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Journal articles on the topic 'Basal radial glia cell'

Author: Grafiati

Published: 25 May 2024

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1

Pereida-Jaramillo, Elizabeth, Gabriela B. Gómez-González, Angeles Edith Espino-Saldaña, and Ataúlfo Martínez-Torres. "Calcium Signaling in the Cerebellar Radial Glia and Its Association with Morphological Changes during Zebrafish Development." International Journal of Molecular Sciences 22, no. 24 (2021): 13509. http://dx.doi.org/10.3390/ijms222413509.

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Radial glial cells are a distinct non-neuronal cell type that, during development, span the entire width of the brain walls of the ventricular system. They play a central role in the origin and placement of neurons, since their processes form structural scaffolds that guide and facilitate neuronal migration. Furthermore, glutamatergic signaling in the radial glia of the adult cerebellum (i.e., Bergmann glia), is crucial for precise motor coordination. Radial glial cells exhibit spontaneous calcium activity and functional coupling spread calcium waves. However, the origin of calcium activity in

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2

Li, Zhen, William A. Tyler, Ella Zeldich, et al. "Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex." Science Advances 6, no. 45 (2020): eabd2068. http://dx.doi.org/10.1126/sciadv.abd2068.

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How the rich variety of neurons in the nervous system arises from neural stem cells is not well understood. Using single-cell RNA-sequencing and in vivo confirmation, we uncover previously unrecognized neural stem and progenitor cell diversity within the fetal mouse and human neocortex, including multiple types of radial glia and intermediate progenitors. We also observed that transcriptional priming underlies the diversification of a subset of ventricular radial glial cells in both species; genetic fate mapping confirms that the primed radial glial cells generate specific types of basal proge

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3

Moore, Rachel, and Paula Alexandre. "Delta-Notch Signaling: The Long and The Short of a Neuron’s Influence on Progenitor Fates." Journal of Developmental Biology 8, no. 2 (2020): 8. http://dx.doi.org/10.3390/jdb8020008.

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Maintenance of the neural progenitor pool during embryonic development is essential to promote growth of the central nervous system (CNS). The CNS is initially formed by tightly compacted proliferative neuroepithelial cells that later acquire radial glial characteristics and continue to divide at the ventricular (apical) and pial (basal) surface of the neuroepithelium to generate neurons. While neural progenitors such as neuroepithelial cells and apical radial glia form strong connections with their neighbours at the apical and basal surfaces of the neuroepithelium, neurons usually form the ma

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Kullmann, Jan A., Sophie Meyer, Fabrizia Pipicelli, et al. "Profilin1-Dependent F-Actin Assembly Controls Division of Apical Radial Glia and Neocortex Development." Cerebral Cortex 30, no. 6 (2019): 3467–82. http://dx.doi.org/10.1093/cercor/bhz321.

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Abstract Neocortex development depends on neural stem cell proliferation, cell differentiation, neurogenesis, and neuronal migration. Cytoskeletal regulation is critical for all these processes, but the underlying mechanisms are only poorly understood. We previously implicated the cytoskeletal regulator profilin1 in cerebellar granule neuron migration. Since we found profilin1 expressed throughout mouse neocortex development, we here tested the hypothesis that profilin1 is crucial for neocortex development. We found no evidence for impaired neuron migration or layering in the neocortex of prof

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Penisson, Maxime, Mingyue Jin, Shengming Wang, Shinji Hirotsune, Fiona Francis, and Richard Belvindrah. "Lis1 mutation prevents basal radial glia-like cell production in the mouse." Human Molecular Genetics 31, no. 6 (2021): 942–57. http://dx.doi.org/10.1093/hmg/ddab295.

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Abstract Human cerebral cortical malformations are associated with progenitor proliferation and neuronal migration abnormalities. Progenitor cells include apical radial glia, intermediate progenitors and basal (or outer) radial glia (bRGs or oRGs). bRGs are few in number in lissencephalic species (e.g. the mouse) but abundant in gyrencephalic brains. The LIS1 gene coding for a dynein regulator, is mutated in human lissencephaly, associated also in some cases with microcephaly. LIS1 was shown to be important during cell division and neuronal migration. Here, we generated bRG-like cells in the m

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Zhang, Sanguo, Huanhuan Joyce Wang, Jia Li, Xiao-Ling Hu, and Qin Shen. "Radial Glial Cell-Derived VCAM1 Regulates Cortical Angiogenesis Through Distinct Enrichments in the Proximal and Distal Radial Processes." Cerebral Cortex 30, no. 6 (2020): 3717–30. http://dx.doi.org/10.1093/cercor/bhz337.

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Abstract Angiogenesis in the developing cerebral cortex accompanies cortical neurogenesis. However, the precise mechanisms underlying cortical angiogenesis at the embryonic stage remain largely unknown. Here, we show that radial glia-derived vascular cell adhesion molecule 1 (VCAM1) coordinates cortical vascularization through different enrichments in the proximal and distal radial glial processes. We found that VCAM1 was highly enriched around the blood vessels in the inner ventricular zone (VZ), preventing the ingrowth of blood vessels into the mitotic cell layer along the ventricular surfac

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Shohayeb, Belal, Uda Ho, Yvonne Y. Yeap, et al. "The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development." Human Molecular Genetics 29, no. 2 (2019): 248–63. http://dx.doi.org/10.1093/hmg/ddz281.

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Abstract WDR62 mutations that result in protein loss, truncation or single amino-acid substitutions are causative for human microcephaly, indicating critical roles in cell expansion required for brain development. WDR62 missense mutations that retain protein expression represent partial loss-of-function mutants that may therefore provide specific insights into radial glial cell processes critical for brain growth. Here we utilized CRISPR/Cas9 approaches to generate three strains of WDR62 mutant mice; WDR62 V66M/V66M and WDR62R439H/R439H mice recapitulate conserved missense mutations found in h

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8

Golden, J. A., J. C. Zitz, K. McFadden, and C. L. Cepko. "Cell migration in the developing chick diencephalon." Development 124, no. 18 (1997): 3525–33. http://dx.doi.org/10.1242/dev.124.18.3525.

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We previously reported that retrovirally marked clones in the mature chick diencephalon were widely dispersed in the mediolateral, dorsoventral and rostrocaudal planes. The current study was undertaken to define the migration routes that led to the dispersion. Embryos were infected between stages 10 and 14 with a retroviral stock encoding alkaline phosphatase and a library of molecular tags. Embryos were harvested 2.5-5.5 days later and the brains were fixed and serially sectioned. Sibling relationships were determined following PCR amplification and sequencing of the molecular tag. On embryon

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9

Li, Xiaosu, Guoping Liu, Lin Yang, et al. "Decoding Cortical Glial Cell Development." Neuroscience Bulletin 37, no. 4 (2021): 440–60. http://dx.doi.org/10.1007/s12264-021-00640-9.

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AbstractMouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There are fundamental gaps in understanding how these diverse cell subtypes are generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show that beginning at around E16.5, neocortical RGCs start to generate ASCL1+EGFR+ apical multipotent intermediate progenitors (MIPCs), which then differentiate into basal MIPCs that express ASCL1, EGFR, OLIG2, and MKI67.

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10

Sawada, Kazuhiko. "Tracking of neurons derived from basal radial glia experiencing multiple cell division in the developing neocortex of ferrets." IBRO Reports 6 (September 2019): S84. http://dx.doi.org/10.1016/j.ibror.2019.07.272.

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11

Park, Seon Hye E., Ashwinikumar Kulkarni, and Genevieve Konopka. "FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells." PLOS Biology 21, no. 8 (2023): e3001852. http://dx.doi.org/10.1371/journal.pbio.3001852.

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During cortical development, human basal radial glial cells (bRGCs) are highly capable of sustained self-renewal and neurogenesis. Selective pressures on this cell type may have contributed to the evolution of the human neocortex, leading to an increase in cortical size. bRGCs have enriched expression for Forkhead Box P1 (FOXP1), a transcription factor implicated in neurodevelopmental disorders (NDDs) such as autism spectrum disorder. However, the cell type–specific roles of FOXP1 in bRGCs during cortical development remain unexplored. Here, we examine the requirement for FOXP1 gene expression

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Sahara, Setsuko, and Dennis D. M. O'Leary. "Fgf10 Regulates Transition Period of Cortical Stem Cell Differentiation to Radial Glia Controlling Generation of Neurons and Basal Progenitors." Neuron 63, no. 1 (2009): 48–62. http://dx.doi.org/10.1016/j.neuron.2009.06.006.

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13

Zhao, Xiang, Jason Q. Garcia, Kai Tong, et al. "Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division." Science Advances 7, no. 24 (2021): eabg1244. http://dx.doi.org/10.1126/sciadv.abg1244.

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In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling asymmetry between daughter cells during asymmetric cell division (ACD). How cortically localized Par-3 establishes asymmetric Notch activity in the nucleus is not understood. Here, using in vivo time-lapse imaging of mitotic radial glia progenitors in the developing zebrafish forebrain, we uncover that during horizontal ACD along the anteroposterior embryonic axis, endosomes containing the Notch ligand DeltaD (Dld) move toward the cleavage plane and preferentially segregate into the po

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Stier, H., and B. Schlosshauer. "Axonal guidance in the chicken retina." Development 121, no. 5 (1995): 1443–54. http://dx.doi.org/10.1242/dev.121.5.1443.

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During retina development, ganglion cells extend their axons exclusively into the innermost tissue layer, but not into outer retina layers. In order to elucidate guiding mechanisms for axons, tissue strips of embryonic chicken retinae were explanted onto retinal cryosections (cryoculture). Ganglion cell axons originating from the explant grew preferentially on the innermost retina layer of cryosections, whereas outer tissue layers were avoided, very much as in vivo. Stereotropism, interaction with laminin of the basal lamina and axonal fasciculation did not significantly affect oriented axonal

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Zaidi, Donia, Kaviya Chinnappa, and Fiona Francis. "Primary Cilia Influence Progenitor Function during Cortical Development." Cells 11, no. 18 (2022): 2895. http://dx.doi.org/10.3390/cells11182895.

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Corticogenesis is an intricate process controlled temporally and spatially by many intrinsic and extrinsic factors. Alterations during this important process can lead to severe cortical malformations. Apical neuronal progenitors are essential cells able to self-amplify and also generate basal progenitors and/or neurons. Apical radial glia (aRG) are neuronal progenitors with a unique morphology. They have a long basal process acting as a support for neuronal migration to the cortical plate and a short apical process directed towards the ventricle from which protrudes a primary cilium. This ante

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Moers, Alexandra, Alexander Nürnberg, Sandra Goebbels, Nina Wettschureck та Stefan Offermanns. "Gα12/Gα13 Deficiency Causes Localized Overmigration of Neurons in the Developing Cerebral and Cerebellar Cortices". Molecular and Cellular Biology 28, № 5 (2007): 1480–88. http://dx.doi.org/10.1128/mcb.00651-07.

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ABSTRACT The heterotrimeric G proteins G12 and G13 link G-protein-coupled receptors to the regulation of the actin cytoskeleton and the induction of actomyosin-based cellular contractility. Here we show that conditional ablation of the genes encoding the α-subunits of G12 and G13 in the nervous system results in neuronal ectopia of the cerebral and cerebellar cortices due to overmigration of cortical plate neurons and cerebellar Purkinje cells, respectively. The organization of the radial glia and the basal lamina was not disturbed, and the Cajal-Retzius cell layer had formed normally in mutan

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17

Loeb, J. A., T. S. Khurana, J. T. Robbins, A. G. Yee, and G. D. Fischbach. "Expression patterns of transmembrane and released forms of neuregulin during spinal cord and neuromuscular synapse development." Development 126, no. 4 (1999): 781–91. http://dx.doi.org/10.1242/dev.126.4.781.

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We mapped the distribution of neuregulin and its transmembrane precursor in developing, embryonic chick and mouse spinal cord. Neuregulin mRNA and protein were expressed in motor and sensory neurons shortly after their birth and levels steadily increased during development. Expression of the neuregulin precursor was highest in motor and sensory neuron cell bodies and axons, while soluble, released neuregulin accumulated along early motor and sensory axons, radial glia, spinal axonal tracts and neuroepithelial cells through associations with heparan sulfate proteoglycans. Neuregulin accumulatio

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18

D’Arcy, Brooke R., Ashley L. Lennox, Camila Manso Musso, et al. "Non-muscle myosins control radial glial basal endfeet to mediate interneuron organization." PLOS Biology 21, no. 2 (2023): e3001926. http://dx.doi.org/10.1371/journal.pbio.3001926.

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Radial glial cells (RGCs) are essential for the generation and organization of neurons in the cerebral cortex. RGCs have an elongated bipolar morphology with basal and apical endfeet that reside in distinct niches. Yet, how this subcellular compartmentalization of RGCs controls cortical development is largely unknown. Here, we employ in vivo proximity labeling, in the mouse, using unfused BirA to generate the first subcellular proteome of RGCs and uncover new principles governing local control of cortical development. We discover a cohort of proteins that are significantly enriched in RGC basa

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Rosenfeld, Amy B., David J. Doobin, Audrey L. Warren, Vincent R. Racaniello, and Richard B. Vallee. "Replication of early and recent Zika virus isolates throughout mouse brain development." Proceedings of the National Academy of Sciences 114, no. 46 (2017): 12273–78. http://dx.doi.org/10.1073/pnas.1714624114.

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Fetal infection with Zika virus (ZIKV) can lead to congenital Zika virus syndrome (cZVS), which includes cortical malformations and microcephaly. The aspects of cortical development that are affected during virus infection are unknown. Using organotypic brain slice cultures generated from embryonic mice of various ages, sites of ZIKV replication including the neocortical proliferative zone and radial columns, as well as the developing midbrain, were identified. The infected radial units are surrounded by uninfected cells undergoing apoptosis, suggesting that programmed cell death may limit vir

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Gray, J. A., G. Grigoryan, D. Virley, S. Patel, J. D. Sinden, and H. Hodges. "Conditionally Immortalized, Multipotential and Multifunctional Neural Stem Cell Lines as an Approach to Clinical Transplantation." Cell Transplantation 9, no. 2 (2000): 153–68. http://dx.doi.org/10.1177/096368970000900203.

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Experiments are described using rats with two kinds of brain damage and consequent cognitive deficit (in the Morris water maze, three-door runway, and radial maze): 1) ischemic damage to the CA1 hippocampal cell field after four-vessel occlusion (4VO), and 2) damage to the forebrain cholinergic projection system by local injection of excitotoxins to the nuclei of origin or prolonged ethanol administration. Cell suspension grafts derived from primary fetal brain tissue display a stringent requirement for homotypical cell replacement in the 4VO model: cells from the embryonic day (E)18–19 CA1 hi

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Pushchina, Evgeniya V., Maria E. Stukaneva, and Anatoly A. Varaksin. "Hydrogen Sulfide Modulates Adult and Reparative Neurogenesis in the Cerebellum of Juvenile Masu Salmon, Oncorhynchus masou." International Journal of Molecular Sciences 21, no. 24 (2020): 9638. http://dx.doi.org/10.3390/ijms21249638.

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Fish are a convenient model for the study of reparative and post-traumatic processes of central nervous system (CNS) recovery, because the formation of new cells in their CNS continues throughout life. After a traumatic injury to the cerebellum of juvenile masu salmon, Oncorhynchus masou, the cell composition of the neurogenic zones containing neural stem cells (NSCs)/neural progenitor cells (NPCs) in the acute period (two days post-injury) changes. The presence of neuroepithelial (NE) and radial glial (RG) neuronal precursors located in the dorsal, lateral, and basal zones of the cerebellar b

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Meyerink, Brandon L., Neeraj K. Tiwari, and Louis-Jan Pilaz. "Ariadne’s Thread in the Developing Cerebral Cortex: Mechanisms Enabling the Guiding Role of the Radial Glia Basal Process during Neuron Migration." Cells 10, no. 1 (2020): 3. http://dx.doi.org/10.3390/cells10010003.

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Radial neuron migration in the developing cerebral cortex is a complex journey, starting in the germinal zones and ending in the cortical plate. In mice, migratory distances can reach several hundreds of microns, or millimeters in humans. Along the migratory path, radially migrating neurons slither through cellularly dense and complex territories before they reach their final destination in the cortical plate. This task is facilitated by radial glia, the neural stem cells of the developing cortex. Indeed, radial glia have a unique bipolar morphology, enabling them to serve as guides for neuron

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Gray, G. E., and J. R. Sanes. "Lineage of radial glia in the chicken optic tectum." Development 114, no. 1 (1992): 271–83. http://dx.doi.org/10.1242/dev.114.1.271.

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In many parts of the central nervous system, the elongated processes of radial glial cells are believed to guide immature neurons from the ventricular zone to their sites of differentiation. To study the clonal relationships of radial glia to other neural cell types, we used a recombinant retrovirus to label precursor cells in the chick optic tectum with a heritable marker, the E. coli lacZ gene. The progeny of the infected cells were detected at later stages of development with a histochemical stain for the lacZ gene product. Radial glia were identified in a substantial fraction of clones, an

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Kriegstein, Arnold R., and Magdalena Götz. "Radial glia diversity: A matter of cell fate." Glia 43, no. 1 (2003): 37–43. http://dx.doi.org/10.1002/glia.10250.

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Beattie, Robert, and Simon Hippenmeyer. "Mechanisms of radial glia progenitor cell lineage progression." FEBS Letters 591, no. 24 (2017): 3993–4008. http://dx.doi.org/10.1002/1873-3468.12906.

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Dieriks, Birger Victor, Justin M. Dean, Eleonora Aronica, Henry J. Waldvogel, Richard L. M. Faull, and Maurice A. Curtis. "Differential Fatty Acid-Binding Protein Expression in Persistent Radial Glia in the Human and Sheep Subventricular Zone." Developmental Neuroscience 40, no. 2 (2018): 145–61. http://dx.doi.org/10.1159/000487633.

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Fatty acid-binding proteins (FABPs) are a family of transport proteins that facilitate intracellular transport of fatty acids. Despite abundant expression in the brain, the role that FABPs play in the process of cell proliferation and migration in the subventricular zone (SVZ) remains unclear. Our results provide a detailed characterisation of FABP3, 5, and 7 expression in adult and fetal human and sheep SVZ. High FABP5 expression was specifically observed in the adult human SVZ and co-labelled with polysialylated neural cell adhesion molecule (PSA-NCAM), glial fibrillary acidic protein (GFAP)

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Matsuoka, Ryota L., Andrea Rossi, Oliver A. Stone, and Didier Y. R. Stainier. "CNS-resident progenitors direct the vascularization of neighboring tissues." Proceedings of the National Academy of Sciences 114, no. 38 (2017): 10137–42. http://dx.doi.org/10.1073/pnas.1619300114.

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Organ growth requires the coordinated invasion and expansion of blood vessel networks directed by tissue-resident cells and morphogenetic cues. A striking example of this intercellular communication is the vascularization of the central nervous system (CNS), which is driven by neuronal progenitors, including neuroepithelial cells and radial glia. Although the importance of neuronal progenitors in vascular development within the CNS is well recognized, how these progenitors regulate the vasculature outside the CNS remains largely unknown. Here we show that CNS-resident radial glia direct the va

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Hevner, R. F., and T. F. Haydar. "The (Not Necessarily) Convoluted Role of Basal Radial Glia in Cortical Neurogenesis." Cerebral Cortex 22, no. 2 (2011): 465–68. http://dx.doi.org/10.1093/cercor/bhr336.

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Feng, L., and N. Heintz. "Differentiating neurons activate transcription of the brain lipid-binding protein gene in radial glia through a novel regulatory element." Development 121, no. 6 (1995): 1719–30. http://dx.doi.org/10.1242/dev.121.6.1719.

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Formation and maintenance of a radial glial scaffold is fundamental for development of the vertebrate central nervous system. In mammals, radial glia arise in the neuroepithelium immediately prior to differentiation and migration of neurons away from the ventricular zones, and they are maintained until neuronal migration subsides. We have previously shown that expression of the brain lipid-binding protein (BLBP) in radial glia throughout the developing CNS is strictly correlated with the differentiation and migration of neurons upon these cells, and that BLBP function is required to maintain d

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Malatesta, P., and M. Gotz. "Radial glia - from boring cables to stem cell stars." Development 140, no. 3 (2013): 483–86. http://dx.doi.org/10.1242/dev.085852.

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Nagashima, Mikiko, and Peter F. Hitchcock. "Inflammation Regulates the Multi-Step Process of Retinal Regeneration in Zebrafish." Cells 10, no. 4 (2021): 783. http://dx.doi.org/10.3390/cells10040783.

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The ability to regenerate tissues varies between species and between tissues within a species. Mammals have a limited ability to regenerate tissues, whereas zebrafish possess the ability to regenerate almost all tissues and organs, including fin, heart, kidney, brain, and retina. In the zebrafish brain, injury and cell death activate complex signaling networks that stimulate radial glia to reprogram into neural stem-like cells that repair the injury. In the retina, a popular model for investigating neuronal regeneration, Müller glia, radial glia unique to the retina, reprogram into stem-like c

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Kanatani, Shigeaki, Hidenori Tabata, and Kazunori Nakajima. "Topical Review: Neuronal Migration in Cortical Development." Journal of Child Neurology 19, no. 3 (2004): 274–79. http://dx.doi.org/10.1177/08830738040190030201.

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Cortical formation in the developing brain is a highly complicated process involving neuronal production (through symmetric or asymmetric cell division) interaction of radial glia with neuronal migration, and multiple modes of neuronal migration. It has been convincingly demonstrated by numerous studies that radial glial cells are neural stem cells. However, the processes by which neurons arise from radial glia and migrate to their final destinations in vivo are not yet fully understood. Recent studies using time-lapse imaging of neuronal migration are giving investigators an increasingly more

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Nodari, Alessandro, Desirée Zambroni, Angelo Quattrini та ін. "β1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination". Journal of Cell Biology 177, № 6 (2007): 1063–75. http://dx.doi.org/10.1083/jcb.200610014.

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Myelin is a multispiraled extension of glial membrane that surrounds axons. How glia extend a surface many-fold larger than their body is poorly understood. Schwann cells are peripheral glia and insert radial cytoplasmic extensions into bundles of axons to sort, ensheath, and myelinate them. Laminins and β1 integrins are required for axonal sorting, but the downstream signals are largely unknown. We show that Schwann cells devoid of β1 integrin migrate to and elongate on axons but cannot extend radial lamellae of cytoplasm, similar to cells with low Rac1 activation. Accordingly, active Rac1 is

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Kyrousi, Christina, Zoi Lygerou, and Stavros Taraviras. "How a radial glial cell decides to become a multiciliated ependymal cell." Glia 65, no. 7 (2017): 1032–42. http://dx.doi.org/10.1002/glia.23118.

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Kriho, V., H. Y. Yang, C. M. Lue, N. Lieska, and G. D. Pappas. "An Early Developmental Marker for Radial Glia in Rat Spinal Cord." Proceedings, annual meeting, Electron Microscopy Society of America 54 (August 11, 1996): 36–37. http://dx.doi.org/10.1017/s0424820100162648.

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Radial glia have been classically defined as those early glial cells that radially span their thin processes from the ventricular to the pial surfaces in the developing central nervous system. These radial glia constitute a transient cell population, disappearing, for the most part, by the end of the period of neuronal migration. Traditionally, it has been difficult to definitively identify these cells because the principal criteria available were morphologic only.Using immunofluorescence microscopy, we have previously defined a phenotype for radial glia in rat spinal cord based upon the seque

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Wong, Fong Kuan, Ji-Feng Fei, Felipe Mora-Bermúdez, et al. "Sustained Pax6 Expression Generates Primate-like Basal Radial Glia in Developing Mouse Neocortex." PLOS Biology 13, no. 8 (2015): e1002217. http://dx.doi.org/10.1371/journal.pbio.1002217.

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Berg, Daniel A., Allison M. Bond, Guo-li Ming, and Hongjun Song. "Radial glial cells in the adult dentate gyrus: what are they and where do they come from?" F1000Research 7 (March 5, 2018): 277. http://dx.doi.org/10.12688/f1000research.12684.1.

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Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively in

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Wang, Rong, Roshan Sharma, Xiaojuan Shen, et al. "Adult Human Glioblastomas Harbor Radial Glia-like Cells." Stem Cell Reports 15, no. 1 (2020): 275–77. http://dx.doi.org/10.1016/j.stemcr.2020.06.002.

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Wang, Rong, Roshan Sharma, Xiaojuan Shen, et al. "Adult Human Glioblastomas Harbor Radial Glia-like Cells." Stem Cell Reports 14, no. 2 (2020): 338–50. http://dx.doi.org/10.1016/j.stemcr.2020.01.007.

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Hartfuss, Eva, Rossella Galli, Nico Heins, and Magdalena Götz. "Characterization of CNS Precursor Subtypes and Radial Glia." Developmental Biology 229, no. 1 (2001): 15–30. http://dx.doi.org/10.1006/dbio.2000.9962.

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Liour, Sean S., Stacey A. Kraemer, Michael B. Dinkins, Chen-Ying Su, Makoto Yanagisawa, and Robert K. Yu. "Further characterization of embryonic stem cell-derived radial glial cells." Glia 53, no. 1 (2006): 43–56. http://dx.doi.org/10.1002/glia.20257.

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Gao, Xue-Ling, Wen-Jia Tian, Bofeng Liu, Jingyi Wu, Wei Xie, and Qin Shen. "High-mobility group nucleosomal binding domain 2 protects against microcephaly by maintaining global chromatin accessibility during corticogenesis." Journal of Biological Chemistry 295, no. 2 (2019): 468–80. http://dx.doi.org/10.1074/jbc.ra119.010616.

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The surface area of the human cerebral cortex undergoes dramatic expansion during late fetal development, leading to cortical folding, an evolutionary feature not present in rodents. Microcephaly is a neurodevelopmental disorder defined by an abnormally small brain, and many gene mutations have been found to be associated with primary microcephaly. However, mouse models generated by ablating primary microcephaly-associated genes often fail to recapitulate the severe loss of cortical surface area observed in individuals with this pathology. Here, we show that a mouse model with deficient expres

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Taylor, Michael D., Helen Poppleton, Christine Fuller, et al. "Radial glia cells are candidate stem cells of ependymoma." Cancer Cell 8, no. 4 (2005): 323–35. http://dx.doi.org/10.1016/j.ccr.2005.09.001.

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Taylor, Michael D., Helen Poppleton, Christine Fuller, et al. "Radial glia cells are candidate stem cells of ependymoma." Cancer Cell 9, no. 1 (2006): 70. http://dx.doi.org/10.1016/j.ccr.2005.12.023.

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Bilinovich, Stephanie M., Katie L. Uhl, Kristy Lewis, et al. "Integrated RNA Sequencing Reveals Epigenetic Impacts of Diesel Particulate Matter Exposure in Human Cerebral Organoids." Developmental Neuroscience 42, no. 5-6 (2020): 195–207. http://dx.doi.org/10.1159/000513536.

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Autism spectrum disorder (ASD) manifests early in childhood. While genetic variants increase risk for ASD, a growing body of literature has established that in utero chemical exposures also contribute to ASD risk. These chemicals include air-based pollutants like diesel particulate matter (DPM). A combination of single-cell and direct transcriptomics of DPM-exposed human-induced pluripotent stem cell-derived cerebral organoids revealed toxicogenomic effects of DPM exposure during fetal brain development. Direct transcriptomics, sequencing RNA bases via Nanopore, revealed that cerebral organoid

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Shtaya, Anan, Ahmed‐Ramadan Sadek, Malik Zaben, et al. "AMPA receptors and seizures mediate hippocampal radial glia‐like stem cell proliferation." Glia 66, no. 11 (2018): 2397–413. http://dx.doi.org/10.1002/glia.23479.

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Eze, Ugomma C., Aparna Bhaduri, Maximilian Haeussler, Tomasz J. Nowakowski, and Arnold R. Kriegstein. "Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia." Nature Neuroscience 24, no. 4 (2021): 584–94. http://dx.doi.org/10.1038/s41593-020-00794-1.

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AbstractThe human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the developing human brain, including the telencephalon, diencephalon, midbrain, hindbrain and cerebellum. We identify nine progenitor populations physically proximal to the telencephalon, suggesting more heterogeneity than previously described, including a highly prevalent mesenchymal-like populatio

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Zou, Jian, Ryan P. Vetreno та Fulton T. Crews. "ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation". Glia 60, № 4 (2012): 661–73. http://dx.doi.org/10.1002/glia.22302.

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Raphael, Alya R., David A. Lyons, and William S. Talbot. "ErbB signaling has a role in radial sorting independent of Schwann cell number." Glia 59, no. 7 (2011): 1047–55. http://dx.doi.org/10.1002/glia.21175.

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Vaid, Samir, J. Gray Camp, Lena Hersemann, et al. "A novel population of Hopx-dependent basal radial glial cells in the developing mouse neocortex." Development 145, no. 20 (2018): dev169276. http://dx.doi.org/10.1242/dev.169276.

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