Relevant bibliographies by topics / Bacterial efflux pumps

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Academic literature on the topic 'Bacterial efflux pumps'

Author: Grafiati
Published: 24 April 2022

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Journal articles on the topic "Bacterial efflux pumps"

1

Huang, Lulu, Cuirong Wu, Haijiao Gao, et al. "Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview." Antibiotics 11, no. 4 (2022): 520. http://dx.doi.org/10.3390/antibiotics11040520.

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Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial cell membrane and periplasm and remove diverse extraneous substrates, including antimicrobials, organic solvents, toxic heavy metals, etc., from bacterial cells. This review systematically and comprehensively summarizes the functions of multiple efflux pumps families and discusses their potential applications. The biological functions of efflux
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2

Pasqua, Grossi, Zennaro, et al. "The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells." Microorganisms 7, no. 9 (2019): 285. http://dx.doi.org/10.3390/microorganisms7090285.

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Efflux pumps represent an important and large group of transporter proteins found in all organisms. The importance of efflux pumps resides in their ability to extrude a wide range of antibiotics, resulting in the emergence of multidrug resistance in many bacteria. Besides antibiotics, multidrug efflux pumps can also extrude a large variety of compounds: Bacterial metabolites, plant-produced compounds, quorum-sensing molecules, and virulence factors. This versatility makes efflux pumps relevant players in interactions not only with other bacteria, but also with plant or animal cells. The multid
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3

Stubenrauch, Christopher J., Rebecca S. Bamert, Jiawei Wang, and Trevor Lithgow. "A noncanonical chaperone interacts with drug efflux pumps during their assembly into bacterial outer membranes." PLOS Biology 20, no. 1 (2022): e3001523. http://dx.doi.org/10.1371/journal.pbio.3001523.

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Bacteria have membrane-spanning efflux pumps to secrete toxic compounds ranging from heavy metal ions to organic chemicals, including antibiotic drugs. The overall architecture of these efflux pumps is highly conserved: with an inner membrane energy-transducing subunit coupled via an adaptor protein to an outer membrane conduit subunit that enables toxic compounds to be expelled into the environment. Here, we map the distribution of efflux pumps across bacterial lineages to show these proteins are more widespread than previously recognised. Complex phylogenetics support the concept that gene c
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4

Kvist, Malin, Viktoria Hancock, and Per Klemm. "Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation." Applied and Environmental Microbiology 74, no. 23 (2008): 7376–82. http://dx.doi.org/10.1128/aem.01310-08.

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ABSTRACT Bacterial biofilms cause numerous problems in health care and industry; notably, biofilms are associated with a large number of infections. Biofilm-dwelling bacteria are particularly resistant to antibiotics, making it hard to eradicate biofilm-associated infections. Bacteria rely on efflux pumps to get rid of toxic substances. We discovered that efflux pumps are highly active in bacterial biofilms, thus making efflux pumps attractive targets for antibiofilm measures. A number of efflux pump inhibitors (EPIs) are known. EPIs were shown to reduce biofilm formation, and in combination t
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5

Marquez, Béatrice. "Bacterial efflux systems and efflux pumps inhibitors." Biochimie 87, no. 12 (2005): 1137–47. http://dx.doi.org/10.1016/j.biochi.2005.04.012.

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6

Ebbensgaard, Anna Elisabeth, Anders Løbner-Olesen, and Jakob Frimodt-Møller. "The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance." Antibiotics 9, no. 12 (2020): 855. http://dx.doi.org/10.3390/antibiotics9120855.

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Antibiotic resistance is on the rise and has become one of the biggest public health challenges of our time. Bacteria are able to adapt to the selective pressure exerted by antibiotics in numerous ways, including the (over)expression of efflux pumps, which represents an ancient bacterial defense mechanism. Several studies show that overexpression of efflux pumps rarely provides clinical resistance but contributes to a low-level resistance, which allows the bacteria to persist at the infection site. Furthermore, recent studies show that efflux pumps, apart from pumping out toxic substances, are
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7

Zwama, Martijn, and Kunihiko Nishino. "Ever-Adapting RND Efflux Pumps in Gram-Negative Multidrug-Resistant Pathogens: A Race against Time." Antibiotics 10, no. 7 (2021): 774. http://dx.doi.org/10.3390/antibiotics10070774.

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The rise in multidrug resistance (MDR) is one of the greatest threats to human health worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial infections are becoming untreatable by commercially available antibiotics. One of the main causes of MDR is the over-expression of intrinsic and acquired multidrug efflux pumps, belonging to the resistance-nodulation-division (RND) superfamily, which can efflux a wide range of structurally different antibiotics. Besides over-expression, however, recent amino acid substitutions within the pumps themselves—causing an increase
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8

Kumar, Sanath, Mun Mun Mukherjee, and Manuel F. Varela. "Modulation of Bacterial Multidrug Resistance Efflux Pumps of the Major Facilitator Superfamily." International Journal of Bacteriology 2013 (December 5, 2013): 1–15. http://dx.doi.org/10.1155/2013/204141.

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Bacterial infections pose a serious public health concern, especially when an infectious disease has a multidrug resistant causative agent. Such multidrug resistant bacteria can compromise the clinical utility of major chemotherapeutic antimicrobial agents. Drug and multidrug resistant bacteria harbor several distinct molecular mechanisms for resistance. Bacterial antimicrobial agent efflux pumps represent a major mechanism of clinical resistance. The major facilitator superfamily (MFS) is one of the largest groups of solute transporters to date and includes a significant number of bacterial d
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9

Durães, Fernando, Madalena Pinto, and Emília Sousa. "Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators." Current Medicinal Chemistry 25, no. 42 (2019): 6030–69. http://dx.doi.org/10.2174/0929867325666180209142612.

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Antibiotic resistance is one of the most pressing health issues of our days. It can arise due to a multiplicity of factors, such as target modification, decrease in the drug uptake, changes in the metabolic pathways and activation of efflux pumps. The overexpression of efflux pumps is responsible for the extrusion of drugs, making antibiotic therapy fail, as the quantity of intracellular antibiotic is not enough to provide the desired therapeutic effect. Efflux pumps can be included in five families according to their composition, nature of substrates, energy source, and number of transmembran
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10

Martins, Marta, Matthew P. McCusker, Miguel Viveiros, et al. "A Simple Method for Assessment of MDR Bacteria for Over-Expressed Efflux Pumps." Open Microbiology Journal 7, no. 1 (2013): 72–82. http://dx.doi.org/10.2174/1874285801307010072.

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It is known that bacteria showing a multi-drug resistance phenotype use several mechanisms to overcome the action of antibiotics. As a result, this phenotype can be a result of several mechanisms or a combination of thereof. The main mechanisms of antibiotic resistance are: mutations in target genes (such as DNA gyrase and topoisomerase IV); over-expression of efflux pumps; changes in the cell envelope; down regulation of membrane porins, and modified lipopolysaccharide component of the outer cell membrane (in the case of Gram-negative bacteria). In addition, adaptation to the environment, suc
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