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Dissertations / Theses on the topic 'B cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Carnathan, Diane Gail Vilen Barbara J. "Dendritic cell regulation of B cells." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1200.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Department of Microbiology and Immunology, School of Medicine." Discipline: Microbiology and Immunology; Department/School: Medicine.

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2

Crawford, A. "How B cells influence T cell responses." Thesis, University of Edinburgh, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.645118.

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Although studies using B cell deficient mice have been useful in understanding the importance of B cells under different conditions, it is difficult to then dissect exactly how B cells could be regulating T cell responses. By transferring OT-II transgenic T cells into either B cell deficient (μMT) or C57BL/6 mice, expansion and contraction of T cells can be tracked <i>ex vivo. </i>Expansion of OT-II cells is reduced in μMT mice compared to C57BL/6 mice. Thus, B cells can provide costimulatory signals, secrete cytokines and influence the lymphoid microarchitecture. To dissect which B cell facto

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3

Memon, Azka. "The function of CD180 toll like receptor(TLR) on control B cells and B cell chronic lymphocytic leukaemia (B-CLL) cells." Thesis, University of Westminster, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507859.

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4

Snell, Daniel C. "Cell-surface molecules of developing chicken B cells." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326977.

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5

Mahajan, Simmi. "Development of T cell help for B cells." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/12548.

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6

Ke, Chyan Ying. "Nanoscale antigen organization regulates binding to specific B-cells and B-cell activation." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/97825.

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Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, February 2015.<br>Cataloged from PDF version of thesis. "February 2015."<br>Includes bibliographical references.<br>The successes of vaccines in modern medicine diminished the morbidity and mortality of many pathogenic infections. Yet, difficulties remain in improving the immunogenicity of modern subunit vaccines. In addition, isolation of antigen-specific memory B cells that would elucidate the long-term efficacy of vaccines beyond using antibody titers as surrogates has been challenging due to the lack of specific and sen

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7

Jo, Tomoyasu. "LUBAC accelerates B-cell lymphomagenesis by conferring B cells resistance to genotoxic stress." Kyoto University, 2020. http://hdl.handle.net/2433/259010.

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8

Kobert, Antonia. "CNS-resident cells support MS-relevant B-cell responses." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114274.

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The therapeutic success of peripheral B-cell depletion strategies in MS patients has identified B cells as important contributors to new relapsing disease activity in the periphery. However, they may also drive the CNS-compartmentalized inflammatory processes thought to underlie the chronic-progressive stages of disease. The long-term persistence of plasma cells in the CNS of MS patients, and cellular aggregates rich in B cells, T cells and FDC-like cells that have recently been identified in the meningeal compartment, suggest the inflamed MS CNS may be a B-cell fostering environment. The fact

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9

Bansal, Raj Rani. "B cell help provided by human γδ T cells". Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/36649/.

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Vγ9Vδ2 T cells are a minor subset of T cells in human blood that differ from all other lymphocytes by their specific responsiveness to (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), a metabolite produced by a large range of microbial pathogens. Vγ9Vδ2 T cells can be skewed towards distinct effector functions, in analogy to, and beyond, the emerging plasticity of CD4+ T cells. Depending on the microenvironment, Vγ9Vδ2 T cells can assume features reminiscent of Th1, Th2, Th17 and Treg cells as well as professional antigen presenting cells (APCs). The main focus of this PhD was to inve

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10

Crawford, Alison. "Role of B cells in influencing T cell responses." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/13483.

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11

Chen, Hui-Chen. "Role for cyclic adenosine monophosphate (cAMP) response element binding proteins in B lymphocyte development and functional maturation." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1061213266.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 19.

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12

Kavikondala, Sushma. "Dendritic cell and B cell interactions in systemic lupuserythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39793710.

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13

Mühle, Kerstin. "Interaction of CD8+CD40L+ T cells with B cells." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19127.

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ZTLs vermitteln die Eliminierung von infizierten und entarteten Zellen durch Apoptose. Neuste Erkenntnisse unserer Gruppe haben gezeigt, dass eine Subpopulation der CD8+ T-Zellen, anstelle der zytotoxischen Marker das Oberflächenmolekül CD40L exprimiert. Die Expression von CD40L ist bislang als Schlüsselmolekül für die CD4+ T-Zell vermittelte Hilfe bekannt, welche durch Bindung an den CD40 Rezeptor auf anderen Immunzellen induziert wird. Das von den CD4+ T–Zellen ausgehende CD40L Signal ist besonders für die T-Zell abhängige B-Zell Aktivierung und die Bildung von Keimzentren essentiell, in den

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14

Lee, Michael Hweemoon. "Modulators of Dendritic Cells and B cells in Lupus." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/565007.

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Microbiology and Immunology<br>Ph.D.<br>Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies directed against ubiquitous self-antigens, many of which are nuclear autoantigens like dsDNA and chromatin (Pisetsky, 2016), and by elevated type I interferons (IFN) (Hooks et al., 1979; Weckerle et al., 2011), a family of pro-inflammatory cytokines that have antiviral activity (Pestka et al., 2004). Microarray analysis of peripheral blood mononuclear cells (PBMC) from SLE patients discovered the increased expression of IFN-responsive genes that

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15

Gao, Yuanyuan. "Studies on CD40 Signaling-Unpreventable B Cell Receptor-Mediated Apoptosis in T Cell-Dependent Bystander B Cells." 京都大学 (Kyoto University), 2012. http://hdl.handle.net/2433/157848.

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16

Almond, Jason Baron. "Mechanisms of proteasome inhibitor-induced apoptosis of B-cell chronic lymphocytic leukaemia (B-CLL) cells." Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/30761.

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Proteasome inhibitors, including lactacystin, LLnL (N-acetyl-N-leucinyl-L-leucinyl-L- norleucinal) and MG132 (carbobenzoxyl-leucinyl-leucinyl-leucinal), potently induce apoptosis in leukaemic B-cells from patients with B-cell chronic lymphocytic leukaemia (B-CLL). This pro-apoptotic effect occurs in cells from patients at all stages of the disease, including those resistant to conventional chemotherapy, suggesting that proteasome inhibitors may be useful for treatment of B-CLL. Following initial inhibition of proteasomal activity and an increase in ubiquitinated proteins, these agents induce m

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17

Aboalela, Ali Anwar. "Immune Reconstitution of B Cells Following Allogeneic Hematopoietic Cell Transplantation." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17331949.

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Objectives: Graft versus host disease (GVHD), infections and disease relapse continue to be major complications of allogeneic hematopoietic cell transplantation (HCT). B cell abnormalities have been associated with these complications, and the objective of these studies was to identify and quantify abnormalities of B cell recovery after allogeneic HCT. Methods: Flow cytometry was used to analyze peripheral blood from healthy donors (HD) and samples obtained at 1, 2, 3, 6, 9, 12, 18, 24, 30, and 36 months post HCT. A panel of 8 fluorophore-conjugated monoclonal antibodies specific for B cell su

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18

Philips, Julia Rachel. "B-1 and B-2 B cell responses to lipopolysaccharide: Putative roles in the pathogenesis of periodontitis." Thesis, The University of Sydney, 2003. http://hdl.handle.net/2123/1852.

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Periodontal disease is one of the most widespread diseases in humans and is characterised by chronic gingival inflammation and B cell accumulation and resorption of the crest of alveolar bone with subsequent loss of teeth. Porphyromonas gingivalis has been identified as a putative aetiological agent for periodontitis. The aim of the research presented in this thesis was to investigate, using in vitro systems, the responses of autoreactive B-1 and B-2 cells to enterobacterial and nonenterobacterial lipopolysaccharide (LPS) to shed light on the pathogenesis of chronic periodontitis and other dis

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19

Kavikondala, Sushma. "Dendritic cell and B cell interactions in systemic lupus erythematosus." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39711523.

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20

Centuori, Sara M., Cecil J. Gomes, Samuel S. Kim, et al. "Double-negative (CD27−IgD−) B cells are expanded in NSCLC and inversely correlate with affinity-matured B cell populations." BIOMED CENTRAL LTD, 2018. http://hdl.handle.net/10150/627195.

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Background: The presence of B cells in early stage non-small cell lung cancer (NSCLC) is associated with longer survival, however, the role these cells play in the generation and maintenance of anti-tumor immunity is unclear. B cells differentiate into a variety of subsets with differing characteristics and functions. To date, there is limited information on the specific B cell subsets found within NSCLC. To better understand the composition of the B cell populations found in NSCLC we have begun characterizing B cells in lung tumors and have detected a population of B cells that are CD79A(+)CD

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21

Fichtner, Michael Verfasser], and Martin [Akademischer Betreuer] [Trepel. "Identification of B cell antigen receptor epitopes of mantle cell lymphoma B cells / Michael Fichtner ; Betreuer: Martin Trepel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://nbn-resolving.de/urn:nbn:de:gbv:18-81789.

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22

Fichtner, Michael [Verfasser], and Martin [Akademischer Betreuer] Trepel. "Identification of B cell antigen receptor epitopes of mantle cell lymphoma B cells / Michael Fichtner ; Betreuer: Martin Trepel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2016. http://d-nb.info/1119319889/34.

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23

Lemoine, François Michel. "Studies of the interactions between stromal cells and B lymphoid progenitors." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28856.

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The overall goal of the work, described in this thesis was to investigate the molecular mechanisms that regulate normal pre-B cell proliferation and how these may be altered in transformed pre-B cells. Monoclonal antibodies and molecular biological techniques have allowed a number of stages of pre-B cell differentiation to be defined but little is known about mechanisms controlling their proliferation. Studies of pre-B cell production in animal models and in long-term cultures that support pre-B cell proliferation have suggested that stromal cells play a key role in this regard. As a first st

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24

Tun, Paul Fei-Tun. "BAFF, B cells and tumour immunity." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534210.

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25

O'Brien, Charlotte Rose. "B cells, Bach2 and immune deficiency." Thesis, Imperial College London, 2017. http://hdl.handle.net/10044/1/58936.

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B cell defects in HIV-1 infection are characterised by increased frequency of immature cell subsets, loss of memory cells, and hypergammaglobulinemia. There is increasing evidence that the capacity of B cells to secrete cytokines (IL-10) or express proteins (Bach2), may inhibit the T cell inflammatory response, which is believed to contribute to progressive immune deficiency in HIV-1. The aims were to determine if HIV-1 affects the capacity of B cells to express IL-10, TNF-α, and Bach2, and if alterations in cytokines and Bach2 expression were linked to T cell activation. An increase in immatu

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26

Lambert, David G. "Insulin release from cultured B-cells." Thesis, Aston University, 1987. http://publications.aston.ac.uk/14520/.

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Established RlNm5F and lN111 R1 and newly available HlT-T15 and UMR 407/3 B-cell lines have been successfully maintained in vitro. With the exclusion of UMR 407/3 cells, all lines were continuously propagable. Doubling times and plating efficiencies for HlT-T15, RlNm5F, lN111 R1 and UMR 407/3 cells were 20 hours and 85%, 31 hours and 76%, 24 hours and 80% and 38 hours and 94% respectively. All the cell lines were anchorage dependent, but only UMR 407/3 cells grew to confluence. Only HlT-T15 and UMR 407/3 cells produced a true insulin response to glucose but glucose markedly increased the rate

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27

Liu, Jing. "Regulation of VH replacement in human immature B cells by B cell receptor (BCR)-mediated signaling." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010p/liu.pdf.

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28

Blink, Elizabeth J. "B cell selection in the germinal centre /." Connect to thesis, 2002. http://eprints.unimelb.edu.au/archive/00001459.

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29

Mosti, Laura [Verfasser], and Anton [Akademischer Betreuer] Cathomen. "Generation of safe CAR T cells to target B cell malignancies." Freiburg : Universität, 2021. http://d-nb.info/1232174378/34.

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30

Philips, Julia Rachel. "B-1 And B-2 B Cell Responses To Lipopolysaccharide: Putative Roles In The Pathogenesis Of Periodontitis." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/4395.

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Master of Science<br>Periodontal disease is one of the most widespread diseases in humans and is characterised by chronic gingival inflammation and B cell accumulation and resorption of the crest of alveolar bone with subsequent loss of teeth. Porphyromonas gingivalis has been identified as a putative aetiological agent for periodontitis. The aim of the research presented in this thesis was to investigate, using in vitro systems, the responses of autoreactive B-1 and B-2 cells to enterobacterial and nonenterobacterial lipopolysaccharide (LPS) to shed light on the pathogenesis of chronic period

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31

Philips, Julia Rachel. "B-1 and B-2 B cell responses to lipopolysaccharide putative roles in the pathogenesis of periodontitis /." University of Sydney, 2006. http://hdl.handle.net/2123/1852.

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Master of Science<br>Periodontal disease is one of the most widespread diseases in humans and is characterised by chronic gingival inflammation and B cell accumulation and resorption of the crest of alveolar bone with subsequent loss of teeth. Porphyromonas gingivalis has been identified as a putative aetiological agent for periodontitis. The aim of the research presented in this thesis was to investigate, using in vitro systems, the responses of autoreactive B-1 and B-2 cells to enterobacterial and nonenterobacterial lipopolysaccharide (LPS) to shed light on the pathogenesis of chronic period

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32

Feldhahn, Niklas. "Mimicry of a constitutively active pre-B cell receptor in BCR-ABL1-transformed pre-B leukemia cells." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=979851769.

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33

Le, Thuc-vy L. "B cell clonal abundance and madcam-1 mediate affinity maturation and fate of germinal center B cells." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/le.pdf.

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34

Otero, Dennis C. "CD19 affects B-cell lymphopoiesis at multiple stages influencing survival, proliferation and differentiation of developing B-cells /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3022214.

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35

Chan, Kwok-hung, and 陳國雄. "Epstein-Barr virus mediated B lymphocyte transformation and B cell ontogeny." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31234100.

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36

Chan, Kwok-hung. "Epstein-Barr virus mediated B lymphocyte transformation and B cell ontogeny /." Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17391143.

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37

Bashford-Rogers, Rachael Jennifer Mary. "Analysing the B-cell repertoire : investigating B-cell population dynamics in health and disease." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708880.

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38

Zao, Chih-Ling. "B Virus Circumvents Innate Responses in Human Cells." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_diss/41.

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B virus (Cercopithecine herpesvirus 1) is an alphaherpesvirus indigenous to macaque monkeys and is closely related to herpes simplex virus type 1 (HSV-1). Disease caused by B virus, which is often mild or asymptomatic in its natural host, the macaque monkey, is similar in infected macaques to HSV-1 infection in humans. When B virus zoonotically infects foreign hosts, e.g., humans, high morbidity and mortality are evidenced in > 80% of untreated cases. To explore the underlying reasons for differences in pathogenesis between B virus and HSV-1 infection in humans, human microarrays were used to

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39

Hartweger, H. "The function of Themis2 in B cells." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1460492/.

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Thymocyte-expressed molecule involved in selection 2 (Themis2) is the second member of the Themis family. Recently, the first member of the Themis family, Themis, has been reported to be part of the TCR signalling cascade and its deletion severely affects thymocyte progression from the double positive to the single positive stage. All family members share similar domains and high sequence similarity and show tissue specific expression with Themis2 being expressed in B lymphocytes, macrophages and dendritic cells. THEMIS2 associates with BCR signalling molecules such as GRB2, VAV or LYN and is

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40

Oliver-Bell, Jessica. "The role of B cells in periodontitis." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6464/.

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Introduction: Varying degrees of periodontal disease affect the majority of the population. Severe forms of periodontitis have a considerable impact on oral health and quality of life. Periodontitis results from imbalances in the oral microbiome and the host immune response. The mainstay of periodontal treatment – removal of dental plaque – is only partially successful. B cells infiltrate the gingiva of periodontitis patients, but their role in pathology has not been well characterised. The overarching aim of this research was to better characterise the role of B cells in periodontitis. Period

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41

Kumari, Anita. "Mechanics of antigen extraction by B cells." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB037/document.

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Les lymphocytes B sont un des éléments essentiels de l’immunité adaptative de par leur fonction de production d’anticorps. In vivo, leur activation est principalement déclenchée par l’engagement de leur récepteur BCR (B cell receptor) associé à des antigènes présents à la surface des cellules voisines. Cette interaction conduit à la formation d'une synapse immunitaire qui coordonne les événements de réorganisation de la signalisation et du cytosquelette qui sont essentiels pour l’extraction et le traitement des antigènes par les lymphocytes B. Deux modèles ont été proposés pour l'extraction d’

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42

Berti, Alvise. "Autoreactive B Cells in ANCA-Associated Vasculitis." Doctoral thesis, Università degli studi di Trento, 2021. http://hdl.handle.net/11572/325394.

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Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of B-cell driven, autoimmune systemic vasculitides characterized by a relapsing course and the presence of ANCA autoantibodies which are instrumental in their pathogenesis. We aimed to investigate autoreactive proteinase 3 (PR3+) B cells involved in the development of human AAV. We previously developed a customized flow-cytometry method to identify autoreactive B cells among cryopreserved peripheral blood mononuclear cells (PBMC), using labeled PR3, one of the main AAV autoantigens, as a ligand. We therefore use

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43

郑健 and Jian Zheng. "Generation of human allo-antigen specific CD4+ and CD8+ regulatory T cells with CD40-activated B cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46922969.

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44

Guy, Thomas Victor. "The roles of CD4 T cells and B cells in antitumour immunity." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15427.

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There have been great advances in clinical immunotherapies against cancer over the past two decades. Most recently, immunotherapies directed against immuno-inhibitory molecules such as CTLA4 and PD1 have led to major therapeutic breakthroughs, rapidly becoming an integral part of clinical practice. Yet we still lack complete understanding of how these therapies work, how to increase their efficacy, and how to limit their often life-threatening side effects. Furthermore, we lack comprehensive understanding of the immune landscape in cancer. Antitumour responses incorporate a large number of cel

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45

Piperno, Nicolas. "Role of autocrine IL-13 producing B cells in plasma cell development." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40762.

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Recent studies have determined that IgE-producing B lymphocytes are present in the respiratory mucosa of patients with asthma and rhinitis, but not in respiratory mucosa of normal individuals. Our laboratory has shown that B lymphocytes in human nasal mucosa stain strongly for interleukin 13 (IL-13), a crucial cytokine for airway hyper-responsiveness and remodelling, and that inhibiting IL-13 decreases IgE secretion significantly in B cells. We sought to determine the role of IL-13 in sustaining IgE-producing B lymphocytes in the absence of a lymph node-like environment. Human B lymphocytes w

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46

Ekici, Rifat. "B cells in Type 1 diabetes : studies on cell surface antibody binding." Licentiate thesis, Umeå universitet, Immunologi/immunkemi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37376.

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47

Bergamin, Fabio. "Antigen-presenting cells and BAFF in porcine B-cell responses against FMDV /." Bern : [s.n.], 2007. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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48

Hine, Dominic William. "B cells as antigen-presenting cells in a model of rheumatoid arthritis." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2189.

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Rheumatoid arthritis (RA) is a multifaceted inflammatory autoimmune disease characterised by the infiltration of leukocytes into synovial joints leading to the destruction of articular cartilage and bone. Autoreactive CD4+ T cells producing inflammatory cytokines are implicated in disease pathogenesis. The clinical efficacy of B cell-depletion therapy is not dependent on clearance of autoantibodies suggesting a critical role for B cells as antigen presenting cells (APC). To elucidate the role of B cells in activating CD4+ T cells in RA, this project examined B cell- mediated antigen presentati

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49

Scuderi, Richard. "G1-phase cyclin expression in neoplastic B cells /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-292-2/.

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50

Velez, Maria-Gabriela. "Development and function of allelically included B cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 153-162). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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