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Dissertations / Theses on the topic 'Bacteriophage, Staphylococcic'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 January 2023

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1

Messad, Nourreddine. "Staphylococcus aureus colonisant / Staphylococcus aureus infectant dans le modèle du pied diabétique." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT063/document.

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Staphylococcus aureus est l’un des principaux agents étiologiques des infections suppuratives superficielles et profondes ainsi que des syndromes liés à l’action de toxines. Paradoxalement, cette bactérie est un agent commensal qui est présent sur la peau ainsi que dans les cavités nasales notamment. Cela permet de considérer cette bactérie comme un organisme colonisant commensale. Les bases génétiques expliquant la différence entre une bactérie pathogène et une bactérie commensale reste inconnues. En utilisant la technique Optical Maps sur des souches de S. aureus isolées de plaies de pieds d
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2

Montero, Diez Cristina. "Functional characterization of a bacteriophage-encoded inhibitor of Staphylococcus aureus transcription." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11068.

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3

Alves, Diana R. "Development and characterisation of a responsive polyvalent bacteriophage therapeutic." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.675705.

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Bacteriophages (phages) are obligate intracellular parasites of bacteria that usually kill the bacterial host. Bacteriophage therapy is a recently revived approach for treating bacterial infection that relies on the traits of the phage lytic cycle. A lot of attention has been given to phage therapy with new research being published weekly and international conferences organised every year, bringing together the academic and industrial phage communities. However, despite this huge effort and considerable scientific interest there is still a great lack of understanding on how to use phage effect
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4

Lane, Kristin. "Transcriptional crosstalk between helper bacteriophages and Staphylococcal aureus pathogenicity islands." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3267.

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Acquisition of a superantigen pathogenicity island (SaPI) significantly increases virulence in Staphylococcus aureus. Horizontal transfer of SaPIs occurs at high frequency and depends upon a helper bacteriophage, either through direct infection or SOS-mediated induction of a lysogen. SaPIs hijack the packaging machinery of the helper phage, leading to the formation of SaPI-containing transducing particles that can introduce the pathogenicity island into neighboring SaPI-negative cells. All SaPIs contain a conserved core of genes, some of which are co-transcribed as an operon and encode functio
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5

Caufield, J. Harry. "N-TERMINAL PROCESSING OF RIBOSOMAL PROTEIN L27 IN STAPHYLOCOCCUS AUREUS." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/361.

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The bacterial ribosome is essential to cell growth yet little is known about how its proteins attain their mature structures. Recent studies indicate that certain Staphlyococcus aureus bacteriophage protein sequences contain specific sites that may be cleaved by a non-bacteriophage enzyme (Poliakov et al. 2008). The phage cleavage site was found to bear sequence similarity to the N-terminus of S. aureus ribosomal protein L27. Previous studies in E. coli (Wower et al.1998; Maguire et al. 2005) found that L27 is situated adjacent to the ribosomal peptidyl transferase site, where it likely a
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6

Chang, Jenny Ren-Jye. "Scaffolding-mediated capsid size determination in bacteriophages." Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/changj.pdf.

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Thesis (Ph. D.)--University of Alabama at Birmingham, 2009.<br>Title from PDF title page (viewed Jan. 26, 2010). Additional advisors: Asim K. Bej, Gail E. Christie, Peter E. Prevelige, Jr., R. Douglas Watson. Includes bibliographical references.
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7

Jensen, Kyle C. "Isolation and Host Range of Staphylococcus aureus Bacteriophages and Use for Decontamination of Fomites." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5508.

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Staphylococcus aureus is a common bacterium found on the skin and mucosal membranes of about 20% of the population. S. aureus growth on the skin is harmless, but if it bypasses the skin it can causes life-threatening diseases such as pneumonia, meningitis, bacteremia, and sepsis. Antibiotic-resistant strains of S. aureus, called Methicillin Resistant S. aureus (MRSA), are resistant to most antibiotics except vancomycin. However, vancomycin resistant strains of MRSA are becoming more common. In this study, 12 phages were isolated capable of infecting human S. aureus and/or MRSA strains. Five ph
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8

Birch-Machin, I. R. "Studies of typing bacteriophages 77, 52A and 47 of Staphylococcus aureus." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538935.

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9

Clem, Angela. "Bacteriophage for the elimination of methicillin-resistant staphylococcus aureus (MRSA) colonization and infection." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001568.

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10

Luckmini, Kaushalya Weerakoon Jayaswal Radheshyam K. "Molecular analysis of the upstream region of a lysin gene (lytA) of bateriophage 011 of Staphylococcus aureus." Normal, Ill. Illinois State University, 1995. http://wwwlib.umi.com/cr/ilstu/fullcit?p9633406.

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Thesis (Ph. D.)--Illinois State University, 1995.<br>Title from title page screen, viewed May 12, 2006. Dissertation Committee: Radheshyam K. Jayaswal (chair), Brian J. Wilkinson, Alan J. Katz, Herman E. Brockman, Anthony J. Otsuka. Includes bibliographical references (leaves 112-118) and abstract. Also available in print.
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11

Klenow, Laura. "Characterization of the Interactions between Staphylococcal Phage 80 Alpha Scaffold and Capsid Proteins." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3917.

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Staphylococcal phage 80α can serve as a helper bacteriophage for a family of mobile genetic elements called Staphylococcus aureus pathogenicity islands (SaPIs). The prototype island, SaPI1, is able to hijack the 80α capsid assembly process and redirect capsid formation to yield smaller, phage-like transducing particles carrying SaPI DNA. Capsid size redirection is accomplished through two SaPI1-encoded gene products, CpmA and an alternate scaffold protein, CpmB. The normal 80α scaffold and the SaPI1 CpmB scaffold share a small block of conserved residues at their C-termini, several of which ha
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12

Nassau, Tomas J. van [Verfasser], Rudi F. [Akademischer Betreuer] Vogel, Siegfried [Gutachter] Scherer, and Rudi F. [Gutachter] Vogel. "Combination of bacteriophage lysins and high hydrostatic pressure for the inactivation of Listeria monocytogenes and Staphylococcus aureus / Tomas J. van Nassau ; Gutachter: Siegfried Scherer, Rudi F. Vogel ; Betreuer: Rudi F. Vogel." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1159703302/34.

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13

El-Zarkout, Farah. "Design, construction and characterization of LysK endolysin display phage against Staphylococcus aureus." Thesis, 2013. http://hdl.handle.net/10012/8246.

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The growing threat of drug- resistant Staphylococcus aureus (S. aureus) infections mandates the need to develop novel, effective and alternative antibacterial therapeutics. Despite infection prevention and control measures, methicillin resistant S. aureus (MRSA)-associated deaths reached 11,285 in 2011 in the USA (CDC, 2013). To counteract the threat of drug resistant S. aureus, we sought to construct and characterize a novel therapeutic based on the display of lytic antibacterial enzymes, termed endolysins. These endolysins were displayed on the surface of a specific bacterial virus, bacteri
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14

Melo, Luís D. R. "Staphylococcus epidermidis bacteriophages: new insights on endolysins and phage-biofilm interactions." Doctoral thesis, 2014. http://hdl.handle.net/1822/35614.

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Tese de doutoramento em Engenharia Biomédica<br>The increasing numbers of healthcare-associated infections are alarming and have resulted in higher morbidity and mortality rates, which ultimately are a burden to the public health systems. Remarkably, it was reported that around 65% of these infections were caused by biofilms. Biofilms are microbial communities attached to a surface and surrounded by exopolymeric substances that form a complex structure. Nowadays it is known that the majority of microbes live within a structured biofilm and not as free-floating organisms. Staphylococcus e
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15

Drilling, Amanda Jane. "Bacteriophage therapy for application against Staphylococcus aureus infection and biofilm in chronic rhinosinusitis." Thesis, 2015. http://hdl.handle.net/2440/103502.

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Chronic rhinosinusitis (CRS) is a debilitating condition characterised by critical inflammation of the mucosa of the nose and paranasal sinuses. Effecting up to 14% of the world’s population CRS severely impacts a patient’s quality of life. The aetiology of CRS is complex and relatively undefined encompassing a multitude of contributing factors. Bacterial infection is one factor thought to play a role in the pathogenesis of CRS. More specifically biofilm forms of the bacterial species Staphylococcus aureus have been shown to negatively influence post-operative progression. Current practice tre
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16

Ozen, Aysu. "Construction of Bacteriophage-Based Bioluminescent Bioreporters for Staphylococcus aureus and Salmonella Monitoring." 2007. http://etd.utk.edu/2007/OzenAysu.pdf.

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17

Basdew, Iona Hershna. "Biological and molecular characterization of South African bacteriophages infective against Staphylococcus aureus subsp. aureus Rosenbach 1884, casual agent of bovine mastitis." Thesis, 2012. http://hdl.handle.net/10413/10088.

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Bacteriophage therapy has been exploited for the control of bacterial diseases in fauna, flora and humans. However, the advent of antibiotic therapy lead to a cessation of most phage research. Recently, the problem of antibiotic resistance has rendered many commonly used antibiotics ineffective, thereby renewing interest in phage therapy as an alternative source of control. This is particularly relevant in the case of bovine mastitis, an inflammatory disease of bovine mammary glands, caused by strains such as Staphylococcus aureus subsp. aureus Rosenbach 1884. Antibiotic resistance (primarily
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18

Vieira, Cátia Sofia Silva. "Antimicrobial photodynamic therapy potentiation by potassium iodide." Master's thesis, 2018. http://hdl.handle.net/10773/25771.

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With the global increasing and spreading of antibiotic-resistant microorganisms, there is a need to develop strategies capable of inactivating plantonic and biofilm-forms of pathogenic microorganisms that causes untreatable and mortal infections. Antimicrobial photodynamic therapy (aPDT) is an alternative approach capable of combating microorganisms independently of their resistance profile. Althought this technique presents great results and advantages, the neutral and monocationic photosensitizers (PS) do not usually kill efficiently gram-negative bacteria and fungi, and their synthetic prep
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