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Dissertations / Theses on the topic 'B cell memory'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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1

Bell, Jennifer. "Studies on B cell memory." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/13873.

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2

Weber, Grace E. "Memory B Cell Dysfunction in Human Malaria." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1512731469728517.

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3

Morrison, Vicky L. "Innate and cognate roles of B cells in T cell differentiation and memory." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4873.

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B cells recognise antigens on micro-organisms through their B cell receptor (BCR) and via Toll-like receptors (TLRs), and thus respond in both innate and adaptive manners during the subsequent immune response. Innate recognition through TLRs has the potential to alter the behaviour of whole B cell populations. I show, here, that MyD88-dependent activation of B cells via TLR2 or TLR9 causes the rapid loss of expression of CD62L, by metalloproteinasedependent shedding, resulting in the exclusion of these cells from lymph nodes and Peyer’s patches, but not the spleen. Moreover, systemic infection
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4

Faenzi, Elisa <1981&gt. "Analysis of the memory B cell response against glycoconjugate vaccines." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4472/.

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The development of vaccines directed against polysaccharide capsules of S. pneumoniae, H. influenzae and N. meningitidis have been of great importance in preventing potentially fatal infections. Bacterial capsular polysaccharides are T-cell-independent antigens that induce specific antibody response characterized by IgM immunoglobulins, with a very low IgG class switched response and lack of capability of inducing a booster response. The inability of pure polysaccharides to induce sustained immune responses has required the development of vaccines containing polysaccharides conjugated to a car
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5

Murugan, Rajagopal. "Protective memory B cell response in controlled human malaria infection." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19695.

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Antikörper gegen Circumsporozoite protein (CSP), ein Oberflächenantigen von Plasmodium falciparum (Pf), können sterile Immunität hervorrufen und dadurch die Entwicklung von Malaria im Tierversuch verhindern. Im Menschen werden protektive B-Zell Gedächtnisantworten gegen CSP durch natürliche Malariaerkrankung bzw. Vakzinierung jedoch nur unzureichend erzeugt. - Für die Entwicklung von Gedächtnis-B-Zellen stellt die Affinitätsreifung, welche durch somatische Immungobulin Hypermutation sowie der nachfolgenden Selektion von B-Zellen mit verbesserter Antigenaffinität charakterisiert ist, eine
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6

Monaghan, Tanya Marie. "Circulating antibody and memory B cell responses to Clostridium difficile toxins A and B." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595681.

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In C. difficile infection (COl), the antibody-mediated immune response to secreted toxins A and B appears to be important in determining the nature of clinical disease. The aim of this study was to evaluate multiple aspects of the humoral immune response to C. difficife toxins A and B in patients with C. difficile-associated disease (COAO), among which included subjects with inflammatory bowel disease. Humoral immune measurements were also quantified for healthy controls and patients with cystic fibrosis (CF) who have been reported to rarely develop COl. Isolated peripheral blood mononuclear c
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7

Trück, Johannes. "B cell response to pneumococcal vaccines." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:4bbccd8c-febd-4713-a97b-d6a8a08e3979.

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Streptococcus pneumoniae is a significant cause of mortality and morbidity in both children and older adults, with infection resulting in invasive disease, pneumonia and otitis media. The inclusion of pneumococcal conjugate vaccines in routine infant immunisation programmes has had a major impact on disease rates. Vaccine-induced protection against pneumococcal infection is thought to be mediated by the generation of persistent serotype-specific functional antibodies and antigen-specific memory B cells, the latter capable of generating a rapid secondary antibody response on re-exposure to anti
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8

Mietzner, Brun Henning. "IgG memory B cell antibodies in patients with systemic lupus erythematosus." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2009. http://dx.doi.org/10.18452/16078.

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Die beständige Autoantikörperproduktion in Patienten mit Systemischem Lupus Erythematodes (SLE) suggeriert die Existenz eines autoreaktiven humoralen Gedächtnisses; die Häufigkeit selbstreaktiver Gedächtnis-B-Zellen in SLE wurde jedoch noch nicht ermittelt. Unter normalen Umständen exprimieren neu gebildete B-Zellen im Knochenmark Autoantikörper mit hoher Frequenz, darunter auch antinukleäre Antikörper. Diese autoreaktiven B Zellen unterliegen einer strengen Überwachung an zwei Kontrollpunkten für Selbsttoleranz, einer im Knochenmark und einer in der Peripherie. Im Gegensatz dazu steht SLE mit
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9

Muhammad, Khalid. "Longterm impact of anti-CD20 mediated transient B cell depletion on memory B cells in patients with rheumatoid arthritis." Doctoral thesis, kostenfrei, 2009. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-36319.

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B-Lymphozyten leisten unterschiedliche Beiträge zur Pathophysiologie der Rheumatoiden Arthritis. Sie produzieren Autoantikörper, präsentieren Autoantigene und schütten verschiedene Zytokine, die am proinflammatorischen Prozess beteiligt sind, aus. Aufbauend auf diesen Ergebnissen wurden in den letzten Jahren Therapien entwickelt, die gezielt B-Lymphozyten ansteuern um direkt oder indirekt in den autoimmunen Krankheitsverlauf einzugreifen. Die zeitlich begrenzte B-Zell-Depletion mit Rituximab (anti CD20-Antikörper) hat dabei in den letzten Jahren einen hohen Stellenwert erlangt und wird im klin
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10

Lazarus, Rajeka. "Memory B-cell responses to pneumococcal polysaccharide and conjugate vaccines in adults." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.549609.

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11

Centuori, Sara M., Cecil J. Gomes, Samuel S. Kim, et al. "Double-negative (CD27−IgD−) B cells are expanded in NSCLC and inversely correlate with affinity-matured B cell populations." BIOMED CENTRAL LTD, 2018. http://hdl.handle.net/10150/627195.

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Background: The presence of B cells in early stage non-small cell lung cancer (NSCLC) is associated with longer survival, however, the role these cells play in the generation and maintenance of anti-tumor immunity is unclear. B cells differentiate into a variety of subsets with differing characteristics and functions. To date, there is limited information on the specific B cell subsets found within NSCLC. To better understand the composition of the B cell populations found in NSCLC we have begun characterizing B cells in lung tumors and have detected a population of B cells that are CD79A(+)CD
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12

Zabel, Franziska [Verfasser]. "Primary and memory B cell responses to Qβ-VLP in mice / Franziska Zabel". Konstanz : Bibliothek der Universität Konstanz, 2014. http://d-nb.info/1112604049/34.

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13

Thompson, Rebecca. "Polyreactive and antigen-specific B-cell response to Streptococcus pneumoniae." University of Toledo Health Science Campus / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=mco1334150627.

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14

Nakamura, Masakazu. "Differential effects of fingolimod on B-cell populations in multiple sclerosis." Kyoto University, 2014. http://hdl.handle.net/2433/193543.

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15

Nicholas, Matilda Wray Clarke Stephen H. "A unique memory B cell subset correlates with adverse outomes [sic] in human SLE." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1249.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.
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16

Blanchard, Rohner Géraldine. "Persistence of protection against invasive bacteria : memory B cell responses in infants after immunisation." Thesis, University of Oxford, 2008. https://ora.ox.ac.uk/objects/uuid:328b5ab7-6dbd-48fb-b5e6-b682c060753a.

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Rapid waning of antibody and vaccine effectiveness is observed following infant immunisation with protein-polysaccharide conjugate vaccines. This is despite the demonstrable presence of immunological memory. However, disease can develop within a few days of carriage acquisition of encapsulated bacteria. Persistence of functional antibody, therefore, appears to be the key determinant of long-term protection against invasive bacterial diseases. Antibody persistence is thought to depend on the survival of long-lived plasma cells and memory B cells generated in germinal centres (GC). Using the ELI
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17

Abduh, Maisa. "Follicular CD4 T Cells Tutor CD8 Early Memory Precursors : an Initiatory Journey to the Frontier of B Cell Territory." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS371.

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Les lymphocytes T CD8+ spécifiques de l'antigène sont impliqués dans la réponse immunitaire adaptative et jouent un rôle essentiel dans la protection de l'hôte contre l'infection par des pathogènes intracellulaires. Cette protection de longue durée dépend de la génération de réponses lymphocytaires T CD8+ mémoires, hautement fonctionnelles en termes de fréquence et de fonctionnalité, après réinfection.Après présentation de l'antigène, une cellule T CD8 naïve subit une forte expansion clonale, générant une population hétérogène de cellules activées qui est dominée, au sommet de l'expansion, par
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18

Giesecke, Claudia. "Molecular and phenotypic studies of human antigen-specific effector- and memory B cells." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17394.

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Gedächtnis-B-Zellen und Plasmazellen sind essentielle Komponenten der protektiven Immunität. Die Mechanismen ihrer Induktion, ihres Überlebens und der Gedächtnis-B-Zellreaktivierung sind allerding bisher nur unvollständig verstanden. Um unser Wissen diesbezüglich zu erweitern, wurden in der vorliegenden Arbeit zum einen Charakteristika von Primär- und Sekundärimmunantworten nach Immunisierung mit Keyhole Limpet Hemocyanin (KLH) untersucht und zum anderen das Vorkommen sowie der Phänotyp humaner Gedächtnis-B-Zellen in verschiedenen lymphatischen Geweben analysiert. Die primäre parenterale KLH
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19

Buchauer, Lisa Franziska [Verfasser], and Thomas [Akademischer Betreuer] Höfer. "Heterogeneous Populations in B Cell Memory Responses and Glioblastoma Growth / Lisa Franziska Buchauer ; Betreuer: Thomas Höfer." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/117714977X/34.

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20

Buchauer, Lisa [Verfasser], and Thomas [Akademischer Betreuer] Höfer. "Heterogeneous Populations in B Cell Memory Responses and Glioblastoma Growth / Lisa Franziska Buchauer ; Betreuer: Thomas Höfer." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:16-heidok-255418.

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21

Jiang, Wei. "A Cross-sectional Study on the Effect of HIV Virion and Bacterial LPS on Memory B Cell Apoptosis." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1333674973.

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22

Rösel, Amelia L. [Verfasser]. "Classification of common variable immunodeficiencies using flow cytometry and memory B-cell functionality assay / Amelia L. Rösel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071087886/34.

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23

Le, Van Tuan. "Establishment of a memory B cell assay using recombinant Flavivirus protein for determinant of specific antiviral immunity." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-151733.

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Tick-borne encephalitis virus (TBEV) is a serious viral infection that affects the central nervous system. It was estimated that between 1990 and 2009 a total of 169,937 cases of TBE were recorded in Europe. TBEV belongs to genus Flavivirus that comprises over 70 viruses, many of them are important human pathogens. Most members are either transmitted by mosquitoes e.g. West Nile virus (WNV), Dengue virus (DENV) or ticks e.g. TBEV. Due to the extensive antigenic cross-reactivity among flaviviruses serological diagnosis of TBE infections is commonly difficult in areas where more than one virus t
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24

Rösel, Amelia [Verfasser]. "Classification of common variable immunodeficiencies using flow cytometry and memory B-cell functionality assay / Amelia L. Rösel." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1071087886/34.

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25

Atkinson, Jeffrey Ross. "Peripheral Germinal Centers Regulate Virus-Specific B Cell Accumulation in the CNS." Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1524683244217474.

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26

Murugan, Rajagopal [Verfasser], Hedda [Gutachter] Wardemann, Arturo [Gutachter] Zychlinsky, and Anja [Gutachter] Hauser. "Protective memory B cell response in controlled human malaria infection / Rajagopal Murugan ; Gutachter: Hedda Wardemann, Arturo Zychlinsky, Anja Hauser." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1182541283/34.

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27

Corti, Davide. "Analysis of the human B cell memory repertoire against infectious pathogens and isolation of broadly neutralizing human monoclonal antibodies /." Bern : [s.n.], 2008. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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28

Murugan, Rajagopal [Verfasser], Hedda Gutachter] Wardemann, Arturo [Gutachter] [Zychlinsky, and Anja [Gutachter] Hauser. "Protective memory B cell response in controlled human malaria infection / Rajagopal Murugan ; Gutachter: Hedda Wardemann, Arturo Zychlinsky, Anja Hauser." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1182541283/34.

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29

De, Milito Angelo. "Immune activation during HIV-1 infection : implication for B cell dysfunctions and therapy monitoring /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-170-5.

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30

Lúcia, Pérez Marc. "Assessment of human cytomegalovirus (HCMV)- specific memory T and B-cell responses as predictors of HCMV infection after kidney transplantion." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/293894.

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Despite the outstanding progress made in the understanding of the immune response against viral pathogens as well as on the care-management of transplant patients since the beginning of organ transplantation, hCMV infection still represents a major adverse complication among solid organ and hematopoietic cell transplant patients directly threatening both allograft and patient survival. While the advent of new and more potent anti-viral therapies used either as anti-viral treatments during active infection or as part of a preventive strategy, has lead to a significant reduction of the incide
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31

Aliprandini, Eduardo. "Obtenção de anticorpos monoclonais humanos antitetânicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-04122015-141425/.

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Anticorpos monoclonais (AcMos) para uso terapêutico correspondem a uma área importante na indústria de biofármacos, em especial os AcMos humanos, que apresentam menor probabilidade de elicitar imunogenicidade. O objetivo deste trabalho consistiu em obter AcMos humanos antitetânicos através da separação de linfócitos B produtores de anticorpos específicos utilizando o antígeno ou de plasmablastos. As células foram coletadas de doadores após vacinação e separadas por equipamento de cell sorter. As regiões variáveis dos anticorpos foram amplificadas e clonadas em vetores de expressão, que foram u
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32

Mei, Henrik Eckhard. "Analysen zur differentiellen Plasmazellhomöostase beim Menschen." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16048.

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Das humorale Immungedächtnis wird von reifen Plasmazellen des Knochenmarks vermittelt, welche bei Immunreaktionen aus aktivierten B-Lymphozyten gebildet werden. Dabei sind im Blut Plasmablasten als unmittelbare Vorläufer der Plasmazellen nachweisbar, die von dort aus in das Knochenmark einwandern. Anhand der durchflusszytometrischen Detektion spezifischer Plasmablasten gelang es hier, das simultane Auftauchen von Wellen neu generierter, migratorischer Plasmablasten und reifer, nicht-migratorischer Plasmazellen im Blut eine Woche nach einer Tetanusimpfung nachzuweisen. Plasmablasten und Plasma
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33

Nihei, Jorge Sadao. "Estudo da migração de células T NK1.1+ no músculo estriado, durante a infecção experímental pelo Trypanosoma Cruzi em animais desprovidos de linfócitos B funcionais." reponame:Repositório Institucional da FIOCRUZ, 2005. https://www.arca.fiocruz.br/handle/icict/5907.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-11-29T20:46:26Z No. of bitstreams: 1 Jorge Sadao Nihei Estudo da migracao... 2005.pdf: 58998863 bytes, checksum: 723e59711f41bac163f89f23858f2c34 (MD5)<br>Made available in DSpace on 2012-11-29T20:46:26Z (GMT). No. of bitstreams: 1 Jorge Sadao Nihei Estudo da migracao... 2005.pdf: 58998863 bytes, checksum: 723e59711f41bac163f89f23858f2c34 (MD5) Previous issue date: 2005<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>Foi anteriormente demonstrado que as células NK (Natural Ki
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34

Blanc, Pascal. "Expression et fonction du récepteur antigénique B membranaire sur les plasmocytes médullaires producteurs d'IgM." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10026/document.

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Le plasmocyte (PC), stade terminal de la différenciation du lymphocyte B induite par l'antigène, est la cellule effectrice de l'immunité humorale responsable de la production des anticorps. La population plasmocytaire se divise en deux grands sous-types différant par leur durée de vie et par leur localisation anatomique. On distingue ainsi les PC à durée de vie courte ou PC effecteurs (dans les tissus lymphoïdes secondaires) et les PC à longue durée de vi (LLPC ou PC à mémoire) localisés principalement dans la moelle osseuse. Ces derniers contribuent à la mémoire humorale en continuant à sécré
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35

Le, Van Tuan [Verfasser], Uwe Gerd [Akademischer Betreuer] Liebert, and Uwe Gerd [Gutachter] Liebert. "Establishment of a memory B cell assay using recombinant Flavivirus protein for determinant of specific antiviral immunity / Tuan Le Van ; Gutachter: Uwe Gerd Liebert ; Betreuer: Uwe Gerd Liebert." Leipzig : Universitätsbibliothek Leipzig, 2014. http://d-nb.info/1238789307/34.

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36

Rosário, Ana Paula Freitas do. "Análise dos compartimentos de linfócitos T e B de memória em animais tratados e não tratados com cloroquina durante a infecção pelo Plasmodium chabaudi AS." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-03062008-155929/.

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A exposição limitada ao Plasmodium chabaudi induz proeminente imunidade celular, associada à proteção de células T da apoptose. Este estudo tem como objetivo verificar a influência da carga parasitária na geração e manutenção dos linfócitos T e B de memória ao P. chabaudi. Assim, camundongos C57BL/6 foram submetidos à infecção tratada (subpatente) ou não (patente) com cloroquina após a inoculação de 106 eritrócitos parasitados (EP) e analisados nos dias 0, 20, 60, 120 e 200. Com relação à memória de linfócitos T, no dia 20, as freqüências de células CD4+ memória/ativadas e respondedoras aos EP
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Maho, Maud. "Evaluation des effets des traitements par Rituximab versus corticothérapie seule sur la réponse auto-réactive des patients atteints de pemphigus. First-line Rituximab combined with short-term Prednisone versus Prednisone alone for the treatment of Pemphigus (RITUX 3) : a prospective, multicentre, parallel-group, open-label randomised trial Risk factors for short-term relapse in patients with pemphigus treated by Rituximab as first-line therapy Rituximab and corticosteroid effect on Desmoglein specific B cells and T follicular helper cells in patients with Pemphigus Modifications or the transcriptomic profile of autoreactive B cells from pemphigus patients after treatment with Rituximab or standard corticosteroid regimen Long-term increase of Kcnn4 potassium channel surface expression on B cells in pemphigus patients after Rituximab treatment Rituximab is an effective treatment in patients with Pemphigus Vulgaris and demonstrates a steroid-sparing effect Modifications of the BAFF/BAFF-Receptor axis in patients with pemphigus treated with rituximab versus standard corticosteroids regimen. CD11C+ B cells are mainly memory cells prone to differentiate into antibody-secreting cells." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR132.

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Le pemphigus est une maladie auto-immune spécifique de la peau et des muqueuses provoqué par des auto-anticorps (Ac) spécifiques des desmogléines (Dsg) 1 ou 3. Ces Ac pathogéniques inhibent l'adhésion cellulaire des kératinocytes. Le pemphigus se déclenche par la conjonction d’événements rares impliquant l’émergence puis la coopération de lymphocytes B (LB) et de lymphocytes LT auto-réactifs dans un contexte génétique et environnemental particulier. Jusqu’à présent, la première ligne de traitement du pemphigus était constituée de fortes doses de corticoïdes, qui sont de puissants immunosupress
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Mohamed, Ahmed. "Deciphering the ontogeny of unmutated and mutated subsets of Chronic Lymphocytic Leukemia." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17286.

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Chronic Lymphocytic Leukemia (CLL) is a type of cancer that affects the B cells of the immune system causing problems in the process of producing antibodies. It can be sorted into mutated and unmutated CLL based on the percentage of somatic mutations in the Immunoglobulin Heavy chain Variable region (IgHV). The B cells of healthy individuals can be sorted into three groups; CD27dull memory B cells (MBCs), CD27bright MBCs and naïve B cells. The hypothesis for the project was that the unmutated CLL subset originates from CD27dull MBCs and the mutated CLL subset originates from CD27bright MBCs. R
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39

Rollenske, Tim. "Humans naturally acquire cross-specific anti-glycan antibodies." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18518.

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Bakterielle Glykanantigene sind hoch-divers in ihrer Komposition und Verbindung. Antikörper gegen Glykanantigene können vor bakteriellen Infektionen schützen und sind wichtig um die Homöostase zwischen dem Wirt und seinem Mikrobiom aufrecht zu halten. Typischerweise lösen Glykanantigene jedoch Antikörperantworten aus, die sich durch ein vermindertes B Zell-Gedächtnis und niedrig-affine Antikörper mit geringer Spezifität auszeichnen. In dieser Arbeit konnten, mithilfe von biotinylierten Lipopolysaccharide O-Antigenen des opportunistisch-pathogenen Bakteriums Klebsiella pneumoniae (Kp), O-Antige
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40

Comerma, Blesa Laura 1983. "Identification and characterization of a novel population of memory B cells in the human intestine." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/586327.

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We found that IgM+IgD- memory (ME-M) B cells formed a large reservoir of intestinal antigen-selected IgM+ lymphocytes distinct from antigen-naïve IgM+ lymphocytes. Human ME-M B cells colonized the intestine early in life, persisted throughout adulthood and inhabited Peyer’s patches and isolated lymphoid follicles. Intestinal ME-M B cells shared some commonalities with splenic IgM+IgDlowCD27+ marginal zone B cells, including phenotypic traits, multiple IgVH gene families and a pronounced reactivity against microbial carbohydrates and lipids. However, ME-M B cells expressed a gut-specific gene s
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41

Bannard, Oliver Michael. "The memory functions of CD8⁺ T cells that have expressed granzyme B." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611596.

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42

Addo, Richard Kwasi [Verfasser]. "Bone marrow maintains isotype switched memory B cells in stromal niches / Richard Kwasi Addo." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1212435192/34.

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Ishikawa, Yuki. "Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/IL-2Rγ-/- mice". Kyoto University, 2015. http://hdl.handle.net/2433/195963.

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Reiche, Sven, Yamen Dwai, Bianca M. Bussmann, Susanne Horn, Michael Sieg, and Christian Jassoy. "High inter-individual diversity of point mutations, insertions, and deletions in human influenza virus nucleoprotein-specific memory B cells." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-172324.

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The diversity of virus-specific antibodies and of B cells among different individuals is unknown. Using single-cell cloning of antibody genes, we generated recombinant human monoclonal antibodies from influenza nucleoprotein-specific memory B cells in four adult humans with and without preceding influenza vaccination. We examined the diversity of the antibody repertoires and found that NP-specific B cells used numerous immunoglobulin genes. The heavy chains (HCs) originated from 26 and the kappa light chains (LCs) from 19 different germ line genes. Matching HC and LC chains gave rise to 43 gen
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Zacharias, Zeb Ralph. "Induction and maintenance of diverse humoral and cellular immune responses following influenza A virus infection and vaccination." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6669.

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Influenza A virus (IAV) is a major cause of serious respiratory illness worldwide, leading to approximately 5 million severe cases and 500,000 deaths per year. Given the disease severity, associated economic costs, and recent appearance of novel IAV strains, there is a renewed interest in developing novel and efficacious “universal” IAV vaccination strategies as well as therapeutic remedies. Previous studies from our laboratory have concentrated on IAV-specific CD8 T cell-mediated protection against IAV infection as IAV-specific CD8 T cells are needed for efficient clearance of virus. Recent s
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MADRY, CHRISTINE. "La proteine bcma (b cell maturation) est un nouveau membre de la famille des recepteurs au tnf implique dans l'homeostasie de la population lymphocytaire b." Paris 7, 2000. http://www.theses.fr/2000PA077142.

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Le gene bcma (b cell maturation), isole apres analyse moleculaire d'une translocation t(4 ; 16) specifique d'un lymphome t intestinal, est exprime de facon preferentielle dans les lymphocytes b matures. Il code une proteine de 184 acides amines localisee dans une structure perinucleaire. Nous avons realise le clonage d'un adnc bcma murin afin d'obtenir des informations sur le role biologique de la proteine. La comparaison des sequences proteiques bcma humaine et murine revele la conservation de six cysteines dans le domaine terminal. La technique hca (high cluster analysis) indique que ces res
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Giesecke, Claudia [Verfasser], Andreas [Akademischer Betreuer] Radbruch, Thomas [Akademischer Betreuer] Dörner, and Kai [Akademischer Betreuer] Matuschewski. "Molecular and phenotypic studies of human antigen-specific effector- and memory B cells / Claudia Giesecke. Gutachter: Andreas Radbruch ; Thomas Dörner ; Kai Matuschewski." Berlin : Lebenswissenschaftliche Fakultät, 2015. http://d-nb.info/1081211245/34.

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Mahmood, Zafar [Verfasser], Hans-Peter [Gutachter] Tony, Thomas [Gutachter] Hünig, and Ingolf [Gutachter] Berberich. "Effect of cytokine inhibition on peripheral memory B cells in patients with Rheumatoid arthtritis / Zafar Mahmood. Gutachter: Hans-Peter Tony ; Thomas Hünig ; Ingolf Berberich." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1112040390/34.

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Soares, Roberta Reis. "Estudo fenotípico e funcional de populações de células B de memória durante a fase aguda e convalescença de malária vivax em pacientes expostos na Amazônia Brasileira." Universidade Federal de Juiz de Fora (UFJF), 2017. https://repositorio.ufjf.br/jspui/handle/ufjf/5694.

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Snanoudj, Renaud. "Lymphocytes B mémoire dans la réponse humorale anti-­HLA en transplantation d'organe." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00919770.

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Les alloanticorps anti-HLA sont dirigés vis-à-vis de différents épitopes des molécules du système HLA. Cette immunisation survient lors d'une transplantation d'organe, de transfusions sanguines ou d'une grossesse. On retrouve aussi ces anticorps, lorsque les techniques de détection sont sensibles, en l'absence de tout évènement immunisant. En transplantation d'organe, rénale en particulier, la présence d'anticorps anti-HLA, du fait des lésions de rejet humoral qu'ils induisent, constitue une des premières causes de perte de fonction des greffons à moyen et long terme. Néanmoins, les cellules l
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