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Journal articles on the topic 'B12 vitamins'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Al- Joufi, Fakhria, Mona A. El- Bana, Ihab Tewfik, and Mona Anwar. "EFFICACY OF COSUPPLEMENTATION THERAPY WITH VITAMINS B9, B12, AND D ON ENDOTHELIAL DYSFUNCTION IN STREPTOZOTOCIN-INDUCED DIABETIC RATS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 9 (2018): 407. http://dx.doi.org/10.22159/ajpcr.2018.v11i9.25361.

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Objective: This study evaluated the effects of Vitamins D, B9, and B12 given individually or combined in ameliorating some biochemical parameters related to endothelial dysfunction in diabetic rats.Methods: A total of 50 Sprague-Dawley male rats were divided into five groups: Control, diabetic, diabetic received Vitamin D, diabetic received Vitamins B9 and B12, and diabetic received Vitamins B9, B12, and D. At the end of 6 weeks, the rats were sacrificed and a set of assays was carried out to determine: Fasting blood sugar (FBS), lipid profile, nitric oxide (NO), homocysteine (Hcy), malondiald

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Isayev, Y. T., and X. X. Zokirova. "YULG’UN O’SIMLIGI TARKIBIDAGI SUVDA ERUVCHAN VITAMINLAR MIQDORINI ANIQLASH." Universal International Scientific Journal 2, no. 1 (2025): 76–82. https://doi.org/10.69891/3060-4540.2025.80.52.001.

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Maqolada yulg’un o’simligining guli va novda qismidagi suvda eruvchan B1, B2, B3, B6, B9, B12, C va PP vitaminlarning miqdorini YSSX metodi yordamida aniqlash bo‘yicha olib borilgan tadqiqot natijalari bayon qilingan. Olingan natijalar yulg`unning o`rganilgan qismlarida mazkur vitaminlar sezilarli darajada mavjud ekanligini, gulida B2, B9 va PP vitaminlari nisbatan ko`proq, poya qismida esa C vitamini ko`proqligini ko`rsatdi. Yulg’un o’simligida B12 vitamini topilmadi. В статье представлены результаты исследований, проведенных для количественного определения водорастворимых витаминов B1, B2, B

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Lai, Jun S., M. Na’im Mohamad Ayob, Shirong Cai, et al. "Maternal plasma vitamin B12 concentrations during pregnancy and infant cognitive outcomes at 2 years of age." British Journal of Nutrition 121, no. 11 (2019): 1303–12. http://dx.doi.org/10.1017/s0007114519000746.

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AbstractEvidence on long-term influences of maternal vitamin B12 deficiency or concentrations on infant cognition is limited. We examined associations between maternal plasma vitamin B12 and cognitive development in 24-month-old infants. Maternal plasma vitamin B12 concentrations were measured at 26–28 weeks’ gestation; infant cognitive development was assessed with the Bayley Scales of Infant and Toddler Development-III at 24 months, for 443 mother–infant pairs from the Growing Up in Singapore Towards Healthy Outcomes cohort. Linear regressions adjusted for key confounders examined associatio

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Mozos, Ioana, Dana Stoian, and Constantin Tudor Luca. "Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness." Disease Markers 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8784971.

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Arterial stiffness is associated with cardiovascular risk, morbidity, and mortality. The present paper reviews the main vitamins related to arterial stiffness and enabling destiffening, their mechanisms of action, providing a brief description of the latest studies in the area, and their implications for primary cardiovascular prevention, clinical practice, and therapy. Despite inconsistent evidence for destiffening induced by vitamin supplementation in several randomized clinical trials, positive results were obtained in specific populations. The main mechanisms are related to antiatherogenic

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Mantle, David. "Nutritional supplementation for vitamin B12 and vitamin K2 deficiency following ileostomy or colostomy formation." Gastrointestinal Nursing 18, Sup4 (2020): S12—S16. http://dx.doi.org/10.12968/gasn.2020.18.sup4.s12.

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Most dietary vitamins and minerals are absorbed from the duodenal and jejunal sections of the small bowel. The exceptions are vitamin B12 and vitamin K2, which are absorbed from the terminal ileum and colon respectively. Patients who have undergone ileostomy or colostomy procedures are at risk of deficiency of these vitamins, with associated risk of developing anaemia and nervous system dysfunction (vitamin B12), and bone weakening and cardiovascular disease (vitamin K2). Patients should therefore be monitored for deficiency of these vitamins, which may develop over a protracted period of time

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Rezazadeh, Fahimeh, and Sara Haghighat. "Serum Vitamin Profile in Oral Lichen Planus Patients in Southwest of Iran." BioMed Research International 2021 (February 24, 2021): 1–7. http://dx.doi.org/10.1155/2021/8627435.

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Introduction. Oral lichen planus (OLP) is a chronic mucocutaneous disease. It is mainly an immune system-related disorder. Vitamins can modulate immune system functions, and thus, vitamin deficiency might have roles in exacerbating OLP. We aim to determine the serum levels of vitamins A, B12, C, D3, and E in OLP patients. Methods and Materials. 34 OLP patients referred to Shiraz Dental School entered the study. Blood samples were collected and levels of A, B12, C, D3, and E vitamins were measured in serum. 43 healthy people were also included as the control group. Serum levels of vitamins were

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El-Kholy, Mohamed Soliman, Zenat Abd El-Gawad Ibrahim, Mohamed Mamdoh El-Mekkawy, and Mahmoud Alagawany. "Influence of in Ovo Administration of Some Water-Soluble Vitamins on Hatchability Traits, Growth, Carcass Traits and Blood Chemistry of Japanese Quails." Annals of Animal Science 19, no. 1 (2019): 97–111. http://dx.doi.org/10.2478/aoas-2018-0041.

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AbstractA total of 450 fertile Japanese quail eggs were used to determine the impacts of in ovo administration of water-soluble vitamins (C, B6 and B12) on the growth performance, carcass traits, hematological and biochemical blood parameters as well as the immune response of Japanese quails. On the 7th day of incubation, the eggs were allocated to five groups: un-injected, 0.1 ml/egg saline, 1 mg/egg vitamin C, 150 µg/egg vitamin B6 and 20 µg/egg vitamin B12. The percentage of early embryonic mortality was increased (P≤0.001) in all treated groups versus the control group. Chicks that hatched

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Tagore, Praveen K., Prashant Harit, Manish K. Sachan, Mahendra K. Bharti, Pratima Singh, and Gauri Harit. "Effect of Vitamins B12 and D Deficiency in Thyroid, Skin, Oral, and Respiratory Disease." Journal of Pharmacy and Bioallied Sciences 17, Suppl 2 (2025): S1749—S1751. https://doi.org/10.4103/jpbs.jpbs_300_25.

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ABSTRACT Background: Vitamin B12 and vitamin D play crucial roles in maintaining metabolic and immune homeostasis. Deficiencies in these vitamins have been linked to multiple systemic and localized disorders, including thyroid dysfunction, dermatological conditions, oral pathologies, and respiratory diseases. Materials and Methods: A cross-sectional study was conducted on 200 participants aged 20–50 years, divided into two groups: individuals with vitamins B12 and D deficiencies (n = 100) and healthy controls (n = 100). Serum vitamin B12 and vitamin D levels were assessed using chemiluminescen

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Girard, C. L., and J. J. Matte. "Impact of B-vitamin supply on major metabolic pathways of lactating dairy cows." Canadian Journal of Animal Science 86, no. 2 (2006): 213–20. http://dx.doi.org/10.4141/a05-058.

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Knowledge of the major nutrient requirements of dairy cows has increased substantially during the past decades. Little is known, however, about the importance of the roles played by B vitamins. Since most of those vitamins act as essential cofactors in energy, protein and lipid metabolism, it is likely that as milk yield increases, the demand for these cofactors also increases. The supply of B vitamins from dietary sources and synthesis by the ruminal microflora is generally sufficient to avoid deficiency symptoms, but could be insufficient for optimizing metabolic efficiency, production, comp

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Angelopoulos, Nikolaos, Rodis D. Paparodis, Ioannis Androulakis, Anastasios Boniakos, and Sarantis Livadas. "Effects of a Novel Dispersible Supplement Containing 2500 IU of Vitamin D and 1000 µg of B12 in Restoring Vitamin D and B12 Insufficiency: A Multicenter, Randomized Controlled Trial." Nutrients 17, no. 3 (2025): 419. https://doi.org/10.3390/nu17030419.

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Background/Objectives: Vitamins D and B12 play a crucial role in maintaining bone health, immune function, and neurological integrity. Combined deficiencies in these vitamins can lead to severe health consequences. Current treatment approaches, such as dietary changes and single-vitamin supplementation, often fail to address these deficiencies comprehensively. This study evaluates the effectiveness of concurrent vitamin D and B12 supplementation to correct these insufficiencies. Methods: A prospective, multicenter, randomized controlled trial was conducted in Greece from October 2024 to Decemb

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Baltrusch, Simone. "The Role of Neurotropic B Vitamins in Nerve Regeneration." BioMed Research International 2021 (July 13, 2021): 1–9. http://dx.doi.org/10.1155/2021/9968228.

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Damage and regeneration naturally occur in the peripheral nervous system. The neurotropic B vitamins thiamine (B1), pyridoxine (B6), and cobalamin (B12) are key players, which maintain the neuronal viability in different ways. Firstly, they constantly protect nerves against damaging environmental influences. While vitamin B1 acts as a site-directed antioxidant, vitamin B6 balances nerve metabolism, and vitamin B12 maintains myelin sheaths. However, nerve injury occurs at times, because of an imbalance between protective factors and accumulating stress and noxae. This will result in the so-call

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Fahad Aldaihani, Saad. "VITAMIN DEFICIENCY AND FOOD SUPPLEMENTS." International Journal of Advanced Research 9, no. 12 (2021): 540–52. http://dx.doi.org/10.21474/ijar01/13941.

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Vitamins are a heterogeneous group of organic compounds that help ensure the human bodys wellbeing and function. This paper introduces the importance of all vitamins, both water-soluble and fat-soluble, as well as problems deriving from their deficiency. Additionally, vitamin supplements as part of treating vitamin deficiency, and possible harmful effects on the human body areshowcased. The main focus of the paper is on the vitamin B complex, and vitamin B12 specifically. The benefits of vitamin B12, as well as its action in the human body and the noxious effects of any lack of vitamin B12 in

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Ismael Ibrahim, Gulzar, Hemn Jameel Majeed, Pshtiwan Abdullah Yousif, and Saman Muhsin Abdulkareem. "Association between Serum Levels of Vitamin D, Vitamin B12 and Folate with Oxidative Biomarkers in Diabetic Type 2 Patients in People in Erbil City: A Case-Control Study." Diyala Journal of Medicine 19, no. 2 (2020): 200–207. http://dx.doi.org/10.26505/djm.19025660915.

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Background: Diabetes mellitus is the largest endocrine disorder in the world that refers to chronic hyperglycemia caused by impairment in both insulin secretion and action. Folate, vitamin B12, and vitamin D deficiency are related to the prevalence of type 2 diabetes mellitus. Objective: This study has been carried out to investigate the role of folate, vitamins B12, and D status during the progression of diabetic type 2 patients compared to non-diabetic control subjects. Patients and Methods: We measured the plasma levels of folate, vitamins B12, and D, along with blood glucose, HbA1c, and ox

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Hoffmann, Jessica, Stefan Busse, Franz von Hoff, Katrin Borucki, Thomas Frodl, and Mandy Busse. "Association Between Homocysteine and Vitamin Levels in Demented Patients." Journal of Alzheimer's Disease 81, no. 4 (2021): 1781–92. http://dx.doi.org/10.3233/jad-201481.

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Background: Although it is known that the nutritional status among elderly persons and, in particular, patients with dementia, is compromised, malnutrition that results in insufficient uptake of several vitamins is often not diagnosed. Objective: An elevated homocysteine level is a known strong risk factor for vascular dementia (VaD) and Alzheimer’s disease (AD). Several B vitamins are involved in the metabolism of homocysteine. Therefore, we investigated the serum levels of vitamin B1, vitamin B6, folate, and vitamin B12 in 97 patients with mild cognitive impairment (MCI) or different forms o

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Fenti, Fenti, Agustinus Widodo, and Jamaluddin Jamaluddin. "ANALYSIS OF VITAMIN B-COMPLEX OF EEL FISH (ANGUILLA MARMORATA (Q.) GAIMARD) ON ELVER PHASE ORIGIN LAKE POSO." Ghidza: Jurnal Gizi dan Kesehatan 2, no. 2 (2019): 49. http://dx.doi.org/10.22487/gjgk.v2i2.11321.

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Background & Objective: Vitamins are complex organic substances that are needed by the body in small amounts, usually cannot be synthesized by the body but are important in metabolic processes one of which is vitamin B. Vitamin B consists of vitamins B1, B2, B3, B6, B9 and B12. Eel is one of the fish that has a high nutrient content, one of which is vitamin B. This study aims to determine the levels of vitamin B (B1, B2, B3, B6, B9 and B12) in Eel fish (Anguilla marmorata (Q.) Gaimard) on Elver phase from Lake Poso. Material and Methods: Determination of vitamin B1, B2, B3, B6 and B9 using

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Cazacu, Nicoleta, Claudia G. Chilom, Melinda David, and Monica Florescu. "Conformational Changes in the BSA-LT4 Complex Induced by the Presence of Vitamins: Spectroscopic Approach and Molecular Docking." International Journal of Molecular Sciences 23, no. 8 (2022): 4215. http://dx.doi.org/10.3390/ijms23084215.

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Levothyroxine (LT4) is known for its use in various conditions including hypothyroidism. LT4 interaction with serum albumin may be influenced by the presence of vitamins. For this reason, we investigated the effect of vitamin C, vitamin B12, and folic acid on the complex of Bovine Serum Albumin with LT4 (BSA-LT4). UV-Vis spectroscopy was used to monitor the influence of vitamins on the BSA-LT4 complex. Fluorescence spectroscopy revealed a static quenching mechanism of the fluorescence of BSA-LT4 complex by the vitamin C and folic acid and a combined mechanism for vitamin B12. The interaction o

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Candito, Mirande, Bakhouche Houcher, François Roux та ін. "Influence of Meal on Plasma Folate and Vitamin Β12, by Three Methods - and on Vitamin B6, Homocysteine and Red Blood Cell Folate". Pteridines 16, № 1 (2005): 22–26. http://dx.doi.org/10.1515/pteridines.2005.16.1.22.

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Abstract Vitamins are brought by meals. Some of them are cofactors in homocysteine metabolism, and, if plasma homocysteine values are not known to have a circadian rhythm, little is known about meal influence on blood folate, and vitamins Β12 and B6. The aim of this study is to analyze the effect of breakfast and lunch on plasma folate, vitamins B12 and B6. homocysteine and red cell folate (RCF) in 13 subjects; and, in 6 of them, to compare plasma folate and vitamin Β12 values with three analytical methods. In the 13 subjects, folate, vitamins B12 and B6 and RCF were analyzed by RIA, homocyste

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Golovach, P. I., B. V. Gutyj, I. A. Kolomiiets, D. D. Ostapiv, R. S. Oseredchuk, and O. M. Sloboda. "The effect of B groups vitamins (B1, B2, B5, B6, B10, B12) on the activity of antioxidants protection system enzymes and the content of lipids peroxide oxidation products in the blood of feeding cattle." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 25, no. 112 (2023): 22–26. http://dx.doi.org/10.32718/nvlvet11203.

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The article highlights the specifics of the effect of various doses of a complex of B vitamins (B1, B2, B5, B6, B10, B12) on the activity of critical enzymes of the body's antioxidant defense system (superoxide dismutase, catalase, glutathione peroxidase) and the content of peroxide oxidation products (diene conjugates and Malan dialdehyde) in the blood of cattle at the final stage of fattening. The research was conducted during the winter-spring stall on 12-month-old Ukrainian black-spotted dairy cows. According to the principle of analogs, five groups of experimental animals (control and fou

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Yamada, Keiko, Michiko Shimodaira, Seiko Chida, et al. "Degradation of Vitamin B12 in Dietary Supplements." International Journal for Vitamin and Nutrition Research 78, no. 45 (2008): 195–203. http://dx.doi.org/10.1024/0300-9831.78.45.195.

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Beverages and solid dietary supplements rich in various added vitamins and minerals have recently become available. It seems reasonable to consider that the intake of these foods is convenient for easy ingestion of nutrients, but problems caused by blending different nutrients in high concentrations have arisen. We focused on vitamin B12 (B12) among vitamins and determinded the B12 contents of beverages and solid dietary supplements purchased from a retail shop. The B12 contents of three of five beverges were less than stated on the labels. On the other hand, certain beverages unexpectedly con

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Matte, J. J., F. Guay, and C. L. Girard. "Folic acid and vitamin B12 in reproducing sows: New concepts." Canadian Journal of Animal Science 86, no. 2 (2006): 197–205. http://dx.doi.org/10.4141/a05-059.

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In pig nutrition, the present gaps in the information on B-complex vitamins have important implications for empiricism and disparities in dietary recommendations. This is particularly true for folic acid (B9) and vitamin B12. Recent studies suggest that the beneficial effects of B9 on sow prolificacy may be due to enhanced embryo development and survival. Embryo synthesis of estrogens and uterine secretions of prostanoids and cytokines during attachment appear to be key factors in vitamin B9 regulation of embryo development. Nevertheless, embryo and uterine responses to B9 are often more prono

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Mihaljev, Željko, Milica Živkov Baloš, and Sandra Jakšić. "POSSIBILITY OF DETERMINING VITAMIN B12 IN VITAMIN PREMIXES AND FEED ADDITIVES USING AAS METHOD." Archives of Veterinary Medicine 1, no. 2 (2008): 75–80. http://dx.doi.org/10.46784/e-avm.v1i2.233.

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Since vitamin B12 has important metabolic functions, but is unable sufficiently to synthesize into organisms of domestic animals (especially non-ruminants), special attention is given to adding B12 into feed. The needs for this vitamin are provided through vitamin premixes, so determining the quantity of B12 in the samples is of utmost importance. When standard chemical methods are applied extraction and purification are required. In this paper is described a method where the content of B12 in premix with high level of different vitamins is determined through an indirect method: measuring the

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Ali, Zahra K., Eman Abbas Aboud, and Ammar Abdul Sattar Hamza. "A Cross-Sectional Study of Serum Levels of Several Vitamins in Healthy and Unhealthy Periodontal Conditions." South Asian Research Journal of Oral and Dental Sciences 6, no. 04 (2024): 45–49. http://dx.doi.org/10.36346/sarjods.2024.v06i04.002.

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Vitamins are examples of micronutrients, which are nutrients needed in very minute quantities. They're crucial to metabolism and keeping tissues working properly. The purpose of this study was to determine whether vitamin deficiencies are associated with an increased risk of periodontitis. There was a total of 110 participants: 55 with chronic periodontitis spread throughout the mouth and 55 periodontally healthy individuals. Clinical parameters that were assessed included: Clinical attachment loss (in millimetres) and gingival index (in millimetres). Vitamin B12, vitamin D, folate, as well as

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El-Shaheed, Azza Abd, Nermine N. Mahfouz, Mones M. Abushady, and Inas R. El-Alameey. "Relation of Serum Micronutrients to Growth and Nutritional Habits of School-Aged Children in Egypt." Biomedical and Pharmacology Journal 15, no. 2 (2022): 775–83. http://dx.doi.org/10.13005/bpj/2415.

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Proper growth of children depends on several micronutrients. A fundamental role of Zinc and vitamins as A, B12 and D is crucial to prevent a failure to thrive. To study the relationship between Egyptian school aged children growth, nutritional habits and micronutrients deficiencies. Materials and methods: A case control research involved 60 school aged children (age ranged from 6 to 12 years). Group 1 (malnourished) compared with group II (apparently healthy children of matched peers). Serum concentrations of Zinc, Copper, and vitamins as A, B12, and D were measured using ELISA kits. Compared

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Kaczkan, Małgorzata, Sylwia Czaja-Stolc, Małgorzata Szczuko, et al. "Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis." Nutrients 15, no. 2 (2023): 440. http://dx.doi.org/10.3390/nu15020440.

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The concentration of water-soluble vitamins (except folic acid and vitamin B12) is not routinely measured, which may lead to undiagnosed deficiencies among hemodialysis (HD) patients. The aim of the study was to assess the blood concentration of water-soluble vitamins in HD patients in comparison with healthy subjects and to assess the impact of diabetes mellitus (DM) coexistence on the concentration of these vitamins. The two-center study included 142 HD patients and a control group of 31 healthy subjects. Vitamins concentration was determined using high-performance liquid chromatography (HPL

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Harfiansyah, M. Deddy, Effendy De Lux Putra, and Siti Morin Sinaga. "Simultaneous Determination of Vitamins B1, B2, B3, B6, and B12 in Tablet Forms Using the Area Under the Curve Ultraviolet Spectrophotometry Method." International Journal of Research and Review 11, no. 12 (2024): 56–61. https://doi.org/10.52403/ijrr.20241206.

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This research focuses on creating the area under the curve (AUC) ultraviolet spectrophotometry method approach to assess the concentrations of vitamins B1, B2, B3, B6, and B12 in tablet formulations, bypassing the need for separation steps. The technique relies on calculating the AUC values across different concentrations within a specified wavelength range, using methanol as the solvent. Subsequently, the method was applied to evaluate the levels of these vitamins in the tablets. The analysis targeted specific wavelength ranges for each vitamin: 250-260 nm for B1, 279-289 nm for B2, 267-277 n

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Patino-Alonso, Maria C., Marta Gómez Sánchez, Leticia Gómez Sánchez, et al. "Multivariate Analysis of Influence of Vitamin Intake on Vascular Function Parameters by Sex in the General Spanish Population: EVA Study." Nutrients 12, no. 3 (2020): 643. http://dx.doi.org/10.3390/nu12030643.

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The influence of vitamin intake on vascular function parameters in the Spanish general population has not been studied. The main objective of this study is to analyze the influence of vitamin intake on vascular function and as a secondary objective the adequacy of vitamin intake in a sample of the Spanish population without previous cardiovascular disease and analyze the differences according to sex. Methods: We included 501 individuals obtained by simple random sampling with replacement (reference population 43,946). The average age was 55.90 ± 14.24 years, 49.70% men. Participants recorded t

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Pizova, N. V. "The role of neurotropic B vitamins in clinical practice." Meditsinskiy sovet = Medical Council, no. 21 (November 23, 2023): 116–21. http://dx.doi.org/10.21518/ms2023-403.

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B-group vitamins are a collection of 8 water-soluble vitamins. They are cofactors for many enzymes, as well as axonal transport, synthesis of neurotransmitters and other metabolic processes. Their function can be divided into catabolic metabolism, leading to energy production, and anabolic metabolism. Some B vitamins are considered neurotrophic and play a particularly important role in both the central and peripheral nervous systems. Neurotropic B-group vitamins (B1 – thiamine, B6 – pyridoxine and B12 – cyanocobalamin) play the role of modulators for the treatment of inflammation and pain, the

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Koprivica, Marko, Jelena Bjelanovic, and Radmila Velicki. "The effects of vitamin B12 deficiency." Medical review 74, no. 11-12 (2021): 391–95. http://dx.doi.org/10.2298/mpns2112391k.

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Vitamin B12 is one of the most important B vitamins. This vitamin has an important role in cellular metabolism and is also associated with folate and vitamin B6 metabolism. Vitamin B12 deficiency occurs as a result of some diseases, the use of certain medications, or inadequate nutrition. It primarily affects the elderly and women, but is also common among the pediatric population. The B12 deficiency mostly affects the functions of the nervous and hematopoietic systems but it can also affect the skin, heart, bones, and eyes. The treatment of vitamin B12 deficiency includes oral or intramuscula

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Liu, Xi-Xi, Peng-Fei Wu, Ying-Zi Liu, et al. "Association Between Serum Vitamins and the Risk of Alzheimer’s Disease in Chinese Population." Journal of Alzheimer's Disease 85, no. 2 (2022): 829–36. http://dx.doi.org/10.3233/jad-215104.

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Background: Alzheimer’s disease (AD) is a chronic and fatal neurodegenerative disease; accumulating evidence suggests that vitamin deficiency is associated with the risk of AD. However, studies attempting to elucidate the relationship between vitamins and AD varied widely. Objective: This study aimed to investigate the relationship between serum vitamin levels and AD in a cohort of the Chinese population. Methods: A total of 368 AD patients and 574 healthy controls were recruited in this study; serum vitamin A, B1, B6, B9, B12, C, D, and E were measured in all participants. Results: Compared w

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Pinzon, Rizaldy Taslim, Ester Novitasari, and Nining Sri Wuryaningsih. "Perbedaan Kadar Leukosit dan Limfosit Paska Pemberian Kombinasi Vitamin B Parenteral Pada Pasien Penyakit Ginjal Kronik dengan Hemodialisis." Jurnal Ilmiah Kedokteran Wijaya Kusuma 10, no. 1 (2021): 27. http://dx.doi.org/10.30742/jikw.v10i1.1083.

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Chronic kidney disease is a disease in which kidney function decreases progressively irreversibly with various etiologies. Patients with chronic kidney disease are generally immunosuppressed and susceptible to infection. Some of the causes are abnormalities in polymorphonuclear leukocytes and lymphocytes. The results of several studies indicate that patients undergoing hemodialysis have low levels of water-soluble vitamins. A decrease in the number of leukocytes can also occur due to a decrease in neutrophils and lymphocytes which may be caused by deficiency of vitamins B6 and B12 due to hemod

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Cuyubamba, Oscar, Camila Pereira Braga, Dionne Swift, John T. Stickney, and Christian Viel. "The Combination of Neurotropic Vitamins B1, B6, and B12 Enhances Neural Cell Maturation and Connectivity Superior to Single B Vitamins." Cells 14, no. 7 (2025): 477. https://doi.org/10.3390/cells14070477.

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Peripheral neuropathy (PN) is a prevalent condition characterized by damage to peripheral nerves, often linked to risk factors such as diabetes. This condition results from various forms of neural damage, including injury to the cell body, axons, or demyelination, frequently beginning with small and thinly or unmyelinated fibers. Such nerve damage disrupts normal signaling, leading to symptoms like numbness, tingling, and pain. Effective nerve repair and regeneration, particularly through remyelination, are essential therapeutic objectives. While vitamin B12’s role in repair processes has been

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Pavlyshyn, Halyna, and Oksana Labivka. "MICRONUTRIENT STATUS IN CHILDREN INFECTED WITH THE SARS-COV-2 VIRUS." Eastern Ukrainian Medical Journal 12, no. 4 (2024): 788–97. https://doi.org/10.21272/eumj.2024;12(4):788-797.

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The coronavirus disease (COVID-19) caused by SARS-CoV-2 has raised significant public health concerns, leading to varying degrees of respiratory illness. Vitamins A, D, B6, B9, and B12 are essential for immune responses to viral infections, including COVID-19, while homocysteine, regulated by B vitamins, may affect inflammatory reactions and vascular complications. This study aimed to assess the levels of these micronutrients and homocysteine in children with COVID-19, exploring potential links to disease severity. Materials and Methods: The study, included 112 children with COVID-19 and 23 he

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Ghanim, Waleed K., and Nada N. Al-Shawi. "Evaluating the Effects of Different Doses of Vitamin B2 and Single Dose of Vitamin B12 Against Myelosuppression Induced by Cyclophosphamide in Experimental Rats." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 29, no. 1 (2020): 134–42. http://dx.doi.org/10.31351/vol29iss1pp134-142.

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Cyclophosphamide is chemotherapeutic agent that utilized for the treatment of different malignancies; however its’ used associated with numerous adverse effects. Vitamin B2 and vitamin B12 suggested having myeloprotective effect. This work is designed to investigate the myeloprotective effect of both vitamins against cyclophosphamide induced myelosuppression. One hundred adult rats of both sexes were used in this study. The animals were randomly enrolled into ten groups of 10 rats each. Group I: Control group. Group II: Cyclophosphamide-treated. Group III and Group IV Orally-administered vitam

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Onibala, Aurelia R., Christi D. Mambo, and Angelina S. R. Masengi. "Peran Vitamin dalam Penanganan Penyakit Parkinson." JURNAL BIOMEDIK (JBM) 13, no. 3 (2021): 322. http://dx.doi.org/10.35790/jbm.13.3.2021.31956.

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Abstrak: Penyakit Parkinson atau Parkinson’s disease (PD) merupakan penyakit neurodegeneratif yang bersifat kronis, progresif, dan tidak dapat disembuhkan sehingga penyakit ini memiliki dampak sosial yang besar. Pengobatan yang digunakan saat ini tidak dapat menghentikan perjalanan PD dan memiliki efek samping yang merugikan. Oleh sebab itu diperlukan terapi tambahan dengan risiko efek samping yang lebih rendah seperti vitamin. Penelitian ini bertujuan untuk mengetahui vitamin apa saja yang berperan dan bagaimana mekanisme peran vitamin tersebut dalam membantu penanganan PD. Penelitian ini dil

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Sikdar, K. M. Yasif Kayes, Md Khairul Islam, Tomislav Sostaric, Lee Yong Lim, and Cornelia Locher. "Development and Validation of a Quantitative Analysis of Water-Soluble Vitamins Using High-Performance Thin-Layer Chromatography and Its Application to the Analysis of Nutraceuticals." Separations 11, no. 7 (2024): 207. http://dx.doi.org/10.3390/separations11070207.

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In this study, a high-performance thin-layer chromatography (HPTLC)-based method was developed for the quantification of five water-soluble vitamins, B2, B3, B6, B12, and C, using ethanol–water (70:30, v/v) as the mobile phase. The method was validated according to the International Conference on Harmonisation (ICH) guidelines and the limits of detection/limits of quantification were determined as 5.27/15.97 ng (Vitamin B2), 13.03/39.47 ng (Vitamin B3), 59.61/180.64 ng (Vitamin B6), 14.17/42.93 ng (Vitamin B12), and 119.27/361.42 ng (Vitamin C) per band, respectively. The usefulness of the val

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Sami, Rokayya, Yang Li, Baokun Qi та ін. "HPLC Analysis of Water-Soluble Vitamins (B2, B3, B6, B12, and C) and Fat-Soluble Vitamins (E, K, D, A, andβ-Carotene) of Okra (Abelmoschus esculentus)". Journal of Chemistry 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/831357.

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Okra is consumed as a vegetable by populations in Africa and Asia and particularly in Egypt. In this study, we investigated some nutritional components of okra grown in four different geographical locations of Egypt. A comparative analysis of water-soluble vitamins (B2, B3, B6, B12, and C) and fat-soluble vitamins (E, K, D, A, andβ-carotene) in okra pods was carried out. Results of principal component analysis (PCA) showed three clusters of varieties. The first cluster included the Dakahlia (D) and Kafr El-Sheikh (K) varieties. The second and the third clusters separated out the Suez (S) and M

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Litvyak, Vladimir V., Svetlana T. Bykova, Yuri F. Roslyakov, and Lidia B. Kuzina. "SAFE FOOD FOR PATIENTS WITH PHENYLKETONURIA: AN INNOVATIVE METHOD OF PRODUCING PROTEIN-FREE PASTA PRODUCTS." Siberian Journal of Life Sciences and Agriculture 14, no. 1 (2022): 380–403. http://dx.doi.org/10.12731/2658-6649-2022-14-1-380-403.

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Background. At the moment, there is only a little information about the formulations of protein-free food products. Therefore, developing innovative methods of obtaining protein-free pasta is relevant for medicine and dietetics. The object of study. Phenylketonuria, pasta from native starches, extrusion starches, dried fruit puree, modified cellulose, gum, free amino acids, vitamins, minerals, salt. Results. The article, for the first time, proposes an original method for the production of pasta with low protein content, including dough preparation, shaping, and drying, which diffe

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Baker, Herman, Sanford M. Schor, Brian D. Murphy, Barbara DeAngelis, Susan Feingold, and Oscar Frank. "Blood vitamin and choline concentrations in healthy domestic cats, dogs, and horses." American Journal of Veterinary Research 47, no. 7 (1986): 1468–71. https://doi.org/10.2460/ajvr.1986.47.07.1468.

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SUMMARY Blood concentrations of thiamin, biotin, nicotinates, pantothenates, folates, riboflavin, vitamins A, B6, B12, C, E, β-carotene and choline were analyzed in healthy animals (23 horses, 25 dogs, and 29 cats). B-Complex vitamins and choline also were analyzed in the liver of the dogs and cats. Vitamin concentrations in the blood and livers of dogs were similar; however, blood vitamin A and β-carotene concentrations were lower in the cat than in the dog. Horses had a higher B12 blood concentration than did the dogs and cats. These data can be useful for detecting overt and hidden vitamin

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Zhizhin, N. A. "Determination of vitamin B12 in dry mixtures for baby food by the method of high performance liquid chromatography with chromatomass-spectrometric detection." Agrarian science, no. 5 (June 17, 2022): 132–36. http://dx.doi.org/10.32634/0869-8155-2022-359-5-132-136.

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Relevance. Vitamin B12 (cobalamin) belongs to the group of water-soluble vitamins. This vitamin belongs to the class of tetrapyrroles, biologically active substances consisting of pyrrole rings associated with metal ions. So, in the vitamin B12 molecule, the core is the cobalt ion. A feature of this vitamin is that its synthesis in nature is carried out only by bacteria, and therefore, it is present only in products of animal origin. And one of the sources of its receipt is milk and dairy products, including those enriched with B vitamins. Low concentrations of vitamin B12, even in vitamin-enr

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Koprivica, Marko, and Jelena Bjelanović. "Hypervitaminosis B12." Medicinski casopis 55, no. 4 (2021): 139–43. http://dx.doi.org/10.5937/mckg55-33665.

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Increased concentrations of vitamin B12 are the result of excessive intake of this vitamin, increased release of vitamins from hepatic depots, or elevated concentrations of transcobalamin resulting from the increased production or reduced decomposition of this molecule. The most common diseases that lead to B12 hypervitaminosis are malignancies and solid tumours. As a result of elevated concentrations, acnes emerge or exacerbate the already existing acneiform changes. Rosacea fulminant, allergic, and other anaphylactic reactions may also develop. The aim of the study was to determine the effec

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Iyer, Sandhya, Prachi Sinkar, K. Krishnakumar, Kallathikumar K, and Amruta Velumani. "Vitamin B Complex and Homocysteine Levels - A Trend Study Among Asian Indians." Asian Journal of Medical Sciences 10, no. 4 (2019): 14–18. http://dx.doi.org/10.3126/ajms.v10i4.24124.

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Background: Vitamin B complex levels have been strongly correlated with homocysteine status and many studies suggest supplementation with vitamin B to lower cardiovascular risk among adults. However, this relationship does not show a direct trend with many studies concluding otherwise. Aims and Objective: Our report is an attempt to study association between levels of vitamin B6, folate and B12 in relation to homocysteine in a Pan-India cohort of over 5000 individuals.  Materials & Methods: Data from a total of 5487 Asian Indians including 2942 males and 2545 females were consi

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Shavlovskaya, O. A., and I. A. Bokova. "Vitamins B Effectiveness in Different Nosological Forms." Effective Pharmacotherapy 19, no. 1 (2023): 40–47. http://dx.doi.org/10.33978/2307-3586-2023-19-1-40-47.

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B vitamins deserve special attention because they take an active part in the regulation of almost all systems activity, have a neurotropic effect. Among all B vitamins, the most actively used are B1 (thiamine), B6 (pyridoxine), B12 (cobalamin), which are prescribed both in monotherapy and in combination, intramuscularly or orally. Other B vitamins are rarely used alone, only in combination with other vitamins or biologically active supplements (dietary supplements). Thiamine is responsible for the metabolism of nerve tissues, the production of acetylcholine, which participates in carbohydrate

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Kazamia, Elena, Katherine E. Helliwell, and Alison G. Smith. "Keeping a clear head with vitamin B12." Biochemist 32, no. 6 (2010): 20–24. http://dx.doi.org/10.1042/bio03206020.

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Vitamins are vital organic micronutrients that are required in our diet because they provide essential enzyme cofactors, and animals have dispensed with the ability to synthesize them. Vitamin B12, or cobalamin, is the most complex of the vitamins, and the elucidation of its physiological role, its structure and its biosynthetic pathways have been the subject of impressive scientific endeavours over the years. Vitamin B12 deficiency leads to increased risk of cardiovascular disease, neurological symptoms and, in the most serious cases, pernicious anaemia. Cobalamin is synthesized only by proka

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Zhang, Chenbo, Jianfeng Luo, Changzheng Yuan, and Ding Ding. "Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis." Journal of Alzheimer's Disease 77, no. 2 (2020): 781–94. http://dx.doi.org/10.3233/jad-200534.

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Background: Previous studies have indicated that B vitamin deficiencies are an essential cause of neurological pathology. There is a need to provide evidence of the benefit of B vitamins for the prevention of cognitive decline in community-dwelling older adults. Objective: To examine the association between intake and plasma levels of vitamins B12, B6, and folate and cognitive function in older populations through a systematic review and meta-analysis. Methods: Medline (PubMed), EMBASE, and Cochrane databases were used to search the literature though August 8, 2019. We included observational p

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Yadav, Roopesh Kumar, Sudhanshu Mishra, and Deepti Jain. "Methylcobalamine (Vitamin B12): Water Soluble Vitamin with Various Pharmacological Aspect." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 130–37. http://dx.doi.org/10.22270/jddt.v11i1.4488.

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Vitamin B12 is a water-soluble vitamin that plays a key role in the brain's proper functioning and nervous system, in blood flow, and in reducing weakness and tiredness. In their food, most people get adequate vitamin B12, but in some health conditions (e.g. inadequate sleep, stomach/intestinal disorders, inflammation, cancer), there could be a shortage. If left unchecked, severe Vitamin B12 deficiency results in anemia and nerve damage. Vitamin B12 deficiency is typically treated using parenteral and oral dosage formulations, but absorption and compliance problems are involved with these rout

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Brasky, Theodore M., Emily White, and Chi-Ling Chen. "Long-Term, Supplemental, One-Carbon Metabolism–Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort." Journal of Clinical Oncology 35, no. 30 (2017): 3440–48. http://dx.doi.org/10.1200/jco.2017.72.7735.

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Purpose Inconsistent findings have been reported of a link between the use of one-carbon metabolism–related B vitamins and lung cancer risk. Because of the high prevalence of supplemental vitamin B use, any possible increased association warrants further investigation. We examined the association between long-term use of supplemental B vitamins on the one-carbon metabolism pathway and lung cancer risk in the Vitamins and Lifestyle (VITAL) cohort, which was designed specifically to look at supplement use relative to cancer risk. Methods A total of 77,118 participants of the VITAL cohort, 50 to

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Sherief, Laila M., Sanaa M. Abd El-Salam, Naglaa M. Kamal, et al. "Nutritional Biomarkers in Children and Adolescents with Beta-Thalassemia-Major: An Egyptian Center Experience." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/261761.

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Background and Aim. Trace elements and vitamins play a vital role in human body to perform its function properly. Thalassemic patients are at risk of micronutrient deficiency. This study estimated levels of vitamins A, C, E, B12, folic acid, total homocysteine (tHcy), and methylmalonic acid (MMA) along with trace elements, zinc, copper, and selenium in Beta-thalassemia-major patients.Methods. This study included 108 patients with Beta-thalassemia-major and 60 age and sex matched healthy children. Serum levels of vitamin A, E, C, tHcy, and MMA were estimated by high pressure liquid chromatograp

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Mbadiwe, Nkeiruka Chigekwu, Uchechi Maryrose Michael, Prince Henry Nnadi, Chidiebere Ikechukwu Ikaraoha, Chizaram Winners Ndubueze, and Vivian Ihechikwadorom Njoku. "Evaluation of Serum Levels of Some Water-Soluble Vitamin B Complexes in Cardiovascular Disease Patients." International Journal of Biochemistry Research & Review 33, no. 7 (2024): 8–15. http://dx.doi.org/10.9734/ijbcrr/2024/v33i7896.

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This study was carried out to investigate the serum levels of water-soluble vitamin B complexes (vitamin B3, vitamin B6, vitamin B9 and vitamin B12) in patients with cardiovascular diseases attending Cardiac Clinic at ESUTH Enugu State. Blood samples were obtained using the venipuncture technique from twenty cardiovascular disease patients, consisting of ten male and ten female patients. They were aged-matched with ten male and ten female controls, respectively. The serum concentrations of vitamins B3, B6, B9 and B12 were estimated using the titration methods for B3 and B6 and spectrophotometr

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Uktamova, Gulirano Dilmurodovna, and Charos Akhmatovna Rayimkulova. "THE ROLE AND IMPORTANCE OF VITAMIN B12 IN THE BODY." Research and implementation 2, no. 3 (2024): 169–72. https://doi.org/10.5281/zenodo.10780848.

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Currently, vitamins are one of the most important substances for the human body. Including Vitamin B 12 is one of the necessary and necessary vitamins for the body. It participates in the formation of erythrocytes, the formation of neurons and DNA synthesis. Deficiency of this vitamin leads to certain pathological causes in any organism

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Manapurath, Rukman, Ranadip Chowdhury, Sunita Taneja, Tor Strand, and Nita Bhandari. "Effect of Folate and/or Vitamin B12 Supplementation between 6 to 30 Months of Age on Markers of Cardiovascular Illness at School Age: A Secondary Analysis." Current Developments in Nutrition 6, Supplement_1 (2022): 927. http://dx.doi.org/10.1093/cdn/nzac067.047.

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Abstract Objectives Deficiencies of vitamin B12 and folate in childhood are associated with cardiovascular risk in later life. The main objective of this analysis is to measure the effect of vitamin B12 and/or folic acid supplementation in children between 6 to 30 months of age on biochemical markers of cardiovascular risk at school age. Methods This is a follow-up study of a randomized, 2 × 2 factorial, double-blind, placebo-controlled trial which assessed the effect of 2 recommended daily allowances of vitamin B12 and/or folic acid supplementation for 6 months on the risk of common infection

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