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Dissertations / Theses on the topic 'Azabicycles'

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Published: 4 June 2021

Last updated: 10 February 2022

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1

Bathgate, Antoinette. "Syntheses & reactions of azabicycles." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/33896.

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Several novel nitrogen containing bicyclic systems have been synthesised and their chemistry investigated. The kinetic and thermodynamic invertomer ratios of N-chloro-1,2,3,4-tetrahydro-2-keto-l, 4-iminonaphthalene derivatives were determined. The results suggested that a repulsive interaction existed between the positive end of the carbonyl dipole and the incoming electrophilic chlorine. Despite reaction under favourable solvolytic conditions, it appeared that homolysis of the N-chloroamines was favoured over heterolysis. Under conditions of negligible inversion, N-chloro-1,4-dihydro-1-methyl

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2

Boynton, Carole M. "Alkaloid synthesis via novel azabicycles." Thesis, Sheffield Hallam University, 1988. http://shura.shu.ac.uk/19384/.

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A basic introduction to pyrrolizidine and indolizidine alkaloids has been described along with a selection of recent syntheses of the said compounds. Cycloalkene synthesis by intramolecular Wittig reaction has been reviewed and we describe the utility of this strategy in the formation of nitrogen-bridgehead bicycles which can then be used in alkaloid synthesis. Our initial studies on the viability of this strategy in the synthesis of fused pyrrolidone systems employed a Wittig reaction between 5-acetylpyrrolidin-2-one and vinylphosphonium salts. A comparison was made between three different vi

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3

Shanahan, Stephen Edward. "Rearrangement reactions for the synthesis of allenamides and azabicycles." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427677.

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4

Belkacemi, Djaballah. "Synthesis, 15N NMR spectroscopy and cycloaddition reactions of some azabicycles." Thesis, University of Leicester, 1991. http://hdl.handle.net/2381/33951.

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The synthesis of 15N-enriched samples of derivatives of the 7-azabicyclo[2.2.1]heptyl system was achieved and 15N n.m.r, spectra were recorded both on enriched samples and, in some cases, at natural abundance. Signals corresponding to the two slowly-inverting isomers were seen in the N-methyl-7-azabicyclo[2.2.1]heptyl systems at low temperatures (-20 C). For the N-chloro-analogues, the nitrogen inversion was slower and the two invertomers could be seen at ambient temperature. The influence of substitution at the nitrogen atom, the effects of unsaturation and the presence of substituted aryl ri

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5

Seago, Amanda Jane Helen. "Studies towards the synthesis of pseudo-N-acetyl neuraminic acid." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365900.

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6

Ghirardi, Elena. "Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/398789.

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The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. Following the previous reported methodology a carbon substituent would be present at the carbocyclic ring and we planned to find the conditions for controlling its absolute configuration. Unfortunately, the reaction of ketoester 4 and ketoacid 7, provided undesired enamines 8 and 9. On the other hand, the reaction of ketoacid derivatives 16 and 17 with (R)-phenylglycinol led to a mixture of epi

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7

Edupuganti, Ramakrishna. "Asymmetric Synthesis of Homotropinone and Tropane Alkaloids using Enantiopure Sulfinimines and the Synthesis and Applications of Methanoprolines." Diss., Temple University Libraries, 2011. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/155171.

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Chemistry<br>Ph.D.<br>The development of new methodologies for the asymmetric synthesis of homotropinone and tropane alkaloids using enantiopure sulfinimines [RS(O)N=CR1R²] is the primary objective of this thesis. In one study a four-step intramolecular Mannich cyclization cascade reaction was devised for the asymmetric synthesis of substituted homotropinone alkaloids from enantiopure sulfinimine-derived N-sulfinyl ß-amino ketone ketals. These amino ketone ketal chiral building blocks were prepared in 67-71% yields and high dr (25-14:1) by addition of the Weinreb amide enolate of N-methoxy-Nme

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8

Maxwell, Christopher Reginald. "Chemistry of azabicyclo[2.2.1]heptanes." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312102.

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9

Murphy, James P. "Synthesis of azabicyclic intermediates for alkaloid synthesis." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394528.

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10

Bhonoah, Yunas. "7-Azabicyclo[2.2.1]heptanes in Natural Product Synthesis and Organocatalysis." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503845.

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11

Davies, J. W. "A study of some-strained azabicyclic compounds & their rearrangement reactions." Thesis, University of Leicester, 1985. http://hdl.handle.net/2381/34072.

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The barriers to nitrogen inversion were determined for several l-methyl-2-azabicyclo [2.1.1] heptyl systems. The rearrangement chemistry of the N-chloro derivative was investigated. This underwent silver-ion catalysed solvolysis to afford 4-methoxymethyl-2-methyl-l-pyrroline and also rearranged in the presence of alumina with retention of chlorine to give 2-methyl-2-chloro-l-azabicyclo [2.1.1] hexane, a novel ring system. The hydrochloride salt of this chlorine-retaining product rearranged with aqueous base to afford 4-hydroxymethyl-2-methyl-l-pyrroline. A study of 1,2,3,4-tetrafluoro-9,10-dih

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12

Smith, Craig. "Homotropanes : synthetic approaches to the 9-azabicyclo [4.2.1] nonane/ene ring system." Thesis, University of Leicester, 1992. http://hdl.handle.net/2381/33910.

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Homotropanes and homotrop-7-enes have been synthesised in reasonable yields by the method of intramolecular cyclisation of cis-1,4-aminocyclooctanols. The strategy of nitroso-cycloaddition to 1,3-cyclooctadiene provided the required cis-stereochemistry, and the choice of nitroso-compound determined the nitrogen protecting group of the resulting homotropane or homotrop-7-ene. A modification of the scheme led to the construction of the 1-methylhomotropane skeleton via intramolecular cyclisation of nitrogen onto an sp2 carbon of an exocyclic methylene group. A similar method was utilised to creat

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13

Al-Rubaye, Huda Ismail. "Synthesis of analogues of epibatidine based on the 2-azabicyclo[2.2.1]heptane system." Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42393.

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Epibatidine (exo-2-(6-chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane) is an alkaloid isolated from the skin of the Ecuadorian poison frog. It has been known since 1992 and has high binding affinity for nicotinic acetylcholine receptors. Many studies have reported epibatidine to possess analgesic properties, but it is also toxic even in low doses, thus, it cannot be used therapeutically. A wide range of epibatidine analogues have been studied in the hope of reducing their toxicity, and hence exploiting their therapeutic potential A general method for the synthesis of anti-7-functionalised 2-benzy

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14

Röper, Stefanie. "Studien zur diastereoselektiven Funktionalisierung der Cinchona-Alkaloide und Synthese enantiomerenreiner, funktionalisierter 1-Azabicyclo[3.2.2]nonane." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=966590236.

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15

Chen, Yao-Jung. "Secondary amine catalyzed-oximation of cyclopentanone and basicity and reactivity of 1-azabicyclo[2.2.1]heptane /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487265555441794.

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16

Kim, Zin Sig [Verfasser], and Dieter [Akademischer Betreuer] Enders. "Asymmetrische Synthese von 1,3-Aminoalkoholen und deren Anwendung zur Synthese von Azetidinen und 1-Azabicyclen / Zin Sig Kim ; Betreuer: Dieter Enders." Aachen : Universitätsbibliothek der RWTH Aachen, 2007. http://d-nb.info/1137488824/34.

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17

Pulipaka, Aravinda B. "Intramolecular Ring Opening Reactions of Aziridines by π-Nucleophiles". Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1205514895.

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18

Hensienne, Raphaël. "Nouvelles classes d’iminosucres bicycliques : approche synthétique des squelettes 5-azaspiro[3.4]octane et 6-azabicyclo[3.2.0]heptane." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF049/document.

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Des études antérieures conduites par notre groupe ont permis d’identifier l’α-1-C-nonyl-1,5-didésoxy-1,5-imino-D-xylitol en tant que puissant inhibiteur de la β-glucocérébrosidase – enzyme impliquée dans la maladie de Gaucher. La conformation inhabituelle (chaise inversée) de ce composé nous a incités à étudier plus avant la relation entre conformation et activité biologique des iminosucres. L’objectif de ces travaux de thèse consistait ainsi en la synthèse d’analogues conformationnellement contraints d’iminosucres. Dans un premier temps, trois spiro-iminosucres basés sur un squelette 5-azaspi

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19

Taylor, David. "Reactions of 2-azabicyclo[2.2.1] heptane systems and their application in the synthesis of peptide and amino acid analogues." Thesis, Heriot-Watt University, 2001. http://hdl.handle.net/10399/480.

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20

Masri, Fadi. "Synthèse de dérivés fonctionnalisés du 8-méthyl-8-azabicyclo[3. 2. 1]octane : vers de nouveaux marqueurs technétiés des transporteurs des monoamines." Université Joseph Fourier (Grenoble), 2003. http://www.theses.fr/2003GRE10029.

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21

Franz, Martin Heiko. "Diastereoselektive Synthesen funktionalisierter 1-Azabicyclo[3.2.2]nonane mechanistische Konzepte zur zweiten Cinchona-Umlagerung und Homologisierung an C9 der [beta]-Aminoalkohole Quincorin und Quincoridin /." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969347448.

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22

Hazm, Jamal Eddine. "Silicates et aluminosilicates microporeux obtenus en milieu fluoré avec, comme structurants, le 1,4-diazabicyclo [2,2,2] octane (DABCO) ou le 1-azabicyclo [2,2,2] octane (quinuclidine)." Mulhouse, 1992. http://www.theses.fr/1992MULH0238.

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Ce travail s'inscrit dans le cadre de l'exploration d'une nouvelle voie de synthèse hydrothermale des zéolithes. L'ion mobilisateur hydroxyde habituellement utilisé est ici remplacé par l'ion fluorure, avec pour corollaire l'emploi de milieux de synthèse de pH typiquement compris entre environ 7 et 10. L'utilisation de 2 structurants organiques différents, le 1,4-diazabicyclo [2,2,2] octane (« DABCO » ou le 1-azabicyclo [2,2,2] octane (« quinuclidine ») - combiné à des rapports molaires Si/Al variables - a permis respectivement la préparation des zéolithes bêta et de type MTW d'une part, ainsi

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23

Sumoreeah, Ravi Leckman. "Studies towards the total synthesis of galanthamine and the total synthesis of 2-Benzoyl-9-azabicyclo[4.2.1]non-2-ene : phenyl analogue of (#+-#)Anatoxin-a." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289225.

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This thesisd escribess yntheticw ork carriedo ut on two separatep rojects. (i) Synthetics tudiest owardst he total synthesiso f galanthamine (ii) The total synthesis of 2-Benzoyl-9-azabicyclo[4.2.1 ]non-2-ene Galanthamine is an amaryllidaceae alkaloid processing a rigid tetracyclic structure with a fused dihydrobenzofuran onto a cyclohexenol and a bridging tertiary amine. 2-Benzoyl-9-azabicyclo[4.2.1]non-2-ene is an analogue of anatoxin-a, whereby the acetyl side chain has been substituted with a benzoyl group. Anatoxin-a itself possesses a 9-azabicyclo[4.2.1]nonane framework. Although structu

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24

Tebben, Gerd-Dieter. "Intramolekulare Titan-vermittelte Aminocyclopropanierung als Zugang zu N-Benzyl-4-alkyl-2-azabicyclo[3.1.0]hexanen Synthese von tri- und tetrasubstituierten Alkenen durch Palladium-katalysierte Kreuzkupplung von Alkin-Titan-Komplexen /." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973961708.

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25

Berghian-, Groşan Ana Camelia. "Synthèse et stéréochimie de systèmes 3. 7-dioxa-1-azabicyclo[3. 3. 0]octaniques fonctionnalisés : Etude la métallation de bis-diazines et de diazines substituées par des groupements chélatants." Rouen, 2006. http://www.theses.fr/2006ROUES040.

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L’ensemble des travaux de recherche de cette thèse constitue des avancées dans différents domaines pour la synthèse et la fonctionnalisation des systèmes bicycliques 3. 7-DiOxa-r-AzaBicyclo[3. 3. 0]-c-5-Octanes (DOABO) et des diazines et benzo-diazines. Le chapitre 1 est consacré à une étude bibliographique sur la synthèse, la stéréochimie, la fonctionnalisation et les applications des DOABO et des diazines. Le chapitre 2 est relatif à la synthèse et à la stéréochimie d’une nouvelle classe de composés, les α-(3. 7-dioxa-r-1-azabicyclo[3. 3. 0]-oct-c-5-ylmethoxy)-di(s-tri)azines. La stéréochimi

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26

Riston, Jose Roberto. "Estudos visando a sintese estereosseletiva do alcaloide 275A." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249249.

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Orientador: Ronaldo Aloise Pilli<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-08T12:16:22Z (GMT). No. of bitstreams: 1 Riston_JoseRoberto_M.pdf: 1975890 bytes, checksum: 83dd322a0b88c53adac5195340f43a5f (MD5) Previous issue date: 2006<br>Resumo: Este trabalho trata de estudos visando à síntese estereosseletiva do alcalóide 275A (18, Figura 1). Esse alcalóide foi isolado por Daly e colaboradores da pele de pequenas rãs venenosas neotropicais da família Dendrobatidae em 1986. Sua estrutura possui um núcleo 1-azabicic

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27

Mehmandoust, Maryam. "Synthèse de dihydro-1, 2 pyridines et d'équivalents de sels de dihydro-2, 5 pyridinium à partir d'amines primaires chirales : application à la synthèse énantiosélective de dérivés d'isoquinuclidines et de pipéridines 2-substituées." Paris 11, 1989. http://www.theses.fr/1989PA112254.

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Une méthode générale de synthèse des sels de pyridinium N-substitués par différents auxiliaires chiraux, une application de la réaction de Zincke, à partir des amines primaires chirales correspondantes, est décrite. Par réduction au borohydrure de sodium en milieu alcalin, ces sels de pyridinium conduisent aux dihydro-1,2 pyridines correspondantes dont les réactions de cycloaddition avec l'acrylate de méthyle ont été étudiées. Des composés azabicyclo[2. 2. 2]octane (isoquinuclidines), dont la configuration absolue a été établie, sont obtenus avec des e. D. De 20 à 33% et une bonne pureté optiq

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28

Shanahan, Charles S. "Efforts towards the total synthesis of the stemofoline alkaloids utilizing a novel 1,3-dipolar cycloaddition reaction and application of the Pauson-Khand reaction as a novel entry into bridged azabicyclic ring systems." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-08-4101.

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A novel application of the Pauson-Khand reaction was applied to the synthesis of a series of bridged azatricyclic piperazines. This method represents the first application of the Pauson-Khand reaction to synthesize azabridged scaffolds. The ubiquity of bridged azabicyclic ring systems in biologically active natural product skeletons has provided the synthetic chemist with a wealth of opportunity for development over the last century. To this day, the development of new methodologies to tackle these structurally challenging systems remains at the forefront of synthetic chemistry. During our

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29

Slavik, Stefan. "Hochsubstituierte Azabicyclo[3.3.0]octane als Peptidmimetika." Phd thesis, 2005. http://tuprints.ulb.tu-darmstadt.de/594/1/Dissertation_Stefan_Slavik.pdf.

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Methoden zur asymmetrischen Synthese von Aza(poly)cyclen sind wertvolle Werkzeuge für das rationale Design potentieller Wirkstoffmoleküle. Im Rahmen dieser Arbeit sollte die von M. Reggelin entwickelte Sulfoximinauxiliar-basierte Methode zur asymmetrischen Synthese hochsubstituierter Aza(poly)cyclen strukturell und methodisch weiterentwickelt und auf die Synthese von potentiellen nichtpeptidischen Peptidmimetika angewandt werden. Im Hinblick auf mögliche Synthesen von Substanzbibliotheken wurde die Übertragung der aus γ-Hydroxyalkylierung und Michael-Addition bestehenden Synthesesequenz an lös

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30

Mthembu, Siyanda Thabani. "Enaminones in the synthesis of azabicyclic models for alkaloids." Thesis, 2008. http://hdl.handle.net/10539/5725.

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The purpose of this project was to investigate whether methodology developed in these laboratories for preparing 5/6 and 6/6 azabicyclic systems with bridged head nitrogen can be extended to 7/6, 8/6, 9/6 and 13/6 azabicyclic systems. The methodology entails the use of enaminones as central to the formation of the azabicyclic systems. The synthetic route adopted began with the Beckmann rearrangement reaction and/or the Schmidt reaction of cyclic ketones to make lactams, which were then thionated by Curphy or Brillon procedures. The Michael reaction of NH thiolactams with tert-butyl acr

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31

Goerz, Torsten. "6-Amino-3-azabicyclo[3.1.0]hexane : pharmazeutisch interessante Diamine /." 1998. http://www.gbv.de/dms/bs/toc/253577365.pdf.

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Slavik, Stefan [Verfasser]. "Hochsubstituierte Azabicyclo[3.3.0]octane als Peptidmimetika / vorgelegt von Stefan Slavik." 2005. http://d-nb.info/976098032/34.

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33

Li, Gaoquan. "The synthesis and electron transfer investigation of symmetric organic compounds containing 3-Keto-azabicyclo[3.3.1]non-9-yl and 3,7-Diketo-9-azabicyclo[3.3.1]non-9-yl systems." 2000. http://catalog.hathitrust.org/api/volumes/oclc/50037030.html.

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Thesis (M.S.)--University of Wisconsin--Madison, 2000.<br>Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 52-55).

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34

Morgans, Garreth Llewellyn. "New routes to arylated azabicyclic systems from enaminones, and applications to alkaloid synthesis." Thesis, 2009. http://hdl.handle.net/10539/6887.

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This thesis describes the application of enaminones towards the construction of azabicyclic systems. After a brief survey of indolizidine alkaloids bearing aromatic substituents an overview of the general strategies developed in laboratories at this University for the synthesis of alkaloids is given in Chapter 1. More specifically, the use of the Eschenmoser sulfide contraction for the construction of vinylogous amides is central to the work presented in this thesis. Syntheses of nitrile containing indolizidine systems are described in chapter 2. Preliminary reactions towards this goal

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35

Kühl, Jochen Eduard Wilhelm. "Synthese und Verwendung chiraler Sulfoximinauxiliare bei der Darstellung von Azabicyclo[3.3.0]octan-Peptidmimetika." Phd thesis, 2008. https://tuprints.ulb.tu-darmstadt.de/933/1/Dissertation_Jochen_Kuehl.pdf.

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Peptide übernehmen im menschlichen Organismus lebensnotwendige physiologische Funktionen. Wesentliche Voraussetzung für diese physiologische Funktion ist die komplementäre dreidimensionale Ausrichtung der Seitenketten der Effektoren und Rezeptoren durch die jeweiligen peptischen Rückgrate. Die peptidischen Strukturen, die diese Ausrichtung herbeiführen, stellen aber außerhalb der nativen Umgebung der Peptide deren „pharmakologische Achillesferse“ dar, da sie sowohl hydrolytisch als auch enzymatisch gespalten werden können. Aufgrund dessen sind nichtpeptidische Mimetika attraktive Ziele für die

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36

Milch, Gunther [Verfasser]. "Diastereoselektive Synthese N-geschützter 6-Amino-3-azabicyclo[3.1.0]hexane / vorgelegt von Gunther Milch." 2002. http://d-nb.info/96474631X/34.

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37

Ding, Mei-Fang, and 丁美芳. "Synthesis, structure and reactivity of metal carbonyl complex of 7-Azabicyclo[2.2.1]heptadiene derivatives." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/11592739984145938778.

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黃俊傑. "= Syntheses of 7-azabicyclo [2. 2. 1] heptadiene derivatives and their reactions with iron carbonyls." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/00695320433791731798.

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39

Atmuri, Nagavenkata. "Azabicycloalkanone synthesis by transannular cyclization." Thèse, 2014. http://hdl.handle.net/1866/12518.

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Une stratégie de synthèse efficace de différents composés de type azabicyclo[X.Y.0]alkanone fonctionnalisés a été développée. La stratégie synthétique implique la préparation de dipeptides par couplage avec des motifs vinyl-, allyl-, homoallyl- et homohomoallylglycine suivi d’une réaction de fermeture de cycle par métathèse permettant d’obtenir des lactames macrocycliques de 8, 9 et 10 membres, qui subissent une iodolactamisation transannulaire menant à l’obtention de mimes peptidiques bicycliques portant un groupement iode. Des couplages croisés catalysés par des métaux de transition ont

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40

Röper, Stefanie [Verfasser]. "Studien zur diastereoselektiven Funktionalisierung der Cinchona-Alkaloide und Synthese enantiomerenreiner, funktionalisierter 1-Azabicyclo[3.2.2]nonane / von Stefanie Röper." 2001. http://d-nb.info/966590236/34.

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41

Kühl, Jochen Eduard Wilhelm [Verfasser]. "Synthese und Verwendung chiraler Sulfoximinauxiliare bei der Darstellung von Azabicyclo[3.3.0]octan-Peptidmimetika / vorgelegt von Jochen Eduard Wilhelm Kühl." 2008. http://d-nb.info/987346520/34.

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42

wang, sing-yi, and 王馨儀. "Preparation of 1-Cyano-3-azabicyclo[3.1.0]hexanesby Thermal Decomposition of 1-Cyano-2,3,7-triazabicyclo[3.3.0]oct-2-enes." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/96965169621169645353.

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碩士<br>中原大學<br>化學研究所<br>94<br>Many derivatives of 3-azabicyclo[3.1.0]hexane are reported to be biological active and useful as pharmaceuticals , By Michael addition or nucleophilic substitution, a series of 1-Cyano-2,3,7-triazabicyclo[3.3.0]oct-2-enes derivatives can be prepared. Thermolysis of these 1-Cyano-2,3,7-triazabicyclo[3.3.0]oct-2-ene derivatives , give 3-azabicyclo[3.1.0]hexane and as the major product and 4,5-dihydropyrrole or 3-cyano-4-methyl pyrrole as the minor product. This method, which can successful synthesize many derivative of 3-azabicyclo[3.1.0]hexane with few steps an

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Lu, Li-Hui, and 盧麗慧. "Preparation of 3-Azabicyclo[3.1.0]hexanes and 3,4-Disubstituted pyrroles by Thermal Decomposition of 2,3,7-triazabicyclo[3.3.0]oct-2-enes." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/84903278920459151403.

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博士<br>中原大學<br>化學研究所<br>96<br>A new processes with facile preparation and high production yield for preparing derivatives of 3-azabicyclo[3.1.0]hexane and 2,5-dihydropyrrole are proposed in this research. The 1-position of 2,3,7-tri-azabicyclo[3.3.0]oct-2-ene derivatives can be substituted by COOR or CN and 7-position can be substituted by Michael addition reaction or nucleophilic substitu- tion reaction with different functional groups, and a series of 2,3,7-triazabicyclo[3.3.0]oct-2- ene derivatives(1-11) will be prepared. A series of derivatives of 3-azabicyclo[3.1.0]hexane (1A-11A) and 2,5

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Neipp, Christopher Ernest. "I. The synthesis of homoallylic amines via a 1,2-metalate rearrangement; II. The synthesis of bridged azabicyclic structures via ring-closing olefin metathesis." 2003. http://wwwlib.umi.com/cr/utexas/fullcit?p3116130.

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Miller, Kenneth Aaron 1979. "(Rh(CO)₂Cl)₂-catalyzed allylic substitution reactions and domino sequences and application of the Pauson-Khand reaction to the synthesis of azabicyclic structures: total synthesis of (-)-alstonerine." Thesis, 2007. http://hdl.handle.net/2152/3495.

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Examination of the scope of the [Rh(CO)₂Cl]₂-catalyzed allylic substitution reaction as well as the development of a domino [Rh(CO)₂Cl]₂-catalyzed allylic alkylation/Pauson Khand reaction is described. A number of experiments were carried out in order to explore the novel regioselectivity in the [Rh(CO)₂Cl]₂-catalyzed allylic substitution reaction, and the [Rh(CO)₂Cl]₂-catalyzed allylic substitution reaction was found to give products resulting from attack of the nucleophile on the carbon bearing the leaving group in a highly regioselective fashion in most cases. Examination of allylic carb

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Franz, Martin Heiko [Verfasser]. "Diastereoselektive Synthesen funktionalisierter 1-Azabicyclo[3.2.2]nonane : mechanistische Konzepte zur zweiten Cinchona-Umlagerung und Homologisierung an C9 der β-Aminoalkohole Quincorin und Quincoridin / von Martin Heiko Franz". 2003. http://d-nb.info/969347448/34.

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Chang, Yi-Mei, and 張依湄. "Lewis acid-Promoted Intramolecular Cyclization Reaction of Six-Member Ring 4-Ene- and 1-Yne-Ynamides： Synthesis of 6-Azabicyclo[3.2.1]octanes, Spiro[3.5]nonanes, and Isoquinolines." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/y4x2du.

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碩士<br>國立臺灣師範大學<br>化學系<br>105<br>Abstract This dissertation covered Lewis acid-promoted intramolecular cyclization reactions of six-membered ring 4-ene- and 1-yne-ynamides afforded 6-azabicyclo[3.2.1]octane, spiro[3.5]nonane, and isoquinoline derivatives. （1） The aluminum(III) chloride-promoted cyclization/chlorination of six-membered ring 4-(N-ethynylamino)cyclohexene enabled a straight forward approach to the 6-azabicyclo[3.2.1]octane. Acid treatment of the resultant chlorinated arylideneazabicyclooctanes furnished 3-alkanoyl-4-chlorocyclohex anamines in excellent yields and high stereosel

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Tebben, Gerd-Dieter [Verfasser]. "Intramolekulare Titan-vermittelte Aminocyclopropanierung als Zugang zu N-Benzyl-4-alkyl-2-azabicyclo[3.1.0]hexanen : Synthese von tri- und tetrasubstituierten Alkenen durch Palladium-katalysierte Kreuzkupplung von Alkin-Titan-Komplexen / vorgelegt von Gerd-Dieter Tebben." 2004. http://d-nb.info/973961708/34.

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Atmuri, Nagavenkata. "Design, synthesis and biomedical applications of Azabicycloalkanone Amino Acid Peptidomimetics." Thèse, 2019. http://hdl.handle.net/1866/22629.

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