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1

Nozima, Khabibullaeva, and Khaitbaev Alisher. "Synthesis Of Schiff Bases From Glucosamine On The Basis Of Apis Mellifera." American Journal of Applied Sciences 02, no. 09 (September 30, 2020): 263–72. http://dx.doi.org/10.37547/tajas/volume02issue09-37.

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2

Kajal, Anu, Suman Bala, Sunil Kamboj, Neha Sharma, and Vipin Saini. "Schiff Bases: A Versatile Pharmacophore." Journal of Catalysts 2013 (August 27, 2013): 1–14. http://dx.doi.org/10.1155/2013/893512.

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Schiff bases are condensation products of primary amines with carbonyl compounds gaining importance day by day in present scenario. Schiff bases are the compounds carrying imine or azomethine (–C=N–) functional group and are found to be a versatile pharmacophore for design and development of various bioactive lead compounds. Schiff bases exhibit useful biological activities such anti-inflammatory, analgesic, antimicrobial, anticonvulsant, antitubercular, anticancer, antioxidant, anthelmintic, antiglycation, and antidepressant activities. Schiff bases are also used as catalysts, pigments and dyes, intermediates in organic synthesis, polymer stabilizers, and corrosion inhibitors. The present review summarizes information on the diverse biological activities and also highlights the recently synthesized numerous Schiff bases as potential bioactive core.
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3

Abdelnabi, S., Chasib K. Bkhakh, and Mouayed Y. Kadhum. "Synthesis , spectroscopic characterization and biological study of some new Schiff bases based on 2-hydroxybenzadehyde." JOURNAL OF ADVANCES IN CHEMISTRY 13, no. 2 (July 11, 2017): 5995–6005. http://dx.doi.org/10.24297/jac.v13i12.6117.

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Four new Schiff bases were synthesized from condensation of aldehyde ( 2-hydroxy benzaldehyde ) with aromatic amines (4-introaniline ; 4,4-oxydianiline ; 4,4-diaminodipleny sulfone and sulfanilamide) . These Schiff bases were characterized by IR, NMR , GC. mass and element analysis. Moreover, the Schiff bases were screened for their antibacterial and antifungal activity against various microorganisms and compared with standard compounds. In general , the results were indicated that some Schiff bases had good antimicrobial activity.
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4

Golovanov, A. S., M. M. Murza, and M. G. Safarov. "Novel mesomorphic Schiff bases." Chemistry of Heterocyclic Compounds 33, no. 11 (November 1997): 1350–51. http://dx.doi.org/10.1007/bf02320340.

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5

İspir, E., and S. Serin. "New immobilized Schiff bases." Journal of Thermal Analysis and Calorimetry 94, no. 1 (August 12, 2008): 281–88. http://dx.doi.org/10.1007/s10973-007-8900-3.

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6

Iacopetta, Domenico, Jessica Ceramella, Alessia Catalano, Carmela Saturnino, Maria Grazia Bonomo, Carlo Franchini, and Maria Stefania Sinicropi. "Schiff Bases: Interesting Scaffolds with Promising Antitumoral Properties." Applied Sciences 11, no. 4 (February 20, 2021): 1877. http://dx.doi.org/10.3390/app11041877.

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Schiff bases, named after Hugo Schiff, are highly reactive organic compounds broadly used as pigments and dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers. Lots of Schiff bases are described in the literature for various biological activities, including antimalarial, antibacterial, antifungal, anti-inflammatory, and antiviral. Schiff bases are also known for their ability to form complexes with several metals. Very often, complexes of Schiff bases with metals and Schiff bases alone have demonstrated interesting antitumor activity. Given the innumerable vastness of data regarding antitumor activity of all these compounds, we focused our attention on mono- and bis-Schiff bases alone as antitumor agents. We will highlight the most significant examples of compounds belonging to this class reported in the literature.
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7

A, Kumar. "Synthesis of some new Schiff bases of Pharmaceutical Interest." Annals of Advances in Chemistry 1, no. 2 (2017): 053–56. http://dx.doi.org/10.29328/journal.aac.1001006.

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8

Singh, Anil K., Camille Sandorfy, and Janos H. Fendler. "Dodecylammonium-glutamate Schiff bases of retinal." Canadian Journal of Chemistry 68, no. 7 (July 1, 1990): 1258–62. http://dx.doi.org/10.1139/v90-194.

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Dodecylammonium glutamate (4) has been prepared from dodecylamine (2) and l-glutamic acid (3) in ethanol and in aqueous ethanol. The obtained crystalline glutamic acid salt of dodecylamine (4) has been characterized by absorption, FTIR, 1H NMR, 13C NMR, and mass spectroscopy. Reaction of all-trans retinal (5) with the α-amino group of 4 gave a Schiff base (6), which was protonated by the α-COOH group of the glutamyl residue. However, the protonated Schiff base underwent acid-catalyzed hydrolysis to 2 + 3 + 5. Some of 5 reacted with 2 to give the corresponding Schiff base. The proposed structures have been substantiated by insitu absorption, FTIR, and 1H NMR spectroscopy. Keywords: retinal Schiff base, retinal, rhodopsin model, dodecylammonium glutamate, Schiff-base protonation.
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9

Wagh, Shaila, and B. R. Patil. "Synthesis and Spectral Characterization of Some New Novel Schiff bases Derived from Hydroxy Propiophenone." Oriental Journal Of Chemistry 37, no. 3 (June 30, 2021): 759–62. http://dx.doi.org/10.13005/ojc/370335.

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New Schiff bases derived by the condensation of methyl, chloro, and bromo substituted 2' hydroxy propiophenones with aliphatic and aromatic amines have been synthesized. The Schiff bases are yellow solids with sharp melting points. Schiff bases The spectral characterization of these newly synthesized Schiff base ligands has been done.These Schiff bases were characterized by IR spectroscopy, Nuclear magnetic resonance spectroscopy, UV spectroscopy, and Mass spectroscopy. IR spectra confirmed the presence of the phenolic OH group and azomethine group.
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10

Maji, Biplab, and Herbert Mayr. "Nucleophilic Reactivities of Schiff Bases." Zeitschrift für Naturforschung B 68, no. 5-6 (June 1, 2013): 693–99. http://dx.doi.org/10.5560/znb.2013-3085.

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The nucleophile-specific parameters N and sN, as defined by the linear free energy relationship log k = sN(N+E) (J. Am. Chem. Soc. 2001, 123, 9500 - 9512), were determined for five imines 1a-e by studying the kinetics of their reactions with benzhydrylium ions in dichloromethane solution at 20 °C. These parameters allowed us to include representative Schiff bases into our comprehensive nucleophilicity scale and compare their reactivities with those of other N-nucleophiles
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11

Ritter, Eglof, Piotr Przybylski, Bogumil Brzezinski, and Franz Bartl. "Schiff Bases in Biological Systems." Current Organic Chemistry 13, no. 3 (February 1, 2009): 241–49. http://dx.doi.org/10.2174/138527209787314805.

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12

Vasapollo, Giuseppe, and Howard Alper. "Direct diacylation of schiff bases." Tetrahedron Letters 29, no. 40 (January 1988): 5113–16. http://dx.doi.org/10.1016/s0040-4039(00)80693-0.

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13

Fernández-G., J. M., A. Rodríguez-Romero, K. Panneerselvam, and M. Soriano-García. "Two 2,3-Naphthalenic Schiff Bases." Acta Crystallographica Section C Crystal Structure Communications 51, no. 8 (August 15, 1995): 1643–46. http://dx.doi.org/10.1107/s0108270195001417.

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14

Bentama, A., S. Hoarau, L. Pappalardo, M. L. Roumestant, and P. Viallefont. "Sulfenylation of chiral Schiff bases." Amino Acids 7, no. 1 (1994): 105–8. http://dx.doi.org/10.1007/bf00808452.

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15

Gangani, Bhavesh J., and Parsotam H. Parsania. "Conventional and Microwave Irradiated Syntheses of New Symmetric Double Schiff Bases of 1,1’-Bis(4-Amino Phenyl)Cyclohexane, their Spectral Characterization and Microbial Activity." International Letters of Chemistry, Physics and Astronomy 58 (September 2015): 33–39. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.58.33.

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Symmetric double Schiff bases of 1,1’- bis (4-amino phenyl) cyclohexane and substituted aromatic benzaldehydes were synthesized by thermal and microwave irradiated green chemistry techniques. The purity of Schiff bases was checked by TLC. The structure of Schiff bases were supported by UV, FTIR, 1HNMR and MS techniques. The antibacterial and antifungal activities of Schiff bases were checked against gram positive and gram negative microbes. Schiff bases showed moderate antibacterial activity but they showed good comparable antifungal activity against chosen microbes and standard drugs.
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16

TERENT'EV, A. B., L. V. YASHKINA, E. V. PASTUSHENKO, D. E. KRUGLOV, and G. I. SAFIULOVA. "ChemInform Abstract: Novel Radical Reaction of Schiff Bases. Arylation of Schiff Bases with Nitrosoacetanilines." ChemInform 24, no. 10 (August 20, 2010): no. http://dx.doi.org/10.1002/chin.199310134.

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17

Rastogi, Rahul Kumar, and Poonam Garg. "Preparation and Characterisation of Trivalent Metal Complexes With Schiff Bases." Indian Journal of Applied Research 4, no. 2 (October 2011): 14–15. http://dx.doi.org/10.15373/2249555x/feb2014/24.

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18

Almarhoon, Zainab M., Wedad A. Al-Onazi, Asma A. Alothman, Amal M. Al-Mohaimeed, and Eida S. Al-Farraj. "Synthesis, DNA Binding, and Molecular Docking Studies of Dimethylaminobenzaldehyde-Based Bioactive Schiff Bases." Journal of Chemistry 2019 (July 1, 2019): 1–14. http://dx.doi.org/10.1155/2019/8152721.

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A new series of p-dimethylaminobenzaldehyde derivatives were tested for therapeutic potential by exploring their properties through characterization. The derivatives were synthesized by 1 : 1 condensation reaction of p-dimethylaminobenzaldehyde and substituted amines. The synthesized compounds 1–8 were characterized by different characterization techniques including IR, mass, 1H NMR, and 13C NMR spectroscopy, elemental analysis, and mass spectrometry. Furthermore, binding of these Schiff bases to Ct-DNA was examined by absorption spectroscopy, fluorescence quenching, circular dichroic, viscosity measurement, molecular docking, and molecular dynamics simulation methods. Schiff bases were tested for antimicrobial activity against bacterial species Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus by the disc diffusion method. The pharmacological treatment of Schiff bases showed that 1–8 have promising potential against tested bacterial strains. The molecular docking study of the target compounds was also carried out against B-DNA dodecamer d(CGCGAATTCGCG)2, and it has been found that 1–8 can bind to Ct-DNA via an intercalative mode. DPPH free radical and hydrogen peroxide scavenging assays were employed to assess the antioxidant potential of synthesized Schiff bases.
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19

Hassan, Ashraf S., Ahmed A. Askar, Ahmed M. Naglah, Abdulrahman A. Almehizia, and Ahmed Ragab. "Discovery of New Schiff Bases Tethered Pyrazole Moiety: Design, Synthesis, Biological Evaluation, and Molecular Docking Study as Dual Targeting DHFR/DNA Gyrase Inhibitors with Immunomodulatory Activity." Molecules 25, no. 11 (June 2, 2020): 2593. http://dx.doi.org/10.3390/molecules25112593.

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A series of Bis-pyrazole Schiff bases (6a–d and 7a–d) and mono-pyrazole Schiff bases (8a–d and 9a–d) were designed and synthesized through the reaction of 5-aminopyrazoles 1a–d with aldehydes 2–5 using mild reaction condition with a good yield percentage. The chemical structure of newly formed Schiff bases tethered pyrazole core was confirmed based on spectral and experimental data. All the newly formed pyrazole Schiff bases were evaluated against eight pathogens (Gram-positive, Gram-negative, and fungi). The result exhibited that, most of them have good and broad activities. Among those, only six Schiff bases (6b, 7b, 7c, 8a, 8d, and 9b) displayed MIC values (0.97–62.5 µg/mL) compared to Tetracycline (15.62–62.5 µg/mL) and Amphotericin B (15.62–31.25 µg/mL), MBC values (1.94–87.5 µg/mL) and selectivity to tumor cell than normal cells. Immunomodulatory activities showed that the promising Schiff bases increase the immunomodulator effect of defense cell and the Schiff base 8a is the highest one by (Intra. killing activity = 136.5 ± 0.3%) having a pyrazole moiety as well as amide function (O=C-NH2) and piperidinyl core. Furthermore, the most potent one exhibited broad activity depending on both MIC and MBC values. Moreover, to study the mechanism of these pyrazole Schiff bases, two active Schiff bases 8a and 9b from six derivatives were introduced to study the enzyme assay as dihydrofolate reductase (DHFR) on E. coli organism and DNA gyrase with two different organisms, S. aureus and B. subtilis, to determine the inhibitory activities with lower values in the case of DNA gyrase (8a and 9b) or nearly as DHFR compound 9b, while pyrazole 8a showed excellent inhibitory against all enzyme assay. The molecular docking study against dihydrofolate reductase and DNA gyrase were performed to study the binding between active site in the pocket with the two Schiff bases (8a and 9b) that exhibited good binding affinity with different bond types as H-bonding, aren-aren, and arene-cation interaction as well as study the physicochemical and pharmacokinetic properties of the two active Schiff bases 8a and 9b.
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20

Ahmed, Dina S., Mohammed Kadhom, Angham G. Hadi, Muna Bufaroosha, Nadia Salih, Wedad H. Al-Dahhan, and Emad Yousif. "Tetra Schiff Bases as Polyvinyl Chloride Thermal Stabilizers." Chemistry 3, no. 1 (February 17, 2021): 288–95. http://dx.doi.org/10.3390/chemistry3010021.

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Tetra Schiff bases were used as thermal stabilizers to enhance the properties of polyvinyl chloride (PVC) when operated at high temperatures. The thermal stability of PVC films doped with Schiff bases was tested by the weight-loss method, Fourier transform infrared (FTIR) spectroscopy, thermal aging test, optical microscope, and atomic force microscope (AFM). Results showed that embedding these additives increased the stability time of the polymer, which decreased the degradation reaction tendency. Furthermore, the primary color of PVC was improved by adding the Schiff bases using oven-aging. In addition, these Schiff bases resulted in a significant reduction in PVC’s conjugated double bonds and, hence, the weight loss.
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21

Yaseen, Anaheed A., Emaad T. B. Al-Tikrity, Emad Yousif, Dina S. Ahmed, Benson M. Kariuki, and Gamal A. El-Hiti. "Effect of Ultraviolet Irradiation on Polystyrene Containing Cephalexin Schiff Bases." Polymers 13, no. 17 (September 2, 2021): 2982. http://dx.doi.org/10.3390/polym13172982.

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The scale of production of polystyrene has escalated in the recent past in order to meet growing demand. As a result, a large quantity of polystyrene waste continues to be generated along with associated health and environmental problems. One way to tackle such problems is to lengthen the lifetime of polystyrene, especially for outdoor applications. Our approach is the synthesis and application of new ultraviolet photostabilizers for polystyrene and this research is focused on four cephalexin Schiff bases. The reaction of cephalexin and 3-hydroxybenzaldehyde, 4-dimethylaminobenzaldehyde, 4-methoxybenzaldehyde, and 4-bromobanzaldehyde under acidic condition afforded the corresponding Schiff bases in high yields. The Schiff bases were characterized and their surfaces were examined. The Schiff bases were mixed with polystyrene to form homogenous blends and their effectiveness as photostabilizers was explored using different methods. The methods included monitoring the changes in the infrared spectra, weight loss, depression in molecular weight, and surface morphology on irradiation. In the presence of the Schiff bases, the formation of carbonyl group fragments, weight loss, and decrease in molecular weight of polystyrene were lower when compared with pure polystyrene. In addition, undesirable changes in the surface such as the appearance of dark spots, cracks, and roughness were minimal for irradiated polystyrene containing cephalexin Schiff bases. Mechanisms by which cephalexin Schiff bases stabilize polystyrene against photodegradation have also been suggested.
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22

Husain, Asif, Munendra M. Varshney, Versha Parcha, Aftab Ahmad, and Shah A. Khan. "Nalidixic Acid Schiff Bases: Synthesis and Biological Evaluation." Letters in Drug Design & Discovery 15, no. 1 (January 3, 2018): 103–11. http://dx.doi.org/10.2174/1570180814666170710160751.

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Background: The prevalence of morbidity and mortality due to infections from parasitic worms and protozoa is on rise especially in third world countries. The situation is further worsened by drug resistant microbial pathogens. Objectives: The antimicrobial and anthelmintic activities associated with substituted furfuraldehyde and 1,8-naphthyridine nucleus of nalidixic acid prompted us to synthesize some new quinolone Schiff bases with an aim to obtain potent antibacterial and anthelmintic agents with improved safety and efficacy. Methods: A new series of 1,8 naphthyridine based Schiff bases were designed and synthesized by the reaction of Nalidixic acid methyl ester 1 with hydrazine hydrate in anhydrous condition which yielded 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazide 2. The compound 2 was further treated with several furfural aldehydes to furnish the desired Schiff bases (3a-k). The in vitro antibacterial activity of Schiff bases was investigated against four Gram positive and four Gram negative bacterial strains. The newly prepared Schiff bases were also tested for their anthelmintic activity against Pheritima posthuma and Perionyx excavatus. Results: Chemical structures and identity of the prepared compounds were confirmed by their spectral data. Overall, Schiff bases (3a-k) showed good antimicrobial activity and interestingly five compounds exhibited more potent inhibitory effect than the standard drug Ampicillin against S. aureus, B. cereus, E. faecalis, S. epidermidis, E. coli, S. typhi and S. dysenteriae. Schiff bases also exhibited significant anthelmintic activity as indicated by their mean paralyses time (min) of 7.07-16.49, and 11.23- 20.46 min against Perionyx excavatus and Pheritima posthuma in comparison to the 8.23 and 12.58 min shown by standard drug- Albendazole. Conclusion: It could be proposed that substitution of aromatic ring at C-5 of furfuryl heterocyclic ring in the Schiff bases produce compounds with promising antibacterial and anthelmintic actions.
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23

Wang, Lei, Yaqing Feng, Jinqiang Xue, and Li Yukun. "Synthesis and characterization of novel porphyrin Schiff bases." Journal of the Serbian Chemical Society 73, no. 1 (2008): 1–6. http://dx.doi.org/10.2298/jsc0801001w.

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Novel porphyrin Schiff bases were synthesized by a simple Schiff base condensation in refluxing toluene between 5-(4-aminophenyl)-10,15,20-triphe?nylporphyrin (ATTP) 3 and styryl aldehydes 4-6 or p-halobenzaldehydes 7-9. The newly synthesized porphyrin Schiff bases were characterized on the basis of their chemical properties and spectral data. A good intramolecular energy transfer from the styryl unit to the porphyrin moiety was found.
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24

Laddha, Purushottam R., and Kailash R. Biyani. "Synthesis and Biological Evaluation of Novel Schiff Bases of Aryloxy Moiety." Journal of Drug Delivery and Therapeutics 9, no. 5-s (October 15, 2019): 44–49. http://dx.doi.org/10.22270/jddt.v9i5-s.3635.

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Schiff's bases are condensation products of primary amines with carbonyl compounds. Schiff bases (imines) possess wide variety of biological activities that include antibacterial and antifungal activity. In present work, Schiff bases from 3,5- Dimethoxyphenol (aryloxy moiety) as starting material synthesized. Esterification of 3,5- Dimethoxyphenol led to formation of (3,5-Dimethoxy-phenoxy)-acetic acid ethyl ester (1). (3,5-Dimethoxy-phenoxy)-acetic acid hydrazide (2) is derived from Compound (1) by hydrazination. Compound (2) was reacted with different aromatic aldehydes to yield novel imines or Schiff bases (3A-I). The newly synthesized compounds were characterized on the basis of spectral studies and evaluated for antibacterial and antifungal activities. All the synthesized compounds had shown antibacterial and antifungal activity. Schiff bases 3C, 3D, 3E and 3I had shown good antimicrobial activity among all newly synthesized compounds. Keywords: Schiff base, aryloxy moiety, imines
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25

Chaudhary, Nrendra Kumar. "Synthesis and medicinal use of Metal complexes of Schiff Bases." BIBECHANA 9 (December 10, 2012): 75–80. http://dx.doi.org/10.3126/bibechana.v9i0.7178.

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Different Schemes for the synthesis of Schiff bases have been discussed. Solvent free synthesis by microwave irradiation technique is observed to be rapid, more efficient and more economical and at the same time may play a pivotal role in the progress of Schiff base synthesis. Mechanism for the synthesis of Schiff bases at controlled pH range has been studied. Biological functions of metal complexes of Schiff bases have found to be increased potentiality in presence of transition metal ions. DOI: http://dx.doi.org/10.3126/bibechana.v9i0.7178 BIBECHANA 9 (2013) 75-80
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26

Chohan, Zahid H., Asifa Munawar, and Claudiu T. Supuran. "Transition Metal Ion Complexes of Schiff-bases. Synthesis, Characterization and Antibacterial Properties." Metal-Based Drugs 8, no. 3 (January 1, 2001): 137–43. http://dx.doi.org/10.1155/mbd.2001.137.

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Some novel transition metal [Co(II), Cu(II), Ni(II) and Zn(II)] complexes of substituted pyridine Schiff-bases have been prepared and characterized by physical, spectral and analytical data. The synthesized Schiff-bases act as deprotonated tridentate for the complexation reaction with Co(II), Ni(II) and Zn(II) ions. The new compounds, possessing the general formula [M(L)2] where [M=Co(II), Cu(II), Ni(II) and Zn(II) and HL=HL1, HL2, HL3 and HL4] show an octahedral geometry. In order to evaluate the effect of metal ions upon chelation, the Schiff bases and their complexes have been screened for antibacterial activity against the strains such as Escherichia coli,Staphylococcus aureus, and Pseudomonas aeruginosa. The complexed Schiff bases have shown to be more antibacterial against one more bacterial species as compared to uncomplexed Schiff-bases.
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27

Singh, Kiran, Yogender Kumar, Parvesh Puri, Chetan Sharma, and Kamal Rai Aneja. "Metal-Based Biologically Active Compounds: Synthesis, Spectral, and Antimicrobial Studies of Cobalt, Nickel, Copper, and Zinc Complexes of Triazole-Derived Schiff Bases." Bioinorganic Chemistry and Applications 2011 (2011): 1–10. http://dx.doi.org/10.1155/2011/901716.

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A series of cobalt, nickel, copper, and zinc complexes of bidentate Schiff bases derived from the condensation reaction of 4-amino-5-mercapto-3-methyl/ethyl-1,2,4-triazole with 2,4-dichlorobenzaldehyde were synthesized and tested as antimicrobial agents. The synthesized Schiff bases and their metal complexes were characterized with the aid of elemental analyses, magnetic moment measurements, spectroscopic and thermogravimetric techniques. The presence of coordinated water in metal complexes was supported by infrared and thermal gravimetric studies. A square planar geometry was suggested for Cu(II) and octahedral geometry proposed for Co(II), Ni(II), and Zn(II) complexes. The Schiff bases and their metal complexes have been screened for antibacterial (Pseudomonas aeruginosa, Bacillus subtilis) and antifungal activities (Aspergillus niger, A. flavus). The metal complexes exhibited significantly enhanced antibacterial and antifungal activity as compared to their simple Schiff bases.
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28

Colmenares, Leticia U., and Robert S. H. Liu. "1H NMR and19F NMR chemical shifts of fluorinated retinals, Schiff bases and protonated Schiff bases." Magnetic Resonance in Chemistry 30, no. 6 (June 1992): 490–96. http://dx.doi.org/10.1002/mrc.1260300606.

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29

Chohan, Zahid H., and Muhammad Hanif. "Antibacterial and antifungal metal based triazole Schiff bases." Journal of Enzyme Inhibition and Medicinal Chemistry 28, no. 5 (July 18, 2012): 944–53. http://dx.doi.org/10.3109/14756366.2012.696246.

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30

Mkrtchyan, GEKhachatryanNI, and VB Gavalyan. "ANTIBACTERIAL PROPERTIES OF NEW CHITOSAN-BASED SCHIFF BASES." International Journal of Advanced Research 6, no. 7 (July 31, 2018): 1187–92. http://dx.doi.org/10.21474/ijar01/7474.

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31

Dubey, Ragini, Rajasekhar Yerrasani, M. Karunakar, Angad Kumar Singh, Rupali Gupta, Vellaichamy Ganesan, and T. R. Rao. "Benzimidazole based mesogenic Schiff-bases: Synthesis and characterization." Journal of Molecular Liquids 240 (August 2017): 106–14. http://dx.doi.org/10.1016/j.molliq.2017.05.061.

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32

Blagus, Anita, Dominik Cinčić, Tomislav Friščić, Branko Kaitner, and Vladimir Stilinović. "Schiff bases derived from hydroxyaryl aldehydes: molecular and crystal structure, tautomerism, quinoid effect, coordination compounds." Macedonian Journal of Chemistry and Chemical Engineering 29, no. 2 (December 15, 2010): 117. http://dx.doi.org/10.20450/mjcce.2010.159.

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During the last 50 years a vast number of structural studies on Schiff bases derived from hydroxyaryl aldehydes and their coordination compounds have been undertaken. In this review we present a systematic and brief overview of the most important discoveries and achievements accomplished in this field. The occurrence of Schiff bases (and their complexes) derived from nine most commonly used hydroxyaryl aldehydes in the Cambridge Structural Database (CSD) has been investigated. Keto-enol tautomerism and intramolecular hydrogen bonding in salicylaldimines and naphthaldimines is discussed, with a comment of the most common errors in determining the correct tautomeric form. Also, the interrelationship of crystal packing and the substituents on the Schiff base is studied. Finally, we give a short overview of conformational differences between free Schiff bases and Schiff bases bonded to metal ions as well as some structural characteristics of Schiff base metal complexes.
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33

Gan, Kwang-Chun, Kooi-Mow Sim, Tuck-Meng Lim, and Kah-Cheng Teo. "Synthesis, Cytotoxic, Antibacterial and Free Radical Scavenging Activities of New 1,2,4-Triazole Schiff Bases." Letters in Organic Chemistry 17, no. 3 (February 19, 2020): 191–98. http://dx.doi.org/10.2174/1570178616666190724114741.

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Twelve new 1,2,4-triazole Schiff bases bearing a fluorinated indole ring were successfully synthesized. The 1,2,4-triazole Schiff bases were synthesized from the condensation reaction of 4-amino-5-mercapto-3-[(5-fluoro-2-methyl-1H-indol-3-yl)methyl]-1,2,4-triazole with a series of benzaldehyde derivatives in the presence of (+)-tartaric acid as the catalyst. The structures of Schiff bases were elucidated by FTIR, NMR and mass spectral data. All newly synthesized Schiff bases were screened for their cytotoxic, antibacterial and free radical scavenging activities. Schiff bases 6b, 6c, 6i and 6j with hydroxyl group at ortho or meta position of the phenyl ring demonstrated higher cytotoxic activity against COLO-205 cell lines with IC50 94.0-144.3 µmol/mL. Schiff base bearing 2-OH and 5-Cl groups showed moderate antibacterial activity against Bacillus cereus at MIC 151 µmol/mL. On the other hand, compounds 6b (IC50 150.4 µmol/mL), 6e (IC50 146.4 µmol/mL), 6f (IC50 120.9 µmol/mL) and 6g (IC50 146.2 µmol/mL) displayed a better free radical scavenging activity than the standard BHT.
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34

Gan, Kwang-Chun, Kooi-Mow Sim, Tuck-Meng Lim, and Kah-Cheng Teo. "Synthesis, Cytotoxic, Antibacterial and Free Radical Scavenging Activities of Schiff Bases Derived from 1,2,4-Triazole." Letters in Organic Chemistry 16, no. 12 (October 9, 2019): 996–1003. http://dx.doi.org/10.2174/1570178616666190315154512.

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: A series of new 1,2,4-triazole Schiff bases incorporating a chlorinated indole moiety were prepared from the condensation reaction of 4-amino-5-mercapto-3-[(5-chloro-2-methyl-1H-indol-3- yl)methyl]1,2,4-triazole with substituted benzaldehydes in the presence of (+)-tartaric acid as an acidic catalyst. The structures of Schiff bases were elucidated by FTIR, NMR and mass spectral data. The cytotoxic, antibacterial and free radical scavenging activities of Schiff bases were performed using MTT, 96-well microbroth dilution and DPPH assays, respectively. Schiff bases 3k and 3l with both electron donating groups at meta and para positions of the phenyl ring demonstrated higher cytotoxic activity against COLO-205 and A549 cell lines. On the other hand, Schiff base 3f comprising p-chlorophenyl substituent exhibited significant inhibition against Bacillus cereus and Staphylococcus aureus at MIC 3.91 μg/ml and 15.63 μg/ml, respectively. The results of the free radical scavenging activity revealed that Schiff bases with the presence of a Cl or OCH3 group in the para position of the phenyl ring act as a better antioxidant than BHT.
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35

Journal, Baghdad Science. "Synthesis of substituted (oxazepine, Diazepine, tetrazde) via Schiff Bases for 2- Aminobenzo Thaizole Derivatives." Baghdad Science Journal 10, no. 3 (September 1, 2013): 736–48. http://dx.doi.org/10.21123/bsj.10.3.736-748.

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This work includs synthesis of several Schiff bases by condensation of 6- methoxy – 2- amino benzothiazole with some aldehydes and ketones (2- hydroxyl benzaldehyde, 4- hydroxyl benzaldehyde, 4- N,N –dimethy amino acetophenone, benzophenone) to abtain schiff bases (1-5). These schiff bases were found to react with phthalate anhydride to give oxazepine derivatives (6-10) that were reacted with primary aromatic amines to give Diazepine derivatives (11-15). Besides, we prepared new tetrazole derivatives (16-20) from the reaction of the prepared Schiff bases with sodium azide in the prepared compounds that were characterized by physical properties, FT-IR and some of the 1H-NMR and 13C –NMR spectroscopy.
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36

Panda, Jnyanaranjan. "Synthesis and Biological Evaluation of Some Isatin-based Mannich Bases." International Journal of Pharmaceutical Sciences and Nanotechnology 5, no. 4 (February 28, 2013): 1841–46. http://dx.doi.org/10.37285/ijpsn.2012.5.4.3.

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In this study, a series of isatin-based Mannich bases were prepared and their biological activity was evaluated. Schiff bases of isatin were synthesized by condensation of the keto group of isatin with different aromatic primary amines. The N-Mannich bases of the above Schiff bases were synthesized by reaction of the acidic imino group of isatin with formaldehyde and secondary amine. The chemical structures of the title compounds have been confirmed and elucidated by means of their physical and spectral data respectively. The compounds were tested for their possible antibacterial, analgesic and anti-inflammatory activities by the standard methods. Among the tested compounds, the compound containing the chloro group showed significant biological activity. These pilot studies demonstrate the usefulness of isatin-based Mannich bases.
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37

Rastogi, Rahul K., and S. Ahmad S. Ahmad. "Preparation and Characterisation of Manganese and Vanadium Complexes of Schiff Bases." Indian Journal of Applied Research 4, no. 1 (October 1, 2011): 88–90. http://dx.doi.org/10.15373/2249555x/jan2014/26.

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38

Jamil, Waqas, Shagufta Perveen, Syed Shah, Muhammad Taha, Nor Ismail, Shahnaz Perveen, Nida Ambreen, Khalid Khan, and Muhammad Choudhary. "Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors." Molecules 19, no. 7 (June 25, 2014): 8788–802. http://dx.doi.org/10.3390/molecules19078788.

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39

Srimurugan, Sankareswaran, Paulsamy Suresh, Balaji Babu, and Hari Pati. "Chiral Macrocyclic Schiff Bases: An Overview." Mini-Reviews in Organic Chemistry 5, no. 3 (August 1, 2008): 228–42. http://dx.doi.org/10.2174/157019308785161657.

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40

Selvakumar, K., and S. Vancheesan. "Cyclopalladated binuclear complexes of schiff bases." Polyhedron 15, no. 22 (August 1996): 3979–86. http://dx.doi.org/10.1016/0277-5387(96)00139-8.

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41

Hansen, P., Z. Rozwadowski, and T. Dziembowska. "NMR Studies of Hydroxy Schiff Bases." Current Organic Chemistry 13, no. 2 (January 1, 2009): 194–215. http://dx.doi.org/10.2174/138527209787193738.

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42

Golbedaghi, Reza, and Rui Fausto. "Coordination aspects in Schiff bases cocrystals." Polyhedron 155 (November 2018): 1–12. http://dx.doi.org/10.1016/j.poly.2018.06.049.

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43

Blickenstaff, Robert T., Shailaga Reddy, Robert Witt, and Kenny B. Lipkowitz. "Potential radioprotective agents — IV. Schiff bases." Bioorganic & Medicinal Chemistry 2, no. 12 (December 1994): 1363–66. http://dx.doi.org/10.1016/s0968-0896(00)82087-8.

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44

Kozlov, N. G., and L. I. Basalaeva. "Reaction of antipyrine with Schiff bases." Russian Journal of General Chemistry 76, no. 2 (February 2006): 302–6. http://dx.doi.org/10.1134/s107036320602023x.

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45

Guerriero, P., U. Casellato, S. Tamburini, P. A. Vigato, and R. Graziani. "Lanthanide complexes with compartmental schiff bases." Inorganica Chimica Acta 129, no. 1 (May 1987): 127–38. http://dx.doi.org/10.1016/s0020-1693(00)85915-0.

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46

Grigoras, M., Geta David, and I. Negulescu. "Copolymerization of Schiff Bases with Tetracyanoethylene." Journal of Macromolecular Science: Part A - Chemistry 28, no. 7 (July 1991): 601–12. http://dx.doi.org/10.1080/00222339108052111.

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47

Khan, Khalid, Uzma Mughal, Nida Ambreen, Ambreen Khan, Shahnaz Perveen, and Muhammad Iqbal Choudhary. "Schiff Bases of Istain: Antiglycation Activity." Letters in Drug Design & Discovery 6, no. 5 (July 1, 2009): 358–62. http://dx.doi.org/10.2174/1570180810906050358.

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48

Santos, Juliana, Rebeca Lima, Thamiris Pereira, Antonio Carmo, Nadia Raposo, and Adilson Silva. "Antioxidant Activity of Thio-Schiff Bases." Letters in Drug Design & Discovery 10, no. 7 (June 1, 2013): 557–60. http://dx.doi.org/10.2174/1570180811310070002.

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49

GOLOVANOV, A. S., M. M. MURZA, and M. G. SAFAROV. "ChemInform Abstract: New Mesomorphous Schiff Bases." ChemInform 29, no. 20 (June 22, 2010): no. http://dx.doi.org/10.1002/chin.199820157.

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50

Ozek, A., S. Yüce, Ç. Albayrak, M. Odabasoglu, and O. Büyükgüngör. "Structures of some hydroxynaphthaldehyde Schiff bases." Acta Crystallographica Section A Foundations of Crystallography 61, a1 (August 23, 2005): c292. http://dx.doi.org/10.1107/s0108767305087556.

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