Relevant bibliographies by topics / Bacterial meningitis

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Bacterial meningitis'

Author: Grafiati
Published: 4 June 2021
Last updated: 30 May 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Bacterial meningitis.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Bacterial meningitis"

1

Amin, Muhammad, Asim Khurshid, Mukhtar Ahmad, and Zunaira Javed. "Etiology and outcome of culture proven bacterial meningitis in children 6 to 24 months of age." Professional Medical Journal 26, no. 09 (September 10, 2019): 1451–56. http://dx.doi.org/10.29309/tpmj/2019.26.09.2562.

Full text
Abstract:
Introduction: Pediatric bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and leaves some survivors with significant sequelae. More than 2/3 cases of meningitis occur in the 1st 2 years of life, owing to decreased immunity and high vascularity of the brain.This study was conducted to determine the frequency of hemophilus influenzae type b, streptococcus pneumonia and neisseria meningitidis and outcome in culture proven meningitis in children 6 months to 24 months. Study Design: Case series. Setting: Paeds Unit 1, Bahawal Victoria Hospital, Bahawalpur and Paeds Unit of District Headquarter (DHQ) Teaching Hospital, Dera Ghazi Khan. Period: 1st April 2017 to 30th September 2018. Material and Methods: A total of 220 children (110 from each center) of either sex with culture proven meningitis, aged 6 months to 24 months, were included in the study. Demographics, duration of fever, history of seizures, weight of child, vaccination status and bacteria isolated from CSF and outcome were analyzed. The outcome in the form of mortality was noted during the first 10 days of hospital stay. Results: Amongst a total of 220 children, 123 (55.9%) were male. There were 130 (59.1%) children who were less than or equal to 1 year of age. There were 154 (70.0%) children who were having a weight of 7 to 10 kg. Vaccination status was, 111 (50.5%) were fully vaccinated, 59 (26.8%) partially vaccinated and 50 (22.7%) not vaccinated. Duration of fever was, 141 (64.1%) had fever for more than 5 days. There were 139 (63.2%) children who had a history of seizures. Streptococcus pneumonia was the commonest bacteria found in 110 (50%) children followed by neisseria meningitides 53 (24.1%), H. Influenza 37 (16.8%). Overall mortality was noted in 34 (15.5%) children. Conclusion: In children with bacterial meningitis, mortality was high and most common bacteria were found to be s.pneumoniae followed by neisseria meningitidis and h.influenzae. Awareness about the empiric and directed antimicrobial therapy will help to lower the burden of morbidity and mortality related to bacterial meningitis.
APA, Harvard, Vancouver, ISO, and other styles
2

Alnomasy, Sultan F., Bader S. Alotaibi, Ahmed H. Mujamammi, Elham A. Hassan, and Mohamed E. Ali. "Microbial aspects and potential markers for differentiation between bacterial and viral meningitis among adult patients." PLOS ONE 16, no. 6 (June 11, 2021): e0251518. http://dx.doi.org/10.1371/journal.pone.0251518.

Full text
Abstract:
Objectives Meningitis is a medical emergency with permanent disabilities and high mortality worldwide. We aimed to determine causative microorganisms and potential markers for differentiation between bacterial and viral meningitis. Methodology Adult patients with acute meningitis were subjected to lumber puncture. Cerebrospinal fluid (CSF) microorganisms were identified using Real-time PCR. PCT and CRP levels, peripheral and CSF-leucocyte count, CSF-protein and CSF-glucose levels were assessed. Results Out of 80 patients, infectious meningitis was confirmed in 75 cases; 38 cases were bacterial meningitis, 34 cases were viral meningitis and three cases were mixed infection. Higher PCT, peripheral and CSF-leukocytosis, higher CSF-protein and lower CSF-glucose levels were more significant in bacterial than viral meningitis patients. Neisseria meningitides was the most frequent bacteria and varicella-zoster virus was the most common virus. Using ROC analyses, serum PCT and CSF-parameters can discriminate bacterial from viral meningitis. Combined ROC analyses of PCT and CSF-protein significantly improved the effectiveness in predicting bacterial meningitis (AUC of 0.998, 100%sensitivity and 97.1%specificity) than each parameter alone (AUC of 0.951 for PCT and 0.996 for CSF-protein). Conclusion CSF-protein and serum PCT are considered as potential markers for differentiating bacterial from viral meningitis and their combination improved their predictive accuracy to bacterial meningitis.
APA, Harvard, Vancouver, ISO, and other styles
3

Leu, Sheng, Neary Pirrone, and Wen Mueller. "Acute Bacterial Meningitis: A Systemic Review of Diagnosis and Treatment." Neuroscience and Neurological Surgery 1, no. 4 (December 15, 2017): 01–02. http://dx.doi.org/10.31579/2578-8868/024.

Full text
Abstract:
Bacterial meningitis is a medical emergency requiring immediate diagnosis and immediate treatment. Streptococcus pneumoniae and Neisseria meningitidis are the most common and most aggressive pathogens of meningitis. Emerging antibiotic resistance is an upcoming challenge. Clinical and experimental studies have established a more detailed understanding of the mechanisms resulting in brain damage, sequelae and neuropsychological deficits. We summarize the current pathophysiological concept of acute bacterial meningitis and present current treatment strategies.
APA, Harvard, Vancouver, ISO, and other styles
4

Liu, Lu, Jixuan Li, Dong Huo, Zhong Peng, Ruicheng Yang, Jiyang Fu, Bojie Xu, Bo Yang, Huanchun Chen, and Xiangru Wang. "Meningitic Escherichia coli Induction of ANGPTL4 in Brain Microvascular Endothelial Cells Contributes to Blood–Brain Barrier Disruption via ARHGAP5/RhoA/MYL5 Signaling Cascade." Pathogens 8, no. 4 (November 22, 2019): 254. http://dx.doi.org/10.3390/pathogens8040254.

Full text
Abstract:
Bacterial meningitis is currently recognized as one of the most important life-threatening infections of the central nervous system (CNS) with high morbidity and mortality, despite the advancements in antimicrobial treatment. The disruption of blood–brain barrier (BBB) induced by meningitis bacteria is crucial for the development of bacterial meningitis. However, the complete mechanisms involving in the BBB disruption remain to be elucidated. Here, we found meningitic Escherichia coli induction of angiopoietin-like 4 (ANGPTL4) in brain microvascular endothelial cells (BMECs) contributes to BBB disruption via ARHGAP5/RhoA/MYL5 signaling cascade, by the demonstration that ANGPTL4 was significantly upregulated in meningitis E. coli infection of BMECs as well as mice, and treatment of the recombinant ANGPTL4 protein led to an increased permeability of the BBB in vitro and in vivo. Moreover, we found that ANGPTL4 did not affect the expression of tight junction proteins involved in BBB disruption, but it increased the expression of MYL5, which was found to have a negative role on the regulation of barrier function during meningitic E. coli infection, through the activation of RhoA signaling pathway. To our knowledge, this is the first report demonstrating the disruption of BBB induced by ANGPTL4 through the ARHGAP5/RhoA/MYL5 pathway, which largely supports the involvement of ANGPTL4 during meningitic E. coli invasion and further expands the theoretical basis for the mechanism of bacterial meningitis.
APA, Harvard, Vancouver, ISO, and other styles
5

Diawara, Idrissa, Khalid Katfy, Khalid Zerouali, Houria Belabbes, and Naima Elmdaghri. "A duplex real-time PCR for the detection of Streptococcus pneumoniae and Neisseria meningitidis in cerebrospinal fluid." Journal of Infection in Developing Countries 10, no. 01 (January 31, 2016): 53–61. http://dx.doi.org/10.3855/jidc.5647.

Full text
Abstract:
Introduction: Acute bacterial meningitis is one of the most severe infectious diseases. Rapid, accurate, and inexpensive diagnosis of bacterial meningitis is crucial for patient management. This study describes a duplex real-time (RT) PCR assay for detection of Neisseria meningitidis and Streptococcus pneumoniae in the cerebrospinal fluid (CSF) for meningitis diagnosis using SYBR Green-based RT-PCR method coupled with melting curve analysis. Methodology: We used SYBR Green-based RT-PCR method coupled with melting curve analysis to detect S. pneumoniae and N. meningitidis in CSF samples. The sensitivity, specificity, and limit of detection were determined. The gold standard for routine tests of CSF analysis is direct examination, culture, and/or latex agglutination. The assay was evaluated on 132 CSF samples to measure clinical sensitivity. Results: A duplex RT-PCR assay for N. meningitidis and S. pneumoniae detection in CSF was evaluated. Two peaks at different melting temperatures (87.5°C and 85.5°C) for N. meningitidis and S. pneumoniae, respectively, were obtained. The sensitivity of RT-PCR was 100% (95% confidence limits [CI] = 82.4–100) for N. meningitidis and 100% (95% CI = 85.1–100) for S. pneumoniae. Specificity was the same (100%) for the bacteria (95% CI = 88.6–100). The percentage of cases accurately diagnosed with meningitis caused by N. meningitidis and S. pneumoniae increased to 50.7% and 28.6%, respectively, when RT-PCR was added to the standard microbiologic methods. Conclusions: Duplex RT-PCR and melting curve analysis with SYBR Green is an inexpensive, sensitive, and specific method to rapidly diagnose bacterial meningitis. Accurate identification of the bacterial causative agents will improve patient management and epidemiological investigations.
APA, Harvard, Vancouver, ISO, and other styles
6

Claudia, Cambrea Simona, Marcas Consuela, Diaconu Simona, Mihai Raluca, Pinzaru Anca Daniela, Mangu Florin, and Mihai Larisia. "Evolution of Different Bacterial Mningoencephalitis: Series of Case Presentations and Literature Review." ARS Medica Tomitana 25, no. 3 (August 1, 2019): 142–48. http://dx.doi.org/10.2478/arsm-2019-0029.

Full text
Abstract:
Abstract Bacterial meningitis is one of the most important medical emergencies, a life-threatening condition that leads to death in all the cases in untreated patients. In infants and young children, especially under 5 years old, the most encountered and severe forms are caused by Streptococcus pneumoniae, Neisseria meningitidis and Hemophilus influenzae type b. The risk of neurological impairment after an acute episode of bacterial meningitis is relatively high. Worldwide, prevention through vaccination decreased dramatically incidence and mortality related to these disease. In Romania vaccination for Neisseria meningitides is optional available for just 6 months, vaccination for Streptococcus pneumoniae by one year, and for Haemophylus influenzae type B is available over 10 years. We present evolution of a series of three cases with different bacterial meningoencephalitis with severe evolution and prolonged hospitalization. All these cases were reported in unvaccinated children for germs that cause meningitis.
APA, Harvard, Vancouver, ISO, and other styles
7

Sharma, Supriya, Jyoti Acharya, Dominique A. Caugant, Megha Raj Banjara, Prakash Ghimire, and Anjana Singh. "Detection of Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae in Culture Negative Cerebrospinal Fluid Samples from Meningitis Patients Using a Multiplex Polymerase Chain Reaction in Nepal." Infectious Disease Reports 13, no. 1 (March 1, 2021): 173–80. http://dx.doi.org/10.3390/idr13010019.

Full text
Abstract:
The rapid identification of bacteria causing meningitis is crucial as delays in the treatment increase mortality rate. Though considered as the gold standard for the laboratory diagnosis of bacterial meningitis, culture might give false negative results in a case of patients under antibiotics prior to lumbar puncture. This study aimed to detect Streptococcus pneumoniae, Neisseria meningitidis and Haemophilus influenzae by a multiplex polymerase chain reaction (PCR) in culture-negative cerebrospinal fluid samples collected from clinically suspected meningitis cases attending different hospitals in Kathmandu, Nepal from January 2017 to December 2019. S. pneumoniae, N. meningitidis and H. influenzae were detected in 8.59% (33/384) of the specimens by PCR and 7.55% (29/384) of the specimens by culture. Correlation between culture and PCR of the same sample was good (Spearman’s rho correlation coefficient = 0.932). However, the difference in positivity between culture and PCR was statistically not significant (p value > 0.05). In four specimens, culture could not detect any of the targeted bacteria whereas PCR could detect presence of H. influenzae. PCR increases the diagnostic yield for bacterial meningitis. PCR may be considered as an adjunctive test for establishing the cause of infection in culture negative clinically suspected meningitis cases.
APA, Harvard, Vancouver, ISO, and other styles
8

Elistratova, T. A., E. P. Tikhonova, I. N. Protasova, and V. S. Emelyashin. "Pneumococcal Meningitis in Adults: Clinical-Epidemiological and Diagnostic Aspects." Epidemiology and Vaccine Prevention 17, no. 3 (June 20, 2018): 63–67. http://dx.doi.org/10.31631/2073-3046-2018-17-3-63-67.

Full text
Abstract:
Relevance. Foreign and domestic authors notice that over the past thirty years there has been a significant reduction in the incidence of meningococcal infection, in contrast to bacterial meningitis not meningococcal etiology. S. pneumoniae occupies one of the leading places in the etiological structure of bacterial meningitis in the Russian Federation The purpose is of substantiation of the complex approach to the diagnosis of pneumococcal meningitis in adults, taking into account the clinical and epidemiological features of the disease and highly sensitive laboratory tests Materials and methods. Was conducted a retrospective analysis of 38 case histories of patients who were hospitalized at the Krasnoyarsk Interdistrict Clinical Emergency Hospital named after NS Karpovich with bacterial meningitis during 2015 to 2017. Results. Among those hospitalized with the diagnosis of «bacterial meningitis» the leading role in the etiology of the disease belonged to Streptococcus pneumoniae (55.2%), in other cases: Staphylococcus aureus, Streptococcus spp, fungi of the genus Candida spp., E. coli, Neisseria meningitidis, Cryptococcus spp., Some bacteria were detected in associations with other bacterial species or viruses, in 7.8% cases the pathogen was not detected. Conclusion. Microbiological diagnosis of bacterial meningitis requires the use of a set of methods that include not only microscopic, bacteriological and serological (latex agglutination) studies, but also PCR detection of pathogenic microorganisms in the cerebrospinal fluid, who diagnostic value is 46.4%.
APA, Harvard, Vancouver, ISO, and other styles
9

Janowski, Andrew B., and Jason G. Newland. "From the microbiome to the central nervous system, an update on the epidemiology and pathogenesis of bacterial meningitis in childhood." F1000Research 6 (January 27, 2017): 86. http://dx.doi.org/10.12688/f1000research.8533.1.

Full text
Abstract:
In the past century, advances in antibiotics and vaccination have dramatically altered the incidence and clinical outcomes of bacterial meningitis. We review the shifting epidemiology of meningitis in children, including after the implementation of vaccines that target common meningitic pathogens and the introduction of intrapartum antibiotic prophylaxis offered to mothers colonized withStreptococcus agalactiae. We also discuss what is currently known about the pathogenesis of meningitis. Recent studies of the human microbiome have illustrated dynamic relationships of bacterial and viral populations with the host, which may potentiate the risk of bacterial meningitis.
APA, Harvard, Vancouver, ISO, and other styles
10

Smith, A. L. "Bacterial Meningitis." Pediatrics in Review 14, no. 1 (January 1, 1993): 11–18. http://dx.doi.org/10.1542/pir.14-1-11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Bacterial meningitis"

1

Beek, Diederik van de. "Bacterial meningitis in adults." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/72440.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Atobe, Jane Harumi. "Amplificação de DNA de Neisseria meningitidis em amostras de líquido cefalorraquidiano pela reação em cadeia da polimerase-multiplex." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-11082006-115017/.

Full text
Abstract:
Padronizou-se a PCR-Multiplex para a detecção do DNA de Neisseria meningitidis. Para tanto os primers escolhidos foram: RW01, DG74 e COR28 baseados na subunidade menor do ribossomo (16S rRNA) que apresenta regiões de seqüências conservadas encontradas em todas as bactérias conhecidas. Os primers RW01 e DG74 amplificaram o fragmento universal bacteriano de 370 bp e, os primers RW01 e COR28, o fragmento específico de N. meningitidis de 279 bp em uma única etapa. Os resultados obtidos nas amostras de LCR de 168 pacientes pelos métodos de cultura e PCR-Multiplex quando comparados à bacterioscopia mostraram que tal técnica apresentou alta sensibilidade (91,3%) no estudo de amostras de LCR de bacterioscopia positiva, enquanto que a cultura apresentou resultados menores (19,7%). Nas amostras de LCR com bacterioscopia negativa a sensibilidade da PCR-Multiplex (57,8%) também foi mais elevada do que da cultura (10%). Estes dados sugerem que a técnica aqui padronizada é altamente promissora para ser utilizada como método diagnóstico da meningite meningocócica, especialmente nos casos de pacientes submetidos à terapia antibiótica prévia.
The PCR-multiplex technique was standardized to detect N.meningitidis DNA. It was used universal primer for all bacteria showing sequence of minor subunit of 16S ribossome regions (RW01, DG74) by amplification of 370bp fragment and another (COR28) for specific sequence of N. meningitidis, amplifying 279bp fragment in one step. The results obtained in CSF samples of 168 patients by culture and PCR-Multiplex technique when compared with microscopy showed high sensitivity (91,3%) in samples with positive microscopy (81) to Gram negative diplococcus, however the culture presented only 19, 7% of positivity in the same samples. In other hand the CSF samples with negative bacterioscopy (67) the PCR-Multiplex sensitivity (57,8%) was higher to culture (10,0%) too. These data indicate a high sensitivity and specificity of PCR as a tool for a rapid diagnosis of meningococcal meningitis, mainly in that patient submitted to previous antibiotic therapy as in case of this work (90% of patients) besides the possibility of a rational practice of specific treatment.
APA, Harvard, Vancouver, ISO, and other styles
3

Al, Jindan Reem Yussuf. "Hearing loss and bacterial meningitis." Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499828.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Winter, Andrew John. "Hearing loss in experimental bacterial meningitis." Thesis, University of Birmingham, 1997. http://etheses.bham.ac.uk//id/eprint/32/.

Full text
Abstract:
Experimental meningitis was induced in pigmented guinea pigs by subarachnoid inoculation of \(1 \times 10^9\) Escherichia coli K-12 or \(3 \times 10^7\) CFU Streptococcus pneumoniae serotype 2 D39 (NCTC 7466) or PLN-A, \(\Delta\)NA1 or \(\Delta\)HY1, defined isogenic derivatives of D39 deficient in pneumolysin, neuraminidase or hyaluronidase respectively. All animals developed a meningeal inflammatory response and a labyrinthitis. Hearing loss in pneumococcal meningitis was measured by recording the evoked auditory nerve compound action potential from the round window membrane. Animals infected with PLN-A sustained significantly less hearing loss than those infected with wild-type D39 (12 dB vs. 50 dB 12 h post inoculation; P<0.0001), Neuraminidase deficiency did not alter the course of the meningeal inflammatory response nor affect hearing loss. The \(\Delta\)HY1 mutant survived poorly in the cerebrospinal fluid and blood but still caused hearing loss. Both pneumococcal and E. coli meningitis induced specific ultrastructural lesions in the organ of Corti as judged by high-resolution scanning and transmission electron microscopy, and these lesions were most severe with pneumolysin-sufficient pneumococcal infection. Microperfusion of \(5\times10^6\) CFU S.pneumoniae D39 directly into the scala tympani of guinea pigs also resulted in electrophysiological and ultrastructural damage to the organ of Corti that could be diminished by pretreatment with antibiotics. The data confirm the cochlea as the site of meningogenic deafness. They suggest that pneumolysin expression is chiefly responsible for meningogenic deafness and that if pneumococci invade the inner ear during bacterial meningitis, cochlear deafhess will rapidly ensue.
APA, Harvard, Vancouver, ISO, and other styles
5

Alves, Danilo Antonini 1987. "Utilização de sílica mesoporosa como adjuvante em vacinas de vesícula de membrana externa de Neisseria meningitidis." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314457.

Full text
Abstract:
Orientador: Marcelo Lancellotti
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-19T19:47:46Z (GMT). No. of bitstreams: 1 Alves_DaniloAntonini_M.pdf: 4789463 bytes, checksum: cb7f3cabfd7df63e9dc00316cb7c8a10 (MD5) Previous issue date: 2012
Resumo: Vesículas da membrana externa ou outer membrane vesicles (OMV) são nanopartículas liberadas no meio de cultura durante o crescimento bacteriano resultantes de evaginações da membrana externa. A OMV é composta por antígenos presentes na membrana externa bacteriana, como porinas e lipo-oligossacarídeos - LOS, proporcionando a estas estruturas um efeito imuno-estimulatório, sendo alvo potencial para a produção de vacinas. Este trabalho teve como objetivo analisar a utilização de OMV de Neisseria meningitidis IAL 2443, linhagem pertencente ao sorogrupo B causadora de meningites no estado de São Paulo, com nanopartículas de sílica mesoporosa SBA-15 e SBA-16 no processo de imunização vacinal. Utilizou-se o processo fermentativo em estado semi-sólido para o crescimento bacteriano e um processo de ultracentrifugação para isolamento da OMV. Comparou-se a produção de OMV de linhagens de N. meningitidis selvagens IAL 2443 e C2135 e mutante knock-out para o gene responsável pela produção de pilina - C2135_pilE. A atividade imunológica foi verificada por meio da imunização em camundongos Swiss e a verificação da citotoxicidade foi realizada em cultura celular utilizando células VERO e NHI 3T3. Os resultados mostraram que as diferentes linhagens de N. meningitidis possuem cinéticas de produção de OMVs distintas em tempo e quantidade. A não expressão de pilE também afeta a cinética da produção dessas estruturas. O uso de adjuvantes de sílica mesoporosa SBA- 15 e SBA- 16 com a OMV IAL 2443 aumenta o reconhecimento pelo sistema imunológico, consequentemente elevando o número de anticorpos específicos frente a mesma cepa bacteriana e a outras linhagens do mesmo sorotipo e sorotipos diferentes. O teste de citotoxicidade em células VERO e NHI 3T3 demonstrou inocuidade nas preparações com SBA- 15 e SBA- 16, atestando a segurança no uso destas preparações como adjuvantes vacinais. O estudo demonstrou que a metodologia utilizada para produção de OMV é vantajosa do ponto de vista quantitativo e econômico e o uso de SBA- 15 e SBA- 16 apresenta potencial como adjuvante em vacinas baseadas em OMV
Abstract: Outer membrane vesicles or OMV are nanoparticles released into the culture medium during bacterial growth resulting from evaginations of the outer membrane. The OMV consists of antigens present in the bacterial outer membrane, like porins and lipooligosaccharides - LOS, these structures provide an immuno-stimulatory effect, and potential target for vaccine production. This study aimed to analyze the use OMV of Neisseria meningitidis IAL2443, belonging to serogroup B strain causing meningitis in São Paulo, as vaccine using the mesoporous silica SBA-15 and SBA-16 in the immunization process. Fermentation process was used in semi-solid state for bacterial growth and a process of ultracentrifugation for the isolation these OMV. It was compared to OMV production of strains of N.meningitidis strains IAL 2443 and C2135, and knock-out mutant for the gene responsible for producing pilin - C2135_pilE. The immunological activity was measured by immunization in Swiss mice and verification of cytotoxicity was performed in cell culture using VERO cells and NIH 3T3. The results showed that different strains of N. meningitidis have OMVs kinetics of production of different time and quantity. The expression does not pile also affects the kinetics of production of these structures. The use of adjuvants mesoporous silica SBA-15 and SBA-16 with the IAL2443 OMV increases the recognition by the immune system, thus bringing the number of specific antibodies against the same bacterial strain and other strains of the same serotype and different serotypes. The cytotoxicity test in NIH 3T3 cells showed VERO and safety in preparation adjuvanted with SBA-15 and SBA-16, confirming the safe use of these preparations as vaccine adjuvants. The study showed that the methodology used for the production of OMV is advantageous from the point of view of quantity and cost and use of SBA-15 and SBA-16 has potential as an adjuvant in vaccines based on OMV
Mestrado
Bioquimica
Mestre em Biologia Funcional e Molecular
APA, Harvard, Vancouver, ISO, and other styles
6

Richardson, Martin Paul. "Hearing loss during bacterial meningitis in children." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243780.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Abdalla, Hana Khidir. "Modulation of inflammatory mediators during experimental bacterial meningitis /." Linköping : Department of Molecular and Clinical Medicine, Linköping university, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med907s.pdf.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Diab, Asim Eltayeb. "Experimental bacterial meningitis : studies on immunopathogenesis and immunoregulation /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3008-2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Thomas, Karla Mari. "Bacterial meningitis in neonates and children South Africa." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/10743.

Full text
Abstract:
Includes bibliographical references.
Acute bacterial meningitis is defined as the inflammation of the meninges. It is caused by various bacteria and the specific aetiology is age dependant. In the neonatal period the causative organisms are: Group B streptococci, Gram - negative bacilli (e.g.: E. coli, Klebsiella spp, Enterobacter spp, Salmonella spp) and Listeria monocytogenes. In infants and children up to the age of 5 the most common causative organisms include: Streptococcus pneumoniae, Haemophilus influenzae type B (Hib)and Neiseria meningitidis. The two chief causes of bacterial meningitis in children older than 5 are S. pneumoniae and N. meningitidis. Various studies have been performed to look at the profile of meningitis among the paediatric population. Objective: To investigate the aetiology of acute bacterial meningitis in South African newborns and children from 2005 - 2010.
APA, Harvard, Vancouver, ISO, and other styles
10

Raza, Muhammad Waqar. "Viral infections as predisposing factors for bacterial meningitis." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/20135.

Full text
Abstract:
Epidemiological data suggest that viral infections might be predisposing factors for bacterial meningitis and carriage of type b Haemophilus influenzae (Hib), Neisseria meningitidis or Streptococcus pneumoniae, the three pathogens most commonly associated with bacterial meningitis. Non-secretors of ABO blood group antigens are over-represented among patients with bacterial meningitis and in populations affected by some outbreaks. The first objective of the study was to examine the hypothesis that non-secretors were also over-represented among patients with respiratory viral infections. Compared with the local population, there was a significantly higher proportion of secretors among patients with disease due to respiratory syncytial virus (RSV), influenza A virus, rhinovirus and ECHO virus. The hypothesis that Leb and/or H-type 1 antigens present on cells or in body fluids of secretors might be receptor(s) for RSV was examined. Affinity purified molecules with Leb or H type 1 determinants or synthetic receptor analogues did not decrease the infectivity of RSV for HEp-2 cells. Bacterial attachment to mucosal surfaces is an important prerequisite for infection. The second major objective was to assess the effect of RSV infection of HEp-2 cells (a human epithelial cell line) on binding of bacteria responsible for meningitis. Binding of bacteria labelled with fluorescein isothiocyanate (FITC) to HEp-2 cells and RSV-infected HEp-2 cells was compared by flow cytometry. Strains of meningococci (3) and Hib (5) expressing antigens of different serogroups, serotypes and subtypes and a strain of Staphylococcus aureus bound significantly more effectively to virus infected cells. Similar patterns of increased binding of unlabelled meningococci to monolayers of RSV-infected cells were also observed. Studies to identify the changes on the cell surface associated with RSV infection responsible for enhanced binding were carried out with one strain of meningococcus. Viral infection of HEp-2 cells did not enhance the expression of Lewisa antigen, a proposed receptor for bacteria in non-secretors. Monoclonal antibodies to the attachment glycoprotein G of RSV decreased the bacterial binding to infected HEp-2 cells; but monoclonal antibodies to the fusion glycoprotein F did not affect binding.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Bacterial meningitis"

1

Ireland. Working Group on Bacterial Meningitis and Related Conditions. Report of Working Group on Bacterial Meningitis and Related Conditions. Dublin: Department of Health, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Winter, Andrew John. Hearing loss in experimental bacterial meningitis. Birmingham: University of Birmingham, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Institut national de la santé et de la recherche médicale (France). Méningites bactériennes: Stratégies de traitement et de prévention. Paris: INSERM, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Modaï, J. Present-day antibiotic treatment of bacterial meningitis. Basel: Editiones "Roche", 1990.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Ireland. Department of Health. Working Group on Bacterial Meningitis and Related Conditions. Report of the Working Group on Bacterial Meningitis nd Related Conditions. Dublin: Department of Health, 1997.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Parker, James N., and Philip M. Parker. Bacterial meningitis: A medical dictionary, bibliography, and annotated research guide to Internet references. San Diego, CA: ICON Health Publications, 2004.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Drew, Shelley. Hearing loss induced by bacterial meningitis: Investigations into the possible involvement of, (i) bacterial ototoxins, (ii) nitric oxide, excitotoxicity, and reactive oxygen species. Birmingham: University of Birmingham, 1999.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

Amaee, Farzin. Deafness in bacterial meningitis: Ototoxic potential of Haemophilus influenzae type b cell fractions, pneumolysin and nitric oxide. Birmingham: University of Birmingham, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Noah, Norman. Surveillance of bacterial meningitus in Europe 1995. London: Department of Public Health & Epidemiology, King's College School of Medicine & Dentistry, 1996.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Singhi, Pratibha, Naveen Sankhyan, and Sunit Singhi. Acute Bacterial Meningitis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0144.

Full text
Abstract:
Bacterial meningitis is one of the severest infections in childhood. Neuronal damage in meningitis is largely due to the extensive inflammatory cascade induced by pathogenic bacteria. This chapter discusses the current understanding of the interaction of multitude of factors in the pathogenesis of bacterial meningitis. This includes the mechanisms involved in transcellular traversal of the bacteria, and induction and release of several inflammatory cytokines and chemokines. The management of a child with bacterial meningitis requires meticulous supportive care and timely, appropriate, and adequate antibiotic therapy. The chapter also reviews the current understanding of some important clinical aspects of care of a child with bacterial meningitis.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Bacterial meningitis"

1

Choi, Chester. "Bacterial Meningitis." In Infectious Disease in the Aging, 113–24. Totowa, NJ: Humana Press, 2001. http://dx.doi.org/10.1007/978-1-59259-026-1_11.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Abulhasan, Yasser B., and Pravin Amin$. "Bacterial Meningitis." In Neurointensive Care, 185–200. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-17293-4_12.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Pfister, Hans-Walter, Karen L. Roos, and Thomas P. Bleck. "Bacterial Meningitis." In Neurocritical Care, 377–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-87602-8_36.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Sprigings, David, and John L. Klein. "Bacterial meningitis." In Acute Medicine - A Practical Guide to the Management of Medical Emergencies, 5th Edition, 422–27. Chichester, UK: John Wiley & Sons, Ltd, 2017. http://dx.doi.org/10.1002/9781119389613.ch68.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Gooch, Jan W. "Bacterial Meningitis." In Encyclopedic Dictionary of Polymers, 877. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13223.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Chaubey, Vikas P., Kevin B. Laupland, Christopher B. Colwell, Gina Soriya, Shelden Magder, Jonathan Ball, Jennifer M. DiCocco, et al. "Bacterial Meningitis." In Encyclopedia of Intensive Care Medicine, 285. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1191.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Domachowske, Joseph, and Manika Suryadevara. "Bacterial Meningitis." In Clinical Infectious Diseases Study Guide, 177–85. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50873-9_28.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Huang, Felicia Scaggs, Rebecca C. Brady, and Joel Mortensen. "Bacterial Meningitis." In Introduction to Clinical Infectious Diseases, 245–57. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-91080-2_23.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Stechenberg, Barbara. "Bacterial Meningitis." In The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes, 193–98. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-391-2_13.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Prabhakar, Sudesh. "Acute bacterial meningitis." In International Neurology, 227–30. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118777329.ch58.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Bacterial meningitis"

1

Miyahira, Clara Kimie, and Vania Maria Sabadoto Brienze. "Comparative analysis between the profile of cerebrospinal liquid (CSF) and clinical evolution in patients with bacterial meningitis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.023.

Full text
Abstract:
Background: Bacterial meningitis is a serious infection that occurs in the Central Nervous System, which presents important morbidity and mortality, mainly in children. The main bacterial agents causing meningitis in the community are Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae. Specific signs and symptoms suggest meningitis and cerebrospinal fluid analysis is the main exam leading to diagnosis. Objectives: To analyze the behavior of cerebrospinal fluid during the evolution of the patient with bacterial meningitis. Methods: A retrospective study revised the medical records of patients with bacterial meningitis confirmed by cerebrospinal fluid examination in the Base Hospital of São José do Rio Preto from January 1996 to December 2002. Results: in the 63 Patients, there were 18 cases (28.6%) of S. pneumoniae, 20 cases (31.7%) of H. influenzae, 12 cases (19%) of N.meningitides B and 13 (20.6%) cases of N. meningitidis C. In the 18 patients with pneumococcus, 10 (55.6%) were discharged and 8 (44.4%) died. In the 20 patients with HIB, only 3 (15%) died, there was no death patients with meningococcus B and C. Conclusion: There was no difference statistics in the cerebrospinal fluid of the patients who were discharged and those who died.
APA, Harvard, Vancouver, ISO, and other styles
2

Teles, Daniel Rocha Diniz, Sabrina de Freitas Barros Soares, Paloma Fernandes de Oliveira, Matheus Gomes Diniz e. Silva, and Antonio Fernando Soares Menezes Segundo. "Epidemiological profile of bacterial meningitis in the state of São Paulo." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.079.

Full text
Abstract:
Introduction: Meningitis is an inflammatory process of the meninges, which can be of infectious cause or not. Among the infectious, the bacterial is the most alarming for society, since it has a much higher rate of morbidity and mortality. Objectives: Analyze and describe the epidemiological profile of bacterial meningitis in the State of São Paulo. Methods: Descriptive epidemiological study of cases of bacterial meningitis in the State of São Paulo, carried out through the DATASUS platform, in the period from 2016 to 2020. Results: The State of São Paulo registered 4013 cases of bacterial meningitis, 67.1% of the cases in the Southeast (5977), being responsible for 53% of the cases of this disease in Brazil. The most affected age group in the State was 0 to 4 years, 33.7% of the total, while elderly people aged 80 and over were the least affected (2.3%). As for deaths, São Paulo recorded 862 and a mortality rate of 21.4%, higher than the country average (20.5%), representing 64% of deaths in the Southeast region. In addition, males were the most affected, registering 58.1% of the total, while females registered 41.8%. Conclusions: São Paulo has the majority of cases and deaths from bacterial meningitis in its region, with a mortality rate that exceeds Brazilian averages and which contributes to the Southeast having more than half of the cases of meningitis in Brazil. More active epidemiological surveillance and greater dissemination of information on meningitis and its signs and symptoms is necessary.
APA, Harvard, Vancouver, ISO, and other styles
3

Giers, A., and C. Arens. "Neuroendocrine carcinoma as a rare cause of bacterial meningitis." In Abstract- und Posterband – 89. Jahresversammlung der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Hals-Chirurgie e.V., Bonn – Forschung heute – Zukunft morgen. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1640026.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Topor, A., S. Malin, F. Babarada, C. Ravariu, A. Salageanu, I. Caras, D. Manuc, and B. Patrichi. "Applications of images processing algorithms for bacterial meningitis diagnosis: Bacterial image processing in Mathlab." In 2017 9th International Conference on Electronics, Computers and Artificial Intelligence (ECAI). IEEE, 2017. http://dx.doi.org/10.1109/ecai.2017.8166447.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Revett, K., F. Gorunescu, and M. Ene. "A Machine Learning Approach to Differentiating Bacterial From Viral Meningitis." In IEEE John Vincent Atanasoff 2006 International Symposium on Modern Computing (JVA'06). IEEE, 2006. http://dx.doi.org/10.1109/jva.2006.2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Yeung, M., S. G. Chulani, and S. Desai. "Isolated Congenital Asplenia Presenting in an Adult with Bacterial Meningitis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6880.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Azeredo, Saulo, Emanuel Kerber, Yasmynni Escher, Artur Martio, and Victor Angeliero. "Meningitis: etiological and outcome panorama in Brazil in the 2019-2020 biennium." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.408.

Full text
Abstract:
Background: Meningitis is the inflammation of the meninges. The outcome varies between etiologies. It is endemic in Brazil with mandatory notification. Objectives: To analyze the number of diagnoses and outcomes of meningitis in Brazil in the 2019-2020 biennium. Design and setting: Cross-sectional epidemiological study using DATASUS database. Methods: Data from patients diagnosed with meningitis in the period from 2019 to 2020 were included, correlating them to the etiologies and their outcomes. Results: There was a 70.8% reduction in the absolute number of diagnosed meningitis in 2020 (4,713) compared to 2019 (16,155). The most prevalent specified cause was “viral meningitis”, corresponding to 49,1% in 2019 and 42% in 2020. There was no great variation in the percentage of etiologies. “Hospital discharge”, corresponding to 76.8% in 2019 and 68% in 2020. “Death” was the outcome of 14.8% of patients in 2020 and 12.9% in 2019. The most related option to “Death from meningitis” was “Bacterial meningitis”, responsible for 24% in 2020 and 21.3% in 2019. Conclusions: The number of diagnoses of meningitis fell in the 2019-2020 comparison. The context of under-diagnosis worries because it means late diagnoses and worse outcomes.
APA, Harvard, Vancouver, ISO, and other styles
8

Reis, Luana Brandão de Sales, Beatriz do Nascimento Garcia Moreno, Ricardo Moreno do Carmo Junior, João Guilherme Santos Garrido, and João Gustavo dos Anjos Morais Oliveira. "Elucidating the relationship between meningitis and SARSCoV-2 infection: a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.622.

Full text
Abstract:
Background: The Covid-19 pandemic has become a major challenge for public health, once this disease can even affect the nervous system, causing severe conditions, such as meningitis. The association between meningitis and Covid- 19 is not yet well established, but it is believed that it can be caused both by a bacterial co-infection or by the involvement of meninges due to the action of the virus itself. Objective: The aim of the present study is to elucidate the relationship between meningitis and SARS-CoV-2 infection. Methods: In order to carry out a literature review, case reports were searched in the PUBMED database, in which only articles in English were considered, without year restriction, resulting in the following research formula: “((COVID-19) OR (SARS-CoV-2)) AND (meningitis)”. Results: 33 case reports were found, of which only 12 met the eligibility criteria. The reported cases provide evidence of meningeal and brain involvement by the SARS-CoV-2 virus, some with confirmation by CSF RT-PCR. Isolation of the SARS-CoV-2 virus in the CSF is challenging and has not been possible in other patients; however, the exclusion of bacterial involvement by culture and other viral agents in the CSF analysis points to infection by SARS-CoV-2 in a patient with positive RT-PCR by nasopharyngeal swab or bronchoalveolar lavage. Conclusions: The possibility of SARS-CoV-2 meningitis reinforces the need to investigate this condition in patients with COVID-19 who have neurological symptoms.
APA, Harvard, Vancouver, ISO, and other styles
9

Azeredo, Saulo, Emanuel Kerber, Yasmynni Escher, Artur Martio, and Victor Angeliero. "Meningitis: etiological and outcome panorama in Brazil in the 2019-2020 biennium." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.404.

Full text
Abstract:
Background: Meningitis is the inflammation of the meninges. The outcome varies between etiologies. It is endemic in Brazil with mandatory notification. Objectives: To analyze the number of diagnoses and outcomes of meningitis in Brazil in the 2019-2020 biennium. Design and setting: Cross-sectional epidemiological study using DATASUS database realized by Neurology department of the University of Passo Fundo. Methods: Data from patients diagnosed with meningitis in the period from 2019 to 2020 were included, correlating them to the etiologies and their outcomes. Results: There was a 70.8% reduction in the absolute number of diagnosed meningitis in 2020 (4,713) compared to 2019 (16,155). The most prevalent specified cause was “viral meningitis”, corresponding to 49,1% in 2019 and 42% in 2020. There was no great variation in the percentage of etiologies. “Hospital discharge”, corresponding to 76.8% in 2019 and 68% in 2020. “Death” was the outcome of 14.8% of patients in 2020 and 12.9% in 2019. The most related option to “Death from meningitis” was “Bacterial meningitis”, responsible for 24% in 2020 and 21.3% in 2019. Conclusions: The number of diagnoses of meningitis fell in the 2019-2020 comparison. The context of under-diagnosis worries because it means late diagnoses and worse outcomes.
APA, Harvard, Vancouver, ISO, and other styles
10

Ramos, Miguel Bertelli, Frederico Arriaga Criscuoli de Farias, Manoel Jacobsen Teixeira, and Eberval Gadelha Figueiredo. "The Most Influential Papers in Infectious Meningitis Research: A Bibliometric Study." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.453.

Full text
Abstract:
Background: Bibliometric analyses allow detecting citation trends within a field, including assessments of the most cited journals, countries, institutions, topics, types of study, and authors. Objectives: To perform a bibliometric analysis of the 100 most cited papers within infectious meningitis research. Methods: The 100 most cited publications and their data were retrieved from Scopus and Web of Science during 2019. Results: The New England Journal of Medicine had the greatest number of articles (27) and citations (12,266) in the top 100. Articles were mainly published after the late 1980s. Bacteria were the most discussed agents (72 articles and 26,362 citations), but Cryptococcus sp represented the most-discussed single agent (16 articles and 6,617 citations). Primary research represented 70 articles and 25,754 citations. Among them, the most discussed topic was Clinical Features and Diagnosis/Outcomes (22 articles and 8,325 citations). Among the 27 secondary research articles, the most common type of study was Narrative Review (18 articles and 5,685 citations). The United States was the country with the greatest number of articles (56) and citations (21,388). Centers for Disease Control and Prevention (CDC) and Yale University had the greatest number of articles (six each), being CDC the most cited (3,559). Conclusions: The most cited articles within meningitis research are primary research studies, more frequently published in high IF journals and by North American institutions. Bacterial meningitis comprises the majority of publications. The articles were mainly published after the AIDS pandemic and after the implementation of the main vaccines for meningitis.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Bacterial meningitis' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography