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Dissertations / Theses on the topic 'BAG3 protein'

Author: Grafiati

Published: 10 March 2023

Last updated: 31 July 2025

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1

Guerriero, Luana. "Studio del ruolo della proteina anti-apoptotica BAG3 nel melanoma umano." Doctoral thesis, Universita degli studi di Salerno, 2016. http://hdl.handle.net/10556/2350.

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2014 - 2015<br>BAG3 protein, a member of BAG family of co-chaperones, has a pro-survival role in several tumor types. BAG3 anti-apoptotic properties rely on its characteristic to bind several intracellular partners, thereby modulating crucial events such as apoptosis, differentiation, cell motility and autophagy. In human melanomas, BAG3 positivity is correlated with the aggressiveness of the tumor cells and can sustain IKK-γ levels, allowing a sustained activation of NF-B. Furthermore, BAG3 is able to modulate BRAFV600E levels and activity in thyroid carcinomas. BRAFV600E mutation is the mo

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2

Knezevic, Tijana. "TRANSLATIONAL APPROACH TO INVESTIGATE INVOLVEMENT OF BAG3 IN PROTEIN QUALITY CONTROL AND HEART FAILURE." Diss., Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/374885.

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Biology<br>Ph.D.<br>Heart failure continues to be a global problem, even with all the drugs currently available, leading to a need of new therapeutics to decrease incidence of heart failure. Heart failure is the inability of the heart muscle to pump sufficient blood and oxygen to the rest of the body. One of the causes of heart failure is cardiomyopathy, where cardiac muscle becomes larger and weaker. Genetic mutations in genes encoding sarcomeric, structural and cytoskeletal proteins were found in families that developed cardiomyopathy. Our laboratory has indentified a family with heart failu

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3

Falco, Antonia. "Ruolo della proteina BAG3 nel microambiente tumorale." Doctoral thesis, Universita degli studi di Salerno, 2012. http://hdl.handle.net/10556/293.

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2009 - 2010<br>Recenti studi hanno dimostrato che il microambiente tumorale subisce numerosi cambiamenti nel corso dello sviluppo del tumore e influenza l’evoluzione e la progressione del cancro. L'ambiente ipossico del tumore stimola l'angiogenesi che può direttamente promuovere la sopravvivenza delle cellule tumorali e la loro invasione. Anche l'infiltrato infiammatorio, associato a molti tumori solidi, è in grado di modulare il comportamento delle cellule tumorali, con effetti anti- e pro-tumorali. Un ruolo importante è svolto anche dai fibroblasti che circondano il tumore, i quali sono in

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4

Koay, Yee Hui. "The role of BAG6 in protein quality control." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-bag6-in-protein-quality-control(75b6fdaa-5c34-4328-b1b8-9f8ba3b94c58).html.

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Proteins must be folded into their correct three-dimensional structure for functions. Failure of proteins to achieve their native conformation is harmful to cells because these proteins are prone to aggregate and engage in non-native interactions. Cells possess extensive protein quality control systems to deal with misfolded proteins, either by refolding the proteins or degrading terminally misfolded proteins. BAG6 has been implicated in cellular protein quality control systems, specifically by recognising stretches of hydrophobic amino acids, recruiting E3 ubiquitin ligase(s) to promote subst

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5

Manchen, Steven T. "Characterization and subcellular localization of the human BAT3 protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62248.pdf.

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6

Iorio, Vittoria. "Determinazione del ruolo della proteina BAG3 nelle isole del Langerhans e suo coinvolgimento nel meccanismo di secrezione dell’insulina." Doctoral thesis, Universita degli studi di Salerno, 2015. http://hdl.handle.net/10556/2041.

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2012 - 2013<br>Diabetes is a metabolic alteration due to a decrease in activity of insulin. In particular, it may be a consequence of a reduced availability of this hormone, of an impediment to its normal action, or of a combination of these two factors. The secretion of insulin is a specialized activity of t β cells of the Langerhans islets that are functional endocrine pancreatic part. Diabetes is a widespread disease, particularly in so-called affluent countries, where some risk factors promotes the onset. Actually, it should be considered a syndrome more complex than the simple hyper

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7

Casson, Joe. "Investigating the role of TRC40 in post-translational protein delivery and quality control." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-role-of-trc40-in-posttranslational-protein-delivery-and-quality-control(02dac94c-857b-4c66-9ea7-8813241dcbce).html.

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Membrane compartmentalisation allows eukaryotic cells to perform complex processes by combining dedicated sets of proteins in the same organelle. To achieve this, the cell must first target the appropriate proteins, primarily synthesised on cytosolic ribosomes, to the correct subcellular location. Components of the secretory pathway/endomembrane system begin this journey via their signal sequence-dependent delivery to the endoplasmic reticulum (ER). These ER targeting signals are hydrophobic, and typically function whilst the protein is being synthesised, via a so-called 'co-translational' pat

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8

Witcher, Michael. "Interaction of the anti-apoptotic protein BAG-1 with the vitamin D receptor." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0010/MQ52698.pdf.

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9

Wood, Jemma Claire. "The function of Bag-1 proteins in epidermal squamous cell carcinoma." Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550326.

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The incidence of epidermal squamous cell carcinoma (SCC) has increased significantly over recent years, largely due to increased exposure to its major aetiological factor, UVB radiation. Despite its increasing prevalence, relatively little is known regarding the genetic changes involved in SCC development. The aim of this study was to investigate the potential involvement of the anti-apoptotic protein BcI-2-associated athanogene-l (Bag-i), which shows deregulated expression in a range of human tumours, in epidermal SCC development, in addition to investigating a potential functional role for B

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10

Clemo, Nadine Kathryn. "The role of the anti-apoptotic protein BAG-1 in colorectal tumour cell survival." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441659.

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11

Crocoll, Alexander [Verfasser]. "Expression und antiapoptotische Funktion des Bag-1 Proteins während der Embryonalentwicklung der Maus / Alexander Crocoll." Karlsruhe : KIT-Bibliothek, 2001. http://d-nb.info/1198221933/34.

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12

Brunn, Jonathan. "Investigation of Possible Novel Peptide Inhibitors to BAG-1 Based On Peptidyl-Biomimetics." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/2942.

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In this Master’s Thesis Research the results can be summarized from two major tasks: (1) In our first task, we utilized our two protein system (BAG-1 and HSP 70) as part of beta testing of a computational software 1 that can take three dimensional x-ray crystallography information about protein complexes and predict the strength of atom –atom interactions between amino-acid residues Open Contact predicts binding hotspots that can be used to identify short amino acid chains or peptides that mimic that particular binding segment of the larger protein. These peptides are called pepidyl-biom

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13

Aveic, Sanja. "Role of BCL-2 associated athanogene - 1 (BAG-1) in Acute Myeloid Leukemia (AML): protein with hundred faces." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3427500.

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Bcl-2 associated AthanoGene-1 (BAG-1) is a multifunctional protein competent to delay cell death by a synergistic action with Bcl-2. BAG-1, as well as Bcl-2, has been reported as deregulated in diverse cancer types. During PhD study, we confirmed BAG-1 protein as over-expressed in a cohort of leukemic cell lines and heterogeneously expressed in patients affected by de novo acute myeloid or lymphoid leukemia. Silencing approach, used for a determination of BAG-1’s role in AML, suggested a correlation between BAG-1 down-regulation and decreased expression of certain proteins, which contribution

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14

Arhel, Nathalie Jane. "Interaction with the retinoblastoma protein modulates the subcellular localisation of BAG-1 in human colonic epithelial cells : implication for apoptosis." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390993.

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15

Ding, Zhihu. "Role of apoptosis in multidrug resistance and tumorigenesis of human cervical cells, implication of BAG-1 and other apoptotic proteins." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0020/MQ54879.pdf.

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16

Faida, Lena [Verfasser], Pawel [Akademischer Betreuer] Kermer, Ralph [Akademischer Betreuer] Kehlenbach, Holger [Akademischer Betreuer] Reichardt, and Thomas [Akademischer Betreuer] Crozier. "Die Funktion des BAG1-Proteins ist abhängig von seiner subzellulären Verteilung / Lena Faida. Gutachter: Ralph Kehlenbach ; Holger Reichardt ; Thomas Crozier. Betreuer: Pawel Kermer." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2011. http://d-nb.info/1042691517/34.

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17

Sondermann, Holger. "Structure function analysis of the Hsp70 cochaperone Bag-1 Characterization of a monocyte, macrophage specific receptor for heat shock protein 70 ; vorgelegt von Holger Sondermann." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962859613.

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18

Karbaschi, Mohammad Reza. "Structural, physiological and molecular characterisation of the Australian native resurrection grass Tripogon loliiformis (F.Meull) C.E.Hubb during dehydration and rehydration." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/90050/1/Mohammad%20Reza_Karbaschi_Thesis.pdf.

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There is an urgent need to develop crops that can withstand future climates. Results from this thesis demonstrated that a native Australian resurrection grass exhibits structural, physiological and metabolic strategies to tolerate drying. These strategies may be utilized for the generation of stress tolerant crops.

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19

Green, Andrew. "Computational techniques for fast Monte Carlo validation of proton therapy treatment plans." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/computational-techniques-for-fast-monte-carlo-validation-of-proton-therapy-treatment-plans(96ab69f6-9ec3-44e5-ba13-c3021bfa4d59).html.

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Proton therapy is an established radiotherapy technique for the treatment of complex cancers. However, problems exist in the planning of treatments where the use of inaccurate dose modelling may lead to treatments being delivered which are not optimal. Most of the problems with dose modelling tools used in proton therapy treatment planning lie in their treatment of processes such as multiple Coulomb scattering, therefore a technique that accurately models such effects is preferable. Monte Carlo simulation alleviates many of the problems in current dose models but, at present, well-validated fu

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20

Peththa, Thanthrige Nipuni. "Dissecting the molecular mechanisms of AtBAG4-mediated stress tolerance." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/235369/1/Nipuni%2BPeththa%2BThanthrige%2BThesis%283%29.pdf.

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Plant biotechnology holds great promise to help meet the supply-demand gaps of agriculture to feed the future population. This thesis investigated the molecular mechanisms of stress tolerance conferred by the Arabidopsis thaliana Bcl-2 associated athanogene 4 (AtBAG4), cytoprotective protein. The research identified a role for AtBAG4 in several plant stress response pathways and further investigated the implications of expressing AtBAG4 in chickpeas. The AtBAG4-chickpea were equivalent to commercially available chickpea in non-stressed conditions but supported improved yields under drought. Th

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21

Wassbjer, Mattias. "Analysis of the relation between RNA and RBPs using machine learning." Thesis, Linnéuniversitetet, Institutionen för datavetenskap och medieteknik (DM), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-107092.

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The study of RNA-binding proteins has recently increased in importance due to discoveries of their larger role in cellular processes. One study currently conducted at Umeå University involves constructing a model that will be able to improve our knowledge about T-cells by explaining how these cells work in different diseases. But before this model can become a reality, Umeå Univerity needs to investigate the relation between RNA and RNA-binding proteins and find proteins of which highly contribute to the activity of the RNA-binding proteins. To do so, they have decided to use four penalized re

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22

Gonska, Nathalie. "Proton pathways in energy conversion : K-pathway analogs in O2- and NO-reductases." Doctoral thesis, Stockholms universitet, Institutionen för biokemi och biofysik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-147267.

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Oxygen and nitric oxide reductases are enzymes found in aerobic and anaerobic respiration, respectively. Both enzyme groups belong to the superfamily of Heme-Copper Oxidases, which is further divided into several subgroups: oxygen-reducing enzymes into A-, B- and C-type and nitric oxide reductases into qNORs and cNORs. Oxygen reducing enzymes use the energy released from oxygen reduction to take up electrons and protons from different sides of the membrane. Additionally, protons are pumped. These processes produce a membrane potential, which is used by the ATP-synthase to produce ATP, the univ

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23

Colvin, Teresa. "The heat shock protein HSP70 affects cancer signaling via its interaction with co-chaperone BAG3." Thesis, 2016. https://hdl.handle.net/2144/15264.

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HSP70 plays an important role in cancer development. However, the molecular role of HSP70 in cancer is poorly understood. Previous work from our laboratory demonstrated that HSP70 is essential for initiation of Her2-positive breast cancer by controlling oncogene-induced senescence. Here we demonstrate that HSP70 is critical for both initiation and progression of mammary cancer. Interestingly, the role of HSP70 in cancer development did not involve its canonical function as a molecular chaperone. Instead, HSP70 had multiple effects on signaling pathway components related to tumor initiation,

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24

Resende, Daniel Marcos da Silva. "Impact of ER stress and its reversion via chemical chaperones, on age- and proteostasis-associated pathways." Master's thesis, 2019. http://hdl.handle.net/10773/28430.

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Aging remains to this day one of the unresolved biology areas of upmost importance and many age-related diseases are on the rise worldwide. One of aging major hallmarks, proteostasis, has several associated pathways across different segments which have not yet been fully detailed in various cell lines and are needed to better understand the underlying aging problem. Here, using a neuronal-like cell line such as SH-SY5Y, several ER stress biomarkers and proteostasis associated targets are evaluated under ER stress-induced environment through tunicamycin (TUN) or thapsigargin (TG) presence. The

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25

Faida, Lena. "Die Funktion des BAG1-Proteins ist abhängig von seiner subzellulären Verteilung." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B1CF-0.

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26

Leznicki, P., J. Korac-Prlic, K. Kliza, et al. "Binding of SGTA to Rpn13 selectively modulates protein quality control." 2015. http://hdl.handle.net/10454/17894.

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Yes<br>Rpn13 is an intrinsic ubiquitin receptor of the 26S proteasome regulatory subunit that facilitates substrate capture prior to degradation. Here we show that the C-terminal region of Rpn13 binds to the tetratricopeptide repeat (TPR) domain of SGTA, a cytosolic factor implicated in the quality control of mislocalised membrane proteins (MLPs). The overexpression of SGTA results in a substantial increase in steady-state MLP levels, consistent with an effect on proteasomal degradation. However, this effect is strongly dependent upon the interaction of SGTA with the proteasomal component Rpn1

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27

Gamerdinger, Martin [Verfasser]. "Control of protein degradation pathways by BAG proteins and changes during aging / vorgelegt von Martin Gamerdinger." 2009. http://d-nb.info/1000739635/34.

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28

Ho, Quang-Thai, and 胡光泰. "Using Continuous Bag of Words to Interpret the Hidden Information of Protein Sequences in Electron Transport Proteins." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/sn77d4.

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碩士<br>元智大學<br>資訊工程學系<br>106<br>Deep learning, a subset of AI and machine learning, uses multi-layered artificial neural networks to deliver state-of-the-art performance in tasks such as object detection, speech recognition, language translation and so on. In bioinformatics, Deep learning also has been applied to transform biomedical data into valuable knowledge since the early 2000s and demonstrated remarkable scientific achievements nowadays. As a result, it not only shortens the study time but also produces more accurate and reliable results. In this study, I propose a novel approach for ext

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29

Chen, Chia-Chi, and 陳佳琪. "To Characterize the Function of Tid1-Interacting Protein, BAG2, in Oral Squamous Cell Carcinoma Tumorigenesis." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/95218628542902074738.

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碩士<br>國立陽明大學<br>口腔生物研究所<br>103<br>Oral squamous cell carcinoma (OSCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC). Depanding on the data, OSCC mortality rate is increasing year by year. Tid1, a DnaJ cochaperon protein, can bind with HSP70, functions as a tumour suppressor in OSCC tumourigenesis. We previously used systemic proteomics analysis to identify Tid1 interacting protein. The HPD loop of DnaJ domain could bind with HSP70 which on Tid1 was mutated by site-directed mutagenesis. Through affinity chromatography and mass spectrometry we identified BAG2 that specifica

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30

Martínez-Lumbreras, S., E. M. Krysztofinska, A. Thapaliya, et al. "Structural complexity of the co-chaperone SGTA: a conserved C-terminal region is implicated in dimerization and substrate quality control." 2018. http://hdl.handle.net/10454/17888.

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Yes<br>Protein quality control mechanisms are essential for cell health and involve delivery of proteins to specific cellular compartments for recycling or degradation. In particular, stray hydrophobic proteins are captured in the aqueous cytosol by a co-chaperone, the small glutamine-rich, tetratricopeptide repeat-containing protein alpha (SGTA), which facilitates the correct targeting of tail-anchored membrane proteins, as well as the sorting of membrane and secretory proteins that mislocalize to the cytosol and endoplasmic reticulum-associated degradation. Full-length SGTA has an unusu

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