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Journal articles on the topic 'Baffa'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Hazib Ali, Eman Fatima, Abdul Qadir Kumbhar, et al. "Effect of Different Urea Doses on the Performance of Wheat Under the Agro-Climatic Conditions of Mansehra, Khyber Pakhtunkhwa, Pakistan." Indus Journal of Bioscience Research 2, no. 2 (2024): 1083–90. https://doi.org/10.70749/ijbr.v2i02.334.

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The research conducted aimed to evaluate the impact of varying urea doses on the performance of wheat (Triticum aestivum), with a focus on growth, yield, and nitrogen use efficiency. Urea, a common nitrogen fertilizer, is crucial in enhancing crop productivity. The experiment was conducted in 2022-2023 at the Agriculture Research Station Baffa Mansehra in Khyber Pakhtunkhwa, Pakistan. The research material consisted of a Wheat variety. The Seeds were sown in RCBD design on 15th October 2022 at an Agriculture Research Station Baffa Mansehra. The experiment used a randomized complete block desig

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2

Neves, Walter, Alex Hubbe, and Ivo Karmann. "New Accelerator Mass Spectrometry (AMS) Ages Suggest a Revision of the Electron Spin Resonance (ESR) Middle Holocene Dates Obtained for a Toxodon platensis (Toxodontidae, Mammalia) from Southeast Brazil." Radiocarbon 49, no. 3 (2007): 1411–12. http://dx.doi.org/10.1017/s003382220004323x.

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In a paper published in Applied Radiation and Isotopes, Baffa et al. (2000) reported a Middle Holocene date (∼6.5 kyr BP) for a specimen of Toxodon platensis from Ribeira do Iguape, southeast Brazil, using the emergent technique electron spin resonance (ESR). Through an accelerator mass spectrometry (AMS) procedure applied on tooth collagen, we provide a new set of dates to test the accuracy of the ages generated by ESR. We obtained 2 dates more than 4500 BP older than the previous one, suggesting a minimum Late Pleistocene age for the specimen.

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Ullah, Irfan, Azhar Shah, Zahid Khan, et al. "Phenotypic Diversity and Pest Management of Potato Varieties Grown at Baffa Mansehra." Polish Journal of Environmental Studies 29, no. 3 (2020): 2373–81. http://dx.doi.org/10.15244/pjoes/111577.

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Ahmed, Naveed, Muhammad Razaq, Hasnain Alam, and Salahuddin. "Response of French Bean Cultivars to Plant Spacing Under Agroclimatic Condition of Baffa." Journal of Northeast Agricultural University (English Edition) 23, no. 1 (2016): 16–19. http://dx.doi.org/10.1016/s1006-8104(16)30027-7.

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5

Lin, Wai, Joanne Hildebrand, and Gail Bishop. "New insights into TRAF-mediated regulation of BAFF receptor signals (P1110)." Journal of Immunology 190, no. 1_Supplement (2013): 64.2. http://dx.doi.org/10.4049/jimmunol.190.supp.64.2.

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Abstract BAFF receptor (BAFFR), a member of the TNFR superfamily, binds to the pro-survival cytokine BAFF to promote B cell development and survival, and deficiencies of either BAFFR or BAFF result in inhibition of B cell development. BAFF-R engagement recruits TRAFs 2, 3 and 6 and activates the non-canonical NF-κB2 pathway. Current models propose that TRAF3 mediates degradation of the NF-κB activating kinase NIK, concluding that BAFFR-mediated TRAF3 degradation is necessary and sufficient for NF-κB2 activation. However, our recent studies of a mutant BAFFR indicate that this model is inadequa

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Junaid, Muhammad, Azmat Kamran, Suriyakala Perumal chandran, and Muhammad Junaid. "AGE-RELATED EFFECTS OF DONOR ON CORNEAL TRANSPLANTATION AND CLINICAL STUDY OF CASUAL ALLOGRAFT REJECTION IN PAKISTAN." INSIGHTS-JOURNAL OF HEALTH AND REHABILITATION 03, no. 01 (2025): 353–60. https://doi.org/10.71000/wypqka87.

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Abstract <strong>Background: </strong>Corneal transplantation is a widely used procedure to restore vision in patients with corneal blindness. Donor age is considered a critical factor influencing graft survival, visual acuity, and allograft rejection. However, the impact of donor age on corneal transplantation outcomes remains a subject of debate. This study aims to evaluate the effects of donor age on graft clarity, visual outcomes, and rejection rates in a Pakistani population, addressing gaps in regional transplantation practices and guiding future donor selection criteria. <strong>Ob

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Krejsek, Jan, Martina Koláčková, Irena Lindrová, Radovan Slezák, and Ctirad Andrýs. "Increase of Intracellular BAFF in B Cells of Sjögren’s Patients Is Not Affected by Decrease of BAFFR." Acta Medica (Hradec Kralove, Czech Republic) 58, no. 1 (2015): 25–31. http://dx.doi.org/10.14712/18059694.2015.88.

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The presence of a broad spectrum of autoantibodies in Sjögren’s syndrome (SjS) patients is the result of abnormal B-cell regulation that can be at least partially explained by abnormal BAFF/BAFFR regulation. The objective of this study was to determine both membrane and intracellular expression of BAFF/BAFFR in monocytes and B-cells in peripheral blood of 19 primary Sjögren’s syndrome patients and 20 healthy controls using flow cytometry. We also measured sBAFF in serum. Compared to healthy controls, both surface and intracellular expression of BAFF was significantly increased in monocytes and

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Xu, Haifeng C., Jun Huang, Vishal Khairnar, et al. "Deficiency of the B Cell-Activating Factor Receptor Results in Limited CD169+Macrophage Function during Viral Infection." Journal of Virology 89, no. 9 (2015): 4748–59. http://dx.doi.org/10.1128/jvi.02976-14.

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ABSTRACTThe B cell-activating factor (BAFF) is critical for B cell development and humoral immunity in mice and humans. While the role of BAFF in B cells has been widely described, its role in innate immunity remains unknown. Using BAFF receptor (BAFFR)-deficient mice, we characterized BAFFR-related innate and adaptive immune functions following infection with vesicular stomatitis virus (VSV) and lymphocytic choriomeningitis virus (LCMV). We identified a critical role for BAFFR signaling in the generation and maintenance of the CD169+macrophage compartment. Consequently,Baffr−/−mice exhibited

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9

Testi, L., A. Natta, C. Baffa, et al. "An Efficient Low-Resolution NIR Classification Scheme for M, L, and T dwarfs and Its Application to Young BDs." Symposium - International Astronomical Union 211 (2003): 359–60. http://dx.doi.org/10.1017/s0074180900210917.

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We present the preliminary results of a programme aimed at defining a low-resolution near-infrared spectral classification scheme for faint M, L, and T-dwarfs. The method is based on the global shape of R˜100 complete near-infrared spectra from 0.8 to 2.4μm as obtained through a high-throughput prism-based optical element, the Amici device, mounted inside the NICS instrument at the TNG 3.5m telescope (Baffa et al. 2001; Oliva 2000). The aim of our project is to provide an efficient classification scheme based on very low-resolution near infrared spectroscopy, which can be carried on at a 4m-cl

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Prieto-Peña, D., F. Genre, S. Remuzgo Martinez, et al. "AB0146 BAFF, APRIL y BAFFR: DIFFERENTIAL BIOMARKERS BETWEEN IgA VASCULITIS AND IgA NEPHROPATHY?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1203–4. http://dx.doi.org/10.1136/annrheumdis-2022-eular.425.

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BackgroundIgA vasculitis (IgAV) and IgA nephropathy (IgAN) are inflammatory conditions [1, 2], that share pathogenic mechanisms [1], in which B-lymphocytes are described as key cells implicated in these processes. BAFF, APRIL and BAFF-R are cytokines implicated in the development of B-lymphocytes [3, 4] and in autoimmune processes [5, 6]. In this regard, an influence of BAFF, APRIL and BAFFR polymorphisms was observed on several immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion variant for inflammatory conditions [7, 8].ObjectivesTo determine whether BAFF, APRIL and

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Prieto-Peña, D., S. Remuzgo Martinez, F. Genre, et al. "POS0113 BAFF-APRIL-BAFFR PATHWAY ON THE PATHOGENESIS OF IMMUNOGLOBULIN-A VASCULITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 267.2–268. http://dx.doi.org/10.1136/annrheumdis-2021-eular.707.

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Background:BAFF, APRIL and BAFFR are genes that encode cytokines with a key role in the development and survival of B-lymphocytes [1-4]: The B cell-activating factor (BAFF, also known as BLyS), a proliferation-inducing ligand (APRIL) and BAFF receptor (BAFF-R), respectively. Previous genetic studies have revealed that the BAFF-APRIL-BAFFR pathway is implicated in the genetic predisposition to several immune-mediated diseases [5].Objectives:To determine whether the BAFF-APRIL-BAFFR pathway represents a novel genetic risk factor for the pathogenesis of Immunoglobulin-A vasculitis (IgAV), an infl

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Hildebrand, Joanne, and Gail Bishop. "TRAF6, a new member of the proximal signaling complex recruited by BAFFR and TACI in B lymphocytes (34.1)." Journal of Immunology 184, no. 1_Supplement (2010): 34.1. http://dx.doi.org/10.4049/jimmunol.184.supp.34.1.

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Abstract The cytokines BAFF (B-cell activating factor of the TNF family, BLyS) and APRIL (a proliferation-inducing ligand) activate several major signaling cascades responsible for B-cell survival and homeostasis. Made primarily by myeloid cells, BAFF binds and activates three cell membrane receptors; BCMA (B-cell maturation antigen), TACI (transmembrane activator and CAML interactor), and BAFF-R (BAFF Receptor, BR3), while APRIL binds TACI and BCMA. Studies of genetically altered mice demonstrate that TACI and BCMA perform niche roles in B-cell Ig isotype switching and plasma cell maintenance

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Syed, Husnain Ali Shah. "Influence of Granite Cutting Waste Addition on the Geotechnical Parameters of Cohesive Soil." International Journal of Engineering Research and Advanced Technology (IJERAT) 5, no. 7 (2019): 75–84. https://doi.org/10.31695/IJERAT.2019.3459.

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<em>The current study analyzes the effect of granite cutting waste addition on the properties of cohesive soil. Representative samples of cohesive soils were collected from the Mansehra and Balakot areas of Hazara, Pakistan and their major geotechnical properties determined following the standard ASTM procedures. The determined properties include the Atterberg limits, i.e. Liquid Limit (LL), Plastic Limit (PL), Plasticity Index (PI), and Maximum dry density, Optimum moisture contents, Un-confined compressive strength, Activity and Expansion. Both the soils are classified as active soils posses

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Dickinson, Gregory S., Guizhi Sun, Richard J. Bram, and Kishore R. Alugupalli. "Efficient B Cell Responses to Borrelia hermsii Infection Depend on BAFF and BAFFR but Not TACI." Infection and Immunity 82, no. 1 (2013): 453–59. http://dx.doi.org/10.1128/iai.01147-13.

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ABSTRACTT cell-independent antibody responses develop rapidly, within 3 to 4 days, and are critical for preventing blood-borne pathogens from evolving into life-threatening infections. The interaction of BAFF, also known as BLyS, with its receptors BAFFR and TACI on B cells is critical for B cell homeostasis and function. Using a synthetic polysaccharide antigen, it has previously been shown that TACI is critical for T cell-independent antibody responses. To examine the role of BAFFR and TACI in T cell-independent antibody responses to an active infection, we utilized theBorrelia hermsiiinfect

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Hill, Thomas, Anthony Redmond, and Helen Dooley. "Investigating the functional roles of TNFSF13 family members in Cartilaginous Fishes." Journal of Immunology 210, no. 1_Supplement (2023): 224.03. http://dx.doi.org/10.4049/jimmunol.210.supp.224.03.

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Abstract The TNFSF13 cytokines BAFF and APRIL along with their cognate receptors BAFFR, TACI, and BCMA play critical parts in the development, function, and maintenance of B cells in mammals. Despite the well-studied roles that BAFF and APRIL play in the immune systems of higher vertebrates, their evolutionary history and functions in non-mammalian organisms are not well understood. Recently, our lab has demonstrated that collectively the TNFSF is evolutionarily ancient, with most of its members having evolved over 450 million years ago in the jawed vertebrate ancestor. Interestingly, we found

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Neys, Stefan F. H., Gwenny M. Verstappen, Hendrika Bootsma, Frans G. M. Kroese, Rudi W. Hendriks, and Odilia B. J. Corneth. "Decreased BAFF Receptor Expression and Unaltered B Cell Receptor Signaling in Circulating B Cells from Primary Sjögren’s Syndrome Patients at Diagnosis." International Journal of Molecular Sciences 23, no. 9 (2022): 5101. http://dx.doi.org/10.3390/ijms23095101.

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Animal models of autoimmunity and human genetic association studies indicate that the dysregulation of B-cell receptor (BCR) signaling is an important driver of autoimmunity. We previously showed that in circulating B cells from primary Sjögren’s syndrome (pSS) patients with high systemic disease activity, protein expression of the BCR signaling molecule Bruton’s tyrosine kinase (BTK) was increased and correlated with T-cell infiltration in the target organ. We hypothesized that these alterations could be driven by increased B-cell activating factor (BAFF) levels in pSS. Here, we investigated

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Shah, Syed Ihsan Ullah, Naushad Ali, Hassan Mujtaba, et al. "Genetic Diversity and Heritability Studies for Yield and Yield Related Attributes in Wheat (Triticum aestivum L.)." Planta Animalia 3, no. 2 (2024): 67–75. https://doi.org/10.71454/pa.003.02.0041.

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Evaluation and identification of superior genotypes for general cultivation is considered as crucial concern for any successful breeding scheme. This field experiment was performed at agriculture research station Baffa Mansehra to check variability among different wheat varieties during 2020. Thirty-six wheat varieties along with 2 check cultivar were sown in randomized complete block design (RCB) in two replications. Data recorded for days to emergence, days to heading, days to maturity, plant height, tillers m-2, length of spike, 1000-grain weight, biological yield plot-1 and grain yield plo

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Zhu, Pengpeng, Guoteng Ou, Ting Zhou, et al. "The Polysaccharide from Dendrobium officinale Can Improve Mice with Sjögren’s Syndrome by Regulating BAFF and Fas Expressions." Journal of Food Biochemistry 2023 (December 28, 2023): 1–14. http://dx.doi.org/10.1155/2023/4733651.

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Exploring herbs and their compounds for potential drugs is a significant research focus due to the incurable nature of Sjögren’s syndrome (SS), a prevalent chronic inflammatory autoimmune disease. Dendrobium officinale polysaccharide (DOP) has demonstrated diverse biological effects, particularly in immunomodulation. Nonetheless, limited research has been conducted on DOP concerning the treatment of SS. This research aims to examine the impacts of DOP on experimental SS (ESS) mice and its possible mechanisms. An ESS animal model was established using the immune induction method. Besides the co

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Gribbin, Caitlin, Dylan McNally, Ioannis Karagiannidis, et al. "Follicular Dendritic Cells Represent a Therapeutic Vulnerability in Early Follicular Lymphoma." Blood 144, Supplement 1 (2024): 739. https://doi.org/10.1182/blood-2024-198542.

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Follicular lymphomas (FLs) arise from germinal center (GC) B cells and contain a rich tumor microenvironment (TME) including CD4+ and CD8+ T cells, macrophages, and lymphoid stromal cells, among which follicular dendritic cells (FDCs) are particularly abundant. FDCs interact with GC B cells through antigen presentation, secretion of BAFF, which binds to BAFFR to induce trophic signals, and secretion of CXCL13, which draws B cells into GCs via CXCR5. While the role of FDCs in FL is not fully understood, BAFFR expression has been associated with worse outcomes in diffuse large B-cell lymphoma. W

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Luo, Min, Guangchao Li, Wen Ding, et al. "Use of BAFFR CAR-T to treat B cell leukemia/lymphoma and auto-immune diseases." Journal of Clinical Oncology 43, no. 16_suppl (2025): 6523. https://doi.org/10.1200/jco.2025.43.16_suppl.6523.

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6523 Background: BAFFR (B-cell Activating Factor Receptor) is a member of the tumor necrosis factor (TNF) receptor superfamily and is almost exclusively expressed on B cells. Meanwhile, BAFFR is found to be highly expressed on the surface of lymphoma cells. In addition, blocking the BAFF/BAFFR interaction can inhibit the maturation of B cells, which is beneficial for alleviating autoimmune diseases, such as psoriasis, inflammatory bowel disease, multiple sclerosis, and rheumatoid arthritis. These characteristics make BAFFR a promising target for B-cell malignancies and auto-immune diseases. It

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Alexaki, Vassilia-Ismini, Vassiliki Pelekanou, George Notas, et al. "B-Cell Maturation Antigen (BCMA) Activation Exerts Specific Proinflammatory Effects in Normal Human Keratinocytes and Is Preferentially Expressed in Inflammatory Skin Pathologies." Endocrinology 153, no. 2 (2012): 739–49. http://dx.doi.org/10.1210/en.2011-1504.

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TNFα is known to be expressed in human skin, regulating immune-related responses. Here we report that human normal skin keratinocytes express the members of the TNF superfamily members A proliferation-inducing ligand (APRIL; TNFSF13), B cell-activating factor (BAFF; TNFSF13B), and their receptors, B cell maturation antigen (BCMA; TNFRSF17) and transmembrane activator, calcium-modulator, and cyclophilin ligand interactor (TACI; TNFRSF13B), in a distinct spatial pattern. Our data show a differential expression of these molecules within epidermal layers and skin appendages, whereas the BAFF-speci

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Eman Fatima, Hazib Ali, Muhammad Faisal, et al. "Comparative Study of Commercial Bread Wheat Varieties and Advance Wheat Lines to Explore Superior Attributes for Variety Development and Future Breeding Guidelines." Indus Journal of Bioscience Research 2, no. 2 (2024): 815–21. https://doi.org/10.70749/ijbr.v2i02.280.

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Knowledge about the potential and performance of advance wheat lines and commercial bread wheat varieties are vital for implicit variety adaptation. Comparative study was designed to quantify the performance of advance wheat lines, sixteen commercial wheat varieties and fourteen advance wheat lines were tested in randomized complete block design with 3 replications at Agricultural Research Station Baffa, Mansehra during wheat growing season 2022-23. The study evaluated wheat advance lines yield and resistance against powdery mildew disease, as compared to commercial varieties for adaptability

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Lee, Sang-Ryul, Clifton Ramsdell, Suzanne McCray, Ramiro Diz та Stephen Clarke. "NF-κB inducing kinase as a key player in regulating autoreactive B cell maturation (P4048)". Journal of Immunology 190, № 1_Supplement (2013): 44.9. http://dx.doi.org/10.4049/jimmunol.190.supp.44.9.

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Abstract The regulation of autoreactive B cells is crucial in immune systems to prevent developing autoimmune diseases in human and animal models. A critical peripheral B cell tolerance mechanism is exclusion of autoreactive B cells from the mature repertoire due to a failure to compete with non-autoreactive B cells. B cell activation factor (Baff) is one of the most important factors to discriminate autoreactive and non-autoreactive B cells in periphery. Therefore, the level of Baff expression in vivo is significant, since excess Baff can override exclusion and lead to autoimmunity, and may c

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Saidoune, F., N. Charles, J. Chezel, et al. "AB0140 BAFF NEUTRALIZATION HAS JANUS-FACED EFFECT ON ATHEROSCLEROSIS ASSOCIATED WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1370.3–1370. http://dx.doi.org/10.1136/annrheumdis-2020-eular.988.

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Background:Cardiovascular diseases (CVD) are the leading cause of death in systemic lupus erythematosus (SLE). B cells play a key role in the pathogenesis of lupus and anti-BAFF therapy has been approved in SLE. Since mature B cells also promote atherosclerosis, BAFF neutralization is expected to have an atheroprotective effect in SLE.Objectives:The aim of our study was to test this hypothesis using a new mouse model with a mix susceptibility to lupus and atherosclerosis that received or not an anti-BAFF treatment, and in a cohort of SLE patients in whom we monitored carotid plaques, the B cel

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Del Real, Marissa Morales, John H. Baird, Lu Chen, et al. "Favorable Safety Profile and Durable Responses to Pmb-CT01 (BAFFR-CAR T Cell) Therapy in Patients with B-Cell Lymphomas Ineligible for or Who Failed CD19-Targeted Therapy, Including CD19-Negative Disease." Blood 144, Supplement 1 (2024): 3127. https://doi.org/10.1182/blood-2024-198416.

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Introduction: CD19-directed therapies have transformed the care of patients with B-cell malignancies, but many patients still relapse or have refractory disease. Relapse with CD19 loss as a mechanism of tumor escape is common and poses a significant challenge, particularly as these treatments move into earlier lines of therapy. Patients who are ineligible for or have failed prior CD19-targeted therapy have limited salvage options and a very poor prognosis, highlighting the urgent need to develop alternative approaches to improve the outcomes. We have developed CAR T cells against a new target,

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Li, Kai, Wei Yu, Rangjuan Cao, Zhihua Zhu, and Guoqing Zhao. "Microglia-mediated BAFF–BAFFR ligation promotes neuronal survival in brain ischemia injury." Neuroscience 363 (November 2017): 87–96. http://dx.doi.org/10.1016/j.neuroscience.2017.09.007.

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Lin, WeiYu, Qian Gong, Dhaya Seshasayee, et al. "Anti-BR3 antibodies – a new class of B cell immunotherapies combining cellular depletion and survival blockade (131.25)." Journal of Immunology 178, no. 1_Supplement (2007): S242. http://dx.doi.org/10.4049/jimmunol.178.supp.131.25.

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Abstract Pathogenic B lymphocytes removal through therapy with depleting monoclonal antibodies results in clinical benefit in both oncology and immunological indications. Incomplete rates of clinical response and the realization that B cell depletion following immunotherapy is incomplete fuels the need for better therapies. BAFF/BLyS signaling through its BAFFR/BR3 receptor have a critical role on B cell proliferation and survival in the mouse and to some extent in non-human primates and humans. In order to combine B cell depletion with the blockade of BAFF mediated B cell survival, we generat

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Pelekanou, Vassiliki, George Notas, Katerina Theodoropoulou, et al. "Detection of The TNFSF Members BAFF, APRIL, TWEAK and Their Receptors in Normal Kidney and Renal Cell Carcinomas." Analytical Cellular Pathology 34, no. 1-2 (2011): 49–60. http://dx.doi.org/10.1155/2011/108631.

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In advanced renal cell carcinoma (RCC), surgery combined with systemic chemotherapy and immunotherapy have had limited effectiveness. Therapeutic modalities targeting VEGF, PDGF, and c-kit using tyrosine kinase inhibitors and m-TOR using specific biologic factors are in development. Therapeutic approaches targeting TNF-alpha have shown limited efficacy, while anti-TRAIL (TNFSF10) antibodies have shown enhanced activity. The presence and potential significance of other members of the TNFSF has not been investigated. Here, we assayed the TNFSF members APRIL, BAFF, TWEAK and their receptors (BCMA

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Stunz, Laura L., Pradeep Bangalore-Prakash, Nurbek Mambetsariev, and Gail A. Bishop. "The lymphomagenic molecule LMP1 sequesters TRAF3 to induce enhanced B cell survival." Journal of Immunology 198, no. 1_Supplement (2017): 130.21. http://dx.doi.org/10.4049/jimmunol.198.supp.130.21.

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Abstract The human TRAF3 gene is frequently mutated in multiple myeloma and lymphoma. TRAF3 restrains homeostatic B cell survival. B cell TRAF3 deficiency promotes enhanced viability and over-expression of the anti-apoptotic molecules NIK, Mcl1 and Pim2, enhanced nuclear CREB, and increased pSTAT3 in response to IL6 signaling. We assessed TRAF3 protein expression in human lymphoma samples. The number of TRAF3low DLBCL was higher than predicted based on genetic loss, so we speculated that cellular TRAF3 can be depleted through other means. The oncogenic Epstein Barr virus protein LMP1 binds TRA

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Bojadzic, Damir, and Peter Buchwald. "Toward Small-Molecule Inhibition of Protein–Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions." Current Topics in Medicinal Chemistry 18, no. 8 (2018): 674–99. http://dx.doi.org/10.2174/1568026618666180531092503.

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Protein-Protein Interactions (PPIs) that are part of the costimulatory and coinhibitory (immune checkpoint) signaling are critical for adequate T cell response and are important therapeutic targets for immunomodulation. Biologics targeting them have already achieved considerable clinical success in the treatment of autoimmune diseases or transplant recipients (e.g., abatacept, belatacept, and belimumab) as well as cancer (e.g., ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, and avelumab). In view of such progress, there have been only relatively limited efforts toward developi

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Fang, Deyu. "Deleted in breast cancer 1 (DBC1) is a molecular checkpoint of B cell autoimmunity (BA2P.130)." Journal of Immunology 192, no. 1_Supplement (2014): 45.17. http://dx.doi.org/10.4049/jimmunol.192.supp.45.17.

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Abstract Self-reactive B cells in the periphery are maintained in a tolerized state through low levels of sCD40L and BAFF (B-cell Activating Factor) signaling. Loss of tolerance due to hyperproduction of CD40L or BAFF, or uncontrolled downstream signaling following activation is associated with multiple autoimmune diseases. In this study we identify Deleted in Breast Cancer 1 (DBC1) as a novel suppressor of B cell activation and autoantibody production. Mice with targeted deletion of Dbc1 gene have hyper-responsive B cells, which produce immunoglobulin, in particular IgG and IgA isotypes, agai

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Kumar, Gaurav, Kaylea Massey, Rose M. Ko, and Robert C. Axtell. "BAFF and APRIL signaling through B cell maturation antigen affects regulatory transitional B cells in multiple sclerosis." Journal of Immunology 210, no. 1_Supplement (2023): 238.11. http://dx.doi.org/10.4049/jimmunol.210.supp.238.11.

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Abstract Multiple sclerosis (MS) is a debilitating neuro-autoimmune disease that can be stratified into relapsing remitting (RR) MS, secondary progressive (SP) MS, and primary progressive (PP) MS. B cells can have both inflammatory and regulatory functions in MS. Transitional B cells are considered to have regulatory functions in MS. BAFF and APRIL, two cytokines, signals through the receptors BAFFR, TACI and BCMA and are thought to drive the regulatory function of transitional B cells. Here, we assessed the frequencies and expression of BAFFR, TACI and BCMA on the surface of regulatory transi

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Yaccoby, Shmuel, Stacey R. Dillon, Wen Ling, et al. "Atacicept (TACI-Ig) Inhibits Growth of TACIhigh Primary Myeloma Cells in SCID-Hu Mice." Blood 108, no. 11 (2006): 842. http://dx.doi.org/10.1182/blood.v108.11.842.842.

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Abstract Two TNF family members known to play key roles in normal B cell biology, BLyS/BAFF (B-lymphocyte stimulator/B cell activating factor) and APRIL (A PRoliferation-Inducing Ligand), also promote the survival of various malignant B cell types, including multiple myeloma (MM). BLyS binds to 3 TNF-R-related receptors, BCMA (B-cell maturation antigen, TACI (transmembrane activator and CAML interactor), and BAFF-R (BAFF-receptor), whereas APRIL binds to TACI and BCMA and to heparan sulfate proteoglycans (HSPG) such as CD138. All MM cells express HSPG and one or more of these 3 receptors, and

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Zikherman, Julie, Kristin Doan, William Raschke, and Arthur Weiss. "Titration of CD45 expression regulates sequential tolerance checkpoints during B cell development (45.2)." Journal of Immunology 186, no. 1_Supplement (2011): 45.2. http://dx.doi.org/10.4049/jimmunol.186.supp.45.2.

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Abstract The receptor-like tyrosine phosphatase CD45 positively regulates antigen receptor (AgR) signaling by dephosphorylating the inhibitory tyrosine of the Src family kinases (SFKs). Here we take advantage of an allelic series of mice in which CD45 expression is titrated across a broad range (0-180%). Although high expression of CD45 inhibits TCR signaling, here we show that CD45 plays a purely positive regulatory role during BCR signaling. In concert with enhanced BCR signaling, mice expressing very high levels of CD45 exhibit marked loss of follicular and marginal zone B cells in a cell i

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Yu, Tianshu, Ming Hou, Xinguang Liu, and Panpan Han. "Abnormal Microenvironment of Bone Marrow B Lymphocytes in Patients with Primary Immune Thrombocytopenia." Blood 132, Supplement 1 (2018): 3759. http://dx.doi.org/10.1182/blood-2018-99-117581.

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Abstract BACKGROUNDS: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by peripheral blood platelet count<100x10^9/L and increased risk of bleeding, but its exact pathogenesis remains unclear. Previous researches mostly emphasized on periphral blood, in order to elucidate the pathogenesis and provide new strategies for treatment, a series of studies about bone marrow B cells were carried out in our investigation. METHODS: 5ml bone marrow blood samples from 11 newly diagnosed ITP patients and 7 allo-HSCT healthy donors were collected into heparin anticoagulant tu

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Kottorou, Anastasia E., Foteinos-Ioannis D. Dimitrakopoulos, Anna G. Antonacopoulou та ін. "Association of overexpression of TNF receptor superfamily members (CD40, BAFFR, LTβR and RANK) with favorable prognosis in patients with colorectal adenocarcinoma." Journal of Clinical Oncology 42, № 16_suppl (2024): e15516-e15516. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e15516.

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e15516 Background: Numerous studies by our and other groups have highlighted the implication of NF-κB in colorectal cancer (CRC) through the deterioration of classical and alternative pathway signaling. The alternative pathway of NF-κB can be activated by members of TNF superfamily, such as lymphotoxin β (LTβ), tumor necrosis factor ligand superfamily member 5 (CD40L), B-cell activation factor (BAFF) and receptor activator of NF-κB ligand (RANKL). We have previously shown that alternative pathway of NF-κΒ is deteriorated in CRC. In the present study, we investigated the clinical significance o

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Wang, Xiuli, Zhenyuan Dong, Wen-Chung Chang, et al. "CD19/BAFF-R Dual-Targeted CAR T Cells for the Treatment of Mixed Antigen-Negative Variants of Acute Lymphoblastic Leukemia." Blood 138, Supplement 1 (2021): 2783. http://dx.doi.org/10.1182/blood-2021-151293.

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Abstract The results of clinical trials evaluating CD19-targeting chimeric antigen receptor (CAR) T cells are impressive, with overall response rates of up to 90% in B cell acute lymphoblastic leukemia (ALL) and 50-80% in lymphoma. Despite initial responses, antigen-negative relapse is common following treatment with CD19-targeted therapies and is estimated to occur in up to 39% of patients. One approach of addressing this problem is to utilize dual-targeting CAR T cells, a strategy that has recently been applied to CD19/CD22 for ALL, CS1/BCMA, and BCMA/GPRC5D for multiple myeloma. Dual-target

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Malyshkina, Anna I., Natalia Y. Sotnikova, Dmitriy N. Voronin, and Alena V. Kust. "Regulation of the functional activity of peripheral B lymphocytes in pregnant women with a history of recurrent miscarriage." Journal of obstetrics and women's diseases 70, no. 4 (2021): 73–79. http://dx.doi.org/10.17816/jowd62675.

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BACKGROUND:The frequency of recurrent miscarriage is up to 5 % of all desired pregnancies and is mainly due to immunological disorders. Dysfunction in the regulation of the functional activity of B lymphocytes is the pathogenetic link in multiple obstetric complications, including habitual miscarriage. AIM:The aim of this study was to characterize the regulation of the functional activity of peripheral B lymphocytes in pregnant women with threatened spontaneous miscarriage and a history of habitual miscarriage. MATERIALS AND METHODS:We examined 88 women aged 18-40 years at a gestat

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Malyshkina, Anna I., Natalia Y. Sotnikova, Dmitriy N. Voronin, and Alena V. Kust. "Regulation of the functional activity of peripheral B lymphocytes in pregnant women with a history of recurrent miscarriage." Journal of obstetrics and women's diseases 70, no. 4 (2021): 73–79. http://dx.doi.org/10.17816/jowd62675.

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BACKGROUND:The frequency of recurrent miscarriage is up to 5 % of all desired pregnancies and is mainly due to immunological disorders. Dysfunction in the regulation of the functional activity of B lymphocytes is the pathogenetic link in multiple obstetric complications, including habitual miscarriage. AIM:The aim of this study was to characterize the regulation of the functional activity of peripheral B lymphocytes in pregnant women with threatened spontaneous miscarriage and a history of habitual miscarriage. MATERIALS AND METHODS:We examined 88 women aged 18-40 years at a gestat

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Kumar, Gaurav, Kaylea Massey, Rose Ko, and Robert Axtell. "B cell Maturation Antigen Impacts Microglia and Macrophage Phenotypes in Neuro-autoimmune disease." Journal of Immunology 212, no. 1_Supplement (2024): 1406_5218. http://dx.doi.org/10.4049/jimmunol.212.supp.1406.5218.

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Abstract BAFF and APRIL, crucial to B cell function, play a role in multiple sclerosis (MS), with therapeutic blockade linked to worsened disease. These cytokines signal through the receptors: BAFFR, TACI, and BCMA. BCMA stands out in MS due to elevated soluble levels in the cerebrospinal fluid. Our prior study using EAE revealed increased disease severity in BCMA knockout mice. Additionally, BCMA showed divergent roles in response to anti-CD20 and TACI-Fc treatments in EAE, enhancing anti-CD20 therapy responsiveness but diminishing TACI-Fc efficacy. The contrasting effects of BCMA on these tr

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Junaid, Muhammad, Azmat Kamran, Suriyakala Perumal Chandran, and Irfan Ali. "AGE-RELATED EFFECTS OF DONOR ON CORNEAL TRANSPLANTATION AND CLINICAL STUDY OF CASUAL ALLOGRAFT REJECTION IN PAKISTAN." Insights-Journal of Health and Rehabilitation 3, no. 3 (Health & Allied) (2025): 353–60. https://doi.org/10.71000/wypqka87.

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Background: Corneal transplantation is a widely used procedure to restore vision in patients with corneal blindness. Donor age is considered a critical factor influencing graft survival, visual acuity, and allograft rejection. However, the impact of donor age on corneal transplantation outcomes remains a subject of debate. This study aims to evaluate the effects of donor age on graft clarity, visual outcomes, and rejection rates in a Pakistani population, addressing gaps in regional transplantation practices and guiding future donor selection criteria. Objective: The study investigates the rel

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Smulski, Cristian R., Patrick Kury, Lea M. Seidel, et al. "BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells." Cell Reports 18, no. 9 (2017): 2189–202. http://dx.doi.org/10.1016/j.celrep.2017.02.005.

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Misra, Ravi S., Guixiu Shi, Miguel E. Moreno-Garcia та ін. "Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity". Journal of Experimental Medicine 207, № 8 (2010): 1775–89. http://dx.doi.org/10.1084/jem.20092735.

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Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gαq subunit of trimeric G proteins (Gnaq−/− mice) have an intrinsic survival advantage over normal B cells, even in the absence of BAFF. Gnaq−/− B cells develop normally in the bone marrow but inappropriately survive peripheral tolerance checkpoints, leading to the accumulation of transitional, marginal zone, and follicular B cells, many of which are autoreactive. Gnaq−/− chimeric mice rapidly develop arthritis as well as other manifestations of systemic autoimmune

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Nelke, Johannes, Juliane Medler, Daniela Weisenberger, Andreas Beilhack, and Harald Wajant. "CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism." mAbs 12, no. 1 (2020): 1807721. http://dx.doi.org/10.1080/19420862.2020.1807721.

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Day, Eric S., Teresa G. Cachero, Fang Qian, et al. "Selectivity of BAFF/BLyS and APRIL for Binding to the TNF Family Receptors BAFFR/BR3 and BCMA." Biochemistry 44, no. 6 (2005): 1919–31. http://dx.doi.org/10.1021/bi048227k.

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Budde, Lihua Elizabeth, Marissa Del Real, John H. Baird, et al. "PMB-CT01 (BAFFR-CAR T cell) therapy to examine preliminary safety and clinical responses in patients with B-cell malignancies who are ineligible for or failed CD19-directed therapy, including CD19-negative disease." Journal of Clinical Oncology 42, no. 16_suppl (2024): 6534. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.6534.

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6534 Background: CD19-targeted therapies have shown remarkable efficacy in patients with B-cell malignancies. However, relapse with CD19 loss as a mechanism of tumor escape is common and represents a serious challenge. Patients who are ineligible for or have failed prior CD19-directed therapy have limited salvage options and a very poor prognosis. The B-cell activating factor receptor (BAFF-R) is functionally expressed in B-cell acute lymphoblastic leukemia (B-ALL) and non-Hodgkin lymphomas (NHL), including in patients with CD19-negative relapse (Qin et al., Sci Transl Med. 2019). As a critica

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Leleu, Xavier, Lian Xu, Zachary R. Hunter, et al. "Abnormal Expression of TRAF Adapter Proteins in Waldenstrom’s Macroglobulinemia." Blood 108, no. 11 (2006): 4640. http://dx.doi.org/10.1182/blood.v108.11.4640.4640.

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Abstract Background: Waldenström’s Macroglobulinemia (WM) is an incurable low-grade lymphoplasmacytic lymphoma with as yet unknown genetic basis for its pathogenesis. Several TNF family members (CD40L, APRIL and BAFF/BLYS) are known to regulate WM growth and survival. TRAFs are a novel family of adapter proteins that facilitate pro-apoptotic (TACI) or pro-survival/differentiation (CD40, BAFFR, BCMA) receptor signaling mediated by TNF family ligands. Therefore, understanding the TRAF system in WM may yield important clues about WM growth and survival. Methods: WM cell lines (BCWM.1 and WSU-WM)

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Graves, Jake Martin, and Conan Coatsworth. "BAFTA 2015." Alphaville: Journal of Film and Screen Media, no. 9 (October 27, 2015): 138–43. http://dx.doi.org/10.33178/alpha.9.12.

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Bossen, Claudia, Teresa G. Cachero, Aubry Tardivel, et al. "TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts." Blood 111, no. 3 (2008): 1004–12. http://dx.doi.org/10.1182/blood-2007-09-110874.

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Abstract The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF (BAFF 3-mer) were compared with those of higher-order BAFF oligomers. All forms of BAFF bound BAFF-R and TACI, and elicited BAFF-R–dependent signals in primary B cells. In contrast, signaling through TACI in mature B cells or plasmablasts was only achieved by higher-order BAFF and APRIL oligomers, all of which were also po-tent activators of a multimerization-dependent reporter signaling pathway. These results indicate

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Dimtrakopoulos, Fotinos-Ioannis D., Anastasia E. Kottorou, Anna G. Antonacopoulou, et al. "Association of BAFFR expression in CAFs with overall survival and response to platinum-based chemotherapy in NSCLC." Journal of Clinical Oncology 37, no. 15_suppl (2019): 8537. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.8537.

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8537 Background: Β-cell activating factor receptor (BAFFR) is a surface receptor, which leads to activation of the Nuclear Factor-kappaB (NF-κB) alternative pathway, a pathway with an important role in non-small cell lung cancer (NSCLC). In addition, cancer associated fibroblasts (CAFs) are major players of the tumor microenvironment promoting NSCLC. The aim of this study was to assess the possible associations of BAFFR expression in CAFs with response to first-line chemotherapy doublet and clinical outcome of NSCLC patients. Methods: Immunohistochemical analysis of BAFFR expression on CAFs wa

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