To see the other types of publications on this topic, follow the link: Ayahuasca.
Journal articles on the topic 'Ayahuasca'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Ayahuasca.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Malcolm, Benjamin J., and Kelly C. Lee. "Ayahuasca: An ancient sacrament for treatment of contemporary psychiatric illness?" Mental Health Clinician 7, no. 1 (January 1, 2017): 39–45. http://dx.doi.org/10.9740/mhc.2017.01.039.
Full textAbstract:
Abstract Ayahuasca is a traditional psychoactive sacrament that's been used in Amazonian shamanic rituals for hundreds of years. Ayahuasca is notorious for its psychedelic properties produced from the combination of monoamine oxidase inhibitors (MAOIs) found in the Banisteriopsis caapi vine and N-N-dimethyltryptamine from Psychotria viridis or Diplopterys cabrerana. Recently, ritual use of ayahuasca has increased and garnered attention for its potential in treating mental illnesses, such as substance use and depressive disorders. Due to its MAOI properties, there are serious drug interactions that may be of concern among patients who participate in ayahuasca use. The objectives of this paper are to describe ayahuasca's pharmacology, potential drug interactions, and clinical data for its treatment potential in psychiatric illness.
2
Horák, Miroslav, Romana Lukášová, and Šárka Vosáhlová. "Glokalizace ayahuasky v ČR a možnosti jejího terapeutického využití v místních podmínkách." Anthropologia integra 6, no. 2 (December 15, 2015): 7–13. http://dx.doi.org/10.5817/ai2015-2-7.
Full textAbstract:
Z ayahuasky, klíčového prvku tradiční domorodé medicíny peruánské Amazonie, se stal globální fenomén. Sezení, během něhož je užívána tato psychoaktivní látka, lze v současné době absolvovat nejen v prostředí jihoamerického deštného pralesa, ale také v České republice. Vzhledem k tomu, že je v ČR ayahuasca pro svůj obsah N, N-dimethyltriptaminu dle nařízení vlády č. 463/2013 Sb., O seznamech návykových látek, nelegální, je tato substance užívána v rámci subkultury. S cílem poprvé zmapovat tento aktuální fenomén jsme provedli pilotní on-line anonymní dotazníkové šetření, ve kterém jsme se mimo jiné zaměřili i na možnosti terapeutického využití této psychoaktivní látky v místních podmínkách. Analýza dat získaných od 70 respondentů ukázala, že ayahuasca je užívána ve všech krajích ČR (nejvíce v Praze) a to zejména z léčebných důvodů. Došlo tak k přizpůsobení tradičního užívání ayahuasky lokálním podmínkám a se vzrůstající informovaností lze předpokládat další rozšíření tohoto sociokulturního jevu. Při dodržení tradičních bezpečnostních zásad má ayahuasca terapeutický potenciál vhodný pro léčbu drogové závislosti a jiných civilizačních chorob.
3
Labate, Beatriz Caiuby. "Encruzilhadas da imprensa:." Revista de Antropologia da UFSCar 1, no. 2 (December 1, 2009): 105–15. http://dx.doi.org/10.52426/rau.v1i2.15.
Full textAbstract:
Recentemente, a Revista Isto É publicou uma reportagem de capa sobre o uso da ayahuasca1 no país, intitulada “As Encruzilhadas do Daime.” 2 O texto noticia que o uso da ayahuasca teria sido “liberado pelo governo federal,” denotando complacência com um “quadro de desorganização e alto risco,” um alarmante “tráfico de ayahuasca” e uma “série de mortes” associadas ao consumo do perigoso “chá alucinógeno.” A notícia principal à qual se refere a reportagem é a recente publicação no Diário Oficial da União da Resolução no 1 do Conselho Nacional de Políticas sobre Drogas (CONAD), de 25 de janeiro de 2010.3 Esta resolução consistiu na publicação do Relatório Final do 4Grupo Multidisciplinar de Trabalho sobre a Ayahuasca (GMT), concluído em 2006. O GMT reuniu representantes do governo, cientistas de várias áreas e líderes das religiões ayahuasqueiras, e produziu um documento estabelecendo uma deontologia do uso da ayahuasca, isto é, uma série de regras e princípios éticos orientando o consumo da ayahuasca. Realizarei aqui uma análise desta reportagem, e apontarei como ela não investiga o que anuncia investigar. Este texto, é importante notar, não pretende fazer uma reflexão 5mais sistemática sobre como a mídia lida com o tema das drogas. No final, apresento um breve comentário sobre os dilemas do antropólogo diante da imprensa, esperando, assim, estimular reflexões análogas em meus colegas.
4
Bouso, José Carlos, Óscar Andión, Jerome J. Sarris, Milan Scheidegger, Luís Fernando Tófoli, Emérita Sátiro Opaleye, Violeta Schubert, and Daniel Perkins. "Adverse effects of ayahuasca: Results from the Global Ayahuasca Survey." PLOS Global Public Health 2, no. 11 (November 16, 2022): e0000438. http://dx.doi.org/10.1371/journal.pgph.0000438.
Full textAbstract:
Introduction Ayahuasca is a plant-based decoction native to Amazonia, where it has a long history of use in traditional medicine. Contemporary ritual use of ayahuasca has been expanding throughout the world for mental health purposes, and for spiritual and personal growth. Although researchers have been conducting clinical trials and observational studies reporting medical and psychological benefits, most of these do not report ayahuasca’s immediate or medium-term adverse effects, so these are underrepresented in the literature. With the expansion of ayahuasca ceremonies from their traditional contexts to countries around the world, there is an important public health question regarding the risk/benefit balance of its use. Methods We used data from an online Global Ayahuasca Survey (n = 10,836) collected between 2017 and 2019 involving participants from more than 50 countries. Principal component analysis was performed to assess group effects. Logistic regression analysis was performed to test for adverse effects associated with history of ayahuasca use, clinical, context of use and spiritual effect variables. Results Acute physical health adverse effects (primarily vomiting) were reported by 69.9% of the sample, with 2.3% reporting the need for subsequent medical attention. Adverse mental health effects in the weeks or months following consumption were reported by 55.9% of the sample, however, around 88% considered such mental health effects as part of a positive process of growth or integration. Around 12% sought professional support for these effects. Physical adverse effects were related to older age at initial use of ayahuasca, having a physical health condition, higher lifetime and last year ayahuasca use, having a previous substance use disorder diagnosis, and taking ayahuasca in a non-supervised context. Mental health adverse effects were positively associated with anxiety disorders; physical health conditions; and the strength of the acute spiritual experience; and negatively associated with consumption in religious settings. Conclusions While there is a high rate of adverse physical effects and challenging psychological effects from using ayahuasca, they are not generally severe, and most ayahuasca ceremony attendees continue to attend ceremonies, suggesting they perceive the benefits as outweighing any adverse effects. Knowing what variables might predict eventual adverse effects may serve in screening of, or providing additional support for, vulnerable subjects. Improved understanding of the ayahuasca risk/benefit balance can also assist policy makers in decisions regarding potential regulation and public health responses.
5
Hamill, Jonathan, Jaime Hallak, Serdar M. Dursun, and Glen Baker. "Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness." Current Neuropharmacology 17, no. 2 (January 7, 2019): 108–28. http://dx.doi.org/10.2174/1570159x16666180125095902.
Full textAbstract:
Background: Ayahuasca, a traditional Amazonian decoction with psychoactive properties, is made from bark of the Banisteriopsis caapi vine (containing beta-carboline alkaloids) and leaves of the Psychotria viridis bush (supplying the hallucinogen N,N-dimethyltryptamine, DMT). Originally used by indigenous shamans for the purposes of spirit communication, magical experiences, healing, and religious rituals across several South American countries, ayahuasca has been incorporated into folk medicine and spiritual healing, and several Brazilian churches use it routinely to foster a spiritual experience. More recently, it is being used in Europe and North America, not only for religious or healing reasons, but also for recreation. Objective: To review ayahuasca’s behavioral effects, possible adverse effects, proposed mechanisms of action and potential clinical uses in mental illness. Method: We searched Medline, in English, using the terms ayahuasca, dimethyltryptamine, Banisteriopsis caapi, and Psychotria viridis and reviewed the relevant publications. Results: The following aspects of ayahuasca are summarized: Political and legal factors; acute and chronic psychological effects; electrophysiological studies and imaging; physiological effects; safety and adverse effects; pharmacology; potential psychiatric uses. Conclusion: Many years of shamanic wisdom have indicated potential therapeutic uses for ayahuasca, and several present day studies suggest that it may be useful for treating various psychiatric disorders and addictions. The side effect profile appears to be relatively mild, but more detailed studies need to be done. Several prominent researchers believe that government regulations with regard to ayahuasca should be relaxed so that it could be provided more readily to recognized, credible researchers to conduct comprehensive clinical trials.
6
Gilbert, Cody Sykes, Mitch Earleywine, Maha N. Mian, and Brianna R. Altman. "Symptom specificity of ayahuasca's effect on depressive symptoms." Journal of Psychedelic Studies 5, no. 1 (May 11, 2021): 37–43. http://dx.doi.org/10.1556/2054.2021.00165.
Full textAbstract:
AbstractBackgroundAyahuasca's effects on symptoms of depression have generated considerable optimism. Clients frequently report more concern about some symptoms than others, and available treatments alter symptoms differentially. Few studies address the symptom specificity of this psychoactive brew.AimsWe examined self-reported effects of ayahuasca on the individual symptoms of depression assessed by the 10-item short-form of Center for Epidemiological Studies of Depression (CESD-10).MethodsWe asked over 120 participants to complete a retrospective assessment of CESD-10 symptoms one month before and one month after using ayahuasca.ResultsParticipants indicated that ayahuasca had a larger influence on affective symptoms like hope, depressed mood, and happiness, than cognitive, interpersonal, and somatic symptoms like restless sleep, loneliness, and difficulty focusing.ConclusionsPotential clients might appreciate identifying if different treatments provide more relief for some depressive symptoms than others. We examined retrospective reports of ayahuasca's potential for differential impact. Those eager to alter hope, happiness, and other affective symptoms will likely find ayahuasca more helpful than those who want an intervention for restless sleep, loneliness, or trouble focusing. This symptom specificity parallels the effects of serotonergic antidepressant medications, suggesting that psychedelic-assisted psychotherapy using ayahuasca might have considerable appeal for those who seek comparable relief but would rather not use prescription serotonergic medications. Jumpstarting psychotherapy with the rapid onset of ayahuasca-induced relief also appears to have potential.
7
Santos, Guilherme Henrique de Morais, Lucas Silva Rodrigues, Juliana Mendes Rocha, Giordano Novak Rossi, Genís Ona, José Carlos Bouso, Jaime Eduardo Cecilio Hallak, and Rafael Guimarães dos Santos. "Neural Network Modulation of Ayahuasca: A Systematic Review of Human Studies." Psychoactives 2, no. 1 (March 20, 2023): 76–91. http://dx.doi.org/10.3390/psychoactives2010006.
Full textAbstract:
Background: Ayahuasca is a serotoninergic hallucinogen that plays a central role in the Amazonian traditional medicine. Its psychoactive effects are associated with the presence of N,N-dimethyltryptamine (DMT), and monoamine oxidase inhibitors (MAO-A). Advances in neuroimaging investigations have provided insight into ayahuasca’s neurobiological mechanisms of action. Methods: Selecting only studies with neuroimaging results related to human ayahuasca consumption, we included six articles from a previous systematic review of serotoninergic hallucinogen neuroimaging studies up to 2016. Furthermore, we updated the data with a new systematic search from 2016 to 2022. We searched the PubMed, SciELO, and LILACS databases using the search terms “(ayahuasca OR DMT) AND (MRI OR fMRI OR PET OR SPECT OR imaging OR neuroimaging)”. Results: Our updated search provided five new articles for a total of 11 included in this review. The results on the Default Mode Network (DMN) are evident and may indicate a path to short term neuromodulation. Acutely, local neural networks appeared to become expanded, while overall brain connectivity declined. On chronic consumers, anatomical changes were reported, most notably related to cingulate cortex. Conclusion: Ayahuasca seems to change acute brain connectivity similarly to other psychedelics. The results are preliminary and further studies are warranted.
8
Goldin, Deana, and Deborah Salani. "Ayahuasca." Journal of Addictions Nursing 32, no. 2 (April 2021): 167–73. http://dx.doi.org/10.1097/jan.0000000000000405.
Full text
9
Caicedo, Alhena. "Ayahuasca." Ciencias Sociales y Religión/Ciências Sociais e Religião 23 (August 31, 2021): e021009. http://dx.doi.org/10.20396/csr.v23i00.15093.
Full textAbstract:
Bajo la idea de globalización del ayahuasca se caracterizaría espacialmente el fenómeno de expansión del uso del yagé desde Suramérica hacia el resto del mundo. Sin embargo, esa expansión se ha acompañado más recientemente de la configuración de la idea de una comunidad ayahuasquera internacional. Como “comunidad imaginada”, este espacio se produce y se hace socialmente efectivo a través de imágenes, metáforas y prácticas de representación particulares que, considero, requieren ser pensadas. En ese sentido, mi intención en este artículo es explorar algunas características de la producción simbólica que crea y recrea la comunidad ayahuasquera internacional, y ciertos imaginarios poderosos que la conectan con la Amazonia y sus habitantes. Me interesa así mismo, profundizar en la manera en que se referencian los circuitos internacionalizados del ayahuasca, y cómo aparecen lugares emblemáticos que se han convertido en referentes para esta comunidad. A partir de allí intento caracterizar algunos efectos que tiene la globalización del ayahuasca en los países de la cuenca amazónica.
10
de Pablo Márquez, Bernat, and Beatriz Dietl Gómez-Luengo. "Ayahuasca intoxication." Medicina Clínica (English Edition) 149, no. 3 (August 2017): 136–37. http://dx.doi.org/10.1016/j.medcle.2017.06.035.
Full text
11
dos Santos, Rafael G., José Carlos Bouso, and Jaime E. C. Hallak. "Ayahuasca intoxication." Medicina Clínica (English Edition) 149, no. 10 (November 2017): 461–62. http://dx.doi.org/10.1016/j.medcle.2017.10.006.
Full text
12
Miranda Ordilena Ferreira de, Almeida Marcílio de, Sousa Ilza Maria de Oliveira, Ruiz Ana Lúcia Tasca Gois, Costa José Luiz da, Medeiros Raquel da Silva, and Foglio Mary Ann. "Assessment of environmental condition and drying process of the plants on the concentration of alkaloids and cytotoxicity of traditional Ayahuasca Tea." World Journal of Advanced Research and Reviews 10, no. 2 (May 30, 2021): 075–89. http://dx.doi.org/10.30574/wjarr.2021.10.2.0209.
Full textAbstract:
Introduction: Ayahuasca is a traditional psychoactive tea of Amazonian indigenous, used medicinal and spiritual purposes. Wide variation in the concentration of N,N-dimethyltryptamine (DMT), Harmaline (HRL), Harmine (HRM) and Tetrahydroharmine (THH) alkaloids in Ayahuasca has been reported worldwide. Objective: To evaluate the causes of variations in alkaloids concentrations of Ayahuasca prepared with fresh and dehydrated plants from different environments and determine the best drying method to plants according to alkaloids content and cytotoxicity of Ayahuasca tea. Material and methods: The environment interference on the alkaloids of the two species was evaluated in samples of Ayahuasca tea prepared with fresh plants. The most suitable drying process to the two species was evaluated in sample Ayahuasca tea prepared with plants submitted to drying under the sun conditions and five different temperatures in forced circulation oven. The concentration of the alkaloids determined by high performance liquid chromatography with UV-vis detector with diode array detection (HPLC-DAD). The in vitro cytotoxicity of Ayahuasca was evaluated in human keratinocytes cells (HaCaT) by colorimetric assay. Results: Environmental characteristics, preparation process and temperature of plants drying interfered on DMT, HRL, HRM and THH concentrations of Ayahuasca. No effect cytotoxicity was detected with relationship to psychoactive alkaloids in samples of Ayahuasca tea prepared with fresh or dried plants. Conclusion: Concentration of DMT, HRL, HRM and THH alkaloids in Ayahuasca are influenced by plants environmental. The most suitable drying process was obtained in forced circulation oven at 43 and 45°C to P. viridis leaves and B. caapi stems respectively. The Ayahuasca prepared with fresh or dry plants no showed cytotoxicity in human keratinocytes cells.
13
Netzband, Nige, Simon Ruffell, S. Linton, W. F. Tsang, and T. Wolff. "Modulatory effects of ayahuasca on personality structure in a traditional framework." Psychopharmacology 237, no. 10 (July 23, 2020): 3161–71. http://dx.doi.org/10.1007/s00213-020-05601-0.
Full textAbstract:
Abstract Abstract Ayahuasca is a psychoactive plant brew containing dimethyltryptamine (DMT) and monoamine oxidase inhibitors (MAOIs). It originates from the Amazon basin, where it is used primarily for ceremonial purposes. Ayahuasca tourists are now entering certain communities seeking alternative physical or psychological healing, as well as spiritual growth. Rationale Recent evidence has shown that the similar acting psychedelic compound, psilocybin, facilitated long-term increases in trait openness following a single administration. Objectives This paper assesses the impact of ayahuasca on personality in a traditional framework catering for ayahuasca tourists. Method Within a mixed design, we examined the effect of ayahuasca on participants’ personality (measured by the NEO Personality Inventory 3 questionnaire) across time (pre- to post-ayahuasca administration, and 6-month follow-up), relative to a comparison group (who did not ingest ayahuasca). Results The results demonstrated significant increases in agreeableness pre- and post-ayahuasca administration and significant reductions in neuroticism in 24 participants, relative to the comparison group. Both of these changes were sustained at 6-month follow-up, and trait level increases were also observed in openness at this stage. Additionally, greater perceived mystical experience (measured using the Mystical Experience Questionnaire 30) was associated with increased reductions in neuroticism. Conclusions These findings, which indicate a positive mediating effect of ayahuasca on personality, support the growing literature suggesting potential therapeutic avenues for serotonergic psychedelics.
14
Sapoznikow, Avery, Zachary Walsh, Kenneth W. Tupper, Earth Erowid, and Fire Erowid. "The influence of context on ayahuasca experiences: An analysis of experience reports." Journal of Psychedelic Studies 3, no. 3 (September 2019): 288–94. http://dx.doi.org/10.1556/2054.2019.028.
Full textAbstract:
Background and aims Ayahuasca is a psychedelic decoction prepared from two (or more) plants containing monoamine oxidase inhibitors, N, N-dimethyltryptamine, and other chemicals. Ayahuasca has apparently been used for centuries in the Amazon basin of South America, and in recent years has increasingly been used internationally in diverse contexts. This study aims to elucidate differences between cross-cultural ceremonial and psychonautic contexts of ayahuasca use. Methods This study systematically examines subjective differences across contexts for contemporary ayahuasca-drinking practices. User reports of ayahuasca experiences were subjected to textual analysis to compare use in cross-culturalceremonial contexts that attempt to include elements of traditional Amazonian practices, with psychonautic use that does not formally integrate traditional ceremonial aspects. The experience reports were collected from an online database. Results The use of ayahuasca in a cross-cultural ceremonial context is associated with prominence of affective and motivational features, whereas psychonautic use was associated with an emphasis on cognitive processes. Conclusions The beneficial effects of ayahuasca may operate via affective processing and integration and as such, cross-cultural ceremonial use may have advantages relative to psychonautic use. Findings are considered in light of the importance of context on experiences with ayahuasca and other psychedelic substances.
15
Antunes, Henrique Fernandes. "Liberté, égalité, fraternité?" Ciencias Sociales y Religión 25 (December 19, 2023): e023016. http://dx.doi.org/10.20396/csr.v25i00.8672735.
Full textAbstract:
O presente artigo analisa a proibição do uso da ayahuasca na França. Para isso, nos valemos de um amplo acervo documental que abrange a literatura acadêmica, documentos de órgãos governamentais, decisões judiciais, tratados internacionais, relatórios farmacológicos e entrevistas com atores-chave envolvidos no processo. Inicialmente, descrevemos a inserção da ayahuasca na França e a prisão do grupo do Santo Daime. Em seguida, analisamos os primeiros relatórios farmacológicos sobre a ayahuasca no país, os processos legais e a decisão do governo francês de proibir a ayahuasca em 2005. Após esse panorama, consideramos os desdobramentos da decisão para o uso da ayahuasca na França. Por fim, problematizamos o enquadramento legal da ayahuasca como entorpecente e o estigma dos grupos ayahuasqueiros. Pretendemos demonstrar que a posição da França não é aleatória, mas remete a posição do país em relação à questão das seitas e movimentos sectários.
16
Murphy-Beiner, A., and K. Soar. "Ayahuasca’s ‘afterglow’: improved mindfulness and cognitive flexibility in ayahuasca drinkers." Psychopharmacology 237, no. 4 (January 11, 2020): 1161–69. http://dx.doi.org/10.1007/s00213-019-05445-3.
Full text
17
Rossi, Giordano Novak, Lorena T. L. Guerra, Glen B. Baker, Serdar M. Dursun, José Carlos Bouso Saiz, Jaime E. C. Hallak, and Rafael G. dos Santos. "Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant." Biomolecules 12, no. 11 (November 2, 2022): 1618. http://dx.doi.org/10.3390/biom12111618.
Full textAbstract:
Ayahuasca is a psychoactive brew traditionally used in indigenous and religious rituals and ceremonies in South America for its therapeutic, psychedelic, and entheogenic effects. It is usually prepared by lengthy boiling of the leaves of the bush Psychotria viridis and the mashed stalks of the vine Banisteriopsis caapi in water. The former contains the classical psychedelic N,N-dimethyltryptamine (DMT), which is thought to be the main psychoactive alkaloid present in the brew. The latter serves as a source for β-carbolines, known for their monoamine oxidase-inhibiting (MAOI) properties. Recent preliminary research has provided encouraging results investigating ayahuasca’s therapeutic potential, especially regarding its antidepressant effects. On a molecular level, pre-clinical and clinical evidence points to a complex pharmacological profile conveyed by the brew, including modulation of serotoninergic, glutamatergic, dopaminergic, and endocannabinoid systems. Its substances also interact with the vesicular monoamine transporter (VMAT), trace amine-associated receptor 1 (TAAR1), and sigma-1 receptors. Furthermore, ayahuasca’s components also seem to modulate levels of inflammatory and neurotrophic factors beneficially. On a biological level, this translates into neuroprotective and neuroplastic effects. Here we review the current knowledge regarding these molecular interactions and how they relate to the possible antidepressant effects ayahuasca seems to produce.
18
Rodd, Robin. "It’s all you! Australian ayahuasca drinking, spiritual development, and immunitary individualism." Critique of Anthropology 38, no. 3 (May 14, 2018): 325–45. http://dx.doi.org/10.1177/0308275x18775818.
Full textAbstract:
Ayahuasca, a psychoactive plant decoction, has spread from indigenous communities in South America to urban areas in the Americas, Europe, and Australia where it is used in neoshamanic rituals. This paper draws on ethnography of Australian ayahuasca ceremonies to examine the ways that individualism shapes the structure of ayahuasca rituals, the interpretation of visionary experiences, and notions of spiritual development. I show how the metaphors that Australian drinkers involved in this study use to understand their ayahuasca experiences and spiritual development reflect a form of immunitary individualism, which is premised on the negation of difference and relationality. Secular disenchantment and a culture of narcissism may drive people to seek ayahuasca, but transcendence is interpreted in terms of an expansive, non-relational self. In this sense, neoshamanic ayahuasca culture may be an escape from and reproduction of the culture of narcissism associated with the malaise of modernity.
19
González, Débora, María Carvalho, Jordi Cantillo, Marc Aixalá, and Magí Farré. "Potential Use of Ayahuasca in Grief Therapy." OMEGA - Journal of Death and Dying 79, no. 3 (May 30, 2017): 260–85. http://dx.doi.org/10.1177/0030222817710879.
Full textAbstract:
The death of a loved one is ultimately a universal experience. However, conventional interventions employed for people suffering with uncomplicated grief have gathered little empirical support. The present study aimed to explore the potential effects of ayahuasca on grief. We compared 30 people who had taken ayahuasca with 30 people who had attended peer-support groups, measuring level of grief and experiential avoidance. We also examined themes in participant responses to an open-ended question regarding their experiences with ayahuasca. The ayahuasca group presented a lower level of grief in the Present Feelings Scale of Texas Revised Inventory of Grief, showing benefits in some psychological and interpersonal dimensions. Qualitative responses described experiences of emotional release, biographical memories, and experiences of contact with the deceased. Additionally, some benefits were identified regarding the ayahuasca experiences. These results provide preliminary data about the potential of ayahuasca as a therapeutic tool in treatments for grief.
20
Uthaug, M. V., N. L. Mason, S. W. Toennes, J. T. Reckweg, E. B. de Sousa Fernandes Perna, K. P. C. Kuypers, K. van Oorsouw, J. Riba, and J. G. Ramaekers. "A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats." Psychopharmacology 238, no. 7 (March 10, 2021): 1899–910. http://dx.doi.org/10.1007/s00213-021-05817-8.
Full textAbstract:
AbstractAyahuasca is a plant concoction containing N,N-dimethyltryptamine (DMT) and certain β-carboline alkaloids from South America. Previous research in naturalistic settings has suggested that ingestion of ayahuasca can improve mental health and well-being; however, these studies were not placebo controlled and did not control for the possibility of expectation bias. This naturalistic observational study was designed to assess whether mental health changes were produced by ayahuasca or by set and setting. Assessments were made pre- and post-ayahuasca sessions in 30 experienced participants of ayahuasca retreats hosted in the Netherlands, Spain, and Germany. Participants consumed ayahuasca (N = 14) or placebo (N = 16). Analysis revealed a main effect of time on symptoms of depression, anxiety, and stress. Compared to baseline, symptoms reduced in both groups after the ceremony, independent of treatment. There was a main treatment × time interaction on implicit emotional empathy, indicating that ayahuasca increased emotional empathy to negative stimuli. The current findings suggest that improvements in mental health of participants of ayahuasca ceremonies can be driven by non-pharmacological factors that constitute a placebo response but also by pharmacological factors that are related to the use of ayahuasca. These findings stress the importance of placebo-controlled designs in psychedelic research and the need to further explore the contribution of non-pharmacological factors to the psychedelic experience.
21
Shanon, Benny. "Os conteúdos das visões da ayahuasca." Mana 9, no. 2 (October 2003): 109–52. http://dx.doi.org/10.1590/s0104-93132003000200004.
Full textAbstract:
Este artigo examina os conteúdos das alucinações visuais induzidas pela infusão psicotrópica ayahuasca. Ele faz parte de uma investigação fenomenológica mais ampla que busca estudar a ayahuasca de uma perspectiva psicológico-cognitiva. (Até agora, quase todos os estudos da ayahuasca partiram das ciências naturais ou da antropologia.) Análises comparativas quantitativas revelam que certos itens de conteúdo específico são especialmente prevalescentes em visões da ayahuasca e se reencontram em relatos de informantes de diferentes origens socioculturais. Os resultados são discutidos teoricamente à luz de considerações tanto psicológicas como antropológicas.
22
Soeiro, Herta Maria de Açucena do Nascimento. "PRODUÇÃO CIENTÍFICA SOBRE A AYAHUASCA NA WEB OF SCIENCE: UMA ANÁLISE BIBLIOMÉTRICA." Revista Científica FAEMA 14, no. 2 (December 7, 2023): 447–65. http://dx.doi.org/10.31072/rcf.v14i2.1386.
Full textAbstract:
O presente trabalho teve como objetivo realizar uma análise bibliométrica da produção científica sobre a ayahuasca disponível na Web of Science, abrangendo o período de 1966 a 2023. A intenção foi examinar como, ao longo dos anos, a ayahuasca tem sido abordada como objeto de estudos científicos em diversas áreas do conhecimento, identificando as categorias mais recorrentes, as redes de coautoria, os países que mais publicaram pesquisas e analisar os desdobramentos da contínua produção científica sobre a ayahuasca em escala global. Os trabalhos recuperados demonstram o crescente interesse da comunidade científica em estudar as propriedades biomédicas da ayahuasca, abordando também questões antropológicas, como o uso da ayahuasca em contexto religioso. Foi possível observar o protagonismo do Brasil e das universidades públicas federais como referência nas publicações sobre a temática.
23
Corrêa, Janille Santos, Vanessa Almeida Amorin, Denismar Alves Nogueira, Evelise Aline Soares, Flávia da Ré Guerra, Geraldo José Medeiros Fernandes, Wagner Costa Rossi Júnior, and Alessandra Esteves. "Quantificação neuronal no córtex cerebral de camundongos sob o uso do chá de Ayahuasca." Revista Neurociências 22, no. 3 (September 30, 2014): 388–91. http://dx.doi.org/10.34024/rnc.2014.v22.8067.
Full textAbstract:
Objetivo. A Ayahuasca, administrada em forma de chá, é resultado da cocção entre Banisteriopsis caapi e Psychotria viridis para fins religiosos, tendo ação psicoativa. O objetivo deste estudo foi analisar quantitativamente corpos celulares no córtex cerebral de camundongos sob o uso do extrato de Ayahuasca. Método. Foram utilizados 15 camundongos, divididos em três grupos: grupo controle (G1), tratado com solução fisiológica por 15 dias; G2 tratado com uma única dose do extrato de ayahuasca e G3 tratado com o extrato de ayahuasca durante 15 dias consecutivos, na dose padrão para os dois grupos experimentais de 30 mg/ml. Foi confirmada a presença de alcaloides no chá de Ayahuasca e a análise da quantidade de corpos celulares de neurônios foi realizada com o auxílio de um Sistema de Analisador de Imagens. Resultados. Não haver diferenças entre a quantidade dos corpos celulares no córtex cerebral do G1 em relação aos grupos G2 e G3. Conclusão. A utilização do chá de Ayahuasca na dose e tempo utilizados neste experimento, não causaram nenhum tipo de alteração quantitativa de corpos celulares de neurônios no córtex cerebral dos camundongos.
24
Silva, L., and L. Bravo. "Possible Therapeutics Effects of Ayahuasca, a Psychedelic Compound." European Psychiatry 65, S1 (June 2022): S871—S872. http://dx.doi.org/10.1192/j.eurpsy.2022.2260.
Full textAbstract:
Introduction Ayahuasca is an hallucinogenic tea prepared from the Amazonian vine Banisteriopsis caapi and the leaves of the plant Psychotria Viridis. Banisteriopsis caapi contains monoamine oxidase inhibitors (MAO) that render the N, N-dimethyltryptamine (DMT) of Psychotria Viridis active. This brew is being used as a sacrament in syncretic religions in urban areas of Brazil and worldwide with the purpose of enabling a spiritual experience as well as healing for a variety of conditions such as drug addiction, depression and anxiety disorders. Objectives This work aims to provide an understanding on the potential benefits of ayahuasca in psychiatric symptoms, as well as its neuropsychological functioning, neuroimaging and adverse events. Methods A non-systematic review was performed on PubMed database and Google Scholar, using the key words “Ayahuasca, Drug Addiction, Psychedelics, DMT, Neuroplasticity”. The review included experimental studies in humans, observational studies, systemic review articles and clinical trials. Results In a randomized placebo-controlled trial, ayahuasca had a significant antidepressant effect when compared to the placebo group. Long term ayahuasca usage was associated with structural alterations in the medial parts of the brain with no evidence of increased psychopathology or worse neuropsychological functioning. According to reviewed studies the incident of prolonged psychotic reaction among ayahuasca users is rare and the causal relation with ayahuasca is sometimes difficult to establish. Conclusions Despite the promising results, more controlled double-blinded studies with larger populations are necessary to better understand the therapeutic potentials and side effects of ayahuasca. Disclosure No significant relationships.
25
Palhano-Fontes, Fernanda, Dayanna Barreto, Heloisa Onias, Katia C. Andrade, Morgana M. Novaes, Jessica A. Pessoa, Sergio A. Mota-Rolim, et al. "Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial." Psychological Medicine 49, no. 4 (June 15, 2018): 655–63. http://dx.doi.org/10.1017/s0033291718001356.
Full textAbstract:
AbstractBackgroundRecent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression.MethodsTo test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating scale at baseline, and at 1 (D1), 2 (D2), and 7 (D7) days after dosing.ResultsWe observed significant antidepressant effects of ayahuasca when compared with placebo at all-time points. MADRS scores were significantly lower in the ayahuasca group compared with placebo at D1 and D2 (p= 0.04), and at D7 (p< 0.0001). Between-group effect sizes increased from D1 to D7 (D1: Cohen'sd= 0.84; D2: Cohen'sd= 0.84; D7: Cohen'sd= 1.49). Response rates were high for both groups at D1 and D2, and significantly higher in the ayahuasca group at D7 (64%v.27%;p= 0.04). Remission rate showed a trend toward significance at D7 (36%v.7%,p= 0.054).ConclusionsTo our knowledge, this is the first controlled trial to test a psychedelic substance in treatment-resistant depression. Overall, this study brings new evidence supporting the safety and therapeutic value of ayahuasca, dosed within an appropriate setting, to help treat depression. This study is registered athttp://clinicaltrials.gov(NCT02914769).
26
Rojas-Bolívar, Daniel E. "Ayahuasca: el encuentro de dos paradigmas." Revista de Neuro-Psiquiatria 77, no. 1 (March 31, 2014): 40. http://dx.doi.org/10.20453/rnp.v77i1.1162.
Full textAbstract:
La ayahuasca es una liana que crece en la Amazonía y con la cual se prepara una sustancia con potentes propiedades psicoactivas, también denominada ayahuasca. Esta sustancia está ligada con la cosmovisión de los pueblos amazónicos que la consideran una planta espiritual y medicinal por las visiones y percepción de los efectos que produce. Las investigaciones en laboratorio muestran que la ayahuasca contiene derivados betacarbolínicos como la harmina y derivados triptamínicos como la N,N-dimetiltriptamina (DMT), moléculas que intervienen en determinados fenómenos psicodislépticos de tipo alucinatorio -visiones de seres sobrenaturales- junto a alteraciones de la conciencia del yo descritas como una sensación de muerte y renacimiento que pueden llevan al usuario de la ayahuasca a un estado de éxtasis espiritual y bienestar. Estos efectos han sido descritos en la literatura y se ha considerado el potencial terapéutico de la ayahuasca frente a trastornos del estado de ánimo y problemas adictivos en los cuales se han reportado algunos resultados favorables. Sin embargo, los efectos psicoactivos que genera la ayahuasca son complejos debido a sus aspectos subjetivos, sociales y culturales y por consiguiente son difíciles de abordar objetivamente en el marco del paradigma científico actual. Por tales motivos resulta necesario el replanteamiento de formas alternativas de investigación que puedan interpretar la subjetividad presente en la experiencia psicoactiva por uso de ayahuasca.
27
Boas, João Maria de Bragança Vasconcelos Vilas. "A UTILIZAÇÃO DA AYAHUASCA NO TRATAMENTO DE PERTURBAÇÕES PSIQUIÁTRICAS: UMA REVISÃO DA LITERATURA." Revista Contemporânea 3, no. 4 (April 17, 2023): 3186–95. http://dx.doi.org/10.56083/rcv3n4-026.
Full textAbstract:
A Ayahuasca é uma poderosa bebida psicoativa que tem sido usada há séculos por comunidades indígenas na América do Sul para fins espirituais e medicinais. A bebida é feita fervendo o cipó da ayahuasca (Banisteriopsis caapi) e as folhas da planta chacrona (Psychotria viridis), criando uma potente experiência psicadélica que pode durar várias horas. Nos últimos anos, tem havido um interesse crescente no uso da ayahuasca como potencial tratamento, para perturbações psiquiátricas. Os mecanismos pelos quais a ayahuasca pode exercer os seus efeitos antidepressivos e ansiolíticos não são totalmente compreendidos. No entanto, alguns investigadores sugeriram que a bebida pode atuar em vários sistemas de neurotransmissores, incluindo os sistemas serotoninérgicos, dopaminérgicos e glutamatérgicos. Embora estudos preliminares tenham mostrado resultados promissores no tramento de depressão, ansiedade, stress pós-traumático (PTSD) e abuso de substâncias, mais estudos são necessários para entender os potenciais benefícios e riscos do uso da ayahuasca, num ambiente clínico. Além disso, são necessários esforços para padronizar doses e métodos de preparação, e para enfrentar as barreiras legais e regulatórias, a fim de garantir o uso seguro e eficaz da ayahuasca, no tratamento de perturbações psiquiátricas.
28
Pinilla, R., C. Rodriguez, D. Batet-Sanchez, and B. Ordoñez. "Ayahuasca potential benefits." European Psychiatry 64, S1 (April 2021): S772. http://dx.doi.org/10.1192/j.eurpsy.2021.2043.
Full textAbstract:
IntroductionAyahusca has potential therapeutic beneffits.ObjectivesExpose the potential beneffits of ayahuasca from neuropharmacology and clinical existing evidence.MethodsA literature review was carried out in the databases pubmed, clinical key and texts of scientific dissemination.Results There´s scientific literature about the potential therapeutic use of ayahuasca in dependencies, anxiety symtoms and depression, near death experiences and terminal illnesses. Possible benefit is postulated in impulsivity and personality disorders. It induces an introspective state, triggered by thoughts, emotions and autobiographical memories, which promotes reflection on personal issues, allowing new perspectives on certain life issues. It is common for users to describe it as analogous to a psychotherapeutic intervention. 5HTA2 agonists stimulate the expression of genes that encode transcription factors such as c-fos, egr 1, egr 2 and brain-derived neurotrophic factor (BDNF), which influence neuronal plasticity and are associated with cognitive aspects such as memory and attention. MAOIs and 5HT2A agonism have anxiolytic and antidepressant effects. Sigma -1 agonism promotes neuroplasticity. Decrease and remission in the consumption of alcohol and cocaine has been reported in patients with abuse and dependence. There has been significant decrease in depressive symptomatology, in observational studies, cases and controls and double blind compared with placebo. Improvement in different domains measured with mindfulness scales, similar to those observed in meditators, suggests an association between mindfulness techniques and experiences with ayahuasca.ConclusionsThere is existing evidence about potential therapeutical uses of ayahuasca. More studies are needed with biger samples, to establish it´s clinical use.DisclosureNo significant relationships.
29
Wright, Robin. "Brazilian Ayahuasca Religions." Fieldwork in Religion 2, no. 2 (April 12, 2008): 177–86. http://dx.doi.org/10.1558/fiel2008v2i2.177.
Full textAbstract:
This article reviews the forthcoming issue of FIR containing an important collection of articles on the origins and developments of religious movements and, later, research movements focused on a powerful psychoactive beverage consisting of the mixture of certain vines (ayahuasca) and leaves (chacrona) found mainly in Western Amazonia. The religious interpretations resulting from the ritual ingestion of the beverage have produced the most varied practices and beliefs, beginning with the indigenous peoples and mestizo herbalists, then migrant rubber-tappers from northeastern Brazil; in the 1960s, urbanites from major cities in Brazil and Europe seeking alternative forms of religious inspiration; and, in the 1990s, a group of Brazilian researchers who have combined anthropological and religious understanding of the phenomena along with legal expertise for the protection of the religious freedom necessary for the religions’ developments. With the diversification and globalization of these new religious movements, the article points to new directions for field research in these religions.
30
Doyle, Richard. "Hyperbolic: Divining Ayahuasca." Discourse 27, no. 1 (2005): 6–33. http://dx.doi.org/10.1353/dis.2006.0005.
Full text
31
Shukla, Chetna. "Ayahuasca A Proving." Homoeopathic Links 26, no. 01 (March 11, 2013): 24. http://dx.doi.org/10.1055/s-0032-1328167.
Full text
32
de Pablo Márquez, Bernat, and Beatriz Dietl Gómez-Luengo. "Intoxicación por ayahuasca." Medicina Clínica 149, no. 3 (August 2017): 136–37. http://dx.doi.org/10.1016/j.medcli.2017.02.017.
Full text
33
dos Santos, Rafael G., José Carlos Bouso, and Jaime E. C. Hallak. "Intoxicación por ayahuasca." Medicina Clínica 149, no. 10 (November 2017): 461–62. http://dx.doi.org/10.1016/j.medcli.2017.04.032.
Full text
34
Anderson, Brian T., Beatriz C. Labate, Matthew Meyer, Kenneth W. Tupper, Paulo C. R. Barbosa, Charles S. Grob, Andrew Dawson, and Dennis McKenna. "Statement on ayahuasca." International Journal of Drug Policy 23, no. 3 (May 2012): 173–75. http://dx.doi.org/10.1016/j.drugpo.2012.02.007.
Full text
35
Silva, Ana Karoline Pontes da, Sabrina da Silva Barbosa, and Natasha Cristina Silva da Silva. "Evidências sobre os efeitos antidepressivos da Ayahuasca: uma revisão integrativa." Research, Society and Development 11, no. 16 (November 30, 2022): e90111637981. http://dx.doi.org/10.33448/rsd-v11i16.37981.
Full textAbstract:
Objetivo: Explorar a natureza das evidências que comprovam efeitos antidepressivos do chá de ayahuasca com base em estudos científicos que demonstraram resultados satisfatórios. Metodologia: Consiste em uma revisão integrativa com foco em analisar artigos publicados entre 2016 a 2022 encontrados nas bases de dados virtuais: LILACS, PubMed, SciELO e Science Direct utilizando os descritores: “ayahuasca, ayahuasca depressão, ayahuasca farmacologia, Banisteriopsis caapi, Psychotria viridis”. Resultados: No período de busca inicial foram encontrados 1.402 artigos, sendo 106 destas publicações potencialmente elegíveis de acordo com os critérios de inclusão e exclusão adotados na revisão, após a leitura dos resumos restaram 37 e desses apenas 4 foram os escolhidos para compor o corpus de análise. Sendo possível concluir que o uso da ayahuasca em pacientes com depressão mostrou-se um recurso considerável de origem vegetal que pode contribuir para o enfrentamento desta doença. Sendo ainda necessários estudos mais aprofundados a serem realizados com o chá.
36
Silva, Drance Elias, and João Paulo Reis Braga. "AYAHUASCA: UM SAGRADO SELVAGEM QUE BASTIDE NÃO CONHECEU." PARALELLUS Revista de Estudos de Religião - UNICAP 10, no. 23 (December 2, 2019): 019. http://dx.doi.org/10.25247/paralellus.2019.v10n23.p019-039.
Full textAbstract:
A Ayahuasca é uma bebida enteógena feita por meio da união de duas plantas: um cipó chamado Mariri (Banisteriopsis caapi) e as folhas de uma árvore chamada Chacrona (Psychotria viridis). O Chá Ayahuasca vem sendo usado há milhares de anos em rituais religiosos indígenas, e há algumas décadas em religiões urbanas como o Santo Daime e a União do Vegetal. A Ayahuasca é considerada uma bebida sagrada por todos que a utilizam regularmente em contexto religioso. Roger Bastide foi um teórico francês, que veio para o Brasil em 1938 e estudou durante muitos anos as religiões afro-brasileiras, dando enfoque a fenômenos como: a administração do sagrado, o sentimento de vergonha, e o processo de “domesticação” e persistência do “sagrado selvagem”. O presente artigo analisou também o conceito bastidiano de transe como “um jogo litúrgico”, que segundo ele, aproxima-se de uma “representação teatral”. As conclusões desse artigo sugerem que o transe provocado pela Ayahuasca transcende algumas das premissas bastidianas. Os resultados demonstraram ainda que as considerações que Bastide faz a respeito do processo de “domesticação do sagrado selvagem” podem ser observadas em religiões ayahuasqueiras como a União do Vegetal, ainda que em alguns pontos, a realidade da instituição não esteja em total consonância com as previsões feitas por Bastide.Palavras-chave: Ayahuasca. Bastide. Sagrado Selvagem. Transe Religioso. Enteógeno AYAHUASCA: A WILD SACRED WHICH BASTIDE DID NOT KNOWAbstractAyahuasca is an entheogenic drink made by the union of two plants: a vine called Mariri (Banisteriopsis caapi) and the leaves of a tree called Chacrona (Psychotria viridis). Ayahuasca tea has been used for thousands of years in indigenous religious rituals, and for decades in urban religions such as Santo Daime and União do Vegetal. Ayahuasca is considered a sacred drink by all who use it regularly in a religious context. Roger Bastide was a French theorist, who came to Brazil in 1938 and studied for many years the Afro-Brazilian religions, focusing on phenomena such as: the administration of the sacred, the feeling of shame, and the process of "domestication" and persistence of the "wild sacred". The present article also analyzed the Bastidian concept of trance as "a liturgical game", which he said, approaches a "theatrical representation". The conclusions of this article suggest that the trance provoked by Ayahuasca transcends some of the bastidian premises. The results also demonstrated that Bastide's considerations regarding the process of "domestication of the wild sacred" can be observed in ayahuasca religions like União do Vegetal, although in some points, the reality of the institution is not in total harmony with the predictions made by Bastide.Keywords: Ayahuasca; Roger Bastide; Wild Sacred; Religious Transe; Entheogen.
37
Lima, Vinícius Maurício de. "Usos da ayahuasca e discursos sobre transtornos mentais na imprensa brasileira 1960-2010." Ciencias Sociales y Religión 25 (December 19, 2023): e023018. http://dx.doi.org/10.20396/csr.v25i00.8671997.
Full textAbstract:
Historicamente, a ayahuasca é associada na imprensa à “alucinação”, às “drogas” e à “loucura”. No entanto, o avanço de pesquisas sobre seus “potenciais terapêuticos” e a divulgação dos resultados no noticiário fazem questionar, o que também é uma premissa, se há uma transformação nos significados sociais da beberagem em um período recente. O objetivo deste artigo foi analisar a cobertura dos veículos de imprensa em relação aos usos da ayahuasca e os discursos sobre transtornos mentais. Nos termos de Latour, esses veículos são ‘atores’ fundamentais em uma rede sociotécnica da ayahuasca que integra com outros atores e com os quais estabelece “associações” e “controvérsias” no debate público. Para tanto, foi realizada uma análise dos discursos sobre transtornos mentais relacionados aos usos da ayahuasca em reportagens de veículos do Brasil, nacionais e da região Amazônica, dos anos 1960 a 2020. Esses documentos evidenciam mudanças de abordagem, nas narrativas e gramáticas que vêm legitimando a ayahuasca recentemente em relação a décadas anteriores.
38
Moura, Alexandre Machado de, Marcela Barboza de Melo Aragão, Dario César de Oliveira Conceição, and Karoline Belém Seixas. "Eficácia terapêutica da ayahuasca em pacientes com transtornos mentais baseada em estudos clínicos: uma revisão integrativa." Research, Society and Development 11, no. 4 (March 16, 2022): e22211427182. http://dx.doi.org/10.33448/rsd-v11i4.27182.
Full textAbstract:
Objetivo: Investigar evidências terapêuticas da Ayahuasca, que é uma bebida psicoativa obtida da decocção de duas plantas de origem amazônica: Banisteriospsis caapi (cipó Mariri) e Psychotria viridis (Chacrona), comprovadas em estudos clínicos controlados em pacientes com transtornos psiquiátricos. Metodologia: Trata-se de uma revisão integrativa da literatura focada em ensaios clínicos disponíveis nas bases de dados eletrônicas MEDLINE (Pubmed-AdvancedSearch), Trip data base e Lilacs por meio dos descritores “Ayahuasca, tratamento”; “Ayahuasca, estudo clínico”; “Ayahuasca, tratamento psiquiátrico”. Resultados: Foram selecionados 8 artigos publicados entre 2015 e 2021. Seis estudos avaliaram o uso da Ayahuasca no tratamento do transtorno depressivo recorrente, e dois verificaram a relação entre a Ayahuasca e a redução do risco de suicídio em pacientes com depressão recorrente. A bebida apresentou efeitos antidepressivos rápidos e sustentados, melhorando sintomas de depressão, ligados ou não a pensamentos suicidas. Considerações Finais: Considerando os efeitos colaterais e o tempo necessário para a remissão dos sintomas dos tratamentos atuais, é preciso considerar o potencial de tratamentos alternativos e inovadores para pacientes que não se adaptam aos métodos convencionais. Os resultados demonstrados nesta pesquisa precisam ser replicados em estudos maiores, e com acompanhamento mais duradouro, para avaliar a eficácia e a segurança da substância a longo prazo.
39
Ueno, Thalyta Mariany Rêgo Lopes, Naelly Gonçalves Nascimento, Marisa Melo de Souza, Ianny Ferreira Raiol Sousa, Juliana Conceição Dias Garcez, and Alex Martins. "Ayahuasca e as pesquisas relacionadas ao contexto religioso: revisão integrativa." Research, Society and Development 11, no. 17 (December 19, 2022): e18111738784. http://dx.doi.org/10.33448/rsd-v11i17.38784.
Full textAbstract:
O estudo tem como objetivo identificar pesquisas na área da saúde sobre o uso da ayahuasca relacionadas ao contexto religioso, no período de 2017 a 2021. Pesquisa descritiva, do tipo Revisão Integrativa da Literatura (RIL). Como critério de inclusão utilizou-se artigos disponíveis no idioma português, inglês e espanhol, artigos completos e que estivessem entre os anos de 2017 a 2021. As bases de dados utilizadas foram Biblioteca Virtual em Saúde (BVS) e PubMed. A coleta de dados foi realizada por meio do formulário de Ursi adaptado e a análise de dados por meio de Bardin. Foram selecionados 9 artigos. A análise quantitativa identificou 6 (66,6%) na pubmed e a maioria do ano de 2020. Foram construídos principalmente por farmacêuticos 4 (44,4%). A partir da análise qualitativa elencou-se quatro categorias temática: Ayahuasca e o tratamento para dependência química; Ayahuasca no tratamento dos transtornos psicológicos; A legitimidade e a preocupação com a comercialização da ayahuasca; Ayahuasca e Espiritualidade. A RIL permitiu identificar evidências científicas nacionais e internacionais sobre o uso da ayahuasca no contexto religioso, desta maneira, possibilitou alcançar o objetivo da pesquisa. Apesar de ainda ser considerado um assunto pouco discutido e estigmatizado, os artigos permitiram a identificação de achados relevantes.
40
Cowley-Court, Tessa, Richard Chenhall, Jerome Sarris, José Carlos Bouso, Luís Fernando Tófoli, Emérita Sátiro Opaleye, Violeta Schubert, and Daniel Perkins. "Life after Ayahuasca: A Qualitative Analysis of the Psychedelic Integration Experiences of 1630 Ayahuasca Drinkers from a Global Survey." Psychoactives 2, no. 2 (June 13, 2023): 201–21. http://dx.doi.org/10.3390/psychoactives2020014.
Full textAbstract:
Ayahuasca is an Amazonian psychoactive plant medicine being explored for its potential therapeutic uses in Western contexts. Preliminary studies link ayahuasca use with improvements across a range of mental health indicators, but studies have not yet explored qualitative aspects of the post-treatment process known in the psychedelic literature as “integration”. This includes how participants make sense of their ayahuasca experiences and minimise harm/maximise benefits after ayahuasca use. A global online survey, conducted between 2017 and 2019, collected responses from 1630 ayahuasca drinkers (50.4% male, mean age = 43 years) to an open-ended question about their integration experiences after consuming ayahuasca. Inductive codebook thematic analysis was used to identify themes in participants’ integration experiences. Participants described integration experiences in three main ways. First, was an overall appraisal of the integration experience (e.g., as easy, challenging, or long-term/ongoing). Second, was describing beneficial tools which facilitated integration (e.g., connecting with a like-minded community and ongoing practice of yoga, meditation, journaling, etc.). Third, was describing integration challenges (e.g., feeling disconnected, going back to “old life” with new understandings, etc.). These findings suggest that integrating ayahuasca experiences can be challenging and take considerable time, though working through integration challenges may facilitate positive growth. Findings also challenge the role of individual psychotherapy as the primary integration tool in Western psychedelic therapy, suggesting that communal and somatic elements may also be useful. An expanded definition of psychedelic integration is proposed which includes working with integration challenges and adjusting to life changes.
41
Khubsing, Rishma S. I., Martin van Leerdam, Eline C. H. M. Haijen, and Kim P. C. Kuypers. "Self-Rated Effectiveness of Ayahuasca and Breathwork on Well-Being, Psychological Resilience, Self-Compassion, and Personality: An Observational Comparison Study." Psychoactives 3, no. 2 (March 31, 2024): 167–83. http://dx.doi.org/10.3390/psychoactives3020011.
Full textAbstract:
Background: In recent years, there has been a growing interest in the therapeutic potential of classical psychedelics like ayahuasca for mental health improvement. Naturalistic studies at ayahuasca retreats have shown (short-term) improvements in mental well-being but understanding the psychological mechanisms is crucial. We are interested in psychological processes such as resilience, self-compassion, and personality traits. Additionally, it is unclear whether changes are solely due to ayahuasca or influenced by the social setting. To address this, a control group participating in a breathwork session, similar to ayahuasca retreats, was included. Methods: In this observational study, individuals who attended an ayahuasca retreat (n = 69) and individuals who participated in a breathwork session (n = 30) completed an online survey one week before (baseline) and one, six, and twelve weeks after they entered the retreat/session. The survey included a series of questionnaires, i.e., the World Health Organisation-Five Well-Being Index, 14-item Resilience Scale, Self-Compassion Scale–Short Form, and Big Five Inventory-10. A linear mixed model (LMM) was used to analyze the outcome data. Results: It was shown that well-being, resilience, and self-compassion increased and remained stable over 12 weeks compared to baseline, regardless of group (ayahuasca or breathwork). Older participants generally reported higher resilience and self-compassion. Self-compassion was also higher in the ayahuasca group overall. Neuroticism decreased in both groups, with lower scores in the ayahuasca group. Agreeableness increased over time, also not influenced by group membership, while there were no changes in extraversion, conscientiousness, or openness. Discussion: Both interventions improved well-being, aligning with prior research. Importantly, this study unveils a novel finding: both interventions enhance resilience and self-compassion for up to three months, offering promise for conditions marked by low well-being, resilience, and self-compassion like depression and anxiety-related disorders. While acknowledging its limitations (e.g., self-selected sample, no specific information of the ayahuasca brew or the breathwork technique), it emphasizes the need for controlled studies with control groups, attention to social contexts in research on these interventions, and to assess other variables like depth of altered states of consciousness that might explain improvement in psychological processes and wellbeing.
42
De Oliveira, Josemeire Coimbra, Paula Valeria Cordeiro Lima, and Keylla dos Santos Pádua. "OS POTENCIAIS TERAPÊUTICOS DA AYAHUASCA NO TRATAMENTO DE DEPRESSÃO E ANSIEDADE." Revista Contemporânea 2, no. 6 (December 9, 2022): 1448–57. http://dx.doi.org/10.56083/rcv2n6-024.
Full textAbstract:
O presente trabalho apresentado em forma de revisão de literatura tem como finalidade verificar indícios sobre o potencial terapêutico da ayahuasca no tratamento da depressão e ansiedade. A Ayahuasca é uma beberagem de origem indígena utilizada em rituais religiosos e o seu chá consiste na infusão do cipó Banisteriopsis caapi e folhas de arbusto Psycotria viridis. Para estas civilizações primitivas a bebida é utilizada com o intuito de limpeza e devido a isso começou a ser amplamente utilizado em tratamentos ritualísticos para problemas e transtornos psicológicos. Esta pesquisa seguiu os princípios de uma revisão narrativa e não acarreta constrangimento ético. A pesquisa foi feita nas bases de dados LILACS, PUBMED E SCIELO. Foram utilizados os seguintes descritores: Uso terapêutico, Ayahuasca e Potencial terapêutico. Entre os artigos supracitados foi evidenciado que não houve relatos negativos a cerca do uso da ayahuasca e que houve uma diminuição da sintomatologia de usuários acometidos pelos transtornos de depressão e ansiedade. No entanto, torna -se necessário mais estudos que comprovem o efeito terapêutico da ayahuasca em tratamentos psicológicos.
43
Brito-da-Costa, Andreia Machado, Diana Dias-da-Silva, Nelson G. M. Gomes, Ricardo Jorge Dinis-Oliveira, and Áurea Madureira-Carvalho. "Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact." Pharmaceuticals 13, no. 11 (October 23, 2020): 334. http://dx.doi.org/10.3390/ph13110334.
Full textAbstract:
Ayahuasca is a hallucinogenic botanical beverage originally used by indigenous Amazonian tribes in religious ceremonies and therapeutic practices. While ethnobotanical surveys still indicate its spiritual and medicinal uses, consumption of ayahuasca has been progressively related with a recreational purpose, particularly in Western societies. The ayahuasca aqueous concoction is typically prepared from the leaves of the N,N-dimethyltryptamine (DMT)-containing Psychotria viridis, and the stem and bark of Banisteriopsis caapi, the plant source of harmala alkaloids. Herein, the toxicokinetics and toxicodynamics of the psychoactive DMT and harmala alkaloids harmine, harmaline and tetrahydroharmine, are comprehensively covered, particularly emphasizing the psychological, physiological, and toxic effects deriving from their concomitant intake. Potential therapeutic utility, particularly in mental and psychiatric disorders, and forensic aspects of DMT and ayahuasca are also reviewed and discussed. Following administration of ayahuasca, DMT is rapidly absorbed and distributed. Harmala alkaloids act as potent inhibitors of monoamine oxidase A (MAO-A), preventing extensive first-pass degradation of DMT into 3-indole-acetic acid (3-IAA), and enabling sufficient amounts of DMT to reach the brain. DMT has affinity for a variety of serotonergic and non-serotonergic receptors, though its psychotropic effects are mainly related with the activation of serotonin receptors type 2A (5-HT2A). Mildly to rarely severe psychedelic adverse effects are reported for ayahuasca or its alkaloids individually, but abuse does not lead to dependence or tolerance. For a long time, the evidence has pointed to potential psychotherapeutic benefits in the treatment of depression, anxiety, and substance abuse disorders; and although misuse of ayahuasca has been diverting attention away from such clinical potential, research onto its therapeutic effects has now strongly resurged.
44
Santos, Beatriz Werneck Lopes, Regina Célia de Oliveira, Julia Sonsin-Oliveira, Christopher William Fagg, José Beethoven Figueiredo Barbosa, and Eloisa Dutra Caldas. "Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential." Plants 9, no. 7 (July 9, 2020): 870. http://dx.doi.org/10.3390/plants9070870.
Full textAbstract:
Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoamine oxidase inhibitors β-carbolines, and Psichotria virids, which contains the serotonin receptor agonist N,N dimethyltryptamine (DMT). The objectives of this study were to investigate the chemical profile of B. caapi and of ayahuasca collected in various Brazilian regions. In total, 176 plant lianas, of which 159 B. caapi and 33 ayahuasca samples were analyzed. Dried liana samples were powdered, extracted with methanol, diluted, and analyzed by LC-MS/MS. Ayahuasca samples were diluted and analyzed. Mean concentrations in B. caapi were 4.79 mg/g harmine, 0.451 mg/g harmaline, and 2.18 mg/g tetrahydroharmine (THH), with a high variability among the samples (RSD from 78.9 to 170%). Native B. caapi samples showed significantly higher harmine concentrations than cultivated ones, and samples from the Federal District/Goiás had higher THH content than those collected in the State of Acre. The other Malpighiaceae samples did not contain β-carbolines, except for one D. pubipetala sample. Concentrations in ayahuasca samples ranged from 0.109 to 7.11 mg/mL harmine, 0.012 to 0.945 mg/mL harmaline, 0.09 to 3.05 mg/mL THH, and 0.10 to 3.12 mg/mL DMT. The analysis of paired ayahuasca/B. caapi confirmed that harmine is reduced to harmaline and to THH during the brew preparation. This is the largest study conducted with Malpighiaceae samples and showed a large variability in the main β-carbolines present in B. caapi. This biodiversity is a challenge for standardization of the material used in ethnopharmacological studies of B. caapi and ayahuasca.
45
Álvarez Cortez, Franklin Andrés, and Daicy Paola Arias Salazar. "Implementación de un producto natural a partir de Ayahuasca (banisteriopsis caapi) en la sustitución de antidepresivos sintéticos." Ciencia Latina Revista Científica Multidisciplinar 7, no. 2 (April 11, 2023): 2424–37. http://dx.doi.org/10.37811/cl_rcm.v7i2.5499.
Full textAbstract:
En la actualidad el uso excesivo de antidepresivos de origen químico en el Ecuador ha aumentado en los últimos años, con el tiempo el abuso de antidepresivos, bloquea la acción del neurotransmisor que es el responsable de mantener en equilibrio el estado de ánimo (serotonina), ocasionando en las personas altos niveles de depresión y ansiedad, derrames o lesiones cerebrales, pérdida de memoria e incluso pueden llegar a la muerte. Según la Organización Mundial de la Salud (OMS) cada año mueren 1200 millones de personas por el uso excesivo de antidepresivos químicos, donde se ha demostrado que los jóvenes son los más propensos en sufrir problemas de salud mental (depresión, ansiedad y tristeza) debido a una mala alimentación (obesidad), bullying escolar o en el trabajo y por el consumo de alcohol y drogas. Desarrollar la propuesta de desarrollar un producto natural con ayahuausca (Banisteriopsis caapi) para sustituir antidepresivos sintéticos, permitirá evitar dependencia en los pacientes. Se desarrolló mediante el análisis de las personas que sufren de depresión y ansiedad, pues que previene la ruptura de la serotonina; debido a los alcaloides (la harmina y tetrahidroharmina) que contiene esta planta natural, obteniendo un jarabe natural a partir de la Ayahuasca. Se comprobó la utilidad de la ayahuasca en el tratamiento natural de la depresión y ansiedad.
46
Gonçalves, Joana, Ângelo Luís, Eugenia Gallardo, and Ana Paula Duarte. "Evaluation of the In Vitro Wound-Healing Potential of Ayahuasca." Molecules 27, no. 18 (September 6, 2022): 5760. http://dx.doi.org/10.3390/molecules27185760.
Full textAbstract:
Ayahuasca is an Amazonian drink, which contains β-carboline alkaloids and N,N-dimethyltryptamine. The aim of this study was to evaluate the healing potential of decoctions of a commercial mixture, four individual plants and four mixtures of two plants used in the ayahuasca preparation. Thus, the cytotoxic potential of the samples was evaluated and a wound-healing assay was performed with a NHDF cell line. Subsequently, a parallel artificial membrane permeability assay was also performed, to verify if any psychoactive compound could be absorbed by skin fibroblasts. The integrity and permeability of the cell layer were also evaluated, using the transepithelial electrical resistance assay and Lucifer yellow permeability assay, respectively. The compounds absorbed by the cell layer were quantified by high-performance liquid chromatography coupled to a diode array detector. The results showed that only one sample showed cytotoxicity and all the others promoted the migration of skin fibroblasts. Additionally, it was also verified that β-carbolynic alkaloids and N,N-dimethyltriptamine were not absorbed by the cell layer, and in general, did not interfere with its permeability and integrity. To the best of our knowledge, this is the first study where ayahuasca’s wound-healing potential was evaluated.
47
Beyer, Stephan V. "Special Ayahuasca Issue Introduction: Toward a Multidisciplinary Approach to Ayahuasca Studies." Anthropology of Consciousness 23, no. 1 (March 2012): 1–5. http://dx.doi.org/10.1111/j.1556-3537.2012.01053.x.
Full text
48
Perkins, Daniel, Emerita Opaleye, Jose Carlos Bouso, Luis Fernando Tófoli, Jerome Sarris, Violeta Schubert, Simon Ruffell, and Hana Simonova. "Insights, Life Changes and Lifestyle Changes Reported by Individuals Consuming Ayahuasca in Naturalistic Settings: Nature, Frequency and Associations with Mental Health and Wellbeing." Psychoactives 2, no. 4 (October 3, 2023): 256–90. http://dx.doi.org/10.3390/psychoactives2040017.
Full textAbstract:
Background: In the context of increasing scientific interest in the potential therapeutic use of psychedelic agents and their underlying psychotherapeutic mechanisms, we undertake the first detailed assessment of insights and life and lifestyle changes associated with ayahuasca consumption. Methods: An international cross-sectional study of ayahuasca drinkers in a variety of settings was performed (n = 8907). Bivariate analysis and multivariate linear and logistic regressions were used to explore associations between a range of covariates and insights, life changes and lifestyle changes. The least absolute shrinkage and selection operator variable selection method (LASSO) was used to select the variables most relevant for inclusion in models assessing broader wellbeing and mental health associations. Results: Insights are almost universally reported as part of the ayahuasca experience and are highly valued by drinkers and strongly predictive of subsequent beneficial life and lifestyle changes. A range of personal, vocational, religious/spiritual and health-related life changes (attributed to ayahuasca) are also commonly identified, as are various beneficial lifestyle and health behavior changes. Demographic and ayahuasca drinking variables that are predictive of such phenomena are reported, along with associations between insights, life and lifestyle changes and perceived growth in psychological wellbeing and current mental health status (Kessler 10 and SF-12 MCS). Conclusion: Insights and subsequent life and lifestyle changes appear to have a central role in the transformative effects reported by individuals consuming ayahuasca, with these occurring across contexts of use and demographic groups.
49
Araújo, Sofia Azevêdo, and Daniely Ildegardes Brito Tatmatsu. "Pesquisas com Ayahuasca na Psicologia: Uma revisão de literatura sobre o potencial terapêutico." Revista de Psicologia 11, no. 2 (July 1, 2020): 116–21. http://dx.doi.org/10.36517/10.36517/revpsiufc.11.2.2020.12.
Full textAbstract:
A Ayahuasca é uma bebida alucinógena utilizada em contexto religioso, sendo associada a melhorias na saúde mental dos usuários. O presente estudo teve como objetivo fazer um levantamento da produção de pesquisas que avaliam o seu potencial terapêutico no campo da Psicologia. Foi realizada uma revisão narrativa de literatura com os descritores “Psicologia” e “Ayahuasca” indexados no portal CAPES, nas plataformas Medline e Scielo. Foram obtidos 34 artigos e foram aplicados critérios de inclusão – serem escritos nas línguas portuguesa ou inglesa, e possuírem o descritor “Ayahuasca” no título – e de exclusão – não abordarem o uso terapêutico da ayahuasca como problema de pesquisa. Após a filtragem, obteve-se 8 artigos publicados entre 2006 e 2018, divididos em 10 estudos, sendo 7 de pesquisa básica e 3 de pesquisa aplicada. Conclui-se que a produção de estudos sobre a eficácia terapêutica da Ayahuasca e seus efeitos na saúde mental dos usuários é recente e escassa. É importante que estudos futuros abordem além de parâmetros psicopatológicos ou farmacológicos questões sociais e culturais atrelados ao uso de substâncias. É essencial que particularidades do ambiente no qual a substância foi ingerida e da história de vida do usuário sejam consideradas e investigadas minunciosamente.
50
Pasquini, Lorenzo, Fernanda Palhano-Fontes, and Draulio B. Araujo. "Subacute effects of the psychedelic ayahuasca on the salience and default mode networks." Journal of Psychopharmacology 34, no. 6 (April 7, 2020): 623–35. http://dx.doi.org/10.1177/0269881120909409.
Full textAbstract:
Background: Neuroimaging studies have just begun to explore the acute effects of psychedelics on large-scale brain networks’ functional organization. Even less is known about the neural correlates of subacute effects taking place days after the psychedelic experience. This study explores the subacute changes of primary sensory brain networks and networks supporting higher-order affective and self-referential functions 24 hours after a single session with the psychedelic ayahuasca. Methods: We leveraged task-free functional magnetic resonance imaging data 1 day before and 1 day after a randomized placebo-controlled trial exploring the effects of ayahuasca in naïve healthy participants (21 placebo/22 ayahuasca). We derived intra- and inter-network functional connectivity of the salience, default mode, visual, and sensorimotor networks, and assessed post-session connectivity changes between the ayahuasca and placebo groups. Connectivity changes were associated with Hallucinogen Rating Scale scores assessed during the acute effects. Results: Our findings revealed increased anterior cingulate cortex connectivity within the salience network, decreased posterior cingulate cortex connectivity within the default mode network, and increased connectivity between the salience and default mode networks 1 day after the session in the ayahuasca group compared to placebo. Connectivity of primary sensory networks did not differ between groups. Salience network connectivity increases correlated with altered somesthesia scores, decreased default mode network connectivity correlated with altered volition scores, and increased salience default mode network connectivity correlated with altered affect scores. Conclusion: These findings provide preliminary evidence for subacute functional changes induced by the psychedelic ayahuasca on higher-order cognitive brain networks that support interoceptive, affective, and self-referential functions.