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Journal articles on the topic 'Bacterial compounds'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Prashanthi Evangeline M, Prem Kumar P, and Bala Murugan K. "Cinnoline Derivatives as Antibacterial Agent and Antimycobacterial Agent: Synthesis, Microbial Evaluation and Molecular Docking Study." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 6675–84. http://dx.doi.org/10.26452/ijrps.v11i4.3588.

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Fourteen Novel cinnoline library compounds were designed, synthesized through a facile approach, and allowed for screening for anti-bacterial activity and anti-tubercular activity. The titled compounds were entirely synthesized by replacing alkyl groups, sulphonyl, halo groups in the 6th & 7th position of cinnoline moiety. The enlightenment of structure was done by FTIR HNMR along with elemental analysis and further docked for Structural activity. The newly synthesized Cinnoline Compounds were examined for their in vitro drug-sensitive M tuberculosis H37Hv strain. All the compounds have sh

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Aubey, Flore, Jean-Philippe Corre, Youxin Kong, et al. "Inhibitors of theNeisseria meningitidisPilF ATPase provoke type IV pilus disassembly." Proceedings of the National Academy of Sciences 116, no. 17 (2019): 8481–86. http://dx.doi.org/10.1073/pnas.1817757116.

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Despite the availability of antibiotics and vaccines,Neisseria meningitidisremains a major cause of meningitis and sepsis in humans. Due to its extracellular lifestyle, bacterial adhesion to host cells constitutes an attractive therapeutic target. Here, we present a high-throughput microscopy-based approach that allowed the identification of compounds able to decrease type IV pilus-mediated interaction of bacteria with endothelial cells in the absence of bacterial or host cell toxicity. Compounds specifically inhibit the PilF ATPase enzymatic activity that powers type IV pilus extension but re

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Shakir, Raied Mustafa, Shaimaa Abed Saoud, and Dhuha Faruk Hussain. "Synthesis, Antibacterial, and Molecular Docking Study of Novel 2-Chloro-8-Methoxy-3-Aryl-[1,3] Benzoxazine Derivatives using Vilsmeier Reagent." International Journal of Drug Delivery Technology 10, no. 03 (2020): 487–98. http://dx.doi.org/10.25258/ijddt.10.3.32.

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Reducing of ethyl 4-((2-hydroxy-3-methoxybenzylidene)amino)benzoate (1) afford ethyl 4-((2-hydroxy-3-methoxybenzyl)amino)benzoate (2). Reaction of this compound with Vilsmeier reagent affords novel 2-chloro-[1,3] benzoxazine ring (3). The corresponding acid hydrazide of compound 3 was synthesized from reaction of compound (3) with hydrazine hydrate. Newly series of hydrazones (5a–i) were synthesized from reaction of acid hydrazide with various aryl aldehydes. Antibacterial activity of the hydrazones was secerned utilizing gram-negative and gram-positive bacteria. Compound (5b) and (5c) exhibit

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García-Contreras, Rodolfo, Toshinari Maeda, and Thomas K. Wood. "Resistance to Quorum-Quenching Compounds." Applied and Environmental Microbiology 79, no. 22 (2013): 6840–46. http://dx.doi.org/10.1128/aem.02378-13.

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ABSTRACTBacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching co

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Teo, Stephen P., Sanjib Bhakta, Paul Stapleton, and Simon Gibbons. "Bioactive Compounds from the Bornean Endemic Plant Goniothalamus longistipetes." Antibiotics 9, no. 12 (2020): 913. http://dx.doi.org/10.3390/antibiotics9120913.

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The present study aimed to screen plants for bioactive compounds with potential antibacterial activities. In our efforts to evaluate plants from Borneo, we isolated and elucidated the structures of four natural products from the bioactive fraction of a chloroform extract of Goniothalamus longistipetes using various chromatographic and spectroscopic techniques. The bioactive compounds were identified as a known styryllactone, (+)-altholactone ((2S,3R,3aS,7aS)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahydrobenzo-5(4H)-5-one) (1), a new styryllactone, (2S,3R,3aS,7aS)-3-hydroxy-2-phenyl-2,3,3a,7a-tetrahyd

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Montenegro, Iván, Alejandro Madrid, Mauricio Cuellar, et al. "Biopesticide Activity from Drimanic Compounds to Control Tomato Pathogens." Molecules 23, no. 8 (2018): 2053. http://dx.doi.org/10.3390/molecules23082053.

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Tomato crops can be affected by several infectious diseases produced by bacteria, fungi, and oomycetes. Four phytopathogens are of special concern because of the major economic losses they generate worldwide in tomato production; Clavibacter michiganensis subsp. michiganensis and Pseudomonas syringae pv. tomato, causative agents behind two highly destructive diseases, bacterial canker and bacterial speck, respectively; fungus Fusarium oxysporum f. sp. lycopersici that causes Fusarium Wilt, which strongly affects tomato crops; and finally, Phytophthora spp., which affect both potato and tomato

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Uda, Narasimha Rao, and Marc Creus. "Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylasein Bacteria: The product of dapE-gene Is Not the Target ofl-Captopril Antimicrobial Activity." Bioinorganic Chemistry and Applications 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/306465.

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The emergence of bacterial strains that are resistant to virtually all currently available antibiotics underscores the importance of developing new antimicrobial compounds. N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) is a metallohydrolase involved in the meso-diaminopimelate (mDAP)/lysine biosynthetic pathway necessary for lysine biosynthesis and for building the peptidoglycan cell wall. Because DapE is essential for Gram-negative and some Gram-positive bacteria, DapE has been proposed as a good target for antibiotic development. Recently,l-captopril has been suggested as a lead co

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Gjorgjieva, Marina, Tihomir Tomašič, Danijel Kikelj, and Lucija Peterlin Mašič. "Benzothiazole-based Compounds in Antibacterial Drug Discovery." Current Medicinal Chemistry 25, no. 38 (2019): 5218–36. http://dx.doi.org/10.2174/0929867324666171009103327.

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Numerous compounds with a benzothiazole scaffold that have been described in the literature show promising activities against several Gram-positive and Gramnegative bacteria, and also against Mycobacterium tuberculosis. Benzothiazole-based antibacterial compounds bind to different biological targets in bacterial cells and have been shown to be inhibitors of enzymes that are important for essential processes in the bacterial cells, such as cell-wall synthesis, cell division, and DNA replication, or are important for different biosynthetic pathways of essential compounds in bacterial cells, such

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Audrain, Bianca, Mohamed A. Farag, Choong-Min Ryu, and Jean-Marc Ghigo. "Role of bacterial volatile compounds in bacterial biology." FEMS Microbiology Reviews 39, no. 2 (2015): 222–33. http://dx.doi.org/10.1093/femsre/fuu013.

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10

Stallforth, Pierre, Martin Klapper, Johannes Arp, and Markus Günther. "The Role of Bacterial Natural Products in Predator Defense." Synlett 29, no. 05 (2018): 537–41. http://dx.doi.org/10.1055/s-0037-1609226.

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Bacterially produced natural products, i.e., low molecular weight metabolites, or derivatives thereof, constitute most of the commercially available antibiotics as well as a large proportion of anticancer drugs. While indispensable as therapeutically active compounds, the ecological roles of many of these bacterial natural products remain poorly understood. Here, we discuss these metabolites in light of microbial predator defense: soil bacteria are constantly threatened by a variety of predators and the secretion of low molecular weight toxins enables the producing bacteria to kill or deter t

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Franco, Carlos Manuel, and Beatriz I. Vázquez. "Natural Compounds as Antimicrobial Agents." Antibiotics 9, no. 5 (2020): 217. http://dx.doi.org/10.3390/antibiotics9050217.

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During the first two decades of this century, conventional antimicrobial compounds have been found out to have more bacterial resistance. What has also been worrying is the rediscovery of the so-called “natural compounds”, which in turn have a good name among the average citizen because of the former’s plant or animal origin. However, they do not form a well-classified group of substances. This Special Issue consists of five reviews focusing on clinical bacteria applications in food and their specific effects upon virulent bacterial factors. You will also find a research on much needed, new an

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Koagne, Roméol Romain, Frederick Annang, Mercedes de la Cruz, et al. "Antibacterial Activity of Flavans from Crinum distichum." Natural Product Communications 13, no. 12 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301216.

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The phytochemical study of the ethanol extract from Crinum distichum Herb. was carried out using reversed phase high performance liquid chromatography and afforded a new natural flavan (1), along with (2 S)-4'-hydroxy-7-methoxyflavan (2), (2 R)-4'-hydroxy-5,7-dimethoxyflavan (3), hippadine (4) and hippacine(5). The structure of the new compound was elucidated using a combination of NMR and HRESI-MS analysis while the structures of the known compounds were established by comparison of their spectroscopic data with those of similar reported compounds. Compounds 2–5 also had moderate activity (32

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Mustafa M. AL-Hakiem, Rita S. Elias, and Munther A. Mohammed-Ali. "Synthesis, characterization and antibacterial evaluation of some sulfonamide Schiff base derivatives." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 3535–43. http://dx.doi.org/10.26452/ijrps.v10i4.1729.

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New series of Schiff base compounds obtained from sulfa drugs have been synthesized by the reaction of sulfonamide compounds (sulfadiazine, sulfapyridine, sulfamethazine, or sulfamerazine) with corresponding aromatic aldehydes (3-pyridinecarboxaldehyde or 4-pyridinecarboxaldehyde). The synthesized compounds were characterized by FT-IR, ESI-Mass, and 1H-NMR spectroscopy to confirm the chemical structures of synthesized compounds. The purity of all synthesized compounds were verified using pre-coated TLC (MERCK) plates using dichloromethane: methanol (9:1) solvent system. The chromatographic pla

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Feier, Andrei-Marian, Andrei-Constantin Ioanovici, Radu-Cristian Ionescu, Tamas Toth, and Octav-Marius Russu. "Biofilm Inhibition: Compounds with Antibacterial Effects." Journal of Interdisciplinary Medicine 3, no. 4 (2018): 234–38. http://dx.doi.org/10.2478/jim-2018-0042.

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Abstract Biofilms can form on living or inert surfaces and prevail in natural, industrial, and hospital environments. They are made of bacteria organized in a coordinated functional community. Biofilms do not respond to antibiotic treatment due to multiple mechanisms of tolerance and resistance. If bacteria are coordinated in a biofilm form, they are significantly less susceptible to antibiotics, thus making the therapeutic approach difficult. The possibility of using drugs aimed at inhibiting the formation of biofilms in combination with current antibiotics is a therapeutic approach with a ma

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Budumuru, Pushpalatha, Srinivasarao Golagani, and Venkata Siva Satyanaryana Kantamreddi. "DESIGN AND SYNTHESIS OF NOVEL IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR ANTI-BACTERIAL ACTIVITY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (2018): 252. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.26241.

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Objective: The present study aims to synthesize a novel derivatives of Imidazo[1,2-a]pyridines and the compounds were evaluated for their antibacterial activity.Methods: A series of newly synthesized compounds were characterized by 1H-nuclear magnetic resonance (NMR), 13C-NMR, Fourier transform infrared, mass spectral analysis, and screened for their antibacterial activity by disc diffusion method. Molecular docking studies were performed with a bacterial beta subunit of DNA gyrase using Auto Dock 4.2.6, and the docked conformations were analyzed using visual molecular dynamics.Results: The st

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Widiantini, Fitri, Ceppy Nasahi, Endah Yulia, and Serly Noviyawati. "Potensi Metabolit Sekunder Asal Bakteri Endofit dalam Menekan Pertumbuhan Miselium Ganoderma boninense." Jurnal Fitopatologi Indonesia 14, no. 3 (2018): 104. http://dx.doi.org/10.14692/jfi.14.3.104.

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Potency of Endophytic Bacterial Secondary Metabolite to Inhibit Mycelium Growth of Ganoderma boninense Endophytic bacteria have a close relationship with their host plants. The bacteria are living inside their host without causing any symptom. Endophytic bacteria are well known for their ability to produce compounds that can be used to protect plants from deleterious microorganisms. The research was conducted to determine the ability of endophytic bacteria in producing antifungal compounds that are able to suppress the growth of Ganoderma boninense, a causal agent of basal stem rot disease of

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González, Juan E., and Neela D. Keshavan. "Messing with Bacterial Quorum Sensing." Microbiology and Molecular Biology Reviews 70, no. 4 (2006): 859–75. http://dx.doi.org/10.1128/mmbr.00002-06.

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SUMMARY Quorum sensing is widely recognized as an efficient mechanism to regulate expression of specific genes responsible for communal behavior in bacteria. Several bacterial phenotypes essential for the successful establishment of symbiotic, pathogenic, or commensal relationships with eukaryotic hosts, including motility, exopolysaccharide production, biofilm formation, and toxin production, are often regulated by quorum sensing. Interestingly, eukaryotes produce quorum-sensing-interfering (QSI) compounds that have a positive or negative influence on the bacterial signaling network. This euk

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Ryandini, Dini, Hendro Pramono, and Sukanto Sukanto. "Antibacterial Activity of Streptomyces SAE4034 Isolated from Segara Anakan Mangrove Rhizosphere against Antibiotic Resistant Bacteria." Biosaintifika: Journal of Biology & Biology Education 10, no. 1 (2018): 117–24. http://dx.doi.org/10.15294/biosaintifika.v10i1.12896.

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Actinomycetes SAE4034 isolates was isolated from Rhizophora apiculata rhizosphere mud showed some antibacterial properties. The antibacterial ability of this isolate has not been tested on antibiotic resistant bacterial pathogens. However, there was no research has been reported regarding actinomycetes from Segara Anakan mangrove area resulting compounds inhibit the growth of antibiotics-resistant bacteria. Therefore, it is important to investigate its capability against antibiotics resistant bacteria or multi drug resistant bacteria (MDR bacteria). The research aimed to know the ability of ac

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Nau, Roland, and Helmut Eiffert. "Modulation of Release of Proinflammatory Bacterial Compounds by Antibacterials: Potential Impact on Course of Inflammation and Outcome in Sepsis and Meningitis." Clinical Microbiology Reviews 15, no. 1 (2002): 95–110. http://dx.doi.org/10.1128/cmr.15.1.95-110.2002.

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SUMMARY Several bacterial components (endotoxin, teichoic and lipoteichoic acids, peptidoglycan, DNA, and others) can induce or enhance inflammation and may be directly toxic for eukaryotic cells. Bactericidal antibiotics which inhibit bacterial protein synthesis release smaller quantities of proinflammatory/toxic bacterial compounds than Β-lactams and other cell wall-active drugs. Among the Β-lactams, compounds binding to penicillin-binding protein 2 (PBP-2) release smaller amounts of bacterial substances than antibacterials inhibiting PBP-3. Generally, high antibiotic concentrations (more th

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Seo, Jong-Su, Young-Soo Keum, and Qing Li. "Bacterial Degradation of Aromatic Compounds." International Journal of Environmental Research and Public Health 6, no. 1 (2009): 278–309. http://dx.doi.org/10.3390/ijerph6010278.

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Sakurai, I., Y. Kawamura, H. Koike, et al. "Bacterial Accumulation of Metallic Compounds." Applied and Environmental Microbiology 56, no. 8 (1990): 2580–83. http://dx.doi.org/10.1128/aem.56.8.2580-2583.1990.

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Khomami, Armin, Mohammadamin Rahimi, Arash Tabei, et al. "Synthesis and Docking Study of Novel 4-Thiazolidinone Derivatives as Anti-Gram-positive and Anti-H. pylori Agents." Mini-Reviews in Medicinal Chemistry 19, no. 3 (2019): 239–49. http://dx.doi.org/10.2174/1389557518666181017142630.

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Background: Bacterial resistance to the available antibiotics is a life threatening issue and researchers are trying to find new drugs to overcome this problem. Amongst the different structural classes, thiazolidinone-4-one, as a new effective pharmacophore against various bacteria, has been introduced. Objective: A new series of 2-(5-(5-nitrothiophene-2-yl)-1,3,4-thiadiazole-2-ylimino)-5-arylidenethiazolidin- 4-one derivatives were designed and synthesized as new antibacterial agents. Method: Target compounds were synthesized during 5 steps and their in vitro antibacterial and anti-H. pylori

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Ehlers, Ralf-Udo, and Jens Aumann. "Physico-chemical properties and mode of action of a signal from the symbiotic bacterium Photorhabdus luminescens inducing dauer juvenile recovery in the entomopathogenic nematode Heterorhabditis bacteriophora." Nematology 3, no. 8 (2001): 849–53. http://dx.doi.org/10.1163/156854101753625344.

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AbstractRecovery in entomopathogenic nematodes is the exit from the dauer juvenile stage. It is a response to environmental queues signalling the presence of food sources (e.g., insect haemolymph). The bacterium Photorhabdus luminescens excretes a signal which also induces recovery of its symbiotic Heterorhabditis bacteriophora dauer juveniles. This bacterial signal is composed of at least two compounds with different polarity. The symbiotic bacteria also secrete an antagonistic signal which inhibits nematode recovery. The recovery-inducing signal compounds have a molecular mass of less than 2

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Powers, Matthew J., Edgardo Sanabria-Valentín, Albert A. Bowers, and Elizabeth A. Shank. "Inhibition of Cell Differentiation in Bacillus subtilis by Pseudomonas protegens." Journal of Bacteriology 197, no. 13 (2015): 2129–38. http://dx.doi.org/10.1128/jb.02535-14.

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ABSTRACTInterspecies interactions have been described for numerous bacterial systems, leading to the identification of chemical compounds that impact bacterial physiology and differentiation for processes such as biofilm formation. Here, we identified soil microbes that inhibit biofilm formation and sporulation in the common soil bacteriumBacillus subtilis. We did so by creating a reporter strain that fluoresces when the transcription of a biofilm-specific gene is repressed. Using this reporter in a coculture screen, we identifiedPseudomonas putidaandPseudomonas protegensas bacteria that secre

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Malapaka, Venkata R. R., Albert A. Barrese, Brian C. Tripp, and Brian C. Tripp. "High-Throughput Screening for Antimicrobial Compounds Using a 96-Well Format Bacterial Motility Absorbance Assay." Journal of Biomolecular Screening 12, no. 6 (2007): 849–54. http://dx.doi.org/10.1177/1087057107304478.

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There is a pressing need to develop new antimicrobial drugs because of the increasing resistance of pathogenic bacteria to existing antibiotics. The preliminary development and validation of a novel methodology for the high-throughput screening of antimicrobial compounds and inhibitors of bacterial motility is described. This method uses a bacterial motility swarming agar assay, combined with the use of offset inoculation of the wells in a standard, clear, 96-well plate, to enable rapid screening of compounds for potential antibiotic and antimotility properties with a standard absorbance micro

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Weigert, Michael, and Rolf Kümmerli. "The physical boundaries of public goods cooperation between surface-attached bacterial cells." Proceedings of the Royal Society B: Biological Sciences 284, no. 1858 (2017): 20170631. http://dx.doi.org/10.1098/rspb.2017.0631.

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Bacteria secrete a variety of compounds important for nutrient scavenging, competition mediation and infection establishment. While there is a general consensus that secreted compounds can be shared and therefore have social consequences for the bacterial collective, we know little about the physical limits of such bacterial social interactions. Here, we address this issue by studying the sharing of iron-scavenging siderophores between surface-attached microcolonies of the bacterium Pseudomonas aeruginosa . Using single-cell fluorescence microscopy, we show that siderophores, secreted by produ

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Thappeta, Kishore Reddy Venkata, Li Na Zhao, Choy Eng Nge, et al. "In-Silico Identified New Natural Sortase A Inhibitors Disrupt S. aureus Biofilm Formation." International Journal of Molecular Sciences 21, no. 22 (2020): 8601. http://dx.doi.org/10.3390/ijms21228601.

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Sortase A (SrtA) is a membrane-associated enzyme that anchors surface-exposed proteins to the cell wall envelope of Gram-positive bacteria such as Staphylococcus aureus. As SrtA is essential for Gram-positive bacterial pathogenesis but dispensable for microbial growth or viability, SrtA is considered a favorable target for the enhancement of novel anti-infective drugs that aim to interfere with key bacterial virulence mechanisms, such as biofilm formation, without developing drug resistance. Here, we used virtual screening to search an in-house natural compound library and identified two natur

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Irma, Ade, Anja Meryandini, and Bedah Rupaedah. "Biofungicide Producing Bacteria: an In Vitro Inhibitor of Ganoderma boninense." HAYATI Journal of Biosciences 25, no. 4 (2018): 151. http://dx.doi.org/10.4308/hjb.25.4.151.

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Oil palm is widely known as one of vegetable oil sources and the main comodity in Indonesian agriculture because of the benefits in non-food and food industries. Ganoderma boninense attack results in considerable losses to agriculture. Chemical control creates a harmful effect on health and the environment. Biocontrol is required to take over the function of chemical control. This study aimed to select bacteria that produce bioactive compounds as biofungicide against G. boninense pathogenic fungi and identify bacteria producing biofungicide using molecular method. The stages of bacterial isola

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Bauer, Wolfgang D., and Max Teplitski. "Can plants manipulate bacterial quorum sensing?" Functional Plant Biology 28, no. 9 (2001): 913. http://dx.doi.org/10.1071/pp01064.

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This paper originates from an address at the 8th International Symposium on Nitrogen Fixation with Non-Legumes, Sydney, NSW, December 2000 Higher plants have been found to secrete a variety of unknown signal-mimic compounds that can stimulate or inhibit behaviors in bacteria, which are regulated by N-acyl homoserine lactone (AHL) signal molecules. A wide range of bacterial species use AHLs or other signal molecules to regulate the expression of many of their genes in response to changes in population density. Thus, the ability of higher plants to specifically alter AHL-regulated behavior in ba

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Al-Sa’doni, Haitham Husein, Fatima-Azzahra Delmani, Abdullah Mohammed Al Balushi, Ala’a Hamed Al-Ahmad, Sondos Omar Alsawakhneh, and Yaseen Ahmad Al-Soud. "Synthesis and antibacterial activity of some new 1,2,4-triazole derivatives bearing carbohydrazide moiety." European Journal of Chemistry 11, no. 2 (2020): 113–19. http://dx.doi.org/10.5155/eurjchem.11.2.113-119.1968.

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In this study, a series of 1,2,4-triazol-3-carbohydrazide derivatives and compound of 1,2,4-triazole-3-(4H)-thion have been synthesized. Structures and purity of the new compounds were confirmed by the use of their chromatographic and spectral data besides microanalysis. Four different bacterial stains for the study of the biological activity of compounds 6g, 7c, 7g and 7i; two Gram-positive strains, and two Gram-negative strains have been used. Compound 6g was found to be the most active of the four tested compounds against Pseudomonas aeruginosa, Bacillus cereus and Staphylococcus aureus, wi

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Ashu, Fred A., Jean Na-Iya, Brice E. N. Wamba, et al. "Antistaphylococcal Activity of Extracts, Fractions, and Compounds of Acacia polyacantha Wild (Fabaceae)." Evidence-Based Complementary and Alternative Medicine 2020 (March 16, 2020): 1–10. http://dx.doi.org/10.1155/2020/2654247.

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Acacia polyacantha is a medicinal plant traditionally used to treat livestock diseases and gastrointestinal infections; our study was undertaken to evaluate the antistaphylococcal activities of the methanolic leaf, bark, and root extracts, fractions, and compounds from Acacia polyacantha against a panel of 14 multidrug-resistant Staphylococcus bacterial strains overexpressing efflux pumps. The study was also extended to investigate two possible modes of action, that is, influence on bacterial growth kinetics and influence on proton-ATPase pumps, of the most active compound against a reference

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Jayasekera, Maithri M. K., Keysha Onheiber, John Keith, et al. "Identification of Novel Inhibitors of Bacterial Translation Elongation Factors." Antimicrobial Agents and Chemotherapy 49, no. 1 (2005): 131–36. http://dx.doi.org/10.1128/aac.49.1.131-136.2005.

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ABSTRACT Bacterial elongation factor Tu (EF-Tu) and EF-Ts are interacting proteins involved in polypeptide chain elongation in protein biosynthesis. A novel scintillation proximity assay for the detection of inhibitors of EF-Tu and EF-Ts, as well as the interaction between them, was developed and used in a high-throughput screen of a chemical library. Several compounds from a variety of chemical series with inhibitory properties were identified, including certain indole dipeptides, benzimidazole amidines, 2-arylbenzimidazoles, N-substituted imidazoles, and N-substituted guanidines. The in vitr

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Al-Joubory, Ahmood Kh Jebur, Rabiha Hameed Saleh, and Omar Abdulrahman Mohammed. "Synthesis and Characterization of some 2-Azetidinones Derived from 3-Nitro Phthalic Anhydride and Evaluation their Biological against Bacteria and Fungi." Materials Science Forum 1002 (July 2020): 360–68. http://dx.doi.org/10.4028/www.scientific.net/msf.1002.360.

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Reaction of the moiety 3-nitro phthalic anhydride with p- Phenylene diamine in (40 ml) acetic acid to give compound (p-amino phenyl)-3-nitro phthalimide (A1).Which that react with different aromatic aldehyde in ethanol absolute to give compounds hydrazone (A2-A5), then react this compounds (A2-A5) with chloro acetyl chloride in presence of TEA by using DMF as solvent to obtain 2-azetidinones (A6-A9).The compounds of all the newly synthesized structures were confirmed by and ,IR, 1H NMR as well as melting point. Some of these new structures showed antimicrobial activity (A7-A8) and anti-bacteri

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T. Abduljabbar, Tariq, and Mohammed K. Hadi. "Synthesis, Characterization and Antibacterial Evaluation of Some Coumarin Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 1 (2021): 249–57. http://dx.doi.org/10.31351/vol30iss1pp249-257.

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Coumarin derivatives have shown different biological activities, such as antifungal, antibacterial antiinflammatory, and antioxidant activities, besides antibiotic resistance modulating effects, and anti-HIV, hepatoprotective, and antitumor effect. So, new coumarin derivatives (hydrazones and an amide) were synthesized through multisteps reactions. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis. The compounds then evaluated for their anti-bacterial activity by means of well-diffusion method against two gram-positive bacteria (Staphylococcus aureus

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D. Noori, Sarmd, Mazin N. Mousa, and Shaker A. N. Al-Jadaan. "Synthesis of a New Conjugates of Imidazole wih Beta Lactam Moiety and Evaluation of its Expanded Antibacterial Activity." Oriental Journal of Chemistry 34, no. 5 (2018): 2495–501. http://dx.doi.org/10.13005/ojc/340535.

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Five compounds containing (2,4,5-triphenyl triphenyl-1H-) and azetidinone (beta-lactam) moiety were synthesized. The physical data and yield of synthesized compounds were recorded, the chemical structure of prepared compounds were characterized using FT-IR, 1H-NMR and elemental analysis. The antibacterial activity was evaluated using disc diffusion method that involve tow Gram positive (staph. aureus, E. Faecalis), two Gram negative (E. coli and ‎K. pneumoniae), and one anaerobic bacteria (streptococcus. Pyogen). Different concentration of the prepared compounds has been used, and the obtained

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Mariner, Katherine R., Rachel Trowbridge, Anil K. Agarwal, et al. "Furanyl-Rhodanines Are Unattractive Drug Candidates for Development as Inhibitors of Bacterial RNA Polymerase." Antimicrobial Agents and Chemotherapy 54, no. 10 (2010): 4506–9. http://dx.doi.org/10.1128/aac.00753-10.

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ABSTRACT Previous studies suggest that furanyl-rhodanines might specifically inhibit bacterial RNA polymerase (RNAP). We further explored three compounds from this class. Although they inhibited RNAP, each compound also inhibited malate dehydrogenase and chymotrypsin. Using biosensors responsive to inhibition of macromolecular synthesis and membrane damaging assays, we concluded that in bacteria, one compound inhibited DNA synthesis and another caused membrane damage. The third rhodanine lacked antibacterial activity. We consider furanyl-rhodanines to be unattractive RNAP inhibitor drug candid

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Ferrer-Vilanova, Amparo, Kristina Ivanova, María Díaz-González, et al. "Smart Sensing Fabrics for Live Bacteria Detection." Proceedings 2, no. 13 (2018): 916. http://dx.doi.org/10.3390/proceedings2130916.

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A smart textile for live bacteria detection of antimicrobial hospital tissues is here proposed. The capacity to detect viable bacteria is based on the use of Prussian Blue (PB) as electrochromic compound, with a clear reversible change of colour from PB to Prussian White (PW) after reduction from a bacterial metabolism process. PB nanoparticles are incorporated to polyester cotton fabrics by ultrasonic deposition. After performing different tests with bacterial samples of E. coli and S. aureus, a full colour change of the textiles was observed. These smart textiles will allow to determine the

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Turbant, Florian, David Partouche, Omar El Hamoui, et al. "Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq." Antibiotics 10, no. 3 (2021): 257. http://dx.doi.org/10.3390/antibiotics10030257.

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Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance for bacterial adaptation and survival in hosts. Small RNAs and Hfq are, for instance, involved in the response to antibiotics. Previous work has shown that the E. coli Hfq C-terminal region (Hfq-CTR) self-assembles into an amyloid structure. It was also demonstrated that the green tea compound EpiGallo Catechin Gallate (EGCG) binds to Hfq-CTR

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Pavlova, Julia A., Zimfira Z. Khairullina, Andrey G. Tereshchenkov, et al. "Triphenilphosphonium Analogs of Chloramphenicol as Dual-Acting Antimicrobial and Antiproliferating Agents." Antibiotics 10, no. 5 (2021): 489. http://dx.doi.org/10.3390/antibiotics10050489.

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In the current work, in continuation of our recent research, we synthesized and studied new chimeric compounds, including the ribosome-targeting antibiotic chloramphenicol (CHL) and the membrane-penetrating cation triphenylphosphonium (TPP), which are linked by alkyl groups of different lengths. Using various biochemical assays, we showed that these CAM-Cn-TPP compounds bind to the bacterial ribosome, inhibit protein synthesis in vitro and in vivo in a way similar to that of the parent CHL, and significantly reduce membrane potential. Similar to CAM-C4-TPP, the mode of action of CAM-C10-TPP an

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Ikpa, Chinyere Benardette Chinaka, Uchechukwu C. Okoro, Collins I. Ubochi, and Kieran O. Nwanorh. "Synthesis, Characterization and Antibacterial Activity of 2-Phenylsulphonamide Derivatives of Some Amino Acids." International Letters of Chemistry, Physics and Astronomy 70 (September 2016): 42–47. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.70.42.

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The 2-phenylsulphonamide derivatives of amino acids were synthesis by simple substitution of benzenesulphonylchloride (6) with amino acids (1-5) containing pharmacological active functionalities. Structures of the synthesised compounds (7a-7e) were characterised using FT-IR, NMR(1H,13C) and elemental analysis. The anti bacterial activities of the synthesised compounds were evaluated against gram positive bacteria: Staph and Streptococcus, gram negative bacteria: E-coli, Klebsiella, Proteus, and pseudomonas using 200 µl of 10 mg/ml and minimum inhibitory concentration (MIC) were also determined

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Tuo, Xinxin, Jie Yang, Yedong Zhang, and Peiyi Wang. "Synthesis of N-Methylmorpholinium Derivatives Possessing a 1,3,4-Oxadiazole Core as Feasible Antibacterial Agents against Plant Bacterial Diseases." Journal of Chemistry 2021 (September 1, 2021): 1–10. http://dx.doi.org/10.1155/2021/5415950.

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To develop a kind of quaternary ammonium compounds that can safely apply in agriculture for managing the plant bacterial diseases, herein, a series of N-methylmorpholinium derivatives possessing a classical 1,3,4-oxadiazole core were prepared and the antibacterial activities both in vitro and in vivo were screened. Bioassay results revealed that compounds 3l and 3i showed the strongest antibacterial activity toward pathogens Xanthomonas oryzae pv. oryzae and X. axonopodis pv. citri with the lowest EC50 values of 1.40 and 0.90 μg/mL, respectively. Phytotoxicity test trials indicated that target

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Boucherit, Hanane, Abdelouahab Chikhi, Abderrahmane Bensegueni, Amina Merzoug, and Jean-Michel Bolla. "The Research of New Inhibitors of Bacterial Methionine Aminopeptidase by Structure Based Virtual Screening Approach of ZINC DATABASE and In Vitro Validation." Current Computer-Aided Drug Design 16, no. 4 (2020): 389–401. http://dx.doi.org/10.2174/1573409915666190617165643.

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Background: The great emergence of multi-resistant bacterial strains and the low renewal of antibiotics molecules are leading human and veterinary medicine to certain therapeutic impasses. Therefore, there is an urgent need to find new therapeutic alternatives including new molecules in the current treatments of infectious diseases. Methionine aminopeptidase (MetAP) is a promising target for developing new antibiotics because it is essential for bacterial survival. Objective: To screen for potential MetAP inhibitors by in silico virtual screening of the ZINC database and evaluate the best pote

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Murniasih, Tutik, and Asep Bayu. "CARBON SOURCE OPTIMIZATION FOR ANTIBIOTIC PRODUCTION FROM AAPTOS-ASSOCIATED BACTERIA Rhodobacteracea bacterium SP.2.11." Marine Research in Indonesia 40, no. 2 (2016): 79–84. http://dx.doi.org/10.14203/mri.v40i2.63.

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Marine sponge Aaptos-aaptos is thought to produce antimicrobial aaptamine and its derivatives. To investigate whether its associated bacteria are in fact the producer of such bioactive compounds, a study of antibacterial compounds derived from Aaptos-associated bacteria was conducted. In this research, approximately 10 bacterial colonies were isolated from the sponge Aaptos aaptos. Among the bacteria isolated, the one that showed the most potential for producing antibacterial compounds was Rhodobacteracea bacterium. Extra and intracellular bacterial extract from this strain strongly inhibited

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Rahayu, Yuni Sri. "Isolation and Identification of Hydrocarbon Degradation Bacteria and Phosphate Solubilizing Bacteria in Oil Contaminated Soil in Bojonegoro, East Java, Indonesia." Indonesian Journal of Science and Technology 4, no. 1 (2019): 134. http://dx.doi.org/10.17509/ijost.v4i1.14923.

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Petroleum is a mixture of hydrocarbon complexes with organic compounds from sulfur, oxygen, nitrogen and metal-containing compounds. These organic compounds can be used as substrate for bacterial growth. This study aimed to isolate and identify hydrocarbon degrading bacteria and phosphate solubilizing bacteria in oil-contaminated soil in Bojonegoro. This study used an exploration method to find each of the two types of hydrocarbon degrading bacteria and phosphate solubilizing bacteria from soil samples in Bojonegoro that contaminated by oil. Identification of isolates bacterial included macros

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KUMAR, VIVEK, RAJNISH KUMAR, SALAHUDDIN, and AVIJIT MAZUMDER. "Design, Synthesis and in vitro Antibacterial Evaluation of Naphthalen-2-yloxy based Oxadiazole-2-thione Derivatives." Asian Journal of Chemistry 33, no. 2 (2021): 266–70. http://dx.doi.org/10.14233/ajchem.2021.22912.

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A series of novel Mannich bases 5-(naphthalen-2-yloxymethyl)-3-(substituted)aminomethyl-3H-[1,3,4]oxadiazole-2-thiones (5a-h) were synthesized by aminomethylation of substituted-1,3,4-oxadiazole-2(3H)-thione by equimolar concentration of primary or secondary amines. Synthesized compounds were characterized by spectrometric techniques (IR, 1H & 13C NMR), and evaluated for antibacterial potential against various Gram-positive and Gram-negative bacterial strains using cup-plate method employing ciprofloxacin as standard drug. Compounds 5a-c and 5g exhibited strong antibacterial activity again

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Kurniawati, Sri, Kikin Hamzah Mutaqin, and Giyanto . "EKSPLORASI DAN UJI SENYAWA BIOAKTIF BAKTERI AGENSIA HAYATI UNTUK PENGENDALIAN PENYAKIT KRESEK PADA PADI." JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA 15, no. 2 (2016): 170. http://dx.doi.org/10.23960/j.hptt.215170-179.

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Exploration of bacterial biocontrol agent and its potential bioactive compound to control rice bacterial leaf blight. The research aims were to obtain bacterial isolates which were potential as biological control agent of X. oryzae pv. oryzae, the causal agent of rice bacterial blight and to assess the effectiveness of their bioactive compounds, and to identify of the potential isolates. The research steps included bacterial isolation, screening based on antibiosis activity and pathogenicity test, characterization based on chitinolytic enzyme production, siderophores, and phosphate dissolution

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M.K., Kamalakkannan, Atthikumaran N., Aravind V., and Narandiran P.B. "A Comparative Study on Repairing of Binding Material Discontinuity Using Cultured Bacterial Compounds." International Journal of Psychosocial Rehabilitation 23, no. 4 (2019): 1117–21. http://dx.doi.org/10.37200/ijpr/v23i4/pr190438.

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Mambe, Flora T., Jean Na-Iya, Ghislain W. Fotso, et al. "Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds from Acacia polyacantha Willd. against MDR Gram-Negative Bacteria." Evidence-Based Complementary and Alternative Medicine 2019 (March 7, 2019): 1–13. http://dx.doi.org/10.1155/2019/7507549.

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The present study aimed to assess the in vitro antibacterial and antibiotic modifying activities of methanol extracts prepared from the leaf (APL) and bark (APB) of Acacia polyacantha, fractions (APLa-d) and compounds isolated from APL against a panel of multidrug resistant (MDR) Gram-negative bacteria. Leaf extract was subjected to column chromatography for compounds isolation; antibacterial assays were performed on samples alone and with an efflux pump inhibitor (EPI), respectively, and several antibiotics on the tested bacteria. The phytochemical investigation of APL led to the isolation of

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Topka-Bielecka, Gracja, Aleksandra Dydecka, Agnieszka Necel, et al. "Bacteriophage-Derived Depolymerases against Bacterial Biofilm." Antibiotics 10, no. 2 (2021): 175. http://dx.doi.org/10.3390/antibiotics10020175.

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In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, a

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Murniasih, Tutik, Masteria Yunovilsa Putra, and Tri Aryono Hadi. "THE ANTIBACTERIAL EVALUATION OF HALICLONA ASSOCIATED BACTERIA AND THE RELATING COMPOUNDS DERIVED FROM THE HOST." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (2018): 412. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25510.

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Objective: The objective of this study was to investigate the active compounds derived from Haliclona sp. associated bacteria collected from Untung Jawa Island, Jakarta.Methods: The bacterial isolation, screening of antibacterial activity, purification, and prediction of potential compounds using liquid chromatography– mass spectroscopy/mass spectroscopy (LC–MS/MS) as well as 16S rDNA bacterial characterization were conducted.Results: The potential extract of bacterial strain UJ.17.10-4 showed the highest anti-Gram-positive bacteria. The 16S rDNA gene of this strain had 99% similarity with the

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