Academic literature on the topic 'B-Lymphocytes Cell Lineage Granulocytes Myeloid Cells Receptors'

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Journal articles on the topic "B-Lymphocytes Cell Lineage Granulocytes Myeloid Cells Receptors"

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Wognum, AW, TP Visser, MO de Jong, T. Egeland, and G. Wagemaker. "Differential expression of receptors for interleukin-3 on subsets of CD34-expressing hematopoietic cells of rhesus monkeys." Blood 86, no. 2 (1995): 581–91. http://dx.doi.org/10.1182/blood.v86.2.581.bloodjournal862581.

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The target cell specificity of interleukin-3 (IL-3) was examined by flow cytometric analysis of IL-3 receptor (IL-3R) expression on rhesus monkey bone marrow (BM) cells using biotinylated IL-3. Only 2% to 5% of unfractionated cells stained specifically with the biotinylated IL-3 and most of these cells were present within the CD34+ subset. IL-3Rs were detected on small CD34dull/RhLA-DRbright/CD10+/CD27+/CD2-/++ +CD20- cells, which probably represent B-cell precursors. IL-3R+ CD34- BM cells, which were detected at low frequencies, consisted of small CD20dull/surface-IgM+/RhLA-DR+ cells. These c
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Hultquist, Anne, Robert Mansson, Mikael Sigvardsson, et al. "Genetic Evidence of a Novel Blood Differentiation Pathway from Lympho-Myeloid Hematopoietic Stem/Progenitor Cells, Independent of Common Myeloid Progenitors." Blood 104, no. 11 (2004): 1696. http://dx.doi.org/10.1182/blood.v104.11.1696.1696.

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Abstract We have recently identified three novel subsets of multipotent hematopoietic stem/progenitor cells (HSCs) in the Lin−Sca-1+c-Kithi (LSK) compartment of adult murine bone marrow based on differential expression of CD34 and the cytokine tyrosine kinase receptor Flt3. Long-term HSCs (LT-HSCs) lack CD34 and Flt3 expression (LSKCD34-flt3-), whereas short-term HSCs (ST-HSCs) are LSKCD34+flt3−. A third LSK population is characterized by co-expression of CD34 and Flt3 (LSKCD34+flt3+) and possess a combined myeloid (granulocyte and monocyte) and lymphoid (B and T cell) differentiation potentia
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Pospisil, Vitek, Emanuel Necas, and Tomas Stopka. "PU.1 Activity Determines Fate of Myeloid Progenitor Cells during Lineage Commitment." Blood 108, no. 11 (2006): 4207. http://dx.doi.org/10.1182/blood.v108.11.4207.4207.

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Abstract Myeloid cell commitment is regulated by factors interacting with chromatin in a progenitor cell entering differentiation. PU.1 is an ETS family transcription factor that has been well characterized in inducing myelopoiesis and blocking erythroid differentiation. Conditionally activated PU.1-Estrogen Receptor transgene in mouse PU.1 knockout-derived hematopoietic progenitors is known to induce macrophage differentiation. We observed that manipulation of PU.1 activity by using different levels of PU.1-ER activator, tamoxifen, was capable of producing major populations of myeloid progeny
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Till, KJ, J. Burthem, A. Lopez, and JC Cawley. "Granulocyte-macrophage colony-stimulating factor receptor: stage- specific expression and function on late B cells." Blood 88, no. 2 (1996): 479–86. http://dx.doi.org/10.1182/blood.v88.2.479.bloodjournal882479.

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Granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors (GMR) are expressed on myeloid cells throughout their maturational sequence. During myelopoiesis, GM-CSF induces the proliferation of precursors and has multiple effects on more mature cells; such effects include induction of maturation and priming for subsequent stimulation. GMR is expressed on a range of other cell types including acute leukemic blasts of myeloid and lymphoid lineage, but has been little studied on more mature lymphoid cells. Using sensitive triple-layer immunophenotypic techniques, we show here that both th
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Kubagawa, Hiromi, Ching-Cheng Chen, Le Hong Ho, et al. "Biochemical Nature and Cellular Distribution of the Paired Immunoglobulin-like Receptors, PIR-A and PIR-B." Journal of Experimental Medicine 189, no. 2 (1999): 309–18. http://dx.doi.org/10.1084/jem.189.2.309.

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PIR-A and PIR-B, paired immunoglobulin-like receptors encoded, respectively, by multiple Pira genes and a single Pirb gene in mice, are relatives of the human natural killer (NK) and Fc receptors. Monoclonal and polyclonal antibodies produced against a recombinant PIR protein identified cell surface glycoproteins of ∼85 and ∼120 kD on B cells, granulocytes, and macrophages. A disulfide-linked homodimer associated with the cell surface PIR molecules was identified as the Fc receptor common γ (FcRγc) chain. Whereas PIR-B fibroblast transfectants expressed cell surface molecules of ∼120 kD, PIR-A
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Dahl, Richard, Sangeeta R. Iyer, and M. Celeste Simon. "E47 Binds to PU.1 Inhibiting Its Ability To Bind DNA and Activate Gene Expression." Blood 104, no. 11 (2004): 1609. http://dx.doi.org/10.1182/blood.v104.11.1609.1609.

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Abstract The transciption factor PU.1 is required for the development of macrophages, granulocytes, and B lymphocytes. Additionally its protein concentration in multipotential hematopoietic progenitor cells regulates cell fate decisions with high levels of PU.1 directing myeloid cell fate acquisition and low levels directing B cell fate acquisition. Potentially high levels of PU.1 are required for myeloid development in order to overcome repressive effects of B cell lineage specific factors. The essential B cell factor BSAP (Pax-5) was shown to associate with PU.1 and repress its transactivati
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Veiby, OP, SD Lyman, and SE Jacobsen. "Combined signaling through interleukin-7 receptors and flt3 but not c- kit potently and selectively promotes B-cell commitment and differentiation from uncommitted murine bone marrow progenitor cells." Blood 88, no. 4 (1996): 1256–65. http://dx.doi.org/10.1182/blood.v88.4.1256.bloodjournal8841256.

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Multiple cytokines can synergize to stimulate the in vitro proliferation and exclusive myeloid differentiation of multipotent bone marrow progenitor cells. The ligand for c-kit (stem cell factor [SCF]) plays a key role in stimulating myeloid and erythroid cell production of primitive hematopoietic progenitors. SCF in combination with interleukin-7 (IL-7) can also stimulate the combined myeloid and B-cell differentiation of uncommitted hematopoietic progenitor cells as well as the growth of early B-cell progenitor cells, although the involvement of c-kit in early B lymphopoiesis remains controv
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Zhou, Lan, Quanjian Yan, David Yao, Lebing W. Li, Stanton L. Gerson, and John B. Lowe. "Notch-Dependent Control of Blood Lineage Development is Modified by Fucosylation." Blood 112, no. 11 (2008): 2448. http://dx.doi.org/10.1182/blood.v112.11.2448.2448.

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Abstract Notch receptors are conserved cell surface molecules essential for hematopoietic cell fate determination. Activated Notch enhances self-renewal of hematopoietic stem cells and promotes T lymphopoiesis. O-linked fucose moieties attached to the EGF domains of Notch receptors and its modification by Fringe can strongly modulate Notch signaling. Our recently published results indicate that Notch-dependent signaling controls myelopoiesis both in vitro and in vivo, and identify a requirement for Notch fucosylation in the expression of Notch ligand binding activity and Notch signaling effici
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Anderlini, Paolo, and Richard E. Champlin. "Biologic and molecular effects of granulocyte colony-stimulating factor in healthy individuals: recent findings and current challenges." Blood 111, no. 4 (2008): 1767–72. http://dx.doi.org/10.1182/blood-2007-07-097543.

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Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widely used in healthy donors for collection of peripheral blood progenitor cells (PBPCs) for allogeneic transplantation and granulocytes for transfusion. The spectrum of its biologic and molecular activities in healthy individuals is coming into sharper focus, creating a unique set of challenges and clarifying the need to monitor and safeguard donor safety. Accumulating evidence indicates that rhG-CSF effects are not limited to the myeloid cell lineage. This may reflect the presence of functional G-CSF receptors on other cel
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Papapetrou, Eirini P., Damian Kovalovsky, Laurent Beloeil, Derek Sant’Angelo, and Michel Sadelain. "microRNA-Mediated Gene Regulation Effectively Restricts In Vivo Transgene Expression in Hematopoietic Stem Cell Progeny." Blood 110, no. 11 (2007): 193. http://dx.doi.org/10.1182/blood.v110.11.193.193.

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Abstract Stem cell engineering and targeted in vivo gene delivery increasingly require tight control of transgene expression. Lineage- and differentiation stage-specific gene regulation is classically afforded by pol-II-dependent transcript regulation. A super-imposed layer of post-transcriptional control would be valuable to correct undesirable expression patterns or fine-tune developmentally regulated or inducible gene expression. microRNAs (miRNAs) have recently emerged as potent repressors of gene expression at the post-transcriptional level. In this study, we investigate the potential of
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Dissertations / Theses on the topic "B-Lymphocytes Cell Lineage Granulocytes Myeloid Cells Receptors"

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King, R. Glenn. "On the immunological roles of TLT2 and HSH2." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008r/king.pdf.

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