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Journal articles on the topic 'BAG-S53P4'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Coraça-Huber, Débora, Manfred Fille, Johann Hausdorfer, David Putzer, and Michael Nogler. "Efficacy of Antibacterial Bioactive Glass S53P4 Against S. aureus Biofilms Grown on Titanium Discs In Vitro." Journal of Orthopedic Research 32 (September 25, 2013): 175–77. https://doi.org/10.1002/jor.22463.

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ABSTRACT: We evaluated the effectiveness of different sizes of bioactive glass S53P4 against Staphylococcus aureus biofilms grown on metal discs in vitro. S. aureus biofilms were cultivated on titanium discs. BAG-S53P4 (0.5–0.8mm and <45 mm) were placed in contact with the discs containing biofilms. Glass beads (0.5mm) were used as a control. After each interval, the pH from each sample was measured. Colony forming units were counted for the biofilm recovery verification. In parallel, we tested the activity of bioactive glass against S. aureus planktonic cells. We found that BAG-S53P4

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2

Björkenheim, R., E. Jämsen, E. Eriksson, et al. "Sintered S53P4 bioactive glass scaffolds have anti-inflammatory properties and stimulate osteogenesis in vitro." European Cells and Materials 41 (January 3, 2021): 15–30. http://dx.doi.org/10.22203/ecm.v041a02.

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Bioactive glasses (BAG) are used as bone-graft substitutes in orthopaedic surgery. A specific BAG scaffold was developed by sintering BAG-S53P4 granules. It is hypothesised that this scaffold can be used as a bone substitute to fill bone defects and induce a bioactive membrane (IM) around the defect site. Beyond providing the scaffold increased mechanical strength, that the initial inflammatory reaction and subsequent IM formation can be enhanced by coating the scaffolds with poly(DL-lactide-co-glycolide) (PLGA) is also hypothesised. To study the immunomodulatory effects, BAG-S53P4 (± PLGA) sc

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Malat, Tarek Al, Martin Glombitza, Janosch Dahmen, Peter-Michael Hax, and Eva Steinhausen. "The Use of Bioactive Glass S53P4 as Bone Graft Substitute in the Treatment of Chronic Osteomyelitis and Infected Non-Unions – a Retrospective Study of 50 Patients." Zeitschrift für Orthopädie und Unfallchirurgie 156, no. 02 (2018): 152–59. http://dx.doi.org/10.1055/s-0043-124377.

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Abstract Background Treatment of chronic osteomyelitis (COM) remains challenging and often results in large bone defects. Dead space management and proper defect filling are essential for successful treatment. Bioactive glass S53P4 (BAG-S53P4) is an anorganic bone graft substitute with antibacterial, osteoconductive, osteostimulative and angiogenic properties. The aim of our study was to analyse the outcome of patients with COM and infected non-unions, whose bone defects were filled with BAG-S53P4. Material and Methods In this retrospective study (07/13 – 02/16), we analysed all patients with

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Putzer, David, Johannes Fuchs, Débora Coraça-Huber, Christoph Ammann, Michael Liebensteiner, and Michael Nogler. "BAG-S53P4 as an Additive to Bone Allografts: A Laboratory Study Using an Uniaxial Compression Test." J Orthop Res 33 (June 12, 2015): 1875–79. https://doi.org/10.1002/jor.22953.

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ABSTRACT: We want to address the clinical issue of too sparse supply of allograft in total hip replacement and ambitions of controlling the grain size distribution. Bioglass BAG-S53P4 was evaluated as a bone graft additive to chemically treated allografts with controlled grain size distribution. Allografts were chemically cleaned (CG) and mixed with BAG-S53P4 additive (BG) for comparison. All samples were compacted with a dropped weight apparatus and then underwent a uniaxial compression test. The yield limit was determined by a uniaxial compression test and density was recorded while flowabil

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Dell’Aquila, Adriana Macedo, Gabriela Nagy Baldy dos Reis, Gabriel Trova Cuba, et al. "Outcome and Predictors of Treatment Failure in Chronic Osteomyelitis Using Bioactive Glass Granules and Putty Formulations." Antibiotics 12, no. 12 (2023): 1720. http://dx.doi.org/10.3390/antibiotics12121720.

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Background: The aim of this study is to evaluate the outcome of patients with cavitary chronic osteomyelitis undergoing adjuvant treatment with bioactive glass (BAG) S53P4 and identify the independent risk factors (RFs) for recurrence in 6- and 12-month patient follow-up. Methods: A retrospective, multicentre observational study conducted in tertiary specialised hospitals among patients undergoing the surgical treatment of chronic cavitary osteomyelitis using BAG-S53P4 in a granule and/or putty formulation to assess the clinical outcome and RFs for failure in 6- and 12-month patient follow-up.

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van Gestel, Nicole A. P., Floor Gabriels, Jan A. P. Geurts, et al. "The Implantation of Bioactive Glass Granules Can Contribute the Load-Bearing Capacity of Bones Weakened by Large Cortical Defects." Materials 12, no. 21 (2019): 3481. http://dx.doi.org/10.3390/ma12213481.

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Bioactive glass (BAG) granules (S53P4) have shown good clinical results in one-stage treatment of osteomyelitis. During this treatment, a cortical window is created, and infected bone is debrided, which results in large defects that affect the mechanical properties of the bone. This study aimed to evaluate the role of BAG granules in load-bearing bone defect grafting. First, the influence of the geometry of the cortical window on the bone bending stiffness and estimated failure moments was evaluated using micro finite element analysis (µFE). This resulted in significant differences between the

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Grassi, Miriam, Marco Mattia Larghi, Davide Brioschi, Marianatonietta Scazzarriello, and Alfonso Manzotti. "A case of chronic ankle osteomyelitis treated with bioactive glass and tibiocalcaneal fusion." Journal of the Foot & Ankle 19, no. 1 (2025): 1–5. https://doi.org/10.30795/jfootankle.2025.v19.1832.

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Limb-salvage surgery in cases of chronic osteomyelitis poses significant challenges for orthopedic surgeons. This case report presents the first documented instance of a successful staged limb-salvage treatment for chronic ankle osteomyelitis, combining tibiocalcaneal fusion with bioactive glass (BAG). Bioactive glass S53P4 is a synthetic, biocompatible, osteoconductive bone substitute known for its bone-bonding capabilities, antibacterial and angiogenesis-promoting properties, which could be suitable for treating bone defects in infections. The subject of this case is a 68-year-old male with

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Peltola, Matti, Kalle Aitasalo, Teemu Tirri, Jami Rekola, and A. Puntala. "Long-Term Tissue Reactions of Three Biomaterials in Craniofacial Surgery." Key Engineering Materials 361-363 (November 2007): 1343–46. http://dx.doi.org/10.4028/www.scientific.net/kem.361-363.1343.

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Successful craniofacial reconstruction needs both a well-known and a reliable reconstruction material. However, there is often a lack of long-term knowledge of the tissue reactions and healing process in the human body. In this study, frontal sinus obliterations with bovine bone natural hydroxyapatite derivative (BHA), synthetic bioactive glass S53P4 (BAG) and hydroxyapatite cement (HAC) were investigated with clinical, histologic, scanning electron microscopic (SEM) and energy dispersive x-ray analysis (EDXA) 27, 12 and 3 years postoperatively. The aim was to determine the long-term clinical

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Bortolin, Monica, Elena De Vecchi, Carlo Luca Romanò, Marco Toscano, Roberto Mattina, and Lorenzo Drago. "Antibiofilm agents against MDR bacterial strains: is bioactive glass BAG-S53P4 also effective?" Journal of Antimicrobial Chemotherapy 71, no. 1 (2015): 123–27. http://dx.doi.org/10.1093/jac/dkv327.

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10

Alhotan, Abdulaziz, Zbigniew Raszewski, Katarzyna Chojnacka, et al. "Evaluating the Translucency, Surface Roughness, and Cytotoxicity of a PMMA Acrylic Denture Base Reinforced with Bioactive Glasses." Journal of Functional Biomaterials 15, no. 1 (2023): 16. http://dx.doi.org/10.3390/jfb15010016.

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The colonisation of the surface of removable acrylic dentures by various types of microorganisms can lead to the development of various diseases. Therefore, the creation of a bioactive material is highly desirable. This study aimed to develop a denture base material designed to release bioactive ions into the oral environment during use. Four types of bioactive glasses (BAG)—S53P4, Biomin F, 45S5, and Biomin C—were incorporated into the PMMA acrylic resin, with each type constituting 20 wt.% (10 wt.% non-silanised and 10% silanised) of the mixture, while PMMA acrylic resin served as the contro

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Steinhausen, Eva, Rolf Lefering, Martin Glombitza, et al. "Bioactive glass S53P4 vs. autologous bone graft for filling defects in patients with chronic osteomyelitis and infected non-unions – a single center experience." Journal of Bone and Joint Infection 6, no. 4 (2021): 73–83. http://dx.doi.org/10.5194/jbji-6-73-2021.

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Abstract. Introduction: The goals of osteomyelitis therapy are successful control of infection and reconstruction of the bone. The gold standard for filling defects is the autologous bone graft. Bioactive glass S53P4 is an inorganic bone substitute. We compared the outcome of using bioactive glass (BAG) versus autologous bone graft (AB) in patients with infected non-union. Methods: Patients with chronic osteomyelitis and infected non-union who received either bioactive glass or autologous bone grafts between 2013 and 2017 were analyzed retrospectively. The primary endpoint was successful contr

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12

Zwierz, Aleksander, Marta Staszak, Matthias Scheich, Krzysztof Domagalski, Stephan Hackenberg, and Paweł Burduk. "A Comparison of the Sticky Bone Obliteration Technique and Obliteration Using S53P4 Bioactive Glass After Canal Wall Down Ear Surgery: A Preliminary Study." Journal of Clinical Medicine 14, no. 5 (2025): 1681. https://doi.org/10.3390/jcm14051681.

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Background: The aim of this study was to analyse the results of the mastoid obliteration technique with sticky bone (SB) and compare them with those obtained using bioactive glass S53P4 (BAG). Methods: This prospective preliminary study comprised 28 adults who underwent canal wall down (CWD) surgery using two mastoid obliterative techniques: SB (n = 21) or BAG (n = 7). The SB group was treated with the patients’ own bone dust and injectable platelet rich fibrin (IPRF) (n = 13%) or bone dust, IPRF, and additionally allogenic lyophilised demineralised bone (n = 9%). Results: Nine months after th

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Bortolin, Monica, Carlo L. Romanò, Alessandro Bidossi, Elena De Vecchi, Roberto Mattina, and Lorenzo Drago. "BAG-S53P4 as bone graft extender and antimicrobial activity against gentamicin- and vancomycin-resistant bacteria." Future Microbiology 13, no. 5 (2018): 525–33. http://dx.doi.org/10.2217/fmb-2016-0171.

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14

David, Putzer, Fuchs Johannes, Coraça-Huber Débora, Christoph Ammann, Liebensteiner Michael, and Nogler Michael. "BAG-S53P4 as an additive to bone allografts: A laboratory study using an uniaxial compression test." Journal of Orthopaedic Research 33, no. 12 (2015): 1875–79. http://dx.doi.org/10.1002/jor.22953.

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15

Arrigoni, Paolo, Ilaria Morelli, Stefano Puricelli, Francesca Manfroni, and Domenico Prestamburgo. "Surgical treatment of unstable spondylodiscitis with posterior instrumentation and bioactive glass (BAG-S53P4): surgical technique and results at medium-term follow-up." Journal of Spine Surgery 11, no. 2 (2025): 307–20. https://doi.org/10.21037/jss-25-6.

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16

Findeisen, Sebastian, Niklas Gräfe, Melanie Schwilk, et al. "Use of Bioactive Glass as a Bone Substitute in the Treatment of Large-Sized Bone Defects of the Femur and Tibia." Journal of Personalized Medicine 13, no. 12 (2023): 1644. http://dx.doi.org/10.3390/jpm13121644.

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Background: Managing bone defects in non-union surgery remains challenging, especially in cases of large defects exceeding 5 cm in size. Historically, amputation and compound osteosynthesis with a remaining PMMA spacer have been viable and commonly used options. The risk of non-union after fractures varies between 2% and 30% and is dependent on various factors. Autologous bone grafts from the iliac crest are still considered the gold standard but are limited in availability, prompting consideration of artificial grafts. Objectives: The aims and objectives of the study are as follows: 1. To eva

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17

Ferrando, Albert, Joan Part, and Jose Baeza. "Treatment of Cavitary Bone Defects in Chronic Osteomyelitis: Bioactive glass S53P4 vs. Calcium Sulphate Antibiotic Beads." Journal of Bone and Joint Infection 2, no. 4 (2017): 194–201. http://dx.doi.org/10.7150/jbji.20404.

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Abstract. Aim: To evaluate the efficacy of bioglass (BAG-S53P4) in the treatment of patients with chronic osteomyelitis and compare the results with calcium sulphate antibiotic beads in one medical centre.Methods: Retrospective analysis of 25 cases. Inclusion criteria: patients diagnosed clinically and radiographically of osteomyelitis and treated surgically (Group 1: cavitary bone defects treated with bioglass and Group 2: cavitary bone defects treated with calcium sulphate antibiotic beads) during the period of 2014 and 2015 in one medical centre.Results: Patients in group 1 (bioglass treatm

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18

der Broeck, L. V., J. Geurts, S. Qiu, M. Poeze, and T. J. Blokhuis. "THE INDUCED MEMBRANE TECHNIQUE IMPROVES THE HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH A POST-TRAUMATIC LONG BONE NONUNION." Orthopaedic Proceedings 106-B, SUPP_2 (2024): 104. http://dx.doi.org/10.1302/1358-992x.2024.2.104.

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The optimal treatment strategy for post-traumatic long bone non-unions is subject of an ongoing discussion. At the Maastricht University Medical Center (MUMC+) the induced membrane technique is used to treat post-traumatic long bone non-unions. This technique uses a multimodal treatment algorithm involving bone marrow aspirate concentrate (BMAC), the reamer-irrigator-aspirator (RIA) and P-15 bioactive peptide (iFactor, Cerapedics). Bioactive glass (S53P4 BAG, Bonalive) is added when infection is suspected. This study aims to objectify the effect of this treatment algorithm on the health-relate

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19

Stoor, Patricia, and Janek Frantzen. "Influence of bioactive glass S53P4 granules and putty on osteomyelitis associated bacteria in vitro." Biomedical Glasses 3, no. 1 (2017). http://dx.doi.org/10.1515/bglass-2017-0007.

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AbstractBacterial infection of bone tissue and bone marrow, referred to as osteomyelitis, is a challenging clinical problem. In this study we analysed the influence of the granule size of the bone substitute bioactive glass (BAG) S53P4 and the novel putty material containing BAG S53P4 on four clinically important bacteria associated with osteomyelitis; Staphylococcus aureus, methicillin resistant Staphylococuus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa. Reference materials were the frequently used biomaterial in surgical bone grafting procedures; tricalcium phosphate and an

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Saarenpää, Ilkka, Patricia Stoor, and Janek Frantzén. "BAG S53P4 putty as bone graft substitute – a rabbit model." Biomedical Glasses 3, no. 1 (2017). http://dx.doi.org/10.1515/bglass-2017-0003.

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AbstractBioactive glass (BAG) S53P4 granules represent a bone augmentation biomaterial for the surgical treatment of bony defects, even in challenging conditions such as osteomyelitis. The aim of this eight-week rabbit implantation study was to evaluate the biocompatibility and bone regeneration performance of a BAG S53P4 putty formulation following its implantation into the proximal tibia bone of twenty-eight New Zealand white rabbits. BAG S53P4 putty was compared to BAG S53P4 granules (0.5-0.8 mm) to evaluate whether the synthetic putty binder influences the bone regeneration of the osteosti

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Strömberg, Gustav, Laura Aalto-Setälä, Peter Uppstu, et al. "Development and Characterization of Non-coated and PLGA-Coated S53P4 and S59 Bioactive Glass Scaffolds for Treatment of Load-Bearing Defects." Biomedical Materials & Devices, August 4, 2023. http://dx.doi.org/10.1007/s44174-023-00099-4.

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Abstract We studied how in vitro reactions affect long-term biochemical and mechanical properties of porous tissue engineering scaffolds based on two bioactive glasses and accordingly their potential suitability for treating critical-size load-bearing bone defects. Granules of bioactive glass S53P4 and S59 were used to sinter the porous scaffolds. The sintering variables for mechanically durable scaffolds were initially selected according to the thermal behaviour of the glasses during heating. The S53P4 and S59 scaffolds were further divided into the following three groups: uncoated scaffolds,

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Aalto-Setälä, Laura, Minna Siekkinen, Nina Lindfors, and Leena Hupa. "Dissolution of Glass–Ceramic Scaffolds of Bioactive Glasses 45S5 and S53P4." Biomedical Materials & Devices, January 12, 2023. http://dx.doi.org/10.1007/s44174-022-00059-4.

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AbstractAlthough the initial in vitro dissolution of bioactive glasses (BAG) is well characterized, the long-term behaviour of crystallized BAG scaffolds in a continuous fluid flow is incompletely understood. A detailed understanding of the long-term dissolution of scaffolds is vital for predicting their behaviour in clinical applications. Here, we explored the dissolution and reaction mechanisms of partly crystalline and glass–ceramic scaffolds based on the bioactive glasses S53P4 and 45S5 using a continuous flow-through method in Tris-buffer (Tris) and simulated body fluid (SBF) for up to 21

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Kroon, Victor J., Steven W. Mes, Pepijn A. Borggreven, Rick van de Langenberg, David R. Colnot, and Jasper J. Quak. "Efficacy of S53P4 Bioactive Glass for the Secondary Obliteration of Chronically Discharging Radical Cavities." OTO Open 7, no. 4 (2023). http://dx.doi.org/10.1002/oto2.96.

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AbstractObjectivePresent the results of the secondary obliteration of chronically discharging radical cavities using S53P4 bioactive glass (BAG).Study DesignRetrospective cohort study.SettingSingle‐center study.MethodsA single‐center retrospective cohort study was conducted of all patients that underwent secondary obliteration of persistently draining radical cavities using S53P4 BAG between 2011 and 2022. Patients with middle ear cholesteatoma were excluded. The main outcome was postoperative otorrhea, as indicated by Merchant grading.ResultsIn total, 97 patients were included. The median pos

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Kroon, Victor J., Steven W. Mes, Pepijn A. Borggreven, Rick van de Langenberg, David R. Colnot, and Jasper J. Quak. "Cholesteatoma surgery in the pediatric population: remaining challenges in the era of mastoid obliteration." European Archives of Oto-Rhino-Laryngology, October 8, 2022. http://dx.doi.org/10.1007/s00405-022-07669-0.

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Abstract Purpose To present the first pediatric study on the safety and efficacy of mastoid obliteration using S53P4 bioactive glass (BAG) for cholesteatoma surgery. Methods A single-center retrospective cohort study was conducted. Inclusion criteria were pediatric cases (≤ 18 years) and at least at least one year of follow-up including non-echo planar diffusion-weighted MRI to assess cholesteatoma recidivism. Both canal wall up (CWU) and canal wall down (CWD) procedures were evaluated. Results A total of 61 cases (56 patients) were included. Most cases had an otologic history before the devel

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Cossio, Andrea, Jole Graci, Antonino Salvatore Lombardo, et al. "Bilateral tibial Brodie’s abscess in a young patient treated with BAG-S53P4: case report." Italian Journal of Pediatrics 45, no. 1 (2019). http://dx.doi.org/10.1186/s13052-019-0685-z.

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26

Pearce, Patrick, Vignesh Raman, Liam MacLachlan, and Thorbjorn Loch-Wilkinson. "Experience with bioactive glass S53P4 (BAG-S53P4) granule implantation during the surgical management of spinal infection: Single-centre case series of 19 patients and brief review of literature." World Neurosurgery, July 2025, 124259. https://doi.org/10.1016/j.wneu.2025.124259.

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27

Drago, Lorenzo, Delia Romanò, Elena De Vecchi, et al. "Bioactive glass BAG-S53P4 for the adjunctive treatment of chronic osteomyelitis of the long bones: an in vitroand prospective clinical study." BMC Infectious Diseases 13, no. 1 (2013). http://dx.doi.org/10.1186/1471-2334-13-584.

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28

Van Vugt, T. A. G., J. A. P. Geurts, and T. J. Blokhuis. "Treatment of infected tibial non-unions using a BMAC and S53P4 BAG combination for reconstruction of segmental bone defects: A clinical case series." Injury, September 2020. http://dx.doi.org/10.1016/j.injury.2020.09.029.

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29

Holmström, Axi, Antti Meriläinen, Jere Hyvönen, et al. "Evaluation of bone growth around bioactive glass S53P4 by scanning acoustic microscopy co-registered with optical interferometry and elemental analysis." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-33454-y.

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AbstractBioactive glass (BAG) is a bone substitute that can be used in orthopaedic surgery. Following implantation, the BAG is expected to be replaced by bone via bone growth and gradual degradation of the BAG. However, the hydroxyapatite mineral forming on BAG resembles bone mineral, not providing sufficient contrast to distinguish the two in X-ray images. In this study, we co-registered coded-excitation scanning acoustic microscopy (CESAM), scanning white light interferometry (SWLI), and scanning electron microscopy with elemental analysis (Energy Dispersive X-ray Spectroscopy) (SEM–EDX) to

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