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Academic literature on the topic 'Base pyrimidique'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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Journal articles on the topic "Base pyrimidique"

1

Montemayor, Eric J., Johanna M. Virta, Lauren D. Hagler, Steven C. Zimmerman, and Samuel E. Butcher. "Structure of an RNA helix with pyrimidine mismatches and cross-strand stacking." Acta Crystallographica Section F Structural Biology Communications 75, no. 10 (September 24, 2019): 652–56. http://dx.doi.org/10.1107/s2053230x19012172.

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The structure of a 22-base-pair RNA helix with mismatched pyrimidine base pairs is reported. The helix contains two symmetry-related CUG sequences: a triplet-repeat motif implicated in myotonic dystrophy type 1. The CUG repeat contains a U–U mismatch sandwiched between Watson–Crick pairs. Additionally, the center of the helix contains a dimerized UUCG motif with tandem pyrimidine (U–C/C–U) mismatches flanked by U–G wobble pairs. This region of the structure is significantly different from previously observed structures that share the same sequence and neighboring base pairs. The tandem pyrimidine mismatches are unusual and display sheared, cross-strand stacking geometries that locally constrict the helical width, a type of stacking previously associated with purines in internal loops. Thus, pyrimidine-rich regions of RNA have a high degree of structural diversity.

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Fairlamb, Max S., Amy M. Whitaker, and Bret D. Freudenthal. "Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5′ mismatches." Acta Crystallographica Section D Structural Biology 74, no. 8 (July 24, 2018): 760–68. http://dx.doi.org/10.1107/s2059798318003340.

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Despite the DNA duplex being central to biological functions, many intricacies of this molecule, including the dynamic nature of mismatched base pairing, are still unknown. The unique conformations adopted by DNA mismatches can provide insight into the forces at play between nucleotides. Moreover, DNA-binding proteins apply their own individualized steric and electrochemical influences on the nucleotides that they interact with, further altering base-pairing conformations. Here, seven X-ray crystallographic structures of the human nuclease apurinic/apyrimidinic (AP) endonuclease 1 (APE1) in complex with its substrate target flanked by a 5′ mismatch are reported. The structures reveal how APE1 influences the conformations of a variety of different mismatched base pairs. Purine–purine mismatches containing a guanine are stabilized by a rotation of the guanine residue about the N-glycosidic bond to utilize the Hoogsteen edge for hydrogen bonding. Interestingly, no rotation of adenine, the other purine, is observed. Mismatches involving both purine and pyrimidine bases adopt wobble conformations to accommodate the mismatch. Pyrimidine–pyrimidine mismatches also wobble; however, the smaller profile of a pyrimidine base results in a gap between the Watson–Crick faces that is reduced by a C1′–C1′ compression. These results advance our understanding of mismatched base pairing and the influence of a bound protein.

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Stasevych, Maryna, Svitlana Sabat, Rostyslav Musyanovych, and Volodymyr Novikov. "Synthesis of condensed S-, N- containing heterocyclic systems on the base of 2-amino-4,9-dioxo-4,9-dihydronaphto[2,3-b]thiophene-3-ethylcarboxilate." Chemistry & Chemical Technology 2, no. 3 (September 15, 2008): 157–62. http://dx.doi.org/10.23939/chcht02.03.157.

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Synthesis of a new 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones, 2-arylnaphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-4,5,10(3Н)-triones, 3-phenyl naphtho[2’,3’,4,5]thieno[2,3-d][1,3]pyrimidine-2,4,5,10(1Н, 3Н)-tetraone and 2-thioxo-2,3-dyhydronaphth[2’,3’,4,5]thieno[2,3-d]pyrimidine-4,5,10(1Н)-trione was carried out. The mechanism of 2-aryl-4Н-naphtho[2’,3’,4,5]thieno[2,3-d][1,3]oxazine-4,5,10-triones formation was suggested.

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Kadioglu, Ela, Semra Sardas, Meltem Ergun, Selahattin Unal, and Ali Esat Karakaya. "The role of oxidative DNA damage, DNA repair, GSTM1, SOD2 and OGG1 polymorphisms in individual susceptibility to Barrett’s esophagus." Toxicology and Industrial Health 26, no. 2 (January 7, 2010): 67–79. http://dx.doi.org/10.1177/0748233709359278.

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Determination of the genetic alterations, which play a role in the etiology of Barrett’s esophagus (BE), could help identify high-risk individuals for esophageal adenocarcinoma (EA). The aim of the present study was to investigate the role of oxidative DNA damage, glutathione (GSH) concentration as oxidative stress parameters and DNA repair capacity, GSTM1, SOD1 Ala16Val and OGG1 Ser326Cys genetic polymorphisms as individual susceptibility parameters in the etiology of BE. The study groups comprised BE patients who were clinically diagnosed (n = 40) and a healthy control group (n = 40). Basal DNA damage, pyrimidine and purine base damage after H2O2 induction, H 2O2 sensitivity, DNA repair capacity, oxidized pyrimidine and purine base damage repair were evaluated in peripheral blood lymphocytes with a modified comet assay using specific endonucleases (Endo III and Fpg). Polymerase chain reaction—restriction length polymorphism (PCR-RFLP)-based assays were used for genotyping. The patient group showed elevated levels of basal DNA damage, pyrimidine base damage and H2O2 sensitivity as compared to controls (p < .05). DNA repair capacity, oxidized pyrimidine and purine base damage repair capacity, were not statistically different between patients and controls. GSH concentration was found to be significantly lower in smoking patients than in the controls (p < .05). None of the genetic variations changed the risk of having BE disease. However, patients carrying the variant OGG1 Cys allele showed elevated levels of pyrimidine base damage as compared to patients carrying the wild-type OGG1 Ser (p < .05). The results of this study point to a role of oxidative DNA damage in BE. However, DNA repair capacity, GSTM1, SOD1 Ala16Val and OGG1 Ser326Cys genetic polymorphisms appeared to play no role in the individual susceptibility to this disease.

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Kouchakdjian, Michael, Benjamin F. L. Li, Peter F. Swann, and Dinshaw J. Patel. "Pyrimidine · pyrimidine base-pair mismatches in DNA." Journal of Molecular Biology 202, no. 1 (July 1988): 139–55. http://dx.doi.org/10.1016/0022-2836(88)90526-8.

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Inde, Takeshi, Yoshiaki Masaki, Atsuya Maruyama, Yu Ito, Naoaki Makio, Yuya Miyatake, Takahito Tomori, Mitsuo Sekine, and Kohji Seio. "Synthesis of oligonucleotides containing 2-N-heteroarylguanine residues and their effect on duplex/triplex stability." Organic & Biomolecular Chemistry 15, no. 39 (2017): 8371–83. http://dx.doi.org/10.1039/c7ob01875d.

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Shekouhy, Mohsen, and Ali Khalafi-Nezhad. "Polyethylene glycol-bonded 1,8-diazabicyclo[5.4.0]undec-7-ene (PEG–DBU) as a surfactant-combined base catalyst for the application of nucleosides as reagents in multi-component syntheses of 8-substituted pyrido[2,3-d]pyrimidine-6-carbonitriles in water." Green Chemistry 17, no. 10 (2015): 4815–29. http://dx.doi.org/10.1039/c5gc01448d.

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Lu, Nan, Yuxiang Bu, and Huatian Wang. "Intensified effects of multi-Cu modification on the electronic properties of the modified base pairs containing hetero-ring-expanded pyrimidine bases." Physical Chemistry Chemical Physics 18, no. 4 (2016): 2913–23. http://dx.doi.org/10.1039/c5cp06133d.

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Yamamoto, Seigi, Soyoung Park, and Hiroshi Sugiyama. "Development of a visible nanothermometer with a highly emissive 2′-O-methylated guanosine analogue." RSC Advances 5, no. 126 (2015): 104601–5. http://dx.doi.org/10.1039/c5ra24756j.

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Henley, Robert Y., Ana G. Vazquez-Pagan, Michael Johnson, Anastassia Kanavarioti, and Meni Wanunu. "Osmium-Based Pyrimidine Contrast Tags for Enhanced Nanopore-Based DNA Base Discrimination." PLOS ONE 10, no. 12 (December 11, 2015): e0142155. http://dx.doi.org/10.1371/journal.pone.0142155.

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Dissertations / Theses on the topic "Base pyrimidique"

1

Mederic, Christine. "Amplification du dna ribosomal nucleolaire chez l'euclene carencee en vitamine b::(12) : role possible de cette vitamine dans la synthese terminale des acides nucleiques." Paris 7, 1988. http://www.theses.fr/1988PA077116.

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Bruno, João Batista Canevari. "Efeito dos diferentes níveis de nucleotídeos em frangos de corte alimentados com probióticos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10135/tde-29072009-132711/.

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O objetivo deste trabalho foi avaliar o efeito dos diferentes níveis de nucleotídeos sobre o desempenho de frangos de corte alimentados com probióticos. Para o trabalho, foi utilizado um delineamento inteiramente casualizado com cinco repetições dentro de cada tratamento. Foram utilizados 1050 frangos machos da linhagem Ross 308 totalizando trinta e cinco aves por boxe. As aves foram criadas até 42 dias de idade que receberam as rações experimentais a base de milho e farelo de soja contendo seis diferentes níveis de nucleotídeos (0; 100; 200; 300; 400 e 500 gramas por tonelada de ração). Os diferentes níveis de nucleotídeos foram utilizados na fase inicial (1 a 21 dias de idade) e crescimento (22 a 35 dias de idade). Durante a fase final (36 a 42 dias de idade) foi fornecido rações sem nucleotídeo para todos os tratamentos. Os resultados experimentais demonstraram que houve melhora linear no desempenho dos frangos de corte no período de 1 a 21 dias de idade, indicando que, quanto maior o nível de nucleotídeos na dieta de frangos de corte, maior foi o peso corporal das aves. A conversão alimentar também é melhorou linearmente no período de 1 a 21 dias de idade à medida que aumentou o nível de nucleotídeos na ração. O peso no período de 35 dias de idade, também teve um comportamento linear, semelhante ao período de 1 a 21 dias, indicando que, quanto maior o nível de nucleotídeos na dieta de frangos de corte, maior o desempenho das aves. Quanto aos níveis plasmáticos de ácido úrico, pôde-se observar efeito quadrático no período de 1 a 21 dias de idade, indicando o valor de 231,59 gramas de nucleotídeos por tonelada de ração, como o melhor, em níveis mínimos de ácido úrico, por outro lado, no período de 35 dias de idade, estima-se o nível de 208,99 g de nucleotídeos por tonelada de ração; como o melhor em níveis mínimos de ácido úrico no sangue. No período final (35 a 42 dias de idade) e período total (1 a 42 dias de idade) não foi possível o observar efeito dos contrastes testados em nenhum dos parâmetros avaliados.
The objective of this experiment was to evaluate the influence of different nucleotides levels in the rations of broilers containing probiotics on response of the birds and its influence on the performance. Birds were allocated in a randomized experimental design with five replications of each treatment. It was used 1,050 chicks of a day of age, males, distributed in 30 experimental boxes with 35 birds each. The chickens were reared from 1 to 42 days of age and the diets contained corn and soybean meal with one of six different nucleotídes levels (0; 100; 200; 300; 400 and 500 grams for ton of ration). The different nucleotides levels were used in the initial phase (1 to 21 days of age) and growth (22 to 35 days of age). During the final phase (36 to 42 days of age) it was supplied rations without nucleotides for all of the treatments. The experimental results demonstrated that there was improvement on broilers performance in the period from 1 to 21 days of age, demonstrating proportionality between nucleotides level in the diet of broilers and body weight of the birds. Feed conversion at 21 days of age was directly proportional to nucleotides level in the diet. Body weight at 35 days of age, also had a linear behavior, similar to the period from 1 to 21 days, indicating that, as higher the nucleotides level in the diet of broilers, higher the acting of the birds. Acid plasmatic uric levels, demonstrated quadratic effect at 21 days of age, indicating 231,59 grams of nucleotides for ton of ration, and at 35 days of age, it was considered the level of 208,99 g of nucleotides for ton of ration. In the final period (35 to 42 days of age) and total period (1 to 42 days of age) it was not demonstrated effect of the contrasts tested in none of the appraised parameters.

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Boëns, Benjamin. "Synthèse et évaluation biologique de moutardes à l'azote à motifs pyrimidiques, puriques et triazoliques." Limoges, 2012. https://aurore.unilim.fr/theses/nxfile/default/62bf6d8a-876a-4afd-b44b-b4edd3d4e2a6/blobholder:0/2012LIMO4054.pdf.

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Au travers de ce manuscrit, nous décrivons la synthèse de moutardes à l’azote à motifs pyrimidiques, puriques ou triazoliques. Dans un premier temps, nous étudions la synthèse d’une moutarde à l’azote dérivée de l’uracile. L’étude de l’étape d’amidation directe a permis de généraliser cette méthode à diverses amines. Une e��tude de modélisation moléculaire a mis en évidence l’importance des interactions non liantes dans cette réaction. Dans une seconde partie, nous décrivons la synthèse de moutarde à l’azote à partir de bases puriques. Cette stratégie a conduit à la formation de composés tricycliques, dérivés de la purine. Dans une troisième partie, nous nous sommes intéressés à l’élaboration d’une nouvelle famille de moutardes à l’azote à motifs triazoliques. Grâce à l’utilisation de la réaction de CuAAC, nous avons synthétisé huit molécules aux structures innovantes. Cette dernière stratégie ouvre la voie à la synthèse d’une nouvelle famille de moutardes à l’azote aux motifs variés. Enfin, nous étudions l’activité biologique de certains des composés synthétisés par test de viabilité cellulaire, puis par cytométrie en flux. Deux composés obtenus ont présenté des résultats encourageants vis-à-vis de quatre lignées cancéreuses
The synthesis of pyrimidine, purine and triazole nitrogen mustards is described. First, we studied the synthesis of uracil-based nitrogen mustards. The amidation step was particularly studied and this method was extended to several amines. A series of DFT calculations highlighted the significance of non-bounding interactions in this amidation step. Second, the synthesis of several purine-based nitrogen mustards is described. This synthetic pathway led to the formation of tricyclic compounds, derive from purine. In a third part, we were interested in the elaboration of a new family of triazole nitrogen mustards. Thanks to the use of CuAAC reaction, we managed to synthesize 8 new nitrogen mustards. This latter strategy paves the way to the synthesis of a new family of nitrogen mustards, with an important structural variability. Furthermore, we studied the biological activity of synthesized compounds by testing their cytotoxicity and, then, by flow cytometry. Two of them showed encouraging results towards four cancer cells lines

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Colacino, Evelina. "Synthèse et étude de nouveaux analogues de nucléosides pyrimidiques modifiés sur la base hétérocyclique." Montpellier 2, 2002. http://www.theses.fr/2002MON20074.

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Horton, Aaron Michael. "Novel Reactive Dyes Based on Pyrimidine and Quinoxaline Systems." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-04302009-143537/.

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6

Hui, Benjamin Wei Qiang. "Construction of template-assembled pyrimidine-based quartets and quadruplexes." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/48391.

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Pyrimidine-based quartets and quadruplexes are unstable and thus are rarely encountered in nature. Uracil (U) and thymine (T) quartets in the solution state have only been found as part of pre-existing G-quadruplex scaffolds and the corresponding quadruplexes have not been reported. Studies on such systems might shed light on their role in nucleic acid topology and stability. This thesis describes the assembly and structural characterization of these motifs in vitro as a result of grafting the respective nucleosides onto resorcinol-based cavitands. These rigid macrocycles serve as molecular templates on which these motifs are preorganized. Reduction of entropic loss improves thermodynamic stability and promotes self-assembly. A convergent synthetic strategy was employed for accessing these cavitand-nucleoside conjugates. Cavitands and nucleosides were prepared separately using established literature methods, and the final coupling step of the two components entailed a copper (I)-catalyzed azide-alkyne cycloaddition, or a "click" reaction. NMR spectroscopy was used extensively in signal assignment, structure elucidation and oligomeric state analysis. CD spectroscopy was employed in some cases to provide further confirmation of defined structure. Findings indicated the spontaneous self-assembly of a U-quartet in CDCl3 at both 25 ºC and –20 ºC. In the presence of a metal cation (Sr²⁺), symmetric homodimerization of two U-quartets occurs at 25 ºC. The corresponding U-quadruplex unit was identified in DMSO-d₆ at 25 ºC. The T-quartet was shown to be nonexistent at 25 ºC, but assembles at a low temperature of –40 ºC. iii No evidence for metal cation uptake was found at 25 ºC. Assembly of the T-quadruplex was confirmed in DMSO-d₆ at 25 ºC. In all of these systems, stacking of the nucleobase and triazole linker rings was indicated suggesting π-stacking interactions to be a significant contributor to overall stability.
Science, Faculty of
Chemistry, Department of
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7

Colombeau, Ludovic. "Utilisation de bases pyrimidiques pour l'élaboration d'analogues d'oligonucléosides ou de la chlorméthine." Limoges, 2006. http://aurore.unilim.fr/theses/nxfile/default/044fad26-9129-4936-8c5a-4d6510208731/blobholder:0/2006LIMO0050.pdf.

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Nous décrivons la synthèse d’analogues d’oligonucléosides et de la chlorméthine à partir de bases pyrimidiques. Dans une première partie, la synthèse des analogues de dinucléosides reliés par une chaîne carbonée insaturée entre les positions 3’, 3 et 5’ à partir de la thymidine portant des groupements allyles est décrite. Un analogue de trinucléoside présentant la même chaîne carbonée entre les positions 3’ et 3 a également été synthétisé. L’étape clé de ces synthèses utilise la réaction de métathèse des oléfines. Une étude de cette réaction par activation micro-onde a été réalisée. Dans une seconde partie, nous présentons la synthèse d’agents alkylants à partir de bases pyrimidiques, suivie de leur évaluation biologique. L’étape clé de ces synthèses est la fixation d’une ou deux chaînes chloroéthyle sur la base pyrimidique, dont une optimisation a été réalisée par activation micro-onde. Certains analogues ont été glycosylés afin d’augmenter leur index thérapeutique. Tous les produits synthétisés ont été caractérisés par différentes méthodes spectroscopiques. L’activité anticancéreuse de plusieurs agents alkylants synthétisés donne des résultats préliminaires très encourageants
The synthesis of oligonucleoside and chlormethine analogues from pyrimidic bases is described. The first part presents the synthesis of dinucleoside analogues linked by an unsatured hydrocarbon chain between positions 3’, 3 and 5’ from thymidine with an allyle group. One trinucleoside analogue containing the same hydrocarbon chain between the positions 3’ and 3 is also synthesized. The key step of these syntheses is the use of olefin metathesis reaction. We performed a study of microwave-activated cross metathesis. In the second part, we present the synthesis and the biological activity of alkylating agents from pyrimidic bases. The key step of these syntheses is the fixation of one or two chloroethyle chains on pyrimidic base. An optimization of this step is obtained by microwave activation. Some analogues have been glycosylated to increase their therapeutic index. All synthesized products have been characterized by spectroscopic analyses. The antitumoral activity of several synthesized alkylating agents gave very interesting preliminary results

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Berthod, Thomas. "Synthèse d'oligonucléotides comportant des lésions radio- et photo-induites des bases pyrimidiques." Université Joseph Fourier (Grenoble ; 1971-2015), 1996. http://www.theses.fr/1996GRE10224.

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De nombreuses modifications des bases de l'adn peuvent etre generees par divers facteurs comme les agents oxydants ou cancerigenes, les rayonnements afin d'evaluer les consequences biologiques et physico-chimiques de ces dommages, il est necessaire de posseder des modeles plus complexes de ceux-ci qui peuvent etre obtenus par leur incorporation dans des oligonucleotides par voie chimique. Ce travail est consacre a la preparation de fragments d'adn contenant des derives de la 2'-desoxyuridine. Le premier volet de ce travail a consiste a preparer un synthon phosphoramidite de la 5-formyl-2'-desoxyuridine et a l'incorporer dans des oligonucleotides de synthese. La suite de ce travail concerne la mise en evidence et la caracterisation d'une nouvelle lesion, resultant de l'oxydation de la thymidine: la 5-carboxy-2'-desoxyuridine. Par ailleurs, la preparation d'oligonucleotides comportant cette lesion a ete realisee. La troisieme partie de ce travail correspond a l'incorporation d'un troisieme defaut dans des oligonucleotides: la 5,6-dihydro-2'-desoxyuridine (dhdu). Une etude plus complete sur les produits de degradation de cette lesion, susceptibles de se former en milieu alcalin, a ete ensuite menee avec le monomere et avec un trinucleotide, d(gdhdut). Dans une derniere partie, la recherche de conditions analytiques de separation de produits d'oxydation de la thymidine par electrophorese capillaire est presentee

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Nompex, Philippe. "Ozonation des bases puriques et pyrimidiques en milieu aqueux : études cinétiques et mécanismes." Poitiers, 1995. http://www.theses.fr/1995POIT2276.

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Le but de cette etude etait d'ameliorer les connaissances concernant l'action de l'ozone sur les bases puriques et pyrimidiques. Des etudes cinetiques de l'ozonation de la purine, de la pyrimidine, et de leurs nucleobases correspondantes (adenine, guanine, cytosine, thymine et uracile) ont ete conduites dans differents types de reacteurs, en milieu aqueux tamponne et en presence d'ions hydrogenocarbonates comme pieges a radicaux. L'ordre global des reactions a ete determine, ainsi que les stoechiometries et les constantes de vitesse pour chaque compose. En outre, l'influence du ph et de la temperature a ete etudiee dans le cas de la reaction ozone-purine. Des experimentations en reacteur semi-batch ont permis de comparer la reactivite de certaines nucleobases, d'un nucleoside et d'un nucleotide dans ces conditions experimentales. La mineralisation de l'azote et du carbone organique a ete suivie en fonction du taux d'ozonation. Pour l'adenine et la thymine, certains sous-produits d'ozonation ont ete identifies

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Romieu, Anthony. "Synthèse d'oligonucléotides modifiés comportant des lésions radio-induites des bases puriques et pyrimidiques." Université Joseph Fourier (Grenoble), 1999. http://www.theses.fr/1999GRE10140.

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Divers facteurs comme des agents oxydants ou cancerigenes, les rayonnement ultraviolets et ionisants, peuvent engendrer des modifications des bases de l'adn. Afin d'evaluer les consequences biologiques et physico-chimiques de ces dommages, l'obtention de courts fragments d'adn (oligonucleotides), de sequence definie (20 a 50 bases de long) et comportant une ou plusieurs modifications en des sites bien precis est primordiale. La synthese oligonucleotidique est aujourd'hui la methode de choix pour preparer de tels composes modeles. Ce travail est consacre a la preparation de fragments d'adn synthetiques contenant des nucleosides modifies formes lors de la radiolyse ou de la photosensibilisation des acides nucleiques. La premiere partie de cette these concerne la preparation d'un synthon phosphoramidite de la 5-hydroxy-2-desoxycytidine et l'incorporation de ce dernier dans des oligonucleotides de synthese de 14 a 33 bases de long. La deuxieme partie (chapitres iii et iv) concerne la synthese et l'incorporation de lesions radio-induites originales : les cyclonucleosides. Les deux diastereoisomeres (5r)- et (5s)- des 5,8-cyclopurine-2-desoxyribonucleosides ont ete inseres separement dans differents oligonucleotides (3 a 22 bases de long) en utilisant la chimie phosphoramidite classique. L'incorporation de la (5s, 6s)-5,6-cyclo-5,6-dihydrothymidine a egalement ete effectuee. La structure particuliere de ce cyclonucleosides (perte du caractere aromatique de l'heterocycle azote) ainsi que sa faible reactivite (determinee au cours de nos experiences) nous ont contraint au developpement d'une strategie de synthese radicalement differente de celle utilisee pour les 5,8-cyclopurine-2-desoxyribonucleosides. La troisieme partie de ce travail est consacre a la preparation d'un synthon phosphoramidite pour la 4-hydroxy-8-oxo-7,8-dihydro-2-desoxyguanosine. Au cours de l'une des etapes de synthese de ce precurseur, nous avons pu facilement separer les deux diastereoisomeres (4r)- et (4s)- de ce nucleoside modifie. Ils ont ete incorpores separemment dans les fragments d'adn synthetiques; l'epimerisation de la position c-4 n'etant pas observee au cours de la synthese sur support solide et lors de l'etape de deprotection ammoniacale. La derniere partie de ce manuscrit concerne la preparation d'oligonucleotides (2 a 9 bases de long) contenant un nucleoside modifie precurseur du radical 5-(2-desoxyuridilyl)methyle : la 5-(phenylthiomethyl)-2-desoxyuridine. Ces substrats ont ete utilises dans des etudes mecanistiques ayant pour but de preciser la reactivite de cet intermediaire radicalaire. Pour chacun des dommages incorpores une attention toute particuliere a ete portee a l'integrite des oligonucleotides synthetises. L'utilisation de differentes methodes analytiques (spectrometrie de masse et analyses clhp et maldi-tof des digestions enzymatiques) a permis de demontrer la purete des produits obtenus.

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Books on the topic "Base pyrimidique"

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Nishikawa, Michihiro. Photofunctionalization of Molecular Switch Based on Pyrimidine Ring Rotation in Copper Complexes. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54625-2.

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Nishikawa, Michihiro. Photofunctionalization of Molecular Switch Based on Pyrimidine Ring Rotation in Copper Complexes. Springer, 2016.

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Photofunctionalization Of Molecular Switch Based On Pyrimidine Ring Rotation In Copper Complexes. Springer Verlag, Japan, 2014.

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Book chapters on the topic "Base pyrimidique"

1

Callahan, Michael P. "Pyrimidine Base." In Encyclopedia of Astrobiology, 1391–92. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-11274-4_1313.

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Callahan, Michael P. "Pyrimidine Base." In Encyclopedia of Astrobiology, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-27833-4_1313-2.

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Callahan, Michael P. "Pyrimidine Base." In Encyclopedia of Astrobiology, 2095–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-44185-5_1313.

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Mah, Robert. "Pyrimidine-Based Kinase Inhibitors in Cancer Chemotherapy." In Bioactive Heterocyclic Compound Classes, 255–73. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2013. http://dx.doi.org/10.1002/9783527664450.ch16.

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Jeffrey, George A., and Wolfram Saenger. "Base Pairing in the Purine and Pyrimidine Crystal Structures." In Hydrogen Bonding in Biological Structures, 247–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-85135-3_16.

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Miller, John, Michael Cooney, Karol Miaskiewicz, and Roman Osman. "Modeling Duplex DNA Oligonucleotides with Modified Pyrimidine Bases." In ACS Symposium Series, 312–28. Washington, DC: American Chemical Society, 1997. http://dx.doi.org/10.1021/bk-1998-0682.ch019.

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Moriwaki, Yuji, Tetsuya Yamamoto, Sumio Takahashi, Yumiko Nasako, Toshikazu Hada, and Kazuya Higashino. "Renal Clearances of Purine Bases and Oxypurinol During Glucose Infusion." In Purine and Pyrimidine Metabolism in Man VIII, 39–42. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2584-4_10.

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Marinello, Enrico, Maria C. Di Pietro, Roberto Leoncini, Giulia Liso, Roberto Guerranti, Giuliano Cinci, and Daniela Vannoni. "Determination of Methylated Purine Bases in Urine from Healthy Subjects." In Purine and Pyrimidine Metabolism in Man X, 389–92. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/0-306-46843-3_74.

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Shishkin, Oleg V., Leonid Gorb, and Jerzy Leszczynski. "Conformational Flexibility of Pyrimidine Ring in Nucleic Acid Bases." In Practical Aspects of Computational Chemistry, 399–413. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-2687-3_21.

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Marlewski, Maciej, Ryszard T. Smolenski, Julian Swierczynski, Boleslaw Rutkowski, John A. Duley, H. Anne Simmonds, and Mariusz M. Zydowo. "Accelerated Purine Base Salvage — A Possible Cause of Elevated Nucleotide Pool in the Erythrocytes of Patients with Uraemia." In Purine and Pyrimidine Metabolism in Man VIII, 19–22. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-2584-4_5.

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Conference papers on the topic "Base pyrimidique"

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Martynov, Igor L., Evgeniy V. Osipov, Yriy A. Kuzishchin, Gennadii E. Kotkovskii, Egor V. Verbitskiy, Anna A. Baranova, Gennady L. Rusinov, Valery N. Charushin, and Alexander A. Chistyakov. "Pyrimidine-based dyes embedded in porous silicon microcavities for detection of nitroaromatic compounds." In Counterterrorism, Crime Fighting, Forensics, and Surveillance Technologies III, edited by Henri Bouma, Robert J. Stokes, Yitzhak Yitzhaky, and Radhakrishna Prabhu. SPIE, 2019. http://dx.doi.org/10.1117/12.2534674.

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Ercan, Dalia, Ting Xie, Marzia Capelletti, Nathanael S. Gray, and Pasi A. Janne. "Abstract 4832: Novel EGFR mutations that cause drug resistance to irreversible pyrimidine but not quinazoline based EGFR inhibitors." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4832.

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Luo, Yunting, Mathew Martin, Robert Kendig, Roberta Pireddu, Hua Yang, Stephane Betzi, Wesley Books, et al. "Abstract 3252: Potent Aurora kinase inhibitors based on a pyrimidine scaffold: Synthesis, SAR and X-ray crystallography studies." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3252.

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Sasabe, Hisahiro, Ryutaro Komatsu, Kohei Nakao, Yuya Hayasaka, and Junji Kido. "A series of pyrimidine based blue to green thermally activated delayed fluorescent emitters realizing a high EQE of 25%." In SPIE Organic Photonics + Electronics, edited by Franky So, Chihaya Adachi, and Jang-Joo Kim. SPIE, 2016. http://dx.doi.org/10.1117/12.2235681.

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Hsu, Yung Chang, Hui-Yi Shiao, Yi-Yu Ke, John T. A. Hsu, Wen-Hsing Lin, Chun-Hwa Chen, and Hsing-Pang Hsieh. "Abstract 2530: Optimization of 5,6-fused pyrimidine-based kinase inhibitors by computer-aided drug design for the treatment of AML." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2530.

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Lee, Ho-Jin, Hye-Young Min, Phuong Chi Pham, Byungyeob Baek, Byungjin Kim, Yunha Kim, Jeeyeon Lee, and Ho-Young Lee. "Abstract 2950: Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2950.

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Desmoulin, Sita Kugel, Lei Wang, Larry Tait, Lisa Polin, Zhanjun Hou, Christina Cherian, Aleem Gangjee, and Larry H. Matherly. "Abstract 2528: Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by PCFT." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-2528.

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Reports on the topic "Base pyrimidique"

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Griffin, L. C., L. L. Kiessling, and P. B. Dervan. Recognition of All Four Base Pairs of Duplex DNA by Triple Helix Formation. Design of Pyrimidine Specific Bases. Fort Belvoir, VA: Defense Technical Information Center, June 1991. http://dx.doi.org/10.21236/ada237360.

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