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Dissertations / Theses on the topic 'B-CLL'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Schlaak, Max Simon. "Differentielles Genexpressionsmuster in chronischen lymphatischen Leukämiezellen vom B-Zell-Typ (B-CLL-Zellen)." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=966320069.

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2

Schlaak, Max Simon. "Differentielles Genexpressionsmuster in chronischen lymphatischen Leukämiezellen vom B-Zell-Typ (B-CLL-Zellen)." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/14817.

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Die B-CLL ist eine niedrigmaligne Erkrankung, die im höheren Lebensalter auftritt und für die es weiterhin keine dauerhaft kurative Therapie gibt. Die Erforschung der genetischen Grundlagen dieser Krankheit könnte Erkenntnisse über die Funktionsmechanismen und neue Diagnose- und Therapieansätze erbringen. Ziel dieser Arbeit war es, eine Genbank von CLL-Patienten bzw. gesunden Spendern zu erstellen, um Gene, die für die Entstehung der Erkrankung mitverantwortlich sein könnten, zu identifizieren. Die subtraktive suppressive Hybridisierung (SSH) wurde als Methode eingesetzt, um cDNA-Mischungen z

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3

Kurzeder, Christian. "Gentransfer in primäre B-CLL-Zellen mittels EBV abgeleiteter Genvektoren." [S.l.] : [s.n.], 2004. http://edoc.ub.uni-muenchen.de/archive/00004955.

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4

Kurzeder, Christian. "Gentransfer in primäre B-CLL-Zellen mittels EBV abgeleiteter Genvektoren." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-49552.

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5

Bund, Dagmar. "hTERT, CD23 und CD229 als Tumorantigene bei der B-CLL." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-145282.

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6

Almond, Jason Baron. "Mechanisms of proteasome inhibitor-induced apoptosis of B-cell chronic lymphocytic leukaemia (B-CLL) cells." Thesis, University of Leicester, 2002. http://hdl.handle.net/2381/30761.

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Proteasome inhibitors, including lactacystin, LLnL (N-acetyl-N-leucinyl-L-leucinyl-L- norleucinal) and MG132 (carbobenzoxyl-leucinyl-leucinyl-leucinal), potently induce apoptosis in leukaemic B-cells from patients with B-cell chronic lymphocytic leukaemia (B-CLL). This pro-apoptotic effect occurs in cells from patients at all stages of the disease, including those resistant to conventional chemotherapy, suggesting that proteasome inhibitors may be useful for treatment of B-CLL. Following initial inhibition of proteasomal activity and an increase in ubiquitinated proteins, these agents induce m

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7

Walton, Alexander James. "CD4+PF+ T Cells in B-CLL Patients & Normal Controls." Thesis, University of Westminster, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502405.

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Our group has previously shown that CD4+Perforin (PFt T cells with cytotoxic potential are expanded in patients with B-CLL, accounting for up to 50% of CD4+ T cells in this disease. This study confinns the finding of increased percentages of CD4+PF+ T cells in a new cohort of B-CLL patients. However, the significance of this subset in B-CLL remains unclear. Evidence has accumulated for the potential role of CD4+ cytotoxic T cells in controlling cytomegalovirus (CMV). Therefore, a potential relationship between chronic CMV infection and CD4+PF+ T cell expansion in B-CLL was investigated. CMV se

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8

Munoz-Ritchie, Varinia Graciela. "P-glycoprotein-associated anthracycline resistance in B-CLL : potential for cytokine modulation." Thesis, University of Plymouth, 2001. http://hdl.handle.net/10026.1/2809.

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The phenomenon of multidrug resistance (MDR) in cancer cells is generally associated with P-glycoprotein (P-gp) expression and presents an obstacle to successful chemotherapy. Attempts to overcome P-gp-associated MDR using P-gp modulators, such as verapamil, have been hindered by their intrinsic in vivo toxicity. In 1991, however, Scala et al. demonstrated the alteration of P-gp function by interferon-alpha (IFN-α) in vitro at non-toxic in vivo concentrations, suggesting a basis for the use of IFN-α clinically in patients exhibiting P-gp-associated MDR. Drug resistance in B-CLL has been linked

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9

Hellqvist, Eva. "Antigen interaction with B cells in two proliferative disorders : CLL and MGUS." Doctoral thesis, Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2010. http://www2.bibl.liu.se/liupubl/disp/disp2010/med1158s.pdf.

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10

Gorgone, Ausilia Giuseppa. "Correlazione tra dati biologici e prognosi in pazieti affetti da B-CLL." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1138.

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Gli studi di questi anni hanno dimostrato che i fattori biologici giocano un ruolo fondamentale per la stratificazione del rischio come elementi predittivi del treatment-free survival e dell' overall survival nei pazienti affetti da CLL in stadio iniziale.La maggioranza di questi markers prognostici ,anche se ormai in uso quotidiano nella pratica clinica, non è ancora incluso nelle linee guida internazionali che si basano ancora su criteri esclusivamente clinici e individuano la valutazione biologica da usare in combinazione ai parametri clinici.Il loro impiego può certamente contribuire al m

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11

Memon, Azka. "The function of CD180 toll like receptor(TLR) on control B cells and B cell chronic lymphocytic leukaemia (B-CLL) cells." Thesis, University of Westminster, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.507859.

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12

Hellebrand, Eva. "Entwicklung von GM-CSF-produzierenden EBV-Vektoren für die Immuntherapie der B-CLL." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-12575.

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13

Niu, Suli. "Quantitative Determination of Surface Markers on B-cell Chronic Lymphocytic Leukemia (CLL) Cells." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30982.

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To supplement and modify the diagnosis and clinical research of B-cell Chronic Lymphocytic Leukemia (B-CLL), a new method based on cell imaging and image processing was developed and applied to the B-CLL patient samples. The fluorophore-labelled leukemia cells were clearly visualized, reflecting the positive/negative expression of the corresponding surface markers and their distribution. Computer algorithms were devised and used to analyze a large number of images. The fluorescence intensity of the labelled antibodies on a given cell directly reflects the expression of the corresponding surfac

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14

McWilliams, Emily Mary. "Restoring Innate NK-cell Immunity with Antibody Therapeutics in CLL B-Cell Malignancy." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479863842166353.

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15

Kiaii, Shahryar. "T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-050-3/.

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16

Abdulmajed, Hind Abdulrazak Yassin. "Identification of tumour associated antigens as potential targets for the immunotherapy of B-cell chronic lymphocytic leukaemia (B-CLL)." Thesis, University of Leicester, 2008. http://hdl.handle.net/2381/9157.

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B-CLL, the most common adult B-cell malignancy in USA and the western world, is characterized by the accumulation of CD5+ mature B-cells in blood, bone marrow and lymphoid tissues. Many cases require no treatment because of an indolent course, while other patients become symptomatic or develop signs of rapid progression. Treatment is usually non-curative and is directed at reducing the symptoms. However, new therapies are currently under investigation aiming to achieve a curative therapy for B-CLL. The increasing understanding of how peptide antigens are processed, transported and presented by

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17

Osorio, Fernández Lyda María. "Regulation of T-cell proliferation and B-CLL apoptosis by CD6 and FAS/FASL /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980605osor.

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18

Ferrario, A. "THE CLINICAL AND BIOLOGICAL FEATURES OF A SERIES OF IMMUNOPHENOTYPIC VARIANT OF B-CLL." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/203768.

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We described the clinical and biological features of 63 cases of immunophenotypic variant of B-CLL (v-CLL) characterised by intermediate RMH score, in absence of t(11;14)(q13;q32) in FISH analysis in comparison with 130 cases of typical CLL. We observed significant differences in terms of age <70 yrs (p <.001), lymphocytosis <20 x 109/l (p <.001), lymphocyte doubling time <12 months (p = .02), high serum beta2-microglobulin levels (p <.001) and splenomegaly (p = .002); CD38, CD49d, CD1c were more expressed in v-CLL, CD43 in CLL (p <.001). IgVH mutation and trisomy 12 were more frequent in v

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19

Jordanova, Maya. "Veränderungen von B-Zellantigenen unter Rituximab-Therapie." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15121.

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Das FMC7-Antigen, eine unbekannte B-Zell-Membranstruktur, dient als eines der immunphänotypischen Grundkriterien zur Diagnose der typischen B-CLL. Die unterschiedliche CD20-Expressionsintensität ist auch ein charakteristisches Merkmal bei der Subtypisierung der Lymphomentitäten. In der vorliegenden Arbeit wurde die Modulation des CD20- und des FMC7-Antigens während einer Therapie mit CD20-Antikörper (Rituximab) bei Patienten mit indolenten B-Zell-Lymphomen untersucht. Bei der durchflusszytometrischen Untersuchung quantitativer und qualitativer Charakteristika der monoklonalen B-Zell-Population

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20

Gu, Baijun. "TWO PATHWAYS OF SHEDDING OF L-SELECTIN AND CD23 FROM HUMAN B-LYMPHOCYTES." University of Sydney, 2000. http://hdl.handle.net/2123/821.

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Lymphocytes from patients with B-chronic lymphocytic leukemia (B-CLL) express large numbers of P2X7 receptors for extracellular adenosine triphosphate (ATP). Activation of P2X7 receptors induces multiple downstream effects, of which the best documented is the opening of an ionic channel that is selective for divalent cations. Another effect of ATP is to induce the shedding of L-selectin (CD62L), a molecule which is involved in the adhesive interactions of lymphocytes on endothelial cells. High levels of soluble L-selectin and CD23 are found in the serum of patients with B-CLL, although the

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21

Rezvany, Mohammad Reza. "Natural specific T cell immunity in patients with B-cell chronic lymphocytic leukaemia (B-CLL) : (a clinical and immunological study) /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4841-0/.

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22

Trimarco, Valentina. "Role of Nocodazole on the survival of chronic lymphocytic leukemia B cells." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422967.

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B-cell Chronic Lymphocytic Leukemia (B-CLL) is the most common leukemia in adults and is characterized by the accumulation of clonal CD19+/CD5+/CD23+ B lymphocytes, due to uncontrolled growth and resistance to apoptosis. Leukemic cells from B-CLL show reduced crosslink with specific molecules and high susceptibility to microtubule disrupting drugs, which suggest cytoskeletal alterations. Microtubules play a crucial role in the vital functions of neoplastic cells, including mitosis, motility and cell-cell contact, and for this reason they became an important target in cancer therapies. In pa

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23

Rossmann, Eva D. "Targets for immune mediated killing of tumor cells and T cell functions in B-CLL /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-622-7/.

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24

Bund, Dagmar [Verfasser], and Michael [Akademischer Betreuer] Hallek. "hTERT, CD23 und CD229 als Tumorantigene bei der B-CLL / Dagmar Bund. Betreuer: Michael Hallek." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1024243443/34.

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25

Dein, Thomas [Verfasser], and Martin [Akademischer Betreuer] Trepel. "Untersuchungen zur Interaktion von CLL B-Zell-Rezeptoren mit Autoantigenen / Thomas Dein. Betreuer: Martin Trepel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1048626407/34.

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26

Nothing, Maria Grazia [Verfasser]. "Lenalidomid in der B-CLL: direkte Effekte auf die Tumorzelle in vitro / Maria Grazia Nothing." Ulm : Universität Ulm, 2016. http://d-nb.info/1112603077/34.

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27

Dai, Yuntao. "CHARACTERIZATION OF TCL1-MURINE B-1A CELL TRANSCRIPTOME DYNAMICS REVEALS NOVEL INSIGHTS INTO CHRONIC LYMPHOCYTIC LEUKEMIA ONSET." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1434632288.

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28

Schlaak, Max Simon [Verfasser], F. [Gutachter] Schriever, J. [Gutachter] Klose, and U. [Gutachter] Keilholz. "Differentielles Genexpressionsmuster in chronischen lymphatischen Leukämiezellen vom B-Zell-Typ (B-CLL-Zellen) / Max Simon Schlaak ; Gutachter: F. Schriever, J. Klose, U. Keilholz." Berlin : Humboldt-Universität zu Berlin, 2003. http://d-nb.info/1207658294/34.

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29

Nardini, Elena. "Characterization of genetic events involving IgH switch regions in gastric low grade MALT lymphomas and B CLL." Thesis, Open University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251405.

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30

Mohamed, Ahmed. "Deciphering the ontogeny of unmutated and mutated subsets of Chronic Lymphocytic Leukemia." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17286.

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Chronic Lymphocytic Leukemia (CLL) is a type of cancer that affects the B cells of the immune system causing problems in the process of producing antibodies. It can be sorted into mutated and unmutated CLL based on the percentage of somatic mutations in the Immunoglobulin Heavy chain Variable region (IgHV). The B cells of healthy individuals can be sorted into three groups; CD27dull memory B cells (MBCs), CD27bright MBCs and naïve B cells. The hypothesis for the project was that the unmutated CLL subset originates from CD27dull MBCs and the mutated CLL subset originates from CD27bright MBCs. R

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31

Blanco, Ares Gonzalo 1989. "Molecular characterization of the microenvironment in CLL-like monoclonal B cell lymphocytosis and early-stage chronic lymphocytic leukemia." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664506.

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The analysis of the microenvironment in CLL-like monoclonal B cell lymphocytosis (MBL) and early-stage chronic lymphocytic leukemia (CLL) is relevant for understanding the natural history of CLL. To this end, a total of 58 MBL, 54 early-stage CLL and 31 healthy subjects were extensively characterized by various immunological and molecular methods. Purified CD4+ and CD8+ mononuclear cells from peripheral blood were subjected to gene expression studies and T cell receptor (TR) repertoire analysis, whereas cytokine immunoassays were performed in serum samples. Gene expression studies in CD4+ cell

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32

Rawluk, Justyna. "Untersuchungen zur Signaltransduktion des CXCR4-(CD-184)-Chemokinrezeptors im Hinblick auf Vitalität und Migration humaner B-CLL-Zellen." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972879765.

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33

Talab, Fatima. "Identification of LCK as a key mediator of B cell receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL)." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/14973/.

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Chronic lymphocytic leukaemia (CLL) is a common type of adult leukaemia that accounts for approximately 30% of all mature B-lymphocyte malignancies. An important contributor to CLL pathogenesis is B-cell receptor (BCR) signalling which promotes survival of the malignant clone. BCR engagement on CLL cells provides survival signals by activating the NFκB pathway. Previous work to this thesis showed that CLL cells overexpress PKC-betaII and c-Abl, kinases which have been implicated in mediating NF-kappaB pathway activation in normal B cells. In particular, PKC-beta mediates activation of the CAR

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34

Müller, David Johannes [Verfasser]. "Charakterisierung des B-Zell-Rezeptors (BCR) auf NFAT2-deletierten CLL-Zellen im Eµ-TCL1-Mausmodell / David Johannes Müller." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1217249230/34.

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35

Abbaci, Amazigh. "Caractérisation fonctionnelle du récepteur de type 2 de la neurotensine dans la résistance à la mort cellulaire des lymphocytes B au cours de la Leucémie Lymphoïde Chronique." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0029/document.

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La leucémie lymphoïde chronique (LLC) est caractérisée par une accumulation anormale de lymphocytes B matures. Les thérapies actuelles reposent sur l'utilisation d'inhibiteurs ciblant les kinases impliquées dans la voie du récepteur des cellules B (BCR), mais elles sont limitées par le niveau élevé de résistance à l’apoptose des cellules leucémiques. En effet, celles-ci échouent à éradiquer les cellules résistantes à l'apoptose, il est donc essentiel d'identifier d'autres voies de survie comme nouvelles cibles pour les thérapies anticancéreuses. La surexpression des récepteurs de surface coupl

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36

Auchter, Morgan. "Implication de la topoisomérase IIIa dans la stabilité chromosomique au cours de la recombinaison télomérique des cellules cancéreuses." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4008.

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Dans les cellules somatiques, les télomères s'érodent à chaque division cellulaire. Ce processus appelé « Sénescence Réplicative» est contrebalancé de manière basale chez la levure bourgeonnante S. cerevisiae par l'action de la télomérase qui, alors qu'elle est inactive dans les cellules somatiques des eucaryotes supérieures, est activée dans 85% des cancers. Un autre mécanisme impliqué dans les 15% des cas de cancer restants et est appelé Alternative Lengthening of Telomere (ALT). Dans ce processus, le maintien des télomères est assuré par des mécanismes de recombinaison télomérique induisant

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37

Schönsteiner, Stefan [Verfasser]. "Analyse des B-Zell-Rezeptor-Rearrangements an Patienten der CLL-8 Studie: Assoziation mit Charakteristika und Überlebenszeiten / Stefan Schönsteiner." Ulm : Universität Ulm. Medizinische Fakultät, 2015. http://d-nb.info/1071629328/34.

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38

Stadler, Maike. "Die Wirkung des Chemokins "Pulmonary and activation-regulated chemokine" (PARC)auf B-CLL-Zellen und B-Zell-Linien, sowie Untersuchungen zur Expression und Signaltransduktion eines potentiellen PARC-Rezeptors." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-20100121-100623-7.

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Bis heute sind über 50 Chemokine und fast 20 Chemokinrezeptoren identifiziert. Dennoch gibt es Chemokine und Chemokinrezeptoren, deren zugehörige Rezeptoren bzw. Liganden noch nicht bekannt sind. PARC (=CCL18) ist ein ausschließlich in Primaten nachgewiesenes, bisher nur wenig charakterisiertes, im Organismus jedoch weit verbreitetes Chemokin, für das bisher noch kein Rezeptor beschrieben wurde. Die Wirkung dieses Chemokins wurde bisher vor allem an T Lymphozyten nachgewiesen. Die vorliegende Arbeit untersucht die Wirkung von PARC auf B-Lymphozyten und das Vorkommen des putativen PARC-Rezeptor

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39

Rajakaruna, A. V. Nadeeka P. "Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)." Thesis, University of Westminster, 2017. https://westminsterresearch.westminster.ac.uk/item/q254x/functional-interaction-between-cd180-toll-like-receptor-tlr-and-b-cell-receptor-bcr-in-the-biology-of-chronic-lymphocytic-leukaemia-cll.

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Chronic Lymphocytic Leukaemia (CLL) is the most common leukaemia in the western world and remains incurable. It is driven by as yet unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the microenvironment through a range of cytokines and receptors, including Toll-like receptors (TLR). The role of the microenvironment in the development and progression of CLL is currently of major interest. Pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) represent exogenous and endogenous microenvironmental factors a

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Culpin, Rachel Emily. "Expression of the MiR-17-92 cluster in DLBCL and B-CLL and its relationship with disease outcome and established prognostic factors." Thesis, University of Newcastle Upon Tyne, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582656.

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Diffuse large B-cell lymphoma is an aggressive malignancy of large transformed B- lymphocytes. The disease is biologically and clinically highly heterogeneous and this nature has impacted on patients response to treatment. Gene profiling studies have identified two biologically diverse sub-groups, that exhibit different prognoses, namely; the germinal centre (GC)- and activated B-cell (ABC)- like DLBCL. B-cell chronic lymphocytic leukemia is also a heterogeneous disease. Patients may follow an indolent clinical course and survive for >20 years, but others have a rapidly progressive disease req

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41

Ghosh, Anil Kumar. "The role of heat shock proteins, amyloid precursor protein and B-cell CLL/lymphoma 3 and their co-chaperones in colorectal cancer." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8392.

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The elevated expression of Heat shock proteins (HSPs) has been implicated in CRC prognosis and tumour cells may require the expression of HSPs and BCL2-associated athanogene (BAG1), the HSP co-chaperone, to survive. BAG1 is a regulator of amyloid precursor protein (APP); both are important in cellular proliferation and cancer. B-cell CLL/lymphoma 3 (BCL3) is an agonist in the tumour-associated NF-κB pathway. This study aims to establish the mutational status of TP53, KRAS and PIK3CA, and the activation status of AKT, in primary CRCs and then investigate the role of HSPs, BAG1, APP, and BCL3. O

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42

Lindqvist, Camilla. "T Regulatory Cells – Friends or Foes?" Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128837.

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T regulatory cells (Tregs) have been extensively studied in patients with cancer or autoimmunity. These cells hamper the immune system’s ability to clear tumor cells in cancer patients. In autoimmune diseases, on the other hand, they are not able to restrain autoreactive immune responses. If we manage to understand Tregs and their role in health and diseases we may be able to develop better immunomodulatory therapies. Early studies demonstrated that tolerance was maintained by a subset of CD25+ T-cells. CD25 was the earliest marker for Tregs and is still often used to define these cells. Sever

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43

CASTELLI, MONICA. "INCREASED SURVIVAL OF CLL B CELLS IN THE PRESENCE OF MARROW MESENCHYMAL STROMAL CELLS: A NOVEL MODEL TO DEFINE NEW TARGETS FOR THERAPY." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424459.

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Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the Western World, accounting for about 30% of adult leukemia, and it is characterized by the clonal expansion and accumulation of mature CD19+/CD5+/CD23+ B lymphocytes in the peripheral blood, bone marrow and secondary lymphoid organs. Despite their apparent longevity in patients, in vitro CLL leukemic B cells rapidly undergo spontaneous apoptosis. The selective survival advantage is due both to intrinsic defects on apoptosis mechanism and to signals delivered by accessory cells at the active site of the disease. Previous studi

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44

Rehman, Haroon, Asha Chepkorir Segie, Kanishka Chakraborty, and Devapiran Jaishankar. "Bone Marrow Wars: Attack of the Clones." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/33.

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Multiple myeloma is characterized by the malignant proliferation of clonal plasma cells producing monoclonal paraproteins, leading to multi-organ damage. On the other hand monoclonal B-cell lymphocytosis (MBCL) is characterized by the malignant proliferation of clonal B-lymphocytes, with potential to develop into chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). CLL/SLL can result in visceromegaly, anemia, thrombocytopenia, fevers, night sweats and unintentional weight loss. Literature review demonstrates these two malignant clonal bone marrow disorders are most frequentl

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Chiodin, Giorgia. "Chronic Lymphocytic Leukemia: analysis of microenvironmental influence on neoplastic clone survival and IgM signaling during Ibrutinib therapy." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422771.

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Chronic Lymphocytic Leukemia (CLL) is characterized by the monoclonal expansion of mature CD19+/CD5+/CD23+ B lymphocytes in peripheral blood, bone marrow and lymphoid tissues. Surface IgM (sIgM) signaling is key to CLL behavior and is a therapeutic target of the BTK-inhibitor Ibrutinib. SIgM levels and signaling capacity are variable in CLL and correlate with the behavior of the disease. In CLL, the microenvironment also plays an important role in disease support and progression. In this thesis two projects are presented: the analysis of the microenvironmental influence on neoplastic clone sur

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Pötzsch, Birgit [Verfasser]. "Die Bedeutung des Ang2-Tie2-Signalweges für die Interaktion von malignen B-Lymphozyten mit ihrer Mikroumgebung bei der chronischen lymphatischen Leukämie (CLL) / Birgit Pötzsch." Köln : Deutsche Zentralbibliothek für Medizin, 2014. http://d-nb.info/1056004169/34.

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Veuillen, Caroline. "Caractérisation des mécanismes d'échappement tumoral à la lyse NK dans la LLC-B et le cancer de la prostate." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20708.

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De nombreuses données expérimentales et cliniques ont montré l'importance des cellules Natural Killer (NK) dans l'immunosurveillance antitumorale. Les stratégies thérapeutiques basées sur les cellules NK pourraient donc être une alternative de choix dans le traitement de certains types de cancers. Nous avons focalisé notre étude sur deux types de cancer incurables malgré les récents progrès thérapeutiques : la leucémie lymphoïde chronique B (LLC-B) et le cancer de la prostate. Le but de notre étude est une meilleure compréhension des mécanismes mis en place par les cellules B leucémiques et le

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Hadife, Nader. "Interleukine-24 : rôle immunologique et mécanismes d'induction de mort cellulaire dans les lymphocytes B." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0018/document.

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Notre équipe a précédemment démontré que l'Interleukine (IL)-24 une cytokine de la famille de l'IL-10 a un effet cytostatique voire cytotoxique sur des cellules B normales ou leucémiques mises préalablement en cycle mais non sur des cellules quiescentes. L'IL-24 inhibe également la différenciation plasmocytaire des cellules B humaines du centre germinatif dans un modèle de différentiation in vitro. Nous avons utilisé ce modèle pour analyser pour la première fois le transcriptome de cellules B stimulées ou non par IL-24 au bout de 6 et 36 h. Plusieurs transcrits impliqués dans le métabolisme et

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Orlandi, Veronica. "Effects of p66shc expression on bioenergetics and cell viability of b-cell chronic lymphocytic leukemia." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3423953.

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During tumorigenesis many oncogenic pathways are reprogrammed and modulate mitochondrial metabolism, decreasing oxidative phosphorylation (OXPHOS) activity. They inhibit ATP synthesis and ROS production from OXPHOS complexes favoring metabolic switching toward a more glycolytic metabolism and tumor growth. This metabolic rewiring is well established in solid tumor but very little is known about this event in non-solid tumors such as leukemias. Indeed, it has been demonstrated that in chronic lymphocytic leukemia (B-CLL), cells show a high OXPHOS activity and elevated ROS levels. Notably, expre

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Lopes, Ana Alexandra Festas. "Estudo funcional das células T de gânglio normal/reativo e com doença linfoproliferativa crónica de células B." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16768.

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Mestrado em Bioquímica - Bioquímica Clínica<br>As doenças linfoproliferativas crónicas de células B são um grupo heterogéneo de entidades que representam cerca de 80-90% de todas as síndromes linfoproliferativas crónicas, nas quais podem ser observadas uma proliferação clonal de linfócitos B. Amostras de biópsia de gânglio linfático podem ser usadas para o diagnóstico destas doenças. Os gânglios linfáticos são o local adequado para as interações entre as células B e as células T e para ocorrer uma resposta imune. Neste sentido, é esperado que, na presença de células B malignas, com uma

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