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Journal articles on the topic 'Bacteriophage, Staphylococcic'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 January 2023

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1

Kharaeva, Z. F., M. Sh Mustafaev, L. Z. Blieva, E. B. Barokova, S. M. Mustafaeva, and S. A. Dyshekova. "Evaluation of sensitivity to bacteriophages of strains isolated from children with congenital malformations of the maxillofacial region." REPORTS ADYGE (CIRCASSIAN) INTERNATIONAL ACADEMY OF SCIENCES 20, no. 1 (2020): 40–45. http://dx.doi.org/10.47928/1726-9946-2020-20-1-40-45.

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Bacteriophage are used in clinical practice along with antibiotics. It is known that in many cases phage drugs are superior to other antibacterial drugs in their activity against antibiotic-resistant pathogens. Bacteriophages do not cause toxic or allergic side effects and have no contraindications.The use of bacteriophage preparations stimulates the activation of adaptive and innate immune factors, so phage therapy is particularly effective in the treatment of chronic inflammatory diseases against the background of immunosuppressive States. Bacteriophages do not interfere with the implementat

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Horiuk, Yu V. "Lytic Activity of Staphylococcal Bacteriophage on Different Biotypes of Staphylococcus aureus." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, no. 94 (July 30, 2019): 115–20. http://dx.doi.org/10.32718/nvlvet9421.

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Bacteriophage is a virus that infects a bacterium by injecting a phage genome into a bacterial cytoplasm and uses a host cell as a propagation mechanism. The studied models of phages show a narrow range of hosts. Previous studies on the investigation of lytic activity of staphylococcal bacteriophages were focused on determining the sensitivity of S. aureus isolated from patients from different clinical material and clinically healthy people. However, there is no information as to how refractory are the already described agents against S. aureus ecovars, isolated from animals. The purpose of th

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Vorobey, E. S., O. S. Voronkova, and A. I. Vinnikov. "Correction of vaginal dysbiosis in mice caused by a film-forming strain Staphylococcus aureus, using bacteriophages and probiotics." Regulatory Mechanisms in Biosystems 8, no. 2 (April 29, 2017): 252–58. http://dx.doi.org/10.15421/021739.

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The complex use of bacteriophages and probiotics is a promising trend in improving prevention and treatment of gynecological lesions. Our study of their influence on the microflora was performed on the model of vaginal dysbiosis of white laboratory mice induced by introduction of a filmforming strain of Staphylococcus aureus. For correction of dysbiosis, staphylococcal bacteriophage liquid, piobacteriophage polyvalent, intesti-bacteriophage liquid and probiotic "Vahilak" were used. For the identification of the microflora of the reproductive tract, samples of biological material from the vagin

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Martykanova, Dilyara, Ilya Zemlenuhin, Ollga Reshetnik, Dilyara Kamaldinova, and Nailya Davletova. "Sensitivity of staphylococcus microflora of wrestlers’ skin to bacteriophages." SCIENCE AND SPORT: current trends 7, no. 3 (September 2019): 136–41. http://dx.doi.org/10.36028/2308-8826-2019-7-3-136-141.

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The purpose of this study was to identify the characteristics of bacteriocenosis of wrestlers’ skin and to determine the sensitivity of staphylococcal microflora to bacteriophages. Methods and organization of the research. The experiment involved 15 athletes aged 17-21 years engaged in national wrestling and belt wrestling. Qualifications ranged from 1st adult rank to the master of sports. We used the method of microbiological seeding on yolk-salt agar (JSA) to analyze the washes from the intact skin of the medial part of forearms of wrestlers before and immediately after training. We identifi

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Levanova, L. A., Yu V. Zakharova, A. A. Markovskaya, and L. Yu Otdushkina. "Bacteriophage sensitivity of opportunistic microbiota in children with gut dysbiosis." Fundamental and Clinical Medicine 7, no. 3 (September 30, 2022): 40–45. http://dx.doi.org/10.23946/2500-0764-2022-7-3-40-45.

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Aim. As the activity of bacteriophages is species- and strain-specific, it is necessary to study bacteriophage sensitivity in distinct geographic regions with various disease patterns. Here, we aimed to study the lytic activity of specific commercially available bacteriophages against Klebsiella spp., Proteus spp., and Staphylococcus aureus isolated from the intestines of children with gut dysbiosis.Materials and Methods. Bacteriophage sensitivity was assessed in 315 opportunistic microorganisms (125 Staphylococcus aureus strains, 120 Klebsiella spp. strains, 70 Proteus spp. strains) isolated

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Horiuk, Y., M. Kukhtyn, V. Horiuk, S. Kernychnyi, and L. Tarasenko. "Characteristics of bacteriophages of the Staphylococcus aureus variant bovis." Veterinární Medicína 65, No. 10 (October 29, 2020): 421–26. http://dx.doi.org/10.17221/55/2020-vetmed.

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Bacteriophages may be an alternative method of treatment for antibiotic-resistant bacteria, including mastitis in cows. Our study describes the initial isolation and bacteriological activity of bacteriophages, circulating on dairy farms, the against S. aureus var. bovis. Samples of cow’s milk secretions with signs of mastitis and sewage water were used as the study material. The isolation and production of pure bacteriophage lines were performed according to the double agar method. The method of studying a single cycle of phage reproduction was used to determine the duration of the latency per

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Rybalkin, M. V., N. V. Khokhlenkova, and К. Yе Nikiforova. "The study of the effectiveness of the antibacterial action of the combination of a bacteriophage with a probiotic." News of Pharmacy 103, no. 1 (February 7, 2022): 60–65. http://dx.doi.org/10.24959/nphj.22.83.

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Intestinal infections occupy one of the leading places in diseases of the gastrointestinal tract in humans and animals. Strains of Staphylococcus spp are one of the causative agents of an intestinal infection. When treating an intestinal infection caused by staphylococcus, antibiotics are most often used, but in recent years there has been the formation of resistance in staphylococcus strains to antibiotics that have been used for many years. One of the promising ways to solve the problem of antimicrobial resistance is the use of drugs based on bacteriophages, which have a specific effect on t

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Kuptsov, NS, MA Kornienko, RB Gorodnichev, DI Danilov, MV Malakhova, TV Parfenova, GI Makarenko, EA Shitikov, and EN Ilina. "Efficacy of commercial bacteriophage products against ESKAPE pathogens." CIRCULATING RNA, no. (3)2020 (May 25, 2020): 18–24. http://dx.doi.org/10.24075/brsmu.2020.029.

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The ever-rising prevalence of multidrug-resistant bacteria necessitates the search for a therapeutic alternative to antibiotics. Using therapeutic products based on virulent bacteriophages might provide such an alternative. The aim of our study was to evaluate the efficacy of commercial phage products and natural bacteriophage monoisolates recovered from environmental sources against clinical strains of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. We compiled a collection of 147 strains that were subsequently genotypes using the MLST method. T

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Aleksanina, N. V., and T. I. Tverdokhlebova. "Phage resistance of conditionally pathogenic intestinal microbiota bacteria in children with microbiocenosis disorders." Journal Infectology 13, no. 2 (July 14, 2021): 102–7. http://dx.doi.org/10.22625/2072-6732-2021-13-2-102-107.

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Objective: to study the circulation and prevalence of phage-resistant strains among opportunistic enterobacteria, isolated from children with disorders of intestinal microflora, in relation to domestic preparations of bacteriophages.Materials and methods. A bacteriological study of the fecal microflora of the colon in 970 young children for dysbiosis was carried out. The sensitivity of 720 antibiotic-resistant strains of opportunistic enterobacteriaceae (S. aureus, K. pneumoniae, P. mirabilis and P. vulgaris, P. aeruginosa, E. coli, coagulase-negative staphylococci) isolated from children to d

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Horiuk, Y. V., M. D. Kukhtyn, Y. S. Stravskyy, S. I. Klymnyuk, K. M. Vergeles, and V. V. Horiuk. "Influence of staphylococcal Phage SAvB14 on biofilms, formed by Staphylococcus aureus variant bovis." Regulatory Mechanisms in Biosystems 10, no. 3 (August 22, 2019): 314–18. http://dx.doi.org/10.15421/021948.

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The use of bacteriophages for the treatment of chronic inflammatory processes has proved to be relevant, especially during isolation of antibiotic-resistant pathogens formed in biofilms. The article presents the results of research on the influence of Phage SAvB14 on young and mature biofilms formed by Staphylococcus aureus variant bovis. In the experiments we used cultures of S. aureus and a specific Phage SAvB14 isolated from the secretion of the mammary gland of cows suffering from chronic mastitis. In the study of the influence of bacteriophage on formed biofilms we determined the optical

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Kimirilova, O. G., and G. A. Kharchenko. "Results of treatment of primary staphylococcal enterocolitis in infants with the use of antibacterial drugs and their combination with bacteriophages: a prospective study." CHILDREN INFECTIONS 20, no. 3 (October 6, 2021): 33–38. http://dx.doi.org/10.22627/2072-8107-2021-20-3-33-38.

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In infectious pathology in infants, staphylococcal infection occupies a leading place, is characterized by the rapid development of intoxication, a purulent-destructive process with the possibility of generalization of infection, affecting the course and outcome of the disease.The aim of the study was to study the results of treatment of primary staphylococcal enterocolitis, in infants, with the use of antibacterial drugs and their combination with bacteriophages.Research methods. The frequency of elimination of staphylococcus, the duration of the main symptoms (fever, diarrhea, toxicosis with

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Frosini, Sian Marie, Ross Bond, Alex J. McCarthy, Claudia Feudi, Stefan Schwarz, Jodi A. Lindsay, and Anette Loeffler. "Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens." Microorganisms 8, no. 12 (December 18, 2020): 2031. http://dx.doi.org/10.3390/microorganisms8122031.

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Transmission of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus pseudintermedius (MRSP) between people and pets, and their co-carriage, are well-described. Potential exchange of antimicrobial resistance (AMR) genes amongst these staphylococci was investigated in vitro through endogenous bacteriophage-mediated transduction. Bacteriophages were UV-induced from seven donor isolates of canine (MRSP) and human (MRSA) origin, containing tet(M), tet(K), fusB or fusC, and lysates filtered. Twenty-seven tetracycline- and fusidic acid- (FA-) susceptible recipi

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Mannala, GK, M. Rupp, N. Walter, M. Brunotte, F. Alagboso, D. Docheva, C. Brochhausen, and V. Alt. "Microbiological and ultrastructural evaluation of bacteriophage 191219 against planktonic, intracellular and biofilm infection with Staphylococcus aureus." European Cells and Materials 43 (February 24, 2022): 66–78. http://dx.doi.org/10.22203/ecm.v043a07.

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Infections of orthopaedic implants, such as fracture fixation devices and total-joint prostheses, are devastating complications. Staphylococcus aureus (S. aureus) is a predominant pathogen causing orthopaedic-implant biofilm infections that can also internalise and persist in osteoblasts, thus resisting antibiotic therapy. Bacteriophages are a promising alternative treatment approach. However, data on the activity of bacteriophages against S. aureus, especially during intracellular growth, and against in vivo biofilm formation on metals are scarce. Therefore, the present study evaluated the in

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Brown, Matthew, Alex Hall, Henriett Zahn, Marcia Eisenberg, and Stephen Erickson. "Bacteriophage-Based Detection of Staphylococcus aureus in Human Serum." Viruses 14, no. 8 (August 10, 2022): 1748. http://dx.doi.org/10.3390/v14081748.

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Bacteriophages have been investigated for clinical utility, both as diagnostic tools and as therapeutic interventions. In order to be applied successfully, a detailed understanding of the influence of the human matrix on the interaction between bacteriophage and the host bacterium is required. In this study, a cocktail of luciferase bacteriophage reporters was assessed for functionality in a matrix containing human serum and spiked with Staphylococcus aureus. The inhibition of signal and loss of sensitivity was evident with minimal amounts of serum. This phenotype was independent of bacterial

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15

Rai, Akanksha, and Krishna Khairnar. "Initial Survey of Staphylococcus Bacteriophages and Simple Modifications in the Enrichment Method for Enhancing Plaques." Research Journal of Biotechnology 17, no. 7 (June 25, 2022): 130–33. http://dx.doi.org/10.25303/1707rjbt1300133.

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Isolation of bacteriophages against Staphylococcus aureus is difficult when compared to the bacteriophages of other genera. We did a preliminary survey for the presence of bacteriophages of S. aureus and Escherichia coli in the environmental water samples. We did not get bacteriophages against S. aureus, but bacteriophages against E. coli were ample. Subsequently, a river-water sample was taken and through the enrichment method with some modifications, we got a bacteriophage against a methicillin-resistant S. aureus. Here, we are reporting simple changes in the enrichment method to enhance pla

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Grygorcewicz, Bartłomiej, Rafał Rakoczy, Marta Roszak, Maciej Konopacki, Marian Kordas, Agnieszka Piegat, Natalia Serwin, Elżbieta Cecerska-Heryć, Miroslawa El Fray, and Barbara Dołęgowska. "Rotating Magnetic Field-Assisted Reactor Enhances Mechanisms of Phage Adsorption on Bacterial Cell Surface." Current Issues in Molecular Biology 44, no. 3 (March 17, 2022): 1316–25. http://dx.doi.org/10.3390/cimb44030088.

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Growing interest in bacteriophage research and use, especially as an alternative treatment option for multidrug-resistant bacterial infection, requires rapid development of production methods and strengthening of bacteriophage activities. Bacteriophage adsorption to host cells initiates the process of infection. The rotating magnetic field (RMF) is a promising biotechnological method for process intensification, especially for the intensification of micromixing and mass transfer. This study evaluates the use of RMF to enhance the infection process by influencing bacteriophage adsorption rate.

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Zhou, Wenyuan, Hua Wen, Yajie Li, Yajun Gao, Xiangfeng Zheng, Lei Yuan, Guoqiang Zhu, and Zhenquan Yang. "Whole-Genome Analysis Reveals That Bacteriophages Promote Environmental Adaptation of Staphylococcus aureus via Gene Exchange, Acquisition, and Loss." Viruses 14, no. 6 (May 31, 2022): 1199. http://dx.doi.org/10.3390/v14061199.

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The study of bacteriophages is experiencing a resurgence owing to their antibacterial efficacy, lack of side effects, and low production cost. Nonetheless, the interactions between Staphylococcus aureus bacteriophages and their hosts remain unexplored. In this study, whole-genome sequences of 188 S. aureus bacteriophages—20 Podoviridae, 56 Herelleviridae, and 112 Siphoviridae—were obtained from the National Center for Biotechnology Information (NCBI, USA) genome database. A phylogenetic tree was constructed to estimate their genetic relatedness using single-nucleotide polymorphism analysis. Co

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Plota, Maria, Eleni Sazakli, Nikolaos Giormezis, Foteini Gkartziou, Fevronia Kolonitsiou, Michalis Leotsinidis, Sophia G. Antimisiaris, and Iris Spiliopoulou. "In Vitro Anti-Biofilm Activity of Bacteriophage K (ATCC 19685-B1) and Daptomycin against Staphylococci." Microorganisms 9, no. 9 (August 31, 2021): 1853. http://dx.doi.org/10.3390/microorganisms9091853.

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The purpose of the present study was to investigate anti-staphylococcal activity of daptomycin and bacteriophage K, alone or in combination, against biofilm-producers and non-producers S. aureus and S. epidermidis strains, under biofilm forming and cells’ proliferation conditions. Daptomycin and bacteriophage K (ATCC 19685B1), in different concentrations, were tested against 10 Staphylococcus aureus and 10 S. epidermidis, characterized by phenotypes and genotypes. The quantitative microtiter plate (crystal violet, CV), methylthiazoltetrazolium (MTT), and growth curve (GC) assays were performed

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Stipniece, Liga, Dace Rezevska, Juta Kroica, and Karlis Racenis. "Effect of the Biopolymer Carrier on Staphylococcus aureus Bacteriophage Lytic Activity." Biomolecules 12, no. 12 (December 14, 2022): 1875. http://dx.doi.org/10.3390/biom12121875.

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The use of implant materials is always associated with the risk of infection. Moreover, the effectiveness of antibiotics is reduced due to antibiotic-resistant pathogens. Thus, selecting the appropriate alternative antimicrobials for local delivery systems is correlated with successful infection management. We evaluated immobilization of the S. aureus specific bacteriophages in clinically recognized biopolymers, i.e., chitosan and alginate, to control the release profile of the antimicrobials. The high-titre S. aureus specific bacteriophages were prepared from commercial bacteriophage cocktail

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Crane, Adele, Joy Abaidoo, Gabriella Beltran, Danielle Fry, Colleen Furey, Noe Green, Ravneet Johal, et al. "The Complete Genome Sequence of the Staphylococcus Bacteriophage Metroid." G3 Genes|Genomes|Genetics 10, no. 9 (September 1, 2020): 2975–79. http://dx.doi.org/10.1534/g3.120.401365.

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Abstract Phages infecting bacteria of the genus Staphylococcus play an important role in their host’s ecology and evolution. On one hand, horizontal gene transfer from phage can encourage the rapid adaptation of pathogenic Staphylococcus enabling them to escape host immunity or access novel environments. On the other hand, lytic phages are promising agents for the treatment of bacterial infections, especially those resistant to antibiotics. As part of an ongoing effort to gain novel insights into bacteriophage diversity, we characterized the complete genome of the Staphylococcus bacteriophage

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Titze, Isabel, Tatiana Lehnherr, Hansjörg Lehnherr, and Volker Krömker. "Efficacy of Bacteriophages Against Staphylococcus aureus Isolates from Bovine Mastitis." Pharmaceuticals 13, no. 3 (February 26, 2020): 35. http://dx.doi.org/10.3390/ph13030035.

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The lytic efficacy of bacteriophages against Staphylococcus aureus isolates from bovine milk was investigated in vitro, regarding possible applications in the therapy of udder inflammation caused by bacterial infections (mastitis). The host range of sequenced, lytic bacteriophages was determined against a collection of 92 Staphylococcus (S.) aureus isolates. The isolates originated from quarter foremilk samples of clinical and subclinical mastitis cases. A spot test and a subsequent plaque assay were used to determine the phage host range. According to their host range, propagation and storage

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Samokhin, A. G., Ju N. Kozlova, D. V. Korneev, O. S. Taranov, E. A. Fedorov, V. V. Pavlov, V. V. Morozova, and N. V. Tikunova. "Experimental study of the antibacterial activity of the lytic Staphylococcus aureus bacteriophage ph20 and lytic Pseudomonas aeruginosa bacteriophage ph57 during modelling of its impregnation into poly(methylmetacrylate) orthopedic implants (bone cement)." Annals of the Russian academy of medical sciences 73, no. 1 (February 1, 2018): 59–68. http://dx.doi.org/10.15690/vramn905.

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Background: The problem of bacterial colonization of implants used in medical practice continues to be relevant regardless of the material of the implant. Particular attention deserves polymeric implants, which are prepared ex tempore from polymethyl methacrylate, for example - duting orthopedic surgical interventions (so-called "bone cement"). The protection of such implants by antibiotic impregnation is subjected to multiple criticisms, therefore, as an alternative to antibiotics, lytic bacteriophages with a number of unique advantages can be used - however, no experimental studies have been

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Burova, L., O. Korniychuk, S. Pavliy, and Y. Mazepa. "Comparative characteristics antimicrobial activity of different classes of antibiotics and antimicrobial isolates on Staphylococcus aureus." Reports of Vinnytsia National Medical University 24, no. 1 (May 18, 2020): 12–16. http://dx.doi.org/10.31393/reports-vnmedical-2020-24(1)-02.

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Annotation. S. aureus is a leading cause of nosocomial infections in health care facilities. The aim of the study was to determine the effectiveness of the use of staphylococcal bacteriophage, phytopreparation “Chlorophyllipt”, of the drug “Protargol”, compared with antimicrobial chemotherapeutic drugs (ACD) against isolates of Staphylococcus aureus in vitro. Used clinical strains of S. aureus, isolated from 20 patients, aged 19 to 25 years. The susceptibility of microorganisms to ACD was determined on the MPA medium by disk-diffusion method. Staphylococcal bacteriophage sensitivity scores wer

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Capparelli, Rosanna, Marianna Parlato, Giorgia Borriello, Paola Salvatore, and Domenico Iannelli. "Experimental Phage Therapy against Staphylococcus aureus in Mice." Antimicrobial Agents and Chemotherapy 51, no. 8 (May 21, 2007): 2765–73. http://dx.doi.org/10.1128/aac.01513-06.

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ABSTRACT The present study describes a bacteriophage (MSa) active against Staphylococcus aureus, including methicillin-resistant staphylococcal strains. When inoculated into mice simultaneously with S. aureus A170 (108 CFU/mouse), phage (109 PFU) rescued 97% of the mice; when applied to nonlethal (5 × 106 CFU/mouse) 10-day infections, the phage also fully cleared the bacteria. The phage MSa, delivered inside macrophages by S. aureus, kills the intracellular staphylococci in vivo and in vitro. The phage can also prevent abscess formation and reduce the bacterial load and weight of abscesses. Th

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Abbas, Rao Zahid, Abdullah F. Alsayeqh, and Amjad Islam Aqib. "Role of Bacteriophages for Optimized Health and Production of Poultry." Animals 12, no. 23 (December 1, 2022): 3378. http://dx.doi.org/10.3390/ani12233378.

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The poultry sector is facing infections from Salmonella, Campylobacter, Listeria and Staphylococcus spp., and Escherichia coli, that have developed multidrug resistance aptitude. Antibiotics cause disturbances in the balance of normal microbiota leading to dysbiosis, immunosuppression, and the development of secondary infections. Bacteriophages have been reported to lower the colonization of Salmonella and Campylobacter in poultry. The specificity of bacteriophages is greater than that of antibiotics and can be used as a cocktail for enhanced antibacterial activity. Specie-specific phages have

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Cha, Yoyeon, Jihwan Chun, Bokyung Son, and Sangryeol Ryu. "Characterization and Genome Analysis of Staphylococcus aureus Podovirus CSA13 and Its Anti-Biofilm Capacity." Viruses 11, no. 1 (January 12, 2019): 54. http://dx.doi.org/10.3390/v11010054.

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Staphylococcus aureus is one of the notable human pathogens that can be easily encountered in both dietary and clinical surroundings. Among various countermeasures, bacteriophage therapy is recognized as an alternative method for resolving the issue of antibiotic resistance. In the current study, bacteriophage CSA13 was isolated from a chicken, and subsequently, its morphology, physiology, and genomics were characterized. This Podoviridae phage displayed an extended host inhibition effect of up to 23 hours of persistence. Its broad host spectrum included methicillin susceptible S. aureus (MSSA

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Gautam, Bikram, Lomas Aryal, Sachana Adhikari, Manoj Rana, Anjita Rajbhanshi, Sunita Ghale, and Rameshwar Adhikari. "Isolation of Bacteriophage from Guheswori Sewage Treatment Plant Capable of Infecting Pathogens." Research in Pharmacy and Health Sciences 4, no. 2 (May 15, 2018): 465–70. http://dx.doi.org/10.32463/rphs.2018.v04i02.11.

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Background: Waste water contains microorganisms which are continuously shed in the feces. These microorganisms especially bacteria might acquire antibiotic resistance and pose a significant threat to human health. Therefore, this work aims at isolating bacteriophage capable of infecting the isolated bacteria. Methodology: For this purpose, the grab sampling was performed at the Guheswori sewage treatment plant from the inlet in the primary treatment plant and from the outlet of the secondary treatment plant. For the isolation of bacteriophage, bacteriophage in the sewage was first enriched in

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Gordina, Ekaterina M., Svetlana A. Bozhkova, and L. N. Smirnova. "Effects of bacteriophages on biofilms formed by Staphylococcus aureus isolated from patients with orthopedic infection." Clinical Microbiology and Antimicrobial Chemotherapy 24, no. 3 (2022): 283–88. http://dx.doi.org/10.36488/cmac.2022.3.283-288.

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Objective. To study effects of bacteriophages on biofilm formation and formed biofilm by S. aureus isolated from patients with orthopedic infection. Materials and Methods. A total of 50 clinical strains of S. aureus were tested. Species identification was performed by MALDI-TOF MS, antibiotic susceptibility – in accordance with the EUCAST v21. Isolates susceptibility to bacteriophages «Sextafag» (Microgen, Russia) was determined by MPA medium. The antibacterial activity of phages against S. aureus ATCC 29213 and S. aureus ATCC 43300 was evaluated by growth kinetic curves. Biofilms of bacteriop

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Oduor, Joseph Michael Ochieng', Nyamongo Onkoba, Fredrick Maloba, Washingtone Ouma Arodi, and Atunga Nyachieo. "Efficacy of lytic Staphylococcus aureus bacteriophage against multidrug-resistant Staphylococcus aureus in mice." Journal of Infection in Developing Countries 10, no. 11 (November 24, 2016): 1208–13. http://dx.doi.org/10.3855/jidc.7931.

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Introduction: The use of bacteriophages as an alternative treatment method against multidrug-resistant bacteria has not been explored in Kenya. This study sought to determine the efficacy of environmentally obtained lytic bacteriophage against multidrug-resistant Staphylococcus aureus (MDRSA) bacterium in mice. Methodology: Staphylococcus aureus bacterium and S. aureus-specific lytic phage were isolated from sewage and wastewater collected within Nairobi County, Kenya. Thirty mice were randomly assigned into three groups: MDRSA infection group (n = 20), phage-infection group (n = 5), and non-i

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Imanishi, Ichiro, Jumpei Uchiyama, Toshihiro Tsukui, Junzo Hisatsune, Kaori Ide, Shigenobu Matsuzaki, Motoyuki Sugai, and Koji Nishifuji. "Therapeutic Potential of an Endolysin Derived from Kayvirus S25-3 for Staphylococcal Impetigo." Viruses 11, no. 9 (August 22, 2019): 769. http://dx.doi.org/10.3390/v11090769.

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Impetigo is a contagious skin infection predominantly caused by Staphylococcus aureus. Decontamination of S. aureus from the skin is becoming more difficult because of the emergence of antibiotic-resistant strains. Bacteriophage endolysins are less likely to invoke resistance and can eliminate the target bacteria without disturbance of the normal microflora. In this study, we investigated the therapeutic potential of a recombinant endolysin derived from kayvirus S25-3 against staphylococcal impetigo in an experimental setting. First, the recombinant S25-3 endolysin required an incubation perio

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Horiuk, Y. "Determination of the drug Fagomast effectiveness with different titers of Phage SAvB14." Naukovij vìsnik veterinarnoï medicini, no. 2 (168) (December 9, 2021): 57–64. http://dx.doi.org/10.33245/2310-4902-2021-168-2-57-64.

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Treatment of bacterial infections with bacteriophages is one of the alternative methods. However, the use of freely dispersed bacteriophages for treatment causes their inactivation under physiological conditions. Therefore, it is important to consider the concentration of bacteriophages in phage therapy. The aim of study – to determine the optimal titer of bacteriophage Phage SAvB14 in the drug Fagomast for the effective treatment of subclinical mastitis in cows caused by Stapholococcus aureus var. bovis. For research to determine the optimal therapeutic dose of the bacteriophage drug Fagomast

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Aslanov, B. I., A. V. Lubimova, and L. P. Zueva. "BACTERIOPHAGES AS EFFECTIVE ANTIEPIDEMIC AGENTS FOR CONTROL OF HOSPITAL-ACQUIRED INFECTION OUTBREAKS." Journal Infectology 11, no. 1 (March 30, 2019): 65–70. http://dx.doi.org/10.22625/2072-6732-2019-11-1-65-70.

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Antibiotic resistance threatens the effective prevention and treatment of healthcare associated infections which are the most frequent adverse event in health-care settings worldwide. There is an urgent need to investigate alterative preventive and treatment options while there are still a few antibiotics left. Bacteriophage (phage) therapy has been championed as a promising alternative to antibiotics.The aim of this study was to evaluate the efficacy of a therapeutic bacteriophages to control of Staphylococcus aureus and Klebsiella pneumonia outbreaks in newborn intensive care units.Materials

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Voronkova, Olga S., and Albert I. Vinnikov. "Fahotyp and Sensitivity to Medications Phage Film-Forming Strains Staphylococcus aureus, Isolated from Respiratory Tract." International Letters of Natural Sciences 51 (February 2016): 1–5. http://dx.doi.org/10.18052/www.scipress.com/ilns.51.1.

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The study of biological properties of filmforming Staphylococcus aureus strains, including its sensitivity to bacteriophages, is one of the important tasks of laboratory diagnostic service that allows, if it necessary, choose an alternative treatment strategy and to establish the sources of strains. In the study of material from the nose and throat of 26 persons-volunteers the strains of S. aureus were selected. Among them 16 (61.5%) were able to form biofilms. Analysis of resistance to phages drugs of filmformation strains of S. aureus showed that 87.5% strains were sensitive the phages drugs

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Voronkova, Olga S., and Albert I. Vinnikov. "Fahotyp and Sensitivity to Medications Phage Film-Forming Strains <i>Staphylococcus aureus</i>, Isolated from Respiratory Tract." International Letters of Natural Sciences 51 (February 9, 2016): 1–5. http://dx.doi.org/10.56431/p-15g9r4.

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The study of biological properties of filmforming Staphylococcus aureus strains, including its sensitivity to bacteriophages, is one of the important tasks of laboratory diagnostic service that allows, if it necessary, choose an alternative treatment strategy and to establish the sources of strains. In the study of material from the nose and throat of 26 persons-volunteers the strains of S. aureus were selected. Among them 16 (61.5%) were able to form biofilms. Analysis of resistance to phages drugs of filmformation strains of S. aureus showed that 87.5% strains were sensitive the phages drugs

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Григорова, Екатерина, Ekaterina Grigorova, Наталья Воропаева, Natalya Voropayeva, Ульяна Немченко, Ulyana Nemchenko, Елена Иванова, et al. "RESPONSE SENSITIVITY TO BACTERIOPHAGES OF STAPHYLOCOCCUS AUREUS STRAINS ISOLATED FROM THE MICROBIOTA OF THE OROPHARYNX IN CHILDREN OF IRKUTSK." Acta biomedica scientifica 2, no. 5 (January 18, 2018): 65–69. http://dx.doi.org/10.12737/article_5a3a0dbfab5dc2.42779093.

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Dysbiotic disorders of the oropharynx takes one of the first places in the structure of morbidity worldwide. The aim of the study was to determine the peculiarities of microbiocenosis of the oropharynx in children at different ages and to assess the level of sensitivity of S. aureus strains to specific bacteriophages. Material for the study consisted of 84 smears from the oropharynx of children with inflammatory diseases of the upper respiratory tract (nasopharyngi- tis, pharyngitis, tonsillitis, laryngitis (J00, J02, J03, J04 according to ICD-10). The biological materi

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O'Flaherty, S., R. P. Ross, W. Meaney, G. F. Fitzgerald, M. F. Elbreki, and A. Coffey. "Potential of the Polyvalent Anti-Staphylococcus Bacteriophage K for Control of Antibiotic-Resistant Staphylococci from Hospitals." Applied and Environmental Microbiology 71, no. 4 (April 2005): 1836–42. http://dx.doi.org/10.1128/aem.71.4.1836-1842.2005.

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ABSTRACT The increasing prevalence of antibiotic-resistant staphylococci has prompted the need for antibacterial controls other than antibiotics. In this study, a lytic bacteriophage (phage K) was assessed in vitro for its ability to inhibit emerging drug-resistant Staphylococcus aureus strains from hospitals and other species of Staphylococcus isolated from bovine infections. In in vitro inhibitory assays, phage K lysed a range of clinically isolated methicillin-resistant S. aureus (MRSA) strains, S. aureus with heterogeneous vancomycin resistance and vancomycin resistance, and teicoplanin-re

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Kitamura, Naoya, Eri Sasabe, Shigenobu Matsuzaki, Masanori Daibata, and Tetsuya Yamamoto. "Characterization of two newly isolated Staphylococcus aureus bacteriophages from Japan belonging to the genus Silviavirus." Archives of Virology 165, no. 10 (August 3, 2020): 2355–59. http://dx.doi.org/10.1007/s00705-020-04749-6.

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Abstract Two Staphylococcus aureus bacteriophages, KSAP7 and KSAP11, were isolated from sewage and characterized. Based on morphology and DNA sequences, they were assigned to the genus Silviavirus, subfamily Twortvirinae, family Herelleviridae, whose members are hypothesized to be suitable for bacteriophage therapy. The KSAP7 and KSAP11 genomes were 137,950 and 138,307 bp in size, respectively. Although their DNA sequences were almost identical, evidence of site-specific DNA rearrangements was found in two regions. Changes in the number of PIEPEK amino acid sequence repeats encoded by orf10 an

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Speck, Peter G., Morgyn S. Warner, Shailesh Bihari, Andrew D. Bersten, James G. Mitchell, Joseph Tucci, and David L. Gordon. "Potential for bacteriophage therapy for Staphylococcus aureus pneumonia with influenza A coinfection." Future Microbiology 16, no. 3 (February 2021): 175–84. http://dx.doi.org/10.2217/fmb-2020-0163.

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The ability of influenza A virus to evolve, coupled with increasing antimicrobial resistance, could trigger an influenza pandemic with great morbidity and mortality. Much of the 1918 influenza pandemic mortality was likely due to bacterial coinfection, including Staphylococcus aureus pneumonia. S. aureus resists many antibiotics. The lack of new antibiotics suggests alternative antimicrobials, such as bacteriophages, are needed. Potential delivery routes for bacteriophage therapy (BT) include inhalation and intravenous injection. BT has recently been used successfully in compassionate access p

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Pertics, Botond Zsombor, Dalma Szénásy, Dániel Dunai, Yannick Born, Lars Fieseler, Tamás Kovács, and György Schneider. "Isolation of a Novel Lytic Bacteriophage against a Nosocomial Methicillin-Resistant Staphylococcus aureus Belonging to ST45." BioMed Research International 2020 (December 22, 2020): 1–10. http://dx.doi.org/10.1155/2020/5463801.

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Methicillin-resistant Staphylococcus aureus (MRSA) can cause a wide range of infections from mild to life-threatening conditions. Its enhanced antibiotic resistance often leads to therapeutic failures and therefore alternative eradication methods must be considered. Potential candidates to control MRSA infections are bacteriophages and their lytic enzymes, lysins. In this study, we isolated a bacteriophage against a nosocomial MRSA strain belonging to the ST45 epidemiologic group. The phage belonging to Caudovirales, Siphoviridae, showed a narrow host range and stable lytic activity without th

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González-Menéndez, Eva, Lucía Fernández, Diana Gutiérrez, Daniel Pando, Beatriz Martínez, Ana Rodríguez, and Pilar García. "Strategies to Encapsulate the Staphylococcus aureus Bacteriophage phiIPLA-RODI." Viruses 10, no. 9 (September 13, 2018): 495. http://dx.doi.org/10.3390/v10090495.

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The antimicrobial properties of bacteriophages make them suitable food biopreservatives. However, such applications require the development of strategies that ensure stability of the phage particles during food processing. In this study, we assess the protective effect of encapsulation of the Staphylococcus aureus bacteriophage phiIPLA-RODI in three kinds of nanovesicles (niosomes, liposomes, and transfersomes). All these systems allowed the successful encapsulation of phage phiIPLA-RODI with an efficiency ranged between 62% and 98%, regardless of the concentration of components (like phosphol

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Wills, Quintin F., Claire Kerrigan, and James S. Soothill. "Experimental Bacteriophage Protection against Staphylococcus aureus Abscesses in a Rabbit Model." Antimicrobial Agents and Chemotherapy 49, no. 3 (March 2005): 1220–21. http://dx.doi.org/10.1128/aac.49.3.1220-1221.2005.

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ABSTRACT In a rabbit model of wound infection caused by Staphylococcus aureus, 2 × 109 PFU of staphylococcal phage prevented abscess formation in rabbits when it was injected simultaneously with S. aureus (8 × 107 CFU) into the same subcutaneous site. Phage multiplied in the tissues. Phages might be a valuable prophylaxis against staphylococcal infection.

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Fenton, Mark, Ruth Keary, Olivia McAuliffe, R. Paul Ross, Jim O'Mahony, and Aidan Coffey. "Bacteriophage-Derived PeptidaseCHAPKEliminates and Prevents Staphylococcal Biofilms." International Journal of Microbiology 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/625341.

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New antibacterial agents are urgently needed for the elimination of biofilm-forming bacteria that are highly resistant to traditional antimicrobial agents. Proliferation of such bacteria can lead to significant economic losses in the agri-food sector. This study demonstrates the potential of the bacteriophage-derived peptidase,CHAPK, as a biocidal agent for the rapid disruption of biofilm-forming staphylococci, commonly associated with bovine mastitis. PurifiedCHAPKapplied to biofilms ofStaphylococcus aureusDPC5246 completely eliminated the staphylococcal biofilms within 4 h. In addition,CHAPK

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Venezia, Richard A., Michael Orrico, Edward Houston, Shu-Min Yin, and Yelena Y. Naumova. "Lethal Activity of Nonthermal Plasma Sterilization Against Microorganisms." Infection Control & Hospital Epidemiology 29, no. 5 (May 2008): 430–36. http://dx.doi.org/10.1086/588003.

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Objective.To determine the range and the mode of germicidal activity of sterilants generated by a nonthermal plasma sterilization system for microorganisms.Methods.Representative bacteria, spores, viruses, bacteriophages, and fungi were exposed to the plasma cycle and the residual viability was measured in vitro. To assess the mode of lethal injury,Escherichia coli, Staphylococcus aureus, Bacillus atrophaeus,and bacteriophages were exposed to the plasma cycle, and the effects of the plasma-generated sterilants on the biological parameters were determined.Results.There were at least 4-6 log red

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Zhandalgarova, Adelya Dzumaniyashevna, Anna Aleksandrovna Bakhareva, Yulia Nikolaevna Grozesku, and Aleksandr Nevalennyy. "Study of microbiocenosis of fish gills and intestines in their cultivation using preparations based on bacteriophages." Vestnik of Astrakhan State Technical University. Series: Fishing industry, no. 4 (December 30, 2021): 126–33. http://dx.doi.org/10.24143/2073-5529-2021-4-126-133.

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Nowadays bacteriophages are widely used in veterinary medicine, bio-technology, agriculture and in particular in aquaculture. Narrow specificity affecting the bacterial microflora and selective influence on the pathogenic and opportunistic microorganisms allow using the bacteriophages for diagnosing, preventing and treating the diseases of farm animals and fish. The emergence of antibiotic-resistant strains of microorganisms involves the search for new drugs to combat them. In this regard, phage therapy is an alternative to antimicrobial treatment of bacterial diseases of animals and fish. Des

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Horiuk, Y. V., M. D. Kukhtyn, V. V. Horiuk, V. A. Sytnik, and O. O. Dashkovskyy. "Effect of Phage SAvB14 combined with antibiotics on Staphylococcus aureus variant bovis." Regulatory Mechanisms in Biosystems 12, no. 3 (September 3, 2021): 531–36. http://dx.doi.org/10.15421/022173.

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Because using antimicrobial drugs leads to development of resistance among bacterial isolates, the treatment with antimicrobial drugs in human and veterinary medicine in general should be reduced. Currently, therapeutic use of bacteriophages may be an alternative or addition to the treatment of bacterial infections of animals. The article presents the results of studying the effect of bacteriophage Phage SAvB14 on microbial biofilms of Staphylococcus aureus variant bovis both alone and in complex with antibiotics. For this purpose, we used strain S. aureus var. bovis 1491 f and bacteriophage P

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Horiuk, Yu V. "Characterization of the biological properties of bacteriophages Staphylococcus aureus variant bovis." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, no. 96 (December 14, 2019): 47–52. http://dx.doi.org/10.32718/nvlvet9608.

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Cattle mastitis is the main cause of economic losses in milk production worldwide, and Staphylococcus aureus is the pathogen that causes it most. Bacteriophages may be an alternative treatment for this disease. In this study, we studied the effect of temperature and pH on the lytic activity of bacteriophages isolated from cows with signs of mastitis. The isolation and production of pure phage lines were performed on an indicator culture of Staphylococcus aureus var. bovis 1491f conventional methods. The following phages were isolated and labeled: Phage SAvB07, Phage SAvB08, Phage SAvB12, Phage

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Das, Avijit, Sukhendu Mandal, Vijay Hemmadi, Vivek Ratre, and Malabika Biswas. "Studies on the gene regulation involved in the lytic–lysogenic switch in Staphylococcus aureus temperate bacteriophage Phi11." Journal of Biochemistry 168, no. 6 (July 23, 2020): 659–68. http://dx.doi.org/10.1093/jb/mvaa080.

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Abstract Antirepressor proteins of bacteriophages are chiefly involved in interfering with the function of the repressor protein and forcing the bacteriophage to adopt the lytic cycle. The genome of Staphylococcus aureus phage, Phi11 has already been sequenced; from the genome sequence, we amplified gp07 gene and analysed its involvement in the developmental pathway of Phi11. Our results indicate that Gp07 functions as a novel antirepressor and regulates the developmental pathway of Phi11 by enhancing the binding of the Cro repressor protein to its cognate operator. We also report our finding

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Abril, Ana G., Mónica Carrera, Karola Böhme, Jorge Barros-Velázquez, Benito Cañas, José-Luis R. Rama, Tomás G. Villa, and Pilar Calo-Mata. "Proteomic Characterization of Bacteriophage Peptides from the Mastitis Producer Staphylococcus aureus by LC-ESI-MS/MS and the Bacteriophage Phylogenomic Analysis." Foods 10, no. 4 (April 8, 2021): 799. http://dx.doi.org/10.3390/foods10040799.

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The present work describes LC-ESI-MS/MS MS (liquid chromatography-electrospray ionization-tandem mass spectrometry) analyses of tryptic digestion peptides from phages that infect mastitis-causing Staphylococcus aureus isolated from dairy products. A total of 1933 nonredundant peptides belonging to 1282 proteins were identified and analyzed. Among them, 79 staphylococcal peptides from phages were confirmed. These peptides belong to proteins such as phage repressors, structural phage proteins, uncharacterized phage proteins and complement inhibitors. Moreover, eighteen of the phage origin peptid

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Turdieva, Sh T., G. R. Nasirova, and D. K. Ganiyeva. "Possibilities of inhalation bacteriophage therapy in treatment of children with acute tonsillitis." Meditsinskiy sovet = Medical Council, no. 17 (November 1, 2021): 86–93. http://dx.doi.org/10.21518/2079-701x-2021-17-86-93.

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Introduction. At the same time, in the last decade, pediatricians have increased interest in the study of the therapeutic effect of bacteriophages in infectious diseases of rhinolaryngological organs.Objective. The analysis of results of the use of inhalation bacteriophage therapy in children with acute tonsillitis, on an outpatient basis.Materials and methods. Examined 212 children from 4 to 15 years old with acute tonsillitis. Conducted general clinical research, pharyngoscopy, bacteriological examination of a smear of tonsils. Bacteriophage therapy carried out using the Pyobacteriophage com

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Pacífico, Hilbert, Sofka, Dinhopl, Pap, Aspöck, and Hilbert. "Characterization of Bacteria and Inducible Phages in an Intensive Care Unit." Journal of Clinical Medicine 8, no. 9 (September 10, 2019): 1433. http://dx.doi.org/10.3390/jcm8091433.

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Intensive care units (ICUs) are critical locations for the transmission of pathogenic and opportunistic microorganisms. Bacteria may develop a synergistic relationship with bacteriophages and more effectively resist various stresses, enabling them to persist despite disinfection and antimicrobial treatment. We collected 77 environmental samples from the surroundings of 12 patients with infection/colonizations by Escherichia coli, Staphylococcus aureus or Klebsiella spp in an ICU in Austria. Surface swabs were tested for lytic phages and bacterial isolates for mitomycin C-inducible prophages. N

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