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Dissertations / Theses on the topic 'B-LLA'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

CRICRÌ, GIULIA. "ActivinA as a key modulator of B-Cell Precursor Acute Lymphoblastic Leukemia Cell motility and vesiculation within the bone marrow niche." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/304789.

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La Leucemia Linfoblastica Acuta (LLA) è il tumore più frequente in età pediatrica. Nonostante l’alto successo terapeutico raggiunto, una percentuale di pazienti non risponde alle terapie convenzionali. Numerosi studi hanno mostrato come il microambiente midollare giochi un importante ruolo nella progressione tumorale. Il nostro scopo è stato quello di identificare i pahways cruciali coinvolti nel cross-talk tra le cellule leucemiche e il microambiente stromale e che possano essere dei potenziali target terapeutici. Abbiamo studiato AttivinaA, molecola della superfamiglia del TGF-β, all’interno

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Mohr, Audrey. "Caractérisation des lymphocytes B régulateurs dans la leucémie lymphoïde chronique." Thesis, Brest, 2016. http://www.theses.fr/2016BRES0066/document.

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Contexte: La leucémie lymphoïde chronique (LLC) est une hémopathie maligne associée à des anomalies dans les réponses immunitaires. Ce qui contribue à la progression de la maladie. Certains LB peuvent induire une inhibition de la réponse anti-tumorale des LT et ainsi promouvoir la progression des tumeurs. Ces LB appelés LB régulateurs partagent des caractéristiques communes avec les LB de LLC.Objectif: L'objectif principal de ce projet est d'évaluer la fonction régulatrice des LB de LLC, afin d’estimer leur influence sur l'absence de réponses anti-tumorales par les cellules T.Méthode: Des modè

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Zanin, Rafael Fernandes. "Hidrólise extracelular de ATP e ADP pela enzima NTPDase1 em linfócitos de pacientes com leucemia linfocítica crônica-B." Universidade Federal de Santa Maria, 2006. http://repositorio.ufsm.br/handle/1/11149.

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The NTPDase1 enzymatic activity (E.C.3.6.1.5, Apyrase, ecto-ATP-diphosphohydrolase, CD39) which hydrolyses ATP and ADP, was analyzed in peripheral lymphocytes from patients with B chronic lymphocytic leukemia (B-CLL) which the main characteristic is the accumulation of monoclonal mature B-lymphocyte. The sample was composed by 23 patients with B-CLL whose were diagnosed according to the clinical and laboratorial criteria and also by the immunophenotypic characteristics. The patients were divided, according to the Binet staging system, in 4 groups: stage A (early), stage B (intermediate), stage

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4

Rebelo, Sandra Sofia da Silva Ferreira. "Estudo por citogenética convencional e FISH de 50 amostras com LLC-B." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/844.

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Mestrado em Biologia Molecular e Celular<br>A leucemia linfocítica crónica do tipo B (LLC-B) é a forma de leucemia mais comum nos adultos do hemisfério Ocidental e, apesar de afectar sobretudo indivíduos idosos, cerca de um quinto dos pacientes tem menos de 55 anos quando diagnosticada. Esta patologia segue um decurso clínico variável com taxas de sobrevivência que se estendem de meses a décadas. Tem-se verificado uma evolução crescente no conhecimento e compreensão das doenças linfoproliferativas crónicas durante os últimos 30 anos, recorrendo a métodos citogenéticos, moleculares e imunológic

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5

Villamor, i. Casas Neus. "Activitat "natural killer" a la leucèmia limfàtica crònica de línia B." Doctoral thesis, Universitat de Barcelona, 1991. http://hdl.handle.net/10803/2319.

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Les cèl.lules "natural killer" (CNK) van ser descobertes a l'inici de la dècada de 1970 per la seva capacitat de lisar de forma espontània cèl.lules tumorals. Estudis realitzats posteriorment han posat de manifest que aquesta població cel.lular està continguda en els limfòcits grans granulats (LGG) de sang perifèrica (SP) i que poseeixen unes estructures de membrana característiques definides pel CD16 i CD56.<br/>La funció de les CNK dintre de l'organisme és molt àmplia. Controla el creixement i disseminació de cèl.lules tumorals i de cèl.lules infectades pel virus, regula el creixement de la

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6

Bras, Marlène. "Etude des mécanismes régulant la mort cellulaire indépendante des caspases médiée par CD47 dans la leucémie lymphoïde chronique B (LLC-B)." Paris 6, 2006. http://www.theses.fr/2006PA066240.

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Il arrive fréquemment que les lymphocytes B de Leucémie Lymphoïde Chronique B (LLC-B) présentent des anomalies qui les rendent résistantes à l’apoptose classique induite par les traitements chimiothérapeutiques. Dans ce contexte, nos résultats montrent que la stimulation de CD47 induit une nouvelle voie de mort cellulaire qui reste fonctionnelle dans les cellules B de LLC-B, alors même qu’elles se montrent résistantes à l’apoptose classique. Cette mort est caractérisée exclusivement par des altérations cytoplasmiques et notamment mitochondriales. Celles-ci ne sont pas couplées à un relargage d

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Moga, Naranjo M. Esther. "Potenciació de la citotoxicitat cel·lular induïda pel Rituximab en cèl·lules B de LLC." Doctoral thesis, Universitat Autònoma de Barcelona, 2008. http://hdl.handle.net/10803/3814.

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L'evolució clínica de la leucèmia limfocitària crònica (LLC) és amb freqüència indolent, però és una malaltia que roman incurable. Els pacients simptomàtics tenen una supervivència entre 1-7 anys, fins i tot utilitzant les millors opcions terapèutiques. Encara que han estat avaluades tot una sèrie de combinacions terapèutiques en pacients amb recaiguda o refractaris als tractaments, cap alternativa ha demostrat ser superior. Per tant, és evident la necessitat de trobar alternatives terapèutiques per aquests pacients. <br/>Diferents estudis en fase II han mostrat que l'associació del rituximab

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8

Ghamlouch, Hussein. "La différenciation des cellules B de la LLC en cellules sécrétrices d'anticorps : conséquences sur notre compréhension de la physiopathologie de la LLC." Amiens, 2014. http://www.theses.fr/2014AMIED002.

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Les cellules B sont des vecteurs importants de l'immunité humorale. Le plasmocyte ou cellule sécrétrice d’anticorps (CSA) est la cellule effectrice résultante de la différenciation terminale de la lignée B. Les cellules B de la leucémie lymphoïde chronique (LLC) ont été utilisées comme modèle pour étudier la différenciation des cellules B humaines. La leucémie lymphoïde chronique de type B est la leucémie la plus fréquente chez les adultes dans le monde occidental. Il s'agit d'une maladie hétérogène caractérisée par la prolifération clonale et l'accumulation de lymphocytes B matures CD5+. Le m

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9

Neiva, Luciana Barros de Moura. "Toxicidade da polimixina B em células LLC-PK1 e a enzima heme oxigenase-1." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-07052009-112206/.

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Na lesão renal aguda, os mecanismos de defesa atuam como genes protetores, como a proteína heat shock 32 (HSP 32), também conhecida como heme oxigenase-1 (HO-1). A polimixina B (PmxB) é um antimicrobiano nefrotóxico. O objetivo deste estudo foi caracterizar a participação da enzima HO-1 na toxicidade da PmxB em células LLC-PK1. As células foram submetidas aos seguintes tratamentos: Controle (CTL- 0µM); Hemin (indutor de HO-1, 25µM); Hemin II (250M), Protoporfirina de zinco (ZnPP - inibidor de HO-1, 10M,); Nitro-L-arginina-metilester (L-NAME - inibidor de iNOS, 0,1mM); PmxB (375µM); PmxB + Hemi

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Martínez, Lostao Luis. "STAT1 en la apoptosis inducida por fludarabina e inhibidores de Jak Kinasas en las celulas de LLC-B. Papel de las celulas adherentes en la apoptosis inducida por fludarabina." Doctoral thesis, Universitat Autònoma de Barcelona, 2004. http://hdl.handle.net/10803/3755.

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Auchter, Morgan. "Implication de la topoisomérase IIIa dans la stabilité chromosomique au cours de la recombinaison télomérique des cellules cancéreuses." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4008.

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Dans les cellules somatiques, les télomères s'érodent à chaque division cellulaire. Ce processus appelé « Sénescence Réplicative» est contrebalancé de manière basale chez la levure bourgeonnante S. cerevisiae par l'action de la télomérase qui, alors qu'elle est inactive dans les cellules somatiques des eucaryotes supérieures, est activée dans 85% des cancers. Un autre mécanisme impliqué dans les 15% des cas de cancer restants et est appelé Alternative Lengthening of Telomere (ALT). Dans ce processus, le maintien des télomères est assuré par des mécanismes de recombinaison télomérique induisant

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12

Pasero, Christine. "Expression et fonction de LIGHT et HVEM, membres de la superfamille des TNF/TNFR, sur les lymphocytes B normaux et leucémiques (LLC-B)." Aix-Marseille 2, 2007. http://www.theses.fr/2007AIX20667.

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Les membres de la superfamille des TNF/TNFR jouent un rôle important dans de nombreux processus biologiques, en participant à des réponses variées telles que la prolifération, l’organogenèse, l’apoptose ou l’inflammation. Au cours de ma thèse, nous avons pu évaluer l’expression et le rôle de HVEM, membre de la superfamille des TNFR, et son ligand LIGHT sur les lymphocytes B normaux et pathologiques. Ces travaux nous ont permis de mettre en évidence une coopération entre LIGHT et CD40L pour induire l’expression de LIGHT à la surface des lymphocytes B, ainsi que pour la prolifération de ces cell

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GRULOIS, ISABELLE. "Etude fonctionnelle du phenomene multidrogue resistance dans les lymphocytes normaux et dans les lymphocytes pathologiques de la llc-b." Rennes 1, 1992. http://www.theses.fr/1992REN1M139.

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14

Veuillen, Caroline. "Caractérisation des mécanismes d'échappement tumoral à la lyse NK dans la LLC-B et le cancer de la prostate." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20708.

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De nombreuses données expérimentales et cliniques ont montré l'importance des cellules Natural Killer (NK) dans l'immunosurveillance antitumorale. Les stratégies thérapeutiques basées sur les cellules NK pourraient donc être une alternative de choix dans le traitement de certains types de cancers. Nous avons focalisé notre étude sur deux types de cancer incurables malgré les récents progrès thérapeutiques : la leucémie lymphoïde chronique B (LLC-B) et le cancer de la prostate. Le but de notre étude est une meilleure compréhension des mécanismes mis en place par les cellules B leucémiques et le

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15

Blanco, Ares Gonzalo 1989. "Molecular characterization of the microenvironment in CLL-like monoclonal B cell lymphocytosis and early-stage chronic lymphocytic leukemia." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664506.

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The analysis of the microenvironment in CLL-like monoclonal B cell lymphocytosis (MBL) and early-stage chronic lymphocytic leukemia (CLL) is relevant for understanding the natural history of CLL. To this end, a total of 58 MBL, 54 early-stage CLL and 31 healthy subjects were extensively characterized by various immunological and molecular methods. Purified CD4+ and CD8+ mononuclear cells from peripheral blood were subjected to gene expression studies and T cell receptor (TR) repertoire analysis, whereas cytokine immunoassays were performed in serum samples. Gene expression studies in CD4+ cell

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Machado, RosÃngela Pinheiro GonÃalves. "Perfil clÃnico dos pacientes com LLC-B do AmbulatÃrio do Hospital UniversitÃrio Walter CantÃdio/HEMOCE: corelaÃÃo com marcadores biolÃgicos de prognÃstico." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4594.

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IntroduÃÃo: A Leucemia LinfocÃtica CrÃnica (LLC) Ã uma neoplasia caracterizada pela proliferaÃÃo clonal de linfÃcitos de aspecto maduro. Apresenta curso clÃnico e prognÃstico heterogÃneo. Rai e Binet criaram sistemas de prognÃsticos clÃnicos que classificam a LLC em baixo, intermediÃrio e alto risco. Surgiram os marcadores biolÃgicos de prognÃstico que aumentaram o poder preditivo na LLC. Objetivo:Caracterizar os marcadores clÃnicos e biolÃgicos de pognÃstico dos pacientes com LLC do ambulatÃrio do Hospital UniversitÃrio Walter CantÃdio (HUWC)/Centro de Hematologia e Hemoterapia do CearÃ/HEMO

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Masdehors, Peggy. "Mécanismes moléculaires et cellulaires de l'apoptose radio-induite dans les lymphocytes humains normaux et pathologiques (LLC-B) : implication du système ubiquitine." Paris 5, 2000. http://www.theses.fr/2000PA05P610.

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Machado, Rosângela Pinheiro Gonçalves. "Perfil clínico dos pacientes com LLC-B do Ambulatório do Hospital Universitário Walter Cantídio/Hemoce : corelação com marcadores biológicos de prognóstico." reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/1906.

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MACHADO, Rosângela Pinheiro Gonçalves. Perfil clínico dos pacientes com LLC do ambulatório do HUWC/HEMOCE : correlação com marcadores biológicos de prognóstico. 2009. 98 f. Dissertação (Mestrado em Patologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2009.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-01-02T12:51:43Z No. of bitstreams: 1 2009_dis_rpgmachado.pdf: 1773194 bytes, checksum: 675138583153cb1dc3b08c327efbb714 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-02-02T16:26:56Z (GMT) No. of bitstreams: 1

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Hadife, Nader. "Interleukine-24 : rôle immunologique et mécanismes d'induction de mort cellulaire dans les lymphocytes B." Thesis, Université de Lorraine, 2013. http://www.theses.fr/2013LORR0018/document.

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Notre équipe a précédemment démontré que l'Interleukine (IL)-24 une cytokine de la famille de l'IL-10 a un effet cytostatique voire cytotoxique sur des cellules B normales ou leucémiques mises préalablement en cycle mais non sur des cellules quiescentes. L'IL-24 inhibe également la différenciation plasmocytaire des cellules B humaines du centre germinatif dans un modèle de différentiation in vitro. Nous avons utilisé ce modèle pour analyser pour la première fois le transcriptome de cellules B stimulées ou non par IL-24 au bout de 6 et 36 h. Plusieurs transcrits impliqués dans le métabolisme et

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Lopes, Ana Alexandra Festas. "Estudo funcional das células T de gânglio normal/reativo e com doença linfoproliferativa crónica de células B." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/16768.

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Mestrado em Bioquímica - Bioquímica Clínica<br>As doenças linfoproliferativas crónicas de células B são um grupo heterogéneo de entidades que representam cerca de 80-90% de todas as síndromes linfoproliferativas crónicas, nas quais podem ser observadas uma proliferação clonal de linfócitos B. Amostras de biópsia de gânglio linfático podem ser usadas para o diagnóstico destas doenças. Os gânglios linfáticos são o local adequado para as interações entre as células B e as células T e para ocorrer uma resposta imune. Neste sentido, é esperado que, na presença de células B malignas, com uma

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França, Flavia Dayrell. "Avaliação do envolvimento da via de sinalização PKA na nefrotoxicidade causada pela Anfotericina B e Ciclosporina utilizando linhagens celulares LLC-PK1 e MDCK." Universidade Federal de Minas Gerais, 2013. http://hdl.handle.net/1843/BUBD-9DKFMN.

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Amphotericin B (antifungal) and Cyclosporine (immunosuppressant) are commonly used drugs in medical clinics; however, these often present Nephrotoxicity. The proposal of the present study was to evaluate the involvement of the cellular PKA signaling pathway on Nephrotoxicity caused by Amphotericin B and Cyclosporine using renal cell lines: LLC-PK1 (proximal tubules of pigs) and MDCK (distal tubules of dogs). To accomplish this goal, the present study evaluated parameters involved in Nephrotoxicity, such as cytotoxicity (Neutral Red and MTT), cell death (Flow Cytometry), the recovery of toxic e

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Silva, Flávia Amoroso Matos e. "Estudo do compartimento de linfócitos T CD4+ em pacientes com LLC-B: distribuição das subpopulações TH1, TH2, TH17 e TREG e avaliação da expressão de FAS e FASL." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-24022015-082206/.

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LLC-B é uma neoplasia hematológica derivada de uma população de linfócitos B maduros CD5+ localizados na zona do manto dos folículos linfóides e é a mais comum das doenças linfoproliferativas. É uma doença clinicamente heterogênea na qual certos pacientes apresentam quadros indolentes que durante muitos anos podem ser controlados com pouco ou nenhum tratamento. Relatos da literatura sugerem que os linfócitos T na LLC-B podem ser incapazes de iniciar, manter e concluir uma resposta imune para a célula B maligna e outros antígenos, e podem estar diretamente envolvidos na manutenção do tumor. Os

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Chiarelli, Maria Catarina Silveira. "Perfil clínico-laboratorial e associação com fatores prognósticos de pacientes com leucemia linfocítica crônica." Universidade Federal de Santa Maria, 2012. http://repositorio.ufsm.br/handle/1/5964.

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Chronic Lymphocytic Leukemia is the primary lymphoid neoplasm in adults and and it is especially manifested in the elderly. Because it is a heterogeneous disease it awakens great interest regarding its prognosis. Rai and Binet developed staging systems to predict the evolution of the disease and currently, the analysis of expression of CD38 and Zap-70 has been investigated as a prognostic factor for indicating presence or absence of the mutation in the gene IgVH, so, the objective of this study was to analyze the clinical and laboratory profiles of patients with Chronic Lymphocytic Leuke

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Oliveira, Mariana Lobato de 1991. "Determining the prognostic significance of PI3K/Akt/mTOR and JAK/STAT5 signaling pathways in pediatric acute lymphoblastic leukemia using single-cell analysis." Master's thesis, 2015. http://hdl.handle.net/10451/23456.

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Tese de mestrado, Oncobiologia, Faculdade de Medicina, Universidade de Lisboa, 2015<br>Acute lymphoblastic leukemia (ALL) is the most frequent childhood malignancy and it is characterized by the accumulation of immature lymphoid cells within the bone marrow and lymphoid tissues. Approximately 85% of pediatric ALL patients have a B-cell phenotype (B-ALL), and, despite significant improvements in treatment outcome, around 10-20% still relapse. Thus, there is a clear need for new prognostic factors capable of accurately predicting response to therapy. PI3K/Akt/mTOR and JAK/STAT5 pathways are ext

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Valença, Catarina de Jesus Mesquita. "Nova abordagem técnica no estudo citogenético da leucemia linfocítica crónica-B." Master's thesis, 2018. http://hdl.handle.net/10348/9117.

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Dissertação de Mestrado em Biotecnologia para as Ciências da Saúde apresentada à Universidade de Trás-os-Montes e Alto Douro<br>A leucemia linfocítica crónica B (LLC-B) é a forma de leucemia mais prevalente no hemisfério Ocidental, afetando sobretudo indivíduos adultos, com idade superior a 65 anos. É uma doença clonal linfoproliferativa, caracterizada pela proliferação anormal e acumulação de linfócitos B neoplásicos nos tecidos sanguíneos, órgãos linfáticos e medula óssea. A análise citogenética desempenha um papel muito importante no estudo desta patologia, uma vez que a deteção de alteraçõ

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Lin, Kuan-Hua, and 林冠華. "Advanced glycation end-product-induced effects are dependent on glycogen synthase kinase-3b/b-catenin pathway in LLC-PK1 cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/77046539078788659704.

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博士<br>高雄醫學大學<br>醫學研究所<br>96<br>Diabetic nephropathy is the complication of diabetes mellitus. In Taiwan, diabetes mellitus and end-stage renal disease is the 5th and 8th leading cause of death, respectively. Diabetic nephropathy is a major cause of morbidity and mortality, which comprise of 20-40% of the diabetic patients. The pathogenesis of diabetic nephropathy is characterized by the proliferation of mesangial cells in the early stage but hypertrophy of renal cell at the late stage of diabetes mellitus. Moreover, the thickening of glomerular basement membrane and the accumulation of extrace

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Piranishvili, Giorgi [Verfasser]. "Flavor physics: neutrinoproduction of resonances and semileptonic B → K, K* ll decays / vorgelegt von Giorgi Piranishvili." 2008. http://d-nb.info/997470194/34.

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Gopee, Neera Vintra. "Involvement of sphingoid bases and their metabolites in fumonisin B₁-induced alterations in protein kinase C-mediated signaling in LLC-PK₁ cells." 2002. http://purl.galileo.usg.edu/uga%5Fetd/gopee%5Fneera%5Fv%5F200212%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2002.<br>Directed by Raghubir P. Sharma. Includes articles submitted to Journal of biological chemistry, Biochemistry, Toxicological Sciences, and Toxicology. Includes bibliographical references.

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Rentz, Sarah Suzanne. "The role of fumonisin B¹ and other inhibitors of de novo sphingolipid biosynthesis in the expression of p42 MAP kinase (pERK2) in LLC-PK₁ cells." 2002. http://purl.galileo.usg.edu/uga%5Fetd/rentz%5Fsarah%5Fs%5F200205%5Fms.

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Thesis (M.S.)--University of Georgia, 2002.<br>Directed by Ronald Riley. Includes an article submitted to Toxicology & applied pharmacology. For abstract see http://getd.galib.uga.edu/public/rentz_sarah_s_200205_ms/rentz_sarah_s_200205_ms.pdf. Includes bibliographical references.

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