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Author: Grafiati

Published: 4 June 2021

Last updated: 31 July 2024

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Journal articles on the topic "Bai jia xing"

1

Liu, Xiaoyu, Jing Lin, Qing Wang, Siyao Xiao, and Ling Wang. "Prescription rules of Qingzhu Fu, Ziming Chen, and Qian Wu for threatened miscarriage based on traditional Chinese medicine inheritance auxiliary platform." Traditional Medicine and Modern Medicine 03, no. 03 (September 2020): 185–90. http://dx.doi.org/10.1142/s257590002050010x.

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Background: To explore the prescription rules of famous ancient physicians in the treatment of threatened miscarriage. Methods: Traditional Chinese Medicine (TCM) prescriptions for threatened miscarriage were screened out of Fu Ren Da Quan Liang Fang by Ziming Chen, Yi Zong Jin Jian by Qian Wu, and Fu Qing Zhu Nv Ke by Qingzhu Fu. Data were standardized and analyzed through the TCM inheritance auxiliary platform. Results: A total of 29 prescriptions for threatened miscarriage were screened. Dang Gui, E Jiao, Gan Cao, Chuan Xiong, Bai Shao were the top five frequently prescribed Chinese herbs. The common herb–herb combinations used by Ziming Chen contained E Jiao, Dang Gui, Chuan Xiong, Ai Ye, Cong Bai, and Sang Ji Sheng. Ren Shen, Gan Cao, and Bai Zhu were the common herbal groups used by Qingzhu Fu. Huang Qi, Shu Di Huang, Bai Shao, Dang Gui, and Gan Cao were one of Qian Wu’s core prescriptions, with Dang Gui and Chuan Xiong being the others. According to the analysis of four Qi, five flavors, and meridian tropism of the prescriptions, herbs with the warm nature, or with the sweet, pungent, bitter flavors topped the list of application. The top six meridian tropisms of high-frequency herbs were: liver, spleen, lung, kidney, heart, and stomach meridian. Conclusion: Based on the principle of restoring the balance within the organs and enriching Qi and blood, clinical treatment of threatened miscarriage involves invigorating the Chong and Ren channels, nourishing Yin, dispelling cold and wind, generating and activating blood, regulating and harmonizing Qi.

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Jessi Suryani Setiawan, Anindini Winda Amalia, and Lim Lia Harumiaty. "Pengaruh Kombinasi Akupunktur dan Formula Bai Zi Yang Xin Tang Pada Klien Insomnia Sindrom Disharmoni Jantung dan Ginjal di Yayasan Sosial Dharma Warga Surabaya." JURNAL FISIOTERAPI DAN ILMU KESEHATAN SISTHANA 5, no. 2 (July 26, 2023): 37–44. http://dx.doi.org/10.55606/jufdikes.v5i2.429.

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Insomnia is one of the most common diseases in modern society, with its characteristics being difficulty sleeping at night or failure to maintain effective sleep after sleep. Conventional treatments for existing insomnia have undesirable effects when used for a long time. Treatment with acupuncture and herbs can be used as an alternative and complementary therapy in the treatment of insomnia. Research purposes to determine the effect of a combination of acupuncture and herbal therapy Bai Zi Yang Xin Tang on client insomnia with heart and kidney disharmony syndrome at Yayasan Dharma Warga Surabaya. Research methods is one group pre-test and post-test design. Respondents in the study amounted to 14 people received acupuncture therapy at point (Feng Chi, An Mian, Bai Hui, Si Shen Cong, Shen Men, Nei Guan, Zu San Li, San Yin Jiao, Tai Xi, Tai Chong) and consumed Bai Zi Yang Xin Tang. The average length of sleep for respondents before therapy was 3.75 ± 0.47 hours and after therapy 6.0 ± 0.65 hours (p < 0.05). The combination of acupuncture and Bai Zi Yang Xin Tang for insomnia with heart and kidney disharmony syndrome can increase the patient's sleep duration after therapy.

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Qin, Hui, Hao-Tian Wen, Kai-Juan Gu, Xu-Dong Hu, Tao Yang, Xiao-Feng Yan, Ting-Jie Ye, Jin-Lin Huo, and Jing Hu. "Total extract of Xin Jia Xuan Bai Cheng Qi decoction inhibits pulmonary fibrosis via the TGF-β/Smad signaling pathways in vivo and in vitro." Drug Design, Development and Therapy Volume 13 (August 2019): 2873–86. http://dx.doi.org/10.2147/dddt.s185418.

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Pelga, Bella Nitia, and Nova Muhani. "Analisis Risiko Keselamatan dan Kesehatan Kerja pada Proses Produksi Steel Billet di PT. San Xiong Steel Indonesia Tahun 2019." JURNAL DUNIA KESMAS 10, no. 1 (January 23, 2021): 85–95. http://dx.doi.org/10.33024/jdk.v10i1.2985.

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International labour organization (ILO) mencatat 1 pekerja di dunia meninggal setiap 15 detik karena kecelakaan kerja. Angka kecelakaan kerja di Indonesia pada tahun 2017 sebesar 123.000 kasus kecelakaan kerja. PT San Xiong Steel Indonesia bergerak di sektor besi baja. Bahan baku pembuatan besi baja yang digunakan adalah scrap yang di proses melalui proses pemilahan scrap, cooking scrap, analisis laboraturium dan pencetakan. Adanya pemberitaan tentang kecelakaan kerja yang dialami karyawan PT San Xiong Steel Indonesia menjadi alasan bagi peniliti untuk memilih PT San Xiong Steel Indonesia. Tujuan penelitian ini adalah mengetahui tingkat risiko keselamatan dan kesehatan kerja pada proses produksi steel billet di PT San Xiong Indonesia. Jenis penelitian yang digunakan adalah penelitian deskriftif observasional untuk mengidentifikasi bahaya dan menganalisis risiko kecelakaan kerja. Subyek penelitian dalam skripsi ini sebanyak 11 informan. Identifikasi bahaya menggunakan teknik job hazard analysis (jha) dan analisa risiko menggunakan teknik semi kuantitatif yang mengacu pada standar as/nzs 4360:2004 yang mengalikan nilai consequence, exposure, likelihood untuk menentukan tingkat risiko. Hasil penelitian yang didapatkan yaitu dengan tingkat risiko acceptable sebanyak 10 risiko (28%), priority 3 sebanyak 11 risiko (30%) dan 15 risiko (42%) pada tingkat substantial. Saran yang dapat diberikan yaitu melakukan pengukuran pajanan bising, pelatihan ergonomi, menambah alat pelindung diri (apd) sesuai dengan jumlah pekerja dan menambah safety sign.Kata kunci : as/nzs 4360:2004, konsekuensi, pajanan, kemungkinan, level risiko.

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Jin, Jin, Hongchun Zhang, Demin Li, Yue Jing, Zengtao Sun, Jihong Feng, Hong Zhang, et al. "Effectiveness of Xin Jia Xuan Bai Cheng Qi Decoction in treating acute exacerbation of chronic obstructive pulmonary disease: study protocol for a multicentre, randomised, controlled trial." BMJ Open 9, no. 11 (November 2019): e030249. http://dx.doi.org/10.1136/bmjopen-2019-030249.

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IntroductionAcute exacerbation of chronic obstructive pulmonary disease (AECOPD) brings a serious impact on patients’ quality of life, and has extremely high morbidity and mortality worldwide. Although there are many therapies being developed to alleviate symptoms and reduce mortality, a few studies have supported which treatment method is the best. Traditional Chinese medicine (TCM) has shown good potential in the prevention and treatment of AECOPD, especially in terms of supplementation and reduction of dosage and adverse effect of Western medicine. The purpose of this study is to compare the effectiveness of combination of TCM and Western medicine with conventional therapy alone for AECOPD, and to ensure whether the combined therapy may reduce the use of systemic glucocorticoid in AECOPD without influencing efficacy.Methods and analysisA multicentre, randomised, double-blind, placebo-controlled study was conducted to enrol a total of 360 eligible patients who will be randomised into integrated Chinese and Western medicine group A, B and Western standard Medicine group C. After 5 days of intervention and 1 month of follow-up, the efficacy and safety of Xin Jia Xuan Bai Cheng Qi Decoction in patients with AECOPD will be observed. The results of evaluation indicators include: clinical symptoms, biochemical indicators such as blood gas analysis, inflammatory markers, hospitalisation time, TCM syndrome evaluation, biological indicators such as airway, intestinal flora sequencing.Ethics and disseminationThis trail has been approved by the Ethics Committee of China-Japan Friendship Hospital. The results will be disseminated in international peer-reviewed journals and be presented in academic conferences. The results will also be disseminated to patients by telephone, inquiring on patient’s poststudy health status during the follow-up.Trial registration numberChiCTR1800016915

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Chaturvedi, Pallavi, Varghese George, Bai Liu, Niraj Shrestha, Meng Wang, Micheal Dee, Xiaoyun Zhu, et al. "Abstract 1299: Immunotherapeutic hcw9218 enhances anti-tumor activity of chemotherapy by facilitating immune-mediated elimination of therapy induced senescent cells." Cancer Research 82, no. 12_Supplement (June 15, 2022): 1299. http://dx.doi.org/10.1158/1538-7445.am2022-1299.

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Abstract Advances in immunostimulatory and anti-immunosuppressive therapeutics have revolutionized cancer treatment. Here, we report a novel heterodimeric bifunctional fusion molecule, HCW9218, constructed using our soluble tissue factor (TF)-based scaffold technology comprising extracellular domains of the human transforming growth factor-β (TGF-β) receptor II and a human interleukin (IL)-15/IL-15 receptor α complex. This fusion complex exhibited TGF-β neutralizing activity in vitro and sequestered plasma TGF-β in vivo. Subcutaneous administration of HCW9218 was well tolerated in mice, with a half-life sufficient to provide long lasting biological activity. HCW9218 enhanced metabolic and cytotoxic activities of immune cells (CD8+ T cells, NK cells) and reduced tumor progression in models of chemotherapy induced senescence (TIS, docetaxel for B16F10 tumors and gemcitabine plus nab-paclitaxel for SW1990 tumor models) and non-TIS in vivo. Mechanistically, HCW9218 treatment not only affected the immunosuppressive tumor microenvironment but also enhanced CD8+ T cells and NK cells infiltration and cytotoxicity in the tumors to eliminate TIS cancer cells. Immune-depletion studies showed that HCW9218-activated NK cells played a pivotal role in TIS cancer cell removal. HCW9218 treatment following docetaxel chemotherapy further enhanced efficacy of tumor antigen-specific and anti-PDL-1 antibodies in B16F10 tumor-bearing mice. We also show that HCW9218 treatment lowered senescence associated secretory phenotype (SASP) factors in off-target tissues in chemotherapy treated tumor-bearing mice. Thus, HCW9218 may serve as a novel therapeutic (monotherapy or in combination with chemotherapy) to simultaneously provide immunostimulation and lessen immunosuppression associated with tumors. HCW9218 has been cleared by the U.S. Food and Drug Administration to proceed for evaluation in a first-inhuman Phase 1b clinical trial in patients with advanced pancreatic cancer. Citation Format: Pallavi Chaturvedi, Varghese George, Bai Liu, Niraj Shrestha, Meng Wang, Micheal Dee, Xiaoyun Zhu, Jack Egan, Jin-an Jiao, Catherine Spanoudis, Jilan Xing, Victor Gallo, Christian Echeverri, Lijing You, Lin Kong, Gabriela Muniz, Peter Rhode, Hing Wong. Immunotherapeutic hcw9218 enhances anti-tumor activity of chemotherapy by facilitating immune-mediated elimination of therapy induced senescent cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1299.

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Wei, Jia, Qin Liu, Hui Chen, Xin Zhang, Feilong Zhao, Yao Fu, Ju Yang, et al. "Abstract 6176: CD56 dim+ immune infiltration and reprogrammed TMEs associated with response to neoadjuvant anti-PD-1 immunotherapy plus concurrent chemoradiotherapy in locally advanced gastric or gastroesophageal junction adenocarcinoma." Cancer Research 82, no. 12_Supplement (June 15, 2022): 6176. http://dx.doi.org/10.1158/1538-7445.am2022-6176.

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Abstract PURPOSE Neoadjuvant immunotherapy (IO) combined with concurrent chemoradiotherapy (cCRT) showed a good efficacy in treatment of locally advanced gastric or gastroesophageal junction adenocarcinoma (G/GEJC) patients. However, the mechanism of therapeutic efficacy on tumor cells and the tumor microenvironment are still unknown. We aimed to characterize the microenvironment of immune cell infiltration at baseline and post-treatment of the patients in SHARED trial (ChiCTR1900024428). METHODS We prospectively enrolled 18 advanced G/GEJC patients who received IO (sintilimab, anti-PD-L1) in combination with cCRT therapy and resection in Nanjing Drum Tower Hospital. The pre-treatment tumor biopsies samples and post-treatment surgical specimens of all patients were measured for dynamic tumor microenvironment (TME) using mIHC (immune cell markers: CD3, CD4, CD8, FoxP3, CD20, CD56, CD68, CD163, PD-1, PD-L1) in a CLIA-certified laboratory. Twenty-five samples were successfully examined,including 10 paired pre-treatment biopsies and post-treatment specimens, three sole pre-treatment biopsies and two sole post-treatment specimens. RESULTS Among 18 patients who completed neoadjuvant treatment and resection, eight (44.4%) achieved pathological complete response (pCR), and 10 (55.6%) achieved non-pCR (six MPR and four non-MPR). Evaluable pre-treatment samples revealed a significantly higher CD56 dim+ immune infiltration (P=0.018) in pCR tumors compared with non-pCR tumors. Three patients harbored tertiary lymphoid structures (TLSs) in pre-treatment biopsies, two out of three achieved pCR and one achieved MPR. Another one patient harbored TLSs in post-treatment specimens and achieved pCR. No difference was found in all evaluable post-treatment specimens, when compared with paired pretreatment biopsies. Strikingly, significant post-treatment increases in CD3+ immune infiltration (P=0.0366) and CD4+FoxP3+ immune infiltration (P=0.0277) were observed in pCR tumors, with no significant difference in non-pCR tumors. CONCLUSIONS The different response to IO plus cCRT therapy in locally advanced G/GEJC patients and be explained by the difference in TME including the baseline CD56 dim+ immune infiltration, TLSs status and the reprogrammed immune infiltration induced by IO PLUS cCRT therapy. Further large population based studies are warranted to validate the response mechanism. Citation Format: Jia Wei, Qin Liu, Hui Chen, Xin Zhang, Feilong Zhao, Yao Fu, Ju Yang, Yue Wang, Shiqing Chen, Xiaochen Zhao, Yuezong Bai, Wenxian Guan, Baorui Liu. CD56 dim+ immune infiltration and reprogrammed TMEs associated with response to neoadjuvant anti-PD-1 immunotherapy plus concurrent chemoradiotherapy in locally advanced gastric or gastroesophageal junction adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6176.

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Huang, Yuanyuan, Hangbo Ye, Qingliang Yang, Lingli Zhang, Huihui Guo, Xiaolei Liu, Wenjun Li, et al. "Abstract 5820: An antibody drug conjugate platform based on novel camptothecin payloads with branch hydrophilic linkers and site-specific conjugation." Cancer Research 84, no. 6_Supplement (March 22, 2024): 5820. http://dx.doi.org/10.1158/1538-7445.am2024-5820.

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Abstract Antibody-drug conjugates (ADCs) have recently gained momentum as a therapeutic modality for the cell-specific delivery of small molecules beyond their originally-intended purpose of treating cancer. However, the selection of combinations of an optimum target, antibody, payload, linker as well conjugation, to achieve maximal therapeutic efficacy without excessive toxicity, still presents a significant challenge. Topoisomerase I (Topo I) inhibitors such as camptothecin (CPT) analogs represent the much success in ADC payload applications as two CPT analog-ADCs, trastuzumab deruxtecan (DS-8201a—Enhertu®) with Dxd payload and sacituzumab govitecan (TrodelvyTM) with SN38 payload have been approved and over 20 CPT analog-ADCs are in the clinical trials now. Topo I inhibitors trigger cell apoptosis through their specific binding at the DNA-topoisomerase interface, leading to the inhibition of DNA supercoiling and entanglement, resulting in DNA damage and cell death. This class of payloads in ADCs has demonstrated more wider therapeutic windows in clinical trials than regular antitubulin payloads, such as maytansine and MMAE, based ADCs. Here, we detail the discovery of CPT analogs, as payloads with a branch hydrophilic linker and site-specific conjugation for ADCs designed to have a widened therapeutic window compared with Dxd-GGFG linked ADCs. The CPT analogs based on the core structure of SN-38, wherein the hydrogen of C-11 was replaced with fluorine, and the hydroxyl group of C-10 was optionally replaced with an amino or a ether group. Many of the novel CPT analogs were at single to tens of pM of IC50 potency in vitro against several tested tumor cell lines, and some were more potent than Exatecan in the comparison tests. The ADCs constructed with branch hydrophilic linkers and the CrossConjuTM technology of chemically site-specific conjugation at Fab region of an antibody through C-10 position of the CPT payloads either with amide bond, either bond or carbamide bonds, or through C-20 position of the CPT payloads with carbamide or carbonate bonds, exhibited much better antitumor efficacy in vivo CDX tumor models, while having higher or similar MTDs in mice toxicity study in comparison with the ADC constructed with GGFG-Dxd, demonstrated wider therapeutic widows than that conjugated with GGFG-Dxd. Moreover, some of the constructed ADCs can overcomes in vitro- and in vivo-acquired resistance of commercial therapeutic drugs. Herein, we showcase our platform approach in CPT-ADC designs and constructions and can be thereby broadly applicable to construction of various CPT-ADCs for targeted treatment of cancers. Citation Format: Yuanyuan Huang, Hangbo Ye, Qingliang Yang, Lingli Zhang, Huihui Guo, Xiaolei Liu, Wenjun Li, Lu Bai, Junxiang Jia, Juan Wang, Xiangfei Kong, Jun Zheng, Yifang Xu, Gengxiang Zhao, Linyao Zhao, Xiang Cai, Ziyu Zhao, Hui Xia, Xia Zhou, You Zhou, Robert Y. Zhao. An antibody drug conjugate platform based on novel camptothecin payloads with branch hydrophilic linkers and site-specific conjugation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5820.

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Schmalzer, Sigrid. "Weimin Xiong;, Kedi Wang. He cheng yi ge dan bai zhi: Jie jing niu yi dao su de ren gong quan he cheng [Synthesize a protein: The story of total synthesis of crystalline insulin project in China]. (Zhongguo jin xian dai ke xue ji shu shi yan jiu cong shu.). 194 pp., figs., bibl., app., index. Jinan: Shandong jiao yu chu ban she [Shandong Education Press], 2005. $25 (paper)." Isis 99, no. 1 (March 2008): 231–32. http://dx.doi.org/10.1086/589404.

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Nazir, Aqsa, Saeme Motevalian, and Bilal El-Zahab. "Conductive Metal Organic Framework as Trapping Cathode Additive for High Performance Lithium-Sulfur Batteries." ECS Meeting Abstracts MA2023-01, no. 1 (August 28, 2023): 421. http://dx.doi.org/10.1149/ma2023-011421mtgabs.

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Lithium-Sulfur (Li-S) batteries with high capacity and energy density have arisen as one of the most promising secondary batteries. However, higher order lithium polysulfide (LiPSs) shuttling and insulating nature of sulfur cathode results in capacity degradation and premature failure of the cell [1]. Here for the first time, we have implemented conductive Cu metal-based Metal organic framework (Cu-MOF) as a Li-S battery cathode material. Cu-MOF cathode catalyst not only reduce the LiPSs shuttle effect but also increase the conductivity of Li-S battery cathode [2]. Here, Cu-MOF pore morphology will trap the polysulfides and further prevent LiPSs shuttling. In addition, the well-defined architecture of organic ligands of Cu-MOF also participate to explicate the involved surface-binding mechanisms of S and polysulfide products. Furthermore, Cu-MOF improve the diffusion rate of Li ions, shackling LiPSs, upsurging conduction of electrons/ions, and regulating the deposition of Li2S2/Li2S towards cathode side [3]. Furthermore, sulfur active material is well percolated inside the pores of conductive Cu-MOF which shows the long-cycling performance as shown in Figure 1. Benefiting from the unique fibrous, porous, interwoven structure, the conductive MOF@S-composite cathode demonstrates a high initial capacity of 1671 mAh g–1 at 0.05 C rate with a good coulombic efficiency of >95% and the outstanding capacity of 849 mAh g-1 cycles even after 200 cycles at the 0.5 C-rate with coulombic efficiency of 98.3%. It is believed that, the experimental findings and mechanistic understanding of Cu-MOF cathode in this work will open a new avenue for the further development of other conductive MOFs in the Li-S batteries. Figure 1: Cycling performance of S@Cu-MOF composite at 0.5 C-rate. References Mingyue Wang, Zhongchao Bai, Ting Yang, Chuanhao Nie, Xun Xu, Yunxiao Wang, Jian Yang, Shixue Dou, and Nana Wan."Advances in High Sulfur Loading Cathodes for Practical Lithium-Sulfur Batteries." Energy Mater, no.12 (2022): 2201585. Dan Luo, Chaojie Li, Yongguang Zhang, Qianyi Ma, Chuyin Ma, Yihang Nie, Matthew Li, Xuefei Weng, Rong Huang, Yan Zhao, Lingling Shui, Xin Wang, Zhongwei Chen. "Design of Quasi-MOF Nanospheres as a Dynamic Electrocatalyst toward Accelerated Sulfur Reduction Reaction for High-Performance Lithium–Sulfur Batteries." Mater, no.34 (2022): 210554. Jun Zhang, Ye Shi, Yu Ding, Lele Peng, Wenkui Zhang, Guihua Yu. "A Conductive Molecular Framework Derived Li2S/N,P-Codoped Carbon Cathode for Advanced Lithium–Sulfur Batteries." Energy Mater, no.7 (2017): 1602876. Figure 1

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Books on the topic "Bai jia xing"

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Jie, Li, ed. Bai jia xing. Ha'erbin Shi: Ha'erbin chu ban she, 2007.

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Yiheng, Mu, Cai Weihong, and Xiong Kan, eds. Bai jia xing. [Nanchang Shi: Jiangxi mei shu chu ban she, 1998.

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Hangxia, Su, ed. Bai jia xing. Hangzhou Shi: Zhejiang gu ji chu ban she, 2003.

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hong, Luo wei, and Liang hong li, eds. Bai jia xing. 2nd ed. Bei jing: Qi xiang chu ban she, 2006.

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Zhao, Lanhui. Bai jia xing. Kunming: Yunnan jiao yu chu ban she, 2009.

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Meiyu, Zheng, and Guo Biru, eds. Bai jia xing. Tainan Shi: Da qian wen hua chu ban shi ye gong si, 2000.

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bo, Shi yan, and Chen li ping. Bai jia xing. Tong liao: Nei meng gu shao nian er tong chu ban she, 2006.

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Hao, Li, ed. Bai jia xing xin zhu. Xi'an: Hua yue wen yi chu ban she, 1989.

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Zhengmiao, Ye, ed. Xin bian bai jia xing. Taibei Xian Xindian Shi: Zheng zhong shu ju gu fen you xian gong si, 2005.

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Hongyi, Gu, ed. Xin yi bai jia xing. Taibei Shi: San min shu ju, 2005.

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