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Journal articles on the topic 'BalB-C strain mice'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Timothy, L. M., and J. M. Behnke. "Necator americanus in inbred mice: a re-evaluation of primary infection kinetics." Parasitology 107, no. 4 (1993): 425–31. http://dx.doi.org/10.1017/s0031182000067780.

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SUMMARYThe course of a primary Necator americanus infection was studied in the lungs and small intestines of syngeneic mice. Following percutaneous infection no difference in initial larval establishment in the lungs was found between male BALB/c, NIH or B10.G mice. However, significant differences in the subsequent kinetics of infection were demonstrated between the BALB/c and NIH strains. Lung worm burdens declined more slowly in NIH mice than in BALB/c strain. Surprisingly, however, a greater proportion of larvae remaining in the lungs of BALB/c mice, 9 days p.i., were trapped than in NIH m

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2

Quan, Natalie, Lacey R. Harris, Ritika Halder, et al. "Differential sensitivity of inbred mouse strains to ovarian damage in response to low-dose total body irradiation†." Biology of Reproduction 102, no. 1 (2019): 133–44. http://dx.doi.org/10.1093/biolre/ioz164.

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Abstract Radiation induces ovarian damage and accelerates reproductive aging. Inbred mouse strains exhibit differential sensitivity to lethality induced by total body irradiation (TBI), with the BALB/cAnNCrl (BALB/c) strain being more sensitive than the 129S2/SvPasCrl (129) strain. However, whether TBI-induced ovarian damage follows a similar pattern of strain sensitivity is unknown. To examine this possibility, female BALB/c and 129 mice were exposed to a single dose of 1 Gy (cesium-137 γ) TBI at 5 weeks of age, and ovarian tissue was harvested for histological and gene expression analyses 2

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Nardiello, Tricia Lynn, Josephine Ruth Giles, and Sharon A. Stranford. "Differential Protease Activity in the Secondary Lymphoid Tissues of Disease Resistant and Susceptible Mouse Strains in the MAIDS Model (45.12)." Journal of Immunology 178, no. 1_Supplement (2007): S59. http://dx.doi.org/10.4049/jimmunol.178.supp.45.12.

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Abstract Murine leukemia virus (MuLV) is used as a mouse model system to study human AIDS. There are two strains of mice used in this model, BALB/c and C57 BL/6. Although both strains of mice will become infected, BALB/c strain recover while the BL/6 strain becomes immunocompromised (MAIDS). Previous DNA microarray work comparing the two strains has shown that certain proteases are up regulated in the BALB/c lymph nodes and spleen shortly after infection. Lymphatic remolding and cell activation are possible consequences of protease activity, and therefore the up regulation of these proteases i

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4

Darville, Toni, Charles W. Andrews, James D. Sikes, Patrick L. Fraley, and Roger G. Rank. "Early Local Cytokine Profiles in Strains of Mice with Different Outcomes from Chlamydial Genital Tract Infection." Infection and Immunity 69, no. 6 (2001): 3556–61. http://dx.doi.org/10.1128/iai.69.6.3556-3561.2001.

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ABSTRACT In this study, we expand on the examination of genetically determined differences in host responses that correlate with clearance of Chlamydia trachomatis from the genital tract. We infected C57BL/6, BALB/c, and C3H/HeN mice with the mouse pneumonitis agent of C. trachomatis (MoPn). C57BL/6 mice had the shortest course of infection (22 days) and the lowest incidence of severe hydrosalpinx. BALB/c mice also had a short course of infection (25 days), but all developed hydrosalpinx. C3H/HeN mice had the longest course of infection (38 days), and all developed severe hydrosalpinx. Determi

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5

Lopez, D. M., R. J. Pauley, and B. B. Lozzio. "Interaction of the heterozygous nude gene with the asplenia trait in mammary tumorigenesis." Journal of Experimental Medicine 161, no. 3 (1985): 629–34. http://dx.doi.org/10.1084/jem.161.3.629.

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The BALB/c mouse strain has been shown to contain endogenous mouse mammary tumor virus (MMTV) proviral sequences. However, no exogenous MMTV particles have been detected in their tissues. Female BALB/c mice from our colonies exhibit a very low incidence of spontaneous mammary tumors (SMT); less than 1% at up to 20 mo of age. Immunodeficient BALB/c mice heterozygous for the nude gene (nu/+, +/+), for the dominant hemimelia gene associated with asplenia (+/+, Dh/+), or for both traits (nu/+, Dh/+) have been examined for SMT incidence and the presence of MMTV proviruses. Based on restriction dige

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6

Goto, H., J. I. Rojas, L. Sporrong, P. de Carreira, C. Sánchez, and A. Örn. "Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains." Revista do Instituto de Medicina Tropical de São Paulo 37, no. 6 (1995): 475–81. http://dx.doi.org/10.1590/s0036-46651995000600001.

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We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studi

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Rival, Claudia, Hui Qiao, Alberta Paul та Kenneth Tung. "Critical mouse strain dependency of IL17A and IFNγ requirements in experimental autoimmune orchitis (EAO) (83.5)". Journal of Immunology 184, № 1_Supplement (2010): 83.5. http://dx.doi.org/10.4049/jimmunol.184.supp.83.5.

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Abstract Many autoimmune diseases depend critically on the proinflammatory cytokines IFNγ and IL17, but their relative contribution is controversial. This may be due to variations in mouse strain, adjuvant and autoimmune model. For example, IL17 is deemed critical for EAE and collagen-induced arthritis in B6, whereas IFNγ is critical in proteoglycan-induced arthritis in BALB/c. EAO develops in B6, BALB/c, and (BALB/cxB6) F1 (F1) mice after immunization with testis Ag in CFA and pertussis. Herein, we compared their cytokine requirements using gene KO mice (IFNγ, IL17A) and cytokine Ab blockade.

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8

Chen, Chun-Rong, H. Aliesky, P. N. Pichurin, Y. Nagayama, S. M. McLachlan, and B. Rapoport. "Susceptibility Rather than Resistance to Hyperthyroidism Is Dominant in a Thyrotropin Receptor Adenovirus-Induced Animal Model of Graves’ Disease as Revealed by BALB/c-C57BL/6 Hybrid Mice." Endocrinology 145, no. 11 (2004): 4927–33. http://dx.doi.org/10.1210/en.2004-0716.

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Abstract We investigated why TSH receptor (TSHR) adenovirus immunization induces hyperthyroidism more commonly in BALB/c than in C57BL/6 mice. Recent modifications of the adenovirus model suggested that using adenovirus expressing the TSHR A subunit (A-subunit-Ad), rather than the full-length TSHR, and injecting fewer viral particles would increase the frequency of hyperthyroidism in C57BL/6 mice. This hypothesis was not fulfilled; 65% of BALB/c but only 5% of C57BL/6 mice developed hyperthyroidism. TSH binding inhibitory antibody titers were similar in each strain. Functional TSHR antibody me

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Gingles, Neill A., Janet E. Alexander, Aras Kadioglu, et al. "Role of Genetic Resistance in Invasive Pneumococcal Infection: Identification and Study of Susceptibility and Resistance in Inbred Mouse Strains." Infection and Immunity 69, no. 1 (2001): 426–34. http://dx.doi.org/10.1128/iai.69.1.426-434.2001.

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ABSTRACT From a panel of nine inbred mice strains intranasally infected withStreptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesio

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Vladimirov, Vladimir, Jana Badalová, Milena Svobodová, et al. "Different Genetic Control of Cutaneous and Visceral Disease after Leishmania major Infection in Mice." Infection and Immunity 71, no. 4 (2003): 2041–46. http://dx.doi.org/10.1128/iai.71.4.2041-2046.2003.

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ABSTRACT The mouse strains BALB/cHeA (BALB/c) and STS/A (STS) are susceptible and resistant to Leishmania major-induced disease, respectively. We analyzed this difference using recombinant congenic (RC) BALB/c-c-STS/Dem (CcS/Dem) strains that carry different random subsets of 12.5% genes of the strain STS in a BALB/c background. Previously, testing the resistant strain CcS-5, we found five novel Lmr (Leishmania major response) loci, each associated with a different combination of pathological and immunological reactions. Here we analyze the response of RC strain CcS-16, which is even more susc

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Iwamoto, Chika, Katsuto Takenaka, Shingo Urata, et al. "BALB/c- Specific L29V Polymorphism In SIRPA Determines The Efficient Engraftment Of Human Hematopoiesis In Xenogeneic Model." Blood 122, no. 21 (2013): 337. http://dx.doi.org/10.1182/blood.v122.21.337.337.

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Abstract It has been shown that in xenotransplantation of human cells into immunodeficient mice, the mouse strain background is critical. For example, the non-obese diabetic (NOD) strain is most efficient, the BALB/c is moderate, and the C57BL/6 is inefficient for human cell engraftment. We have shown that the NOD-specific polymorphism of the signal regulatory protein-alpha (Sirpa) allows NOD SIRPA to bind human CD47, and the resultant “don’t eat me” signaling by this binding prevents host macrophages to engulf human grafts, thereby inhibiting rejection. We then developed the C57BL/6.Rag2nullI

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12

Stokes, Kate, Sujin Lee, Michael Chi, Carla Sturkie, R. Peebles, and Martin Moore. "RSV Strain 2-20 Induces More Severe Disease in BALB/c Mice than RSV Strain 3-12 (39.25)." Journal of Immunology 184, no. 1_Supplement (2010): 39.25. http://dx.doi.org/10.4049/jimmunol.184.supp.39.25.

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Abstract Respiratory syncytial virus (RSV) is the chief cause of bronchiolitis and viral pneumonia in infants. Mucus production contributes to morbidity and mortality in RSV disease. The TH2 cytokine IL-13 is a mediator of mucus production. RSV strain differences can play a role in differential immunologic phenotypes. The pathogenesis of RSV clinical isolate strains was examined in BALB/c mice. RSV strain 2-20 induced significant weight loss, lung IL-13 levels, and bronchiolitis in BALB/c mice. In contrast, RSV 3-12 exhibited a less severe phenotype similar to the RSV A2 laboratory strain. Muc

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13

Massett, Michael P., and Bradford C. Berk. "Strain-dependent differences in responses to exercise training in inbred and hybrid mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 4 (2005): R1006—R1013. http://dx.doi.org/10.1152/ajpregu.00476.2004.

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The aim of this study was to characterize the response to exercise training in several mouse strains and estimate the genetic contribution to phenotypic variation in the responses to exercise training. Male mice from three inbred strains [C57Bl/6J (BL6), FVB/NJ (FVB), and Balb/cJ (Balb/c)] and three hybrid F1 strains [CB6F1/J (CB6 = female Balb/c × male BL6), B6F F1 (female BL6 × male FVB), and FB6 F1 (female FVB × male BL6)] completed an exercise performance test before and after a 4-wk treadmill running program. Distance was used as the primary estimate of endurance exercise performance. FVB

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14

Zhang, Shuling-L., Wendy DuBois, Edward S. Ramsay, et al. "Efficiency Alleles of the Pctr1 Modifier Locus for Plasmacytoma Susceptibility." Molecular and Cellular Biology 21, no. 1 (2001): 310–18. http://dx.doi.org/10.1128/mcb.21.1.310-318.2001.

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ABSTRACT The susceptibility of BALB/c mice to pristane-induced plasmacytomas is a complex genetic trait involving multiple loci, while DBA/2 and C57BL/6 strains are genetically resistant to the plasmacytomagenic effects of pristane. In this model system for human B-cell neoplasia, one of the BALB/c susceptibility and modifier loci, Pctr1, was mapped to a 5.7-centimorgan (cM) chromosomal region that includedCdkn2a, which encodes p16INK4a and p19ARF, and the coding sequences for the BALB/c p16INK4a and p19ARF alleles were found to be polymorphic with respect to their resistant Pctr1counterparts

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15

Sánchez-González, Berenice, Francisco Javier García-Vázquez, José Eduardo Farfán-Morales, and Luis Antonio Jiménez-Zamudio. "Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse." Mediators of Inflammation 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/313140.

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BALB/c strain mice are unique in that they develop murine plasmacytoma (MPC) as a consequence of the inflammation induced by pristane oil injection in the peritoneal cavity. In this work the Treg, Th17, B1, B2, and NHC lymphocyte populations from the peritoneal environment of BALB/c, the susceptible strain, and C57BL/6 mice, which do not develop MPC after oil treatment, were studied. Both oil-treated strains showed decreased levels of Th17 lymphocytes, no significant variation in Treg lymphocytes, and a drastic decrease of all B lymphocyte populations. However, only oil-induced BALB/c showed i

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Barbosa, Cecilia Gomes, Tamires Marielem Carvalho Costa, Chamberttan Souza Desidério, et al. "Trypanosoma cruzi Mexican Strains Differentially Modulate Surface Markers and Cytokine Production in Bone Marrow-Derived Dendritic Cells from C57BL/6 and BALB/c Mice." Mediators of Inflammation 2019 (September 15, 2019): 1–14. http://dx.doi.org/10.1155/2019/7214798.

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Dendritic cells (DCs) are a type of antigen-presenting cells that play an important role in the immune response against Trypanosoma cruzi, the causative agent of Chagas disease. In vitro and in vivo studies have shown that the modulation of these cells by this parasite can directly affect the innate and acquired immune response of the host in order to facilitate its biological cycle and the spreading of the species. Many studies show the mechanisms by which T. cruzi modulates DCs, but the interaction of these cells with the Mexican strains of T. cruzi such as Ninoa and INC5 has not yet been pr

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17

Leo, O., M. Slaoui, J. Marvel, et al. "Idiotypic analysis of polyclonal and monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain." Journal of Immunology 134, no. 3 (1985): 1734–39. http://dx.doi.org/10.4049/jimmunol.134.3.1734.

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Abstract The idiotypic cascade allows the induction of silent idiotypes, and as such, the immune system can be reprogrammed towards predetermined goals. To understand the genetic origin of silent idiotypes, we have used a system in which detailed structural and genetic information is available. The major cross-reactive idiotype (CRIA) of A/J mice (positive strain) immunized with arsonate coupled to a carrier can be regularly induced in BALB/c mice (negative strain) by anti-idiotypic treatment with or without subsequent antigen immunization. By using a panel of monoclonal anti-idiotypic antibod

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Irion, Camila I., Monique Williams, Jose Condor Capcha, et al. "Col4a3-/- Mice on Balb/C Background Have Less Severe Cardiorespiratory Phenotype and SGLT2 Over-Expression Compared to 129x1/SvJ and C57Bl/6 Backgrounds." International Journal of Molecular Sciences 23, no. 12 (2022): 6674. http://dx.doi.org/10.3390/ijms23126674.

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Alport syndrome (AS) is a hereditary renal disorder with no etiological therapy. In the preclinical Col4a3-/- model of AS, disease progression and severity vary depending on mouse strain. The sodium-glucose cotransporter 2 (SGLT2) is emerging as an attractive therapeutic target in cardiac/renal pathologies, but its application to AS remains untested. This study investigates cardiorespiratory function and SGLT2 renal expression in Col4a3-/- mice from three different genetic backgrounds, 129x1/SvJ, C57Bl/6 and Balb/C. male Col4a3-/- 129x1/SvJ mice displayed alterations consistent with heart fail

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Nolan, Kylie J., David J. McGee, Hazel M. Mitchell, et al. "In Vivo Behavior of a Helicobacter pylori SS1 nixA Mutant with Reduced Urease Activity." Infection and Immunity 70, no. 2 (2002): 685–91. http://dx.doi.org/10.1128/iai.70.2.685-691.2002.

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ABSTRACT Helicobacter pylori mutants devoid of urease activity fail to colonize the gastric mucosa of mice; however, the effect of decreased levels of urease on colonization has not been examined. The nixA gene, required for full urease activity, encodes a cytoplasmic membrane nickel transporter that imports nickel ions and leads to incorporation of nickel ions into apourease. A nixA mutant of the Sydney strain of H. pylori (SS1) was constructed by disruption of the nixA gene with a kanamycin resistance cassette. This mutant retained only half the urease activity of the wild-type (wild-type) S

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Kołodziej-Sobocińska, M., and B. Machnicka-Rowińska. "In vivo inhibition of inducible nitric oxide synthase by aminoguanidine influences free radicals production and macrophage activity in Trichinella spiralis infected low responders (C57BL/6) and high responders (BALB/c) mice." Helminthologia 49, no. 4 (2012): 189–200. http://dx.doi.org/10.2478/s11687-012-0038-6.

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AbstractThe influence of aminoguanidine (AG) — inhibitor of inducible nitric oxide synthase (iNOS), on macrophage activity and free radicals level was examined during Trichinella spiralis infection in two strains of mice: C57BL/6 and BALB/c. AG was administered either between 1–5 days post infection (dpi) for intestinal phase examinations or between 16–29 dpi for muscle phase examinations. The number of peritoneal macrophages and level of nitric oxide NO) and hydrogen peroxide (H2O2) in biological fluids were determined in both strains after infection or infection together with AG treatment as

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Stokes, Kate, Michael Chi, Kaori Sakamoto, et al. "BALB/c mouse model of RSV clinical isolate A2001/2-20 pathogenesis (49.13)." Journal of Immunology 186, no. 1_Supplement (2011): 49.13. http://dx.doi.org/10.4049/jimmunol.186.supp.49.13.

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Abstract Airway mucus is a hallmark of respiratory syncytial virus (RSV) lower respiratory tract illness. Laboratory RSV strains (A2, Long, and Line 19) differentially induce airway mucus production in mice. We tested whether RSV strains differ in pathogenesis by screening low passage RSV clinical isolates for mucogenicity and virulence in BALB/c mice. RSV clinical isolates induced variable disease severity. Infection of BALB/c mice with clinical isolate RSV A2001/2-20 (2-20) resulted in greater disease severity and higher lung IL-13 levels than infection with RSV laboratory strains and other

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Leonard, Sean, B. Anne Croy, and Coral L. Murrant. "Arteriolar reactivity in lymphocyte-deficient mice." American Journal of Physiology-Heart and Circulatory Physiology 301, no. 4 (2011): H1276—H1285. http://dx.doi.org/10.1152/ajpheart.00346.2011.

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Mounting evidence suggests that lymphocytes have the capacity to contribute to the regulation of systemic circulatory control. We postulated that T and natural killer (NK) cells could modify basal microvascular activity under physiologically normal conditions. In situ intravital microscopy of mouse cremaster vasculature was used to evaluate arteriolar reactivities to the vasoconstrictors angiotensin II (ANG II) and phenylephrine (Phe) and the vasodilators acetylcholine (ACh) and adenosine (Ado) in normal [+/+; wild type (WT)] and genetically immunodeficient (T−B−NK+ or T−B−\NK−) C57BL/6 and BA

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Barone, F. C., D. J. Knudsen, A. H. Nelson, G. Z. Feuerstein, and R. N. Willette. "Mouse Strain Differences in Susceptibility to Cerebral Ischemia are Related to Cerebral Vascular Anatomy." Journal of Cerebral Blood Flow & Metabolism 13, no. 4 (1993): 683–92. http://dx.doi.org/10.1038/jcbfm.1993.87.

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The consequences of cerebral ischemia were studied in three different strains (BDF, CFW, and BALB/C) of mice. The different strains exhibited significant differences in susceptibility to 24-h focal ischemia. Following middle cerebral artery occlusion (MCAO), infarct volumes (mm3) were 5 ± 3 in BDF, 15 ± 5 in CFW, and 23 ± 3 in BALB/C mice (p < 0.05). MCAO plus ipsilateral common carotid artery occlusion (CCAO) resulted in infarct volumes of 15 ± 9 in BDF, 38 ± 10 in CFW, and 72 ± 12 in BALB/C mice (p < 0.05). In addition, MCAO plus CCAO produced death by 24 h in 42% of CFW and 67% of BAL

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CHEN, S. J., Y. X. ZHANG, S. G. HUANG, and F. L. LU. "Galectins expressed differently in genetically susceptible C57BL/6 and resistant BALB/c mice during acute ocularToxoplasma gondiiinfection." Parasitology 144, no. 8 (2017): 1064–72. http://dx.doi.org/10.1017/s0031182017000270.

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SUMMARYOcular toxoplasmosis (OT) caused byToxoplasma gondiiis a major cause of infectious uveitis, however little is known about its immunopathological mechanism. Susceptible C57BL/6 (B6) and resistant BALB/c mice were intravitreally infected with 500 tachyzoites of the RH strain ofT. gondii. B6 mice showed more severe ocular pathology and higher parasite loads in the eyes. The levels of galectin (Gal)-9 and its receptors (Tim-3 and CD137), interferon (IFN)-γ, IL-6 and IL-10 were significantly higher in the eyes of B6 mice than those of BALB/c mice; however, the levels of IFN-αand -βwere signi

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Pinelli, E., J. Dormans, M. Fonville, and J. van der Giessen. "A comparative study of toxocariasis and allergic asthma in murine models." Journal of Helminthology 75, no. 2 (2001): 137–40. http://dx.doi.org/10.1079/joh200171.

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AbstractHistopathology of the lung and total IgE in serum were compared in toxocariasis and allergic asthma murine models using BALB/c and C57BL/6 mice. Infection with Toxocara canis resulted in both strains of mice in marked histological changes and increased levels of total serum IgE. The ovalbumin (OVA) sensitization/challenge treatment for the induction of allergic asthma resulted in similar histological changes in BALB/c and, to a less extent, in C57BL/6 mice. Serum IgE levels of OVA-treated C57BL/6 mice were low. Histological changes observed included perivascular infiltration with eosin

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Ozaki, Masakazu, Keisuke Ozaki, Tomoyuki Watanabe, Satoshi Uwagawa, Yasuyoshi Okuno, and Tomoyuki Shirai. "Susceptibilities of p53 Knockout and rasH2 Transgenic Mice to Urethane-Induced Lung Carcinogenesis are Inherited from their Original Strains." Toxicologic Pathology 33, no. 2 (2005): 267–71. http://dx.doi.org/10.1080/01926230590908231.

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In the present study, susceptibility of CB6F1 mice carrying the human prototype c-Ha- ras gene (rasH2 mice) and p53 gene knockout mice ( p53 (+/−) mice) to urethane-induced lung carcinogenesis was compared under the same experimental conditions. Both strains were administered 500 ppm urethane in their drinking water for 3 weeks. At week 26, lung adenocarcinomas and adenomas were observed in 53% and 100% of rasH2 mice, respectively, and lung adenomas were observed in 67% of rasH2 littermate (non-Tg) mice. However, lung tumors were not observed in either p53 (+/−) or p53 (+/+) mice. Peliosis hep

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Taherzadeh, Zhila, Ed VanBavel, Judith de Vos, et al. "Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex." American Journal of Physiology-Heart and Circulatory Physiology 298, no. 4 (2010): H1273—H1282. http://dx.doi.org/10.1152/ajpheart.00508.2009.

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Hypertension is associated with chronic vascular inflammation. We tested the hypothesis that the sensitivity to develop hypertension and vascular remodeling depends on the immunological background. Blood pressure, vascular remodeling, endothelial function, vascular architecture (number of collateral arteries), and expression of inflammatory cytokines were determined in mice that received NG-nitro-l-arginine methyl ester (l-NAME) to inhibit nitric oxide synthesis. We studied C57BL/6, BALB/c, and BALB.B6-Cmv1r mice, a congenic strain where the natural killer (NK) gene complex of C57BL/6 mice is

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Nicholson, S. M., M. C. Dal Canto, S. D. Miller, and R. W. Melvold. "Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice." Journal of Immunology 156, no. 3 (1996): 1276–83. http://dx.doi.org/10.4049/jimmunol.156.3.1276.

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Abstract On intracerebral infection with the BeAn strain of Theiler's murine encephalomyelitis virus (TMEV), certain mouse strains develop a chronic demyelinating disease similar both clinically and pathologically to human multiple sclerosis. Other strains remain resistant. We previously established that differential susceptibility to this demyelinating disease exists among BALB/c substrains, with BALB/cAnNCr mice being susceptible while BALB/cByJ mice are resistant. BALB/cByJ mice are rendered susceptible to TMEV-induced demyelination on exposure to low dose gamma-irradiation before TMEV infe

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MacLeod, Heather, Debbie Goodwin, Christy Damphousse, and Cheryl Nickerson-Nutter. "Cyclosporine A and CTLA-4Ig differentially inhibit the effector phase of the DTH response in two separate mouse strains (48.20)." Journal of Immunology 182, no. 1_Supplement (2009): 48.20. http://dx.doi.org/10.4049/jimmunol.182.supp.48.20.

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Abstract Delayed type hypersensitivity (DTH) is classically defined as inflammation involving antigen presentation, cytokine production and T cell activation. Both the Balb/c strain and the autoimmune-prone B6D2F1 strain develop a DTH response. However, DTH in the Balb/c strain is inhibited by the immunosuppressive agent cyclosporine A (CsA), which blocks NFAT activity, whereas DTH in the B6D2F1 strain is not. Balb/c mice generate a traditional Th1 cytokine response that is inhibited by CsA, while B6D2F1 mice produce lower levels of Th1 cytokines and not all are reduced by CsA. Since T cell ac

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Takeda, K., A. Haczku, J. J. Lee, C. G. Irvin, and E. W. Gelfand. "Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung." American Journal of Physiology-Lung Cellular and Molecular Physiology 281, no. 2 (2001): L394—L402. http://dx.doi.org/10.1152/ajplung.2001.281.2.l394.

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Different strains of mice exhibit different degrees of airway hyperresponsiveness after sensitization to and airway challenge with ovalbumin. Antibody responses in BALB/c mice far exceeded those in C57BL/6 mice; in contrast, although responsiveness to methacholine was much higher in the BALB/c mice, the number of eosinophils in the bronchoalveolar lavage fluid was higher in C57BL/6 animals. Sensitized and challenged BALB/c mice developed increases in lung resistance and decreases in dynamic compliance after methacholine or 5-hydroxytryptamine inhalation. C57BL/6 mice only exhibited significant

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Kang, Hye-Min, Inkyung Sohn, Seunggyu Kim, et al. "Optical Measurement of Mouse Strain Differences in Cerebral Blood Flow Using Indocyanine Green." Journal of Cerebral Blood Flow & Metabolism 35, no. 6 (2015): 912–16. http://dx.doi.org/10.1038/jcbfm.2015.50.

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C57BL/6 mice have more cerebral arterial branches and collaterals than BALB/c mice. We measured and compared blood flow dynamics of the middle cerebral artery (MCA) in these two strains, using noninvasive optical imaging with indocyanine green (ICG). Relative maximum fluorescence intensity ( Imax) and the time needed for ICG to reach Imax in the MCA of C57BL/c were lower than that in BALB/c mice. Moreover, the mean transit time was significantly lower in C57BL/6 than in BALB/c mice. These data suggest that the higher number of arterial branches and collaterals in C57BL/6 mice yields a lower bl

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Alcorn, John F., Karina Ckless, Amy L. Brown та ін. "Strain-dependent activation of NF-κB in the airway epithelium and its role in allergic airway inflammation". American Journal of Physiology-Lung Cellular and Molecular Physiology 298, № 1 (2010): L57—L66. http://dx.doi.org/10.1152/ajplung.00037.2009.

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NF-κB activation in the airway epithelium has been established as a critical pathway in ovalbumin (Ova)-induced airway inflammation in BALB/c mice (Poynter ME, Cloots R, van Woerkom T, Butnor KJ, Vacek P, Taatjes DJ, Irvin CG, Janssen-Heininger YM. J Immunol 173: 7003–7009, 2004). BALB/c mice are susceptible to the development of allergic airway disease, whereas other strains of mice, such as C57BL/6, are considered more resistant. The goal of the present study was to determine the proximal signals required for NF-κB activation in the airway epithelium in allergic airway disease and to unravel

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Packiam, Mathanraj, Sandra J. Veit, Deborah J. Anderson, Robin R. Ingalls, and Ann E. Jerse. "Mouse Strain-Dependent Differences in Susceptibility to Neisseria gonorrhoeae Infection and Induction of Innate Immune Responses." Infection and Immunity 78, no. 1 (2009): 433–40. http://dx.doi.org/10.1128/iai.00711-09.

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ABSTRACT Acute gonorrhea in women is characterized by a mucopurulent exudate that contains polymorphonuclear leukocytes (PMNs) with intracellular gonococci. Asymptomatic infections are also common. Information on the innate response to Neisseria gonorrhoeae in women is limited to studies with cultured cells, isolated immune cells, and analyses of cervicovaginal fluids. 17β-Estradiol-treated BALB/c mice can be experimentally infected with N. gonorrhoeae, and a vaginal PMN influx occurs in 50 to 80% of mice. Here, we compared the colonization loads and proinflammatory responses of BALB/c, C57BL/

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Pugh, George W., Emilie S. Zehr, Vincent P. Meador, Marshall Phillips, Timothy J. McDonald, and Billy L. Deyoe. "Immunologic, histopathologic, and bacteriologic responses of five strains of mice to Brucella abortus strain 2308." American Journal of Veterinary Research 50, no. 3 (1989): 323–28. https://doi.org/10.2460/ajvr.1989.50.03.323.

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SUMMARY A study was conducted to establish baseline data on Brucella abortus infection induced in 5 strains of mice (CBA/NJ, BALB/c, CD-1, C3H/HeN, and C3H/HeJ). The strains were compared on the basis of immunologic, histopathologic, and bacteriologic responses. There were 4 treatment groups for each strain of mice: (1) vaccinated with homologous lipopolysaccharide and challenge exposed to B abortus strain 2308; (2) not vaccinated but challenge exposed; (3) vaccinated but not challenge exposed; and (4) not vaccinated and not challenge exposed. Results indicated that mice can be used for compar

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Neill, A. L., and N. H. Hunt. "Pathology of fatal and resolving Plasmodium berghei cerebral malaria in mice." Parasitology 105, no. 2 (1992): 165–75. http://dx.doi.org/10.1017/s0031182000074072.

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SUMMARYCBA/T6 and Balb/c mice inoculated with Plasmodium berghei ANKA strain (PbA) died from cerebral malaria 6–8 days post-inoculation. DBA/2J mice similarly inoculated developed a non-fatal cerebral malaria, with mild temporary cerebral symptoms, and died between days 15 and 22 from other malaria-related complications. When inoculated with P. berghei K173 (Pb) these mouse strains did not develop a cerebral malaria but died between days 15 and 22 from other malaria-related complications. These mouse strain/parasite strain combinations allow for detailed examination of factors critical in the

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Lichtenstein, Jamie H. Rosenblum, Thomas C. Donaghey, Ramon M. Molina, and Joseph D. Brain. "Mouse strain affects Stachybotrys chartarum induced alveolar macrophage cytotoxicity (51.9)." Journal of Immunology 178, no. 1_Supplement (2007): S98. http://dx.doi.org/10.4049/jimmunol.178.supp.51.9.

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Abstract The fungus Stachybotrys chartarum (S. chartarum) releases mycotoxins that can cause lung injury, inflammation, hemorrhage and cytotoxicity. We have shown that when BALB/c mice receive instilled spores, they have greater lung inflammation, hemorrhage, and cytokine production and less efficient spore clearance than C57BL/6J mice. To investigate these mouse strain differences, we exposed alveolar macrophages (AMs) lavaged from these two strains of mice to spores in vitro. Then the cells were stained with calcein AM (live) and EthD1 (dead), and images were collected on a BD Pathway Bioima

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Toka, Felix, Patryk Dolega, Matylda Mielcarska, and Magdalena Bossowska. "Comparison of messenger RNA expression profile of antiviral innate immune response genes in peritoneal macrophages from BALB/c and C57BL/6 mice infected with ectromelia virus (INM3P.413)." Journal of Immunology 194, no. 1_Supplement (2015): 127.18. http://dx.doi.org/10.4049/jimmunol.194.supp.127.18.

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Abstract Although a few mechanisms have explained how, for instance ectromelia virus (ECTV), is successful in causing fatal disease in certain strains of mice and how other strains are not susceptible, a global transcription overview of innate immunity genes is not entirely known. Poxviruses have evolved several mechanisms to avoid immune response of an infected host. Here we have studied the innate gene transcriptional response of BALB/c and C57BL/6 mice peritoneal macrophages to infection with ECTV Moscow strain (ECTV-Mos). Indeed, assessment of four categories of antiviral innate immune res

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Morris, Mariya G., Rodolfo J. Ricart Arbona, Kathleen Daniels, et al. "Mite Burden and Immunophenotypic Response to Demodex musculi in Swiss Webster, BALB/c, C57BL/6, and NSG Mice." Comparative Medicine 70, no. 4 (2020): 336–48. http://dx.doi.org/10.30802/aalas-cm-19-000097.

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Detection methods for Demodex musculi were historically unreliable, and testing was rarely performed because its prevalence in laboratory mice was underestimated. Although infestations are unapparent in most mouse strains, D. musculi burdens are higher and clinical signs detected in various immunodeficient strains. The parasite's influence on the immune system of immunocompetent mice is unknown. We characterized mite burden (immunocompetent and immunodeficient strains) and immunologic changes (immunocompetent strains only) in naïve Swiss Webster (SW; outbred), C57BL/6NCrl (B6; Th1 responder),

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Markusic, David M. "Immune Response to FIX Is Dependent on Mouse Background Strain and Modulated By TLR4." Blood 124, no. 21 (2014): 1479. http://dx.doi.org/10.1182/blood.v124.21.1479.1479.

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Abstract Introduction Many investigators rely on mouse models to study immune responses against factor IX protein (FIX) products. While it is recognized that there are distinct differences in immune responses towards FIX in different mouse strains, there is an absence of studies conducted on mice with a F9 gene deletion. Our laboratory has developed protocols to prevent or reverse ongoing anti-hFIX IgG inhibitors in hemophilia B mice with a F9 gene deletion (F9-/Y) on both a BALB/c and C3H/HeJ background. Interestingly C3H/HeJ F9-/Y mice develop high titer anti-FIX IgG1 inhibitors and anaphyla

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Chen, Mei, Fumie Aosai, Hye-Seong Mun, Kazumi Norose, Hidekazu Hata, and Akihiko Yano. "Anti-HSP70 Autoantibody Formation by B-1 Cells inToxoplasma gondii-Infected Mice." Infection and Immunity 68, no. 9 (2000): 4893–99. http://dx.doi.org/10.1128/iai.68.9.4893-4899.2000.

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ABSTRACT Formation of anti-Toxoplasma gondii HSP70 (TgHSP70) antibody cross-reactive to mouse HSP70 (mHSP70) was observed in the sera of BALB/c (a resistant strain) and C57BL/6 (B6; a susceptible strain) mice after peroral infection with T. gondii cysts of the Fukaya strain. The levels of anti-mHSP70 immunoglobulin G (IgG) autoantibody production in B6 mice were higher than those in BALB/c mice. The isotype and subclass of IgG of anti-TgHSP70 monoclonal antibodies cross-reactive to mHSP70 were μ and γ3. Anti-mHSP70 autoantibody in T. gondii-infected BALB/c and B6 mice was shown to be produced

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Vidal, José, and Adela Fusté. "Antibody Response and Some Behaviors as Differential Traits between Two Inbred Strains of Mice (C57BL/6 and BALB/c)." Psychological Reports 72, no. 1 (1993): 111–20. http://dx.doi.org/10.2466/pr0.1993.72.1.111.

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The goals of this research were to find out if the antibody response and some behaviors are differential traits for murine strains C57BL/6 and BALB/c and to study the influence of strain and isolation on both behavior and the antibody response. 21 C57BL/6 male mice and 28 BALB/c male mice were used; of those, 11 C57BL/6 and 16 BALB/c were kept isolated, and the remaining mice were housed 2 per cage. The tests were Open-fields 1, 2, and 3 (of varying light and sound stimulation), holeboard, light-darkness test, immunization with rat erythrocytes; in addition, the mice were weighed. The traits t

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Fried, B., and R. C. Peoples. "Longevity ofEchinostoma caproniin Balb/c mice." Journal of Helminthology 82, no. 1 (2008): 95–96. http://dx.doi.org/10.1017/s0022149x0785824x.

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AbstractThis study used Balb/c mice to examine the longevity ofEchinostoma caproni. Five mice each exposed to 75 encysted metacercariae (cysts) were necropsied at 23 weeks postinfection (PI) (160 days PI). Two of the 5 were infected with a total of 33 worms; 23 in one mouse and 10 in the other. Body and organ area measurements showed that these worms were robust and normal in appearance. No signs of atrophy of any of the genital structures were observed. The mean ± SE of eggs/uterus per worm (n = 10) was 243 ± 6. This strain of mouse will be suitable to study the effect of long-term survival o

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Bandouchova, H., J. Sedlackova, M. Hubalek, et al. "Susceptibility of selected murine and microtine species to infection by a wild strain of Francisella tularensis subsp. holoarctica." Veterinární Medicína 54, No. 2 (2009): 64–74. http://dx.doi.org/10.17221/1913-vetmed.

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The purpose of this study was to compare susceptibility of BALB/c mice, common voles (<i>Microtus arvalis</i>) and yellow-necked mice (<i>Apodemus flavicollis</i>) to infection by a virulent <i>Francisella tularensis</i> subsp. <i>holarctica</i> strain. Median survival in these three species following experimental infection with 320 colony forming units of <i>F. tularensis</i> (both intraperitoneally and subcutaneously) amounted to 4.5, 7 and 4 days, respectively. Survival curves of BALB/c and yellow-necked mice were very similar and

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Santos, Amanda Ribeiro dos, Thais Fernanda Fraga-Silva, Débora de Fátima Almeida-Donanzam, et al. "Is the production of reactive oxygen and nitrogen species by macrophages associated with better infectious control in female mice with experimentally disseminated and pulmonary mucormycosis?" PLOS ONE 17, no. 12 (2022): e0270071. http://dx.doi.org/10.1371/journal.pone.0270071.

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Different levels of resistance against Rhizopus oryzae infection have been observed between inbred (BALB/c) and outbred (Swiss) mice and are associated with the genetic background of each mouse strain. Considering that macrophages play an important role in host resistance to Rhizopus species, we used different infectious outcomes observed in experimental mucormycosis to identify the most efficient macrophage response pattern against R. oryzae in vitro and in vivo. For this, we compared BALB/c and Swiss macrophage activity before and after intravenous or intratracheal R. oryzae infections. The

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Medina-Buelvas, Dunia M., Miriam Rodríguez-Sosa, and Libia Vega. "Characterisation of Macrophage Polarisation in Mice Infected with Ninoa Strain of Trypanosoma cruzi." Pathogens 10, no. 11 (2021): 1444. http://dx.doi.org/10.3390/pathogens10111444.

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Macrophages (MΦ) play a key role in the development of the protective immune response against Trypanosoma cruzi infection. To determine the role of MΦ subtypes M1 and M2 in the development of immunity against the Mexican strain of T. cruzi (Ninoa strain), we have analysed in a time course the infection and characterised the M1 and M2 subtypes in two mouse models, BALB/c and C57BL/6. After infection, BALB/c mice developed an increased blood parasite load and the parasites were cleared from the blood one week later than in C57BL/6 mice. However, similar cellular infiltrate and cardiac alteration

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Clawson, Michael L., Natalia Paciorkowski, T. V. Rajan, et al. "Cellular Immunity, but Not Gamma Interferon, Is Essential for Resolution of Babesia microti Infection in BALB/c Mice." Infection and Immunity 70, no. 9 (2002): 5304–6. http://dx.doi.org/10.1128/iai.70.9.5304-5306.2002.

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ABSTRACT A new strain of Babesia microti (KR-1) was isolated from a Connecticut resident with babesiosis by hamster inoculation and adapted to C3H/HeJ and BALB/c mice. To examine the relative importance of humoral and cellular immunity for the control of B. microti infection, we compared the course of disease in wild-type BALB/c mice with that in BALB/c SCID mice, JHD-null (B-cell-deficient) mice, and T-cell receptor αβ (TCRβ−/−) or gamma interferon (IFN-γ) (IFN-γ−/−) knockout mice following inoculation with the KR-1-strain. SCID mice and TCRαβ knockouts sustained a severe but nonlethal parasi

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Obermueller, B., C. Castellani, H. Till, B. Reininger-Gutmann, and G. Singer. "An examination of nest-building behaviour using five different nesting materials in C57BL/6J and BALB/c mice." Animal Welfare 30, no. 4 (2021): 467–77. http://dx.doi.org/10.7120/09627286.30.4.010.

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The aim of our study was to assess the nest-building behaviour of two mouse (Mus musculus) strains using different nesting materials and examine possible sex- and housing-specific effects. Adult mice of two strains (C57BL/6J; n = 64 and BALB/cAnNCrl; n = 99) were randomly allocated to the following housing groups: single-housed male, single-housed female, pair-housed male and pair-housed female. One of the following nest-building materials was placed in each home-cage in a random order: nestlets (Plexx BV, The Netherlands), cocoons (Carfil, Belgium), wooden wool, crinklets and compact (all thr

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Chan, Donovan, Duncan W. Cushnie, Oana R. Neaga, Andrea K. Lawrance, Rima Rozen, and Jacquetta M. Trasler. "Strain-Specific Defects in Testicular Development and Sperm Epigenetic Patterns in 5,10-Methylenetetrahydrofolate Reductase-Deficient Mice." Endocrinology 151, no. 7 (2010): 3363–73. http://dx.doi.org/10.1210/en.2009-1340.

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Methylenetetrahydrofolate reductase (MTHFR) is a crucial folate pathway enzyme that contributes to the maintenance of cellular pools of S-adenosylmethionine, the universal methyl donor for several reactions including DNA methylation. Whereas Mthfr−/− BALB/c mice show growth retardation, developmental delay, and spermatogenic defects and infertility, C57BL/6 mice appear to have a less severe phenotype. In the present study, we investigated the effects of MTHFR deficiency on early germ cell development in both strains and assessed whether MTHFR deficiency results in DNA methylation abnormalities

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Salwa, Fathima, Murali Badanthadka, and Lidwin D’Souza. "Differential Psoriatic Effect of Imiquimod on Balb/c and Swiss Mice." Journal of Health and Allied Sciences NU 11, no. 03 (2021): 170–77. http://dx.doi.org/10.1055/s-0041-1726681.

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Abstract Introduction The influence of animal strain on psoriasis model development by imiquimod (IMQ) has been studied in Balb/c and Swiss mice. Materials and Methods Female mice of either strain were challenged with 5% IMQ (62.5 mg on back skin, 10 mg on right ear). They were observed for the severity of the disease using Psoriasis area severity index (PASI), splenomegaly, and histopathological alterations. To validate the model, well-established antipsoriatic drug clobetasol (0.05%, 120 mg on the back skin, 10 mg on the right ear) was used. Additionally, to study the strain-dependent respon

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Stein, Andreas, Céline Louveau, Hubert Lepidi, et al. "Q Fever Pneumonia: Virulence of Coxiella burnetii Pathovars in a Murine Model of Aerosol Infection." Infection and Immunity 73, no. 4 (2005): 2469–77. http://dx.doi.org/10.1128/iai.73.4.2469-2477.2005.

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ABSTRACT Q fever is a worldwide zoonosis caused by Coxiella burnetii, a strictly intracellular bacterium that is a potential bioweapon. Humans usually acquires Q fever after inhalation of dust infected by subclinical animals. We used an aerosol exposure apparatus to challenge immunocompetent (BALB/c) and severe combined immunodeficient (SCID) mice with two different strains (strain Nine Mile and strain Q 212) of C. burnetii at two different inocula. Pathological lesions and dissemination of the bacteria were related to the size of the inoculum. SCID mice showed major pulmonary lesions, whereas

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