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1

Hargreaves, Judith Ann. Interactions between azole antifungal agents and human microsomal cytochrome P450. Manchester: University of Manchester, 1995.

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2

Hrnčárová, Nataša. Zákon o azyle: Komentár. Praha: C.H. Beck, 2012.

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3

R, Manson William, and Peale C. George, eds. Atila, azote de Dios. Newark, Del: Juan de la Cuesta, 2009.

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4

Gesualdo, Alejandro. El azote de Dios. [Buenos Aires]: A. Gesualdo, 2006.

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5

editor, Peale C. George, and Sánchez Jiménez Raquel editor, eds. La Cristianísima Lis y Azote de la Herejía. Newark, Delaware: Juan de la Cuesta, 2021.

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6

Gribble, Gordon W., ed. Metalation of Azoles and Related Five-Membered Ring Heterocycles. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31791-0.

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7

Zirngibl, Ludwig. Antifungal azoles: A comprehensive survey of their structures and properties. Weinheim: Wiley-VCH, 1998.

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8

Sidat, Rehana. The synthesis and analysis of spirobenz-1,3-azoles and related compounds. Leicester: De Montfort University, 1997.

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9

Büchel, Karl Heinz. Die Bedeutung der Produktinnovation in der Chemie am Beispiel der Azol-Antimykotika und -Fungizide. Wiesbaden: VS Verlag für Sozialwissenschaften, 1989. http://dx.doi.org/10.1007/978-3-322-88172-4.

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10

MacDonald, K. Bruce. Indicator of risk of water contamination: Nitrogen component. Ottawa: Agriculture and Agri-Food Canada, 1996.

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11

White, T. C. R. The inadequate environment: Nitrogen and the abundance of animals. Berlin: Springer-Verlag, 1993.

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12

Valentin, Lopyrev, ed. Nitroazoles: Synthesis, structure and applications. Dordrecht: Springer, $c c2009., 2009.

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13

Katritzky, Alan R. Advances in heterocyclic chemistry. San Diego, Calif: Academic Press, 2000.

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14

International Congress on N [Triple-bond] Nitrogen Fixation (7th 1988 Cologne, Germany). Nitrogen fixation: Hundred years after : proceedings of the 7th International Congress on N [Triple-bond] Nitrogen Fixation, Köln (Cologne), F.R.G., March 13-20, 1988. Stuttgart: G. Fischer, 1988.

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15

J, Aherne, Farrell Edward P, and Ireland Environmental Protection Agency, eds. Critical loads and levels: Determination and mapping of critical loads for sulphur and nitrogen and critical levels for ozone in Ireland : final report. Wexford: E.P.A., 2000.

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16

Liwang, Ma, Ahuja L, and Bruulsema Tom, eds. Quantifying and understanding plant nitrogen uptake systems modeling. Boca Raton: CRC Press, 2008.

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17

Lemm, Jeffrey M. ADVANCES IN HETEROCYCLIC CHEMISTRY V41. Burlington: Elsevier, 1987.

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18

Dixon, R. O. D. Nitrogen fixation in plants. Glasgow: Blackie, 1986.

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19

T, Wheeler C., ed. Nitrogen fixation in plants. Glasgow: Blackie, 1986.

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20

Microbiology, American Society for, and Knovel (Firm), eds. Nitrification. Washington, DC: ASM Press, 2011.

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21

Sousa, Trelita De. Global implications of the nitrogen cycle. Newcastle upon Tyne: Cambridge Scholars Publishing, 2020.

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22

National Research Council (U.S.). Subcommittee on Nitrogen Usage in Ruminants., ed. Ruminant nitrogen usage. Washington, D.C: National Academy Press, 1985.

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23

Sprent, Janet I. The ecology of the nitrogen cycle. Cambridge [Cambridgeshire]: Cambridge University Press, 1987.

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24

Smith, Stephanie J., Rohini J. Manuel, and Christopher C. Kibbler. Aspergillus species. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0010.

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There are more than 200 Aspergillus species, with over 30 known to be human pathogens. The fungus is also commercially important. Aspergillus niger is the source of enzymes such as amylases, lipases, and proteases and is used to produce the majority of the world’s citric acid. Diseases caused by Aspergillus species can vary widely, from superficial colonization to invasive and allergic disease. Mortality from invasive disease remains high, despite an increase in the number of antifungals available for therapy. Azole resistance is increasing, especially in Europe, and appears to be related to the use of azoles for agriculture.
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25

Kemper, Carol A., and Stanley C. Deresinski. Fungal arthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0106.

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Fungal infections of the musculoskeletal system are uncommon and diagnosis is often delayed. Infection is more common in the immunocompromised patient. The most important infections are due to candida species, Histoplasmosis capsulatum, Blastomycosis dermatiditis, and Coccidioides immitis. Amphotericin B remains the initial therapeutic agent of choice for many serious fungal infections, especially for those who are severely immunosuppressed, have life-threatening or central nervous system disease, or who have failed azole therapy.
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26

Restrepo, Angela, Angel A. Gónzalez, and Beatriz L. Gómez. Endemic dimorphic fungi. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0016.

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Endemic dimorphic infections are acquired by inhalation of fungal spores which undergo a thermal transition to a yeast-like phase in the host. The causative organisms are geographically restricted and are isolated from the environment; likewise, the infections are associated with people living in, or visiting, these endemic regions. The clinical presentations range from asymptomatic to chronic, and disseminated, depending on the host immune status and other risk factors. The infections and their causative agents are: histoplasmosis (Histoplasma capsulatum), paracoccidioidomycosis (Paracoccidioides brasiliensis/lutzii), blastomycosis (Blastomyces dermatitidis/gilchristii), coccidioidomycosis (Coccidioides immitis/posadasii), talaromycosis (previously penicilliosis; Talaromyces [Penicillium] marneffei), and emmonsiosis (Emmonsia species). Diagnosis relies on microscopy and culture, histology, and immunological detection. Owing to their infectious nature, all of these organisms must be handled using biosafety level-3 containment. Treatment is based around azole administration, usually itraconazole, with amphotericin B for the more severe forms or for the most at risk patients.
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27

White, P. Lewis, and Rosemary A. Barnes. Molecular diagnosis of fungal disease. Edited by Christopher C. Kibbler, Richard Barton, Neil A. R. Gow, Susan Howell, Donna M. MacCallum, and Rohini J. Manuel. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755388.003.0043.

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Molecular techniques to aid in the diagnosis of fungal disease have been in use for over two decades. However, for polymerase chain reaction (PCR) to gain widespread acceptance outside of specialist centres, methodology must be standardized and in line with general microbiological molecular diagnostics assays, yet for infections other than fungal disease. Apart from Aspergillus PCR, standardized methodology is lacking. It is also essential to identify the optimal role for an assay. Whether this is to confirm a specific disease in symptomatic patients or to exclude disease and prevent the unnecessary use of antifungals will, in part, be determined by prevalence, but will also, along with the disease manifestation, dictate specimen choice and subsequent methodological procedure. This chapter will focus on disease processes determining optimal sample types, before concentrating on the clinical validation of molecular tests for the diagnosis of the main causes of invasive fungal disease, concluding with recent developments. The clinical utility of molecular approaches and potential future benefits that can address emerging issues, such as azole resistance, will also be discussed.
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28

Museum, Azle Historical. Azle. Arcadia Publishing, 2012.

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29

Museum, Azle Historical. Azle. Arcadia Publishing, 2012.

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30

LIZCANO, Mariano. Azote de Dios. Independently Published, 2022.

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31

Anderson, Moira. Azule/blue (Finding Colors). Heinemann, 2005.

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32

Arce, Daniel. Azote de Los Modernos. Independently Published, 2021.

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33

Grimmett, M. R., Kenneth Schofield, and B. R. T. Keene. Heteroaromatic Nitrogen Compounds: The Azoles. University of Cambridge ESOL Examinations, 2011.

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34

ATILA. EL AZOTE DE DIOS. ZETA BOLSILLO, 2008.

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35

Mim. Noé et Azote: Super balèze! 2015.

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36

William, Dietrich. Atila: El azote de Dios. Ediciones B, 2006.

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37

Atila - El Azote de Dios. Palabra Ediciones, 2001.

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38

Dietrich, William. Atila: El Azote de Dios. B. Mexico, Ediciones, S.A. de C.V., 2008.

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39

William, Dietrich. Atila - El Azote de Dios. Ediciones B, 2006.

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40

Dobson, James C. Azote de La Rivalidad Entre Hermanos. Editorial Unlimited, 1991.

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41

King, J. Robert. Ciclo Embestida nº 03/03 Azote. Minotauro, 2004.

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42

Kuznetsov, Aleksey. Azoles: Synthesis, Properties, Applications and Perspectives. IntechOpen, 2021.

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43

History of Azle community, Texas. Dallas, Tex: Curtis Media Corp., 1986.

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44

Zirngibl, L. Azoles, Antifungal Active Substances: Syntheses and Uses. Wiley-VCH Verlag GmbH, 1998.

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45

Mim. Noé et Azote: Bienvenue chez les trolls! 2015.

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46

Mim. Noé et Azote: Un ami au poil! 2015.

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47

Charles Belfoure Martin P. Azola. The Azola Legacy - 50 Years REBUILDING BALTIMORE. Azola Building Services, 2018.

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48

Azoles - Synthesis, Properties, Applications and Perspectives [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.87765.

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49

Star Wars. 11, El azote de Shu-Torun. Planeta, 2021.

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50

Gribble, Gordon W. Metalation of Azoles and Related Five-Membered Ring Heterocycles. Springer, 2012.

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