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Journal articles on the topic 'Azine based probe'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Ghosh, Milan, Sabyasachi Ta, Jesús Sanmartín Matalobos, and Debasis Das. "Azine based smart probe for optical recognition and enrichment of Mo(vi )." Dalton Transactions 47, no. 32 (2018): 11084–90. http://dx.doi.org/10.1039/c8dt01812j.

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Single crystal X-ray structurally characterized azine derivative (L) was explored for selective detection of Molybdenum (Mo(vi)) cation through green emission. The L was very efficient for enrichment of Mo(vi) from aqueous solution.

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2

Babli, Kumari, Ghosh Abhijit, Adhikari Sangita, and Das Debasis. "Colorimetric and fluorescence recognition of zinc acetate for human breast cancer cell (MCF7) imaging : Development of a logic AND GATE." Journal of Indian Chemical Society Vol. 92, Dec 2015 (2015): 1893–902. https://doi.org/10.5281/zenodo.5599987.

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Department of Chemistry, The University of Burdwan, Burdwan-713 104, West Bengal, India <em>E-mail</em> : ddas100in@yahoo.com <em>Fax </em>: 91-342-2530452 Condensation of hydrazone derivative of 2-hydroxy naphthalene-1-carboxaldehyde with vaniline generates a yellow azine (HL) derivative that selectively recognise Zn(OAc)<sub>2</sub> both by colorimetric and fluorescence method. A binary “AND” molecular logic gate has also been constructed. Binding constant and lowest detection limit for Zn(OAc)<sub>2</sub> are 1.21 × 10<sup>4</sup> M<sup>–1</sup> and 2.29 nM respectiv

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3

Davoudabadi Farahani, Yeganeh, Zahra Salehi Rozveh, Hossein Shayegan, and Vahid Safarifard. "An Amine/Azine Functionalized MOF as a New Fluorescent Probe for Selective Sensing of Metal Ions." Proceedings 41, no. 1 (2019): 84. http://dx.doi.org/10.3390/ecsoc-23-06508.

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Metal-organic frameworks are a class of attractive materials for fluorescent sensing. Here, we report the exploration of fluorescent Zn-based amine/azine-functionalized MOF, TMU-17-NH2, ([Zn(NH2-BDC)(4-bpdb)].2DMF; NH2-BDC = amino-1,4-benzenedicarboxylic acid, 4-bpdb = 1,4-bis(4-pyridyl)-2,3-diaza-2,3-butadiene) for highly selective and sensitive detection of Fe3+ in DMF (N,N-dimethylformamide) solution. TMU-17-NH2 shows fast recognition of Fe3+ ions with a response time of <1 min and detection limit of 0.7 µM (40 ppb), and the luminescence is completely quenched in 10−3 M DMF solution of F

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4

Manigandan, Subramani, Athianna Muthusamy, Raju Nandhakumar, Charles Immanuel David, and Siddeswaran Anand. "Synthesis, characterization, theoretical investigations and fluorescent sensing behavior of oligomeric azine-based Fe³⁺Chemosensors." High Performance Polymers 34, no. 3 (2021): 321–36. http://dx.doi.org/10.1177/09540083211055675.

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Three azine oligomeric esters were synthesized, characterized by IR, UV, 1H, 13C{1H} and GPC technique, and applied to chemosensor application. The sensitivity response of the oligomers towards the metal ion was evaluated for a metal ion series. The results have shown selective and sensitive “turn off” fluorescence response towards Fe3+ ion in DMF/H2O (1:1, pH: 7.4, fluorophore: 5 μM) solution. The binding stoichiometry and binding constant of the fluorophores were calculated using the Stern–Volmer equation and Benesi–Hildebrand plots, respectively. The quenching of fluorophores on the additio

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5

Hanif, Muhammad, Muhammad Rafiq, Muhammad Mustaqeem, et al. "Intracellular and Extracellular Zinc Detection by Organic Fluorescent Receptor." Current Organic Chemistry 23, no. 24 (2020): 2664–78. http://dx.doi.org/10.2174/1385272823666191029114111.

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Keeping in view the ever growing demand and application of the organic small molecules based sensitive and selective fluorescence detection strategies for the trace metallic ions in the ecosystem, fluids and inside intracellular media, the present literature survey was focused on the recent development on the organic skeleton based fluorescence sensor for the zinc ion as Zn2+ is the second most abundant transition metal after iron in human body. The prominent organic based skeletons introduced during the past three years for zinc detection including azine, ((Z)-N´-(quinolin-2-ylmethylene)furan

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6

Shiravand, Ghasem, Alireza Badiei, Hassan Goldooz, et al. "A Fluorescent g-C3N4 Nanosensor for Detection of Dichromate Ions." Current Analytical Chemistry 16, no. 5 (2020): 593–601. http://dx.doi.org/10.2174/1573411014666180627150248.

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Background: Dichromate (Cr2O7 2-) ion is one of the carcinogenic and toxic spices in environment which can easily contaminate the environment due to its high solubility in water. Therefore, a lot of attention has been focused on the detection of Cr2O7 2- with high sensitivity and selectivity. Methods: In present work, nitrogen-rich precursor was used for synthesizing graphitic carbon nitride (g-C3N4) nanostructures through hydrothermal oxidation of g-C3N4 nanosheets. The prepared nanostructures show two distinct fluorescence emissions centered at 368 and 450 nm which are highly sensitive towar

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7

Serna, S., M. Ercibengoa, JM Marimón, and N. Reichardt. "Measuring Bacterial Glycosyl Hydrolase Activity with a Soluble Capture Probe by Mass Spectrometry." Analytical Chemistry 90, no. 21 (2018): 12543–36. https://doi.org/10.1021/acs.analchem.8b02434.

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A solution-phase enzymatic assay has been developed to track bacterial glycosyl hydrolase activity by surface-assisted MALDI-TOF mass spectrometry. Lactose was equipped with an azide-functionalized linker and was supplemented to bacterial cultures as an artificial substrate for bacterial β-galactosidase enzyme. The azide linked glycoside probe was then covalently captured on an alkyne-functionalized indium tin oxide sample plate via a bio-orthogonal copper-catalyzed azide alkyne cycloaddition (CuAAC). The noncovalent immobilization of the alkyne capture tag via hydrophobic interactions on

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8

Feng, Wei, Qicai Xiao, Lu Wang, and Yuanyong Yang. "A New Fluorescent Probe for Hydrogen Sulfide Detection in Solution and Living Cells." Molecules 28, no. 17 (2023): 6195. http://dx.doi.org/10.3390/molecules28176195.

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Since Hydrogen Sulfide (H2S) was recognized as a gas transmitter, its detection and quantification have become a hot research topic among chemists and biologists. In this area, fluorescent probes have shown great advantages: fast and strong response, low detection limit and easy manipulation. Here we developed a new fluorescent probe that detected H2S selectively among various bioactive and inorganic salts. This probe was based on the core structure of fluorescein and reacted with H2S through azide-reduction. Great linearity was achieved correlating fluorescence intensity and H2S concentration

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9

Wolfram, Stefanie, Hendryk Würfel, Stefanie H. Habenicht, et al. "A small azide-modified thiazole-based reporter molecule for fluorescence and mass spectrometric detection." Beilstein Journal of Organic Chemistry 10 (October 23, 2014): 2470–79. http://dx.doi.org/10.3762/bjoc.10.258.

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Molecular probes are widely used tools in chemical biology that allow tracing of bioactive metabolites and selective labeling of proteins and other biomacromolecules. A common structural motif for such probes consists of a reporter that can be attached by copper(I)-catalyzed 1,2,3-triazole formation between terminal alkynes and azides to a reactive headgroup. Here we introduce the synthesis and application of the new thiazole-based, azide-tagged reporter 4-(3-azidopropoxy)-5-(4-bromophenyl)-2-(pyridin-2-yl)thiazole for fluorescence, UV and mass spectrometry (MS) detection. This small fluoresce

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10

Kormos, Attila, Alexandra Egyed, Jasmine M. Olvany, et al. "A Bioorthogonal Double Fluorogenic Probe to Visualize Protein–DNA Interaction." Chemosensors 10, no. 1 (2022): 37. http://dx.doi.org/10.3390/chemosensors10010037.

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Two sets of bioorthogonally applicable, double fluorogenic probes, capable of sensing DNA–protein interactions, were prepared by installing an azide or tetrazine motif onto structurally fluorogenic, DNA sensitive frames. Installation of these bioorthogonal functions onto DNA intercalating dyes furnished these scaffolds with reactivity based fluorogenicity, rendering these probes double-fluorogenic, AND-type logic switches that require the simultaneous occurrence of a bioorthogonal reaction and interaction with DNA to trigger high intensity fluorescence. The probes were evaluated for double flu

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11

Noda, Hidetoshi, Yasuko Asada, Masakatsu Shibasaki, and Naoya Kumagai. "A fluorogenic C4N4 probe for azide-based labelling." Organic & Biomolecular Chemistry 17, no. 7 (2019): 1813–16. http://dx.doi.org/10.1039/c8ob02695e.

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12

Baghapour, Shaghayegh, Jasmine Nehema, Wen Qi Zhang, et al. "Surface Functionalised Optical Fibre for Detection of Hydrogen Sulphide." Biosensors 13, no. 11 (2023): 949. http://dx.doi.org/10.3390/bios13110949.

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Dysregulated production of hydrogen sulphide in the human body has been associated with various diseases including cancer, underlining the importance of accurate detection of this molecule. Here, we report the detection of hydrogen sulphide using fluorescence-emission enhancement of two 1,8-naphthalimide fluorescent probes with an azide moiety in position 4. One probe, serving as a control, featured a methoxyethyl moiety through the imide to evaluate its effectiveness for hydrogen sulphide detection, while the other probe was modified with (3-aminopropyl)triethoxysilane (APTES) to enable direc

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13

Tan, Xiao-Dan, Man Pan, Shuai Gao, Yong Zheng, Jing Shi, and Yi-Ming Li. "A diubiquitin-based photoaffinity probe for profiling K27-linkage targeting deubiquitinases." Chemical Communications 53, no. 73 (2017): 10208–11. http://dx.doi.org/10.1039/c7cc05504h.

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14

Kasza, Patryk, Przemysław W. Szafrański, Joanna Fedorowicz, et al. "Safirinium Fluorescent “Click” Molecular Probes: Synthesis, CuAAC Reactions, and Microscopic Imaging." Molecules 30, no. 3 (2025): 731. https://doi.org/10.3390/molecules30030731.

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Fluorescent labeling utilizing Cu(I)-catalyzed azide–alkyne cycloaddition reactions (CuAAC) is among the leading applications of the “click” chemistry strategy. Fluorescent probes for this approach can be constructed by linking an azide or alkyne group to a fluorophore, such as the recently developed Safirinium derivatives. These compounds are water-soluble, highly fluorescent heterocycles based on 1,2,4-triazolium, with significant potential for various labeling applications, although they have not yet been converted to azide or alkyne probes. Herein, we report the synthesis of Safirinium-bas

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15

Sola, Laura, Laura Abdel Mallak, Francesco Damin, Alessandro Mussida, Dario Brambilla, and Marcella Chiari. "Optimization of Functional Group Concentration of N, N-Dimethylacrylamide-based Polymeric Coatings and Probe Immobilization for DNA and Protein Microarray Applications." Micromachines 14, no. 2 (2023): 302. http://dx.doi.org/10.3390/mi14020302.

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We report here a deep investigation into the effect of the concentration of a polymeric coating’s functional groups on probe density immobilization with the aim of establishing the optimal formulation to be implemented in specific microarray applications. It is widely known that the ideal performance of a microarray strictly depends on the way probes are tethered to the surface since it influences the way they interact with the complementary target. The N, N-dimethylacrylamide-based polymeric coating introduced by our research group in 2004 has already proven to offer great flexibility for the

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16

Kim, Ho Won, Myung Gil Choi, Hyunji Park, Jung Woo Lee, and Suk-Kyu Chang. "Single molecular multianalyte signaling of sulfide and azide ions by a nitrobenzoxadiazole-based probe." RSC Advances 5, no. 6 (2015): 4623–27. http://dx.doi.org/10.1039/c4ra10690c.

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17

Lafreniere, Matthew A., Geneviève F. Desrochers, Kedous Mekbib, and John Paul Pezacki. "An affinity-based probe for methyltransferase enzymes based on sinefungin." Canadian Journal of Chemistry 95, no. 10 (2017): 1059–63. http://dx.doi.org/10.1139/cjc-2017-0168.

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Epigenetics control numerous cellular processes such as gene transcription, signal transduction, and protein stabilization. An understanding of epigenetic mechanisms can lead to the development of therapeutic agents for various diseases. Herein, we report the design and synthesis of a sinefungin affinity-probe (BpyneSF) that targets methyltranferase enzymes and proteins involved in recognition of methylation. This probe contains a bioorthogonal alkyne residue for conjugation using the copper-catalyzed azide–alkyne cycloaddition and a photoactivatable crosslinker group for covalent attachment o

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18

Panda, Snigdharani, Arpita Jadav, Niranjan Panda, and Sasmita Mohapatra. "A novel carbon quantum dot-based fluorescent nanosensor for selective detection of flumioxazin in real samples." New Journal of Chemistry 42, no. 3 (2018): 2074–80. http://dx.doi.org/10.1039/c7nj04358a.

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19

Li, Zongyang, Yaxuan Li, Wenxu Chang, et al. "Synthesis and Fluorescent Properties of Aminopyridines and the Application in “Click and Probing”." Molecules 27, no. 5 (2022): 1596. http://dx.doi.org/10.3390/molecules27051596.

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Unsubstituted pyridin-2-amine has a high quantum yield and is a potential scaffold for a fluorescent probe. However, the facile access to conjugated highly substituted aminopyridines and the study of their fluorescent properties is scarce. In this paper, synthesis and fluorescent properties of multisubstituted aminopyridines were studied based on a recently developed Rh-catalyzed coupling of vinyl azide with isonitrile to form a vinyl carbodiimide intermediate, following tandem cyclization with an alkyne. An aminopyridine substituted with an azide group as a potential probe was further designe

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20

Qiao, Qinglong, Miao Zhao, Haijing Lang, Deqi Mao, Jingnan Cui, and Zhaochao Xu. "A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells." RSC Adv. 4, no. 49 (2014): 25790–94. http://dx.doi.org/10.1039/c4ra03725a.

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21

Yang, Yanbo, Zhiyi Yao, Baiyang Tang, et al. "Visual detection of Cu(ii) ions based on a simple pyrene derivative using click chemistry." Anal. Methods 6, no. 14 (2014): 4977–81. http://dx.doi.org/10.1039/c4ay00880d.

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A ratiometric fluorescent probe for the visual detection of Cu<sup>2+</sup>in aqueous media has been developed based on a “click” reaction between a pyrene azide and a positively charged terminal alkyne.

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22

Zhao, Miao, Hua Li, Hui Li, Qinglong Qiao, Cheng Cao, and Zhaochao Xu. "A turn-on fluorescent probe for hydrogen sulfide and its application in living cells." RSC Advances 5, no. 105 (2015): 86355–58. http://dx.doi.org/10.1039/c5ra15384k.

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Herein, we described a probe for H<sub>2</sub>S detection based on the reduction of azide to amine. This probe was highly sensitive and selective toward H<sub>2</sub>S and successfully applied for H<sub>2</sub>S fluorescent imaging in living cells.

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23

Ji, Xiaohui, Dan Zhang, Le Li, Lingxia Jin та Rui Wu. "Efficient β-Carboline Alkaloid-Based Probe for Highly Sensitive Imaging of Endogenous Glutathione in Wheat Germ Tissues". International Journal of Analytical Chemistry 2020 (15 вересня 2020): 1–7. http://dx.doi.org/10.1155/2020/8675784.

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Discriminative detection of GSH is achieved by employing a highly sensitive and selective fluorescent probe (KL-DN) that bears β-carboline alkaloid as a potential fluorophore and an azide group as the recognition unit. A rapid fluorescence off-on change is caused by special redox reaction; KL-DN has the capability of monitoring endogenous GSH in wheat germ tissues, indicating that this probe holds great potential for biological applications in plant tissues.

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24

Adhikari, Susanta, Subhajit Guria, Avijit Ghosh, Abhishek Pal, and Debasis Das. "A curcumin derived probe for colorimetric detection of azide ions in water." New Journal of Chemistry 41, no. 24 (2017): 15368–72. http://dx.doi.org/10.1039/c7nj03266h.

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25

Fu, Ying-Long, Hao Li, Xiu-Zhi Wei, and Qin-Hua Song. "BODIPY-based hydrazine as a fluorescent probe for sensitive and selective detection of nitric oxide: a new strategy." Journal of Materials Chemistry B 7, no. 24 (2019): 3792–95. http://dx.doi.org/10.1039/c9tb00626e.

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A novel fluorescent probe 8-HB was developed with a BODIPY as a fluorophore and 8-substituted hydrazine as a reactive site for sensitive and selective detection of nitric oxide (NO), generating major fluorescent dehydrazinated BODIPY and minor non-fluorescent azide BODIPY.

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26

Zhang, Jie, Yasi Gao, Xueying Kang, et al. "o,o-Difluorination of aromatic azide yields a fast-response fluorescent probe for H2S detection and for improved bioorthogonal reactions." Organic & Biomolecular Chemistry 15, no. 19 (2017): 4212–17. http://dx.doi.org/10.1039/c7ob00830a.

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27

Wu, I., Dan Zhang, and Xuanjun Zhang. "A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H2S." Chemosensors 9, no. 11 (2021): 298. http://dx.doi.org/10.3390/chemosensors9110298.

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Inspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to combine both current signal and fluorescence. Fluorescent probes were conjugated to the nanochannel surface by covalent bonds. By utilizing the specific reduction of azide groups in the probe to amino groups by H2S, a synchronizing change in fluorescence and nanochannel surface charge was established

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28

Ma, Xiaofeng, Jinghui Cheng, Jiaoyan Liu, Xiangge Zhou, and Haifeng Xiang. "Ratiometric fluorescent pH probes based on aggregation-induced emission-active salicylaldehyde azines." New Journal of Chemistry 39, no. 1 (2015): 492–500. http://dx.doi.org/10.1039/c4nj01908c.

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AIE-active salicylaldehyde azines (SAs) display strong blue, green, and red fluorescence with large Stokes shifts in MeCN–water and solid medium and can be used as ratiometric fluorescent pH probes in water and test paper.

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29

Danilkina, Natalia A., Ekaterina V. Andrievskaya, Anna V. Vasileva, et al. "4-Azidocinnoline—Cinnoline-4-amine Pair as a New Fluorogenic and Fluorochromic Environment-Sensitive Probe." Molecules 26, no. 24 (2021): 7460. http://dx.doi.org/10.3390/molecules26247460.

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A new type of fluorogenic and fluorochromic probe based on the reduction of weakly fluorescent 4-azido-6-(4-cyanophenyl)cinnoline to the corresponding fluorescent cinnoline-4-amine was developed. We found that the fluorescence of 6-(4-cyanophenyl)cinnoline-4-amine is strongly affected by the nature of the solvent. The fluorogenic effect for the amine was detected in polar solvents with the strongest fluorescence increase in water. The environment-sensitive fluorogenic properties of cinnoline-4-amine in water were explained as a combination of two types of fluorescence mechanisms: aggregation-i

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30

Thirumalaivasan, Natesan, Parthiban Venkatesan, and Shu-Pao Wu. "Highly selective turn-on probe for H2S with imaging applications in vitro and in vivo." New Journal of Chemistry 41, no. 22 (2017): 13510–15. http://dx.doi.org/10.1039/c7nj02869e.

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31

Debets, Marjoke F., Omur Y. Tastan, Simon P. Wisnovsky, et al. "Metabolic precision labeling enables selective probing of O-linkedN-acetylgalactosamine glycosylation." Proceedings of the National Academy of Sciences 117, no. 41 (2020): 25293–301. http://dx.doi.org/10.1073/pnas.2007297117.

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Protein glycosylation events that happen early in the secretory pathway are often dysregulated during tumorigenesis. These events can be probed, in principle, by monosaccharides with bioorthogonal tags that would ideally be specific for distinct glycan subtypes. However, metabolic interconversion into other monosaccharides drastically reduces such specificity in the living cell. Here, we use a structure-based design process to develop the monosaccharide probeN-(S)-azidopropionylgalactosamine (GalNAzMe) that is specific for cancer-relevant Ser/Thr(O)–linkedN-acetylgalactosamine (GalNAc) glycosy

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32

Luijkx, Yvette M. C. A., Anniek J. Henselijn, Gerlof P. Bosman та ін. "Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts". Molecules 27, № 5 (2022): 1615. http://dx.doi.org/10.3390/molecules27051615.

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Fucosidases are associated with several pathological conditions and play an important role in the health of the human gut. For example, fucosidases have been shown to be indicators and/or involved in hepatocellular carcinoma, breast cancer, and helicobacter pylori infections. A prerequisite for the detection and profiling of fucosidases is the formation of a specific covalent linkage between the enzyme of interest and the activity-based probe (ABP). The most commonly used fucosidase ABPs are limited to only one of the classes of fucosidases, the retaining fucosidases. New approaches are needed

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33

Zhang, Jingyu, and Wei Guo. "A new fluorescent probe for gasotransmitter H2S: high sensitivity, excellent selectivity, and a significant fluorescence off–on response." Chem. Commun. 50, no. 32 (2014): 4214–17. http://dx.doi.org/10.1039/c3cc49605h.

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Trindade, Alexandre F., Raquel F. M. Frade, Ermelinda M. S. Maçôas, et al. "“Click and go”: simple and fast folic acid conjugation." Org. Biomol. Chem. 12, no. 20 (2014): 3181–90. http://dx.doi.org/10.1039/c4ob00150h.

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A novel approach for conjugation of folic acid is presented allowing for its quantitative conjugation with several types of molecules (fluorescent probes) and materials (polymers and silica) based on strain-promoted alkyne–azide cycloaddition, without the need for expensive chromatographic purifcation.

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Bennett, Kristen, Natalie C. Sadler, Aaron T. Wright, Chris Yeager, and Michael R. Hyman. "Activity-Based Protein Profiling of Ammonia Monooxygenase in Nitrosomonas europaea." Applied and Environmental Microbiology 82, no. 8 (2016): 2270–79. http://dx.doi.org/10.1128/aem.03556-15.

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ABSTRACTNitrosomonas europaeais an aerobic nitrifying bacterium that oxidizes ammonia (NH3) to nitrite (NO2−) through the sequential activities of ammonia monooxygenase (AMO) and hydroxylamine dehydrogenase (HAO). Many alkynes are mechanism-based inactivators of AMO, and here we describe an activity-based protein profiling method for this enzyme using 1,7-octadiyne (17OD) as a probe. Inactivation of NH4+-dependent O2uptake byN. europaeaby 17OD was time- and concentration-dependent. The effects of 17OD were specific for ammonia-oxidizing activity, andde novoprotein synthesis was required to ree

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36

Lepage, Mathieu L., Antoine Mirloup, Manon Ripoll, et al. "Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores." Beilstein Journal of Organic Chemistry 11 (May 6, 2015): 659–67. http://dx.doi.org/10.3762/bjoc.11.74.

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The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide–alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding.

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Kamihira, Rie, and Yoichi Nakao. "Preparation and Application of a Chemical Probe for Identifying the Targets of the Marine Cyclic Peptide Kapakahine A." Molecules 27, no. 3 (2022): 1072. http://dx.doi.org/10.3390/molecules27031072.

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Marine organisms are a rich source of bioactive secondary metabolites. Although many marine natural products with bioactivities have been isolated, successful elucidation of their mechanisms of action remains limited. In this study, we prepared a probe molecule based on the marine cyclic peptide kapakahine A (1) by introducing a linker with an azide terminal group, which enables the introduction of fluorescent groups for the effective monitoring of subcellular localization, or coupling to affinity beads for the pull-down of target proteins. The results of LC/MS/MS measurements, ProteinPilot an

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38

Zhou, Fan, Kexin Zhang, Gaofei Li, et al. "Keto-salicylaldehyde azine: a kind of novel building block for AIEgens and its application in tracking lipid droplets." Materials Chemistry Frontiers 4, no. 10 (2020): 3094–102. http://dx.doi.org/10.1039/d0qm00405g.

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KSA-based fluorescent probes exhibit higher flexibility in tuning emission color and selectivity in LDs, which could be applied as a reporter for monitoring LDs changes in dynamic process and larva zebrafish development.

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39

Renault, Kévin, Pierre-Yves Renard, and Cyrille Sabot. "Photophysical properties of quinoxalin-2(1H)-ones: application in the preparation of an azide-based fluorogenic probe for the detection of hydrogen sulfide." New Journal of Chemistry 41, no. 18 (2017): 10432–37. http://dx.doi.org/10.1039/c7nj01893b.

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40

Bonneure, Eli, Amber De Baets, Sam De Decker, et al. "Altering the Sex Pheromone Cyclo(l-Pro-l-Pro) of the Diatom Seminavis robusta towards a Chemical Probe." International Journal of Molecular Sciences 22, no. 3 (2021): 1037. http://dx.doi.org/10.3390/ijms22031037.

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As a major group of algae, diatoms are responsible for a substantial part of the primary production on the planet. Pennate diatoms have a predominantly benthic lifestyle and are the most species-rich diatom group, with members of the raphid clades being motile and generally having heterothallic sexual reproduction. It was recently shown that the model species Seminavis robusta uses multiple sexual cues during mating, including cyclo(l-Pro-l-Pro) as an attraction pheromone. Elaboration of the pheromone-detection system is a key aspect in elucidating pennate diatom life-cycle regulation that cou

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Burilov, Vladimir A., Guzaliya A. Fatikhova, Mariya N. Dokuchaeva, et al. "Synthesis of new p-tert-butylcalix[4]arene-based polyammonium triazolyl amphiphiles and their binding with nucleoside phosphates." Beilstein Journal of Organic Chemistry 14 (July 31, 2018): 1980–93. http://dx.doi.org/10.3762/bjoc.14.173.

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The synthesis of new calix[4]arenes adopting a cone stereoisomeric form bearing two or four azide fragments on the upper rim and water-soluble triazolyl amphiphilic receptors with two or four polyammonium headgroups via copper-catalyzed azide–alkyne cycloaddition reaction has been performed for the first time. It was found that the synthesized macrocycles form stable aggregates with hydrodynamic diameters between 150–200 nm and electrokinetic potentials about +40 to +60 mV in water solutions. Critical aggregation concentration (CAC) values were measured using a micelle method with pyrene and e

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Kopcial, Michal, Blazej A. Wojtczak, Renata Kasprzyk, Joanna Kowalska, and Jacek Jemielity. "N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, Reactivity, and Applications to the Study of Cap-Binding Proteins." Molecules 24, no. 10 (2019): 1899. http://dx.doi.org/10.3390/molecules24101899.

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The mRNA 5′ cap consists of N7-methylguanosine bound by a 5′,5′-triphosphate bridge to the first nucleotide of the transcript. The cap interacts with various specific proteins and participates in all key mRNA-related processes, which may be of therapeutic relevance. There is a growing demand for new biophysical and biochemical methods to study cap–protein interactions and identify the factors which inhibit them. The development of such methods can be aided by the use of properly designed fluorescent molecular probes. Herein, we synthesized a new class of m7Gp3G cap derivatives modified with an

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Sakkhachornphop, Supachai, Weeraya Thongkum, and Chatchai Tayapiwatana. "Novel 3′-Processing Integrase Activity Assay by Real-Time PCR for Screening and Identification of HIV-1 Integrase Inhibitors." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/853891.

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The 3′-end processing (3′P) of each viral long terminal repeat (LTR) during human immunodeficiency virus type-1 (HIV-1) integration is a vital step in the HIV life cycle. Blocking the 3′P using 3′P inhibitor has recently become an attractive strategy for HIV-1 therapeutic intervention. Recently, we have developed a novel real-time PCR based assay for the detection of 3′P activityin vitro. The methodology usually involves biotinylated HIV-1 LTR, HIV-1 integrase (IN), and specific primers and probe. In this novel assay, we designed the HIV-1 LTR substrate based on a sequence with a homology to H

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Bagar, Tanja, Kirsten Altenbach, Nick D. Read, and Mojca Benčina. "Live-Cell Imaging and Measurement of Intracellular pH in Filamentous Fungi Using a Genetically Encoded Ratiometric Probe." Eukaryotic Cell 8, no. 5 (2009): 703–12. http://dx.doi.org/10.1128/ec.00333-08.

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ABSTRACT A novel, genetically encoded, ratiometric pH probe (RaVC) was constructed to image and measure intracellular pH in living hyphae of Aspergillus niger. RaVC is a chimeric protein based on the pH-sensitive probe pHluorin, which was partially codon optimized for expression in Aspergillus. Intracellular pH imaging and measurement was performed by simultaneous, dual-excitation confocal ratio imaging. The mean cytoplasmic pH measured was 7.4 to 7.7 based on calibrating RaVC in situ within nigericin-treated hyphae. Pronounced, longitudinal cytoplasmic pH gradients were not observed in the ap

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Washington-Hughes, Clorissa L., Yixing Cheng, Xinrui Duan, Li Cai, L. Andrew Lee, and Qian Wang. "In Vivo Virus-Based Macrofluorogenic Probes Target Azide-Labeled Surface Glycans in MCF-7 Breast Cancer Cells." Molecular Pharmaceutics 10, no. 1 (2012): 43–50. http://dx.doi.org/10.1021/mp3002528.

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Shang, Pei, Jie Wu, Xiaoyu Shi, Zhidan Wang, Fei Song, and Shouxin Liu. "Synthesis of Thermo-Responsive Block-Graft Copolymer Based on PCL and PEG Analogs, and Preparation of Hydrogel via Click Chemistry." Polymers 11, no. 5 (2019): 765. http://dx.doi.org/10.3390/polym11050765.

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Thermo-responsive cross-linkable mPEG-b-[PCL-g-(MEO2MA-co-OEGMA)]-b-mPEG was synthesized by ring-opening polymerization (ROP) and atom transfer radical polymerization (ATRP). Then, the cross-linkable block-graft copolymer was used to prepare hydrogel via a copper-catalyzed 1,3-dipolar azide-alkyne cycloaddition reaction. The chemical structure and composition of copolymer were characterized by proton nuclear magnetic resonance (1H NMR), Fourier-transform infrared (FT-IR) and gel permeation chromatography (GPC). The self-assembly behaviors of the copolymer in aqueous solution were studied by UV

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Vasilyeva, Svetlana V., Vyacheslav V. Filichev, and Alexandre S. Boutorine. "Application of Cu(I)-catalyzed azide–alkyne cycloaddition for the design and synthesis of sequence specific probes targeting double-stranded DNA." Beilstein Journal of Organic Chemistry 12 (June 30, 2016): 1348–60. http://dx.doi.org/10.3762/bjoc.12.128.

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Efficient protocols based on Cu(I)-catalyzed azide–alkyne cycloaddition were developed for the synthesis of conjugates of pyrrole–imidazole polyamide minor groove binders (MGB) with fluorophores and with triplex-forming oligonucleotides (TFOs). Diverse bifunctional linkers were synthesized and used for the insertion of terminal azides or alkynes into TFOs and MGBs. The formation of stable triple helices by TFO-MGB conjugates was evaluated by gel-shift experiments. The presence of MGB in these conjugates did not affect the binding parameters (affinity and triplex stability) of the parent TFOs.

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Qiao, Zhen, Hongyi Zhang, KeWei Wang, and Yanru Zhang. "A highly sensitive and responsive fluorescent probe based on 6-azide-chroman dye for detection and imaging of hydrogen sulfide in cells." Talanta 195 (April 2019): 850–56. http://dx.doi.org/10.1016/j.talanta.2018.12.014.

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Puthiyedath, Thasnim, and Damodaran Bahulayan. "A click-generated triazole tethered oxazolone-pyrimidinone dyad: A highly selective colorimetric and ratiometric FRET based fluorescent probe for sensing azide ions." Sensors and Actuators B: Chemical 239 (February 2017): 1076–86. http://dx.doi.org/10.1016/j.snb.2016.08.044.

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Sakoula, Dimitra, Garrett J. Smith, Jeroen Frank, et al. "Universal activity-based labeling method for ammonia- and alkane-oxidizing bacteria." ISME Journal 16, no. 4 (2021): 958–71. http://dx.doi.org/10.1038/s41396-021-01144-0.

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AbstractThe advance of metagenomics in combination with intricate cultivation approaches has facilitated the discovery of novel ammonia-, methane-, and other short-chain alkane-oxidizing microorganisms, indicating that our understanding of the microbial biodiversity within the biogeochemical nitrogen and carbon cycles still is incomplete. The in situ detection and phylogenetic identification of novel ammonia- and alkane-oxidizing bacteria remain challenging due to their naturally low abundances and difficulties in obtaining new isolates from complex samples. Here, we describe an activity-based

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