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1

Lange, Dirk, and Kymora B. Scotland, eds. The Role of Bacteria in Urology. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-17542-9.

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Lange, Dirk, and Ben Chew, eds. The Role of Bacteria in Urology. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-17732-8.

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3

Bacterial secreted proteins: Secretory mechanisms and role in pathogenesis. [Wymondham]: Caister Academic Press, 2009.

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4

Conway, Noellette Mary. The nutritional role of endosymbiotic bacteria in animal-bacteria symbioses: Solemya velum, a case study. Woods Hole, Mass: Woods Hole Oceanographic Institution, 1990.

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5

Mojgani, Naheed, and Maryam Dadar, eds. Probiotic Bacteria and Postbiotic Metabolites: Role in Animal and Human Health. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-0223-8.

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6

Lewis, Fraser John. Investigations of bacteria on building stone and their role in stone decay. Portsmouth: Portsmouth Polytechnic, School of Biological Sciences, 1987.

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7

Workshop on the Role of Anaerobic Bacteria in Infections of the Upper Respiratory Tract--Head and Neck (1988 Pittsburgh, Penn.). Workshop on the Role of Anaerobic Bacteria in Infections of the Upper Respiratory Tract-Head and Neck. Edited by Bluestone Charles D. 1932-, Klein Jerome O. 1931-, and Scheetz Mary D. St. Louis, MO: Annals Pub. Co., 1991.

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8

Lue-Mbizvo, Carmel. The role of women in small-scale bread, brick, and beer industries in rural Zimbabwe. Harare: Zimbabwe Environmental Research Organisation, 1991.

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9

Lue-Mbizvo, Carmel. The role of women in small-scale bread making, brick making, and beer brewing industries in rural Zimbabwe: Summary of findings. Harare: Zimbabwe Environmental Research Organisation, 1991.

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10

Office, General Accounting. Food safety: USDA's role under the National Residue Program should be reevaluated : report to the Chairman, Human Resources and Intergovernmental Relations Subcommittee, Committee on Government Operations, House of Representatives. Washington, D.C: The Office, 1994.

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11

Yamada, Masahiko. Studies on roles of lactic acid bacteria and yeast in the flavor of bakery products. 1988.

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12

Lange, Dirk, and Ben Chew. The Role of Bacteria in Urology. Springer, 2016.

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13

Lange, Dirk, and Ben Chew. The Role of Bacteria in Urology. Springer, 2015.

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14

Tripathi, Keshawanad, and Narendra Singh Rathore. Role of Photosynthetic Microbes in Agriculture and Industry. Nova Science Publishers, Incorporated, 2018.

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15

R, Gibson Glenn, and Macfarlane George T, eds. Human colonic bacteria: Role in nutrition, physiology, and pathology. Boca Raton: CRC Press, 1995.

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16

Hillman, Bradley. Role of gut bacteria in human toxicology and pharmacology. CRC Press, 2014. http://dx.doi.org/10.1201/9781482272482.

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17

Gibson, Glenn R. Human Colonic Bacteria: Role in Nutrition, Physiology, and Pathology. CRC Press, 1995.

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18

J, Hill M., ed. Role of gut bacteria in human toxicology and pharmacology. London: Taylor & Francis, 1995.

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19

Kirchman, David L. Degradation of organic matter. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789406.003.0007.

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The aerobic oxidation of organic material by microbes is the focus of this chapter. Microbes account for about 50% of primary production in the biosphere, but they probably account for more than 50% of organic material oxidization and respiration (oxygen use). The traditional role of microbes is to degrade organic material and to release plant nutrients such as phosphate and ammonium as well as carbon dioxide. Microbes are responsible for more than half of soil respiration, while size fractionation experiments show that bacteria are also responsible for about half of respiration in aquatic habitats. In soils, both fungi and bacteria are important, with relative abundances and activity varying with soil type. In contrast, fungi are not common in the oceans and lakes, where they are out-competed by bacteria with their small cell size. Dead organic material, detritus, used by microbes, comes from dead plants and waste products from herbivores. It and associated microbes can be eaten by many eukaryotic organisms, forming a detritus food web. These large organisms also break up detritus into small pieces, creating more surface area on which microbes can act. Microbes in turn need to use extracellular enzymes to hydrolyze large molecular weight compounds, which releases small compounds that can be transported into cells. Fungi and bacteria use a different mechanism, “oxidative decomposition,” to degrade lignin. Organic compounds that are otherwise easily degraded (“labile”) may resist decomposition if absorbed to surfaces or surrounded by refractory organic material. Addition of labile compounds can stimulate or “prime” the degradation of other organic material. Microbes also produce organic compounds, some eventually resisting degradation for thousands of years, and contributing substantially to soil organic material in terrestrial environments and dissolved organic material in aquatic ones. The relationship between community diversity and a biochemical process depends on the metabolic redundancy among members of the microbial community. This redundancy may provide “ecological insurance” and ensure the continuation of key biogeochemical processes when environmental conditions change.
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20

(Editor), Matthew K. Waldor, David I. Friedman (Editor), and Sankar Lal Adhya (Editor), eds. Phages: Their Role In Bacterial Pathogenesis And Biotechnology. ASM Press, 2005.

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21

Superantigens: Molecular basis for their role in human diseases. Washington, DC: ASM Press, 2007.

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22

(Editor), Malak Kotb, and John D. Fraser (Editor), eds. Superantigens: Molecular Basis for Their Role in Human Diseases. ASM Press, 2007.

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23

Dalziel, Robert Ian Ralph. The role of planktonic heterotrophic bacteria in lake ecosystem trophic dynamics. 1985.

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24

Manual for the Determination of the Clinical Role of Anaerobic Microbiology. Taylor & Francis Group, 2017.

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25

(Editor), Jorge H. Crosa, Alexandra R. Mey (Editor), and Shelley M. Payne (Editor), eds. Iron Transport In Bacteria: Molecular Genetics, Biochemistry, And Role In Pathogenicity And Ecology. ASM Press, 2004.

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26

Johnsson, Anna. The Role of Bioligands in Microbe-Metal Interactions: Emphasis on Subsurface Bacteria and Actinides. Goteborg University, 2006.

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27

Fong, I. W. The Role of Microbes in Common Non-Infectious Diseases. Springer, 2014.

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28

Lavermicocca, Paola, Joaquin Bautista-Gallego, and Cristina Reguant, eds. Lactic Acid Bacteria within the Food Industry: What is New on their Technological and Functional Role. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-294-6.

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29

Arriagada, Gabriel, Josefina Leon-Felix, Rafael Vignoli, and Gabriel Gutkind, eds. Antimicrobial Resistance in Zoonotic Bacteria in Developing Countries: The Role of Food Animal Production in Public Health. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-123-9.

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30

Anpanman to Baikinman. 2014.

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31

R, Demuth Donald, and Lamont Richard J. 1961-, eds. Bacterial cell-to-cell communication: Role in virulence and pathogenesis. Cambridge: Cambridge University Press, 2006.

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32

Minnick, Michael F. The role of the bacteria-induced M13 lectin in the immune response of the tobacco hornworm (Manduca sexta). 1987.

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33

author, Wakeford Alex, ed. Your baby's microbiome: The critical role of vaginal birth and breastfeeding for lifelong health. Chelsea Green Publishing, 2017.

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34

The Role of Biofilms in Device-Related Infections (Springer Series on Biofilms Book 3). Springer, 2008.

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35

(Editor), Donald R. Demuth, and Richard Lamont (Editor), eds. Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis (Advances in Molecular and Cellular Microbiology). Cambridge University Press, 2006.

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36

The Role of Biofilms in DeviceRelated Infections Springer Series on Biofilms. Springer, 2009.

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37

Bañuls, Anne-Laure, Thi Van Ahn Nguyen, Quang Huy Nguyen, Thi Ngoc Anh Nguyen, Hoang Huy Tran, and Sylvain Godreuil. Antimicrobial resistance: the 70-year arms race between humans and bacteria. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789833.003.0006.

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Antimicrobial resistance started to become a human health issue in the 1940s, following the discovery of the first antibiotics. The golden age of antibiotics (the 1950s through 1970s) marked the beginning of the arms race between humans and bacteria. Antimicrobial resistance is now among the greatest threats to human health; occurring in every region of the world and with the potential to affect anyone, anywhere. We describe the main mechanisms of antimicrobial resistance, as well as how the bacteria evolve into “superbugs.” We detail the role of human activities on the emergence and spread of highly drug-resistant bacteria. Currently, data to identify the specific causes, and to establish the baseline in low-income countries, are lacking. Because of the continual increase of multidrug resistance, the situation is urgent. The chapter ends with a view to the future, with a discussion of the specific problems of low-income countries and initiatives taken.
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38

Breban, Maxime, and Hill Gaston. Immune mechanisms: adaptive immunity. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198734444.003.0008.

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The role of adaptive immunity (i.e. the involvement of B and T lymphocytes) in the pathogenesis of axial spondyloarthritis has been investigated in both human disease and relevant animal models. Studies of B cell responses have not generally implicated an autoantibody in the disease, but there are abnormalities of antibody responses, particularly increased titres of antibodies to various gut bacteria. T cells are critical to the disease in animal models other than those where overexpression of a cytokine is engineered, suggesting that they are the drivers of the inflammatory response. There is convergent evidence from animal models, genetics in humans, and direct observation of human peripheral blood and joints to implicate T cells producing IL-17 under the influence of IL-23. These in turn may be responding to bacteria either in the gut or on the skin.
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39

Figdor, Carrie. Cases. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198809524.003.0002.

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Chapter 2 begins to illustrate the problem with details of recent scientific research into plants and bacteria and the uses of psychological predicates to describe the new discoveries. Plants are responsive to their environments in ways that have prompted researchers to ascribe learning, individuality, the ability to make choices, and other capacities to them. Bacterial colonies possess complex signaling mechanisms for communication and group decision-making. Individual bacteria, once considered mere bags of chemicals, have internal machinery that enables them to engage in signal transduction and information-processing. The chapter further articulates the role in the debate of the assumption that human mental capacities are the standard to which all other entities’ capacities are compared and found wanting. It begins to defend Literalism’s denial of this anthropocentrism of psychology. The growing evidence reveals how the burden of proof is shifting onto those to object to a default literal interpretation of psychological terms in the new domains.
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40

Keshav, Satish, and Alexandra Kent. Immunology and genetics in gastrointestinal and hepatic medicine. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0196.

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The gut has a pivotal role in immune homeostasis. It is constantly exposed to a wide array of antigens in food, and resident and consumed microorganisms. It is estimated that the number of bacterial cells in the gastrointestinal tract is tenfold greater than the number of cells in the human body. The gut needs to recognize harmful bacteria, and consequently contains the largest number of immune cells in the body. However, it must remain tolerant to commensal bacteria. Bacteria express antigens that stimulate an immunological response via the gut-associated lymphoid tissue (GALT). The GALT includes the appendix, tonsils, Peyer’s patches, and mesenteric lymph nodes. Therefore, the intestinal immune system is finely balanced between tolerance and reactivity. An example of an abnormal response that generally the individual should be tolerant to is gliadin peptides in coeliac disease. An example of excessive tolerance to an otherwise controllable infection is cryptosporidiosis, which causes diarrhoea in patients with HIV infection. The understanding of genetics in disease has progressed rapidly with the introduction of genome-wide association studies. The Welcome Trust Case Control Consortium has performed extensive research on the genetics of many illnesses, including Crohn’s disease, ulcerative colitis, Barrett’s oesophagus, oesophageal adenocarcinoma, and primary biliary cholangitis. Although these studies have increased our understanding of the molecular basis of disease, they have had little impact on clinical management. This may change as studies associate genotype and phenotype. Several gastrointestinal diseases have an etiology based on immunological or genetic aberrations, and these immunological mechanisms and genetic mutations can be utilized for diagnostic purposes. However, there is no genetic or immunological marker that is 100% specific to a disease and, consequently, the markers are used to support clinical, histological, and/or radiological findings.
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41

Kirchman, David L. Introduction to geomicrobiology. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789406.003.0013.

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Geomicrobiology, the marriage of geology and microbiology, is about the impact of microbes on Earth materials in terrestrial systems and sediments. Many geomicrobiological processes occur over long timescales. Even the slow growth and low activity of microbes, however, have big effects when added up over millennia. After reviewing the basics of bacteria–surface interactions, the chapter moves on to discussing biomineralization, which is the microbially mediated formation of solid minerals from soluble ions. The role of microbes can vary from merely providing passive surfaces for mineral formation, to active control of the entire precipitation process. The formation of carbonate-containing minerals by coccolithophorids and other marine organisms is especially important because of the role of these minerals in the carbon cycle. Iron minerals can be formed by chemolithoautotrophic bacteria, which gain a small amount of energy from iron oxidation. Similarly, manganese-rich minerals are formed during manganese oxidation, although how this reaction benefits microbes is unclear. These minerals and others give geologists and geomicrobiologists clues about early life on Earth. In addition to forming minerals, microbes help to dissolve them, a process called weathering. Microbes contribute to weathering and mineral dissolution through several mechanisms: production of protons (acidity) or hydroxides that dissolve minerals; production of ligands that chelate metals in minerals thereby breaking up the solid phase; and direct reduction of mineral-bound metals to more soluble forms. The chapter ends with some comments about the role of microbes in degrading oil and other fossil fuels.
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42

Food safety sourcebook: Basic consumer health information about the safe handling of meat, poultry, seafood, eggs, fruit juices, and other food items, and facts about pesticides, drinking water, food safety overseas, and the onset, duration, and symptoms of foodborne illnesses, including types of pathogenic bacteria, parasitic protozoa, worms, viruses, and natural toxins, along with the role of the consumer, the food handler, and the government in food safety; a glossary, and resources for additional help and information. Detroit, MI: Omnigraphics, 1999.

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43

Sirová, Dagmara, Jiří Bárta, Jakub Borovec, and Jaroslav Vrba. The Utricularia-associated microbiome: composition, function, and ecology. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198779841.003.0025.

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This chapter reviews current advances regarding plant–microbe interactions in aquatic Utricularia. New findings on the composition and function of trap commensals, based mainly on the advances in molecular methods, are presented in the context of the ecological role of Utricularia-associated microorganisms. Bacteria, fungi, algae, and protozoa colonize the Utricularia trap lumen and form diverse, interactive communities. The involvement of these microbial food webs in the regeneration of nutrients from complex organic matter is explained and their potential contribution to the nutrient acquisition in aquatic Utricularia is discussed. The Utricularia–commensal system is suggested to be a suitable model system for studying plant-microbe and microbe-microbe interactions and related ecological questions.
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44

Money, Nicholas P. 3. Microbial genetics and molecular microbiology. Oxford University Press, 2014. http://dx.doi.org/10.1093/actrade/9780199681686.003.0003.

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Cell structures and metabolic processes are specified by genes. The genomes of bacteria, archaea, and eukaryotic microorganisms are encoded in double-stranded helices of DNA. ‘Genetics and molecular microbiology’ explains that advances in sequencing techniques and the development of automated sequencing methods have allowed scientists to sequence the genomes of 4,000 bacterial genomes, 200 archaea, and 200 eukaryotes. Genome sizes vary a great deal within each category of microorganism and the largest prokaryote genomes overlap the smallest eukaryote genomes. Natural mutations in microorganisms play a primary role in evolution. Reproduction in prokaryotes is always asexual, whereas mechanisms of sexual reproduction have been studied in eukaryotic microorganisms belonging to all of the supergroups.
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45

Vigdor, Steven E. Randomness and Complexity. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198814825.003.0007.

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Chapter 7 describes the fundamental role of randomness in quantum mechanics, in generating the first biomolecules, and in biological evolution. Experiments testing the Einstein–Podolsky–Rosen paradox have demonstrated, via Bell’s inequalities, that no local hidden variable theory can provide a viable alternative to quantum mechanics, with its fundamental randomness built in. Randomness presumably plays an equally important role in the chemical assembly of a wide array of polymer molecules to be sampled for their ability to store genetic information and self-replicate, fueling the sort of abiogenesis assumed in the RNA world hypothesis of life’s beginnings. Evidence for random mutations in biological evolution, microevolution of both bacteria and antibodies and macroevolution of the species, is briefly reviewed. The importance of natural selection in guiding the adaptation of species to changing environments is emphasized. A speculative role of cosmological natural selection for black-hole fecundity in the evolution of universes is discussed.
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46

Sheppard, Charles R. C., Simon K. Davy, Graham M. Pilling, and Nicholas A. J. Graham. Microbial, microalgal and planktonic reef life. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198787341.003.0005.

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Microbes, including bacteria, archaea, viruses, fungi, protozoans and microalgae, are the most abundant and arguably the most important members of coral reef communities. They occur in the water column and sediment, and in association with other reef organisms. This chapter describes the abundance, diversity, function and productivity of microbes, with an emphasis on free-living types. They are key to recycling and retention of organic matter via the ‘microbial loop’, and are an important food source for larger reef organisms. The metazoan zooplankton are also described, including larvae of most reef invertebrates and fish. They are described in terms of their duration in the plankton, their settlement behaviour (e.g. that of coral larvae), their daily migration patterns and their role as a food source for larger organisms. Their importance for inter-reef connectivity is discussed.
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47

Figdor, Carrie. Pieces of Mind. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198809524.001.0001.

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Many people accept that chimpanzees, dolphins, and some other animals can think and feel. But these cases are just the tip of a growing iceberg. If biologists are right, fruit flies and plants make decisions, worms and honeybees can be trained, bacteria communicate linguistically, and neurons have preferences. Just how far does cognition go? This book is the first to critically consider this question from the perspective of the entire range of new ascriptions of psychological capacities throughout biology. It is also the first to consider the role of mathematical models and other quantitative forms of evidence in prompting and supporting the new ascriptions. It defends a default literal interpretation of psychological terms across biological domains. It also considers the implications of the literal view for efforts to explain the mind’s place in nature and for traditional ways of distinguishing the superior moral status of humans relative to other living beings.
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48

Thomas, David F. M. Vesicoureteric reflux. Edited by David F. M. Thomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0115.

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The term vesicoureteric reflux (VUR) describes the retrograde flow of urine from the bladder into the upper urinary tract. VUR is not a disease entity in its own right. Nevertheless, it has the potential to cause significant morbidity by preventing effective emptying of the urinary tract and by facilitating the transport of bacteria into the upper tract and renal parenchyma. Mechanisms of renal damage associated with VUR include pyelonephritic scarring and congenital dysplasia or hypoplasia. The long-term complications of pyelonephritic scarring may include hypertension, renal failure, and an increased risk of complications during pregnancy. VUR of mild or moderate severity is best managed conservatively and surgical intervention is generally reserved for failed medical management and high grade or complex VUR. Although the introduction of endoscopic correction has revolutionized surgical management, there remains a role for open surgery for the correction of higher grades of reflux.
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49

Stewart, Alex G., Sam Ghebrehewet, and Peter MacPherson. New and emerging infectious diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198745471.003.0026.

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This chapter describes the increasing global problem of new and emerging infections, many zoonotic, ranging from the recently described Middle East respiratory syndrome (MERS) to bacteria now resistant to all locally available antimicrobial agents. The environmental, human, technological, and microbial factors contributing to disease emergence are assessed. Changes in environment and land use result in the spread of vector-borne diseases into new areas, and global travel and trade may introduce pathogens to non-immune populations. The breakdown of health services following political change or during conflict can result in the resurgence of previously controlled communicable diseases. The importance of collaboration between human and veterinary health services is emphasized, and the UK ‘DATER’ strategy (Detection, Assessment, Treatment, Escalation, Recovery) for dealing with pandemic influenza is applied to new and emerging infections. Finally, the role of internet-based, syndromic surveillance to create early awareness of new infections is considered.
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50

Bunch, Chris. Splenomegaly and other disorders of the spleen. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0035.

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The spleen is a predominantly lymphoid organ, normally about the size of a clenched fist located beneath the diaphragm in the left upper abdomen. It has a dual role as a filter for the circulation, and a primary lymphoid organ in its own right. About three-quarters of its volume is a matrix of capillaries and sinuses (the red pulp), through which blood is able to percolate slowly and come into contact with fixed macrophages, which are able to remove senescent or damaged red cells, or other particulate matter such as bacteria. The lymphoid tissue is organized into scattered follicles (the white pulp), which have a particularly important role in initiating primary humoral immune responses and antibody (IgM) synthesis. The spleen commonly enlarges when either its filtration function is increased—as in haemolysis—or it is stimulated by infection or inflammation. It may also be involved in myeloproliferative and lymphoproliferative neoplasias. This chapter covers hypersplenism, splenectomy, hyposplenism, overwhelming post-splenectomy infection (OPSI), and other infections in hyposplenic patients.
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