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Journal articles on the topic 'Barhl1'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Hou, Kun, Hui Jiang, Md Rezaul Karim, et al. "A Critical E-box in Barhl1 3′ Enhancer Is Essential for Auditory Hair Cell Differentiation." Cells 8, no. 5 (2019): 458. http://dx.doi.org/10.3390/cells8050458.

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Barhl1, a mouse homologous gene of Drosophila BarH class homeobox genes, is highly expressed within the inner ear and crucial for the long-term maintenance of auditory hair cells that mediate hearing and balance, yet little is known about the molecular events underlying Barhl1 regulation and function in hair cells. In this study, through data mining and in vitro report assay, we firstly identified Barhl1 as a direct target gene of Atoh1 and one E-box (E3) in Barhl1 3’ enhancer is crucial for Atoh1-mediated Barhl1 activation. Then we generated a mouse embryonic stem cell (mESC) line carrying di

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2

Chellappa, Ramesh, Shengguo Li, Sarah Pauley, Israt Jahan, Kangxin Jin, and Mengqing Xiang. "Barhl1 Regulatory Sequences Required for Cell-Specific Gene Expression and Autoregulation in the Inner Ear and Central Nervous System." Molecular and Cellular Biology 28, no. 6 (2008): 1905–14. http://dx.doi.org/10.1128/mcb.01454-07.

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ABSTRACT The development of the nervous system requires the concerted actions of multiple transcription factors, yet the molecular events leading to their expression remain poorly understood. Barhl1, a mammalian homeodomain transcription factor of the BarH class, is expressed by developing inner ear hair cells, cerebellar granule cells, precerebellar neurons, and collicular neurons. Targeted gene inactivation has demonstrated a crucial role for Barhl1 in the survival and/or migration of these sensory cells and neurons. Here we report the regulatory sequences of Barhl1 necessary for directing i

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3

Li, Shengguo, Sandy M. Price, Hugh Cahill, David K. Ryugo, Michael M. Shen, and Mengqing Xiang. "Hearing loss caused by progressive degeneration of cochlear hair cells in mice deficient for the Barhl1 homeobox gene." Development 129, no. 14 (2002): 3523–32. http://dx.doi.org/10.1242/dev.129.14.3523.

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The cochlea of the mammalian inner ear contains three rows of outer hair cells and a single row of inner hair cells. These hair cell receptors reside in the organ of Corti and function to transduce mechanical stimuli into electrical signals that mediate hearing. To date, the molecular mechanisms underlying the maintenance of these delicate sensory hair cells are unknown. We report that targeted disruption of Barhl1, a mouse homolog of the Drosophila BarH homeobox genes, results in severe to profound hearing loss, providing a unique model for the study of age-related human deafness disorders. B

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4

Lopes, Carmela, Anne-Lise Delezoide, Jean-Maurice Delabar, and Mohammed Rachidi. "BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system." Biochemical and Biophysical Research Communications 339, no. 1 (2006): 296–304. http://dx.doi.org/10.1016/j.bbrc.2005.11.021.

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5

Dong, Hongyan, Carole L. Yauk, and Michael G. Wade. "Barhl1 is directly regulated by thyroid hormone in the developing cerebellum of mice." Biochemical and Biophysical Research Communications 415, no. 1 (2011): 157–62. http://dx.doi.org/10.1016/j.bbrc.2011.10.041.

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6

Pöschl, J., A. Lorenz, W. Hartmann, et al. "Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans." Oncogene 30, no. 47 (2011): 4721–30. http://dx.doi.org/10.1038/onc.2011.173.

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7

Sud, Richa, Chris M. Jones, Sandro Banfi, and Sally J. Dawson. "Transcriptional regulation by Barhl1 and Brn-3c in organ of corti derived cell lines." Molecular Brain Research 141, no. 2 (2005): 174–80. http://dx.doi.org/10.1016/j.molbrainres.2005.09.007.

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8

Barh, Debmalya, María García-Solano, Sandeep Tiwari, et al. "BARHL1 Is Downregulated in Alzheimer’s Disease and May Regulate Cognitive Functions through ESR1 and Multiple Pathways." Genes 8, no. 10 (2017): 245. http://dx.doi.org/10.3390/genes8100245.

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9

Li, S. "Barhl1 Regulates Migration and Survival of Cerebellar Granule Cells by Controlling Expression of the Neurotrophin-3 Gene." Journal of Neuroscience 24, no. 12 (2004): 3104–14. http://dx.doi.org/10.1523/jneurosci.4444-03.2004.

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10

Li, Shengguo, and Mengqing Xiang. "Barhl1 is required for maintenance of a large population of neurons in the zonal layer of the superior colliculus." Developmental Dynamics 235, no. 8 (2006): 2260–65. http://dx.doi.org/10.1002/dvdy.20858.

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11

Bulfone, A. "Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS." Human Molecular Genetics 9, no. 9 (2000): 1443–52. http://dx.doi.org/10.1093/hmg/9.9.1443.

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12

Rachidi, Mohammed, and Carmela Lopes. "Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning." International Journal of Developmental Neuroscience 24, no. 1 (2005): 35–44. http://dx.doi.org/10.1016/j.ijdevneu.2005.11.015.

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13

Tu, Shu, and Jian Zuo. "Systematic single cell RNA sequencing analysis reveals unique transcriptional regulatory networks of Atoh1-mediated hair cell conversion in adult mouse cochleae." PLOS ONE 18, no. 12 (2023): e0284685. http://dx.doi.org/10.1371/journal.pone.0284685.

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Regeneration of mammalian cochlear hair cells (HCs) by modulating molecular pathways or transcription factors is a promising approach to hearing restoration; however, immaturity of the regenerated HCs in vivo remains a major challenge. Here, we analyzed a single cell RNA sequencing (scRNA-seq) dataset during Atoh1-induced supporting cell (SC) to hair cell (HC) conversion in adult mouse cochleae (Yamashita et al. (2018)) using multiple high-throughput sequencing analytical tools (WGCNA, SCENIC, ARACNE, and VIPER). Instead of focusing on differentially expressed genes, we established independent

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14

Zhong, Chao, Zhenhuang Chen, Xiaocui Luo, et al. "Corrigendum to “Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells” [Int. J. Biochem. Cell Biol. 96 (2018) 79–89]." International Journal of Biochemistry & Cell Biology 97 (April 2018): 128–29. http://dx.doi.org/10.1016/j.biocel.2018.02.009.

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15

Lum, G., and X. J. Min. "FunSecKB: the Fungal Secretome KnowledgeBase." Database 2011 (February 6, 2011): bar001. http://dx.doi.org/10.1093/database/bar001.

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16

Blankenberg, D., N. Coraor, G. Von Kuster, J. Taylor, and A. Nekrutenko. "Integrating diverse databases into an unified analysis framework: a Galaxy approach." Database 2011 (April 29, 2011): bar011. http://dx.doi.org/10.1093/database/bar011.

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17

Raju, R., L. Balakrishnan, V. Nanjappa, et al. "A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway." Database 2011 (July 8, 2011): bar021. http://dx.doi.org/10.1093/database/bar021.

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18

Haw, R. A., D. Croft, C. K. Yung, et al. "The Reactome BioMart." Database 2011 (October 19, 2011): bar031. http://dx.doi.org/10.1093/database/bar031.

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19

Guberman, J. M., J. Ai, O. Arnaiz, et al. "BioMart Central Portal: an open database network for the biological community." Database 2011 (September 18, 2011): bar041. http://dx.doi.org/10.1093/database/bar041.

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20

Jung, S., N. Menda, S. Redmond, et al. "The Chado Natural Diversity module: a new generic database schema for large-scale phenotyping and genotyping data." Database 2011 (November 26, 2011): bar051. http://dx.doi.org/10.1093/database/bar051.

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21

Brose, Michelle. "Barely Breathing." Narrative Inquiry in Bioethics 10, no. 3 (2020): 202–5. http://dx.doi.org/10.1353/nib.2020.0057.

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22

Chesser, T., M. F. Gargan, and K. M. Willett. "'Barfly' injuries." BMJ 305, no. 6853 (1992): 583. http://dx.doi.org/10.1136/bmj.305.6853.583-b.

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23

Compton, Tony. "Barely literate." New Scientist 210, no. 2808 (2011): 31. http://dx.doi.org/10.1016/s0262-4079(11)60863-4.

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24

Maynard, Jake. "Barely Runnable." Appalachian Heritage 46, no. 2 (2018): 48–59. http://dx.doi.org/10.1353/aph.2018.0004.

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25

Coylewright, Megan, and Alexander M. Kowal. "Barely Contained." American Journal of Medicine 122, no. 6 (2009): 525–27. http://dx.doi.org/10.1016/j.amjmed.2009.03.007.

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26

Anderson, D. "Barely the Moon." Iowa Journal of Literary Studies 10, no. 1 (1989): 124. http://dx.doi.org/10.17077/0743-2747.1312.

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27

Peters, Tom. "Prometheus barely unbound." Academy of Management Perspectives 4, no. 4 (1990): 70–84. http://dx.doi.org/10.5465/ame.1990.4277211.

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28

Fingerhut, L. A. "The Barell matrix." Injury Prevention 8, no. 3 (2002): 259. http://dx.doi.org/10.1136/ip.8.3.259.

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29

Magriel, Nicolas. "The Barhat Tree." Asian Music 28, no. 2 (1997): 109. http://dx.doi.org/10.2307/834476.

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30

Sampson, Fred. "Managing, just barely." Interactions 14, no. 1 (2007): 10–11. http://dx.doi.org/10.1145/1189976.1189986.

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31

Goodall, Christopher. "Managing, but barely coping." Nursing Standard 8, no. 5 (1993): 51. http://dx.doi.org/10.7748/ns.8.5.51.s63.

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32

Holsti, Kal J., Jack Snyder, and Robert Jervis. "Barely Coping with Complexity." Mershon International Studies Review 38, no. 2 (1994): 285. http://dx.doi.org/10.2307/222726.

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33

Black, Donald D. "The Barkly West Declaration." Baptist Quarterly 34, no. 1 (1991): 43–45. http://dx.doi.org/10.1080/0005576x.1991.11751855.

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34

SENNETT, EDWARD J. "Fred C. Barald, MD." Radiology 181, no. 2 (1991): 609. http://dx.doi.org/10.1148/radiology.181.2.609-a.

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35

Christie, Christina A. "Interview With Eric Barela." American Journal of Evaluation 29, no. 4 (2008): 534–46. http://dx.doi.org/10.1177/1098214008328409.

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36

Currie, J. R. "Impossible Reconciliations (Barely Heard)." Music and Letters 88, no. 1 (2006): 121–33. http://dx.doi.org/10.1093/ml/gcl075.

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37

Vinik, A. I. "Barely Scratching the Surface." Diabetes Care 33, no. 1 (2009): 210–12. http://dx.doi.org/10.2337/dc09-2035.

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38

Shampo, Marc A., and Robert A. Kyle. "Charles Barkla—Nobel Laureate." Mayo Clinic Proceedings 68, no. 12 (1993): 1176. http://dx.doi.org/10.1016/s0025-6196(12)60068-8.

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39

Anagnostopoulou, Vlasia, Susmit Biswas, Heba Saadeldeen, et al. "Barely alive memory servers." ACM Journal on Emerging Technologies in Computing Systems 8, no. 4 (2012): 1–20. http://dx.doi.org/10.1145/2367736.2367742.

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40

Membrey, Conducted by Jill. "Interview with Peter Barham." Physics Education 35, no. 2 (2000): 139–42. http://dx.doi.org/10.1088/0031-9120/35/2/312.

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41

Ophir, Adi. "A Barely Visible Protagonist." differences 26, no. 2 (2015): 106–20. http://dx.doi.org/10.1215/10407391-3146009.

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42

Hogg, D. W. "A Barely Tested Hypothesis." Science 286, no. 5445 (1999): 1679b—1679. http://dx.doi.org/10.1126/science.286.5445.1679b.

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43

Stephens, Richard. "On barely continuous functions." International Journal of Mathematics and Mathematical Sciences 11, no. 4 (1988): 695–99. http://dx.doi.org/10.1155/s0161171288000845.

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The term barely continuous is a topological generalization of Baire-1according toF. Gerlits of the Mathematical Institute of the Hungarian Academy of Sciences, and thus worthy of further study. This paper compares barely continuous functions and continuous functions on an elementary level. Knowing how the continuity of the identity function between topologies on a given set yields the lattice structure for those topologies, the barely continuity of the identity function between topologies on a given set is investigated and used to add to the structure of that lattice. Included are certain subl

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44

Kuzucuoğlu, M. "Barely transitive permutation groups." Archiv der Mathematik 55, no. 6 (1990): 521–32. http://dx.doi.org/10.1007/bf01191686.

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45

Loudon, Michael F. "The 'Barely Veiled Warning'." JAMA: The Journal of the American Medical Association 259, no. 7 (1988): 1019. http://dx.doi.org/10.1001/jama.1988.03720070023027.

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46

Loudon, M. F. "The 'barely veiled warning'." JAMA: The Journal of the American Medical Association 259, no. 7 (1988): 1019–20. http://dx.doi.org/10.1001/jama.259.7.1019.

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47

Yamana, Shoji. "Sense of Guilt Barely Dodged:." International Journal of Human Culture Studies 2016, no. 26 (2016): 551–71. http://dx.doi.org/10.9748/hcs.2016.551.

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48

Singh Patel, Anand. "FOLK ARTS OF BARELA TRIBE." International Journal of Research -GRANTHAALAYAH 7, no. 11 (2019): 165–71. http://dx.doi.org/10.29121/granthaalayah.v7.i11.2019.3730.

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Tribal traditional arts are associated with some rituals and festivals. The arts prevalent in the folk, which involve deep process and growth of rituals, are folk arts that should be made as demonstrators. The display has full potential. They should try to give a demonstrative look. आदिवासी पारम्परिक कलाएँ किसी न किसी अनुष्ठान और पर्व.उत्सव से जुड़ी रहती है।लोक में प्रचलित कलाएँ जिनमें अनुष्ठान की गहरी प्रक्रिया और वृद्धि निहित होती है ऐसी लोक कलाएँ जो प्रदर्शनकारी के रूप में बनायी जानी चाहिए।ऐसी विधाएँ जिनमें अनुष्ठान बहुत कम हैं जिनमें प्रदर्शन की पूरी क्षमता है। उन्हें ही प्रदर्शनकारी

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49

Downey, Rod, Geoffrey Laforte, and Steffen Lempp. "A set with barely degree." Journal of Symbolic Logic 64, no. 4 (1999): 1700–1718. http://dx.doi.org/10.2307/2586807.

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50

Day, Andy. "Buildering: barely even a thing." Journal of Public Space 2, no. 1 (2017): 147. http://dx.doi.org/10.5204/jps.v2i1.57.

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<p>Often frivolous and whimsical, urban climbing has a rich history. Contrary to popular assumption, the phenomenon is neither an offshoot of parkour nor a by-product of the recent trend of rooftop exploration and its resultant photography. Whilst it overlaps extensively, urban climbing has its own characteristics, community and style. <br />Contemporary exponents often use the term <em>buildering</em>, a portmanteau of 'buildings' and 'bouldering', the latter being a discipline of climbing that focuses on short, difficult ascents that require powerful moves. Many sport

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