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Journal articles on the topic 'Basal ganglia-thalamo-cortical circuit'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Dirkx, Michiel F., Heidemarie Zach, Annelies J. van Nuland, Bastiaan R. Bloem, Ivan Toni, and Rick C. Helmich. "Cognitive load amplifies Parkinson’s tremor through excitatory network influences onto the thalamus." Brain 143, no. 5 (2020): 1498–511. http://dx.doi.org/10.1093/brain/awaa083.

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Abstract Parkinson’s tremor is related to cerebral activity in both the basal ganglia and a cerebello-thalamo-cortical circuit. It is a common clinical observation that tremor markedly increases during cognitive load (such as mental arithmetic), leading to serious disability. Previous research has shown that this tremor amplification is associated with reduced efficacy of dopaminergic treatment. Understanding the mechanisms of tremor amplification and its relation to catecholamines might help to better control this symptom with a targeted therapy. We reasoned that, during cognitive load, tremo

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Pasquini, M., G. Fabbrini, G. Moretti, et al. "Bradykinesia and Mental Slowness in Patients with Obsessive-compulsive Disorder." European Psychiatry 24, S1 (2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)71268-4.

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Background:Clinical and experimental findings suggest that Obsessive-Compulsive Disorder (OCD) is due to an abnormality of the cortico-striato-thalamo-cortical circuit. Bradykinesia and mental slowness can be present in patients with basal ganglia disorders affecting the cortico-striato-thalamo-cortical circuit. Aim of this study is to investigate whether bradykinesia and mental slowness are present in patients with OCD.Methods:Participants comprised 19 non-depressed anti-psychotic free patients with OCD.Bradykinesia was assessed with the motor section of the Unified Parkinson's Disease Rating

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Spraker, Matthew B., Hong Yu, Daniel M. Corcos, and David E. Vaillancourt. "Role of Individual Basal Ganglia Nuclei in Force Amplitude Generation." Journal of Neurophysiology 98, no. 2 (2007): 821–34. http://dx.doi.org/10.1152/jn.00239.2007.

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The basal ganglia-thalamo-cortical loop is an important neural circuit that regulates motor control. A key parameter that the nervous system regulates is the level of force to exert against an object during tasks such as grasping. Previous studies indicate that the basal ganglia do not exhibit increased activity with increasing amplitude of force, although these conclusions are based mainly on the putamen. The present study used functional magnetic resonance imaging to investigate which regions in the basal ganglia, thalamus, and motor cortex display increased activity when producing pinch-gri

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Igarashi, Jun, Osamu Shouno, Jan Moren, Junichiro Yoshimoto, and Kenji Doya. "A Spiking Neural Network Model of the Basal Ganglia-thalamo-cortical Circuit toward Understanding of Motor Symptoms of Parkinson Disease." Brain & Neural Networks 22, no. 3 (2015): 103–11. http://dx.doi.org/10.3902/jnns.22.103.

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Civier, Oren, Daniel Bullock, Ludo Max, and Frank H. Guenther. "Computational modeling of stuttering caused by impairments in a basal ganglia thalamo-cortical circuit involved in syllable selection and initiation." Brain and Language 126, no. 3 (2013): 263–78. http://dx.doi.org/10.1016/j.bandl.2013.05.016.

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Singer, Harvey S., and Farhan Augustine. "The Pathophysiology of Tics; An Evolving Story." Current Drug Therapy 15, no. 2 (2020): 92–123. http://dx.doi.org/10.2174/1574885514666191121143930.

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Background: Tics, defined as quick, rapid, sudden, recurrent, non-rhythmic motor movements or vocalizations are required components of Tourette Syndrome (TS) - a complex disorder characterized by the presence of fluctuating, chronic motor and vocal tics, and the presence of co-existing neuropsychological problems. Despite many advances, the underlying pathophysiology of tics/TS remains unknown. Objective: To address a variety of controversies surrounding the pathophysiology of TS. More specifically: 1) the configuration of circuits likely involved; 2) the role of inhibitory influences on motor

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Merchant, Hugo, Jessica Grahn, Laurel Trainor, Martin Rohrmeier, and W. Tecumseh Fitch. "Finding the beat: a neural perspective across humans and non-human primates." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1664 (2015): 20140093. http://dx.doi.org/10.1098/rstb.2014.0093.

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Humans possess an ability to perceive and synchronize movements to the beat in music (‘beat perception and synchronization’), and recent neuroscientific data have offered new insights into this beat-finding capacity at multiple neural levels. Here, we review and compare behavioural and neural data on temporal and sequential processing during beat perception and entrainment tasks in macaques (including direct neural recording and local field potential (LFP)) and humans (including fMRI, EEG and MEG). These abilities rest upon a distributed set of circuits that include the motor cortico-basal-gan

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Jiang, S., C. Luo, J. Gong, et al. "Aberrant Thalamocortical Connectivity in Juvenile Myoclonic Epilepsy." International Journal of Neural Systems 28, no. 01 (2017): 1750034. http://dx.doi.org/10.1142/s0129065717500344.

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The purpose of this study was to investigate the functional connectivity (FC) of thalamic subdivisions in patients with juvenile myoclonic epilepsy (JME). Resting state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data were acquired from 22 JME and 25 healthy controls. We first divided the thalamus into eight subdivisions by performing independent component analysis on tracking fibers and clustering thalamus-related FC maps. We then analyzed abnormal FC in each subdivision in JME compared with healthy controls, and we investigated their associations with clin

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Bokor, Gyula, and Peter D. Anderson. "Obsessive–Compulsive Disorder." Journal of Pharmacy Practice 27, no. 2 (2014): 116–30. http://dx.doi.org/10.1177/0897190014521996.

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Obsessive–compulsive disorder (OCD) is a common heterogeneous psychiatric disorder manifesting with obsessions and compulsions. Obsessions are intrusive, recurrent, and persistent unwanted thoughts. Compulsions are repetitive behaviors or mental acts that an individual feels driven to perform in response to the obsessions. The heterogeneity of OCD includes themes of obsessions, types of rituals, presence or absence of tics, etiology, genetics, and response to pharmacotherapy. Complications of OCD include interpersonal difficulties, unemployment, substance abuse, criminal justice issues, and ph

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Ullsperger, Markus, and D. Yves von Cramon. "The Role of Intact Frontostriatal Circuits in Error Processing." Journal of Cognitive Neuroscience 18, no. 4 (2006): 651–64. http://dx.doi.org/10.1162/jocn.2006.18.4.651.

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The basal ganglia have been suggested to play a key role in performance monitoring and resulting behavioral adjustments. It is assumed that the integration of prefrontal and motor cortico—striato—thalamo—cortical circuits provides contextual information to the motor anterior cingulate cortex regions to enable their function in performance monitoring. So far, direct evidence is missing, however. We addressed the involvement of frontostriatal circuits in performance monitoring by collecting event-related brain potentials (ERPs) and behavioral data in nine patients with focal basal ganglia lesion

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Yin, Y., Y. Yuan, L. Fan, C. Xie, and Z. Zhang. "Intrinsic functional connectivity of cortico-basal ganglia-thalamo-cortical circuitry underlying psychomotor retardation in major depressive disorder." European Psychiatry 41, S1 (2017): S328. http://dx.doi.org/10.1016/j.eurpsy.2017.02.262.

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IntroductionPsychomotor retardation (PMR) in depression is analogous to the hypokinesia in Parkinson's disease, which is associated with the unbalanced direct and indirect pathways of cortico-basal ganglia-thalamo-cortical (CBTC) circuitry. This study hypothesized PMR in major depressive disorder (MDD) should be associated with the hyperactivity of CBTC indirect pathways.ObjectivesTo substantiate the hypothesis that the PMR symptom of MDD might attribute to the hyperactivity of the ortico-basal ganglia-thalamo-cortical indirect pathway which could inhibit psychomotor performance.MethodsWe inve

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Steullet, Pascal, Jan-Harry cabungcal, Ines Khadimallah, et al. "Oxidative Stress Affects Prefrontal-Basal Ganglia-Thalamo-Cortical Circuits Involved in Selected Attention." Biological Psychiatry 87, no. 9 (2020): S32—S33. http://dx.doi.org/10.1016/j.biopsych.2020.02.106.

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13

Wang, Anqin, Hongli Wu, Chunsheng Xu, et al. "Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging." Neural Plasticity 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/7323121.

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Wilson’s disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and 30 age- and sex-matched healthy volunteers were recruited to accept diffusion-weighted images with 15 gradient vectors and conventional magnetic resonance imaging (MRI). The DTI parameters, including fractional anisotropy (FA) and mean diffusion (MD), were calculated by diffusion kurtosis estimator

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Feil, Katharina, Marion Huber, Nicolina Goldschagg, and Lars Kellert. "Unilateral Asterixis in Arm and Leg Caused by Internal Capsula Stroke." Case Reports in Neurological Medicine 2018 (2018): 1–3. http://dx.doi.org/10.1155/2018/3946380.

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We report an unusual clinical manifestation of ischemic stroke with acute right-sided asterixis affecting the arm as well as the leg due to a lesion in the left posterior limb of the internal capsula. After treatment with intravenous thrombolysis the patient made a good recovery. Notably, in this case unilateral asterixis affected the arm as well as the leg, resulting in postural and gait instability. In addition, damage in the basal ganglia-thalamo-cortical network, as in our patient, has to be distinguished from other supratentorial causes of acute asterixis like thalamic or frontal lobe les

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Tuleasca, Constantin, Thomas A. W. Bolton, Jean Régis, et al. "Normalization of aberrant pretherapeutic dynamic functional connectivity of extrastriate visual system in patients who underwent thalamotomy with stereotactic radiosurgery for essential tremor: a resting-state functional MRI study." Journal of Neurosurgery 132, no. 6 (2020): 1792–801. http://dx.doi.org/10.3171/2019.2.jns183454.

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OBJECTIVE The tremor circuitry has commonly been hypothesized to be driven by one or multiple pacemakers within the cerebello-thalamo-cortical pathway, including the cerebellum, contralateral motor thalamus, and primary motor cortex. However, previous studies, using multiple methodologies, have advocated that tremor could be influenced by changes within the right extrastriate cortex, at both the structural and functional level. The purpose of this work was to evaluate the role of the extrastriate cortex in tremor generation and further arrest after left unilateral stereotactic radiosurgery tha

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Ganguly, Jacky, Dinkar Kulshreshtha, Mohammed Almotiri, and Mandar Jog. "Muscle Tone Physiology and Abnormalities." Toxins 13, no. 4 (2021): 282. http://dx.doi.org/10.3390/toxins13040282.

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The simple definition of tone as the resistance to passive stretch is physiologically a complex interlaced network encompassing neural circuits in the brain, spinal cord, and muscle spindle. Disorders of muscle tone can arise from dysfunction in these pathways and manifest as hypertonia or hypotonia. The loss of supraspinal control mechanisms gives rise to hypertonia, resulting in spasticity or rigidity. On the other hand, dystonia and paratonia also manifest as abnormalities of muscle tone, but arise more due to the network dysfunction between the basal ganglia and the thalamo-cerebello-corti

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Jahanshahi, Marjan, and John C. Rothwell. "Inhibitory dysfunction contributes to some of the motor and non-motor symptoms of movement disorders and psychiatric disorders." Philosophical Transactions of the Royal Society B: Biological Sciences 372, no. 1718 (2017): 20160198. http://dx.doi.org/10.1098/rstb.2016.0198.

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Recently, it has been proposed that similar to goal-directed and habitual action mediated by the fronto-striatal circuits, the fronto-striato-subthalamic-pallidal-thalamo-cortical network may also mediate goal-directed and habitual (automatic) inhibition in both the motor and non-motor domains. Within this framework, some of the clinical manifestations of Parkinson's disease, dystonia, Tourette syndrome and obsessive–compulsive disorder can be considered to represent an imbalance between goal-directed and habitual action and inhibition. It is possible that surgical interventions targeting the

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Chandran, Arjun S., Stuti Joshi, Megan Thorburn, Rick Stell, and Christopher R. P. Lind. "Dystonic tics induced by deep brain stimulation of the posterior subthalamic area for essential tremor." Journal of Neurosurgery 126, no. 2 (2017): 386–90. http://dx.doi.org/10.3171/2015.12.jns15915.

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OBJECTIVE The posterior subthalamic area (PSA) is a promising target of deep brain stimulation (DBS) for medication-refractory essential tremor (ET). This case series describes a novel adverse effect manifesting as dystonic tics in patients with ET undergoing DBS of the PSA. METHODS Six patients with ET received electrode implants for DBS of the dorsal and caudal zona incerta subregions of the PSA. RESULTS Five of the 6 patients developed dystonic tics soon after clinical programming. These tics were of varying severity and required reduction of the electrical stimulation amplitude. This reduc

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Schmidt, Timo T., Ellis Rea, Julia Shababi-Klein, George Panagis, and Christine Winter. "Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive–compulsive disorder." International Journal of Neuropsychopharmacology 16, no. 5 (2013): 1083–91. http://dx.doi.org/10.1017/s1461145712000983.

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Abstract The underlying neurobiology of addictive or repetitive behaviours, such as obsessive–compulsive disorder (OCD), involves dopaminergic dysregulation. While addictive behaviour depends strongly on mesolimbocortical dopaminergic responses, repetitive behaviours have been associated with dopaminergic dysregulation in the basal ganglia–thalamo–cortical circuitry. The present study investigates differences in brain stimulation reward in rats with quinpirole-induced compulsive checking behaviour, in order to examine if deficits in reward processing are also relevant for OCD. Rats were tested

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Veniero, D., V. Ponzo, M. Stampanoni Bassi, et al. "P382: Cerebello-thalamo-cortical circuits and basal ganglia interactions in Parkinson’s patients with bilaterally implanted deep brain stimulating electrodes into subthalamic nuclei." Clinical Neurophysiology 125 (June 2014): S150. http://dx.doi.org/10.1016/s1388-2457(14)50491-9.

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21

Nakahara, Hiroyuki, Kenji Doya, and Okihide Hikosaka. "Parallel Cortico-Basal Ganglia Mechanisms for Acquisition and Execution of Visuomotor Sequences—A Computational Approach." Journal of Cognitive Neuroscience 13, no. 5 (2001): 626–47. http://dx.doi.org/10.1162/089892901750363208.

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Experimental studies have suggested that many brain areas, including the basal ganglia (BG), contribute to procedural learning. Focusing on the basal ganglia-thalamo-cortical (BG-TC) system, we propose a computational model to explain how different brain areas work together in procedural learning. The BG-TC system is composed of multiple separate loop circuits. According to our model, two separate BG-TC loops learn a visuomotor sequence concurrently but using different coordinates, one visual, and the other motor. The visual loop includes the dorsolateral prefrontal (DLPF) cortex and the anter

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Yin, Y., and Y. Yuan. "The Dopaminergic Polymorphisms in Psychomotor Retardation of Depression: A Pathway-based Imaging Genetics Association Study." European Psychiatry 41, S1 (2017): S145—S146. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1989.

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IntroductionSeveral lines of evidence implicate dopamine is involved in the psychomotor retardation (PMR) in major depressive disorder (MDD). Besides, abnormal cerebral blood flow (CBF) of PMR was also found in the cortico-basal ganglia-thalamo-cortical (CBTC) circuitry. We hypothesize that the polymorphisms of the dopaminergic pathway should be associated the abnormal CBF in the CBTC circuitry.ObjectiveTo investigate the association of the polymorphisms throughout the dopaminergic pathway with the cerebral blood flow (CBF) of PMR in MDD.MethodsThe blood sample of 63 patients (23 PMR, 40 NPMR)

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Pidoux, Ludivine, Pascale Le Blanc, Carole Levenes, and Arthur Leblois. "A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning." eLife 7 (July 25, 2018). http://dx.doi.org/10.7554/elife.32167.

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Speech is a complex sensorimotor skill, and vocal learning involves both the basal ganglia and the cerebellum. These subcortical structures interact indirectly through their respective loops with thalamo-cortical and brainstem networks, and directly via subcortical pathways, but the role of their interaction during sensorimotor learning remains undetermined. While songbirds and their song-dedicated basal ganglia-thalamo-cortical circuitry offer a unique opportunity to study subcortical circuits involved in vocal learning, the cerebellar contribution to avian song learning remains unknown. We d

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Kitchenham, Lindsey, and Georgia J. Mason. "Contribution to the special issue on clinical ethology: The neurobiology of environmentally induced stereotypic behaviours in captive animals: assessing the basal ganglia pathways and cortico-striatal-thalamo-cortical circuitry hypotheses." Behaviour, April 9, 2021, 1–52. http://dx.doi.org/10.1163/1568539x-bja10084.

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Abstract The neurobiology of environmentally induced stereotypic behaviours (SBs) (e.g., pacing in zoo carnivores, crib-biting in horses, tail chasing in dogs) is hypothesized to involve altered functioning within the basal ganglia (‘Basal Ganglia (BG) Pathways Hypotheses’) and/or between the basal ganglia and cortex (‘Cortico-Striatal-Thalamo-Cortical (CSTC) Circuits Hypotheses’). We review four decades of relevant studies, critically assessing support for both hypotheses. Currently no BG Pathways or CSTC Circuits hypothesis is fully supported. While some results are partially consistent with

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Lintas, Alessandra, Raudel Sánchez-Campusano, Alessandro E. P. Villa, Agnès Gruart, and José M. Delgado-García. "Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-82519-3.

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AbstractAltered functioning of GABAergic interneurons expressing parvalbumin (PV) in the basal ganglia-thalamo-cortical circuit are likely to be involved in several human psychiatric disorders characterized by deficits in attention and sensory gating with dysfunctional decision-making behavior. However, the contribution of these interneurons in the ability to acquire demanding learning tasks remains unclear. Here, we combine an operant conditioning task with local field potentials simultaneously recorded in several nuclei involved in reward circuits of wild-type (WT) and PV-deficient (PVKO) mi

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Wu, Chengyuan, Thomas Foltynie, Patricia Limousin, Ludvic Zrinzo, and Harith Akram. "Distributed Global Functional Connectivity Networks Predict Responsiveness to L-DOPA and Subthalamic Deep Brain Stimulation." Neurosurgery 66, Supplement_1 (2019). http://dx.doi.org/10.1093/neuros/nyz310_147.

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Abstract INTRODUCTION Brain circuit dysfunction in Parkinson's disease (PD) involves an extensive global network. A distinctive basal ganglia resting-state functional connectivity (rsFC) pattern has been linked with the ranked response to L-DOPA. We therefore sought to investigate global rsFC patterns associated with response to L-DOPA and to subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with advanced PD. METHODS A total of 19 patients underwent 3-Tesla resting-state functional magnetic resonance imaging (rsfMRI) in the ON-medication state prior to STN DBS. Improvement in

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Navarro-López, Eva M., Utku Çelikok, and Neslihan S. Şengör. "A dynamical model for the basal ganglia-thalamo-cortical oscillatory activity and its implications in Parkinson’s disease." Cognitive Neurodynamics, November 25, 2020. http://dx.doi.org/10.1007/s11571-020-09653-y.

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AbstractWe propose to investigate brain electrophysiological alterations associated with Parkinson’s disease through a novel adaptive dynamical model of the network of the basal ganglia, the cortex and the thalamus. The model uniquely unifies the influence of dopamine in the regulation of the activity of all basal ganglia nuclei, the self-organised neuronal interdependent activity of basal ganglia-thalamo-cortical circuits and the generation of subcortical background oscillations. Variations in the amount of dopamine produced in the neurons of the substantia nigra pars compacta are key both in

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Alejandro Manosalva, Herbert. "Double Hit Theory for the Development of Vascular Parkinsonism." Neurophysiology and Rehabilitation, June 15, 2019, 42–46. http://dx.doi.org/10.33805/2641-8991.120.

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Introduction: Identify the non-decoded network in Vascular Parkinsonism (VasP). Objective: To determine what pattern of stroke lesions is responsible for VasP, as compared to those patients who had stroke, gait and balance problems, but absence of a hypokinetic rigid syndrome also called Vascular Pseudo Parkinsonism-V PSeuP. Materials and Methods: Design: prospective cohort study. Participants were consecutively screened for parkinsonian symptoms during a year as according to our previous study. Validated questionnaire (Tanner Questionnaire-TQ) was used, and a new scale operationalizing the cr

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Loens, Sebastian, Julius Verrel, Vera-Maria Herrmann, et al. "Motor learning deficits in cervical dystonia point to defective basal ganglia circuitry." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-86513-7.

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AbstractDystonia is conceptualized as a network disorder involving basal ganglia, thalamus, sensorimotor cortex and the cerebellum. The cerebellum has been implicated in dystonia pathophysiology, but studies testing cerebellar function in dystonia patients have provided equivocal results. This study aimed to further elucidate motor network deficits in cervical dystonia with special interest in the role of the cerebellum. To this end we investigated motor learning tasks, that differ in their dependence on cerebellar and basal ganglia functioning. In 18 cervical dystonia patients and 18 age matc

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"Treatment mechanisms: traditional and new antipsychotic drugs." From Research to Treatment in Clinical Neuroscience 2, no. 3 (2000): 281–86. http://dx.doi.org/10.31887/dcns.2000.2.3/ctamminga.

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The first generation of antipsychotic drugs was discovered in the 1960s and 1970s, These agents were effective in treating psychosis, but were accompanied by significant side effects, including severe parkinsonism and akathisia. Second-generation antipsychotics were introduced in the 1990s, These drugs have at least equal efficacy to their predecessors, but far fewer side effects. Some data suggest a broader efficacy profile. Clozapine remains the only superior antipsychotic in terms of the magnitude of psychotic symptom reduction. Clinical and animal studies are consistent in suggesting that

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Guerra, Andrea, Donato Colella, Margherita Giangrosso, et al. "Driving motor cortex oscillations modulates bradykinesia in Parkinson’s disease." Brain, July 10, 2021. http://dx.doi.org/10.1093/brain/awab257.

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Abstract In Parkinson’s disease (PD) patients, beta (β) and gamma (γ) oscillations are altered in the basal ganglia, and this abnormality contributes to the pathophysiology of bradykinesia. However, it is unclear whether β and γ rhythms at the primary motor cortex (M1) level influence bradykinesia. Transcranial alternating current stimulation (tACS) can modulate cortical rhythms by entraining endogenous oscillations. We tested whether β- and γ-tACS on M1 modulate bradykinesia in PD patients by analyzing the kinematic features of repetitive finger tapping, including movement amplitude, velocity

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Atherton, Jeremy F., Eileen L. McIver, Matthew RM Mullen, David L. Wokosin, D. James Surmeier, and Mark D. Bevan. "Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease." eLife 5 (December 20, 2016). http://dx.doi.org/10.7554/elife.21616.

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The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To explore this potential linkage, the STN was studied in BAC transgenic and Q175 knock-in mouse models of HD. At <2 and 6 months of age autonomous STN activity was impaired due to activation of KATP channels. STN neurons exhibited prolonged NMDA receptor-mediated synaptic currents, caused by a deficit in glutamate uptake, and elevated mitochondria

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