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Journal articles on the topic 'Bakers asthma; allergic diseases'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

de los Reyes Jiménez, Marta, Antonie Lechner, Francesca Alessandrini, Sina Bohnacker, Sonja Schindela, Aurélien Trompette, Pascal Haimerl, et al. "An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products." Science Translational Medicine 12, no. 540 (April 22, 2020): eaay0605. http://dx.doi.org/10.1126/scitranslmed.aay0605.

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Eicosanoids are key mediators of type-2 inflammation, e.g., in allergy and asthma. Helminth products have been suggested as remedies against inflammatory diseases, but their effects on eicosanoids are unknown. Here, we show that larval products of the helminth Heligmosomoides polygyrus bakeri (HpbE), known to modulate type-2 responses, trigger a broad anti-inflammatory eicosanoid shift by suppressing the 5-lipoxygenase pathway, but inducing the cyclooxygenase (COX) pathway. In human macrophages and granulocytes, the HpbE-driven induction of the COX pathway resulted in the production of anti-inflammatory mediators [e.g., prostaglandin E2 (PGE2) and IL-10] and suppressed chemotaxis. HpbE also abrogated the chemotaxis of granulocytes from patients suffering from aspirin-exacerbated respiratory disease (AERD), a severe type-2 inflammatory condition. Intranasal treatment with HpbE extract attenuated allergic airway inflammation in mice, and intranasal transfer of HpbE-conditioned macrophages led to reduced airway eosinophilia in a COX/PGE2-dependent fashion. The induction of regulatory mediators in macrophages depended on p38 mitogen-activated protein kinase (MAPK), hypoxia-inducible factor-1α (HIF-1α), and Hpb glutamate dehydrogenase (GDH), which we identify as a major immunoregulatory protein in HpbE. Hpb GDH activity was required for anti-inflammatory effects of HpbE in macrophages, and local administration of recombinant Hpb GDH to the airways abrogated allergic airway inflammation in mice. Thus, a metabolic enzyme present in helminth larvae can suppress type-2 inflammation by inducing an anti-inflammatory eicosanoid switch, which has important implications for the therapy of allergy and asthma.

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2

Ade, Serge, Mênonli Adjobimey, Gildas Agodokpessi, Marie Sylvie Kouassi, Fabien A. Gounongbe, Ibrahim Cisse, and Spero H. R. Hounkpatin. "Asthma Symptoms in Bakeries at Parakou, Benin." Pulmonary Medicine 2020 (January 30, 2020): 1–6. http://dx.doi.org/10.1155/2020/3767382.

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Background and Objectives. There is a dearth of information on asthma among bakers in low-income settings. The objectives of this study were to determine (i) the prevalence of asthma symptoms, (ii) factors associated with probable occupational asthma (OA), and (iii) work habits that might lead to a dusty workplace environment, Parakou, Benin. Materials and Methods. This was a mixed methods (cross-sectional quantitative and qualitative) study carried out between March and September 2018. Results. Of 210 employees/apprentices in 26 bakeries, 190 (91.48%) were included in the study: median age was 25.50 (IQR=22−32) years, 157 (82.63%) were aged <40 years, and the male-to-female ratio was 26.14. Of these, 111 (58.42%) worked in a salted bread and 79 (41.58%) in a sweet bread bakery. An asthma history was reported by 3.68%. Symptoms consistent with asthma, work-related asthma, OA, and work-aggravated asthma were found in 13.68%, 12.63%, 10%, and 2.63%, respectively. Asthma confirmation was obtained in 15.79% of bakers with probable OA and in 23.08% of all bakers with suspected asthma. A history of allergic rhinoconjunctivitis was associated with probable OA (aOR=106; 95%CI=17.79−2093; p<0.001). Of the 24 bakers with probable work-related asthma, 3 (12.50%) were prescribed a short-acting beta2-agonist and 2 (8.33%) an inhaled corticosteroid. No worker had had a systematically planned annual medical visit; some habits at work were identified as leading to flour and dust suspension at the workplace. Conclusion. Clinical manifestations of OA were common among bakers in Parakou and were associated with allergic rhinoconjunctivitis. There is a need to improve technical preventive measures and treatment, as well as to institute systematic medical visits for these workers.

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3

Pawankar, Ruby, Giorgio W. Canonica, Stephen T. Holgate, and Richard F. Lockey. "Allergic diseases and asthma." Current Opinion in Allergy and Clinical Immunology 12, no. 1 (February 2012): 39–41. http://dx.doi.org/10.1097/aci.0b013e32834ec13b.

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4

FRANKEN, J., and W. KONIG. "251 Analysis of allergic rye and wheat flour components in bakers' asthma disease." Journal of Allergy and Clinical Immunology 87, no. 1 (January 1991): 201. http://dx.doi.org/10.1016/0091-6749(91)91534-z.

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5

Gnaiger, Jutta. "Allergic asthma." British Homeopathic Journal 78, no. 03 (July 1990): 135–37. http://dx.doi.org/10.1016/s0007-0785(05)80331-x.

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AbstractSuccessful treatment with a homœopathic drug may be considered scientific proof. Every cure verifies the hypothesis established in selecting the indicated drug for a particular patient according to the law of similars, for the drug does not act unless it matches the complete range of symptoms presented by the patient in question, covering aetiology, mental symptoms, constitution, the type of disorder involved and local symptoms.Two patients, each with a long history of allergic asthma, are presented. Sepia proved effective, with both patients practically symptom-free for two years. The drug picture of Sepia is discussed with regard to both aetiology and constitution, as are other current views concerning the causes of allergic diseases of the respiratory tract. Noteworthy aspects are suppressed infectious conditions, sycosis (lithaemic and rheumatic diathesis combined) and lack of reactivity.

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6

Leonardi, Salvatore, Giuseppe Marchese, Gian Luigi Marseglia, and Mario La Rosa. "Montelukast in allergic diseases beyond asthma." Allergy and Asthma Proceedings 28, no. 3 (May 1, 2007): 287–91. http://dx.doi.org/10.2500/aap.2007.28.2955.

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7

Peebles, R. Stokes. "Prostaglandins in asthma and allergic diseases." Pharmacology & Therapeutics 193 (January 2019): 1–19. http://dx.doi.org/10.1016/j.pharmthera.2018.08.001.

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8

Pali-Schöll, Isabella, Cassim Motala, and Erika Jensen-Jarolim. "Asthma and Allergic Diseases in Pregnancy." World Allergy Organization Journal 2, no. 3 (2009): 26–36. http://dx.doi.org/10.1186/1939-4551-2-3-26.

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9

Pali-Schöll, Isabella, Cassim Motala, and Erika Jensen-Jarolim. "Asthma and Allergic Diseases in Pregnancy." World Allergy Organization Journal 2, no. 3 (March 2009): 26–36. http://dx.doi.org/10.1097/wox.0b013e31819b0a86.

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10

TePas, Elizabeth C., and Dale T. Umetsu. "Immunotherapy of asthma and allergic diseases." Current Opinion in Pediatrics 12, no. 6 (December 2000): 574–78. http://dx.doi.org/10.1097/00008480-200012000-00011.

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11

Karakoca, Y., A. U. Demir, G. Kisacik, A. F. Kalyoncu, and S. Findik. "Speleotherapy in asthma and allergic diseases." Clinical Experimental Allergy 25, no. 7 (July 1995): 666–69. http://dx.doi.org/10.1111/j.1365-2222.1995.tb01115.x.

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12

Shamji, Mohamed H., and Robert J. Boyle. "Biomarkers in asthma and allergic diseases." Clinical & Experimental Allergy 51, no. 8 (August 2021): 982–84. http://dx.doi.org/10.1111/cea.13988.

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13

Kartal, Ozgur, Ahmet Caliskaner, and Osman Sener. "Acupuncture Treatment in Asthma and Allergic Diseases." TAF Preventive Medicine Bulletin 10, no. 1 (2011): 107. http://dx.doi.org/10.5455/pmb.20110107094637.

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14

Chini, L., E. Monteferrario, S. Graziani, and V. Moschese. "Novel treatments of asthma and allergic diseases." Paediatric Respiratory Reviews 15, no. 4 (December 2014): 355–62. http://dx.doi.org/10.1016/j.prrv.2013.10.007.

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15

Bonini, S. "E02 Epidemiology of asthma and allergic diseases." Journal of Crohn's and Colitis Supplements 4, no. 1 (April 2010): 2. http://dx.doi.org/10.1016/s1873-9954(10)70006-9.

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16

Wardlaw, A. J., C. Brightling, R. Green, G. Woltmann, and I. Pavord. "Eosinophils in asthma and other allergic diseases." British Medical Bulletin 56, no. 4 (January 1, 2000): 985–1003. http://dx.doi.org/10.1258/0007142001903490.

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17

Stirling, R. G., and K. F. Chung. "Future treatments of allergic diseases and asthma." British Medical Bulletin 56, no. 4 (January 1, 2000): 1037–53. http://dx.doi.org/10.1258/0007142001903526.

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18

Laprise, Catherine, and Emmanuelle Bouzigon. "The genetics of asthma and allergic diseases." Current Opinion in Allergy and Clinical Immunology 13, no. 5 (October 2013): 461–62. http://dx.doi.org/10.1097/aci.0b013e328364ebc3.

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19

Fitzpatrick, Anne M. "Biomarkers of asthma and allergic airway diseases." Annals of Allergy, Asthma & Immunology 115, no. 5 (November 2015): 335–40. http://dx.doi.org/10.1016/j.anai.2015.09.003.

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20

Fernandes, Silvia de Souza Campos, Cláudia Ribeiro de Andrade, Cristina Gonçalves Alvim, Paulo Augusto Moreira Camargos, and Cássio da Cunha Ibiapina. "Epidemiological trends of allergic diseases in adolescents." Jornal Brasileiro de Pneumologia 43, no. 5 (September 2017): 368–72. http://dx.doi.org/10.1590/s1806-37562016000000255.

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ABSTRACT Objective: To assess the prevalences of asthma, allergic rhinitis, and allergic rhinoconjunctivitis in adolescents in the city of Belo Horizonte, Brazil, in 2012 by administering the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, as well as to compare the observed prevalences with those found in studies performed 10 years earlier and employing the same methodology used here. Methods: This was a cross-sectional study conducted between May and December of 2012 and involving adolescents in the 13- to 14-year age bracket. Participants were randomly selected from among adolescents studying at public schools in Belo Horizonte and completed the ISAAC questionnaire. Proportions were calculated in order to assess the prevalences of asthma, allergic rhinitis, and allergic rhinoconjunctivitis in the sample as a whole, and the chi-square goodness-of-fit test was used in order to compare the prevalences observed in 2012 with those found in 2002. Results: The prevalences of symptoms of asthma, allergic rhinitis, and allergic rhinoconjunctivitis in 2012 were 19.8%, 35.3%, and 16.3%, respectively, being significantly higher than those found in 2002 (asthma, p = 0.006; allergic rhinitis, p < 0.01; and allergic rhinoconjunctivitis, p = 0.002). Conclusions: The prevalences of asthma, allergic rhinitis, and allergic rhinoconjunctivitis among adolescents in 2012 were found to be high, having increased in comparison with those found 10 years earlier, despite efforts in prevention, diagnosis, and treatment.

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21

Milanovic, Borko, Gordana Vijatov-Djuric, Mirjana Stojsic, Aleksandra Milutinovic, and Jelena Stojcevic-Maletic. "Comparison of serum interleukin-33 levels in children with allergic respiratory diseases." Medical review 73, no. 3-4 (2020): 88–93. http://dx.doi.org/10.2298/mpns2004088m.

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Introduction. Recent studies point to the importance of interleukin-33 in the pathogenesis of allergic respiratory diseases. The relationship of interleukin-33 and certain allergic respiratory diseases as well as their characteristics is not fully elucidated. The basic aim of this research was to determine interleukin-33 serum levels in children with allergic asthma and allergic rhinitis, as well as to examine the relationship between obtained interleukin-33 levels and individual clinical characteristics of these patients. Material and Methods. Serum interleukin- 33 levels were measured in a total of 91 children. The study group included 39 children with both allergic asthma and allergic rhinitis, and also 22 children with allergic asthma without allergic rhinitis. The control group included 30 healthy children. Results. Serum levels of interleukin-33 in children with both allergic asthma and allergic rhinitis were significantly higher compared to those in children with allergic asthma only (?2 = 7.01; p = 0.008; p < 0.01). Both groups of patients had significantly higher interleukin-33 serum levels compared to healthy children (?2 = 7.01; p = 0.008; p < 0.01). The correlation between serum interleukin-33 levels and allergic asthma severity was statistically significant (rs = 0.289; p = 0.024; p < 0.05). Conclusion. Serum levels of interleukin-33 were significantly higher in children with allergic respiratory diseases compared to healthy examinees. Significantly higher levels of serum interleukin-33 levels were found in children with both allergic asthma and allergic rhinitis, compared to children with allergic asthma only. Patients with higher interleukin- 33 serum levels also had a more severe type of allergic asthma.

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22

Hauswald, Bettina, Mandy Cuevas, Jürgen Boxberger, and Thomas Zahnert. "Safe and effective hyposensitization in bakers suffering from year-round allergic rhinoconjunctivitis and allergic bronchial asthma caused by flour dust allergy." Allergo Journal International 27, no. 2 (March 2018): 43–48. http://dx.doi.org/10.1007/s40629-018-0052-4.

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23

DUBUSKE, L. "Introduction: Risk management in asthma and allergic diseases." Journal of Allergy and Clinical Immunology 98, no. 6 (December 1996): S289—S290. http://dx.doi.org/10.1016/s0091-6749(96)70055-6.

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24

Du Buske, Lawrence M. "Introduction: Risk management in asthma and allergic diseases." Journal of Allergy and Clinical Immunology 98, no. 6 (December 1996): S289—S290. http://dx.doi.org/10.1016/s0091-6749(96)80113-8.

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25

Bener, Abdulbari, and Mohammad S. Ehlayel. "Does prolonged breastfeeding prevent asthma and allergic diseases?" World Allergy Organization Journal &NA; (November 2007): S321. http://dx.doi.org/10.1097/01.wox.0000301543.66396.dd.

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26

H ansel. "Asthma and Allergic Diseases: physiology, immunopharmacology and treatment." Clinical & Experimental Allergy 29, no. 1 (January 1999): 135. http://dx.doi.org/10.1046/j.1365-2222.1999.00bka.x.

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27

Cookson, William. "Genetics and genomics of asthma and allergic diseases." Immunological Reviews 190, no. 1 (December 2002): 195–206. http://dx.doi.org/10.1034/j.1600-065x.2002.19015.x.

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28

Lin, Ting-Yu, Narayanan Venkatesan, Bassam Mahboub, and Qutayba Hamid. "Involvement of lymphocytes in asthma and allergic diseases." Current Opinion in Allergy and Clinical Immunology 13, no. 5 (October 2013): 500–506. http://dx.doi.org/10.1097/aci.0b013e328364ea3a.

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29

Kling, Jim. "IL-4 may unlock asthma and allergic diseases." Nature Biotechnology 15, no. 4 (April 1997): 316–17. http://dx.doi.org/10.1038/nbt0497-316.

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30

Kucuksezer, Umut Can, Cevdet Ozdemir, Mubeccel Akdis, and Cezmi A. Akdis. "Precision/Personalized Medicine in Allergic Diseases and Asthma." Archivum Immunologiae et Therapiae Experimentalis 66, no. 6 (September 24, 2018): 431–42. http://dx.doi.org/10.1007/s00005-018-0526-6.

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31

Shkolnikov, V. S., L. А. Klimas, D. G. Smolko, I. M. Makarchuk, and S. V. Koliadenko. "Signs of palmar dermatoglyphics as markers of atopic diseases." Reports of Morphology 25, no. 1 (February 28, 2019): 39–44. http://dx.doi.org/10.31393/morphology-journal-2019-25(1)-06.

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The family character of atopic conditions, confirmed by many studies, has become the basis for the use of the method of dermatoglyphics to clarify the genetic nature of the “atopic march”. The purpose of the study was to identify differences in the features of palmar dermatoglyphics between patients with atopic dermatitis, allergic rhinitis and bronchial asthma. Primary indexes of palmar dermatoglyphics of young men and young women patients with atopic dermatitis, allergic rhinitis and bronchial asthma were taken from the data bank of the research center of National Pirogov Memorial Medical University, Vinnytsya. According to the method of Cummins H. and Midlo Ch. dermatoglyphic study of 320 young men and young women with allergic rhinitis (n = 69), bronchial asthma (n = 108) and atopic dermatitis (n = 143) was performed. Quantitative indices of palmar dermatoglyphics were subject to analysis. The results obtained were processed using the Statistica 6.1 license package using non-parametric methods. It is established that the differences of quantitative indices of palmar dermatoglyphics between young men / young women with atopic dermatitis and allergic rhinitis cover 50.0% / 66.67%; among patients with atopic dermatitis and bronchial asthma – 38.89% / 33.33%; among patients with allergic rhinitis and bronchial asthma – 22.22% / 55.56% respectively. Thus, in young men, the marker potential for signs of palmar dermatoglyphics in the prognosis for the development of bronchial asthma in the presence of allergic rhinitis (22.22%) or atopic dermatitis (38.89%) are insignificant compared with the prognosis for the development of allergic rhinitis in the presence of atopic dermatitis (50.0%). In young women, the marker features of palmar dermatoglyphics in the prognosis for the development of bronchial asthma in the presence of atopic dermatitis are insignificant (33.33%) compared with the prognosis for the development of bronchial asthma in the presence of allergic rhinitis (55.56%) and the prognosis for the development of allergic rhinitis (66.67%).

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32

Kurbacheva, O. M., and M. A. Galitskaya. "The place of Omalizumab in the treatment of allergic diseases." Medical Council, no. 15 (December 8, 2019): 38–49. http://dx.doi.org/10.21518/2079-701x-2019-15-38-49.

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The article describes a modern approach to the use of anti-IgE therapy for allergic bronchial asthma and conditions associated with this disease. The humanized monoclonal anti-IgE antibody, Omalizumab (Xolar®), is a promising treatment for allergic diseases mediated by IgE. Much evidence has been obtained of the effectiveness of Omalizumab in allergic bronchial asthma and chronic spontaneous (idiopathic) urticaria, on the basis of which global meta-analyzes have been carried out confirming the effectiveness and safety of this therapeutic strategy. Recent scientific articles actively discuss the possibility of expanding indications for the medical use of Omalizumab. Clinical studies have been published on the efficacy and safety of Omalizumab for allergic rhinitis, allergic keratoconjunctivitis, chronic rhinosinusitis, nasal polyps, chronic idiopathic urticaria, food allergies, allergen-specific immunotherapy, atopic dermatitis, allergic bronchopulmonary aspergillosis – in cases of comorbidity with asthma. The clinical effect of Omalizumab in patients with allergic bronchial asthma is the most studied and proven. Currently, a number of clinical studies evaluate the long-term results of prolonged use of Omalizumab or the condition after its cancellation in patients with allergic bronchial asthma and various comorbidity.

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Nakagome, Kazuyuki, and Makoto Nagata. "Role of Allergen Immunotherapy in Asthma Treatment and Asthma Development." Allergies 1, no. 1 (December 9, 2020): 33–45. http://dx.doi.org/10.3390/allergies1010003.

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Allergen immunotherapy may modify the natural course of allergic diseases and induce remission. It includes subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT). For asthma, allergen immunotherapy using house dust mite (HDM) improves clinical symptoms and airway hyperresponsiveness and decreases drug requirements. Furthermore, it has been suggested that allergen immunotherapy also has the following effects: (1) the effect can be maintained for more than a year even if the treatment is terminated, (2) the remission rate of childhood asthma can be increased, (3) new allergen sensitization can be suppressed, and (4) asthma development can be prevented if allergen immunotherapy was performed in the case of pollinosis. Allergen immunotherapy differs from conventional drug therapy, in particular the effect of modifying the natural course of allergic diseases and the effect of controlling complicated allergic diseases such as rhinoconjunctivitis. The general indication for HDM-SCIT in asthma is HDM-sensitized atopic asthma with mild-to-moderate disease and normal respiratory function. HDM allergens should be involved in the pathogenesis of asthma, and a duration of illness of less than 10 years is desirable. HDM-SLIT is available for allergic rhinitis but not for asthma in Japan. However, as the efficacy of SLIT for asthma has been fully proven internationally, SLIT is also applied in asthmatics with complicated allergic rhinitis in Japan.

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Wüthrich, Brunello. "Epidemiology of allergic diseases in Switzerland." Therapeutische Umschau 58, no. 5 (May 1, 2001): 253–58. http://dx.doi.org/10.1024/0040-5930.58.5.253.

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In dieser Übersicht werden die epidemiologischen Daten über das Vorkommen allergischer Erkrankungen in der Schweiz zusammengefasst. Die Schweizer Studie über Luftverschmutzung und Atemwegserkrankungen bei Erwachsenen (SAPALDIA) erfasste in den Jahren 1991 bis 1993 9651 zufällig ausgewählte Probanden (18- bis 60-jährige) in acht Schweizer Regionen (Stadt-, Land- und Berggebiete). Bei 8357 lagen vollständige Allergieteste vor. 32,3% erwiesen sich als Atopiker (positive Prickteste und/oder positiver Phadiatop). (Phadiatop ist ein In-vitro-Screening-Test für inhalative Sensibilisierungen.) 12,7% waren gegen Graspollen, 8,9% gegen Hausstaubmilben, 7,9% gegen Birkenpollen und 3,8% gegen Katzenepithelien sensibilisiert. 11,1% litten an einer allergologisch diagnostizierten aktuellen Rhinitis pollinosa, 6,8% an einem vom Arzt diagnostizierten Asthma bronchiale (kumulative Prävalenz). Die Pollinosis war häufiger in den Städten (z.B. in Basel 18,0%) als in den ländlichen Regionen (z.B. in Payerne 6,4%). Die geometrischen IgE-Mittelwerte der SAPALDIA-Stichprobe betrugen 31,3 kU/l (30.3.–32.3); Raucher wiesen höhere Serum-IgE-Spiegel (39,7 kU/l) auf. Die niedrigsten IgE-Werte zeigten Phadiatop-negative Nicht-Raucher (15,5 kU/l) (p < 0.001). Bei Phadiatop-positiven Probanden lagen die mittleren IgE-Serumspiegel bei 104,3 kU/l. Passivraucher hatten im Vergleich zu nicht-exponierten Nicht-Rauchern ein erhöhtes Risiko für pfeifende Atmung (OR = 1,94), Atemnot (1,45), Asthma (1,39) und chronische Bronchitis (1,50). Gemäß der Schweizer Studie über das Vorkommen von Allergien bei Schulkindern (SCARPOL) (6/7-, 9/11-, 13/15-Jährige) leiden 17,0% der 15-jährigen Schüler an Heuschnupfen, Knaben mit 19,4% häufiger als Mädchen mit 14,8%. Ein vom Arzt diagnostiziertes Asthma bronchiale (jemals) kam mit etwa 9,0% in allen Altersgruppen gleich häufig vor. Die Prävalenz von atopischer Dermatitis betrug durchschnittlich 13% mit einer aktuellen Prävalenz von 8%, ohne signifikante Unterschiede innerhalb der Altersklassen. Ihr Vorkommen ist jedoch stark von sozio-ökonomischen Faktoren und einer Katzenhaltung abhängig. Bauernkinder leiden signifikant seltener an Heuschnupfen und Asthma als gleichaltrige Kinder ohne Tätigkeit in der Landwirtschaft. Sowohl die SAPALDIA- als auch die SCARPOL-Studie belegen die hohe Prävalenz von atopischen Sensibilisierungen und atopischen Erkrankungen in der Schweiz und die gesundheitlichen Auswirkungen der Luftverschmutzung und des «western life-style» auf ihr Vorkommen. Die Beobachtungen an Bauernkindern hingegen lassen den Schluss zu, dass ein traditioneller bäuerlicher Lebensstil ein Schutzfaktor vor Allergien bedeuten könnte.

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35

Kang, Sung-Yoon, Min-Suk Yang, Sang Min Lee, and Sang Pyo Lee. "Allergen-Specific Immunotherapy Against Allergic Respiratory Diseases." Korean Journal of Medicine 95, no. 6 (December 1, 2020): 370–76. http://dx.doi.org/10.3904/kjm.2020.95.6.370.

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Allergen-specific immunotherapy (AIT) can alter the natural course of an allergic disease. It is widely held that the efficacy of a given therapeutic modality should be proven by well-designed double-blind placebo-controlled randomized clinical trials and meta-analyses. In this article, the therapeutic efficacy of AIT for allergic respiratory diseases, such as allergic rhinitis and asthma, is reviewed. In addition, potential clinical and experimental predictors of the treatment response are reviewed for AITs requiring long-term treatment, and for some allergic rhinitis and asthma patients who show no response to AIT.

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36

Minkailov, E. K., K. M. O. Minkailov, R. M. Abueva, and A. B. Strok. "Prevalence of allergic diseases in adolescents." PULMONOLOGIYA, no. 1 (February 28, 2005): 77–80. http://dx.doi.org/10.18093/0869-0189-2005-0-1-77-80.

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A screening search of 495 adolescents found bronchial asthma in 7.45 % and allergic diseases (AD) in general in 44.8 %. Most frequent AD were allergic rhinitis (16.6 %) and skin lesions (15.1 %). AD patients considerably more often nave respiratory signs (cough, breathlessness, sputum, wheezing), bronchial obstruction (22.7 % vs. 6.6 %, P < 0.05) and bronchial hyperresponsiveness (34.3 % vs. 5.7 %, P < 0.05) as compared to controls.

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37

Fazel, Nasrin, Asghar Kazemzadeh, Mojtaba Abdizadeh, Erika Jensem-Jarolim, Shohreh Shahrouyan, and Sina Shahrooyan. "Prevalence of asthma and other allergic diseases in pregnant women." Acta Facultatis Medicae Naissensis 38, no. 2 (2021): 125–34. http://dx.doi.org/10.5937/afmnai38-29256.

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Asthma and allergic disorders can affect the outcome of pregnancy. Asthma and allergies are common comorbidities during pregnancy and exacerbations are the major clinical problem. Results are not consistent between studies .Therefore, the aim of this study was to determine the frequency of asthma and allergic disease during pregnancy. This prospective cohort study was carried out at the antenatal clinic of Mobini Hospital in Iran. Overall, 1,603 women were enrolled prior to the 24th week of pregnancy. All participants were interviewed for allergy disease, allergic trigger factors and severity of asthma. Also, asthma control was categorized as per GINA guidelines. The diagnosis of asthma was based on symptoms, pulmonologist diagnosis, and spirometry assessment. The results were analyzed using SPSS version 20 and T-tests and Chi-square test. The prevalence of asthma during pregnancy was 2.1% among the participants. The most common allergens in asthmatic group were pollen, stress, and climate. There was a significant relationship between age, education and place of living in asthmatic and non-asthmatic group, p = 0.003, p=0.05, p=0.008, respectively. There was a significant relationship between asthma symptoms among the two groups (p=0.001). In addition, a significant relationship was found between asthma and other allergic diseases including eczema, allergy, rhinitis, and wheeze in asthmatic women, with a significant relationship between wheeze and coughing and allergy. Exposure of the pregnant women to high levels of allergens, like pollen, and allergic diseases resulted in an increased risk of pregnancy outcomes. Careful management of these diseases should prevent most of the serious complications

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Pasha, M. Asghar, Gargi Patel, Russell Hopp, and Qi Yang. "Role of innate lymphoid cells in allergic diseases." Allergy and Asthma Proceedings 40, no. 3 (May 1, 2019): 138–45. http://dx.doi.org/10.2500/aap.2019.40.4217.

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Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.

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Meng, Jian-Feng, and Lanny J. Rosenwasser. "Unraveling the Genetic Basis of Asthma and Allergic Diseases." Allergy, Asthma and Immunology Research 2, no. 4 (2010): 215. http://dx.doi.org/10.4168/aair.2010.2.4.215.

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Bousquet, Jean, Hans Yssel, and Pascal Demoly. "Prospects for a Vaccine in Allergic Diseases and Asthma." BioDrugs 13, no. 1 (January 2000): 61–75. http://dx.doi.org/10.2165/00063030-200013010-00006.

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Fishman, Suzanne, Kathryn Hobbs, and Larry Borish. "MOLECULAR BIOLOGY OF CYTOKINES IN ALLERGIC DISEASES AND ASTHMA." Immunology and Allergy Clinics of North America 16, no. 3 (August 1996): 613–42. http://dx.doi.org/10.1016/s0889-8561(05)70263-0.

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Lotfi, Ramin, Alireza Rezaiemanesh, Seyed Hamidreza Mortazavi, Ali Gorgin Karaji, and Farhad Salari. "Immunoresolvents in asthma and allergic diseases: Review and update." Journal of Cellular Physiology 234, no. 6 (November 29, 2018): 8579–96. http://dx.doi.org/10.1002/jcp.27836.

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Julia, Valerie, Laurence Macia, and David Dombrowicz. "The impact of diet on asthma and allergic diseases." Nature Reviews Immunology 15, no. 5 (April 24, 2015): 308–22. http://dx.doi.org/10.1038/nri3830.

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KALYONCU, A. F. "Prevalence of asthma and allergic diseases related with emigration." Australian and New Zealand Journal of Medicine 25, no. 2 (April 1995): 177. http://dx.doi.org/10.1111/j.1445-5994.1995.tb02837.x.

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Pali-Schöll, Isabella, Jennifer Namazy, and Erika Jensen-Jarolim. "Allergic diseases and asthma in pregnancy, a secondary publication." World Allergy Organization Journal 10 (2017): 10. http://dx.doi.org/10.1186/s40413-017-0141-8.

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Searing, Daniel A., and Donald Y. M. Leung. "Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases." Immunology and Allergy Clinics of North America 30, no. 3 (August 2010): 397–409. http://dx.doi.org/10.1016/j.iac.2010.05.005.

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Navinés-Ferrer, Arnau, Eva Serrano-Candelas, Gustavo-J. Molina-Molina, and Margarita Martín. "IgE-Related Chronic Diseases and Anti-IgE-Based Treatments." Journal of Immunology Research 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/8163803.

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IgE is an immunoglobulin that plays a central role in acute allergic reactions and chronic inflammatory allergic diseases. The development of a drug able to neutralize this antibody represents a breakthrough in the treatment of inflammatory pathologies with a probable allergic basis. This review focuses on IgE-related chronic diseases, such as allergic asthma and chronic urticaria (CU), and on the role of the anti-IgE monoclonal antibody, omalizumab, in their treatment. We also assess the off-label use of omalizumab for other pathologies associated with IgE and report the latest findings concerning this drug and other new related drugs. To date, omalizumab has only been approved for severe allergic asthma and unresponsive chronic urticaria treatments. In allergic asthma, omalizumab has demonstrated its efficacy in reducing the dose of inhaled corticosteroids required by patients, decreasing the number of asthma exacerbations, and limiting the effect on airway remodeling. In CU, omalizumab treatment rapidly improves symptoms and in some cases achieves complete disease remission. In systemic mastocytosis, omalizumab also improves symptoms and its prophylactic use to prevent anaphylactic reactions has also been discussed. In other pathologies such as atopic dermatitis, food allergy, allergic rhinitis, nasal polyposis, and keratoconjunctivitis, omalizumab significantly improves clinical manifestations. Omalizumab acts in two ways: by sequestering free IgE and by accelerating the dissociation of the IgE-Fcεreceptor I complex.

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Park, Jeong-Hui, Eunhye Yoo, Myong-Won Seo, Hyun Chul Jung, and Jung-Min Lee. "Association between Physical Activity and Respiratory Diseases in Adolescents: An Age- and Gender-Matched Study." International Journal of Environmental Research and Public Health 18, no. 4 (February 3, 2021): 1397. http://dx.doi.org/10.3390/ijerph18041397.

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The purpose of the present cross-sectional study was to examine the impacts of allergic respiratory diseases on physical activity (PA), sedentary behaviors (SB), and body mass index (BMI) by matching age and gender with those adolescents without allergic respiratory diseases. This present study analyzed data from the 2019 Korea Youth Risk Behavior Web-based Survey (KYRBWS). Among 57,303 Korean adolescents who responded to the survey, the study divided adolescents into three different groups (i.e., general, asthma, and allergic rhinitis group). Asthma and allergic rhinitis groups included adolescents who checked on asthma- or allergic rhinitis-related questions as ‘yes’ (n = 259, n = 259), but the general group responded to any diseases-related question as ‘no’ (n = 259). The age and gender of participants among the three groups were matched. The results showed weight and BMI were significantly higher in asthma and allergic rhinitis groups compared to the general group (p < 0.001, p < 0.001). Furthermore, age, asthma, and allergic rhinitis were observed to be strong risk factors for predicting obesity in adolescents (BMI, >25.0 kg/m2). In addition, this study found allergic respiratory diseases strong impacts on BMI levels because adolescents with ongoing asthma, or allergic rhinitis symptoms were more likely to have the inevitability of further weight gain compared to the general adolescents. Therefore, not only national interest in adolescents with allergic respiratory disease is essential, but PA should be encouraged to prevent and alleviate these diseases due to obesity.

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Domuz, Sanela, Adrijana Domuz, and Slobodanka Petrovic. "Prevalence and comorbidity of asthma, allergic rhinitis and eczema among school children in Republic of Srpska: A cross-sectional study." Srpski arhiv za celokupno lekarstvo 145, no. 1-2 (2017): 9–13. http://dx.doi.org/10.2298/sarh151217001d.

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Introduction/Objective. The incidence of comorbidity of asthma and allergic rhinitis was one of the reasons for changing guidelines for the treatment of asthma and allergic rhinitis. The World Health Organization and Allergic Rhinitis and its Impact on Asthma group proposed the new diagnostic and therapeutic concept ??one airway, one disease.? Further, the presence of allergic rhinitis in children with asthma contributes significantly to low control of asthma; also, the treatment of allergic rhinitis in children with asthma has positive effects in terms of reducing the severity of asthma symptoms. The aim of this study was to determine the prevalence of allergic diseases among children in the Republic of Srpska, as well as to determine whether allergic rhinitis and eczema are more common in children with asthma. Methods. Our study was conducted as a cross-sectional study and included 3,000 children aged six to 15 years from 13 primary schools in the Republic of Srpska. The final data processing included 1,975 correctly completed questionnaires. Results. The prevalence of wheezing in the previous 12 months was 7.9%, of allergic rhinitis 12.7%, and of eczema 5%. Asthma was diagnosed by a doctor in 3.5% of the children, allergic rhinitis in 19.2%, and eczema was diagnosed in 14.5% of the children. Conclusion. Children with asthma had statistically significant higher prevalence of other alergic diseases compared to general population. Also, children with mild asthma had statistically significant risk to be undiagnosed. Undiagnosed asthma in comorbidity with other allergic diseases leads to poor asthma control in children.

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Bedolla-Barajas, Martín, Norma Angélica Pulido-Guillén, Bolívar Vivar-Aburto, Jaime Morales-Romero, José Raúl Ortiz-Peregrina, and Martín Robles-Figueroa. "Is suicidal ideation associated with allergic asthma and allergic rhinitis?" Jornal Brasileiro de Pneumologia 44, no. 1 (February 2018): 31–35. http://dx.doi.org/10.1590/s1806-37562017000000129.

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ABSTRACT Objective: To investigate whether there is an association between suicidal ideation (SI) and allergic diseases in adults. Methods: This was a comparative cross-sectional study involving individuals ranging from 20 to 50 years of age recruited from a university hospital in the city of Guadalajara, Mexico. We included patients with a confirmed diagnosis of allergic asthma, those with a confirmed diagnosis of allergic rhinitis, and healthy controls. All subjects completed the Beck Depression Inventory-II (BDI-II), which includes an item that evaluates the presence of suicidal thoughts or desires within the last two weeks, in order to identify SI. Results: The sample comprised 115 patients with allergic asthma, 111 patients with allergic rhinitis, and 96 healthy controls. The number of individuals identified with SI in the three groups were, respectively, 17 (14.8%), 13 (11.7%), and 8 (8.3%). Regarding the presence of SI, no statistically significant association was found in the allergic asthma group (OR = 1.98; 95% CI: 0.78-4.64; p = 0.154) or in the allergic rhinitis group (OR = 1.46; 95% CI: 0.58-3.68; p = 0.424) when they were compared with the control group. However, the presence of depression was associated with SI in the three groups: allergic asthma (OR = 12.36; 95% CI: 2.67-57.15; p = 0.001); allergic rhinitis (OR = 6.20; 95% CI: 1.66-23.14; p = 0.006); and control (OR = 21.0; 95% CI: 3.75-117.36; p < 0,001). Conclusions: In comparison with the control group, no association was found between SI and the groups with allergic diseases. In contrast, there was association between SI and depression in the three groups.

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