi.org/10.3798/tia.1937-0237.2230.

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In his essay “Why Look at Animals?,” John Berger states that in the first encounter between a human and an animal, the latter's eyes are attentive and wary. The animal looks at the human from the abyss of incomprehension. The human becomes aware of himself by looking back at the animal, who is the radical Other. If the abyss of otherness between humans can be bridged through language, this is impossible between the human and the animal. The gaze is the only possibility for the human to “descend” to the animal. Julio Cortázar wrote “Axolotl,” which tells the story of a man who, fascinated by th

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Figiel, Chester R. "Effects of Water Temperature on Gonads Growth in Ambystoma mexicanum Axolotl Salamanders." Animals 13, no. 5 (2023): 874. http://dx.doi.org/10.3390/ani13050874.

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The thermal environment is a major factor influencing amphibians. For example, amphibian reproduction occurs in specific temperatures, and minor changes in this aspect could have negative impacts on this biological process. Understanding the potential effects of temperature on reproductive output is important from both an ecological and captive breeding colony point of view. I examined temperature effects on reproduction in axolotl reared from egg to adult at 4 temperatures (15 °C, 19 °C, 23 °C, and 27 °C) These adult axolotls (n = 174) were measured and weighed, dissected, and their gonads we

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Frost, S. K., L. G. Epp, and S. J. Robinson. "The pigmentary system of developing axolotls." Development 92, no. 1 (1986): 255–68. http://dx.doi.org/10.1242/dev.92.1.255.

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The albino mutant in the Mexican axolotl (Ambystoma mexicanum) is analysed with respect to the differentiation of pigment cells. Pigment cells were observed with the transmission electron microscope in order to determine any unusual structural characteristics and to determine what happens to each of the cell types as development proceeds. Chemical analyses of pteridine pigments were also carried out, and the pattern of pteridines in albino animals was found to be more complex than, and quantitatively enhanced (at all developmental stages examined) over, the pattern observed in comparable wild-

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8

Tonge, D. A., and P. G. Leclere. "Directed axonal growth towards axolotl limb blastemas in vitro." Neuroscience 100, no. 1 (2000): 201–11. http://dx.doi.org/10.1016/s0306-4522(00)00255-4.

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9

Voss, S. Randal, M. Ryan Woodcock, and Luis Zambrano. "A Tale of Two Axolotls." BioScience 65, no. 12 (2015): 1134–40. http://dx.doi.org/10.1093/biosci/biv153.

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Abstract The Mexican axolotl (Ambystoma mexicanum) is an icon of culture, a revered aquarium pet, and a highly valued animal model in biomedical research. Unfortunately, Mexican axolotls are critically endangered in their natural Xochimilco habitat in Mexico City. If axolotls go extinct, current efforts to conserve the Xochimilico ecosystem will be undermined, as will efforts to genetically manage the laboratory populations that are needed to sustain research efforts around the world. A concerted global effort is needed to protect and manage this irreplaceable species in natural and laboratory

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10

Faisal, Muhammad, Afshan Mehreen, Deli Hays, Faiza Yaseen, and Yujun Liang. "The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations." International Journal of Developmental Biology 68, no. 3 (2024): 103–16. https://doi.org/10.1387/ijdb.240111yl.

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The axolotl, a legendary creature with the potential to regenerate complex body parts, is positioned as a powerful model organism due to its extraordinary regenerative capabilities. Axolotl can undergo successful regeneration of multiple structures, providing us with the opportunity to understand the factors that exhibit altered activity between regenerative and non-regenerative animals. This comprehensive review will explore the mysteries of axolotl regeneration, from the initial cellular triggers to the intricate signaling cascades that guide this complex process. We will delve deeply into t

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Anaya-Lavalle, Brayan Alfonso, and Siever Morales-Cauti. "Valores hematológicos y bioquímicos del axolotl (Ambystoma mexicanum) mantenidos en cautiverio en Lima, Perú." Revista de Investigaciones Veterinarias del Perú 32, no. 6 (2021): e19989. http://dx.doi.org/10.15381/rivep.v32i6.19989.

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El axolotl o ajolote es un anfibio caudado utilizado en numerosos estudios biomédicos por su capacidad regenerativa. Actualmente se encuentra en la categoría de peligro crítico de extinción a consecuencia de la contaminación acuática, caza indiscriminada e introducción de especies invasoras en su medioambiente natural. El objetivo del presente estudio fue determinar los rangos de parámetros hematológicos y bioquímicos de axolotls cautivos en Lima, Perú, para que puedan ser utilizados como referencia durante la evaluación clínica en laboratorios biomédicos y consultorios veterinarios de especie

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Leyte-Manrique, Adrian. "El ajolote del Altiplano en Sierra Gorda-Guanajuato: un acercamiento a su historia natural." Herpetología Mexicana, no. 4 (December 30, 2022): 47–50. http://dx.doi.org/10.69905/4xn7wv32.

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Axolotls are part of the amphibian group, and their ecological and cultural value are undeniable, which is why they are the subject of research by scientists. Being one of the 30 known species of axolotls, Ambystoma velasci, better known as the Altiplano axolotl, is one of the species found in Mexico, and about which little is known about its wildlife. This work presents data about the natural history of A. velasci in the Sierra Gorda Guanajuato Biosphere Reserve, Mexico. It shows how susceptible the species is to changes in its environment, which are caused by human activities, thus making it

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James, Lucas M., Zachary Strickland, Noah Lopez, Jessica L. Whited, Malcolm Maden, and Jada Lewis. "Identification and Analysis of Axolotl Homologs for Proteins Implicated in Human Neurodegenerative Proteinopathies." Genes 15, no. 3 (2024): 310. http://dx.doi.org/10.3390/genes15030310.

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Neurodegenerative proteinopathies such as Alzheimer’s Disease are characterized by abnormal protein aggregation and neurodegeneration. Neuroresilience or regenerative strategies to prevent neurodegeneration, preserve function, or restore lost neurons may have the potential to combat human proteinopathies; however, the adult human brain possesses a limited capacity to replace lost neurons. In contrast, axolotls (Ambystoma mexicanum) show robust brain regeneration. To determine whether axolotls may help identify potential neuroresilience or regenerative strategies in humans, we first interrogate

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Wilson, S., and N. Holder. "Evidence for axonal ‘decision regions’ in the axolotl peripheral nervous system." Development 102, no. 4 (1988): 823–36. http://dx.doi.org/10.1242/dev.102.4.823.

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Horseradish peroxidase (HRP) was employed to analyse the spatial organization of axons within nerves of the axolotl peripheral nervous system. HRP applications to the lateral motor column, spinal nerves and muscle nerve branches were examined after orthograde or retrograde transport. Axons change relative positions at particular limb regions, notably at the limb plexi, but also at branch points at other limb levels. Such areas of axon reorganization (termed ‘decision regions’ in line with Tosney & Landmesser (1985) J. Neurosci. 5, 2345) are interspersed by lengths of nerve in which axons r

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Gutiérrez Angulo, Carlos. "Carbón y cenizas." La Palabra y el Hombre, revista de la Universidad Veracruzana, no. 51 (November 11, 2020): 49–62. http://dx.doi.org/10.25009/lpyh.v0i51.3105.

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El presente dossier es una muestra de la obra gráfica de Carlos Gutiérrez Angulo. Los títulos de algunas de las obras incluidas son: El Axolotito y ella, La Axolota y el Axolote, Tierra de volcanes, Un pez y otros no, El perfume es violáceo, entre otras.

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Bachvarova, Rosemary F., Thomas Masi, Matthew Drum, et al. "Gene expression in the axolotl germ line:Axdazl,Axvh,Axoct-4, andAxkit." Developmental Dynamics 231, no. 4 (2004): 871–80. http://dx.doi.org/10.1002/dvdy.20195.

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Lopez, David, Li Lin, Malcolm Maden, and Edward W. Scott. "Defining the Axolotl Hematopoietic Stem Cell." Blood 118, no. 21 (2011): 1295. http://dx.doi.org/10.1182/blood.v118.21.1295.1295.

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Abstract Abstract 1295 Hematopoietic stem cells (HSCs) are the most therapeutically usable stem cells to date. HSC derived cells are involved in wound healing responses throughout the body. The goal of our study is to discovery methods to promote improved regenerative responses from mammalian HSC. The champion of vertebrate regeneration is the axolotl. It can regrow entire limbs, major portions of most internal organs – including the brain and spinal cord. Recent advances in the production of transgenic axolotl, complete mapping of the axolotl transcriptome and production of gene expression ar

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Zammit, P. S., J. D. W. Clarke, J. P. Golding, I. A. Goodbrand, and D. A. Tonge. "Macrophage response during axonal regeneration in the axolotl central and peripheral nervous system." Neuroscience 54, no. 3 (1993): 781–89. http://dx.doi.org/10.1016/0306-4522(93)90247-d.

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Johnson, Andrew D., Brian Crother, Mary E. White, et al. "Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineage." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 358, no. 1436 (2003): 1371–79. http://dx.doi.org/10.1098/rstb.2003.1331.

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How germ cells are specified in the embryos of animals has been a mystery for decades. Unlike most developmental processes, which are highly conserved, embryos specify germ cells in very different ways. Curiously, in mouse embryos germ cells are specified by extracellular signals; they are not autonomously specified by maternal germ cell determinants (germ plasm), as are the germ cells in most animal model systems. We have developed the axolotl ( Ambystoma mexicanum ), a salamander, as an experimental system, because classic experiments have shown that the germ cells in this species are induce

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Roy, Stéphane, and Mathieu Lévesque. "Limb Regeneration in Axolotl: Is It Superhealing?" Scientific World JOURNAL 6 (2006): 12–25. http://dx.doi.org/10.1100/tsw.2006.324.

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The ability of axolotls to regenerate their limbs is almost legendary. In fact, urodeles such as the axolotl are the only vertebrates that can regenerate multiple structures like their limbs, jaws, tail, spinal cord, and skin (the list goes on) throughout their lives. It is therefore surprising to realize, although we have known of their regenerative potential for over 200 years, how little we understand the mechanisms behind this achievement of adult tissue morphogenesis. Many observations can be drawn between regeneration and other disciplines such as development and wound healing. In this r

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Scadding, Steven R. "Vitamin A modification of the positional information of blastema cells during limb regeneration in the axolotl Ambystoma mexicanum." Canadian Journal of Zoology 66, no. 9 (1988): 2065–70. http://dx.doi.org/10.1139/z88-304.

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Vitamin A is known to cause proximodistal duplication of parts of the limb during limb regeneration in amphibians. The objective of this study was to investigate the nature and location of the cellular changes induced by vitamin A when it causes this duplication in the axolotl Ambystoma mexicanum. When axolotls were treated with retinol palmitate by immersion for 14 days before limb amputation, proximodistal duplications were still observed in subsequent regenerates of limbs amputated after vitamin A treatment was discontinued. This observation suggests that some characteristic of the cells is

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Kropf, Nina, Kartik Krishnan, Moses Chao, Mark Schweitzer, Zehava Rosenberg, and Stephen M. Russell. "Sciatic nerve injury model in the axolotl: functional, electrophysiological, and radiographic outcomes." Journal of Neurosurgery 112, no. 4 (2010): 880–89. http://dx.doi.org/10.3171/2008.10.jns08222.

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Object The 2 aims of this study were as follows: 1) to establish outcome measures of nerve regeneration in an axolotl model of peripheral nerve injury; and 2) to define the timing and completeness of reinnervation in the axolotl following different types of sciatic nerve injury. Methods The sciatic nerves in 36 axolotls were exposed bilaterally in 3 groups containing 12 animals each: Group 1, left side sham, right side crush; Group 2, left side sham, right side nerve resected and proximal stump buried; and Group 3 left side cut and sutured, right side cut and sutured with tibial and peroneal d

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Clemen, Günter, Uwe Kierdorf, Michael Hermes, and Horst Kierdorf. "The Source of Melanocytes in Ortho- and Heterotopic Tail Regenerates of Axolotls and the Dependence of the Regenerative Response on the Presence of Neural Tissue." Anatomia 3, no. 1 (2024): 29–49. http://dx.doi.org/10.3390/anatomia3010004.

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We studied the regeneration of orthotopic and heterotopic tails in larval axolotls. First, we analyzed tail regeneration following reciprocal exchange of cuffs of tail integument between dark-colored (wild-type) and yellow-colored (hybrid) larval animals. Second, we studied tail regeneration in larval axolotls following transplantation of cuffs of tail integument from metamorphosed dark-colored conspecifics and from an adult fire salamander. In all cases, the amputation planes involved the transplanted integumental cuffs. In the first experiment, the regenerated tails showed the color of the h

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Frost, S. K., L. G. Epp, and S. J. Robinson. "The pigmentary system of developing axolotls." Development 95, no. 1 (1986): 117–30. http://dx.doi.org/10.1242/dev.95.1.117.

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The axanthic mutant in the Mexican axolotl (Ambystoma mexicanum) was analysed with respect to the differentiation of pigment cells. Transmission electron micrographs revealed the presence of melanophores and cells that are described as unpigmented xanthophores in axanthic skin. Iridophores apparently failed to differentiate in axanthic axolotls (a pattern similar to that observed in melanoid axolotls). Chromatographic analyses of skin extracts confirmed that there are no pteridines (xanthophore pigments) in axanthic skin, suggesting that the axanthic gene may affect pteridine biosynthesis at s

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Leyte-Manrique, Adrian, and Francisco Alejo-Iturvide. "Crónica de una extinción anunciada: el caso del ajolote Abystoma velasci en Sierra Gorda de Guanajuato." Herpetología Mexicana, no. 7 (June 30, 2024): 23–30. http://dx.doi.org/10.69905/3myjg125.

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Amphibians are organisms that are very sensitive to changes in their environment, which has an impact on their survival, such is the case of emblematic animals such as ambistomatids, a family of amphibians whose larval forms are commonly known as axolotls, of which 18 species are known in Mexico and where one of them is the Bajío axolotl Ambystoma velasci. In this paper I make a chronicle and a reflection on the natural history of a population immersed in Charco Azul, Xichú, Guanajuato, within the Sierra Gorda-Guanajuato Biosphere Reserve, where I mention the real problems of the species to be

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Chami, Batoul, Bella Bates, Luke Shaheen, and John Abramyan. "Characterization of the developing axolotl nasal cavity supports multiple evolution of the vertebrate choana." International Journal of Developmental Biology 67, no. 2 (2023): 57–63. http://dx.doi.org/10.1387/ijdb.230098ja.

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All tetrapods (mammals, birds, reptiles, and amphibians) share the ability to breathe with their mouths closed due to the formation of choanae, which are openings that allow communication between the nasal and oral cavities. In most fishes, the nasal cavities serve a strictly olfactory function, possessing incurrent and excurrent nares that lie outside of the mouth and therefore, never communicate with the respiratory system. It is not until the evolution of tetrapods, in which the nasal cavities consistently open into the mouth, that they are used both for olfaction and for respiration. Howev

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Wight, Doris T. "Cortázar's Axolotl." Explicator 45, no. 2 (1987): 59–63. http://dx.doi.org/10.1080/00144940.1987.9938658.

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Sandoval-Guzmán, Tatiana. "The axolotl." Nature Methods 20, no. 8 (2023): 1117–19. http://dx.doi.org/10.1038/s41592-023-01961-5.

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Wilson, S., D. A. Tonge, and N. Holder. "Homing behaviour of regenerating axons in the amphibian limb." Development 106, no. 4 (1989): 707–15. http://dx.doi.org/10.1242/dev.106.4.707.

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Following peripheral nerve deviation in the limbs of urodele amphibians axons regrow distally toward their previous target muscles (Holder et al. 1984; Proc. Roy. Soc. Lond. B 222, 477–489). This study describes analysis of this axon regeneration over time following deviation of the forearm flexor nerve in Triturus cristatus and the extensor cranialis nerve in the axolotl. Using horseradish peroxidase (HRP) axonal tracing, electrophysiology and electron microscopy, we describe the sequence of events leading to reestablishment of functional innervation. HRP fills reveal axons leaving the deviat

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Tomlinson, B. L., and R. A. Tassava. "Dorsal root ganglia grafts stimulate regeneration of denervated urodele forelimbs: timing of graft implantation with respect to denervation." Development 99, no. 2 (1987): 173–86. http://dx.doi.org/10.1242/dev.99.2.173.

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Amphibian forelimb regeneration is a nerve-dependent process; nerves presumably release one or more neurotrophic factors that stimulate blastema cell division. To date several candidate molecules/factors have been shown to stimulate macromolecular synthesis and/or mitosis but sustained cell cycle activity and blastema development have not been achieved. Because dorsal root ganglia (DRG) implants are capable of promoting regeneration of denervated adult newt limbs (Kamrin & Singer, 1959), we have evaluated the DRG stimulation of regeneration in denervated limbs of adult newts and larval axo

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Scaps, Patrick, François Bernet, Jean Gautron, and Bénoni Boilly. "Activities of acetylcholinesterase, choline acetyltransferase, and catecholamine production in the spinal cord of the axolotl Ambystoma mexicanum during forelimb regeneration." Biochemistry and Cell Biology 72, no. 5-6 (1994): 188–94. http://dx.doi.org/10.1139/o94-028.

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Amputation of an axolotl limb causes severance of the brachial nerves, followed by their regeneration into a blastema. It is known that these nerves provide a neurotophic factor to blastemal cells. To approach the problem of the response of spinal cord nerve centers to forelimb amputation, we have studied biosynthetic activities in the nerve centers involved in axonal injury during limb regeneration. We report that the acetylcholinesterase (AChE) activity in the spinal cord is elevated 2 days (+ 69%) and 7 days (+ 28%) after limb amputation compared with levels in unamputated control animals,

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Kabangu, Mirindi, Raissa Cecil, Lloyd Strohl, Nataliya Timoshevskaya, Jeramiah J. Smith, and Stephen R. Voss. "Leukocyte Tyrosine Kinase (Ltk) Is the Mendelian Determinant of the Axolotl Melanoid Color Variant." Genes 14, no. 4 (2023): 904. http://dx.doi.org/10.3390/genes14040904.

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The great diversity of color patterns observed among amphibians is largely explained by the differentiation of relatively few pigment cell types during development. Mexican axolotls present a variety of color phenotypes that span the continuum from leucistic to highly melanistic. The melanoid axolotl is a Mendelian variant characterized by large numbers of melanophores, proportionally fewer xanthophores, and no iridophores. Early studies of melanoid were influential in developing the single-origin hypothesis of pigment cell development, wherein it has been proposed that all three pigment cell

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Nowoshilow, Sergej, Siegfried Schloissnig, Ji-Feng Fei, et al. "The axolotl genome and the evolution of key tissue formation regulators." Nature 554, no. 7690 (2018): 50–55. http://dx.doi.org/10.1038/nature25458.

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Abstract Salamanders serve as important tetrapod models for developmental, regeneration and evolutionary studies. An extensive molecular toolkit makes the Mexican axolotl (Ambystoma mexicanum) a key representative salamander for molecular investigations. Here we report the sequencing and assembly of the 32-gigabase-pair axolotl genome using an approach that combined long-read sequencing, optical mapping and development of a new genome assembler (MARVEL). We observed a size expansion of introns and intergenic regions, largely attributable to multiplication of long terminal repeat retroelements.

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Afnan, Naufal Izzudin, Abd Rahem Faqih, and Muhammad Dailami. "THE EFFECT OF TEMPERATURE MANIPULATION ON THE GROWTH OF AXOLOTL (Ambystoma mexicanum)." Jurnal Perikanan Unram 15, no. 2 (2025): 849–58. https://doi.org/10.29303/jp.v15i2.1463.

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Axolotl (Ambystoma mexicanum) merupakan hewan unik yang populasinya sudah terancam punah. Axolotl merupakan yang unik, salah satu keunikannya adalah dapat meregenerasi hampir seluruh bagian tubuhnya. Di Indonesia sendiri masih sedikit sekali yang membudidayakan hewan satu ini. Di Indonesia kegiatan budidaya axolotl banyak menemui hambatan terutama karena faktor lingkungan yang sangat berbeda dengan habitat aslinya. Salah satu kendala utama untuk membudidayakan axolotl adalah suhu. Untuk membuat lingkungan yang sesuai untuk axolotl tumbuh dan berkembang diperlukan bantuan alat. Salah satu alat

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Stephens, N., and N. Holder. "The pattern of innervation in serially duplicated axolotl limbs: further evidence for the existence of local pathway cues?" Development 100, no. 3 (1987): 479–87. http://dx.doi.org/10.1242/dev.100.3.479.

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The innervation of the biceps muscle was examined in regenerated and vitamin A-induced serially duplicated axolotl forelimbs using retrograde transport of horseradish peroxidase. The regenerated biceps muscle becomes innervated by motor neurones in the same position in the spinal cord as the normal biceps motor pool. In previous experiments in which the innervation of a second copy of a proximal limb muscle was examined in serially duplicated limbs (Stephens, Holder & Maden, 1985), the duplicate muscle was found to become innervated by motor neurones that would normally have innervated dis

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Scadding, Steven R. "Actinomycin D, cycloheximide, and tunicamycin inhibit vitamin A induced proximodistal duplication during limb regeneration in the axolotl Ambystoma mexicanum." Canadian Journal of Zoology 66, no. 4 (1988): 879–84. http://dx.doi.org/10.1139/z88-130.

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Vitamin A is known to cause proximodistal duplication of parts of the limb during limb regeneration in amphibians. The objective of this study was to investigate the cellular site of action of vitamin A when it causes this duplication in the axolotl Ambystoma mexicanum. Both forelimbs of larval axolotls were amputated through the radius–ulna, and treated with retinol palmitate by immersion for 10 days. Actinomycin D, cycloheximide, and tunicamycin were each applied to the right forelimb by implantation of a silastin block containing one of these antibiotics on days 2 and 6 postamputation. The

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Takada, Makoto, Hideko Yai, and Shinji Komazaki. "Effect of calcium on development of amiloride-blockable Na+ transport in axolotl in vitro." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 275, no. 1 (1998): R69—R75. http://dx.doi.org/10.1152/ajpregu.1998.275.1.r69.

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The axolotl, Ambystoma mexicanum, which has no specific calcium-containing sieve layer in the dermis, provides useful material for the study of the effect of Ca2+ on the development of amiloride-blockable active Na+ transport across the skin of amphibians. We raised axolotls in thyroid hormone or aldosterone or cultured the skin with corticoid plus one of several Ca2+ concentrations and found that 1) although the short-circuit current (SCC) was increased by both aldosterone and 3,3′,5-triiodo-l-thyronine in vivo, only corticoid was necessary for such an increase in vitro; 2) the development of

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38

Neff, Ellen P. "Updates for axolotl." Lab Animal 50, no. 6 (2021): 149. http://dx.doi.org/10.1038/s41684-021-00788-x.

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39

Armstrong, John B. "The axolotl mutants." Developmental Genetics 6, no. 1 (1985): 1–25. http://dx.doi.org/10.1002/dvg.1020060102.

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40

Reiß, Christian, Uwe Hoßfeld, and Lennart Olsson. "150 Jahre Axolotl." Biologie in unserer Zeit 44, no. 3 (2014): 188–95. http://dx.doi.org/10.1002/biuz.201410538.

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41

Lopez, David, Li Lin, James R. Monaghan, et al. "Mapping hematopoiesis in a fully regenerative vertebrate: the axolotl." Blood 124, no. 8 (2014): 1232–41. http://dx.doi.org/10.1182/blood-2013-09-526970.

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42

Fei, Ji-Feng, Maritta Schuez, Dunja Knapp, Yuka Taniguchi, David N. Drechsel, and Elly M. Tanaka. "Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration." Proceedings of the National Academy of Sciences 114, no. 47 (2017): 12501–6. http://dx.doi.org/10.1073/pnas.1706855114.

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Salamanders exhibit extensive regenerative capacities and serve as a unique model in regeneration research. However, due to the lack of targeted gene knockin approaches, it has been difficult to label and manipulate some of the cell populations that are crucial for understanding the mechanisms underlying regeneration. Here we have established highly efficient gene knockin approaches in the axolotl (Ambystoma mexicanum) based on the CRISPR/Cas9 technology. Using a homology-independent method, we successfully inserted both the Cherry reporter gene and a larger membrane-tagged Cherry-ERT2-Cre-ERT

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43

Cuny, Robert, and George M. Malacinski. "Banding differences between tiger salamander and axolotl chromosomes." Canadian Journal of Genetics and Cytology 27, no. 5 (1985): 510–14. http://dx.doi.org/10.1139/g85-076.

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The Hoechst 33258 – Giemsa banding patterns were compared on axolotl (Ambystoma mexicanum Shaw) and axolotl – tiger salamander (Ambystoma tigrinum Green) species hybrid prophase chromosomes. Approximately 369 bands per haploid chromosome set were seen in the axolotl and about 344 bands in the tiger salamander. In the haploid set of 14 chromosomes, chromosome 3 has a constant short or q-arm terminal constriction at the location of the nucleolar organizer. Chromosomes 14 Z and W carry the sex determinants, the female being the heterogametic sex (ZW). The banding patterns of chromosomes 1, 6, 11,

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Narayanan, Swarnarekha, Sai Sriram S., and Balasubramanian D. "Diffuse Axonal Injury: An institute Experience." International Journal of Neurology and Neurosurgery 11, no. 2 (2019): 137–40. http://dx.doi.org/10.21088/ijnns.0975.0223.11219.5.

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Iskandarovich, Iskandarov Alisher, Yakubov Khayot Hamidullaevich, and Ismatov Abrorkhon Askarovich. "FORENSIC EVALUATION OF DIFFUSE AXONAL INJURY." American Journal of Medical Sciences and Pharmaceutical Research 04, no. 04 (2022): 16–18. http://dx.doi.org/10.37547/tajmspr/volume04issue04-04.

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Traumatic brain injury is a sudden damage to the bones of the skull and brain by various mechanical agents. Diffuse axonal injury is a type of traumatic brain injury resulting from a closed brain injury. Traumatic brain injury is the leading cause of death and disability worldwide.

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Whiteley, Mary, and John B. Armstrong. "Ectopic expression of a genomic fragment containing a homeobox causes neural defects in the axolotl." Biochemistry and Cell Biology 69, no. 5-6 (1991): 366–74. http://dx.doi.org/10.1139/o91-056.

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An axolotl (Ambystoma mexicanum) genomic fragment containing the Ahoxl homeobox was placed under the control of the mouse hsp68 promoter, which seems to function constitutively in the axolotl. The resulting construct was injected into fertilized axolotl eggs to see if it would perturb development. Of the injected embryos, 20% showed severe reduction of the anterior neural plate. Later in development, these embryos had small heads, no eyes, and appeared to lack the normal regionalization of the brain. An additional 35% of the embryos were less severely affected, but had reduced or missing eyes.

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Zullian, Chiara, Aurore Dodelet-Devillers, Stéphane Roy, Pierre Hélie, and Pascal Vachon. "Abdominal Distension Associated with Luminal Fungi in the Intestines of Axolotl Larvae." Case Reports in Veterinary Medicine 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/851689.

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Axolotls show a remarkable regeneration capacity compared with higher vertebrates, regenerating missing appendages such as limbs and tail as well as other body parts (i.e., apex of the heart, forebrain, and jaw) after amputations which makes this animal a very interesting research model for tissue regeneration mechanisms. Larvae are individually housed in a 20% Holtfreter’s solution within clear plastic containers. The photoperiod light : darkness cycle is 12 : 12 h. Larvae with a total body length of less than 5 cm are fed once a day with large brine shrimp and blood worm. Albino larvae appea

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Firmat, Gustavo Pérez. "Lectura de/en "Axolotl"." Chasqui 17, no. 2 (1988): 41. http://dx.doi.org/10.2307/29740084.

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Purnell, Beverly A. "Regrow like an axolotl." Science 355, no. 6325 (2017): 592.1–592. http://dx.doi.org/10.1126/science.355.6325.592-a.

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Schmitt, Michael. "Buchrezension zu: Der Axolotl." BIOspektrum 26, no. 3 (2020): 346. http://dx.doi.org/10.1007/s12268-020-1387-1.

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