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Journal articles on the topic 'B. Pavyer'

Author: Grafiati

Published: 26 July 2024

Last updated: 19 July 2025

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1

Contreras-Llanes, Manuel, Manuel Jesús Gázquez, and Maximina Romero. "Eco-Friendly Pavements Manufactured from Mixed Recycled Aggregates Obtained from Construction and Demolition Waste: An Industrial-Scale Validation." Materials 16, no. 24 (2023): 7544. http://dx.doi.org/10.3390/ma16247544.

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This study aimed to validate that laboratory-scale results could be commercially replicated when manufacturing marketable precast concrete. Construction and demolition waste (CDW) was separated into two (fine and coarse) recycled aggregates (RAs). Precast paver and kerb units were fabricated by partial or total substitution of natural aggregates (NAs) by RAs. The study involved the comprehensive characterisation of raw materials, including particle size distribution, mineral composition, and elemental composition. Paver blocks and kerbs manufactured with up to 50% RAs showed mechanical resistance (T = 3.7 ± 0.2 and B = 5.3 ± 0.6 MPa, respectively), water absorption between 5.3–5.7%, and abrasion resistance (approximately 20.2 mm), which met the standard requirements (UNE-EN 1340:2004 and UNE-EN 1338:2004). Furthermore, industrial-scale precast pavement units demonstrated strength and durability suitable for heavy traffic areas. A reduction of 13% in cement content could maintain the requirements with a partial RA substitution of 25%, offering economic and environmental benefits. Therefore, it is feasible at an industrial level to replace NAs with RAs, promoting durability and technological properties with a positive environmental impact and considerably reducing CO2 emissions by up to 65%. Overall, pavers with RAs manufactured at the laboratory scale met mechanical standards, and the kerb stones showed improvements in abrasion resistance. On an industrial scale, kerb stones and precast blocks with specific substitutions can meet strength, water absorption, and abrasion requirements, allowing a reduction in cement content.

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2

Knight, Athelia. "He Paved the Way for T. O. B. A." Black Perspective in Music 15, no. 2 (1987): 153. http://dx.doi.org/10.2307/1214675.

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Ball, Philip. "In search of sentience The Sentient Cell: The Cellular Foundations of Consciousness Arthur S. Reber, František Baluška, William B. Miller Jr. Oxford University Press, 2024. 288 pp." Science 383, no. 6688 (2024): 1186. http://dx.doi.org/10.1126/science.ado0065.

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Merola, Nicole M. ""for terror of the deadness beyond": Arctic Environments and Inhuman Ecologies in Michelle Paver’s Dark Matter // "por terror a lo inerte más allá": Entornos árticos y ecologías inhumanas en La materia oscura de Michelle Paver." Ecozon@: European Journal of Literature, Culture and Environment 5, no. 2 (2014): 23–40. http://dx.doi.org/10.37536/ecozona.2014.5.2.611.

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In this essay I examine Michelle Paver’s 2010 novel Dark Matter, a ghost story, for how her use of the gothic and horror contributes to undermining pastoral and romantic fantasies about the Arctic. Drawing on the history of whale, walrus, and seal hunting in Svalbard, the site of the novel’s 1937 scientific expedition, and my own experience there, I look at the tension Paver creates between the beauty of the Svalbard environment and its long history as a location for human violence against nonhuman animals. I suggest that, through the figure of the gengånger, or “one who walks again,” and the built environment and relics in Svalbard, Paver works to transmit both the violence of harvesting marine mammals and the violence men perpetrate against each other in the name of resource extraction. In this essay I engage in dialogue with recent environmental humanities work on ecophobia, dark ecologies, and the ecocritical uses of fear, and argue for the consideration of the ghost story, a genre little studied by ecocritics. Through highlighting the novel’s focus on violence linked to extractive practices, I suggest, finally, that Dark Matter performs two important functions: it records past inhuman ecologies and it opens out onto a reading of contemporary Arctic geopolitics. Resumen Este ensayo analiza cómo el uso de narrativas góticas y de terror en la novela de Michelle Paver Dark Matter (La materia oscura, 2010), un cuento de fantasmas, debilita las fantasías bucólicas y románticas del Ártico. Recurriendo a la historia de la caza de ballenas, morsas y focas en Svalbard, el emplazamiento de la expedición científica de 1937 de la novela, así como mi propia experiencia allí, analizo la tensión creada por Paver entre la belleza del medio ambiente de Svalbard y su larga historia como lugar de violencia humana contra animales no-humano. Sugiero que, a través de la figura del gengänger, o “el que anda otra vez,” las reliquias y el medio ambiente construido de Svalbard, Paver intenta transmitir tanto la violencia de la cosecha y comercio de mamíferos marinos como la que perpetúan los hombres contra sí mismos en nombre de la extracción de recursos. En este ensayo entro en dialogo con el trabajo reciente de las humanidades medioambientales sobre la ecofobia, las ecologías oscuras, y el uso del miedo en la ecocrítica, y propongo el estudio del cuento de fantasmas, un género que ha recibido poca atención de los ecocríticos. Al destacar el foco de la novela sobre la violencia relacionada con las prácticas de extracción, sugiero, finalmente, que Dark Matter, tiene dos funciones importantes: graba ecologías inhumanas del pasado y abre una lectura de la geopolítica del Ártico contemporánea.

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Caan, Woody. "Bush plans to screen whole US population for mental illness: Is road of initiative paved with good intentions?" BMJ 329, no. 7460 (2004): 292.3. http://dx.doi.org/10.1136/bmj.329.7460.292-b.

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Steinbach, Alexander, and Peter Rott. "Paving Low-Temperature Asphalt on the B 169 Highway Near Heyda." ACC JOURNAL 30, no. 1 (2024): 7–17. http://dx.doi.org/10.2478/acc-2024-0001.

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Abstract Research into lowering the temperature during the production and installation of hot asphalt has been going on for a long time. In addition to developing appropriate recipes, it is important to gain experience, particularly in asphalt paving technology, since in addition to the behavior of the different asphalt mixtures during their compaction, external factors such as the location of the project and weather conditions also play an important role. The testing of the low-temperature asphalt on the federal highway B 169 was carried out successfully. Due to the high pre-compaction by the paver screed, the required compaction values were achieved on the binder course with 4 rolling passes and on the surface course with 3 rolling passes. The viscosity-changing additives and the selected rolling technology had a positive influence on the results. However, precise measurement results for compaction could not be achieved using the PQI probe.

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Ermilov, Sergey G., Vasiliy B. Kolesnikov, Jenő Kontschán, and Pavel B. Klimov. "Taxonomic contribution to the knowledge of Galumnidae (Acari, Oribatida, Galumnidae) from Cuba." Zootaxa 5258, no. 4 (2023): 465–74. https://doi.org/10.11646/zootaxa.5258.4.7.

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Ermilov, Sergey G., Kolesnikov, Vasiliy B., Kontschán, Jenő, Klimov, Pavel B. (2023): Taxonomic contribution to the knowledge of Galumnidae (Acari, Oribatida, Galumnidae) from Cuba. Zootaxa 5258 (4): 465-474, DOI: 10.11646/zootaxa.5258.4.7, URL: http://dx.doi.org/10.1094/PDIS-04-22-0755-PDN

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ErmilovK, Sergey G., Jenő KontschánK, K. Vasiliy B. Kolesnikov, Pavel B. KlimovK, and Denis V. SharapovK. "Faunistic and taxonomic additions to the oribatid mites (Acari, Oribatida) of Cuba." Acarologia 63, no. 3 (2023): 770–82. https://doi.org/10.24349/hi71-nsch.

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ErmilovK, Sergey G., KontschánK, Jenő, Kolesnikov K, Vasiliy B., KlimovK, Pavel B., SharapovK, Denis V. (2023): Faunistic and taxonomic additions to the oribatid mites (Acari, Oribatida) of Cuba. Acarologia 63 (3): 770-782, DOI: 10.24349/hi71-nsch, URL: http://dx.doi.org/10.24349/hi71-nsch

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Barannikov, Aleksandr Grigor’evich, and Sergey Sergeevich Potapov. "Pavel Ivanovich Kutyukhin (1899–1962) and former kutyukhinite (now kumtyubeite)." NEWS of the Ural State Mining University, no. 2 (June 15, 2023): 180–86. http://dx.doi.org/10.21440/2307-2091-2023-2-180-186.

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Pavel Ivanovich Kutyukhin, a prominent specialist in geology and mineralogy of gold, rare metal and tungsten deposits of the Urals. For about 15 years he headed the departments of exploration and geology of ore deposits of the Geological Exploration Faculty at the Sverdlovsk Mining Institute. In honor of Pavel Ivanovich, a new mineral was named – kutyukhinite, calcium fluorosilicate, which was discovered by B. V. Chesnokov in the burnt dumps of the Chelyabinsk coal basin. The International Mineralogical Association did not approve it as a new mineral species, and recently a natural analogue, kumtyubeite, was found in the North Caucasus.

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Rusdiansyah, Yasruddin Yasruddin, Adriani Adriani, and Fauzi Rahman. "A study on utilization of coal ash for construction materials." Technium: Romanian Journal of Applied Sciences and Technology 25 (October 21, 2024): 34–43. http://dx.doi.org/10.47577/technium.v25i.11836.

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During coal combustion, steam power plants have fly and bottom ash as by-products. However, according to Indonesian Government Regulation No.104 of 2014 on the management of hazardous and toxic waste, both fly ash with B409 code and bottom ash with B410 code are categorized as level-2 hazardous and toxic materials. A material can be categorized as a level-2 dangerous and toxic material due to its contents, has a delayed effect, an indirect effect on humans and the environment, and has sub-chronic or chronic toxicity. One of the proposed solutions for this problem is to utilize fly ash and bottom ash as an added material or substitute material for paver blocks, concrete blocks, road curbs, and road bases. This study aimed to determine the right composition of fly ash and bottom ash on paver block, concrete block, road curb, and road base to meet the minimum requirements. This study is expected to confirm the utilization of coal ash material for construction materials. Based on the results, the coal ash material in the form of fly ash and bottom ash could be used as an added material or substitute material for paver blocks, concrete blocks, road curbs, and road bases. The composition of fly ash and bottom ash as construction materials have met SNI 03 - 0349 - 1989 requirements on compressive strength for class II (K-70) concrete quality, then Job Mix Formula K-250 which refers to SNI 03-2834-2000 for road curb, then SNI 03 - 0691 - 1996 on the compressive strength requirements for quality B concrete bricks for paver blocks and roadblocks.

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KlimovK, Pavel B., K. Vasiliy B. Kolesnikov, Alexander A. KhaustovK, and K. Barry M. OConnor. "A new mite species Fagacarus absalom sp. n. (Astigmata: Acaridae) from the Eastern Palearctic, with 18 rRNA molecular barcodes." Acarologia 64, no. 2 (2024): 542–53. https://doi.org/10.24349/0j5b-083x.

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KlimovK, Pavel B., Kolesnikov K, Vasiliy B., KhaustovK, Alexander A., OConnor K, Barry M. (2024): A new mite species Fagacarus absalom sp. n. (Astigmata: Acaridae) from the Eastern Palearctic, with 18 rRNA molecular barcodes. Acarologia 64 (2): 542-553, DOI: 10.24349/0j5b-083x, URL: http://dx.doi.org/10.24349/0j5b-083x

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Kolesnikov, Vasiliy B., Pavel B. Klimov, Alexander A. Khaustov, Almir Pepato, and Olga L. Makarova. "A new arenicolous species of the genus Thyreophagus (Acari: Acaridae) from the Caspian sea coast: Taxonomy and ecological insights." Zootaxa 5556, no. 1 (2024): 252–67. https://doi.org/10.11646/zootaxa.5556.1.19.

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Kolesnikov, Vasiliy B., Klimov, Pavel B., Khaustov, Alexander A., Pepato, Almir, Makarova, Olga L. (2024): A new arenicolous species of the genus Thyreophagus (Acari: Acaridae) from the Caspian sea coast: Taxonomy and ecological insights. Zootaxa 5556 (1): 252-267, DOI: 10.11646/zootaxa.5556.1.19, URL: https://doi.org/10.11646/zootaxa.5556.1.19

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Peshkov, Igor. "BAKHTIN QUESTION. THE SECOND ARTICLE: PAVEL NIKOLAEVICH MEDVEDEV." Literaturovedcheskii Zhurnal, no. 2 (2022): 89–111. http://dx.doi.org/10.31249/litzhur/2022.56.06.

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In the article a short biography of Pavel Nikolaevich Medvedev is demonstrated from the standpoint of his participation in Bakhtin’s circle and his publications under his own name a number of Bakhtin’s works, begun by the methodological article “Scientific Salierism” (1925), continued with reviews of the books of V. Shklovsky and B. Tomashevsky, a detailed replica “Sociologism without sociology” on the occasion of P.N. Sakulin’s monograph “Sociological method in literary criticism” (1925) and brought to great methodological clarity by the book “The Formal Method in Literary Criticism. A Critical Introduction to Sociological Poetics” (1928). The Medvedev’s management has been emphasized in the publication of these works, as well as the books “Freudianism. A Critical Sketch” (1927), “Marxism and the Philosophy of Language. Fundamental Problems of the Sociological Method in the Science of Language” (1929) and the several articles and reviews published under the title authorship of Voloshinov, and the book under the clear authorship of Bakhtin “Problems of Dostoevsky’s Creation” (1929). The mediating role of Medvedev between the authorities and the intelligentsia in Vitebsk and Leningrad in the 1920 s - 1930 s is presented.

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Krasov, Vladimir Vladimirovich. "“Singing about the germination of the world” by Boris Filanovsky: Musical reading of Pavel Filonovʼs poem". Manuscript 17, № 3 (2024): 241–49. http://dx.doi.org/10.30853/mns20240033.

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The article is devoted to the analysis of the vocal and symphonic creativity of B. Filanovsky. The purpose of the study is to reveal the features of composer’s writing using the example of an composition “Singing about the Germination of the World”. Scientific novelty is due to the fact that Boris Filanovsky’s “Singing about the germination of the world” is considered for the first time in the aspect of the interaction of the literary basis and techniques of compositional writing. The work of B. Filanovsky is specifically studied in a comprehensive manner from the point of view of genre specifics, stylistic features, and technical features of performance. Based on the poetic work, B. Filanovsky, preserving the classically established type of oratorio with a numbered structure, creates a complex vocal-symphonic composition, rich in innovative performing techniques. As a result of the study, the fact is substantiated that the choral composition under consideration becomes the most important in the context of the composer’s vocal and symphonic creativity.

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Miko, Ladislav, Vasiliy B. Kolesnikov, Sergey G. Ermilov, and Pavel B. Klimov. "Taxonomy of European Damaeidae (Acari, Oribatida) XI. European species of the genus Piribelba Miko 2021: redescriptions of P. rossica (Bulanova-Zachvatkina 1957) and P. piriformis (Mihelčič, 1964) using morphology and DNA sequence data." Zootaxa 5187, no. 1 (2022): 169–210. https://doi.org/10.11646/zootaxa.5187.1.11.

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Miko, Ladislav, Kolesnikov, Vasiliy B., Ermilov, Sergey G., Klimov, Pavel B. (2022): Taxonomy of European Damaeidae (Acari, Oribatida) XI. European species of the genus Piribelba Miko 2021: redescriptions of P. rossica (Bulanova-Zachvatkina 1957) and P. piriformis (Mihelčič, 1964) using morphology and DNA sequence data. Zootaxa 5187 (1): 169-210, DOI: 10.11646/zootaxa.5187.1.11

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Ermilov, Sergey G., and Pavel B. Klimov. "Generic revision of the large-winged mite superfamilY Galumnoidea (Acari, Oribatida) of the world." Zootaxa 4357, no. 1 (2017): 1–72. https://doi.org/10.11646/zootaxa.4357.1.1.

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Gongalsky, Konstantin B., Pavel S. Nefediev, and Ilya S. Turbanov. "A new species of the genus Lucasioides Kwon, 1993 (Isopoda, Oniscidea,Agnaridae) from Siberia, Russia." Zootaxa 4903, no. 1 (2021): 140–50. https://doi.org/10.11646/zootaxa.4903.1.9.

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Gongalsky, Konstantin B., Nefediev, Pavel S., Turbanov, Ilya S. (2021): A new species of the genus Lucasioides Kwon, 1993 (Isopoda, Oniscidea,Agnaridae) from Siberia, Russia. Zootaxa 4903 (1): 140-150, DOI: 10.11646/zootaxa.4903.1.9

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Apanaskevich, Dmitry A., Maria A. Apanaskevich, Pavel B. Klimov, et al. "Description of eight new species of Ixodes Latreille, 1795 (Acari: Ixodidae) and redescription of I. auritulus Neumann, 1904, parasites of birds in the Australasian, Nearctic and Neotropical Regions." Zootaxa 5173, no. 1 (2022): 1–73. https://doi.org/10.11646/zootaxa.5173.1.1.

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Apanaskevich, Dmitry A., Apanaskevich, Maria A., Klimov, Pavel B., Edgy, Brett M., Bermúdez, Sergio E., Labruna, Marcelo B., Korzeev, Andrei I., Barker, Stephen C. (2022): Description of eight new species of Ixodes Latreille, 1795 (Acari: Ixodidae) and redescription of I. auritulus Neumann, 1904, parasites of birds in the Australasian, Nearctic and Neotropical Regions. Zootaxa 5173 (1): 1-73, DOI: 10.11646/zootaxa.5173.1.1, URL: http://dx.doi.org/10.11646/zootaxa.5173.1.1

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Klimov, Pavel B., Barry Oconnor, and Alexander A. Khaustov. "Naiadacarus sidorchukae sp. n. (Acariformes: Acaridae) from Western Siberia closely related to a North American species, with a new generic synonymy." Zootaxa 4647, no. 1 (2019): 441–56. https://doi.org/10.11646/zootaxa.4647.1.28.

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Klimov, Pavel B., Oconnor, Barry, Khaustov, Alexander A. (2019): Naiadacarus sidorchukae sp. n. (Acariformes: Acaridae) from Western Siberia closely related to a North American species, with a new generic synonymy. Zootaxa 4647 (1): 441-456, DOI: 10.11646/zootaxa.4647.1.28

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Chetverikov, Philipp E., Alexey G. Desnitskiy, Pavel B. Klimov, Sebahat K. Ozman-Sullivan, Anna E. Romanovich, and Sogdiana I. Sukhareva. "Tuerkayana rotundum." Zoological Studies 62, no. 35 (2023): 1–18. https://doi.org/10.6620/ZS.2023.62-35.

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Chetverikov, Philipp E., Desnitskiy, Alexey G., Klimov, Pavel B., Ozman-Sullivan, Sebahat K., Romanovich, Anna E., Sukhareva, Sogdiana I. (2023): Tuerkayana rotundum. Zoological Studies 62 (35): 1-18, DOI: 10.6620/ZS.2023.62-35, URL: http://dx.doi.org/10.5281/zenodo.8056069

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Kharb, Dr Sunil Devi. "<b>Haryana Vidhan Sabha Election 2024: Explaining the Verdict</b>." Knowledgeable Research A Multidisciplinary Journal 4, no. 04 (2025): 50–69. https://doi.org/10.57067/1egdtb58.

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Abstract: The present paper is a modest attempt to interpret, explain, and analyze the electoral verdict and performance of various political parties in the 2024 Vidhan Sabha elections of Haryana. The Haryana assembly polls marked an unprecedented moment as the verdict given by the people is contrary to the conceived popular public sentiment, wave in favor of Congress, issue of retaining Jat dominance, Jawan-Kisan-Pahalwan, predictions of political pundits, and exit polls. BJP not only overcame anti-incumbency sentiments to secure a third consecutive term but also created a history of its own in the state politics through social engineering, organizational skills, and electoral maneuvering. With 48[i] out of 90 seats, the BJP emerged victorious despite being in powers for 10 years. Content analysis of various published resources before and after the election shows that even after anti-incumbency against BJP and Jat consolidation in favor of Congress, BJP's focused ground-level strategy combined with an agenda of development, a targeted campaign focused on delivering a clear narrative, and unified leadership washed away the anti-incumbency agenda against it, which the state is known for. While the shift of Dalit support from Congress to BJP, internal bickering and factionalism, vote-splitting due to independent candidates paved the way for the defeat of Congress. This paper also discusses the performance of major political parties in the light of caste calculous and other dynamics such jat-non Jat, rural-urban cleavage. [i] It became 51 after all the 3 Independents provided their support to BJP

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Sujiartono, Ari, and Sri Wiwoho Mudjanarko. "Characteristics Analysis of Modification Asbuton Granular B 50/30 With Asphalt Pen 60/70." SPIRIT OF SOCIETY JOURNAL 6, no. 1 (2022): 62–71. http://dx.doi.org/10.29138/scj.v6i1.1732.

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In the framework of handling the bending pavement road, natural materials in the form of asphalt as a binding material in a hot paved blend are needed. One of the abundant natural asphaltic that has not been used to its fullest is Asbuton. The government through the Ministry of Public Works which is currently transformed into the Ministry of Public Works and Public Housing has issued Public Works Regulation No. 35 of 2006 on Increasing the Utilization of Buton Asphalt for Road Maintenance and Development. Because various things that cause permission to use 100% Asbuton in hot paved blends can not be issued, the use of Asbuton is still limited to improving the quality of asphalt Pen 60/70. This research aims to obtain an optimal composition in the use of Asbuton using the type of Asbuton Grain B 50/30. It is hoped that the results of the research can be an additional reference for Asbuton producers as well as a new insight for civil engineering students who explore the path of bending pavement. The results showed that Asbuton Granular B 50/30 can be used in improving the quality of Asphalt Pen 60/70 with an optimal composition of 25% Asbuton Granular B 50/30 and 75% Asphalt Pen 60/70.

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KhaustovK, Alexander A., Vladimir A. KhaustovK, and K. Pavel B. Klimov. "A new subcortical mite, Divilia orbiculata n. sp. (Acari: Hemisarcoptidae), from Siberia based on adults and phoretic deutonymphs." Acarologia 64, no. 1 (2024): 123–37. https://doi.org/10.24349/c9a2-3j04.

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KhaustovK, Alexander A., KhaustovK, Vladimir A., Klimov K, Pavel B. (2024): A new subcortical mite, Divilia orbiculata n. sp. (Acari: Hemisarcoptidae), from Siberia based on adults and phoretic deutonymphs. Acarologia 64 (1): 123-137, DOI: 10.24349/c9a2-3j04, URL: http://dx.doi.org/10.24349/c9a2-3j04

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Baltrusch, Simone. "The Role of Neurotropic B Vitamins in Nerve Regeneration." BioMed Research International 2021 (July 13, 2021): 1–9. http://dx.doi.org/10.1155/2021/9968228.

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Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are key players, which maintain the neuronal viability in different ways. Firstly, they constantly protect nerves against damaging environmental influences. While vitamin B1 acts as a site-directed antioxidant, vitamin B6 balances nerve metabolism, and vitamin B12 maintains myelin sheaths. However, nerve injury occurs at times, because of an imbalance between protective factors and accumulating stress and noxae. This will result in the so-called Wallerian degeneration process. The presence of vitamins B1, B6, and B12 paves the way out to the following important regeneration by supporting the development of new cell structures. Furthermore, vitamin B1 facilitates the usage of carbohydrates for energy production, whereas vitamin B12 promotes nerve cell survival and remyelination. Absence of these vitamins will favor permanent nerve degeneration and pain, eventually leading to peripheral neuropathy.

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Bochkov, Andre V., Pavel B. Klimov, Da-Hee Kim, and Maciej Skoracki. "Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris." Zootaxa 4544, no. 4 (2019): 523–47. https://doi.org/10.11646/zootaxa.4544.4.4.

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Bochkov, Andre V., Klimov, Pavel B., Kim, Da-Hee, Skoracki, Maciej (2019): Validation of the status of a species with high CO1 and low nuclear genetic divergences: the scab mite Caparinia ictonyctis stat. res. (Acariformes: Psoroptidae) parasitizing the African hedgehog Atelerix albiventris. Zootaxa 4544 (4): 523-547, DOI: 10.11646/zootaxa.4544.4.4

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Bochkov, Andre V., Pavel B. Klimov, and Georges Wauthy. "Phylogeny and coevolutionary associations of makialgine mites (Acari, Psoroptidae, Makialginae) provide insight into evolutionary history of their hosts, strepsirrhine primates." Zoological Journal of the Linnean Society 162, no. 1 (2011): 1–14. https://doi.org/10.1111/j.1096-3642.2010.00666.x.

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Bochkov, Andre V., Klimov, Pavel B., Wauthy, Georges (2011): Phylogeny and coevolutionary associations of makialgine mites (Acari, Psoroptidae, Makialginae) provide insight into evolutionary history of their hosts, strepsirrhine primates. Zoological Journal of the Linnean Society 162 (1): 1-14, DOI: 10.1111/j.1096-3642.2010.00666.x, URL: http://dx.doi.org/10.1111/j.1096-3642.2010.00666.x

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Höge, Holger. "Fechner in Context: Aesthetics from Below, Inner and Outer Psychophysics: A Reply to Pavel Machotka." Empirical Studies of the Arts 15, no. 1 (1997): 91–97. http://dx.doi.org/10.2190/1wau-hxvq-cc6e-unth.

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In his recent article Machotka [1] has discussed several difficulties of Fechner's unique approach to look for progress in the field of aesthetics: from below. Machotka proposed a radically different methodology: (a) perception of interrelations, (b) giving form to content, (c) fitting form to content, and (d) bending rules. My basic argument is that his new methodology is still based on Fechner's methods, i.e., from below, however, on a higher level of complexity. Finally, some light is cast on the role Fechner assigned to the two parts of psychophysics: inner and outer psychophysics and their relation to aesthetics.

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Yoon, Hyo In, Hyun Young Kim, Jaewoo Kim, Myung-Min Oh, and Jung Eek Son. "Quantitative Analysis of UV-B Radiation Interception in 3D Plant Structures and Intraindividual Distribution of Phenolic Contents." International Journal of Molecular Sciences 22, no. 5 (2021): 2701. http://dx.doi.org/10.3390/ijms22052701.

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Ultraviolet-B (UV-B) acts as a regulatory stimulus, inducing the dose-dependent biosynthesis of phenolic compounds such as flavonoids at the leaf level. However, the heterogeneity of biosynthesis activation generated within a whole plant is not fully understood until now and cannot be interpreted without quantification of UV-B radiation interception. In this study, we analyzed the spatial UV-B radiation interception of kales (Brassica oleracea L. var. Acephala) grown under supplemental UV-B LED using ray-tracing simulation with 3-dimension-scanned models and leaf optical properties. The UV-B-induced phenolic compounds and flavonoids accumulated more, with higher UV-B interception and younger leaves. To distinguish the effects of UV-B energy and leaf developmental age, the contents were regressed separately and simultaneously. The effect of intercepted UV-B on flavonoid content was 4.9-fold that of leaf age, but the effects on phenolic compound biosynthesis were similar. This study confirmed the feasibility and relevance of UV-B radiation interception analysis and paves the way to explore the physical and physiological base determining the intraindividual distribution of phenolic compound in controlled environments.

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Ni, Yen-Hsuan, and Mei-Hwei Chang. "The ways paved for prophylaxis againstde novohepatitis B virus infection after liver transplantation: still many stones left unturned." Pediatric Transplantation 10, no. 4 (2006): 405–7. http://dx.doi.org/10.1111/j.1399-3046.2006.00494.x.

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McIntosh, E. David G. "Development of vaccines against gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus." Clinical Microbiology and Antimicrobial Chemotherapy 21, no. 4 (2019): 253–60. http://dx.doi.org/10.36488/cmac.2019.4.253-260.

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The success in preventing hepatitis B virus and human papillomavirus infections by means of vaccination paves the way for the development of other vaccines to prevent sexually transmitted infections (STIs) such as gonorrhoea, syphilis, chlamydia, herpes simplex virus, human immunodeficiency virus and Zika virus. The current status of vaccine development for these infections will be explored in this review.

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Orlova, Maria V., Pavel B. Klimov, Nina S. Moskvitina, et al. "New records of bat flies (Diptera: Nycteribiidae), with an updated checklist of the nycteribiids of Russia." Zootaxa 4927, no. 3 (2021): 410–30. https://doi.org/10.11646/zootaxa.4927.3.5.

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Orlova, Maria V., Klimov, Pavel B., Moskvitina, Nina S., Orlov, Oleg L., Zhigalin, Alexander V., Smirnov, Dmitriy G., Dzhamirzoyev, Hadzhibek S., Vekhnik, Vladimir P., Pavlov, Alexander V., Emelyanova, Alla A., Khristenko, Ekaterina (2021): New records of bat flies (Diptera: Nycteribiidae), with an updated checklist of the nycteribiids of Russia. Zootaxa 4927 (3): 410-430, DOI: 10.11646/zootaxa.4927.3.5

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Samudrala, Gopi, Kallol Chakrabarty, Paul A. Baker, Bernabe S. Tucker, Yogesh K. Vohra, and Shane A. Catledge. "Selective Deposition of Hard Boron-Carbon Microstructures on Silicon." Materials 14, no. 6 (2021): 1397. http://dx.doi.org/10.3390/ma14061397.

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Boron-rich B-C compounds with high hardness have been recently synthesized by the chemical vapor deposition (CVD) method. In this paper, we present our successful efforts in the selective growth of microstructures of boron-carbon compounds on silicon substrates. This was achieved by combining microfabrication techniques such as maskless lithography and sputter deposition with the CVD technique. Our characterization studies on these B-C microstructures showed that they maintain structural and mechanical properties similar to that of their thin-film counterparts. The methodology presented here paves the way for the development of microstructures for microelectromechanical system (MEMS) applications which require custom hardness and strength properties. These hard B-C microstructures are an excellent choice as support structures in MEMS-based devices.

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Chalbi, Nadia. "<b>LA VIE RÊVÉE D’HAJERI. PORTRAIT D’AHMED HAJERI, DEVENU PEINTRE PARISIEN </b>." Manazir Journal 6 (May 14, 2025): 214–40. https://doi.org/10.36950/manazir.2024.6.9.

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Abstract : Ahmed Hajeri is a French artist of Tunisian origin who lives and works in Paris. Born in the village of Tazarka, in the Cap Bon region, in 1948, he grew up in a very modest rural family. Orphaned at a young age, he was initially supposed to pursue a career as an electrician, when, at twenty, he decided to leave for France. Upon his arrival in Paris, he worked as an electrical wirer in a factory before applying for a draftsman position with a cultured architect who was close to Jean Dubuffet. This architect, Roland Morand, recognized Hajeri's artistic potential, introduced him to art, and paved the way for his career as a painter. Hajeri fully embraced life as an artist after his first exhibition at Galerie Messine in 1978. He achieved success early on and gained recognition from both the public and Tunisian institutions during his first exhibition at Galerie Médina in Tunis in 1985. He later participated in several international exhibitions. His work is held in French public collections (FNAC), the Institut du monde arabe in Paris, Tunisian national collections (Ministry of Cultural Affairs) and in numerous private collections. With no formal academic training, the artist has developed a body of work that transcends trends and fashions, existing on the border between the real and the imaginary. Floating figures, an anthropomorphic bestiary, and vestiges of Carthaginian civilization populate his compositions. He draws inspiration from childhood memories and dreamlike states, creating paintings, drawings and poems infused with imagination and mystery. Based on interviews and unpublished archives, this portrait traces the artist's journey between Tunis and Paris, exploring the themes and influences that have shaped his work and its critical reception.

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Phalen, Thomas E. "Discussion of “ Wind Effects on Roof Ballast Pavers ” by B. Bienkiewicz and R. N. Meroney (June, 1988, Vol. 114, No. 6)." Journal of Structural Engineering 116, no. 5 (1990): 1462–64. http://dx.doi.org/10.1061/(asce)0733-9445(1990)116:5(1462).

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Bienkiewicz, B., and R. N. Meroney. "Closure to “ Wind Effects on Roof Ballast Pavers ” by B. Bienkiewicz and R. N. Meroney (June, 1988, Vol. 114, No. 6)." Journal of Structural Engineering 116, no. 5 (1990): 1464–65. http://dx.doi.org/10.1061/(asce)0733-9445(1990)116:5(1464.2).

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Svobodová, Hana, Milan Bartoš, Miriam Nývltová Fišáková, and Pavel Kouřil. "Genetic Analysis Of Possibly The Oldest Greyhound Remains Within The Territory Of The Czech Republic As Proof Of A Local Elite Presence At Chotěbuz-Podobora Hillfort In The 8 -9 Century Ad." Acta Musei Nationalis Pragae Series B 71, no. 1-2 (2015): 17–24. https://doi.org/10.14446/AMNP.2015.17.

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Svobodová, Hana, Bartoš, Milan, Fišáková, Miriam Nývltová, Kouřil, Pavel (2015): Genetic Analysis Of Possibly The Oldest Greyhound Remains Within The Territory Of The Czech Republic As Proof Of A Local Elite Presence At Chotěbuz-Podobora Hillfort In The 8 -9 Century Ad. Acta Musei Nationalis Pragae Series B 71 (1-2): 17-24, DOI: 10.14446/AMNP.2015.17, URL: http://dx.doi.org/10.14446/amnp.2015.17

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Steyer, J. Sebastien. "The geological and palaeontological exploration of Laos; following in the footsteps of J. B. H. Counillon and A. Pavie." Geological Society, London, Special Publications 315, no. 1 (2009): 25–32. http://dx.doi.org/10.1144/sp315.3.

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Klioštoraitytė, Rasa. "P. P. PASOLINI’O POEZIJOS VERTIMO PROBLEMATIKA." Vertimo studijos 1, no. 1 (2017): 104. http://dx.doi.org/10.15388/vertstud.2008.1.10622.

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Šio straipsnio tikslas – analizuojant P. P. Pasolini’o eilėraščių vertimus iš italų k. į lietuvių k. ir lyginant juos su tekstais originalo k. ištirti, ar vertėjui pavyko perteikti pagrindinius autoriaus poetikos ir stiliaus bruožus. Straipsnio pradžioje supažindinama su P. P. Pasolini’o kūrinių vertimais į lietuvių kalbą ir šio menininko kūrybos tyrinėjimais Lietuvoje. Toliau trumpai aptariama P. P. Pasolini’o poetika. Analizuojant išverstus eilėraščius remiamasi A. Popovičiaus ir J. Homleso (J. Homles) vertimo teorijomis bei B. Osimo vertimo raštu metodologija. Straipsnio pabaigoje pateikiamas svarbiausios literatūros ir šaltinių sąrašas.

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Santos, Leonardo de Lima, and Samuel Bueno Soltau. "The Unified Era: An understanding journey from observations to the Unified Model of Active Galactic Nuclei<b></b>." Revista de Investigación de Física 27, no. 3 (2024): 72–83. https://doi.org/10.15381/rif.v27i3.27287.

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The Unified Model of Active Galactic Nuclei (UMAGN) serves as a comprehensive theoretical framework designed to elucidate the myriad observations of AGN, encompassing both quasars and Seyfert galaxies. This model attributes observed variations to distinct orientations of a circumnuclear matter disk around a supermassive black hole (SMBH). The primary factor influencing the observational diversity lies in the alignment of the AGN with the observer's line of sight. We provide an exhaustive overview of observational evidence, empirical and theoretical research, tracing pivotal milestones that have led to a unified perspective. Our exposition encapsulates the scientific journey culminating in the proposal of UMAGN, delving into insights regarding the accretion disk, torus, and relativistic jet. We emphasize key properties of objects within the UMAGN framework. Furthermore, we underscore recent progress in multimessenger research involving electromagnetic waves, gravitational waves, astroparticles, and neutrinos. Noteworthy collaborations, such as the Event Horizon Telescope, LIGO/Virgo, IceCube, Pierre Auger, and KM3Net, have significantly advanced this field. We argue that these collaborative efforts present opportunities to enhance and refine UMAGN, thereby contributing to a profound understanding of AGNs and their implications for the formation and evolution of galaxies. The convergence of observational and theoretical research, coupled with emerging multimessenger techniques, paves the way for substantial strides in comprehending these enigmatic cosmic phenomena.

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Wu, Lan, and Luc Van Kaer. "B cell subsets in pericardial adipose tissues and their role in cardiovascular health." Journal of Immunology 204, no. 1_Supplement (2020): 71.1. http://dx.doi.org/10.4049/jimmunol.204.supp.71.1.

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Abstract We have recently reported that murine pericardial adipose tissues house a large number of lymphoid clusters that have been referred to as fat-associated lymphoid clusters. We have further shown that these tertiary lymphoid tissues are enriched with B cells, in particular B-1a cells. These cells continuously produce a low level of IL-10 under unchallenged conditions, and further enhance the production of this cytokine upon stimulation. Following acute myocardial infarction (MI), these cells significantly expand in pericardial adipose tissues, and they accumulate in the infarcted heart during the resolution phase of MI-induced inflammation where they play a protective role by facilitating the termination of MI-induced inflammation. In our efforts to target B cells for the maintenance of cardiac health, we have now performed a comprehensive characterization of B cell subsets in murine pericardial adipose tissues focusing on cytokines. Using cytokine profiling, RNA sequencing and single-cell RNA sequencing analyses, we have found that subsets of B cells in pericardial adipose tissues are fundamentally biased. Whereas B-2 cells are equipped to produce more pro-inflammatory cytokines, B-1a cells are biased towards producing anti-inflammatory cytokines. These results have paved our way in designing effective therapeutic strategy to target subsets of B cells for the treatment of cardiovascular diseases.

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Kinderman, Daniel. "Donald Trump, anti-establishment populism and the revolving door between business and politics in the United States." Zeitschrift für Unternehmensgeschichte 68, no. 2 (2023): 289–314. http://dx.doi.org/10.1515/zug-2023-0015.

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Abstract Revolving door dynamics are pervasive in the United States. There are vast literatures on the revolving door and on Donald Trump, but so far, no attempts to bring these literatures together. This paper represents a first attempt to do so and answer the following questions: Can Trump’s rise be understood as a culmination of revolving door dynamics, under which managers become politicians and politicians become lobbyists? What motivated Trump to revolve, and how has Trump’s presidency affected the revolving door? The paper places Trump into the context of the revolving door and compares him with previous presidents and presidential candidates. In recent decades, revolving door activity has increased. While this suggests that the revolving door paved the way for Trump, a close examination of the evidence reveals a more complex picture. Many American businesspeople have unsuccessfully run for president. Like the businessmen-turned-presidents who preceded him, Trump is a family businessman, not a manager or a CEO of a listed company. A multitude of additional factors contributed to Trump’s 2016 win including his status as a reality TV celebrity, his charisma, and his right-wing populism: Trump is from business but not from the business establishment. In addition, Trump revolved from business into politics, rather than from Capitol Hill to K Street. Candidate Trump railed against the revolving door and pledged to drain the swamp. President Trump swamped the drain and precipitated one of the most serious crises and threats to American democracy in the country’s history.

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Ocampo, Yanet, Daneiva Caro, David Rivera, Jhoan Piermattey, Ricardo Gaitán, and Luis A. Franco. "Transcriptome Changes in Colorectal Cancer Cells upon Treatment with Avicequinone B." Advanced Pharmaceutical Bulletin 10, no. 4 (2020): 638–47. http://dx.doi.org/10.34172/apb.2020.077.

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Purpose: Naphtho[2,3-b]furan-4,9-dione (Avicequinone B), a natural naphthoquinone isolated from the mangrove tree Avicennia alba, is recognized as a valuable synthetic precursor with anti-proliferative effect. However, the molecular mechanism involved in its bioactivity has not been investigated. This study aimed to determine the selectivity of avicequinone B against cancer cells and the transcriptomic changes induced in colorectal cancer (CRC). Methods: The cytotoxic effect against adenocarcinoma-derived cells or fibroblasts was evaluated using MTT assay. In addition, CRC cells were treated with avicequinone B in different settings to evaluate colony-forming ability, cell cycle progression, apoptosis/necrosis induction, and transcriptome response by RNA-seq. Results: Avicequinone B effectively reduced the viability of breast, colorectal, and lung adenocarcinoma cells with IC50 lower than 10 μM, while fibroblasts were less affected. The induction of G2/M arrest and necrosis-like cell death were observed in avicequinone B-treated HT-29 cells. Furthermore, RNA-seq revealed 490 differentially expressed genes, highlighting the reduction of interferon stimulated genes and proliferative signaling pathways (JAK-STAT, MAPK, and PI3K-AKT), as well as the induction of ferroptosis and miR-21 expression. Conclusion: In short, these results demonstrated the therapeutic potential of avicequinone B and paved the foundation for elucidating its mechanisms in the context of CRC.

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Lebedev, Sergey A., Andrey G. Kostianoy, Murat K. Bedanokov, Asida K. Akhsalba, Roza B. Berzegova, and Pavel N. Kravchenko. "Climate Changes of the Temperature of the Surface and Level of the Black Sea by the Data of Remote Sensing at the Coast of the Krasnodar Krai and the Republic of Abkhazia." Ecologica Montenegrina 14 (October 30, 2017): 14–20. https://doi.org/10.37828/em.2017.14.2.

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Lebedev, Sergey A., Kostianoy, Andrey G., Bedanokov, Murat K., Akhsalba, Asida K., Berzegova, Roza B., Kravchenko, Pavel N. (2017): Climate Changes of the Temperature of the Surface and Level of the Black Sea by the Data of Remote Sensing at the Coast of the Krasnodar Krai and the Republic of Abkhazia. Ecologica Montenegrina 14: 14-20, DOI: 10.37828/em.2017.14.2, URL: https://www.biotaxa.org/em/article/view/em.2017.14.2

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Nittal, Vekaria* Pinakinbharthi Goswami. "Pharmacogenomics In Personalized Medicine." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 797–811. https://doi.org/10.5281/zenodo.15167707.

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Pharmacogenomics, the study of how an individual's genetic makeup influences their response to drugs, has emerged as a pivotal component in the realm of personalized medicine. The paper begins by elucidating the fundamental principles underlying pharmacogenomics and its role in optimizing drug therapy. It examines the link between genetic variations, drug metabolism pathways, and treatment outcomes, emphasizing the importance of identifying genetic biomarkers to predict drug response and adverse reactions. Recent breakthroughs in pharmacogenomic research have revolutionized clinical practice, enabling clinicians to make more informed decisions regarding drug selection, dosing, and monitoring. Discoveries of new genetic variants associated with drug metabolism to the development of sophisticated pharmacogenetic testing platforms, these advancements have paved the way for personalized approaches to patient care. One of the key findings underscored in this paper is the significant impact of pharmacogenomics on enhancing medication efficacy and safety across various therapeutic areas. By tailoring treatment regimens based on individual genetic profiles, healthcare providers can minimize the risk of adverse drug reactions and improve patient outcomes. Moreover, pharmacogenomic-guided dosing strategies also optimize therapeutic effectiveness while treatment failure or toxicity. Furthermore, the paper enhances pharmacogenomic testing in clinical settings and its integration into electronic health records, enhancing personalized healthcare delivery. Pharmacogenomics can significantly enhance medication management in complex conditions like cancer, cardiovascular diseases, and psychiatric disorders. In conclusion, this review underscores the transformative impact of pharmacogenomics on personalized medicine, emphasizing recent advances and key findings that underscore its significance in optimizing drug therapy and improving patient outcomes.

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He, Miaoxia, Bin Liu, Gusheng Tang, et al. "B2M mutation paves the way for immune tolerance in pathogenesis of Epstein-Barr virus positive diffuse large B-cell lymphomas." Journal of Cancer 13, no. 15 (2022): 3598–605. http://dx.doi.org/10.7150/jca.75813.

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Liu, Yongzhen, Stephanie Maya, and Alexander Ploss. "Animal Models of Hepatitis B Virus Infection–Success, Challenges, and Future Directions." Viruses 13, no. 5 (2021): 777. http://dx.doi.org/10.3390/v13050777.

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Chronic hepatitis B virus (HBV) infection affects more than 250 million people worldwide, which greatly increases the risk for terminal liver diseases, such as liver cirrhosis and hepatocellular carcinoma (HCC). Even though current approved antiviral therapies, including pegylated type I interferon (IFN) and nucleos(t)ide analogs, can effectively suppress viremia, HBV infection is rarely cured. Since HBV exhibits a narrow species tropism and robustly infects only humans and higher primates, progress in HBV research and preclinical testing of antiviral drugs has been hampered by the scarcity of suitable animal models. Fortunately, a series of surrogate animal models have been developed for the study of HBV. An increased understanding of the barriers towards interspecies transmission has aided in the development of human chimeric mice and has greatly paved the way for HBV research in vivo, and for evaluating potential therapies of chronic hepatitis B. In this review, we summarize the currently available animal models for research of HBV and HBV-related hepadnaviruses, and we discuss challenges and future directions for improvement.

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Pabiś-Mazgaj, Ewelina, Paweł Pichniarczyk, Agata Stempkowska, and Tomasz Gawenda. "Possibility of Using Natural Zeolite Waste Granules Obtained by Pressure Agglomeration as a Sorbent for Petroleum Substances from Paved Surfaces." Materials 15, no. 19 (2022): 6871. http://dx.doi.org/10.3390/ma15196871.

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Increasing incidents of oil spills and dynamic development of civilization are driving the demand for sorbents. The production of the overwhelming majority of mineral sorbents involves the highly energy-consuming calcination process with CO2 emissions impacting the environment. Taking into account the environmental issues related to greenhouse gas emissions, we are in urgent need of green products and green technologies. The aim of this study was to investigate the possibility of using natural zeolite dust waste to produce oil sorbents in non-calcination technology. The main advantage of the proposed solution is reduction of greenhouse gas emissions and transformation of the waste material into green, useful product. The scope of the research covered the experimental tests for compaction of the zeolite material from Ukraine and Slovakia in a roller press with different type of binding agent and the performance tests for assessing the suitability of the produced agglomerates as a petroleum sorbent. In order to evaluate the agglomerates’ properties, textural-structural analysis (optical microscopy, SEM microscopy, and low-temperature N2 sorption), petroleum sorption (Westinghouse method), and physical-mechanical tests (resistance to gravitational drop, abrasion resistance) were carried out. Properties of the manufactured agglomerates were studied in comparison to commercial sorbent DAMSORB, commonly used in Poland. The test results showed that it is doable to produce the effective surface oil-spill sorbent from zeolite waste dust in a roller press by applying the relevant binding agent. The main finding of this study was that optimum feed composition for dry granulation that provides the granular sorbent with the best properties was established: 6% of C binder and moisture content within a narrow range of 20–20.6%. The C-1 sorbent achieved the highest and closely comparable to commercial sorbent parameters of petroleum sorption and drop strength, which are key points of this study. The absorption efficiency of petroleum substances for C-1 sorbent is 8% lower than that of a commercial sorbent, and resistance to gravitational drop is lower by only 3%. However, commercial sorbent exhibited better abrasion resistance compared to produced agglomerates, which is a compelling reason to continue the research in order to enhance the abrasion performance of the manufactured granules. The effectiveness of the dust consolidation method carried out was proved by textural parameters of the obtained zeolite-based sorbents. Specific surface area (SBET) of B-2 (SBET = 28.1 m2/g) and C-2 (SBET = 28.3 m2/g) sorbents was very similar to the commercial sorbent (SBET = 28.1 m2/g). Interestingly, all granules produced from clinoptilolite dust from Slovakia (A-2, B-2, C-2) achieved an increase of 19%, 33%, and 35%, respectively, in volume of mesopores, compared to the commercial sorbent. Moreover, the presented granulation technology favorably affected the size of the specific surface area as well as volume and surface area of mesopores in the case of obtained zeolite-based sorbent A-1 and B-1, compared with the starting raw material. Zeolite-based sorbent A-1 and B-1 achieved an increase of 17% and 18%, respectively, in specific area surface and an increase of 35% and 12%, respectively, in mesopores volume, compared with the raw material. Finally, the results of this investigation proved that it is possible to produce the efficient oil sorbent in a much more eco-friendly and green way, compared with that of the commercial sorbent.

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Caloian, Andreea-Daniela, Miruna Cristian, Elena Calin, et al. "Epigenetic Symphony in Diffuse Large B-Cell Lymphoma: Orchestrating the Tumor Microenvironment." Biomedicines 13, no. 4 (2025): 853. https://doi.org/10.3390/biomedicines13040853.

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DLBCL is a testament to the complexity of nature. It is characterized by remarkable diversity in its molecular and pathological subtypes and clinical manifestations. Despite the strides made in DLBCL treatment and the introduction of innovative drugs, around one-third of patients face a relapse or develop refractory disease. Recent findings over the past ten years have highlighted the critical interplay between the evolution of DLBCL and various epigenetic mechanisms, including chromatin remodeling, DNA methylation, histone modifications, and the regulatory roles of non-coding RNAs. These epigenetic alterations are integral to the pathways of oncogenesis, tumor progression, and the development of therapeutic resistance. In the past decade, the identification of dysregulated epigenetic mechanisms in lymphomas has paved the way for an exciting field of epigenetic therapies. Crucially, these epigenetic transformations span beyond tumor cells to include the sophisticated network within the tumor microenvironment (TME). While the exploration of epigenetic dysregulation in lymphoma cells is thriving, the mechanisms affecting the functions of immune cells in the TME invite further investigation. This review is dedicated to weaving together the narrative of epigenetic alterations impacting both lymphoma cells with a focus on their infiltrating immune companions.

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Sapre, Ajay, Efthymia Papalexi, Alec Salvino, et al. "Simultaneous profiling of single-cell BCR clonal diversity and whole transcriptomes from diseased and healthy PBMCs in a single experiment using split-pool combinatorial barcoding." Journal of Immunology 212, no. 1_Supplement (2024): 0276_5971. http://dx.doi.org/10.4049/jimmunol.212.supp.0276.5971.

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Abstract Many autoimmune diseases are characterized by aberrant B cells which play a central role in pathogenesis. Each B cell expresses a B cell receptor (BCR), which determines its specificity in binding to different epitopes. For autoimmune diseases such as Rheumatoid Arthritis, Lupus, and Type 1 Diabetes our current understanding of the role of unique BCR repertoires is poorly understood; however, recent advances in single-cell RNA sequencing has allowed the field to simultaneously profile both the BCR and whole transcriptome leading to the characterization of clonal diversity of B cell subtypes. Traditional methods using microfluidic barcoding are low throughput (1,000s-10,000s of cells) and costly. To overcome these limitations, we developed a method to simultaneously characterize the BCR repertoire and full transcriptomes of up to 1 million cells from up to 96 samples in one experiment. For proof of concept, we applied this method to simultaneously profile the BCR and whole transcriptome on multiple healthy and diseased samples. Using the whole transcriptome data, we detected all major subtypes of B cells in peripheral blood. From the BCR data, we defined BCR isotypes, captured a majority of cells with a paired chain, detected full length chains, and differentiated dominant & rare clones. This technology paves the way for high-throughput and sensitive screening of BCR repertoires to further the understanding of B cell biology and disease.

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Fu, Tianyu, Yamin Wang, Mingfeng Ma, et al. "Isolation of Alginate-Degrading Bacteria from the Human Gut Microbiota and Discovery of Bacteroides xylanisolvens AY11-1 as a Novel Anti-Colitis Probiotic Bacterium." Nutrients 15, no. 6 (2023): 1352. http://dx.doi.org/10.3390/nu15061352.

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Alginate has been documented to prevent the development and progression of ulcerative colitis by modulating the gut microbiota. However, the bacterium that may mediate the anti-colitis effect of alginate has not been fully characterized. We hypothesized that alginate-degrading bacteria might play a role here since these bacteria could utilize alginate as a carbon source. To test this hypothesis, we isolated 296 strains of alginate-degrading bacteria from the human gut. Bacteroides xylanisolvens AY11-1 was observed to have the best capability for alginate degradation. The degradation and fermentation of alginate by B. xylanisolvens AY11-1 produced significant amounts of oligosaccharides and short-chain fatty acids. Further studies indicated that B. xylanisolvens AY11-1 could alleviate body weight loss and contraction of colon length, reduce the incidences of bleeding and attenuate mucosal damage in dextran sulfate sodium (DSS)-fed mice. Mechanistically, B. xylanisolvens AY11-1 improved gut dysbiosis and promoted the growth of probiotic bacteria, including Blautia spp. And Prevotellaceae UCG-001, in diseased mice. Additionally, B. xylanisolvens AY11-1 showed no oral toxicity and was well-tolerated in male and female mice. Altogether, we illustrate for the first time an anti-colitis effect of the alginate-degrading bacterium B. xylanisolvens AY11-1. Our study paves the way for the development of B. xylanisolvens AY11-1 as a next-generation probiotic bacterium.

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