Academic literature on the topic 'Azaspiracidi'

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Journal articles on the topic "Azaspiracidi"

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Hamilton, Brett, Mónica Díaz Sierra, Mary Lehane, Ambrose Furey, and Kevin J. James. "The fragmentation pathways of azaspiracids elucidated using positive nanospray hybrid quadrupole time-of-flight (QqTOF) mass spectrometry." Spectroscopy 18, no. 2 (2004): 355–62. http://dx.doi.org/10.1155/2004/949018.

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The azaspiracids, AZA1, AZA2 and AZA3, are the predominant shellfish toxins responsible for the human toxic syndrome, azaspiracid poisoning. Collision induced dissociation (CID) mass spectra were generated for azaspiracids using nano-electrospray ionisation (ESI) with a hybrid quadrupole time-of-flight (QqTOF) mass spectrometer in positive mode. Six main backbone fragmentations of the polyether skeleton of azaspiracids were observed as well as multiple neutral losses of water molecules from the parent and product ions. The characteristic charge-remote fragmentation of the carbon skeleton of az
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Yang, Jiaping, Xinhao Li, Weiqin Sun, et al. "High Affinity Aptamers and Their Specificity for Azaspiracid-2 Using Capture-SELEX." Marine Drugs 23, no. 5 (2025): 183. https://doi.org/10.3390/md23050183.

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Azaspiracids are a type of polyether toxin. Currently, the existing detection methods for azaspiracids all have certain drawbacks. Aptamers offer a cost-effective and convenient approach for the detection of azaspiracids. By employing the Capture-SELEX (Systematic evolution of ligands by exponential enrichment) method to screen aptamers specific to azaspiracid-2, a high-affinity aptamer can be identified for toxin detection. The bin ding affinity of the toxin is verified using biolayer interferometry (BLI) technology. Additionally, computer simulations are utilized to explore the binding sites
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Kilcoyne, Jane, Adela Keogh, Ger Clancy, et al. "Improved Isolation Procedure for Azaspiracids from Shellfish, Structural Elucidation of Azaspiracid-6, and Stability Studies." Journal of Agricultural and Food Chemistry 60, no. 10 (2012): 2447–55. http://dx.doi.org/10.1021/jf2048788.

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Abal, Paula, M. Carmen Louzao, María Fraga, et al. "Absorption and Effect of Azaspiracid-1 Over the Human Intestinal Barrier." Cellular Physiology and Biochemistry 43, no. 1 (2017): 136–46. http://dx.doi.org/10.1159/000480331.

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Background: Azaspiracids (AZAs) are marine biotoxins produced by the dinoflagellates genera Azadinium and Amphidoma. These toxins cause azaspiracid poisoning (AZP), characterized by severe gastrointestinal illness in humans after the consumption of bivalve molluscs contaminated with AZAs. The main aim of the present study was to examine the consequences of human exposure to AZA1 by the study of absorption and effects of the toxin on Caco-2 cells, a reliable model of the human intestine. Methods: The ability of AZA1 to cross the human intestinal epithelium has been evaluated by the Caco-2 trans
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Trainer, Vera L., and Teri L. King. "SoundToxins: A Research and Monitoring Partnership for Harmful Phytoplankton in Washington State." Toxins 15, no. 3 (2023): 189. http://dx.doi.org/10.3390/toxins15030189.

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The more frequent occurrence of marine harmful algal blooms (HABs) and recent problems with newly-described toxins in Puget Sound have increased the risk for illness and have negatively impacted sustainable access to shellfish in Washington State. Marine toxins that affect safe shellfish harvest because of their impact on human health are the saxitoxins that cause paralytic shellfish poisoning (PSP), domoic acid that causes amnesic shellfish poisoning (ASP), diarrhetic shellfish toxins that cause diarrhetic shellfish poisoning (DSP) and the recent measurement of azaspiracids, known to cause az
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Kilcoyne, Jane, Pearse McCarron, Michael J. Twiner, et al. "Epimers of Azaspiracids: Isolation, Structural Elucidation, Relative LC-MS Response, andin VitroToxicity of 37-epi-Azaspiracid-1." Chemical Research in Toxicology 27, no. 4 (2014): 587–600. http://dx.doi.org/10.1021/tx400434b.

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Krock, Bernd, Urban Tillmann, Uwe John, and Allan D. Cembella. "Characterization of azaspiracids in plankton size-fractions and isolation of an azaspiracid-producing dinoflagellate from the North Sea." Harmful Algae 8, no. 2 (2009): 254–63. http://dx.doi.org/10.1016/j.hal.2008.06.003.

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OFUJI, Katsuya, Masayuki SATAKE, Terry MCMAHON, et al. "Structures of Azaspiracid Analogs, Azaspiracid-4 and Azaspiracid-5, Causative Toxins of Azaspiracid Poisoning in Europe." Bioscience, Biotechnology, and Biochemistry 65, no. 3 (2001): 740–42. http://dx.doi.org/10.1271/bbb.65.740.

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Zhao, Liye, Jiangbing Qiu, Jingrui Zhang, Aifeng Li, and Guixiang Wang. "Apoptosis and Oxidative Stress in Human Intestinal Epithelial Caco-2 Cells Caused by Marine Phycotoxin Azaspiracid-2." Toxins 16, no. 9 (2024): 381. http://dx.doi.org/10.3390/toxins16090381.

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When humans consume seafood contaminated by lipophilic polyether phycotoxins, such as azaspiracids (AZAs), the toxins are mainly leached and absorbed in the small intestine, potentially causing intestinal damage. In this study, human intestinal epithelial Caco-2 cells were used to investigate the adverse effects of azaspiracid-2 (AZA-2) on human intestinal epithelial cells. Cell viability, apoptosis, oxidative damage and mitochondrial ultrastructure were investigated, and ribonucleic acid sequence (RNA-seq) analysis was applied to explore the potential mechanisms of AZA-2 toxicity to Caco-2 ce
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Rossi, Rachele, Carmela Dell’Aversano, Bernd Krock, et al. "Mediterranean Azadinium dexteroporum (Dinophyceae) produces six novel azaspiracids and azaspiracid-35: a structural study by a multi-platform mass spectrometry approach." Analytical and Bioanalytical Chemistry 409, no. 4 (2016): 1121–34. http://dx.doi.org/10.1007/s00216-016-0037-4.

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Dissertations / Theses on the topic "Azaspiracidi"

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D'ORLANDO, ELISABETTA. "TOSSICITA’ IN VIVO ED IN VITRO DI AZASPIRACIDI." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908010.

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Gli azaspiracidi (AZAs) sono delle tossine marine lipofile, comprendenti più di 30 analoghi prodotti dal dinoflagellato Azadinium spinosum o derivanti dal metabolismo di alcuni AZAs nei molluschi. Essi possono contaminare i molluschi eduli e provocare un’intossicazione alimentare (Azaspiracid Shellfish Poisoning, AZP), caratterizzata da nausea, vomito, diarrea e crampi allo stomaco. Attualmente, solo tre AZAs (AZA1, 2 e 3) sono regolamentati nell’Unione Europea ed il massimo livello ammissibile nei molluschi è pari a 160 µg di equivalenti di AZA1/kg di parti edibili. La concentrazione totale d
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Kenton, Nathaniel T. "Total Synthesis of Azaspiracid-3, C20-epi-Azaspiracid-3, and Structural Definition of the Azaspiracids." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523545452232749.

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Okumu, Antony A. "Toward Total Synthesis of Azaspiracid-3 and Azaspiracid-34." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461282755.

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Yue, Ding. "Towards the total synthesis of Azaspiracid-3." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1284488476.

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Zhou, Feng. "Synthesis of The ABCD Domain of The Azaspiracids." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1267992158.

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Mzoughet, Kouassi ahou Judith Elisabeth Patricia. "Physiochemical and proteomic studies on azaspiracid contaminated mussels." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517086.

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Zhang, Zhigao. "Efforts towards the Total Synthesis of Azaspiracid-3." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366108671.

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Chen, Yong. "Synthetic Studies on Total Synthesis of Azaspiracid-3." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385895424.

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Adu-Ampratwum, Daniel Dr. "Synthesis of the ABCD- and EFGHI-Domains of Azaspiracid-3." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461310628.

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Jauffrais, Thierry. "Ecophysiologie des dinoflagellés du genre Azadinium, production toxinique et transfert trophique vers les mollusques bivalves." Nantes, 2012. http://archive.bu.univ-nantes.fr/pollux/show.action?id=040c4b77-66f9-4f28-b05d-261282d9575f.

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Cette thèse a été menée pour développer une méthode d’analyse et de production des azaspiracides (AZA) à partir de cultures d’A. Spinosum. Elle a aussi eu pour objectif l’étude des facteurs environnementaux et nutritionnels influant sur la croissance et la production toxinique d’A. Spinosum. La mise en évidence du lien entre cet organisme et l'accumulation d’AZA dans les moules, ainsi que la clarification des processus d’accumulation, de détoxification et de biotransformation des AZA dans les moules a par ailleurs été réalisée. Les travaux réalisés sur l’analyse des AZA ont permis de définir u
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Book chapters on the topic "Azaspiracidi"

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Hess, Philipp, Michael J. Twiner, Jane Kilcoyne, and Silvio Sosa. "Azaspiracid Toxins: Toxicological Profile." In Marine and Freshwater Toxins. Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-007-6419-4_20.

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Hess, Philipp, Michael J. Twiner, Jane Kilcoyne, and Silvio Sosa. "Azaspiracid Toxins: Toxicological Profile." In Marine and Freshwater Toxins. Springer Netherlands, 2015. http://dx.doi.org/10.1007/978-94-007-6650-1_20-1.

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Jauffrais, T., V. Séchet, P. Truquet, Zouher Amzil, C. Herrenknecht, and P. Hess. "Effect of Dilution Rate on Azadinium spinosum and Azaspiracid (AZA) Production in Pilot Scale Photobioreactors for the Harvest of AZA1 and -2." In Molluscan Shellfish Safety. Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6588-7_17.

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Garcia Fernández, Javier, Daniel O’Driscoll, Ambrose Furey, and Kevin James. "Azaspiracids." In Seafood and Freshwater Toxins. CRC Press, 2008. http://dx.doi.org/10.1201/9781420007541.ch35.

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Ito, Emiko. "Toxicology of Azaspiracid-1." In Seafood and Freshwater Toxins. CRC Press, 2008. http://dx.doi.org/10.1201/9781420007541.ch36.

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"Azaspiracids: Chemistry, Bioconversion, and Determination." In Seafood and Freshwater Toxins. CRC Press, 2008. http://dx.doi.org/10.1201/9781420007541-57.

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Hess, Philipp, Pearse McCarron, Bernd Krock, Jane Kilcoyne, and Christopher O. Miles. "Azaspiracids: Chemistry, Biosynthesis, Metabolism, and Detection." In Seafood and Freshwater Toxins. CRC Press, 2014. http://dx.doi.org/10.1201/b16662-27.

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Twiner, Michael J., Philipp Hess, and Gregory J. Doucette. "Azaspiracids: Toxicology, Pharmacology, and Risk Assessment." In Seafood and Freshwater Toxins. CRC Press, 2014. http://dx.doi.org/10.1201/b16662-28.

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"Pharmacology and Epidemiological Impact of Azaspiracids." In Seafood and Freshwater Toxins. CRC Press, 2008. http://dx.doi.org/10.1201/9781420007541-56.

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Ryan, Gavin, Kevin Cunningham, and Michael Ryan. "Pharmacology and Epidemiological Impact of Azaspiracids." In Seafood and Freshwater Toxins. CRC Press, 2008. http://dx.doi.org/10.1201/9781420007541.pt11.

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Conference papers on the topic "Azaspiracidi"

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Vale, Carmen, Andrea Boente-Juncal, Sandra Raposo-García, et al. "Activation of anion channels in human cells after long term exposure to the marine toxin azaspiracid." In 1st International Electronic Conference on Toxins. MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09114.

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