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Dissertations / Theses on the topic 'Bacterial glycosylation'

Author: Grafiati

Published: 11 September 2021

Last updated: 30 July 2025

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1

Larkin, Angelyn (Angelyn Kathryne). "Investigation of asparagine-linked glycosylation in archaeal and bacterial systems." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62725.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, February 2011.<br>Vita. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Asparagine-linked protein glycosylation entails the stepwise assembly of an oligosaccharide onto a polyisoprenyl diphosphate carrier, followed by the en bloc transfer of the glycan onto acceptor proteins by oligosaccharyl transferase (OTase). It is now clear that this N-linked protein modification catalyzed by OTases is conserved in all three kingdoms of life. In contrast to eukaryotic OTases, which are multimeric c

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2

Lukose, Vinita. "Priming and processing glycosyltransferases in bacterial N-linked glycosylation pathways." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101550.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Bacterial cell surfaces prominently feature a variety of complex glycoconjugates. Although these structures are very diverse, the biosynthesis of these glycoconjugates shares common themes. In particular, a priming glycosyltransferase or phosphoglycosyltransferase (PGT) initiates the biosynthesis of glycans by transferring a Cl'-phosphosugar onto a polyprenol phosphate substrate. The membrane-bound polyprenol diphosphosugar pr

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3

Bhullar, Kirandeep. "Mucus-bacteria interactions in the gut : investigating the role of the mucin Muc2 and its glycosylation in host defense during enteric bacterial infections." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57682.

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The intestinal mucus layer, which is largely composed of the secreted mucin Muc2 provides a first line of defense in the intestine. Muc2 is a heavily O-glycosylated protein with core 1 and core 3 derived O-glycans as primary constituents. It plays an important role in host defense against the attaching/effacing (A/E) pathogen Citrobacter rodentium. However whether it provides protection against the invasive human pathogen Salmonella is still unclear. Furthermore, the role of O-glycosylation in mediating the protective role played by the Muc2 mucin against enteric pathogens has not been investi

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4

Fletcher, Madison Hill. "Synthesis of Non-Natural Cyclic Di-Nucleotides for the Investigation of Bacterial Signaling Pathways." Diss., Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/429284.

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Chemistry<br>Ph.D.<br>Humans navigate the world and interact with others through a complex series of communicative tools. We experience both internal and external stimuli, such as pangs of hunger or pain from an injury, and both verbal and nonverbal language. Bacteria also possess the ability to communicate, albeit in more discreet, yet no less complex ways. Bacteria rely on an incredibly diverse signaling system of triggers and responses in order to survive and to thrive. While we perceive language with our eyes and ears, bacteria employ a system of small molecules to relay both intra- and ex

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5

Weaver, Danielle. "N-linked glycosylation in Campylobacter jejuni and Campylobacter fetus and N-linked glycans as targets for antibody-based detection." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/nlinked-glycosylation-in-campylobacter-jejuni-and-campylobacter-fetus-and-nlinked-glycans-as-targets-for-antibodybased-detection(2b739b0d-84a3-47cc-af7a-d915b4caf37c).html.

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Campylobacter spp., especially C. jejuni and C. coli, are the leading cause of bacterial gastroenteritis in Europe. There is a recognised need to develop detection tools which can be performed on farms to facilitate reducing the presence of Campylobacter in poultry. A similar application could be beneficial for detection of C. fetus, a veterinary pathogen which causes significant economic loss in the cattle industry. Campylobacter species perform protein N-linked glycosylation and in C. jejuni at least 150 proteins, many of which are surface-exposed, may be modified. Therefore, the first porti

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6

Bascans, Élodie. "Des voies durables et respectueuses de l'environnement pour la génération de nouveaux assemblages de biopolymères et la glycosylation de composés marins - selon une approche de biomimétisme." Electronic Thesis or Diss., Pau, 2023. http://www.theses.fr/2023PAUU3035.

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Pour faire face aux impacts de la chimie conventionnelle et des produits pétrosourcés sur la santé humaine et les écosystèmes, la chimie verte et les macromolécules d'origine biologique sont une source infinie d'innovation. Ce projet s'inscrit dans une approche de bioinspiration et repose sur l'utilisation d'enzymes bactériennes dans l'objectif d'évaluer leur potentiel pour : (1) la glucosylation de molécules marines pour la création de filtres solaires, et (2) l'assemblage de polysaccharides marins et bactériens réticulés par des protéines « sur mesure ». Dans le premier cas, il s'agit de pro

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7

Molero, Andrades Raquel Ángeles. "Implicación de la glicosilación en el ensamblaje del flagelo y las fimbrias de Aeromonas hydrophila AH-1." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/146253.

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El género Aeromonas está constituido por bacilos gram negativos y comprende patógenos de animales poiquilotermos y oportunistas en humanos. La virulencia de Aeromonas hydrophila AH-1 es multifactorial, siendo el lipopolisacárido (LPS), el flagelo (polar y lateral) y la lámina S importantes factores de patogenicidad. La mutación del gen wbpL, implicado en la biosíntesis del antígeno O del LPS, da lugar a la pérdida de antígeno O, una bajada en el peso molecular de las flagelinas polares y la aparición de fimbrias en la superficie bacteriana. Se procedió a estudiar si las flagelinas polares y la

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8

Fer, Mickaël. "Fonctionnalisation d'un squelette aminoribosyluridine : vers de nouveaux inhibiteurs et des outils moléculaires pour la caractérisation de la transférase bactérienne MraY." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P631/document.

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Le phénomène de résistance aux antibiotiques est un grave problème de santé publique. Afin de lutter contre l’émergence continue de résistances, le développement de nouveaux agents antibactériens s’avère nécessaire. La translocase bactérienne MraY, enzyme transmembranaire impliquée dans la biosynthèse du peptidoglycane, est essentielle à la survie de la bactérie. Sans équivalent chez les eucaryotes, elle n’est actuellement la cible d’aucun médicament et constitue donc une cible de choix pour le développement de nouveaux antibiotiques. Des molécules naturelles de structure complexe telles que l

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9

Olsson, Johan. "Synthesis of bacterial oligosaccharides from N. meningitidis and mechanistic details of stereoselective glycosylations using a novel bicyclic donor /." Stockholm : Department of organic chemistry, Stockholm university, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29568.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2009.<br>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 1: Manuscript. Paper 5: Manuscript. Härtill 5 uppsatser.

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10

Cowcher, David Paul. "The development of enhanced Raman scattering for the trace analysis of biomolecules." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-development-of-enhanced-raman-scattering-for-the-trace-analysis-of-biomolecules(0cf1158e-ff5f-4841-a679-16cde8ba0d94).html.

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Raman spectroscopy is an established analytical technique for determining molecular structure, whose major drawback is lack of sensitivity. Enhanced Raman scattering techniques, such as surface-enhanced Raman scattering (SERS) and tip-enhanced Raman scattering (TERS), utilise nanoscale substrates to enhance the Raman signal through the interaction of surface charges with the incident electromagnetic radiation. Here, nanoparticle-based SERS was used to detect dipicolinic acid (DPA), a biomarker for bacterial spores. Whilst this has been demonstrated previously, the use of a different nanopartic

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11

Speciale, Immacolata. "Structural insight into new glycosylation patterns of microbial (bacterial and viral) origin." Tesi di dottorato, 2017. http://www.fedoa.unina.it/11744/1/Speciale_Immacolata_29.pdf.

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Sugars can be divided into two major subfamilies: the simple sugars (monosaccharides) and the complex sugars (oligosaccharides or polysaccharides depending on the unit of the monosaccharides). Complexity in structure arises from the elevated number of isomers that even two simple monosaccharides can generate, for instance, two glucose units can combine into 11 different disaccharides, while two identical aminoacids form only one dipeptide. Carbohydrates, simple or complex, can be further linked to other molecules, as proteins and fats to form glycoproteins and glycolipids (known as glycoconju

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12

Milner, S. J., C. Carrick, Kevin G. Kerr, et al. "Probing bacterial uptake of glycosylated ciprofloxacin conjugates." 2014. http://hdl.handle.net/10454/10511.

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No<br>Mono- and disaccharide-functionalised conjugates of the fluoroquinolone antibiotic ciprofloxacin have been synthesised and used as chemical probes of the bacterial uptake of glycosylated ciprofloxacin. Their antimicrobial activities against a panel of clinically relevant bacteria were determined: the ability of these conjugates to inhibit their target DNA gyrase and to be transported into the bacteria was assessed by using in vivo and in vitro assays. The data suggest a lack of active uptake through sugar transporters and that although the addition of monosaccharides is compatible with t

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13

"Protein Post Translational Modifications in Human Diseases: Bacterial Glycosylation Profiling by Peptide Microarray / Protein Phosphorylation Analysis in High Risk Neuroblastoma." Doctoral diss., 2014. http://hdl.handle.net/2286/R.I.25885.

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abstract: ABSTRACT Post Translational Modifications (PTMs) are a series of chemical modifications with the capacity to expand the structural and functional repertoire of proteins. PTMs can regulate protein-protein interaction, localization, protein turn-over, the active state of the protein, and much more. This can dramatically affect cell processes as relevant as gene expression, cell-cell recognition, and cell signaling. Along these lines, this Ph.D. thesis examines the role of two of the most important PTMs: glycosylation and phosphorylation. In chapters 2, 3 and 4, a 10,000 peptid

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14

Schirm, Michael. "Proteomic approaches for the detection of unusual post-translational modifications in simple and complex bacterial protein mixtures." Thèse, 2004. http://hdl.handle.net/1866/16749.

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15

Kus, Julianne. "Diversity of Pseudomonas aeruginosa Type IV Pilins and Identification of a Novel D-arabinofuranose Post-translational Modification." Thesis, 2008. http://hdl.handle.net/1807/11222.

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The opportunistic bacterial pathogen Pseudomonas aeruginosa uses type IV pili (T4P) for adherence to, and rapid colonization of, surfaces via twitching motility. T4P are formed from thousands of pilin (PilA) subunits. Two groups of P. aeruginosa pilins were described previously (I and II), distinguished by protein length and sequence. PilA_I was glycosylated with an O-antigen subunit through the action of PilO/TfpO, encoded downstream of pilA_I. To determine if additional pilin variants existed, analysis of the pilin locus of >300 P. aeruginosa strains from a variety of environments was co

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16

Moreira, Patrícia Maria Iria. "Os microorganismos orais e o oraloma da diabetes tipo 2." Master's thesis, 2013. http://hdl.handle.net/10400.14/13791.

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Os estudos experimentais no âmbito da proteómica de tecidos orais fornecem-nos dados que permitem compreender os mecanismos moleculares, os perfis de expressão proteica, a sua regulação, a presença de modificações pós-tradução e as vias de sinalização modificadas na Diabetes Melitos tipo 2. O presente trabalho tem como objetivo verificar a relação das proteínas microbianas existentes na cavidade oral de pacientes com Diabetes Melitos tipo 2 com o estado de glicosilação das proteínas salivares humanas e a sua relação com a etiologia desta doença e das suas complicações. A catalogação da

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17

Girard, Victoria. "Étude et inhibition de l'adhésine impliquée dans l'adhérence diffuse (AIDA-I) d'escherichia coli." Thèse, 2008. http://hdl.handle.net/1866/6397.

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18

SCHIFANO, EMILY. "The host-pathogen interactions in the Caenorhabditis elegans animal model: the role of glycosylation and a tool to screen for probiotic bacteria." Doctoral thesis, 2020. http://hdl.handle.net/11573/1372501.

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In this project, the role of the pmr-1 gene in the glycosylation process and in the host-microrganism interaction was analyzed in C. elegans model system. Glycosylation produces a large number of glycans, polysaccharides whose different morphology reflects the multiplicity of biological processes in which they are involved. The emerging role of glycans in the innate and acquired immunity of vertebrates makes them a target for the study of the molecular mechanisms underlying the host-pathogen interaction, in order to develop new therapeutic approaches. The Ca2+-ATPase, encoded by the pmr-1 gene

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