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Journal articles on the topic 'Azetidine-2-one'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Takagi, Hiroshi, Mika Shichiri, Miho Takemura, Miho Mohri та Shigeru Nakamori. "Saccharomyces cerevisiae Σ1278b Has Novel Genes of the N-Acetyltransferase Gene Superfamily Required for l-Proline Analogue Resistance". Journal of Bacteriology 182, № 15 (2000): 4249–56. http://dx.doi.org/10.1128/jb.182.15.4249-4256.2000.

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ABSTRACT We discovered on the chromosome of Saccharomyces cerevisiae Σ1278b novel genes involved in l-proline analogue l-azetidine-2-carboxylic acid resistance which are not present in the standard laboratory strains. The 5.4 kb-DNA fragment was cloned from the genomic library of thel-azetidine-2-carboxylic acid-resistant mutant derived from a cross between S. cerevisiae strains S288C and Σ1278b. The nucleotide sequence of a 4.5-kb segment exhibited no identity with the sequence in the genome project involving strain S288C. Deletion analysis indicated that one open reading frame encoding a pre

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2

Çelik, Ísmail, Mehmet Akkurt, Aliasghar Jarrahpour, Edris Ebrahimi, and Orhan Büyükgüngör. "4-(9-Anthryl)-1-phenylspiro[azetidine-3,9′-xanthen]-2-one." Acta Crystallographica Section E Structure Reports Online 65, no. 3 (2009): o501—o502. http://dx.doi.org/10.1107/s1600536809004255.

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3

Atioğlu, Zeliha, Mehmet Akkurt, Aliasghar Jarrahpour, Roghayeh Heiran, and Namık Özdemir. "1-(Morpholin-4-yl)-4-(2-nitrophenyl)spiro[azetidine-3,9′-xanthen]-2-one." Acta Crystallographica Section E Structure Reports Online 70, no. 7 (2014): o772—o773. http://dx.doi.org/10.1107/s1600536814013464.

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In the title compound, C22H21N3O5, the β-lactam (azetidin-2-one) ring is nearly planar [maximum deviation = 0.010 (1) Å] and makes dihedral angles of 69.22 (5), 55.32 (5) and 89.42 (4)° with the least-squares planes formed by the four C atoms of the morpholine ring, which adopts a chair conformation, the benzene ring and the xanthene ring system, respectively. In the crystal, C—H...O hydrogen-bond contacts connect neighbouring molecules into infinite zigzag chains running parallel to thebaxis.

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4

Abdullah, Shaima H., Bushra A. Khairallah, and Khalid A. Al-Badrany. "Preparation and characterization of some azetidine-2-one derivatives derived from benzothiazole-2-ol and evaluation of their biological activity." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 37. https://doi.org/10.59467/ijhc.2025.35.37.

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This study involves the use of hydrazones derived from 2-hydroxybenzothiazole as nucleophiles to prepare several heterocyclic azetidine derivatives by reacting the prepared hydrazone with chloroacetyl chloride. Dioxane was used as a solvent, and triethylamine was used as a catalyst. In addition to determining the melting point, the structures of the prepared compounds were confirmed by physical and spectroscopic methods, infrared, proton, and carbon nuclear magnetic resonance (1H and 13C-NMR) spectroscopy, and thin layer chromatography to track the reaction progress. The biological viability w

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5

Ahmed, Aya, and Monther Faisal. "In-silico molecular docking, ADME study, and molecular dynamic simulation of new azetidin-2-one derivatives with antiproliferative activity." Turkish Computational and Theoretical Chemistry 9, no. 1 (2024): 29–40. http://dx.doi.org/10.33435/tcandtc.1498365.

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Over the past two decades, protein kinase has been a heavily studied target in the development of new anti-proliferative medications. Heterocyclic systems have been identified as the preferred scaffold because of their wide range of biological properties. In this research, the objective was to design and develop fifteen novel azetidin-2-one derivatives and assess their cytotoxic potential as inhibitors of the epidermal growth factor receptor, which is considered one of the key factors influencing cell growth and proliferation. The crystal structure of inactive EGFR tyrosine kinase domain ligan

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6

Sandip, Sen, S. Easwari T., and De Biplab. "Antimicrobial and anti-nociceptive profile of some 4-(3-methyl-1-phenyl-1Hpyrazol-4-yl)-1-phenylazetidin-2-o." Journal of Indian Chemical Society Vol. 91, Nov 2014 (2014): 2089–99. https://doi.org/10.5281/zenodo.5741383.

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IIMT College of Medical Sciences, O. Pocket, Ganga Nagar, Meerut-250 001, Uttar Pradesh, India Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala-799 006, Tripura, India <em>E-mail </em>: biplab_32@yahoo.co.in <em>Manuscript received online 04 March 2014, revised 28 April 2014, accepted 16 June 2014</em> A new series of 4-(3-methyl-1-phenyl-1<em>H</em>-pyrazol-4-yl)-1-phenylazetidin-2-ones (7a-j) were prepared by intermolecular cyclization of Schiff bases (6a-j) and mono chloro acetyl chloride in the presence of base catalyst triethyl amine. The biological evalua

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7

Ramachandran, S., N. Vimeshya, K. Yogeshwaran, Binoy Varghese Cheriyan, and M. Vijey Aanandhi. "Molecular docking studies, synthesis, characterisation, and evaluation of azetidine-2-one derivative." RESEARCH JOURNAL OF PHARMACY AND TECHNOLOGY 14, no. 3 (2021): 1571–75. http://dx.doi.org/10.5958/0974-360x.2021.00277.8.

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8

Çelik, Ísmail, Mehmet Akkurt, Aliasghar Jarrahpour, Edris Ebrahimi, and Orhan Büyükgüngör. "4-(9-Anthryl)-1-(3-bromophenyl)spiro[azetidine-3,9′-xanthen]-2-one." Acta Crystallographica Section E Structure Reports Online 65, no. 10 (2009): o2522—o2523. http://dx.doi.org/10.1107/s1600536809037830.

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9

Baktır, Zeliha, Mehmet Akkurt, Aliasghar Jarrahpour, Edris Ebrahimi, and Orhan Büyükgüngör. "4-(9-Anthryl)-1-(2,4-dimethoxyphenyl)spiro[azetidine-3,9′-xanthen]-2-one." Acta Crystallographica Section E Structure Reports Online 65, no. 7 (2009): o1623—o1624. http://dx.doi.org/10.1107/s1600536809022739.

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10

Çelik, İsmail, Mehmet Akkurt, Aliasgar Jarrahpour, E. Ebrahimi, and Orhan Büyükgüngör. "Molecular structure of 4-(9-anthryl)-1-phenylspiro[azetidine-3,90-xanthen]-2-one." Acta Crystallographica Section A Foundations of Crystallography 65, a1 (2009): s234—s235. http://dx.doi.org/10.1107/s0108767309095166.

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11

AlKhayat, Sedra, and salim mohamed. "Synthesis and Characterization of Azetidine-2-One and Pyridazine Derivatives from Substituted Benzimidazole." Rafidain Journal of Science 34, no. 1 (2025): 43–51. https://doi.org/10.33899/rjs.2025.186494.

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12

Drăgan, Maria, Cătălina Daniela Stan, Andreea Teodora Iacob, et al. "Biological Evaluation of Azetidine-2-One Derivatives of Ferulic Acid as Promising Anti-Inflammatory Agents." Processes 8, no. 11 (2020): 1401. http://dx.doi.org/10.3390/pr8111401.

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The purpose of this study was to evaluate the in vivo biological potential of new azetidine-2-one derivatives of ferulic acid (6a–f). First, the in vivo acute toxicity of azetidine-2-one derivatives of ferulic acid on Swiss white mice was investigated and, based on the obtained results, it can be stated that the studied derivatives belong to compounds with moderate toxicity. The in vivo anti-inflammatory potential of these derivatives was determined in a model of acute inflammation induced by carrageenan in rats and in a chronic inflammation model induced in rats using the granuloma test. In t

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13

Rani, V. Esther, and P. Raveendra Reddy. "Synthesis and Antimicrobial Activity of New Pyridine Containing Substituted Phenyl Azetidine-2-One Derivatives." Open Journal of Medicinal Chemistry 08, no. 02 (2018): 22–29. http://dx.doi.org/10.4236/ojmc.2018.82003.

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14

Noolvi, Malleshappa, Suresh Agrawal, Harun Patel, Aravind Badiger, Monika Gaba, and Azit Zambre. "Synthesis, antimicrobial and cytotoxic activity of novel azetidine-2-one derivatives of 1H-benzimidazole." Arabian Journal of Chemistry 7, no. 2 (2014): 219–26. http://dx.doi.org/10.1016/j.arabjc.2011.02.011.

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15

Gudelis, Emilis, Sonata Krikštolaitytė, Monika Stančiauskaitė, et al. "Synthesis of New Azetidine and Oxetane Amino Acid Derivatives through Aza-Michael Addition of NH-Heterocycles with Methyl 2-(Azetidin- or Oxetan-3-Ylidene)Acetates." Molecules 28, no. 3 (2023): 1091. http://dx.doi.org/10.3390/molecules28031091.

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In this paper, a simple and efficient synthetic route for the preparation of new heterocyclic amino acid derivatives containing azetidine and oxetane rings was described. The starting (N-Boc-azetidin-3-ylidene)acetate was obtained from (N-Boc)azetidin-3-one by the DBU-catalysed Horner–Wadsworth–Emmons reaction, followed by aza-Michael addition with NH-heterocycles to yield the target functionalised 3-substituted 3-(acetoxymethyl)azetidines. Methyl 2-(oxetan-3-ylidene)acetate was obtained in a similar manner, which was further treated with various (N-Boc-cycloaminyl)amines to yield the target 3

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16

Muhammed, Muhammed. "Synthesis, Characterization of Substituted 1,3-Oxazepine, Thiazolidine-4-one and Azetidine-2-one Using Benzimidazole as a Synthon." Rafidain Journal of Science 32, no. 1 (2023): 110–20. http://dx.doi.org/10.33899/rjs.2023.177293.

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17

Çelik, Ísmail, Mehmet Akkurt, Aliasghar Jarrahpour, Roghayeh Heiran, and Namık Özdemir. "1-[3-(Morpholin-4-yl)propyl]-4-(3-nitrophenyl)spiro[azetidine-3,9′-xanthen]-2-one." Acta Crystallographica Section E Structure Reports Online 70, no. 3 (2014): o369—o370. http://dx.doi.org/10.1107/s160053681400419x.

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The β-lactam (azetidin-2-one) ring of the title compound, C28H27N3O5, is nearly planar [maximum deviation = 0.010 (1) Å] and makes dihedral angles of 75.77 (5), 52.78 (9) and 88.72 (5)°, respectively, with the benzene ring, the least-squares plane formed by the four C atoms of the morpholine ring, which adopts a chair conformation, and the xanthene ring system. In the crystal, C—H...O hydrogen-bond contacts connect neighbouring molecules into infinite zigzag chains running parallel to thebaxis.

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18

Gandhi, Divyani, Ayushi Sethiya, Dinesh Kr Agarwal, Prakash Prajapat, and Shikha Agarwal. "Design, Synthesis and Antimicrobial Study of Novel 1-(1,3-benzothiazol-2- yl)-3-chloro-4H-spiro[azetidine-2,3'-indole]-2',4(1'H)-diones Through Ketene– imine Cycloaddition Reaction." Letters in Organic Chemistry 17, no. 2 (2020): 141–48. http://dx.doi.org/10.2174/1570178616666190705153224.

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: The present study deals with the synthesis of novel 1-(1,3-benzothiazol-2-yl)-3-chloro-4Hspiro[ azetidine-2,3'-indole]-2',4(1'H)-dione derivatives from the reaction of 3-(1,3-benzothiazol-2- ylimino)-1,3-dihydro-2H-indol-2-one derivatives with chloroacetyl chloride in the presence of triethylamine (TEA). The mechanism involved simple acid or base catalysed reaction through the formation of Schiff base followed by cyclisation via ketene–imine cycloaddition reaction. All synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR, and elemental analysis. The antimicrobial activities of

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19

Hanoon, H. D., H. A. Abd Al Hussain, and S. K. Abass. "Synthesis and characterization of azetidin-2-one and 1,3-oxazepine derivatives using Schiff bases derived from 1,1’-biphenyl-4,4’-diamine." Journal of Physics: Conference Series 2063, no. 1 (2021): 012010. http://dx.doi.org/10.1088/1742-6596/2063/1/012010.

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Abstract The present study included the synthesis of two series of heterocyclic compounds, azetidin-2-one and 1,3-oxazepine derivatives. All synthesized compounds were characterized using FT-IR and 1H NMR spectra. The study was divided into two parts. The first synthesis Schiff bases derivatives (1-4) via the condensation reaction of 1,1′-biphenyl-4,4′-diamine (A) with benzaldehyde derivatives (2,5-dimethoxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, furan-2-carbaldehyde and 3-hydroxybenzaldehyde). The second synthesis azetidine-2-one derivatives (5-8) from the reaction of Schiff bases with

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20

Peters, K., E. M. Peters, T. Franz, and V. Jäger. "Crystal structure of (3S,4R,1'R)-1-benzyl-3-benzyloxy-4-(1'-benzyloxy-2'- hydroxyethyI)-azetidine-2-one, C26H27NO4." Zeitschrift für Kristallographie - New Crystal Structures 212, no. 1 (1997): 421–22. http://dx.doi.org/10.1524/ncrs.1997.212.1.421.

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21

Mandal, Milan Kumar, Swagatika Ghosh, Hans Raj Bhat, Lieve Naesens, and Udaya Pratap Singh. "Synthesis and biological evaluation of substituted phenyl azetidine-2-one sulphonyl derivatives as potential antimicrobial and antiviral agents." Bioorganic Chemistry 104 (November 2020): 104320. http://dx.doi.org/10.1016/j.bioorg.2020.104320.

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22

Salgado, Mateo M., Alejandro Manchado, Carlos T. Nieto, David Díez, and Narciso M. Garrido. "Synthesis and Modeling of Ezetimibe Analogues." Molecules 26, no. 11 (2021): 3107. http://dx.doi.org/10.3390/molecules26113107.

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Ezetimibe is a well-known drug that lowers blood cholesterol levels by reducing its absorption in the small intestine when joining to Niemann-Pick C1-like protein (NPC1L1). A ligand-based study on ezetimibe analogues is reported, together with one-hit synthesis, highlighted in the study. A convenient asymmetric synthesis of (2S,3S)-N-α-(R)-methylbenzyl-3-methoxycarbonylethyl-4-methoxyphenyl β-lactam is described starting from Baylis–Hillman adducts. The route involves a domino process: allylic acetate rearrangement, stereoselective Ireland–Claisen rearrangement and asymmetric Michael addition,

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23

Kuroda, Kohei, Kohji Ishihara, and Noriyoshi Masuoka. "Characterization of Nicotianamine Isolated from Soybeans." Journal of Food Research 2, no. 2 (2013): 49. http://dx.doi.org/10.5539/jfr.v2n2p49.

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<p>Angiotensin ?-converting enzyme (ACE) [EC 3.4.15.1] plays one of important roles to control the arterial blood pressure. Inhibitory activity of the enzyme has been reportedly detected in plant foods.</p> <p>We examined the activity in plant foods and isolated an ACE inhibitor in soybeans. The structure was identified as nicotianamine, <em>N</em>-[<em>N</em>-(3-amino-3carboxypropyl)-3-amino-3-carboxypropyl]-azetidine-2-carboxylic acid. The contents in several soybean foods were estimated using an amino acid analyzer. The chelation capacity of nicotia

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24

ACHMATOWICZ, O., I. MALINOWSKA, A. WISNIEWSKA, Z. GALDECKI, and A. FRUZINSKI. "ChemInform Abstract: Enantioselective Synthesis of (S)-(-)-3-Amino-5-(morpholinomethyl)-1,3- oxazolidin-2-one. An Intramolecular Competition for Oxirane versus Azetidine Ring Formation." ChemInform 27, no. 46 (2010): no. http://dx.doi.org/10.1002/chin.199646186.

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25

Murakami, Naoyuki, Atsushi Kotaka, Shota Isogai та ін. "Effects of a novel variant of the yeast γ-glutamyl kinase Pro1 on its enzymatic activity and sake brewing". Journal of Industrial Microbiology & Biotechnology 47, № 9-10 (2020): 715–23. http://dx.doi.org/10.1007/s10295-020-02297-1.

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Abstract Sake is a traditional Japanese alcoholic beverage brewed with the yeast Saccharomyces cerevisiae. Sake taste is affected by sugars, organic acids, and amino acids. We previously isolated mutants resistant to the proline analogue azetidine-2-carboxylate derived from a diploid sake yeast strain. Some of the mutants produced a greater amount of proline in the brewed sake. One of them (strain K-9-AZC) carried a novel mutation in the PRO1 gene encoding the Gln79His variant of the γ-glutamyl kinase Pro1, a key enzyme in proline biosynthesis in S. cerevisiae. This mutation resulted in extrem

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26

Jang, Jinho, Linlin Zhang, Hye Jung Kim, Sung Ryoung Lee, and Sung Hoon Kim. "Silver(I)-catalyzed hydroamination of (3S, 4R)-4-acetoxy-3-[(R)-1-tert-butyldimethylsiloxy)ethyl]azetidine-2-one derivatives for the synthesis of carbapenem skeleton." Tetrahedron Letters 94 (March 2022): 153712. http://dx.doi.org/10.1016/j.tetlet.2022.153712.

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27

de Jong, W. W., W. A. Hoekman, J. W. Mulders, and H. Bloemendal. "Heat shock response of the rat lens." Journal of Cell Biology 102, no. 1 (1986): 104–11. http://dx.doi.org/10.1083/jcb.102.1.104.

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The sequence relationship between the small heat shock proteins and the eye lens protein alpha-crystallin (Ingolia, T. D., and E. E. Craig, 1982, Proc. Natl. Acad. Sci. USA, 79: 2360-2364) prompted us to subject rat lenses in organ culture to heat shock and other forms of stress. The effects on protein synthesis were followed by labeling with [35S]methionine and analysis by one- and two-dimensional gel electrophoresis and fluorography. Heat shock gave a pronounced induction of a protein that could be characterized as the stress protein SP71. This protein probably corresponds to the major mamma

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28

Ivanenkov, Yan A., Renat S. Yamidanov, Ilya A. Osterman, et al. "Identification of N-Substituted Triazolo-azetidines as Novel Antibacterials using pDualrep2 HTS Platform." Combinatorial Chemistry & High Throughput Screening 22, no. 5 (2019): 346–54. http://dx.doi.org/10.2174/1386207322666190412165316.

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Aim and Objective: Antibiotic resistance is a serious constraint to the development of new effective antibacterials. Therefore, the discovery of the new antibacterials remains one of the main challenges in modern medicinal chemistry. This study was undertaken to identify novel molecules with antibacterial activity. Materials and Methods: Using our unique double-reporter system, in-house large-scale HTS campaign was conducted for the identification of antibacterial potency of small-molecule compounds. The construction allows us to visually assess the underlying mechanism of action. After the in

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Chen, Yue, Ning Zhai, Peibin Yue, et al. "Abstract 663: Irreversible covalent azetidine-based small molecule inhibitors of Stat3 activity block growth of human pancreatic tumors." Cancer Research 84, no. 6_Supplement (2024): 663. http://dx.doi.org/10.1158/1538-7445.am2024-663.

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Abstract The incidence and death rates for pancreatic adenocarcinoma in the US have been increasing by about 1% per year and the death rate has increased by approximately 0.2% yearly. The five-year survival rate has remained below 10% for many years. With surgery, radiation, and chemotherapy being the main treatment options to extend survival or for symptom relief, there is an urgent unmet need for effective new treatment options. Signal Transducer and Activator of Transcription (Stat) 3, one of the Stat family members, is aberrantly activated in human pancreatic and many other cancers. Aberra

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30

Tamura, Y., N. Tsuboi, N. Sato, and K. Kikuchi. "70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity." Journal of Immunology 151, no. 10 (1993): 5516–24. http://dx.doi.org/10.4049/jimmunol.151.10.5516.

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Abstract We previously investigated a novel heat-inducible transformation-associated cell surface Ag that is expressed on the activated H-ras oncogene-transformed rat fibrosarcoma W31, but not its parental nontransformed fibroblast WFB. This Ag was detected by mAb 067. Herein, we characterized the molecular nature of the Ag by using anti-heat shock protein (HSP) mAb. The accumulated data indicated that the cell surface expression of Ag was clearly enhanced by several stressors, such as TNF, L-azetidine-2-carboxylic acid, and sodium arsenite. The immunoprecipitate made with mAb 067 and W31 cell

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Alcaide, Benito, Pedro Almendros та Cristina Aragoncillo. "A Novel One-Step Approach for the Preparation of α-Amino Acids, α-Amino Amides, and Dipeptides from Azetidine-2,3-diones". Chemistry - A European Journal 8, № 16 (2002): 3646. http://dx.doi.org/10.1002/1521-3765(20020816)8:16<3646::aid-chem3646>3.0.co;2-m.

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S., Ramachandran, Binoy Varghese Cheriyan, and M. Vijey Aanandhi. "Activities of Thiazolidine-4-one and Azetidine-2-one Derivatives- A Review." Research Journal of Pharmacy and Technology, August 6, 2021, 4513–16. http://dx.doi.org/10.52711/0974-360x.2021.00785.

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Thiazolidine-4-ones containing thiazole moiety have been synthesized by condensing 6-amino Coumarin, Isatin and Primary amines, and aromatic aldehydes. Azetidine derivates were synthesized followed by cyclizations by C-N bond formation and by the C-C bond formation, the amine-catalyzed cycloaddition of allenoates and imines, photocycloadditions of imines and alkenes, ring contraction and expansion rearrangements, and reduction of azetidine-2-ones (β-lactams). Thiazolidine-4-ones has been considered as a magic moiety because it posses almost all types of biological activities such as Antifungal

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"VARIOUS ACTIVITIES OF AZETIDINE-2-ONE DERIVATIVES - A REVIEW." International Journal of Biology, Pharmacy and Allied Sciences 11, no. 8 (2022). http://dx.doi.org/10.31032/ijbpas/2022/11.8.6321.

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34

Ramachandran, S., S. Dheepika, M. Deepak, M. Duraiseelan, B. S. Chandru, and M. Vijey Aanandhi. "Synthesis, Characterisation and Evaluation of Azetidine-2-One Derivative." Journal of Pharmaceutical Research International, March 24, 2022, 41–44. http://dx.doi.org/10.9734/jpri/2022/v34i27a35992.

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Antibacterial, antifungal, anticancer, antitubercular, anti-HIV, analgesic, anti-inflammatory, and ulcerogenic activities have all been documented for azetidinone derivatives. The reaction of Schiff base((Z)-N (4-dimethylamino)benzylidene)pyrimidine-2-amine) with chloroacetyl chloride yielded a novel chemical called Azetdine-2-one derivative. Fourier Transform Infrared Spectroscopy and Proton Nuclear Magnetic Resonance Spectroscopy were used to confirm the chemical structures of the produced substances. The antimicrobial activity shows that the compound showed mild Antibacterial activity

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35

Liu, Teng, Chao Huang, Feixiang Cheng, et al. "Organocatalyzed [2+2] Cycloaddition Reactions between Quinone Imine Ketals and Allenoates." Synthesis, September 24, 2020. http://dx.doi.org/10.1055/s-0040-1707292.

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AbstractA new cycloaddition reaction of quinone imine ketals (QIKs), which could be utilized to the construction of functionalized azaspirocyclics under mild conditions, is described. This transformation involved a [2+2] cycloaddition reaction between QIKs and allenoates catalyzed by DABCO, and then treatment with 1 N HCl in one-pot. The strategy could provide a practical route to access azetidine-fused spirohexadienones in good to excellent yields and with high E-selectivity.

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Ayed, Duaa Jassim, and Marwan Mohammed Farhan. "Synthesis and characterization of binary compounds of the novel Azetidin-2-one ring and comparison of its biological activity." International journal of health sciences, October 2, 2022, 4437–52. http://dx.doi.org/10.53730/ijhs.v6ns8.13206.

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New organic compounds were prepared with two groups of azetidine-2-one, respectively.And that through the first two steps: New compounds were prepared with two groups of azomethine, by reacting benzaldehyde derivatives with primary amino compounds with di-amino groups. The result was diagnosed by following TLC, M.P, FT.IR.The second step: The azomethine compounds prepared in the previous step reacted with acetic acid dichloride with different molar numbers (1:2) and were diagnosed spectroscopically and physically by (TLC, M.P, FT.IR,H1NMR,C13.NMR.C.H.N.X.) to confirm the correctness of the str

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Patel, Thakor, Bhavik Hemant Kumar Panchal, and Shanta Raj Lakshmi. "Some Novel Series of 3-Alkylidene 3-Phenylthio-3-Chloro Azetidine -2-One Were Synthesized by The Staudinger Ketene-Imine Cycloaddition and Evaluation of Their Biological Activity." South Eastern European Journal of Public Health, October 31, 2024, 1014–20. http://dx.doi.org/10.70135/seejph.vi.1940.

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Various series of 3-alkylidene 3-Phenylthio-3-Chloro azetidine -2-one(5) synthesized by reaction of 1- (4'-Methoxyphenyl)-3-chloro-3-phenylthio-4,4-diethoxycarbonylazetidin-2-one (4) with thionyl chloride taking MDC as solvent while synthesis of Compound 4 carried out the reaction between phenyl thio acetic acid and N-(4-Methoxyphenyl)-1,1-diethoxycarbonylimine (2) while compound second synthesized by staring material diethyl keto malonate and p-anisidine. these newly synthesized compound were evaluate using different analytical tools These compounds were also evaluated for their anti- inflamm

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Fadhil, Tamarah A., and Waleed Faraj AL-Hiti. "Synthesis, characterization of new 3-Chloro-Azetidine-2-One and 1, 3-thiazinan-4-one derivatives from di imines." International journal of health sciences, June 29, 2022, 5732–47. http://dx.doi.org/10.53730/ijhs.v6ns5.9950.

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The study Included synthesis of some new Derivatives of (benzylideneamino)-3-chloro-4-phenylazetidin-2-one and 3-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-2-phenyl-1,3-thiazinan-4-one by tow steps; The first include amino group of the di amino was condensed with different aromatic aldehydes in the presence of absolute ethanol to give new Schiff bases derivatives [1– 3] respectively. The second step , the resulting imines derivatives [1 – 3] were reacted with chloro acetyl chloride in presence of triethylamine in dry benzene by per cyclic reaction to give novel 3-(3-chloro-2-oxo-4-phenylazetidin-1

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39

Novák, Tamás T., Lorand Kiss, Gábor Turczel, et al. "Fluorinative Difunctionalization of Selected Cyclooctene-Fused Beta-Lactams and Beta-Amino Esters." Synthesis, May 14, 2025. https://doi.org/10.1055/a-2609-9601.

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Synthesis of novel arylfluorinated cyclic β-amino acid derivatives and β-lactams has been accomplished. Thestudies on the Pd-catalyzed arylfluorination of the ring olefin bond of cyclooctene-fused azetidine-2-one and beta-amino esters with cyclooctene skeleton were performed under versatile experimental conditions. The arylfluorinative difunctionalization of cyclooctene-fused β-lactam, performed with phenylboronic acid, in the presence of Selectfluor, azacyclic ligands, and solvents, gave a separable mixture of various fluorinated and non-fluorinated products. In contrast, arylfluorination of

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40

Ning, Yongquan, Hongzhu Chen, Yongyue Ning, Jin Zhang, and Xihe Bi. "Rhodium‐Catalyzed One‐Carbon Ring Expansion of Aziridines with Vinyl‐N‐triftosylhydrazones for the Synthesis of 2‐Vinyl Azetidines." Angewandte Chemie, January 28, 2024. http://dx.doi.org/10.1002/ange.202318072.

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Azetidines, being four‐membered N‐heterocycles, possess significant potential in contemporary medicinal chemistry owing to their favorable pharmacokinetic properties. Regrettably, the incorporation of functionalized azetidines into pharmaceutical lead structures has been impeded by the absence of efficient synthetic methods for their synthesis. In this study, a Rh‐catalyzed one‐carbon ring expansion of aziridines with vinyl‐N‐triftosylhydrazones is presented, which facilitates the synthesis of high value‐added 2‐alkenyl azetidine products. This research represents the first example of ring exp

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41

Ning, Yongquan, Hongzhu Chen, Yongyue Ning, Jin Zhang, and Xihe Bi. "Rhodium‐Catalyzed One‐Carbon Ring Expansion of Aziridines with Vinyl‐N‐triftosylhydrazones for the Synthesis of 2‐Vinyl Azetidines." Angewandte Chemie International Edition, January 28, 2024. http://dx.doi.org/10.1002/anie.202318072.

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Abstract:

Azetidines, being four‐membered N‐heterocycles, possess significant potential in contemporary medicinal chemistry owing to their favorable pharmacokinetic properties. Regrettably, the incorporation of functionalized azetidines into pharmaceutical lead structures has been impeded by the absence of efficient synthetic methods for their synthesis. In this study, a Rh‐catalyzed one‐carbon ring expansion of aziridines with vinyl‐N‐triftosylhydrazones is presented, which facilitates the synthesis of high value‐added 2‐alkenyl azetidine products. This research represents the first example of ring exp

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42

"Synthesis of Ag NPs and their catalytic activity under ultrasonic irradiations." Materials International 6, no. 1 (2024): 4. https://doi.org/10.33263/materials61.004.

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The efficient green synthesis of Ag NPs was carried out via the reduction of aqueous silver nitrate using Antidesma Parvifolium leaf extract under ultrasonic irradiation. Prepared Ag NPs were monitored through various analytical spectroscopic techniques such as FTIR, UV-visible spectroscopy, XRD, FESEM, EDS, etc. Prepared nanomaterial showed excellent to good antimicrobial results. Prepared Ag NPs showed 21 nm spherical size. Newly designed Ag NPs were used as a catalyst for the synthesis of N-(7-R)-2-oxa-6-azabicyclo[3.2.0]heptan-6-yl)isonicotinamide derivatives (4a-h) utilizing a three-compo

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Bangale, Sachin, Valmik Jondhale, Dattatraya Pansare, and Pravin Chavan. "Reusable ZnCr₂O₄ Nano Catalyzed One Pot Three-Component Cycloaddition Reaction for Synthesis of Azetidine Derivatives under Ultrasound Irradiation." Polycyclic Aromatic Compounds, October 8, 2021, 1–13. http://dx.doi.org/10.1080/10406638.2021.1983617.

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